| Year |
Citation |
Score |
| 2020 |
Mukherjee M, Ratnayake I, Janga M, Fogarty E, Scheidt S, Grassmeyer J, deRiso J, Chandrasekar I, Ahrenkiel P, Kopan R, Surendran K. Notch signaling regulates Akap12 expression and primary cilia length during renal tubule morphogenesis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32474964 DOI: 10.1096/Fj.201902358Rr |
0.388 |
|
| 2020 |
Kuang Y, Golan O, Preusse K, Cain B, Christensen CJ, Salomone J, Campbell I, Okwubido-Williams FV, Hass MR, Yuan Z, Eafergan N, Moberg KH, Kovall RA, Kopan R, Sprinzak D, et al. Enhancer architecture sensitizes cell-specific responses to gene dose via a bind and discard mechanism. Elife. 9. PMID 32297857 DOI: 10.7554/Elife.53659 |
0.392 |
|
| 2020 |
Seymour PA, Collin CA, Egeskov-Madsen AR, Jørgensen MC, Shimojo H, Imayoshi I, de Lichtenberg KH, Kopan R, Kageyama R, Serup P. Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors. Developmental Cell. PMID 32059775 DOI: 10.1016/j.devcel.2020.01.015 |
0.406 |
|
| 2018 |
Farber G, Hurtado R, Loh S, Monette S, Mtui J, Kopan R, Quaggin S, Meyer-Schwesinger C, Herzlinger D, Scott RP, Blobel CP. Glomerular endothelial cell maturation depends on ADAM10, a key regulator of Notch signaling. Angiogenesis. PMID 29397483 DOI: 10.1007/S10456-018-9599-4 |
0.378 |
|
| 2017 |
Combes AN, Wilson S, Phipson B, Binnie BB, Ju A, Lawlor KT, Cebrian C, Walton SL, Smyth IM, Moritz KM, Kopan R, Oshlack A, Little MH. Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number. Kidney International. PMID 29217079 DOI: 10.1016/j.kint.2017.09.015 |
0.325 |
|
| 2017 |
Lander JM, Supp DM, He H, Martin LJ, Chen X, Weirauch MT, Boyce ST, Kopan R. Analysis of chromatin accessibility in human epidermis identifies putative barrier dysfunction-sensing enhancers. Plos One. 12: e0184500. PMID 28953906 DOI: 10.1371/Journal.Pone.0184500 |
0.31 |
|
| 2017 |
Kovall RA, Gebelein B, Sprinzak D, Kopan R. The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force. Developmental Cell. 41: 228-241. PMID 28486129 DOI: 10.1016/j.devcel.2017.04.001 |
0.421 |
|
| 2016 |
Cunningham TJ, Tabacchi M, Eliane JP, Tuchayi SM, Manivasagam S, Mirzaalian H, Turkoz A, Kopan R, Schaffer A, Saavedra AP, Wallendorf M, Cornelius LA, Demehri S. Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy. The Journal of Clinical Investigation. PMID 27869649 DOI: 10.1172/Jci89820 |
0.558 |
|
| 2016 |
Thomas JJ, Abed M, Heuberger J, Novak R, Zohar Y, Beltran Lopez AP, Trausch-Azar JS, Ilagan MX, Benhamou D, Dittmar G, Kopan R, Birchmeier W, Schwartz AL, Orian A. RNF4-Dependent Oncogene Activation by Protein Stabilization. Cell Reports. 16: 3388-400. PMID 27653698 DOI: 10.1016/j.celrep.2016.08.024 |
0.372 |
|
| 2016 |
Hayashi Y, Nishimune H, Hozumi K, Saga Y, Harada A, Yuzaki M, Iwatsubo T, Kopan R, Tomita T. A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons. Scientific Reports. 6: 23969. PMID 27040987 DOI: 10.1038/Srep23969 |
0.62 |
|
| 2016 |
Turkoz M, Townsend RR, Kopan R. The Notch intracellular domain has an RBPj-independent role during mouse hair follicular development. The Journal of Investigative Dermatology. PMID 26940862 DOI: 10.1016/J.Jid.2016.02.018 |
0.772 |
|
| 2016 |
Cunningham T, Tuchayi SM, Tabacchi M, Manivasagam S, Mirzaalian H, Turkoz A, Kopan R, Schaffer A, Wallendorf M, Cornelius L, Demehri S. 222 Topical 5-fluorouracil and calcipotriol combination: A potent immunotherapeutic for actinic keratosis Journal of Investigative Dermatology. 136. DOI: 10.1016/J.Jid.2016.02.251 |
0.514 |
|
| 2015 |
Chen S, Brunskill EW, Potter SS, Dexheimer PJ, Salomonis N, Aronow BJ, Hong CI, Zhang T, Kopan R. Intrinsic Age-Dependent Changes and Cell-Cell Contacts Regulate Nephron Progenitor Lifespan. Developmental Cell. 35: 49-62. PMID 26460946 DOI: 10.1016/J.Devcel.2015.09.009 |
0.3 |
|
| 2015 |
Demitrack ES, Gifford GB, Keeley TM, Carulli AJ, VanDussen KL, Thomas D, Giordano TJ, Liu Z, Kopan R, Samuelson LC. Notch signaling regulates gastric antral LGR5 stem cell function. The Embo Journal. PMID 26271103 DOI: 10.15252/Embj.201490583 |
0.392 |
|
| 2015 |
