| Year |
Citation |
Score |
| 2023 |
Staerz SD, Lisabeth EM, Njomen E, Dexheimer TS, Neubig RR, Tepe JJ. Development of a Cell-Based AlphaLISA Assay for High-Throughput Screening for Small Molecule Proteasome Modulators. Acs Omega. 8: 15650-15659. PMID 37151549 DOI: 10.1021/acsomega.3c01158 |
0.386 |
|
| 2022 |
Misek SA, Foda BM, Dexheimer TS, Akram M, Conrad SE, Schmidt JC, Neubig RR, Gallo KA. BRAF Inhibitor Resistance Confers Increased Sensitivity to Mitotic Inhibitors. Frontiers in Oncology. 12: 766794. PMID 35444937 DOI: 10.3389/fonc.2022.766794 |
0.51 |
|
| 2021 |
Pisanò CA, Mercatelli D, Mazzocchi M, Brugnoli A, Morella I, Fasano S, Zaveri NT, Brambilla R, O'Keeffe GW, Neubig RR, Morari M. Regulator of G-Protein Signalling 4 (RGS4) negatively modulates nociceptin/orphanin FQ opioid receptor signalling: Implication for l-Dopa-induced dyskinesia. British Journal of Pharmacology. PMID 34767639 DOI: 10.1111/bph.15730 |
0.321 |
|
| 2019 |
Shaw VS, Mohammadi M, Quinn JA, Vashisth H, Neubig RR. An Interhelical Salt Bridge Controls Flexibility and Inhibitor Potency For Regulators of G-protein Signaling (RGS) Proteins 4, 8, and 19. Molecular Pharmacology. PMID 31543506 DOI: 10.1124/mol.119.117176 |
0.444 |
|
| 2018 |
Mohammadi M, Mohammadiarani H, Shaw VS, Neubig RR, Vashisth H. Interplay of Cysteine Exposure and Global Protein Dynamics in Small-molecule Recognition by a Regulator of G-protein Signaling Protein. Proteins. PMID 30521141 DOI: 10.1002/prot.25642 |
0.429 |
|
| 2018 |
Shaw VS, Mohammadiarani H, Vashisth H, Neubig RR. Differential Protein Dynamics of Regulators of G-protein Signaling: Role in Specificity of Small-molecule Inhibitors. Journal of the American Chemical Society. PMID 29460621 DOI: 10.1021/jacs.7b13778 |
0.468 |
|
| 2017 |
Dripps IJ, Boyer BT, Neubig RR, Rice KC, Traynor JR, Jutkiewicz EM. Role of signaling molecules in behaviors mediated by the δ-receptor agonist SNC80. British Journal of Pharmacology. PMID 29278419 DOI: 10.1111/Bph.14131 |
0.359 |
|
| 2017 |
Phan HT, Sjogren B, Neubig RR. Human Missense Mutations in Regulator of G Protein Signaling 2 Affect the Protein Function Through Multiple Mechanisms. Molecular Pharmacology. PMID 28784619 DOI: 10.1124/mol.117.109215 |
0.352 |
|
| 2017 |
Pandey M, Zhang JH, Mishra SK, Adikaram PR, Harris B, Kahler JF, Loshakov A, Sholevar R, Genis A, Kittock C, Kabat J, Ganesan S, Neubig RR, Hoon MA, Simonds WF. A central role for R7bp in the regulation of itch sensation. Pain. PMID 28134655 DOI: 10.1097/J.Pain.0000000000000860 |
0.348 |
|
| 2016 |
Dripps IJ, Wang Q, Neubig RR, Rice KC, Traynor JR, Jutkiewicz EM. The role of regulator of G protein signaling 4 in delta-opioid receptor-mediated behaviors. Psychopharmacology. PMID 27624599 DOI: 10.1007/S00213-016-4432-5 |
0.393 |
|
| 2015 |
Neubig RR. RGS-Insensitive G Proteins as In Vivo Probes of RGS Function. Progress in Molecular Biology and Translational Science. 133: 13-30. PMID 26123300 DOI: 10.1016/bs.pmbts.2015.04.010 |
0.435 |
|
| 2015 |
Sjögren B, Swaney S, Neubig RR. FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex. Plos One. 10: e0123581. PMID 25970626 DOI: 10.1371/journal.pone.0123581 |
0.383 |
|
| 2015 |
Blazer LL, Storaska AJ, Jutkiewicz EM, Turner EM, Calcagno M, Wade SM, Wang Q, Huang XP, Traynor JR, Husbands SM, Morari M, Neubig RR. Selectivity and Anti-Parkinson's Potential of Thiadiazolidinone RGS4 Inhibitors. Acs Chemical Neuroscience. 6: 911-9. PMID 25844489 DOI: 10.1021/Acschemneuro.5B00063 |
0.431 |
|
| 2014 |
Raveh A, Schultz PJ, Aschermann L, Carpenter C, Tamayo-Castillo G, Cao S, Clardy J, Neubig RR, Sherman DH, Sjögren B. Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts. Molecular Pharmacology. 86: 406-16. PMID 25086086 DOI: 10.1124/Mol.114.092403 |
