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Eric Boerwinkle - Publications

Affiliations: 
The University of Texas Graduate School of Biomedical Sciences at Houston 
Area:
Genetics, Biostatistics Biology
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291 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Floyd JS, Bloch KM, Brody JA, Maroteau C, Siddiqui MK, Gregory R, Carr DF, Molokhia M, Liu X, Bis JC, Ahmed A, Liu X, Hallberg P, Yue QY, Magnusson PKE, ... ... Boerwinkle E, et al. Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing. Plos One. 14: e0218115. PMID 31242253 DOI: 10.1371/journal.pone.0218115  0.84
2019 Wuttke M, Li Y, Li M, Sieber KB, Feitosa MF, Gorski M, Tin A, Wang L, Chu AY, Hoppmann A, Kirsten H, Giri A, Chai JF, Sveinbjornsson G, Tayo BO, ... ... Boerwinkle E, et al. A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nature Genetics. 51: 957-972. PMID 31152163 DOI: 10.1038/s41588-019-0407-x  0.32
2019 Sung YJ, de Las Fuentes L, Winkler TW, Chasman DI, Bentley AR, Kraja AT, Ntalla I, Warren HR, Guo X, Schwander K, Manning AK, Brown MR, Aschard H, Feitosa MF, Franceschini N, ... ... Boerwinkle E, et al. A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Human Molecular Genetics. PMID 31127295 DOI: 10.1093/hmg/ddz070  0.84
2019 Flannick J, Mercader JM, Fuchsberger C, Udler MS, Mahajan A, Wessel J, Teslovich TM, Caulkins L, Koesterer R, Barajas-Olmos F, Blackwell TW, Boerwinkle E, Brody JA, Centeno-Cruz F, Chen L, et al. Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature. PMID 31118516 DOI: 10.1038/s41586-019-1231-2  0.84
2019 Wang Z, Zhu C, Nambi V, Morrison AC, Folsom AR, Ballantyne CM, Boerwinkle E, Yu B. Metabolomic Pattern Predicts Incident Coronary Heart Disease. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA118312236. PMID 31092011 DOI: 10.1161/ATVBAHA.118.312236  0.84
2019 Shahin MH, Rouby NE, Conrado DJ, Gonzalez D, Gong Y, Lobmeyer MT, Beitelshees AL, Boerwinkle E, Gums JG, Chapman A, Turner ST, Pepine CJ, Cooper-DeHoff RM, Johnson JA. β -Adrenergic Receptor Gene Affects the Heart Rate Response of β-Blockers: Evidence From 3 Clinical Studies. Journal of Clinical Pharmacology. PMID 31090079 DOI: 10.1002/jcph.1443  0.32
2019 Ward-Caviness CK, de Vries PS, Wiggins KL, Huffman JE, Yanek LR, Bielak LF, Giulianini F, Guo X, Kleber ME, Kacprowski T, Groß S, Petersman A, Davey Smith G, Hartwig FP, Bowden J, ... ... Boerwinkle E, et al. Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease. Plos One. 14: e0216222. PMID 31075152 DOI: 10.1371/journal.pone.0216222  0.84
2019 Kapoor A, Lee D, Zhu L, Soliman EZ, Grove ML, Boerwinkle E, Arking DE, Chakravarti A. Multiple variant enhancers modulate its cardiac gene expression and the QT interval. Proceedings of the National Academy of Sciences of the United States of America. PMID 31068470 DOI: 10.1073/pnas.1808734116  0.32
2019 Davies G, Lam M, Harris SE, Trampush JW, Luciano M, Hill WD, Hagenaars SP, Ritchie SJ, Marioni RE, Fawns-Ritchie C, Liewald DCM, Okely JA, Ahola-Olli AV, Barnes CLK, Bertram L, ... ... Boerwinkle E, et al. Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature Communications. 10: 2068. PMID 31043617 DOI: 10.1038/s41467-019-10160-w  0.32
2019 Singh S, El Rouby N, McDonough CW, Gong Y, Bailey KR, Boerwinkle E, Chapman AB, Gums JG, Turner ST, Cooper-DeHoff RM, Johnson JA. Genomic Association Analysis Reveals Variants Associated with Blood Pressure Response to Beta-Blockers in European Americans. Clinical and Translational Science. PMID 31033190 DOI: 10.1111/cts.12643  0.32
2019 Li Z, Li X, Liu Y, Shen J, Chen H, Zhou H, Morrison AC, Boerwinkle E, Lin X. Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole-Genome Sequencing Studies. American Journal of Human Genetics. PMID 30982610 DOI: 10.1016/j.ajhg.2019.03.002  0.84
2019 Yu B, Flexeder C, McGarrah RW, Wyss A, Morrison AC, North KE, Boerwinkle E, Kastenmüller G, Gieger C, Suhre K, Karrasch S, Peters A, Wagner GR, Michelotti GA, Mohney RP, et al. Metabolomics Identifies Novel Blood Biomarkers of Pulmonary Function and COPD in the General Population. Metabolites. 9. PMID 30939782 DOI: 10.3390/metabo9040061  0.84