Hass MR, Liow HH, Chen X, Sharma A, Inoue YU, Inoue T, Reeb A, Martens A, Fulbright M, Raju S, Stevens M, Boyle S, Park JS, Weirauch MT, Brent MR, ... Kopan R, et al. SpDamID: Marking DNA Bound by Protein Complexes Identifies Notch-Dimer Responsive Enhancers. Molecular Cell. 59: 685-97. PMID 26257285 DOI: 10.1016/J.Molcel.2015.07.008 |
0.342 |
|
| 2015 |
Liu Z, Brunskill E, Varnum-Finney B, Zhang C, Zhang A, Jay PY, Bernstein I, Morimoto M, Kopan R. The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis. Development (Cambridge, England). 142: 2452-63. PMID 26062937 DOI: 10.1242/Dev.125492 |
0.447 |
|
| 2015 |
Liu Z, Brunskill E, Boyle S, Chen S, Turkoz M, Guo Y, Grant R, Kopan R. Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity. Development (Cambridge, England). 142: 1193-202. PMID 25725069 DOI: 10.1242/dev.119529 |
0.71 |
|
| 2014 |
Ilagan MX, Kopan R. Monitoring Notch activation in cultured mammalian cells: luciferase complementation imaging assays. Methods in Molecular Biology (Clifton, N.J.). 1187: 155-68. PMID 25053488 DOI: 10.1007/978-1-4939-1139-4_12 |
0.383 |
|
| 2014 |
Ilagan MX, Kopan R. Monitoring Notch activation in cultured mammalian cells: transcriptional reporter assays. Methods in Molecular Biology (Clifton, N.J.). 1187: 143-54. PMID 25053487 DOI: 10.1007/978-1-4939-1139-4_11 |
0.388 |
|
| 2014 |
Demehri S, Yockey LJ, Visness CM, Jaffee KF, Turkoz A, Wood RA, O'Connor GT, Kattan M, Gern JE, Gergen PJ, Holtzman M, Bloomberg G, Kopan R. Circulating TSLP associates with decreased wheezing in non-atopic preschool children: data from the URECA birth cohort. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. 44: 851-7. PMID 24397611 DOI: 10.1111/Cea.12270 |
0.562 |
|
| 2014 |
Boyle SC, Liu Z, Kopan R. Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development. Development (Cambridge, England). 141: 346-54. PMID 24353058 DOI: 10.1242/dev.100271 |
0.402 |
|
| 2014 |
Kopan R, Chen S, Liu Z. Alagille, Notch, and robustness: why duplicating systems does not ensure redundancy. Pediatric Nephrology (Berlin, Germany). 29: 651-7. PMID 24271660 DOI: 10.1007/s00467-013-2661-y |
0.403 |
|
| 2013 |
Chillakuri CR, Sheppard D, Ilagan MX, Holt LR, Abbott F, Liang S, Kopan R, Handford PA, Lea SM. Structural analysis uncovers lipid-binding properties of Notch ligands. Cell Reports. 5: 861-7. PMID 24239355 DOI: 10.1016/j.celrep.2013.10.029 |
0.433 |
|
| 2013 |
Zhao ZQ, Huo FQ, Jeffry J, Hampton L, Demehri S, Kim S, Liu XY, Barry DM, Wan L, Liu ZC, Li H, Turkoz A, Ma K, Cornelius LA, Kopan R, et al. Chronic itch development in sensory neurons requires BRAF signaling pathways. The Journal of Clinical Investigation. 123: 4769-80. PMID 24216512 DOI: 10.1172/Jci70528 |
0.617 |
|
| 2013 |
Satpathy AT, Briseño CG, Lee JS, Ng D, Manieri NA, Kc W, Wu X, Thomas SR, Lee WL, Turkoz M, McDonald KG, Meredith MM, Song C, Guidos CJ, Newberry RD, ... ... Kopan R, et al. Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nature Immunology. 14: 937-48. PMID 23913046 DOI: 10.1038/Ni.2679 |
0.673 |
|
| 2013 |
Liu Z, Chen S, Boyle S, Zhu Y, Zhang A, Piwnica-Worms DR, Ilagan MX, Kopan R. The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development. Developmental Cell. 25: 585-98. PMID 23806616 DOI: 10.1016/J.Devcel.2013.05.022 |
0.411 |
|
| 2013 |
Liu Z, Liu Z, Walters BJ, Owen T, Kopan R, Zuo J. In vivo visualization of Notch1 proteolysis reveals the heterogeneity of Notch1 signaling activity in the mouse cochlea. Plos One. 8: e64903. PMID 23741415 DOI: 10.1371/Journal.Pone.0064903 |
0.42 |
|
| 2013 |
Yockey LJ, Demehri S, Turkoz M, Turkoz A, Ahern PP, Jassim O, Manivasagam S, Kearney JF, Gordon JI, Kopan R. The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation. The Journal of Investigative Dermatology. 133: 2714-21. PMID 23698100 DOI: 10.1038/Jid.2013.228 |
0.769 |
|
| 2013 |
Groot AJ, Cobzaru C, Weber S, Saftig P, Blobel CP, Kopan R, Vooijs M, Franzke CW. Epidermal ADAM17 is dispensable for notch activation. The Journal of Investigative Dermatology. 133: 2286-8. PMID 23657465 DOI: 10.1038/Jid.2013.162 |
0.338 |
|
| 2013 |