0.462 |
|
| 2014 |
Christopoulos A, Changeux JP, Catterall WA, Fabbro D, Burris TP, Cidlowski JA, Olsen RW, Peters JA, Neubig RR, Pin JP, Sexton PM, Kenakin TP, Ehlert FJ, Spedding M, Langmead CJ. International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands. Pharmacological Reviews. 66: 918-47. PMID 25026896 DOI: 10.1124/Pr.114.008862 |
0.473 |
|
| 2014 |
Parra S, Huang X, Charbeneau RA, Wade SM, Kaur K, Rorabaugh BR, Neubig RR. Conditional disruption of interactions between Gαi2 and regulator of G protein signaling (RGS) proteins protects the heart from ischemic injury. Bmc Pharmacology & Toxicology. 15: 29. PMID 24899231 DOI: 10.1186/2050-6511-15-29 |
0.36 |
|
| 2014 |
Chen B, Siderovski DP, Neubig RR, Lawson MA, Trejo J. Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins. The Journal of Biological Chemistry. 289: 1580-91. PMID 24297163 DOI: 10.1074/Jbc.M113.528273 |
0.376 |
|
| 2013 |
Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, ... ... Neubig RR, et al. The Concise Guide to PHARMACOLOGY 2013/14: overview. British Journal of Pharmacology. 170: 1449-58. PMID 24528237 DOI: 10.1111/Bph.12444 |
0.624 |
|
| 2013 |
Vashisth H, Storaska AJ, Neubig RR, Brooks CL. Conformational dynamics of a regulator of G-protein signaling protein reveals a mechanism of allosteric inhibition by a small molecule. Acs Chemical Biology. 8: 2778-84. PMID 24093330 DOI: 10.1021/Cb400568G |
0.484 |
|
| 2013 |
Storaska AJ, Mei JP, Wu M, Li M, Wade SM, Blazer LL, Sjögren B, Hopkins CR, Lindsley CW, Lin Z, Babcock JJ, McManus OB, Neubig RR. Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay. Cellular Signalling. 25: 2848-55. PMID 24041654 DOI: 10.1016/J.Cellsig.2013.09.007 |
0.464 |
|
| 2013 |
Malik RU, Ritt M, DeVree BT, Neubig RR, Sunahara RK, Sivaramakrishnan S. Detection of G protein-selective G protein-coupled receptor (GPCR) conformations in live cells. The Journal of Biological Chemistry. 288: 17167-78. PMID 23629648 DOI: 10.1074/Jbc.M113.464065 |
0.339 |
|
| 2013 |
Lamberts JT, Smith CE, Li MH, Ingram SL, Neubig RR, Traynor JR. Differential control of opioid antinociception to thermal stimuli in a knock-in mouse expressing regulator of G-protein signaling-insensitive Gαo protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 4369-77. PMID 23467353 DOI: 10.1523/Jneurosci.5470-12.2013 |
0.325 |
|
| 2013 |
Storaska AJ, Neubig RR. NMR methods for detection of small molecule binding to RGS4. Methods in Enzymology. 522: 133-52. PMID 23374184 DOI: 10.1016/B978-0-12-407865-9.00008-X |
0.457 |
|
| 2013 |
Lim WK, Kanelakis KC, Neubig RR. Regulation of G protein signaling by the 70kDa heat shock protein. Cellular Signalling. 25: 389-96. PMID 23153586 DOI: 10.1016/J.Cellsig.2012.11.002 |
0.315 |
|
| 2012 |
Cho H, Kamenyeva O, Yung S, Gao JL, Hwang IY, Park C, Murphy PM, Neubig RR, Kehrl JH. The loss of RGS protein-Gα(i2) interactions results in markedly impaired mouse neutrophil trafficking to inflammatory sites. Molecular and Cellular Biology. 32: 4561-71. PMID 22966200 DOI: 10.1128/MCB.00651-12 |
0.346 |
|
| 2012 |
Sjögren B, Parra S, Heath LJ, Atkins KB, Xie ZJ, Neubig RR. Cardiotonic steroids stabilize regulator of G protein signaling 2 protein levels. Molecular Pharmacology. 82: 500-9. PMID 22695717 DOI: 10.1124/mol.112.079293 |
0.372 |
|
| 2012 |
Turner EM, Blazer LL, Neubig RR, Husbands SM. Small Molecule Inhibitors of Regulator of G Protein Signalling (RGS) Proteins. Acs Medicinal Chemistry Letters. 3: 146-150. PMID 22368763 DOI: 10.1021/ml200263y |
0.464 |
|
| 2011 |