2019 Bentley AR, Sung YJ, Brown MR, Winkler TW, Kraja AT, Ntalla I, Schwander K, Chasman DI, Lim E, Deng X, Guo X, Liu J, Lu Y, Cheng CY, Sim X, ... ... Boerwinkle E, et al. Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nature Genetics. 51: 636-648. PMID 30926973 DOI: 10.1038/s41588-019-0378-y  0.32
2019 Bryant TS, Duggal P, Yu B, Morrison AC, Shafi T, Ehret G, Franceschini N, Boerwinkle E, Coresh J, Tin A. Association of Variants with Blood Pressure in the Atherosclerosis Risk in Communities Study. International Journal of Hypertension. 2019: 2137629. PMID 30906589 DOI: 10.1155/2019/2137629  0.84
2019 Liu Y, Chen S, Li Z, Morrison AC, Boerwinkle E, Lin X. ACAT: A Fast and Powerful p Value Combination Method for Rare-Variant Analysis in Sequencing Studies. American Journal of Human Genetics. 104: 410-421. PMID 30849328 DOI: 10.1016/j.ajhg.2019.01.002  0.84
2019 Justice AE, Karaderi T, Highland HM, Young KL, Graff M, Lu Y, Turcot V, Auer PL, Fine RS, Guo X, Schurmann C, Lempradl A, Marouli E, Mahajan A, Winkler TW, ... ... Boerwinkle E, et al. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. Nature Genetics. PMID 30778226 DOI: 10.1038/s41588-018-0334-2  0.44
2019 Solayman MH, Langaee TY, Gong Y, Shahin MH, Turner ST, Chapman AB, Gums JG, Boerwinkle E, Beitelshees AL, El-Hamamsy M, El-Wakeel L, Cooper-DeHoff RM, Badary OA, Johnson JA. Effect of plasma MicroRNA on antihypertensive response to beta blockers in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) studies. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 131: 93-98. PMID 30753892 DOI: 10.1016/j.ejps.2019.02.013  0.32
2019 de Vries PS, Brown MR, Bentley AR, Sung YJ, Winkler TW, Ntalla I, Schwander K, Kraja AT, Guo X, Franceschini N, Cheng CY, Sim X, Vojinovic D, Huffman JE, Musani SK, ... ... Boerwinkle E, et al. Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. American Journal of Epidemiology. PMID 30698716 DOI: 10.1093/aje/kwz005  0.84
2019 He KY, Li X, Kelly TN, Liang J, Cade BE, Assimes TL, Becker LC, Beitelshees AL, Bress AP, Chang YC, Chen YI, de Vries PS, Fox ER, Franceschini N, Furniss A, ... ... Boerwinkle E, et al. Leveraging linkage evidence to identify low-frequency and rare variants on 16p13 associated with blood pressure using TOPMed whole genome sequencing data. Human Genetics. PMID 30671673 DOI: 10.1007/s00439-019-01975-0  0.84
2019 Kilpeläinen TO, Bentley AR, Noordam R, Sung YJ, Schwander K, Winkler TW, Jakupović H, Chasman DI, Manning A, Ntalla I, Aschard H, Brown MR, de Las Fuentes L, Franceschini N, Guo X, ... ... Boerwinkle E, et al. Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. Nature Communications. 10: 376. PMID 30670697 DOI: 10.1038/s41467-018-08008-w  0.84
2019 de Vries PS, Sabater-Lleal M, Huffman JE, Marten J, Song C, Pankratz N, Bartz TM, de Haan HG, Delgado GE, Eicher JD, Martinez-Perez A, Ward-Caviness CK, Brody JA, Chen MH, de Maat MPM, ... ... Boerwinkle E, et al. A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology. Blood. PMID 30642921 DOI: 10.1182/blood-2018-05-849240  0.84
2019 Petty LE, Highland HM, Gamazon ER, Hu H, Karhade M, Chen HH, de Vries PS, Grove ML, Aguilar D, Bell GI, Huff CD, Hanis CL, Doddapaneni H, Munzy DM, Gibbs RA, ... ... Boerwinkle E, et al. Functionally oriented analysis of cardiometabolic traits in a trans-ethnic sample. Human Molecular Genetics. PMID 30624610 DOI: 10.1093/hmg/ddy435  0.84
2018 Chen H, Huffman JE, Brody JA, Wang C, Lee S, Li Z, Gogarten SM, Sofer T, Bielak LF, Bis JC, Blangero J, Bowler RP, Cade BE, Cho MH, Correa A, ... ... Boerwinkle E, et al. Efficient Variant Set Mixed Model Association Tests for Continuous and Binary Traits in Large-Scale Whole-Genome Sequencing Studies. American Journal of Human Genetics. PMID 30639324 DOI: 10.1016/j.ajhg.2018.12.012  0.84
2018 Sabater-Lleal M, Huffman JE, de Vries PS, Marten J, Mastrangelo MA, Song C, Pankratz N, Ward-Caviness CK, Yanek LR, Trompet S, Delgado GE, Guo X, Bartz TM, Martinez-Perez A, Germain M, ... ... Boerwinkle E, et al. Genome-Wide Association Trans-Ethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels. Circulation. PMID 30586737 DOI: 10.1161/CIRCULATIONAHA.118.034532  0.84
