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Timothy J. Hagen, Ph.D. - Publications

Affiliations: 
1988 University of Wisconsin-Milwaukee, Milwaukee, WI 
 2010- Chemistry Northern Illinois University, DeKalb, IL, United States 
Area:
Medicinal Chemistry
Website:
https://www.niu.edu/chembio/about/directories/faculty/hagen.shtml
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47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Pierce PG, Hartnett BE, Laughlin TM, Blain JM, Mayclin SJ, Bolejack MJ, Myers JB, Higgins TW, Dranow DM, Sullivan A, Lorimer DD, Edwards TE, Hagen TJ, Horn JR, Myler PJ. Crystal structure and biophysical characterization of IspD from Burkholderia thailandensis and Mycobacterium paratuberculosis. Acta Crystallographica. Section F, Structural Biology Communications. 80: 43-51. PMID 38305785 DOI: 10.1107/S2053230X24000621  0.302
2023 DeBouver ND, Bolejack MJ, Esan TE, Krysan DJ, Hagen TJ, Abendroth J. Bacterial structural genomics target enabled by a recently discovered potent fungal acetyl-CoA synthetase inhibitor. Acta Crystallographica. Section F, Structural Biology Communications. 79: 137-143. PMID 37223974 DOI: 10.1107/S2053230X23003801  0.325
2023 Sharma I, Chen C, Daraji D, Horn JR, Hagen TJ. Novel Inhibitors of Rickettsia prowazekii Methionine Aminopeptidase from the Malaria Box. Bioorganic & Medicinal Chemistry Letters. 129281. PMID 37031729 DOI: 10.1016/j.bmcl.2023.129281  0.805
2021 Blain JM, Grote DL, Watkins SM, Goshu GM, Muller C, Gorman JL, Ranieri G, Walter RL, Hofstetter H, Horn JR, Hagen TJ. Structural and biophysical characterization of the Burkholderia pseudomallei IspF inhibitor L-tryptophan hydroxamate. Bioorganic & Medicinal Chemistry Letters. 48: 128273. PMID 34298132 DOI: 10.1016/j.bmcl.2021.128273  0.779
2019 Watkins SM, Ghose D, Blain JM, Grote DL, Luan CH, Clare M, Meganathan R, Horn JR, Hagen TJ. Antibacterial activity of 2-amino-4-hydroxypyrimidine-5-carboxylates and binding to Burkholderia pseudomallei 2-C-methyl-d-erythritol-2,4-cyclodiphosphate synthase. Bioorganic & Medicinal Chemistry Letters. 126660. PMID 31521478 DOI: 10.1016/J.Bmcl.2019.126660  0.729
2019 Gurney ME, Nugent RA, Mo X, Sindac JA, Hagen TJ, Fox D, O'Donnell JM, Zhang C, Xu Y, Zhang HT, Groppi VE, Bailie M, White RE, Romero DL, Vellekoop AS, et al. Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders. Journal of Medicinal Chemistry. PMID 31013090 DOI: 10.1021/Acs.Jmedchem.9B00193  0.392
2018 Helgren TR, Seven ES, Chen C, Edwards TE, Staker BL, Abendroth J, Myler PJ, Horn JR, Hagen TJ. The identification of inhibitory compounds of Rickettsia prowazekii methionine aminopeptidase for antibacterial applications. Bioorganic & Medicinal Chemistry Letters. PMID 29551481 DOI: 10.1016/J.Bmcl.2018.03.002  0.774
2017 Helgren TR, Hagen TJ. Demonstration of AutoDock as an Educational Tool for Drug Discovery. Journal of Chemical Education. 94: 345-349. PMID 28670004 DOI: 10.1021/Acs.Jchemed.6B00555  0.794
2016 Helgren TR, Chen C, Wangtrakuldee P, Edwards TE, Staker BL, Abendroth J, Sankaran B, Housley NA, Myler PJ, Audia JP, Horn JR, Hagen TJ. Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents. Bioorganic & Medicinal Chemistry. PMID 28089350 DOI: 10.1016/J.Bmc.2016.11.013  0.729