Neubig RR. Major developments in our understanding of G protein-coupled receptors. Advances in Pharmacology (San Diego, Calif.). 62: xv-xvi. PMID 21907904 DOI: 10.1016/B978-0-12-385952-5.00012-9 |
0.36 |
|
| 2011 |
Kaur K, Kehrl JM, Charbeneau RA, Neubig RR. RGS-insensitive Gα subunits: probes of Gα subtype-selective signaling and physiological functions of RGS proteins. Methods in Molecular Biology (Clifton, N.J.). 756: 75-98. PMID 21870221 DOI: 10.1007/978-1-61779-160-4_4 |
0.454 |
|
| 2011 |
Waterson RE, Thompson CG, Mabe NW, Kaur K, Talbot JN, Neubig RR, Rorabaugh BR. Gα(i2)-mediated protection from ischaemic injury is modulated by endogenous RGS proteins in the mouse heart. Cardiovascular Research. 91: 45-52. PMID 21349876 DOI: 10.1093/Cvr/Cvr054 |
0.428 |
|
| 2011 |
Blazer LL, Zhang H, Casey EM, Husbands SM, Neubig RR. A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins. Biochemistry. 50: 3181-92. PMID 21329361 DOI: 10.1021/bi1019622 |
0.479 |
|
| 2010 |
Signarvic RS, Cierniewska A, Stalker TJ, Fong KP, Chatterjee MS, Hess PR, Ma P, Diamond SL, Neubig RR, Brass LF. RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury. Blood. 116: 6092-100. PMID 20852125 DOI: 10.1182/Blood-2010-05-283846 |
0.313 |
|
| 2010 |
Sjögren B, Blazer LL, Neubig RR. Regulators of G protein signaling proteins as targets for drug discovery. Progress in Molecular Biology and Translational Science. 91: 81-119. PMID 20691960 DOI: 10.1016/S1877-1173(10)91004-1 |
0.447 |
|
| 2010 |
Sjögren B, Neubig RR. Thinking outside of the "RGS box": new approaches to therapeutic targeting of regulators of G protein signaling. Molecular Pharmacology. 78: 550-7. PMID 20664002 DOI: 10.1124/mol.110.065219 |
0.467 |
|
| 2010 |
Blazer LL, Roman DL, Chung A, Larsen MJ, Greedy BM, Husbands SM, Neubig RR. Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins. Molecular Pharmacology. 78: 524-33. PMID 20571077 DOI: 10.1124/Mol.110.065128 |
0.727 |
|
| 2010 |
Talbot JN, Jutkiewicz EM, Graves SM, Clemans CF, Nicol MR, Mortensen RM, Huang X, Neubig RR, Traynor JR. RGS inhibition at G(alpha)i2 selectively potentiates 5-HT1A-mediated antidepressant effects. Proceedings of the National Academy of Sciences of the United States of America. 107: 11086-91. PMID 20534514 DOI: 10.1073/Pnas.1000003107 |
0.318 |
|
| 2010 |
Roman DL, Blazer LL, Monroy CA, Neubig RR. Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986. Molecular Pharmacology. 78: 360-5. PMID 20530129 DOI: 10.1124/Mol.109.063388 |
0.703 |
|
| 2010 |
Blazer LL, Roman DL, Muxlow MR, Neubig RR. Use of flow cytometric methods to quantify protein-protein interactions. Current Protocols in Cytometry / Editorial Board, J. Paul Robinson, Managing Editor ... [Et Al.]. Unit 13.11.1-15. PMID 20069525 DOI: 10.1002/0471142956.Cy1311S51 |
0.698 |
|
| 2010 |
Talbot JN, Roman DL, Clark MJ, Roof RA, Tesmer JJ, Neubig RR, Traynor JR. Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Galpha subtype dependent. Journal of Neurochemistry. 112: 1026-34. PMID 20002516 DOI: 10.1111/J.1471-4159.2009.06519.X |
0.69 |
|
| 2009 |
Roman DL, Ota S, Neubig RR. Polyplexed flow cytometry protein interaction assay: a novel high-throughput screening paradigm for RGS protein inhibitors. Journal of Biomolecular Screening. 14: 610-9. PMID 19531661 DOI: 10.1177/1087057109336590 |
0.713 |
|
| 2009 |
Roof RA, Roman DL, Clements ST, Sobczyk-Kojiro K, Blazer LL, Ota S, Mosberg HI, Neubig RR. A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen. Bmc Pharmacology. 9: 9. PMID 19463173 DOI: 10.1186/1471-2210-9-9 |
0.694 |
|
| 2009 |