2018 Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, ... ... Boerwinkle E, et al. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nature Communications. 9: 5141. PMID 30510157 DOI: 10.1038/s41467-018-07340-5  0.84
2018 Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, ... ... Boerwinkle E, et al. Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics. PMID 30429575 DOI: 10.1038/s41588-018-0297-3  0.44
2018 Ligthart S, Vaez A, Võsa U, Stathopoulou MG, de Vries PS, Prins BP, Van der Most PJ, Tanaka T, Naderi E, Rose LM, Wu Y, Karlsson R, Barbalic M, Lin H, Pool R, ... ... Boerwinkle E, et al. Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. American Journal of Human Genetics. 103: 691-706. PMID 30388399 DOI: 10.1016/j.ajhg.2018.09.009  0.84
2018 Singh S, Wang Z, Shahin MH, Langaee TY, Gong Y, Turner ST, Chapman AB, Gums JG, McDonough CW, Bailey KR, Beitelshees AL, Cooper-DeHoff RM, Scherer S, Boerwinkle E, Johnson JA. Targeted sequencing identifies a missense variant in the BEST3 gene associated with antihypertensive response to hydrochlorothiazide. Pharmacogenetics and Genomics. PMID 30289819 DOI: 10.1097/FPC.0000000000000353  0.32
2018 Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, ... ... Boerwinkle E, et al. Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics. PMID 30224653 DOI: 10.1038/s41588-018-0205-x  0.32
2018 Nandakumar P, Morrison AC, Grove ML, Boerwinkle E, Chakravarti A. Contributions of rare coding variants in hypotension syndrome genes to population blood pressure variation. Medicine. 97: e11865. PMID 30113482 DOI: 10.1097/MD.0000000000011865  0.84
2018 van Setten J, Brody JA, Jamshidi Y, Swenson BR, Butler AM, Campbell H, Del Greco FM, Evans DS, Gibson Q, Gudbjartsson DF, Kerr KF, Krijthe BP, Lyytikäinen LP, Müller C, Müller-Nurasyid M, ... ... Boerwinkle E, et al. PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity. Nature Communications. 9: 2904. PMID 30046033 DOI: 10.1038/s41467-018-04766-9  0.44
2018 Ward-Caviness CK, Huffman JE, Evertt K, Germain M, Van Dongen J, Hill WD, Jhun MA, Brody JA, Ghanbari M, Du L, Roetker NS, de Vries PS, Waldenberger M, Gieger C, Wolf P, ... ... Boerwinkle E, et al. DNA methylation age is associated with an altered hemostatic profile in a multi-ethnic meta-analysis. Blood. PMID 30042098 DOI: 10.1182/blood-2018-02-831347  0.84
2018 Jian X, Satizabal CL, Smith AV, Wittfeld K, Bis JC, Smith JA, Hsu FC, Nho K, Hofer E, Hagenaars SP, Nyquist PA, Mishra A, Adams HHH, Li S, Teumer A, ... ... Boerwinkle E, et al. Exome Chip Analysis Identifies Low-Frequency and Rare Variants in for White Matter Hyperintensities on Brain Magnetic Resonance Imaging. Stroke. PMID 30002152 DOI: 10.1161/STROKEAHA.118.020689  0.32
2018 Sá ACC, Webb A, Gong Y, McDonough CW, Shahin MH, Datta S, Langaee TY, Turner ST, Beitelshees AL, Chapman AB, Boerwinkle E, Gums JG, Scherer SE, Cooper-DeHoff RM, Sadee W, et al. Blood pressure signature genes and blood pressure response to thiazide diuretics: results from the PEAR and PEAR-2 studies. Bmc Medical Genomics. 11: 55. PMID 29925376 DOI: 10.1186/s12920-018-0370-x  0.32
2018 Feitosa MF, Kraja AT, Chasman DI, Sung YJ, Winkler TW, Ntalla I, Guo X, Franceschini N, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Li C, Bentley AR, ... ... Boerwinkle E, et al. Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. Plos One. 13: e0198166. PMID 29912962 DOI: 10.1371/journal.pone.0198166  0.84
2018 Davies G, Lam M, Harris SE, Trampush JW, Luciano M, Hill WD, Hagenaars SP, Ritchie SJ, Marioni RE, Fawns-Ritchie C, Liewald DCM, Okely JA, Ahola-Olli AV, Barnes CLK, Bertram L, ... ... Boerwinkle E, et al. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature Communications. 9: 2098. PMID 29844566 DOI: 10.1038/s41467-018-04362-x  0.32
2018 Macri V, Brody JA, Arking DE, Hucker WJ, Yin X, Lin H, Mills RW, Sinner MF, Lubitz SA, Liu CT, Morrison AC, Alonso A, Li N, Fedorov VV, Janssen PM, ... ... Boerwinkle E, et al. Common Coding Variants in Are Associated With the Nav1.8 Late Current and Cardiac Conduction. Circulation. Genomic and Precision Medicine. 11: e001663. PMID 29752399 DOI: 10.1161/CIRCGEN.116.001663  0.84