Ilagan MX, Kopan R. Selective blockade of transport via SERCA inhibition: the answer for oncogenic forms of Notch? Cancer Cell. 23: 267-9. PMID 23518343 DOI: 10.1016/j.ccr.2013.02.020 |
0.331 |
|
| 2012 |
Morimoto M, Nishinakamura R, Saga Y, Kopan R. Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells. Development (Cambridge, England). 139: 4365-73. PMID 23132245 DOI: 10.1242/dev.083840 |
0.411 |
|
| 2012 |
Sato C, Turkoz M, Dearborn JT, Wozniak DF, Kopan R, Hass MR. Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged mice. Plos One. 7: e48180. PMID 23110206 DOI: 10.1371/Journal.Pone.0048180 |
0.762 |
|
| 2012 |
Demehri S, Turkoz A, Manivasagam S, Yockey LJ, Turkoz M, Kopan R. Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin. Cancer Cell. 22: 494-505. PMID 23079659 DOI: 10.1016/J.Ccr.2012.08.017 |
0.761 |
|
| 2012 |
Barak H, Huh SH, Chen S, Jeanpierre C, Martinovic J, Parisot M, Bole-Feysot C, Nitschké P, Salomon R, Antignac C, Ornitz DM, Kopan R. FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. Developmental Cell. 22: 1191-207. PMID 22698282 DOI: 10.1016/J.Devcel.2012.04.018 |
0.362 |
|
| 2012 |
Zheng J, Watanabe H, Wines-Samuelson M, Zhao H, Gridley T, Kopan R, Shen J. Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins. The Journal of Biological Chemistry. 287: 20356-68. PMID 22505716 DOI: 10.1074/Jbc.M112.349738 |
0.362 |
|
| 2012 |
Tu X, Chen J, Lim J, Karner CM, Lee SY, Heisig J, Wiese C, Surendran K, Kopan R, Gessler M, Long F. Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1. Plos Genetics. 8: e1002577. PMID 22457635 DOI: 10.1371/Journal.Pgen.1002577 |
0.362 |
|
| 2012 |
Mascia F, Denning M, Kopan R, Yuspa SH. The black box illuminated: signals and signaling. The Journal of Investigative Dermatology. 132: 811-9. PMID 22170487 DOI: 10.1038/Jid.2011.406 |
0.418 |
|
| 2012 |
Lee JS, Cella M, McDonald KG, Garlanda C, Kennedy GD, Nukaya M, Mantovani A, Kopan R, Bradfield CA, Newberry RD, Colonna M. AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Nature Immunology. 13: 144-51. PMID 22101730 DOI: 10.1038/Ni.2187 |
0.362 |
|
| 2012 |
Zheng J, Watanabe H, Wines-Samuelson M, Zhao H, Gridley T, Kopan R, Shen J. Reply to Gaiano et al.: Expression of notch proteins in pyramidal neurons in vivo Journal of Biological Chemistry. 287: 24596. DOI: 10.1074/Jbc.L112.380915 |
0.305 |
|
| 2011 |
Boyle SC, Kim M, Valerius MT, McMahon AP, Kopan R. Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells. Development (Cambridge, England). 138: 4245-54. PMID 21852398 DOI: 10.1242/Dev.070433 |
0.407 |
|
| 2011 |
Ilagan MX, Lim S, Fulbright M, Piwnica-Worms D, Kopan R. Real-time imaging of notch activation with a luciferase complementation-based reporter. Science Signaling. 4: rs7. PMID 21775282 DOI: 10.1126/Scisignal.2001656 |
0.465 |
|
| 2011 |
Surendran K, Kopan R. Chromatin-based mechanisms of renal epithelial differentiation. Journal of the American Society of Nephrology : Jasn. 22: 1208-12. PMID 21700830 DOI: 10.1681/ASN.2010101018 |
0.302 |
|
| 2011 |
Vooijs M, Liu Z, Kopan R. Notch: architect, landscaper, and guardian of the intestine. Gastroenterology. 141: 448-59. PMID 21689653 DOI: 10.1053/j.gastro.2011.06.003 |
0.348 |
|
| 2011 |
Liu Z, Turkoz A, Jackson EN, Corbo JC, Engelbach JA, Garbow JR, Piwnica-Worms DR, Kopan R. Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. The Journal of Clinical Investigation. 121: 800-8. PMID 21266774 DOI: 10.1172/Jci43114 |
0.375 |
|
| 2011 |
Pellegrinet L, Rodilla V, Liu Z, Chen S, Koch U, Espinosa L, Kaestner KH, Kopan R, Lewis J, Radtke F. Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology. 140: 1230-1240.e1-7. PMID 21238454 DOI: 10.1053/J.Gastro.2011.01.005 |
0.45 |
|
| 2011 |
Bloomberg G, Demehri S, Visness C, O'Connor G, Kattan M, Wood R, Gern J, Kopan R. Plasma Thymic Stromal Lymphopoietin Concentration is related to Allergen Sensitization in Young Children Journal of Allergy and Clinical Immunology. 127: AB126-AB126. DOI: 10.1016/J.Jaci.2010.12.502 |
0.512 |
|
| 2010 |
Arnett KL, Hass M, McArthur DG, Ilagan MX, Aster JC, Kopan R, Blacklow SC. Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nature Structural & Molecular Biology. 17: 1312-7. PMID 20972443 DOI: 10.1038/Nsmb.1938 |