Goldenstein BL, Nelson BW, Xu K, Luger EJ, Pribula JA, Wald JM, O'Shea LA, Weinshenker D, Charbeneau RA, Huang X, Neubig RR, Doze VA. Regulator of G protein signaling protein suppression of Galphao protein-mediated alpha2A adrenergic receptor inhibition of mouse hippocampal CA3 epileptiform activity. Molecular Pharmacology. 75: 1222-30. PMID 19225179 DOI: 10.1124/Mol.108.054296 |
0.35 |
|
| 2009 |
Evelyn CR, Ferng T, Rojas RJ, Larsen MJ, Sondek J, Neubig RR. High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assay. Journal of Biomolecular Screening. 14: 161-72. PMID 19196702 DOI: 10.1177/1087057108328761 |
0.363 |
|
| 2009 |
Blazer LL, Neubig RR. Small molecule protein-protein interaction inhibitors as CNS therapeutic agents: current progress and future hurdles. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 126-41. PMID 18800065 DOI: 10.1038/npp.2008.151 |
0.456 |
|
| 2008 |
Shankaranarayanan A, Thal DM, Tesmer VM, Roman DL, Neubig RR, Kozasa T, Tesmer JJ. Assembly of high order G alpha q-effector complexes with RGS proteins. The Journal of Biological Chemistry. 283: 34923-34. PMID 18936096 DOI: 10.1074/Jbc.M805860200 |
0.713 |
|
| 2008 |
Bernsteel DJ, Roman DL, Neubig RR. In vitro protein kinase activity measurement by flow cytometry. Analytical Biochemistry. 383: 180-5. PMID 18796290 DOI: 10.1016/J.Ab.2008.08.026 |
0.608 |
|
| 2008 |
Roof RA, Sobczyk-Kojiro K, Turbiak AJ, Roman DL, Pogozheva ID, Blazer LL, Neubig RR, Mosberg HI. Novel peptide ligands of RGS4 from a focused one-bead, one-compound library. Chemical Biology & Drug Design. 72: 111-9. PMID 18637987 DOI: 10.1111/J.1747-0285.2008.00687.X |
0.691 |
|
| 2008 |
Pei J, Dishinger JF, Roman DL, Rungwanitcha C, Neubig RR, Kennedy RT. Microfabricated channel array electrophoresis for characterization and screening of enzymes using RGS-G protein interactions as a model system. Analytical Chemistry. 80: 5225-31. PMID 18465881 DOI: 10.1021/Ac800553G |
0.623 |
|
| 2008 |
Huang X, Charbeneau RA, Fu Y, Kaur K, Gerin I, MacDougald OA, Neubig RR. Resistance to diet-induced obesity and improved insulin sensitivity in mice with a regulator of G protein signaling-insensitive G184S Gnai2 allele. Diabetes. 57: 77-85. PMID 17928396 DOI: 10.2337/Db07-0599 |
0.407 |
|
| 2007 |
Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ. Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. Science (New York, N.Y.). 318: 1923-7. PMID 18096806 DOI: 10.1126/Science.1147554 |
0.362 |
|
| 2007 |
Pin JP, Neubig R, Bouvier M, Devi L, Filizola M, Javitch JA, Lohse MJ, Milligan G, Palczewski K, Parmentier M, Spedding M. International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacological Reviews. 59: 5-13. PMID 17329545 DOI: 10.1124/Pr.59.1.5 |
0.426 |
|
| 2007 |
Fu Y, Huang X, Piao L, Lopatin AN, Neubig RR. Endogenous RGS proteins modulate SA and AV nodal functions in isolated heart: implications for sick sinus syndrome and AV block. American Journal of Physiology. Heart and Circulatory Physiology. 292: H2532-9. PMID 17277016 DOI: 10.1152/Ajpheart.01391.2006 |
0.372 |
|
| 2007 |
Jameson EE, Pei J, Wade SM, Neubig RR, Milligan G, Kennedy RT. Capillary electrophoresis assay for G protein-coupled receptor-mediated GTPase activity. Analytical Chemistry. 79: 1158-63. PMID 17263349 DOI: 10.1021/Ac061099G |
0.435 |
|
| 2007 |
Bodenstein J, Sunahara RK, Neubig RR. N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells. Molecular Pharmacology. 71: 1040-50. PMID 17220356 DOI: 10.1124/Mol.106.029397 |
0.349 |
|
| 2007 |
Roman DL, Talbot JN, Roof RA, Sunahara RK, Traynor JR, Neubig RR. Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay. Molecular Pharmacology. 71: 169-75. PMID 17012620 DOI: 10.1124/Mol.106.028670 |
0.754 |
|
| 2007 |