2018 Liang J, Le TH, Velez Edwards DR, Tayo BO, Gaulton KJ, Smith JA, Lu Y, Jensen RA, Chen G, Yanek LR, Schwander K, Tajuddin SM, Sofer T, Kim W, Kayima J, ... ... Boerwinkle E, et al. Correction: Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations. Plos Genetics. 14: e1007345. PMID 29750786 DOI: 10.1371/journal.pgen.1007345  0.84
2018 McDonough CW, Magvanjav O, Sá ACC, El Rouby NM, Dave C, Deitchman AN, Kawaguchi-Suzuki M, Mei W, Shen Y, Singh RSP, Solayman M, Bailey KR, Boerwinkle E, Chapman AB, Gums JG, et al. Genetic Variants Influencing Plasma Renin Activity in Hypertensive Patients From the PEAR Study (Pharmacogenomic Evaluation of Antihypertensive Responses). Circulation. Genomic and Precision Medicine. 11: e001854. PMID 29650764 DOI: 10.1161/CIRCGEN.117.001854  0.32
2018 Mahajan A, Wessel J, Willems SM, Zhao W, Robertson NR, Chu AY, Gan W, Kitajima H, Taliun D, Rayner NW, Guo X, Lu Y, Li M, Jensen RA, Hu Y, ... ... Boerwinkle E, et al. Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nature Genetics. 50: 559-571. PMID 29632382 DOI: 10.1038/s41588-018-0084-1  0.44
2018 Feofanova EV, Yu B, Metcalf GA, Liu X, Muzny D, Below JE, Wagenknecht LE, Gibbs RA, Morrison AC, Boerwinkle E. Sequence-Based Analysis of Lipid-Related Metabolites in a Multiethnic Study. Genetics. PMID 29610217 DOI: 10.1534/genetics.118.300751  0.84
2018 Roetker NS, Pankow JS, Bressler J, Morrison AC, Boerwinkle E. Prospective Study of Epigenetic Age Acceleration and Incidence of Cardiovascular Disease Outcomes in the ARIC Study (Atherosclerosis Risk in Communities). Circulation. Genomic and Precision Medicine. 11: e001937. PMID 29555670 DOI: 10.1161/CIRCGEN.117.001937  0.84
2018 Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, ... ... Boerwinkle E, et al. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nature Genetics. PMID 29549329 DOI: 10.1038/s41588-018-0050-y  0.44
2018 Singh S, McDonough CW, Gong Y, Alghamdi WA, Arwood MJ, Bargal SA, Dumeny L, Li WY, Mehanna M, Stockard B, Yang G, de Oliveira FA, Fredette NC, Shahin MH, Bailey KR, ... ... Boerwinkle E, et al. Genome Wide Association Study Identifies theLocus to be Associated With Chlorthalidone Induced Glucose Increase in Hypertensive Patients. Journal of the American Heart Association. 7. PMID 29523524 DOI: 10.1161/JAHA.117.007339  0.32
2018 Shahin MH, Conrado DJ, Gonzalez D, Gong Y, Lobmeyer MT, Beitelshees AL, Boerwinkle E, Gums JG, Chapman A, Turner ST, Cooper-DeHoff RM, Johnson JA. Genome-Wide Association Approach Identified Novel Genetic Predictors of Heart Rate Response to β-Blockers. Journal of the American Heart Association. 7. PMID 29478026 DOI: 10.1161/JAHA.117.006463  0.32
2018 Guo L, Akahori H, Harari E, Smith SL, Polavarapu R, Karmali V, Otsuka F, Gannon RL, Braumann RE, Dickinson MH, Gupta A, Jenkins AL, Lipinski MJ, Kim J, Chhour P, ... ... Boerwinkle E, et al. CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis. The Journal of Clinical Investigation. PMID 29457790 DOI: 10.1172/JCI93025  0.84
2018 Sung YJ, Winkler TW, de Las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I, Guo X, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, ... ... Boerwinkle E, et al. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. American Journal of Human Genetics. PMID 29455858 DOI: 10.1016/j.ajhg.2018.01.015  0.44
2018 Jiang X, O'Reilly PF, Aschard H, Hsu YH, Richards JB, Dupuis J, Ingelsson E, Karasik D, Pilz S, Berry D, Kestenbaum B, Zheng J, Luan J, Sofianopoulou E, Streeten EA, ... ... Boerwinkle E, et al. Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. Nature Communications. 9: 260. PMID 29343764 DOI: 10.1038/s41467-017-02662-2  0.44
2018 Hong J, Hatchell KE, Bradfield JP, Andrew B, Alessandra C, Chao-Qiang L, Langefeld CD, Lu L, Lu Y, Lutsey PL, Musani SK, Nalls MA, Robinson-Cohen C, Roizen JD, Saxena R, ... ... Boerwinkle E, et al. Trans-ethnic Evaluation Identifies Novel Low Frequency Loci Associated with 25-Hydroxyvitamin D Concentrations. The Journal of Clinical Endocrinology and Metabolism. PMID 29325163 DOI: 10.1210/jc.2017-01802  0.44