2015 Goshu GM, Ghose D, Bain JM, Pierce PG, Begley DW, Hewitt SN, Udell HS, Myler PJ, Meganathan R, Hagen TJ. Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents. Bioorganic & Medicinal Chemistry Letters. PMID 26584881 DOI: 10.1016/J.Bmcl.2015.10.096  0.776
2015 Helgren TR, Wangtrakuldee P, Staker BL, Hagen TJ. Advances in Bacterial Methionine Aminopeptidase Inhibition. Current Topics in Medicinal Chemistry. PMID 26268344 DOI: 10.2174/1568026615666150813145410  0.756
2015 Helgren TR, Sciotti RJ, Lee P, Duffy S, Avery VM, Igbinoba O, Akoto M, Hagen TJ. The synthesis, antimalarial activity and CoMFA analysis of novel aminoalkylated quercetin analogs. Bioorganic & Medicinal Chemistry Letters. 25: 327-32. PMID 25488841 DOI: 10.1016/J.Bmcl.2014.11.039  0.798
2014 Hagen TJ, Mo X, Burgin AB, Fox D, Zhang Z, Gurney ME. Discovery of triazines as selective PDE4B versus PDE4D inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 4031-4. PMID 24998378 DOI: 10.1016/J.Bmcl.2014.06.002  0.502
2013 Wangtrakuldee P, Byrd MS, Campos CG, Henderson MW, Zhang Z, Clare M, Masoudi A, Myler PJ, Horn JR, Cotter PA, Hagen TJ. Discovery of Inhibitors of Burkholderia pseudomallei Methionine Aminopeptidase with Antibacterial Activity. Acs Medicinal Chemistry Letters. 4. PMID 24376907 DOI: 10.1021/Ml400034M  0.791
2013 Zhang Z, Jakkaraju S, Blain J, Gogol K, Zhao L, Hartley RC, Karlsson CA, Staker BL, Edwards TE, Stewart LJ, Myler PJ, Clare M, Begley DW, Horn JR, Hagen TJ. Cytidine derivatives as IspF inhibitors of Burkolderia pseudomallei. Bioorganic & Medicinal Chemistry Letters. 23: 6860-3. PMID 24157367 DOI: 10.1016/J.Bmcl.2013.09.101  0.795
2013 Dalby A, Mo X, Stoa R, Wroblewski N, Zhang Z, Hagen TJ. A concise synthesis of biaryl PDE4D allosteric modulators Tetrahedron Letters. 54: 2737-2739. DOI: 10.1016/J.Tetlet.2013.03.063  0.627
2010 Burgin AB, Magnusson OT, Singh J, Witte P, Staker BL, Bjornsson JM, Thorsteinsdottir M, Hrafnsdottir S, Hagen T, Kiselyov AS, Stewart LJ, Gurney ME. Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nature Biotechnology. 28: 63-70. PMID 20037581 DOI: 10.1038/Nbt.1598  0.395
2010 COX ED, HAGEN TJ, MCKERNAN RM, COOK JM. ChemInform Abstract: Bz1 Receptor Subtype Specific Ligands. Synthesis and Biological Properties of βCCt, a Bz1 Receptor Subtype Specific Antagonist. Cheminform. 27: no-no. DOI: 10.1002/chin.199621165  0.368
2010 ALLEN MS, TAN Y, TRUDELL ML, NARAYANAN K, SCHINDLER LR, MARTIN MJ, SCHULTZ C, HAGEN TJ, KOEHLER KF, CODDING PW, SKOLNICK P, COOK JM. ChemInform Abstract: Synthetic and Computer-Assisted Analyses of the Pharmacophore for the Benzodiazepine Receptor Inverse Agonist Site. Cheminform. 22: no-no. DOI: 10.1002/chin.199108209  0.643
2010 Singh J, Hagen TJ. Chirality and Biological Activity Burger's Medicinal Chemistry and Drug Discovery. 127-166. DOI: 10.1002/0471266949.Bmc016.Pub2  0.32
2004 Hallinan EA, Hagen TJ, Bergmanis A, Moore WM, Jerome GM, Spangler DP, Stevens AM, Shieh HS, Manning PT, Pitzele BS. 5-Fluorinated L-lysine analogues as selective induced nitric oxide synthase inhibitors. Journal of Medicinal Chemistry. 47: 900-6. PMID 14761191 DOI: 10.1021/Jm030348F  0.309
2002 Wang LJ, Grapperhaus ML, Pitzele BS, Hagen TJ, Fok KF, Scholten JA, Spangler DP, Toth MV, Jerome GM, Moore WM, Manning PT, Sikorski JA. Syntheses of new conformationally constrained S‐[2‐[(1‐iminoethyl)amino] ethyl]homocysteine derivatives as potential nitric oxide synthase inhibitors Heteroatom Chemistry. 13: 77-83. DOI: 10.1002/Hc.1109  0.309