Roman DL, Talbot JN, Roof RA, Sunahara RK, Traynor JR, Neubig RR. Characterization and mechanistic investigation of CCG‐4986, a small molecule RGS4 inhibitor The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A431 |
0.59 |
|
| 2006 |
Huang X, Fu Y, Charbeneau RA, Saunders TL, Taylor DK, Hankenson KD, Russell MW, D'Alecy LG, Neubig RR. Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele. Molecular and Cellular Biology. 26: 6870-9. PMID 16943428 DOI: 10.1128/Mcb.00314-06 |
0.384 |
|
| 2006 |
Roof RA, Jin Y, Roman DL, Sunahara RK, Ishii M, Mosberg HI, Neubig RR. Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins. Chemical Biology & Drug Design. 67: 266-74. PMID 16629824 DOI: 10.1111/J.1747-0285.2006.00373.X |
0.691 |
|
| 2006 |
Fu Y, Huang X, Zhong H, Mortensen RM, D'Alecy LG, Neubig RR. Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects. Circulation Research. 98: 659-66. PMID 16456099 DOI: 10.1161/01.RES.0000207497.50477.60 |
0.386 |
|
| 2005 |
Traynor JR, Neubig RR. Regulators of G protein signaling & drugs of abuse. Molecular Interventions. 5: 30-41. PMID 15734717 DOI: 10.1124/mi.5.1.7 |
0.31 |
|
| 2005 |
Jameson EE, Roof RA, Whorton MH, Mosberg HI, Sunahara RK, Neubig RR, Kennedy RT. Real-time detection of basal and stimulated G protein GTPase activity using fluorescent GTP analogues Journal of Biological Chemistry. 280: 7712-7719. PMID 15613467 DOI: 10.1074/Jbc.M413810200 |
0.314 |
|
| 2004 |
Jin Y, Zhong H, Omnaas JR, Neubig RR, Mosberg HI. Structure-based design, synthesis, and activity of peptide inhibitors of RGS4 GAP activity. Methods in Enzymology. 389: 266-77. PMID 15313571 DOI: 10.1016/S0076-6879(04)89016-5 |
0.466 |
|
| 2004 |
Fu Y, Zhong H, Nanamori M, Mortensen RM, Huang X, Lan K, Neubig RR. RGS-insensitive G-protein mutations to study the role of endogenous RGS proteins. Methods in Enzymology. 389: 229-43. PMID 15313569 DOI: 10.1016/S0076-6879(04)89014-1 |
0.446 |
|
| 2004 |
Wang Q, Liu M, Kozasa T, Rothstein JD, Sternweis PC, Neubig RR. Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells. The Journal of Biological Chemistry. 279: 28831-4. PMID 15143072 DOI: 10.1074/Jbc.C400105200 |
0.331 |
|
| 2004 |
Clark MJ, Neubig RR, Traynor JR. Endogenous regulator of G protein signaling proteins suppress Galphao-dependent, mu-opioid agonist-mediated adenylyl cyclase supersensitization. The Journal of Pharmacology and Experimental Therapeutics. 310: 215-22. PMID 15014136 DOI: 10.1124/jpet.103.064824 |
0.345 |
|
| 2004 |
Jin Y, Zhong H, Omnaas JR, Neubig RR, Mosberg HI. Structure-based design, synthesis, and pharmacologic evaluation tf peptide RGS4 inhibitors Journal of Peptide Research. 63: 141-146. PMID 15009535 DOI: 10.1111/J.1399-3011.2003.00114.X |
0.483 |
|
| 2004 |
Simons PC, Biggs SM, Waller A, Foutz T, Cimino DF, Guo Q, Neubig RR, Tang WJ, Prossnitz ER, Sklar LA. Real-time analysis of ternary complex on particles: direct evidence for partial agonism at the agonist-receptor-G protein complex assembly step of signal transduction. The Journal of Biological Chemistry. 279: 13514-21. PMID 14726530 DOI: 10.1074/Jbc.M310306200 |
0.385 |
|
| 2003 |
Soyer OS, Dimmic MW, Neubig RR, Goldstein RA. Dimerization in aminergic G-protein-coupled receptors: application of a hidden-site class model of evolution. Biochemistry. 42: 14522-31. PMID 14661965 DOI: 10.1021/Bi035097R |
0.307 |
|
| 2003 |
Simons PC, Shi M, Foutz T, Cimino DF, Lewis J, Buranda T, Lim WK, Neubig RR, McIntire WE, Garrison J, Prossnitz E, Sklar LA. Ligand-receptor-G-protein molecular assemblies on beads for mechanistic studies and screening by flow cytometry. Molecular Pharmacology. 64: 1227-38. PMID 14573773 DOI: 10.1124/Mol.64.5.1227 |