2018 Sanner J, Grove ML, Yu E, Moeller FG, Cron SG, Boerwinkle E, Morrison AC, Frazier L. Effects of Gender-Specific Differences, Inflammatory Response, and Genetic Variation on the Associations Among Depressive Symptoms and the Risk of Major Adverse Coronary Events in Patients With Acute Coronary Syndrome. Biological Research For Nursing. 1099800417751662. PMID 29298497 DOI: 10.1177/1099800417751662  0.84
2018 Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, ... ... Boerwinkle E, et al. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nature Genetics. 50: 26-41. PMID 29273807 DOI: 10.1038/s41588-017-0011-x  0.44
2017 Shahin MH, Gong Y, Frye RF, Rotroff DM, Beitelshees AL, Baillie RA, Chapman AB, Gums JG, Turner ST, Boerwinkle E, Motsinger-Reif A, Fiehn O, Cooper-DeHoff RM, Han X, Kaddurah-Daouk R, et al. Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics. Journal of the American Heart Association. 7. PMID 29288159 DOI: 10.1161/JAHA.117.006656  0.32
2017 Smith JA, Zhao W, Yasutake K, August C, Ratliff SM, Faul JD, Boerwinkle E, Chakravarti A, Diez Roux AV, Gao Y, Griswold ME, Heiss G, Kardia SLR, Morrison AC, Musani SK, et al. Gene-by-Psychosocial Factor Interactions Influence Diastolic Blood Pressure in European and African Ancestry Populations: Meta-Analysis of Four Cohort Studies. International Journal of Environmental Research and Public Health. 14. PMID 29258278 DOI: 10.3390/ijerph14121596  0.84
2017 Richard MA, Huan T, Ligthart S, Gondalia R, Jhun MA, Brody JA, Irvin MR, Marioni R, Shen J, Tsai PC, Montasser ME, Jia Y, Syme C, Salfati EL, Boerwinkle E, et al. DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation. American Journal of Human Genetics. 101: 888-902. PMID 29198723 DOI: 10.1016/j.ajhg.2017.09.028  0.84
2017 Sá ACC, Webb A, Gong Y, McDonough CW, Datta S, Langaee TY, Turner ST, Beitelshees AL, Chapman AB, Boerwinkle E, Gums JG, Scherer SE, Cooper-DeHoff RM, Sadee W, Johnson JA. Whole Transcriptome Sequencing Analyses Reveal Molecular Markers of Blood Pressure Response to Thiazide Diuretics. Scientific Reports. 7: 16068. PMID 29167564 DOI: 10.1038/s41598-017-16343-z  0.32
2017 Magvanjav O, Gong Y, McDonough CW, Chapman AB, Turner ST, Gums JG, Bailey KR, Boerwinkle E, Beitelshees AL, Tanaka T, Kubo M, Pepine CJ, Cooper-DeHoff RM, Johnson JA. Genetic Variants Associated With Uncontrolled Blood Pressure on Thiazide Diuretic/β-Blocker Combination Therapy in the PEAR (Pharmacogenomic Evaluation of Antihypertensive Responses) and INVEST (International Verapamil-SR Trandolapril Study) Trials. Journal of the American Heart Association. 6. PMID 29097388 DOI: 10.1161/JAHA.117.006522  0.32
2017 Brody JA, Morrison AC, Bis JC, O'Connell JR, Brown MR, Huffman JE, Ames DC, Carroll A, Conomos MP, Gabriel S, Gibbs RA, Gogarten SM, Gupta N, Jaquish CE, Johnson AD, ... ... Boerwinkle E, et al. Analysis commons, a team approach to discovery in a big-data environment for genetic epidemiology. Nature Genetics. 49: 1560-1563. PMID 29074945 DOI: 10.1038/ng.3968  0.84
2017 Kraja AT, Cook JP, Warren HR, Surendran P, Liu C, Evangelou E, Manning AK, Grarup N, Drenos F, Sim X, Smith AV, Amin N, Blakemore AIF, Bork-Jensen J, Brandslund I, ... ... Boerwinkle E, et al. New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals. Circulation. Cardiovascular Genetics. 10. PMID 29030403 DOI: 10.1161/CIRCGENETICS.117.001778  0.84
2017 Graff M, Emery LS, Justice AE, Parra E, Below JE, Palmer ND, Gao C, Duan Q, Valladares-Salgado A, Cruz M, Morrison AC, Boerwinkle E, Whitsel EA, Kooperberg C, Reiner A, et al. Genetic architecture of lipid traits in the Hispanic community health study/study of Latinos. Lipids in Health and Disease. 16: 200. PMID 29025430 DOI: 10.1186/s12944-017-0591-6  0.84
2017 de Vries PS, Yu B, Feofanova EV, Metcalf GA, Brown MR, Zeighami AL, Liu X, Muzny DM, Gibbs RA, Boerwinkle E, Morrison AC. Whole-genome sequencing study of serum peptide levels: the Atherosclerosis Risk in Communities study. Human Molecular Genetics. 26: 3442-3450. PMID 28854705 DOI: 10.1093/hmg/ddx266  0.84