0.39 |
|
| 2010 |
Costantini F, Kopan R. Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development. Developmental Cell. 18: 698-712. PMID 20493806 DOI: 10.1016/J.Devcel.2010.04.008 |
0.315 |
|
| 2010 |
Tong Y, Yamaguchi H, Giaime E, Boyle S, Kopan R, Kelleher RJ, Shen J. Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 9879-84. PMID 20457918 DOI: 10.1073/Pnas.1004676107 |
0.341 |
|
| 2010 |
Surendran K, Selassie M, Liapis H, Krigman H, Kopan R. Reduced Notch signaling leads to renal cysts and papillary microadenomas. Journal of the American Society of Nephrology : Jasn. 21: 819-32. PMID 20378824 DOI: 10.1681/ASN.2009090925 |
0.419 |
|
| 2010 |
Dumortier A, Durham AD, Di Piazza M, Vauclair S, Koch U, Ferrand G, Ferrero I, Demehri S, Song LL, Farr AG, Leonard WJ, Kopan R, Miele L, Hohl D, Finke D, et al. Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. Plos One. 5: e9258. PMID 20174635 DOI: 10.1371/Journal.Pone.0009258 |
0.661 |
|
| 2010 |
Zhao G, Liu Z, Ilagan MX, Kopan R. Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 1648-56. PMID 20130175 DOI: 10.1523/JNEUROSCI.3826-09.2010 |
0.394 |
|
| 2010 |
Morimoto M, Liu Z, Cheng HT, Winters N, Bader D, Kopan R. Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate. Journal of Cell Science. 123: 213-24. PMID 20048339 DOI: 10.1242/Dev.048249 |
0.631 |
|
| 2010 |
Johnson SE, Ilagan MX, Kopan R, Barrick D. Thermodynamic analysis of the CSL x Notch interaction: distribution of binding energy of the Notch RAM region to the CSL beta-trefoil domain and the mode of competition with the viral transactivator EBNA2. The Journal of Biological Chemistry. 285: 6681-92. PMID 20028974 DOI: 10.1074/jbc.M109.019968 |
0.386 |
|
| 2010 |
Surendran K, Boyle S, Barak H, Kim M, Stomberski C, McCright B, Kopan R. The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage. Developmental Biology. 337: 386-95. PMID 19914235 DOI: 10.1016/j.ydbio.2009.11.017 |
0.368 |
|
| 2010 |
Morimoto M, Saga Y, Kopan R. P96. Notch signaling regulates epithelial Clara/cilia fate selection and mesenchymal arterial SMC determination during lung organogenesis Differentiation. 80. DOI: 10.1016/J.Diff.2010.09.102 |
0.445 |
|
| 2009 |
Riesenberg AN, Liu Z, Kopan R, Brown NL. Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12865-77. PMID 19828801 DOI: 10.1523/JNEUROSCI.3382-09.2009 |
0.311 |
|
| 2009 |
van Tetering G, van Diest P, Verlaan I, van der Wall E, Kopan R, Vooijs M. Metalloprotease ADAM10 is required for Notch1 site 2 cleavage. The Journal of Biological Chemistry. 284: 31018-27. PMID 19726682 DOI: 10.1074/jbc.M109.006775 |
0.427 |
|
| 2009 |
Cras-Méneur C, Li L, Kopan R, Permutt MA. Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window. Genes & Development. 23: 2088-101. PMID 19723764 DOI: 10.1101/gad.1800209 |
0.45 |
|
| 2009 |
Bazzi H, Demehri S, Potter CS, Barber AG, Awgulewitsch A, Kopan R, Christiano AM. Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation. Differentiation; Research in Biological Diversity. 78: 292-300. PMID 19683850 DOI: 10.1016/J.Diff.2009.06.004 |
0.624 |
|
| 2009 |
Demehri S, Turkoz A, Kopan R. Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell. 16: 55-66. PMID 19573812 DOI: 10.1016/J.Ccr.2009.05.016 |
0.61 |
|
| 2009 |
Demehri S, Morimoto M, Holtzman MJ, Kopan R. Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. Plos Biology. 7: e1000067. PMID 19557146 DOI: 10.1371/Journal.Pbio.1000067 |
0.587 |
|
| 2009 |
Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell. 137: 216-33. PMID 19379690 DOI: 10.1016/j.cell.2009.03.045 |
0.432 |
|
| 2009 |
Demehri S, Kopan R. Notch signaling in bulge stem cells is not required for selection of hair follicle fate. Development (Cambridge, England). 136: 891-6. PMID 19211676 DOI: 10.1242/Dev.030700 |
0.658 |
|
| 2009 |
Cai J, Lee J, Kopan R, Ma L. Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation. Developmental Biology. 326: 420-30. PMID 19103190 DOI: 10.1016/J.Ydbio.2008.11.021 |
0.794 |
|
| 2009 |
Hass MR, Sato C, Kopan R, Zhao G. Presenilin: RIP and beyond. Seminars in Cell & Developmental Biology. 20: 201-10. PMID 19073272 DOI: 10.1016/J.Semcdb.2008.11.014 |