0.401 |
|
| 2003 |
Goubaeva F, Ghosh M, Malik S, Yang J, Hinkle PM, Griendling KK, Neubig RR, Smrcka AV. Stimulation of cellular signaling and G protein subunit dissociation by G protein betagamma subunit-binding peptides. The Journal of Biological Chemistry. 278: 19634-41. PMID 12649269 DOI: 10.1074/Jbc.M300052200 |
0.395 |
|
| 2003 |
Clark MJ, Harrison C, Zhong H, Neubig RR, Traynor JR. Endogenous RGS protein action modulates mu-opioid signaling through Galphao. Effects on adenylyl cyclase, extracellular signal-regulated kinases, and intracellular calcium pathways. The Journal of Biological Chemistry. 278: 9418-25. PMID 12524446 DOI: 10.1074/jbc.M208885200 |
0.396 |
|
| 2003 |
Zhong H, Wade SM, Woolf PJ, Linderman JJ, Traynor JR, Neubig RR. A spatial focusing model for G protein signals. Regulator of G protein signaling (RGS) protien-mediated kinetic scaffolding. The Journal of Biological Chemistry. 278: 7278-84. PMID 12446706 DOI: 10.1074/Jbc.M208819200 |
0.452 |
|
| 2002 |
Motulsky H, Neubig R. Analyzing radioligand binding data. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 7.5. PMID 18428565 DOI: 10.1002/0471142301.Ns0705S19 |
0.363 |
|
| 2002 |
Neubig RR. Regulators of G protein signaling (RGS proteins): Novel central nervous system drug targets Journal of Peptide Research. 60: 312-316. PMID 12464108 DOI: 10.1034/j.1399-3011.2002.21064.x |
0.422 |
|
| 2002 |
Sarvazyan NA, Lim WK, Neubig RR. Fluorescence analysis of receptor-G protein interactions in cell membranes Biochemistry. 41: 12858-12867. PMID 12379129 DOI: 10.1021/bi026212l |
0.363 |
|
| 2002 |
Neubig RR, Siderovski DP. Regulators of G-protein signalling as new central nervous system drug targets Nature Reviews Drug Discovery. 1: 187-197. PMID 12120503 DOI: 10.1038/Nrd747 |
0.437 |
|
| 2002 |
Chung DA, Wade SM, Fowler CB, Woods DD, Abada PB, Mosberg HI, Neubig RR. Mutagenesis and peptide analysis of the DRY motif in the alpha2A adrenergic receptor: evidence for alternate mechanisms in G protein-coupled receptors. Biochemical and Biophysical Research Communications. 293: 1233-41. PMID 12054508 DOI: 10.1016/S0006-291X(02)00357-1 |
0.347 |
|
| 2002 |
Wang Q, Liu M, Mullah B, Siderovski DP, Neubig RR. Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells Journal of Biological Chemistry. 277: 24949-24958. PMID 12006602 DOI: 10.1074/Jbc.M203802200 |
0.413 |
|
| 2002 |
Chung DA, Zuiderweg ER, Fowler CB, Soyer OS, Mosberg HI, Neubig RR. NMR structure of the second intracellular loop of the alpha 2A adrenergic receptor: evidence for a novel cytoplasmic helix. Biochemistry. 41: 3596-604. PMID 11888275 DOI: 10.1021/Bi015811+ |
0.32 |
|
| 2002 |
Seta K, Nanamori M, Gregory Modrall J, Neubig RR, Sadoshima J. AT1 receptor mutant lacking heterotrimeric G protein coupling activates the Src-Ras-ERK pathway without nuclear translocation of ERKs Journal of Biological Chemistry. 277: 9268-9277. PMID 11777928 DOI: 10.1074/jbc.M109221200 |
0.318 |
|
| 2001 |
Motulsky H, Neubig R. Analyzing radioligand binding data. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Appendix 3H. PMID 18429075 DOI: 10.1002/0471140864.Psa03Hs21 |
0.371 |
|
| 2001 |
Zhong H, Neubig RR. Regulator of G protein signaling proteins: Novel multifunctional drug targets Journal of Pharmacology and Experimental Therapeutics. 297: 837-845. PMID 11356902 |
0.454 |
|
| 2001 |
Bennett TA, Key TA, Gurevich VV, Neubig R, Prossnitz ER, Sklar LA. Real-time analysis of G protein-coupled receptor reconstitution in a solubilized system. The Journal of Biological Chemistry. 276: 22453-60. PMID 11309376 DOI: 10.1074/Jbc.M009679200 |
0.511 |