2001 Hallinan EA, Hagen TJ, Tsymbalov S, Stapelfeld A, Savage MA. 2,4-Disubstituted oxazoles and thiazoles as latent pharmacophores for diacylhydrazine of SC-51089, a potent PGE2 antagonist. Bioorganic & Medicinal Chemistry. 9: 1-6. PMID 11197330 DOI: 10.1016/S0968-0896(00)00229-7  0.336
1998 Hagen TJ, Bergmanis AA, Kramer SW, Fok KF, Schmelzer AE, Pitzele BS, Swenton L, Jerome GM, Kornmeier CM, Moore WM, Branson LF, Connor JR, Manning PT, Currie MG, Hallinan EA. 2-Iminopyrrolidines as potent and selective inhibitors of human inducible nitric oxide synthase. Journal of Medicinal Chemistry. 41: 3675-83. PMID 9733492 DOI: 10.1021/Jm970840X  0.355
1998 Webber RK, Metz S, Moore WM, Connor JR, Currie MG, Fok KF, Hagen TJ, Hansen DW, Jerome GM, Manning PT, Pitzele BS, Toth MV, Trivedi M, Zupec ME, Tjoeng FS. Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms. Journal of Medicinal Chemistry. 41: 96-101. PMID 9438025 DOI: 10.1021/Jm9705059  0.411
1996 Hallinan EA, Hagen TJ, Tsymbalov S, Husa RK, Lee AC, Stapelfeld A, Savage MA. Aminoacetyl moiety as a potential surrogate for diacylhydrazine group of SC-51089, a potent PGE2 antagonist, and its analogs. Journal of Medicinal Chemistry. 39: 609-13. PMID 8558534 DOI: 10.1021/Jm950454K  0.365
1995 Codding PW, Roszak AW, Szkaradzinska MB, Cook JM, Hagen TJ, Allen MS. Structure – activity relationships in antagonist and inverse agonist ligands for the benzodiazepine receptor Canadian Journal of Chemistry. 73: 499-512. DOI: 10.1139/V95-065  0.514
1993 Hallinan EA, Hagen TJ, Husa RK, Tsymbalov S, Rao SN, vanHoeck JP, Rafferty MF, Stapelfeld A, Savage MA, Reichman M. N-substituted dibenzoxazepines as analgesic PGE2 antagonists. Journal of Medicinal Chemistry. 36: 3293-9. PMID 7901416  0.303
1992 Allen MS, LaLoggia AJ, Dorn LJ, Martin MJ, Costantino G, Hagen TJ, Koehler KF, Skolnick P, Cook JM. Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach. Journal of Medicinal Chemistry. 35: 4001-10. PMID 1331452 DOI: 10.1021/Jm00100A004  0.676
1991 Diaz-Arauzo H, Koehler KF, Hagen TJ, Cook JM. Synthetic and computer assisted analysis of the pharmacophore for agonists at benzodiazepine receptors. Life Sciences. 49: 207-16. PMID 1648158 DOI: 10.1016/0024-3205(91)90005-V  0.767
1990 Allen MS, Tan YC, Trudell ML, Narayanan K, Schindler LR, Martin MJ, Schultz C, Hagen TJ, Koehler KF, Codding PW. Synthetic and computer-assisted analyses of the pharmacophore for the benzodiazepine receptor inverse agonist site. Journal of Medicinal Chemistry. 33: 2343-57. PMID 2167977  0.699
1989 Martin JV, Cook JM, Hagen TJ, Mendelson WB. Inhibition of sleep and benzodiazepine receptor binding by a beta-carboline derivative. Pharmacology, Biochemistry, and Behavior. 34: 37-42. PMID 2560549 DOI: 10.1016/0091-3057(89)90349-3  0.417
1989 Takada K, Suzuki T, Hagen T, Cook JM, Katz JL. Behavioral effects of benzodiazepine antagonists in chlordiazepoxide tolerant and non-tolerant rats. Life Sciences. 44: 289-99. PMID 2492629 DOI: 10.1016/0024-3205(89)90187-2  0.429