0.601 |
|
| 2008 |
Ong CT, Sedy JR, Murphy KM, Kopan R. Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition. Plos One. 3: e2823. PMID 18665263 DOI: 10.1371/Journal.Pone.0002823 |
0.606 |
|
| 2008 |
Demehri S, Liu Z, Lee J, Lin MH, Crosby SD, Roberts CJ, Grigsby PW, Miner JH, Farr AG, Kopan R. Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. Plos Biology. 6: e123. PMID 18507503 DOI: 10.1371/Journal.Pbio.0060123 |
0.803 |
|
| 2008 |
Hilton MJ, Tu X, Wu X, Bai S, Zhao H, Kobayashi T, Kronenberg HM, Teitelbaum SL, Ross FP, Kopan R, Long F. Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nature Medicine. 14: 306-14. PMID 18297083 DOI: 10.1038/Nm1716 |
0.371 |
|
| 2008 |
Bai S, Kopan R, Zou W, Hilton MJ, Ong CT, Long F, Ross FP, Teitelbaum SL. NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. The Journal of Biological Chemistry. 283: 6509-18. PMID 18156632 DOI: 10.1074/Jbc.M707000200 |
0.64 |
|
| 2008 |
Lee J, Wu W, Kopan R. Murine vibrissae cultured in serum-free medium reinitiate anagen. The Journal of Investigative Dermatology. 128: 482-5. PMID 17687387 DOI: 10.1038/Sj.Jid.5701024 |
0.739 |
|
| 2008 |
Demehri S, Liu Z, Lee J, Lin MH, Crosby SD, Roberts CJ, Grigsby PW, Miner JH, Farr AG, Kopan R. Correction: Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity (PLoS Biology (2008) 6,5 (e123) DOI: 10.1371/journal.pbio.0060123) Plos Biology. 6: 1599. DOI: 10.1371/journal.pbio.0060169 |
0.767 |
|
| 2008 |
Demehri S, Liu Z, Lee J, Lin M, Crosby S, Roberts C, Grigsby P, Miner J, Farr A, Kopan R. O4-03-06: Notch or gamma-secretase-deficient skin creates an environment inducing a lethal systemic B-lymphoproliferative disorder by overproducing TSLP, a sentinel for epidermal integrity Alzheimer's & Dementia. 4: T190-T190. DOI: 10.1016/J.Jalz.2008.05.523 |
0.769 |
|
| 2007 |
Khandelwal A, Chandu D, Roe CM, Kopan R, Quatrano RS. Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved. Proceedings of the National Academy of Sciences of the United States of America. 104: 13337-42. PMID 17684101 DOI: 10.1073/Pnas.0702038104 |
0.386 |
|
| 2007 |
Lee J, Basak JM, Demehri S, Kopan R. Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes. Development (Cambridge, England). 134: 2795-806. PMID 17611229 DOI: 10.1242/Dev.02868 |
0.803 |
|
| 2007 |
Kopan R, Cheng HT, Surendran K. Molecular insights into segmentation along the proximal-distal axis of the nephron. Journal of the American Society of Nephrology : Jasn. 18: 2014-20. PMID 17568016 DOI: 10.1681/Asn.2007040453 |
0.564 |
|
| 2007 |
Ilagan MX, Kopan R. SnapShot: notch signaling pathway. Cell. 128: 1246. PMID 17382890 DOI: 10.1016/j.cell.2007.03.011 |
0.389 |
|
| 2007 |
Cheng HT, Kim M, Valerius MT, Surendran K, Schuster-Gossler K, Gossler A, McMahon AP, Kopan R. Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development (Cambridge, England). 134: 801-11. PMID 17229764 DOI: 10.1242/Dev.02773 |
0.671 |
|
| 2007 |
Vooijs M, Ong CT, Hadland B, Huppert S, Liu Z, Korving J, van den Born M, Stappenbeck T, Wu Y, Clevers H, Kopan R. Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development (Cambridge, England). 134: 535-44. PMID 17215306 DOI: 10.1242/Dev.02733 |
0.791 |
|
| 2007 |
Lubman OY, Ilagan MX, Kopan R, Barrick D. Quantitative dissection of the Notch:CSL interaction: insights into the Notch-mediated transcriptional switch. Journal of Molecular Biology. 365: 577-89. PMID 17070841 DOI: 10.1016/J.Jmb.2006.09.071 |
0.371 |
|
| 2007 |
Hayashi Y, Tomita T, Kopan R, Iwatsubo T. The role of Notch signaling in synaptogenesis Neuroscience Research. 58. DOI: 10.1016/J.Neures.2007.06.863 |
0.632 |
|
| 2006 |
Weinmaster G, Kopan R. A garden of Notch-ly delights. Development (Cambridge, England). 133: 3277-82. PMID 16908627 DOI: 10.1242/Dev.02515 |
0.397 |
|
| 2006 |
Keller PC, Tomita T, Hayashi I, Chandu D, Weber JD, Cistola DP, Kopan R. A faster migrating variant masquerades as NICD when performing in vitro gamma-secretase assays with bacterially expressed Notch substrates. Biochemistry. 45: 5351-8. PMID 16618124 DOI: 10.1021/Bi052228A |