|
| 2001 |
Lim WK, Neubig RR. Selective inactivation of guanine-nucleotide-binding regulatory protein (G-protein) α and βγ subunits by urea Biochemical Journal. 354: 337-344. PMID 11171112 DOI: 10.1042/0264-6021:3540337 |
0.399 |
|
| 2000 |
Shea LD, Neubig RR, Linderman JJ. Timing is everything the role of kinetics in G protein activation. Life Sciences. 68: 647-58. PMID 11205879 DOI: 10.1016/S0024-3205(00)00977-2 |
0.389 |
|
| 2000 |
Lan KL, Zhong H, Nanamori M, Neubig RR. Rapid kinetics of regulator of G-protein signaling (RGS)-mediated Gα(i) and Gα(o) deactivation: Gα specificity of RGS4 and RGS7 Journal of Biological Chemistry. 275: 33497-33503. PMID 10942773 DOI: 10.1074/jbc.M005785200 |
0.315 |
|
| 1999 |
Wade SM, Lim WK, Lan KL, Chung DA, Nanamori M, Neubig RR. G(i) activator region of {2A)-adrenergic receptors: Distinct basic residues mediate G(i) versus G(s) activation Molecular Pharmacology. 56: 1005-1013. PMID 10531407 DOI: 10.1124/Mol.56.5.1005 |
0.337 |
|
| 1998 |
Lan KL, Sarvazyan NA, Taussig R, Mackenzie RG, DiBello PR, Dohlman HG, Neubig RR. A point mutation in Gα(o) and Gα(i1) blocks interaction with regulator of G protein signaling proteins Journal of Biological Chemistry. 273: 12794-12797. PMID 9582306 DOI: 10.1074/Jbc.273.21.12794 |
0.347 |
|
| 1998 |
Thompson JB, Wade SM, Harrison JK, Salafranca MN, Neubig RR. Cotransfection of second and third intracellular loop fragments inhibit angiotensin AT1a receptor activation of phospholipase C in HEK-293 cells. The Journal of Pharmacology and Experimental Therapeutics. 285: 216-22. PMID 9536013 |
0.327 |
|
| 1998 |
Sarvazyan NA, Neubig RR. Analysis of molecular assemblies by flow cytometry: Determinants of Gi1 α and βγ binding Proceedings of Spie - the International Society For Optical Engineering. 3256: 122-131. DOI: 10.1117/12.307055 |
0.362 |
|
| 1998 |
Neubig RR. Specificity of receptor-G protein coupling: Protein structure and cellular determinants Seminars in Neuroscience. 9: 189-197. DOI: 10.1006/smns.1997.0117 |
0.435 |
|
| 1997 |
Diversé-Pierluissi M, Remmers AE, Neubig RR, Dunlap K. Novel form of crosstalk between G protein and tyrosine kinase pathways. Proceedings of the National Academy of Sciences of the United States of America. 94: 5417-21. PMID 9144252 DOI: 10.1073/Pnas.94.10.5417 |
0.389 |
|
| 1996 |
Wade SM, Scribner MK, Dalman HM, Taylor JM, Neubig RR. Structural requirements for G(o) activation by receptor-derived peptides: Activation and modulation domains of the α2-adrenergic receptor i3c region Molecular Pharmacology. 50: 351-358. PMID 8700143 |
0.328 |
|
| 1996 |
Remmers AE, Neubig RR. Partial G protein activation by fluorescent guanine nucleotide analogs: Evidence for a triphosphate-bound but inactive state Journal of Biological Chemistry. 271: 4791-4797. PMID 8617747 DOI: 10.1074/jbc.271.9.4791 |
0.336 |
|
| 1994 |
Neubig RR. Membrane organization in G-protein mechanisms Faseb Journal. 8: 939-946. PMID 8088459 |
0.42 |
|
| 1994 |
Wade SM, Dalman HM, Yang SZ, Neubig RR. Multisite interactions of receptors and G proteins: Enhanced potency of dimeric receptor peptides in modifying G protein function Molecular Pharmacology. 45: 1191-1197. PMID 8022412 |
0.38 |
|
| 1994 |
Taylor JM, Jacob-Mosier GG, Lawton RG, Remmers AE, Neubig RR. Binding of an alpha 2 adrenergic receptor third intracellular loop peptide to G beta and the amino terminus of G alpha. The Journal of Biological Chemistry. 269: 27618-24. PMID 7961678 |
0.366 |
|
| 1994 |
Taylor JM, Neubig RR. Peptides as probes for G protein signal transduction Cellular Signalling. 6: 841-849. PMID 7718404 DOI: 10.1016/0898-6568(94)90017-5 |
0.455 |
|