2017 Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L, Winkler TW, Chu AY, Mahajan A, Hadley D, Xue L, Workalemahu T, Heard-Costa NL, den Hoed M, Ahluwalia TS, ... ... Boerwinkle E, et al. Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. Plos Genetics. 13: e1006972. PMID 28832619 DOI: 10.1371/journal.pgen.1006972  0.44
2017 Nandakumar P, Tin A, Grove ML, Ma J, Boerwinkle E, Coresh J, Chakravarti A. MicroRNAs in the miR-17 and miR-15 families are downregulated in chronic kidney disease with hypertension. Plos One. 12: e0176734. PMID 28771472 DOI: 10.1371/journal.pone.0176734  0.32
2017 Li M, Maruthur NM, Loomis SJ, Pietzner M, North KE, Mei H, Morrison AC, Friedrich N, Pankow JS, Nauck M, Boerwinkle E, Teumer A, Selvin E, Köttgen A. Genome-wide association study of 1,5-anhydroglucitol identifies novel genetic loci linked to glucose metabolism. Scientific Reports. 7: 2812. PMID 28588231 DOI: 10.1038/s41598-017-02287-x  0.84
2017 Gorski M, Most PJV, Teumer A, Chu AY, Li M, Mijatovic V, Nolte IM, Cocca M, Taliun D, Gomez F, Li Y, Tayo B, Tin A, Feitosa MF, Aspelund T, ... ... Boerwinkle E, et al. Corrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. Scientific Reports. 7: 46835. PMID 28548086 DOI: 10.1038/srep46835  0.44
2017 Liang J, Le TH, Edwards DRV, Tayo BO, Gaulton KJ, Smith JA, Lu Y, Jensen RA, Chen G, Yanek LR, Schwander K, Tajuddin SM, Sofer T, Kim W, Kayima J, ... ... Boerwinkle E, et al. Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations. Plos Genetics. 13: e1006728. PMID 28498854 DOI: 10.1371/journal.pgen.1006728  0.84
2017 Gorski M, van der Most PJ, Teumer A, Chu AY, Li M, Mijatovic V, Nolte IM, Cocca M, Taliun D, Gomez F, Li Y, Tayo B, Tin A, Feitosa MF, Aspelund T, ... ... Boerwinkle E, et al. 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. Scientific Reports. 7: 45040. PMID 28452372 DOI: 10.1038/srep45040  0.44
2017 Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L, Winkler TW, Chu AY, Mahajan A, Hadley D, Xue L, Workalemahu T, Heard-Costa NL, den Hoed M, Ahluwalia TS, ... ... Boerwinkle E, et al. Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. Plos Genetics. 13: e1006528. PMID 28448500 DOI: 10.1371/journal.pgen.1006528  0.44
2017 Justice AE, Winkler TW, Feitosa MF, Graff M, Fisher VA, Young K, Barata L, Deng X, Czajkowski J, Hadley D, Ngwa JS, Ahluwalia TS, Chu AY, Heard-Costa NL, Lim E, ... ... Boerwinkle E, et al. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nature Communications. 8: 14977. PMID 28443625 DOI: 10.1038/ncomms14977  0.32
2017 Day FR, Thompson DJ, Helgason H, Chasman DI, Finucane H, Sulem P, Ruth KS, Whalen S, Sarkar AK, Albrecht E, Altmaier E, Amini M, Barbieri CM, Boutin T, Campbell A, ... ... Boerwinkle E, et al. Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nature Genetics. PMID 28436984 DOI: 10.1038/ng.3841  0.44
2017 Böger CA, Gorski M, McMahon GM, Xu H, Chang YC, van der Most PJ, Navis G, Nolte IM, de Borst MH, Zhang W, Lehne B, Loh M, Tan ST, Boerwinkle E, Grams ME, et al. NFAT5 and SLC4A10 Loci Associate with Plasma Osmolality. Journal of the American Society of Nephrology : Jasn. PMID 28360221 DOI: 10.1681/ASN.2016080892  0.32
2017 Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y, Schurmann C, Highland HM, Rüeger S, Thorleifsson G, Justice AE, Lamparter D, Stirrups KE, ... ... Boerwinkle E, et al. Rare and low-frequency coding variants alter human adult height. Nature. PMID 28146470 DOI: 10.1038/nature21039  0.44
2017 Shahin MH, Sá AC, Webb A, Gong Y, Langaee T, McDonough CW, Riva A, Beitleshees AL, Chapman AB, Gums JG, Turner ST, Boerwinkle E, Scherer SE, Sadee W, Cooper-DeHoff RM, et al. Genome-Wide Prioritization and Transcriptomics Reveal Novel Signatures Associated With Thiazide Diuretics Blood Pressure Response. Circulation. Cardiovascular Genetics. 10. PMID 28115488 DOI: 10.1161/CIRCGENETICS.116.001404  0.32
2017 Morrison AC, Huang Z, Yu B, Metcalf G, Liu X, Ballantyne C, Coresh J, Yu F, Muzny D, Feofanova E, Rustagi N, Gibbs R, Boerwinkle E. Practical Approaches for Whole-Genome Sequence Analysis of Heart- and Blood-Related Traits. American Journal of Human Genetics. PMID 28089252 DOI: 10.1016/j.ajhg.2016.12.009  0.84