0.742 |
|
| 2006 |
Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R, Kodama T, Hamakubo T, Iwatsubo T, Iwastubo T, Tomita T, Sato C. Three-dimensional structure of the gamma-secretase complex. Biochemical and Biophysical Research Communications. 343: 525-34. PMID 16546128 DOI: 10.1016/j.bbrc.2006.02.158 |
0.594 |
|
| 2006 |
Barrick D, Kopan R. The Notch transcription activation complex makes its move. Cell. 124: 883-5. PMID 16530033 DOI: 10.1016/j.cell.2006.02.028 |
0.341 |
|
| 2006 |
Yang X, Tomita T, Wines-Samuelson M, Beglopoulos V, Tansey MG, Kopan R, Shen J. Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord. Developmental Neuroscience. 28: 102-17. PMID 16508308 DOI: 10.1159/000090757 |
0.481 |
|
| 2006 |
Ong CT, Cheng HT, Chang LW, Ohtsuka T, Kageyama R, Stormo GD, Kopan R. Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. The Journal of Biological Chemistry. 281: 5106-19. PMID 16365048 DOI: 10.1074/Jbc.M506108200 |
0.729 |
|
| 2006 |
Chandu D, Huppert SS, Kopan R. Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by gamma-secretase. Journal of Neurochemistry. 96: 228-35. PMID 16300632 DOI: 10.1111/J.1471-4159.2005.03547.X |
0.359 |
|
| 2006 |
Chandu D, Huppert SS, Kopan R. CORRIGENDUM: Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by γ-secretase Journal of Neurochemistry. 98: 2043-2043. DOI: 10.1111/J.1471-4159.2006.04091.X |
0.338 |
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| 2006 |
Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R, Kodama T, Hamakubo T, Iwatsubo T, Tomita T, Sato C. Corrigendum to "Three-dimensional structure of the γ-secretase complex" [Biochem. Biophys. Res. Commun. 343 (2006) 525-534] (DOI:10.1016/j.bbrc.2006.02.158) Biochemical and Biophysical Research Communications. 345: 543. DOI: 10.1016/j.bbrc.2006.04.025 |
0.525 |
|
| 2005 |
Cheng HT, Kopan R. The role of Notch signaling in specification of podocyte and proximal tubules within the developing mouse kidney. Kidney International. 68: 1951-2. PMID 16221173 DOI: 10.1111/J.1523-1755.2005.00627.X |
0.645 |
|
| 2005 |
Pan Y, Liu Z, Shen J, Kopan R. Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis. Developmental Biology. 286: 472-82. PMID 16169548 DOI: 10.1016/J.Ydbio.2005.08.037 |
0.665 |
|
| 2005 |
Kiernan AE, Cordes R, Kopan R, Gossler A, Gridley T. The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear. Development (Cambridge, England). 132: 4353-62. PMID 16141228 DOI: 10.1242/Dev.02002 |
0.422 |
|
| 2005 |
Huppert SS, Ilagan MX, De Strooper B, Kopan R. Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. Developmental Cell. 8: 677-88. PMID 15866159 DOI: 10.1016/J.Devcel.2005.02.019 |
0.428 |
|
| 2005 |
Lubman OY, Kopan R, Waksman G, Korolev S. The crystal structure of a partial mouse Notch-1 ankyrin domain: repeats 4 through 7 preserve an ankyrin fold. Protein Science : a Publication of the Protein Society. 14: 1274-81. PMID 15802643 DOI: 10.1110/Ps.041184105 |
0.374 |
|
| 2004 |
Pan Y, Lin MH, Tian X, Cheng HT, Gridley T, Shen J, Kopan R. gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Developmental Cell. 7: 731-43. PMID 15525534 DOI: 10.1016/J.Devcel.2004.09.014 |
0.763 |
|
| 2004 |
Vooijs M, Schroeter EH, Pan Y, Blandford M, Kopan R. Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization. The Journal of Biological Chemistry. 279: 50864-73. PMID 15448134 DOI: 10.1074/Jbc.M409430200 |
0.817 |
|
| 2004 |
Nichols AM, Pan Y, Herreman A, Hadland BK, De Strooper B, Kopan R, Huppert SS. Notch pathway is dispensable for adipocyte specification. Genesis (New York, N.Y. : 2000). 40: 40-4. PMID 15354292 DOI: 10.1002/Gene.20061 |
0.779 |
|
| 2004 |
Koo EH, Kopan R. Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. Nature Medicine. 10: S26-33. PMID 15272268 DOI: 10.1038/Nm1065 |
0.353 |
|
| 2004 |
Hadland BK, Huppert SS, Kanungo J, Xue Y, Jiang R, Gridley T, Conlon RA, Cheng AM, Kopan R, Longmore GD. A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. Blood. 104: 3097-105. PMID 15251982 DOI: 10.1182/Blood-2004-03-1224 |
0.717 |
|
| 2004 |