| 1993 |
Neubig RR, Sklar LA. Subsecond modulation of formyl peptide-linked guanine nucleotide-binding proteins by guanosine 5′-O-(3-thio)triphosphate in permeabilized neutrophils Molecular Pharmacology. 43: 734-740. PMID 8502230 |
0.436 |
|
| 1993 |
Graeser D, Neubig RR. Compartmentation of receptors and guanine nucleotide-binding proteins in NG108-15 cells: Lack of cross-talk in agonist binding among the α2-adrenergic, muscarinic, and opiate receptors Molecular Pharmacology. 43: 434-443. PMID 8095695 |
0.406 |
|
| 1992 |
Omann GM, Harter JM, Hassan N, Mansfield PJ, Suchard SJ, Neubig RR. A threshold level of coupled G-proteins is required to transduce neutrophil responses. Journal of Immunology (Baltimore, Md. : 1950). 149: 2172-8. PMID 1517577 |
0.372 |
|
| 1991 |
Gerhardt MA, Neubig RR. Multiple Gi protein subtypes regulate a single effector mechanism Molecular Pharmacology. 40: 707-711. PMID 1658606 |
0.35 |
|
| 1991 |
Dalman HM, Neubig RR. Two peptides from the α2a-adrenergic receptor alter receptor G protein coupling by distinct mechanisms Journal of Biological Chemistry. 266: 11025-11029. PMID 1645720 |
0.374 |
|
| 1990 |
Graeser CA, Neubig RR. Cross-talk: Effects of agonist binding and receptor/G-protein coupling European Journal of Pharmacology. 183: 2154. DOI: 10.1016/0014-2999(90)93678-J |
0.362 |
|
| 1988 |
Thomsen WJ, Jacquez JA, Neubig RR. Inhibition of adenylate cyclase is mediated by the high affinity conformation of the alpha 2-adrenergic receptor. Molecular Pharmacology. 34: 814-22. PMID 2904647 |
0.314 |
|
| 1988 |
Neubig RR, Gantzos RD, Thomson WJ. Mechanism of Agonist and Antagonist Binding to α2 Adrenergic Receptors: Evidence for a Precoupled Receptor-Guanine Nucleotide Protein Complex Biochemistry®. 27: 2374-2384. PMID 2838071 |
0.316 |
|
| 1987 |
Van Dort M, Neubig R, Counsell RE. Radioiodinated p-iodoclonidine: a high-affinity probe for the alpha 2-adrenergic receptor. Journal of Medicinal Chemistry. 30: 1241-4. PMID 3037080 DOI: 10.1021/Jm00390A021 |
0.344 |
|
| 1987 |
Kim MH, Neubig RR. Membrane reconstitution of high-affinity α2 adrenergic agonist binding with guanine nucleotide regulatory proteins Biochemistry. 26: 3664-3672. PMID 2888480 |
0.303 |
|
| 1982 |
Neubig RR, Boyd ND, Cohen JB. Conformations of Torpedo acetylcholine receptor associated with ion transport and desensitization. Biochemistry. 21: 3460-7. PMID 7115680 DOI: 10.1021/Bi00257A032 |
0.34 |
|
| 1981 |
Froehner SC, Gulbrandsen V, Hyman C, Jeng AY, Neubig RR, Cohen JB. Immunofluorescence localization at the mammalian neuromuscular junction of the Mr 43,000 protein of Torpedo postsynaptic membranes. Proceedings of the National Academy of Sciences of the United States of America. 78: 5230-4. PMID 7029531 DOI: 10.1073/Pnas.78.8.5230 |
0.445 |
|
| 1980 |
Neubig RR, Cohen JB. Permeability control by cholinergic receptors in Torpedo postsynaptic membranes: agonist dose-response relations measured at second and millisecond times. Biochemistry. 19: 2770-9. PMID 7397104 DOI: 10.1021/Bi00553A036 |
0.401 |
|
| 1979 |
Neubig RR, Cohen JB. Equilibrium binding of [3H]tubocurarine and [3H]acetylcholine by Torpedo postsynaptic membranes: stoichiometry and ligand interactions. Biochemistry. 18: 5464-75. PMID 518850 DOI: 10.1021/Bi00591A032 |
0.392 |
|
| 1979 |
Neubig RR, Krodel EK, Boyd ND, Cohen JB. Acetylcholine and local anesthetic binding to Torpedo nicotinic postsynaptic membranes after removal of nonreceptor peptides. Proceedings of the National Academy of Sciences of the United States of America. 76: 690-4. PMID 34154 DOI: 10.1073/Pnas.76.2.690 |
0.389 |
|
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