2016 Weng L, Gong Y, Culver J, Gardell SJ, Petucci C, Morse AM, Frye RF, Turner ST, Chapman A, Boerwinkle E, Gums J, Beitelshees AL, Borum PR, Johnson JA, Garrett TJ, et al. Presence of arachidonoyl-carnitine is associated with adverse cardiometabolic responses in hypertensive patients treated with atenolol. Metabolomics : Open Access. 12. PMID 28217401 DOI: 10.1007/s11306-016-1098-2  0.32
2016 de Oliveira FA, Shahin MH, Gong Y, McDonough CW, Beitelshees AL, Gums JG, Chapman AB, Boerwinkle E, Turner ST, Frye RF, Fiehn O, Kaddurah-Daouk R, Johnson JA, Cooper-DeHoff RM. Novel plasma biomarker of atenolol-induced hyperglycemia identified through a metabolomics-genomics integrative approach. Metabolomics : Open Access. 12. PMID 28217400 DOI: 10.1007/s11306-016-1076-8  0.32
2016 Ligthart S, Marzi C, Aslibekyan S, Mendelson MM, Conneely KN, Tanaka T, Colicino E, Waite LL, Joehanes R, Guan W, Brody JA, Elks C, Marioni R, Jhun MA, Agha G, ... ... Boerwinkle E, et al. DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome Biology. 17: 255. PMID 27955697 DOI: 10.1186/s13059-016-1119-5  0.32
2016 Li M, Li Y, Weeks O, Mijatovic V, Teumer A, Huffman JE, Tromp G, Fuchsberger C, Gorski M, Lyytikäinen LP, Nutile T, Sedaghat S, Sorice R, Tin A, Yang Q, ... ... Boerwinkle E, et al. SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. Journal of the American Society of Nephrology : Jasn. PMID 27920155 DOI: 10.1681/ASN.2016020131  0.44
2016 Yu B, de Vries PS, Metcalf GA, Wang Z, Feofanova EV, Liu X, Muzny DM, Wagenknecht LE, Gibbs RA, Morrison AC, Boerwinkle E. Whole genome sequence analysis of serum amino acid levels. Genome Biology. 17: 237. PMID 27884205 DOI: 10.1186/s13059-016-1106-x  0.84
2016 Natarajan P, Bis JC, Bielak LF, Cox AJ, Dörr M, Feitosa MF, Franceschini N, Guo X, Hwang SJ, Isaacs A, Jhun MA, Kavousi M, Li-Gao R, Lyytikäinen LP, Marioni RE, ... ... Boerwinkle E, et al. Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis. Circulation. Cardiovascular Genetics. PMID 27872105 DOI: 10.1161/CIRCGENETICS.116.001572  0.32
2016 Salvi E, Wang Z, Rizzi F, Gong Y, McDonough CW, Padmanabhan S, Hiltunen TP, Lanzani C, Zaninello R, Chittani M, Bailey KR, Sarin AP, Barcella M, Melander O, Chapman AB, ... ... Boerwinkle E, et al. Genome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to Hydrochlorothiazide. Hypertension (Dallas, Tex. : 1979). PMID 27802415 DOI: 10.1161/HYPERTENSIONAHA.116.08267  0.32
2016 Liu C, Kraja AT, Smith JA, Brody JA, Franceschini N, Bis JC, Rice K, Morrison AC, Lu Y, Weiss S, Guo X, Palmas W, Martin LW, Chen YI, Surendran P, ... ... Boerwinkle E, et al. Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci. Nature Genetics. PMID 27618448 DOI: 10.1038/ng.3660  0.84
2016 Yu B, Li AH, Metcalf GA, Muzny DM, Morrison AC, White S, Mosley TH, Gibbs RA, Boerwinkle E. Loss-of-function variants influence the human serum metabolome. Science Advances. 2: e1600800. PMID 27602404 DOI: 10.1126/sciadv.1600800  0.84
2016 Postmus I, Warren HR, Trompet S, Arsenault BJ, Avery CL, Bis JC, Chasman DI, de Keyser CE, Deshmukh HA, Evans DS, Feng Q, Li X, Smit RA, Smith AV, Sun F, ... ... Boerwinkle E, et al. Meta-analysis of genome-wide association studies of HDL cholesterol response to statins. Journal of Medical Genetics. PMID 27587472 DOI: 10.1136/jmedgenet-2016-103966  0.32
2016 Rhee EP, Yang Q, Yu B, Liu X, Cheng S, Deik A, Pierce KA, Bullock K, Ho JE, Levy D, Florez JC, Kathiresan S, Larson MG, Vasan RS, Clish CB, ... ... Boerwinkle E, et al. An exome array study of the plasma metabolome. Nature Communications. 7: 12360. PMID 27453504 DOI: 10.1038/ncomms12360  0.32
2016 Charng WL, Karaca E, Coban Akdemir Z, Gambin T, Atik MM, Gu S, Posey JE, Jhangiani SN, Muzny DM, Doddapaneni H, Hu J, Boerwinkle E, Gibbs RA, Rosenfeld JA, Cui H, et al. Exome sequencing in mostly consanguineous Arab families with neurologic disease provides a high potential molecular diagnosis rate. Bmc Medical Genomics. 9: 42. PMID 27435318 DOI: 10.1186/s12920-016-0208-3  0.32
2016 Li D, Misialek JR, Boerwinkle E, Gottesman RF, Sharrett AR, Mosley TH, Coresh J, Wruck LM, Knopman DS, Alonso A. Plasma phospholipids and prevalence of mild cognitive impairment and/or dementia in the ARIC Neurocognitive Study (ARIC-NCS). Alzheimer's & Dementia (Amsterdam, Netherlands). 3: 73-82. PMID 27408938 DOI: 10.1016/j.dadm.2016.02.008  0.32