Kopan R, Ilagan MX. Gamma-secretase: proteasome of the membrane? Nature Reviews. Molecular Cell Biology. 5: 499-504. PMID 15173829 DOI: 10.1038/nrm1406 |
0.402 |
|
| 2004 |
Yang X, Klein R, Tian X, Cheng HT, Kopan R, Shen J. Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Developmental Biology. 269: 81-94. PMID 15081359 DOI: 10.1016/J.Ydbio.2004.01.014 |
0.644 |
|
| 2004 |
Lubman OY, Korolev SV, Kopan R. Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data. Molecular Cell. 13: 619-26. PMID 15023333 DOI: 10.1016/S1097-2765(04)00120-0 |
0.435 |
|
| 2003 |
Lin MH, Kopan R. Long-range, nonautonomous effects of activated Notch1 on tissue homeostasis in the nail. Developmental Biology. 263: 343-59. PMID 14597207 DOI: 10.1016/j.ydbio.2003.07.007 |
0.426 |
|
| 2003 |
Hu QD, Ang BT, Karsak M, Hu WP, Cui XY, Duka T, Takeda Y, Chia W, Sankar N, Ng YK, Ling EA, Maciag T, Small D, Trifonova R, Kopan R, et al. F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation. Cell. 115: 163-75. PMID 14567914 DOI: 10.1016/S0092-8674(03)00810-9 |
0.418 |
|
| 2003 |
Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Goate A, Wolfe MS, ... ... Kopan R, et al. A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 100: 13075-80. PMID 14566063 DOI: 10.1073/Pnas.1735338100 |
0.78 |
|
| 2003 |
Cheng HT, Miner JH, Lin M, Tansey MG, Roth K, Kopan R. Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney. Development (Cambridge, England). 130: 5031-42. PMID 12952904 DOI: 10.1242/Dev.00697 |
0.665 |
|
| 2003 |
Selkoe D, Kopan R. Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. Annual Review of Neuroscience. 26: 565-97. PMID 12730322 DOI: 10.1146/annurev.neuro.26.041002.131334 |
0.437 |
|
| 2002 |
Kopan R, Goate A. Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization. Neuron. 33: 321-4. PMID 11832221 DOI: 10.1016/S0896-6273(02)00585-8 |
0.45 |
|
| 2002 |
Kopan R, Lee J, Lin MH, Syder AJ, Kesterson J, Crutchfield N, Li CR, Wu W, Books J, Gordon JI. Genetic mosaic analysis indicates that the bulb region of coat hair follicles contains a resident population of several active multipotent epithelial lineage progenitors. Developmental Biology. 242: 44-57. PMID 11795939 DOI: 10.1006/Dbio.2001.0516 |
0.759 |
|
| 2001 |
Huppert S, Kopan R. Regulated intramembrane proteolysis takes another twist. Developmental Cell. 1: 590-2. PMID 11709178 DOI: 10.1016/S1534-5807(01)00081-8 |
0.369 |
|
| 2001 |
Saxena MT, Schroeter EH, Mumm JS, Kopan R. Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis. The Journal of Biological Chemistry. 276: 40268-73. PMID 11518718 DOI: 10.1074/Jbc.M107234200 |
0.81 |
|
| 2001 |
Tomita T, Watabiki T, Takikawa R, Morohashi Y, Takasugi N, Kopan R, De Strooper B, Iwatsubo T. The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins. The Journal of Biological Chemistry. 276: 33273-81. PMID 11432849 DOI: 10.1074/jbc.M011152200 |
0.613 |
|
| 2001 |
Hadland BK, Manley NR, Su D, Longmore GD, Moore CL, Wolfe MS, Schroeter EH, Kopan R. Gamma -secretase inhibitors repress thymocyte development. Proceedings of the National Academy of Sciences of the United States of America. 98: 7487-91. PMID 11416218 DOI: 10.1073/Pnas.131202798 |
0.788 |
|
| 2000 |
Mumm JS, Kopan R. Notch signaling: from the outside in. Developmental Biology. 228: 151-65. PMID 11112321 DOI: 10.1006/dbio.2000.9960 |
0.375 |
|
| 2000 |
Mumm JS, Schroeter EH, Saxena MT, Griesemer A, Tian X, Pan DJ, Ray WJ, Kopan R. A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. Molecular Cell. 5: 197-206. PMID 10882062 DOI: 10.1016/S1097-2765(00)80416-5 |
0.797 |
|
| 2000 |
Huppert SS, Le A, Schroeter EH, Mumm JS, Saxena MT, Milner LA, Kopan R. Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Nature. 405: 966-70. PMID 10879540 DOI: 10.1038/35016111 |
0.819 |
|
| 2000 |
Lin MH, Leimeister C, Gessler M, Kopan R. Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers. Development (Cambridge, England). 127: 2421-32. PMID 10804183 |
0.324 |
|
| 2000 |
Huppert SS, Le A, Schroeter EH, Mumm JS, Saxena MT, Milner LA, Kopan R. Erratum: Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1 Nature. 408: 616-616. DOI: 10.1038/35046136 |
0.765 |
|
| 2000 |