1989 Hagen TJ, Narayanan K, Names J, Cook JM. DDQ oxidations in the indole area. Synthesis of 4-alkoxy-.beta.-carbolines including the natural products crenatine and 1-methoxycanthin-6-one Journal of Organic Chemistry. 54: 2170-2178. DOI: 10.1021/Jo00270A029  0.41
1989 CODDING PW, SZKARADZINSKA MB, ROSZAK AW, AHA LJ, HAGEN TJ, COOK JM. ChemInform Abstract: Structure-Activity Studies of β-Carbolines. Part 4. Crystal and Molecular Structures of tert.-Butyl β-Carboline-3-carboxylate and 2-(Methoxycarbonyl)canthin-6-one. Cheminform. 20. DOI: 10.1002/chin.198921311  0.352
1989 Hagen TJ, Narayanan K, Names J, Cook JM. DDQ oxidations in the indole area. Synthesis of 4-alkoxy-β-carbolines including the natural products crenatine and 1-methoxycanthin-6-one Journal of Organic Chemistry. 54: 2170-2178.  0.303
1988 Takada K, Hagen TJ, Cook JM, Goldberg SR, Katz JL. Discriminative stimulus effects of intravenous nicotine in squirrel monkeys. Pharmacology, Biochemistry, and Behavior. 30: 243-7. PMID 3174749 DOI: 10.1016/0091-3057(88)90452-2  0.394
1988 Trullas R, Ginter H, Jackson B, Skolnick P, Allen MS, Hagen TJ, Cook JM. 3-Ethoxy-beta-carboline: a high affinity benzodiazepine receptor ligand with partial inverse agonist properties. Life Sciences. 43: 1189-97. PMID 2845211 DOI: 10.1016/0024-3205(88)90208-1  0.579
1988 Allen MS, Hagen TJ, Trudell ML, Codding PW, Skolnick P, Cook JM. Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. Journal of Medicinal Chemistry. 31: 1854-61. PMID 2842507 DOI: 10.1021/Jm00117A029  0.696
1988 Codding PW, Szkaradzinska MB, Roszak AW, Aha LJ, Hagen TJ, Cook JM. Structure-activity studies of β-carbolines. 4. Crystal and molecular structures of t-butyl β-carboline-3-carboxylate and 2-(methoxycarbonyl)canthine-6-one Canadian Journal of Chemistry. 66: 2981-2988. DOI: 10.1139/V88-463  0.49
1988 Hagen TJ, Cook JM. Synthesis of 1-methoxy canthine-6-one Tetrahedron Letters. 29: 2421-2424. DOI: 10.1016/S0040-4039(00)87897-1  0.429
1988 HAGEN TJ, COOK JM. ChemInform Abstract: Synthesis of 1-Methoxycanthine-6-one (VIII). Cheminform. 19. DOI: 10.1002/chin.198843351  0.318
1987 Hagen TJ, Skolnick P, Cook JM. Synthesis of 6-substituted beta-carbolines that behave as benzodiazepine receptor antagonists or inverse agonists. Journal of Medicinal Chemistry. 30: 750-3. PMID 3031296 DOI: 10.1021/Jm00387A033  0.494
1987 Codding PW, Szkaradzinska MB, Cook JM, Hagen TJ. Mapping the β-carboline binding site on the benzodiazepine receptor oligomer Acta Crystallographica Section a Foundations of Crystallography. 43: C47-C47. DOI: 10.1107/S0108767387084241  0.359
1987 HAGEN TJ, GUZMAN F, SCHULTZ C, COOK JM, SKOLNICK P, SHANNON HE. ChemInform Abstract: Synthesis of 3,6-Disubstituted β-Carbolines which Possess Either Benzodiazepine Antagonist or Agonist Activity. Cheminform. 18. DOI: 10.1002/chin.198712218  0.387
1986 Hoffman WE, Albrecht RF, Miletich DJ, Hagen TJ, Cook JM. Cerebrovascular and cerebral metabolic effects of physostigmine, midazolam, and a benzodiazepine antagonist. Anesthesia and Analgesia. 65: 639-44. PMID 2939779 DOI: 10.1213/00000539-198606000-00013  0.424
1984 Guzman F, Cain M, Larscheid P, Hagen T, Cook JM, Schweri M, Skolnick P, Paul SM. Biomimetic approach to potential benzodiazepine receptor agonists and antagonists. Journal of Medicinal Chemistry. 27: 564-70. PMID 6325688 DOI: 10.1002/Chin.198443191  0.732
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