Kopan R, Mumm JS, Schroeter EH, Saxena MT, Ray WJ, Goate AM. The next step in notch processing and its relevance to APP biology Neurobiology of Aging. 21: 4. DOI: 10.1016/S0197-4580(00)82693-7 |
0.759 |
|
| 2000 |
Ray WJ, Brunkan A, Schroeter EH, Kopan R, Goate AM. APP and notch proteolysis by γ-secretase requires that these substrates complex with PS1 Neurobiology of Aging. 21: 184. DOI: 10.1016/S0197-4580(00)82169-7 |
0.748 |
|
| 1999 |
Kopan R. All good things must come to an end: how is Notch signaling turned off? Science's Stke : Signal Transduction Knowledge Environment. 1999: PE1. PMID 11865186 DOI: 10.1126/stke.1999.9.pe1 |
0.424 |
|
| 1999 |
Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, Wolfe M, Selkoe DJ, Kopan R, Goate AM. Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch. The Journal of Biological Chemistry. 274: 36801-7. PMID 10593990 DOI: 10.1074/Jbc.274.51.36801 |
0.768 |
|
| 1999 |
Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, et al. A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. The Journal of Biological Chemistry. 274: 28669-73. PMID 10497236 DOI: 10.1074/Jbc.274.40.28669 |
0.636 |
|
| 1999 |
De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 398: 518-22. PMID 10206645 DOI: 10.1038/19083 |
0.806 |
|
| 1999 |
Wittenberger T, Steinbach OC, Authaler A, Kopan R, Rupp RA. MyoD stimulates delta-1 transcription and triggers notch signaling in the Xenopus gastrula. The Embo Journal. 18: 1915-22. PMID 10202155 DOI: 10.1093/emboj/18.7.1915 |
0.739 |
|
| 1999 |
Ray WJ, Yao M, Nowotny P, Mumm J, Zhang W, Wu JY, Kopan R, Goate AM. Evidence for a physical interaction between presenilin and Notch. Proceedings of the National Academy of Sciences of the United States of America. 96: 3263-8. PMID 10077672 DOI: 10.1073/Pnas.96.6.3263 |
0.418 |
|
| 1998 |
Schroeter EH, Kisslinger JA, Kopan R. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature. 393: 382-6. PMID 9620803 DOI: 10.1038/30756 |
0.788 |
|
| 1996 |
Kopan R, Turner DL. The Notch pathway: democracy and aristocracy in the selection of cell fate. Current Opinion in Neurobiology. 6: 594-601. PMID 8937822 DOI: 10.1016/S0959-4388(96)80090-0 |
0.54 |
|
| 1996 |
Milner LA, Bigas A, Kopan R, Brashem-Stein C, Bernstein ID, Martin DI. Inhibition of granulocytic differentiation by mNotch1. Proceedings of the National Academy of Sciences of the United States of America. 93: 13014-9. PMID 8917536 DOI: 10.1073/pnas.93.23.13014 |
0.411 |
|
| 1996 |
Kopan R, Schroeter EH, Weintraub H, Nye JS. Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. Proceedings of the National Academy of Sciences of the United States of America. 93: 1683-8. PMID 8643690 DOI: 10.1073/Pnas.93.4.1683 |
0.81 |
|
| 1995 |
Nye JS, Kopan R. Developmental signaling. Vertebrate ligands for Notch. Current Biology : Cb. 5: 966-9. PMID 8542284 DOI: 10.1016/S0960-9822(95)00189-8 |
0.4 |
|
| 1995 |
Jarriault S, Brou C, Logeat F, Schroeter EH, Kopan R, Israel A. Signalling downstream of activated mammalian Notch. Nature. 377: 355-8. PMID 7566092 DOI: 10.1038/377355A0 |
0.791 |
|
| 1994 |
Kopan R, Nye JS, Weintraub H. The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD. Development (Cambridge, England). 120: 2385-96. PMID 7956819 |
0.538 |
|
| 1994 |
Milner LA, Kopan R, Martin DI, Bernstein ID. A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors. Blood. 83: 2057-62. PMID 7512837 DOI: 10.1182/Blood.V83.8.2057.Bloodjournal8382057 |
0.341 |
|
| 1993 |
Kopan R, Weintraub H. Mouse notch: expression in hair follicles correlates with cell fate determination. The Journal of Cell Biology. 121: 631-41. PMID 8486742 DOI: 10.1083/Jcb.121.3.631 |
0.575 |
|
| 1989 |
Kopan R, Fuchs E. A new look into an old problem: keratins as tools to investigate determination, morphogenesis, and differentiation in skin. Genes & Development. 3: 1-15. PMID 2468556 DOI: 10.1101/GAD.3.1.1 |
0.343 |
|
| 1988 |
Stoler A, Kopan R, Duvic M, Fuchs E. Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation. The Journal of Cell Biology. 107: 427-46. PMID 2458356 DOI: 10.1083/JCB.107.2.427 |
0.316 |
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