2016 Shahin MH, Gong Y, McDonough CW, Rotroff DM, Beitelshees AL, Garrett TJ, Gums JG, Motsinger-Reif A, Chapman AB, Turner ST, Boerwinkle E, Frye RF, Fiehn O, Cooper-DeHoff RM, Kaddurah-Daouk R, et al. A Genetic Response Score for Hydrochlorothiazide Use: Insights From Genomics and Metabolomics Integration. Hypertension. PMID 27381900 DOI: 10.1161/HYPERTENSIONAHA.116.07328  0.32
2016 Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T, Fall T, Kilpeläinen TO, Lu Y, Mägi R, Mihailov E, Pers TH, Rüeger S, ... ... Boerwinkle E, et al. Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. Plos Genetics. 12: e1006166. PMID 27355579 DOI: 10.1371/journal.pgen.1006166  0.32
2016 Tajuddin SM, Schick UM, Eicher JD, Chami N, Giri A, Brody JA, Hill WD, Kacprowski T, Li J, Lyytikäinen LP, Manichaikul A, Mihailov E, O'Donoghue ML, Pankratz N, Pazoki R, ... ... Boerwinkle E, et al. Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases. American Journal of Human Genetics. PMID 27346689 DOI: 10.1016/j.ajhg.2016.05.003  0.44
2016 Eicher JD, Chami N, Kacprowski T, Nomura A, Chen MH, Yanek LR, Tajuddin SM, Schick UM, Slater AJ, Pankratz N, Polfus L, Schurmann C, Giri A, Brody JA, Lange LA, ... ... Boerwinkle E, et al. Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals. American Journal of Human Genetics. PMID 27346686 DOI: 10.1016/j.ajhg.2016.05.005  0.44
2016 Chami N, Chen MH, Slater AJ, Eicher JD, Evangelou E, Tajuddin SM, Love-Gregory L, Kacprowski T, Schick UM, Nomura A, Giri A, Lessard S, Brody JA, Schurmann C, Pankratz N, ... ... Boerwinkle E, et al. Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits. American Journal of Human Genetics. PMID 27346685 DOI: 10.1016/j.ajhg.2016.05.007  0.44
2016 Yazdani A, Yazdani A, Saniei A, Boerwinkle E. A causal network analysis in an observational study identifies metabolomics pathways influencing plasma triglyceride levels. Metabolomics : Official Journal of the Metabolomic Society. 12: 104. PMID 27330524 DOI: 10.1007/s11306-016-1045-2  0.32
2016 Liu CT, Raghavan S, Maruthur N, Kabagambe EK, Hong J, Ng MC, Hivert MF, Lu Y, An P, Bentley AR, Drolet AM, Gaulton KJ, Guo X, Armstrong LL, Irvin MR, ... ... Boerwinkle E, et al. Trans-ethnic Meta-Analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin. American Journal of Human Genetics. PMID 27321945 DOI: 10.1016/j.ajhg.2016.05.006  0.32
2016 Kapoor A, Bakshy K, Xu L, Nandakumar P, Lee D, Boerwinkle E, Grove ML, Arking DE, Chakravarti A. Rare coding TTN variants are associated with electrocardiographic QT interval in the general population. Scientific Reports. 6: 28356. PMID 27321809 DOI: 10.1038/srep28356  0.32
2016 Scott RA, Freitag DF, Li L, Chu AY, Surendran P, Young R, Grarup N, Stancáková A, Chen Y, Varga TV, Yaghootkar H, Luan J, Zhao JH, Willems SM, Wessel J, ... ... Boerwinkle E, et al. A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease. Science Translational Medicine. 8: 341ra76. PMID 27252175 DOI: 10.1126/scitranslmed.aad3744  0.32
2016 Sung YJ, Winkler TW, Manning AK, Aschard H, Gudnason V, Harris TB, Smith AV, Boerwinkle E, Brown MR, Morrison AC, Fornage M, Lin LA, Richard M, Bartz TM, Psaty BM, et al. An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group. Genetic Epidemiology. PMID 27230302 DOI: 10.1002/gepi.21978  0.84
2016 Allen NB, Lloyd-Jones D, Hwang SJ, Rasmussen-Torvik L, Fornage M, Morrison AC, Baldridge AS, Boerwinkle E, Levy D, Cupples LA, Fox CS, Thanassoulis G, Dufresne L, Daviglus M, Johnson AD, et al. Genetic loci associated with ideal cardiovascular health: A meta-analysis of genome-wide association studies. American Heart Journal. 175: 112-20. PMID 27179730 DOI: 10.1016/j.ahj.2015.12.022  0.84
2016 Mirzaa GM, Campbell CD, Solovieff N, Goold CP, Jansen LA, Menon S, Timms AE, Conti V, Biag JD, Olds C, Boyle EA, Collins S, Ishak G, Poliachik SL, Girisha KM, ... ... Boerwinkle E, et al. Association of MTOR Mutations With Developmental Brain Disorders, Including Megalencephaly, Focal Cortical Dysplasia, and Pigmentary Mosaicism. Jama Neurology. PMID 27159400 DOI: 10.1001/jamaneurol.2016.0363  0.32
2016 Smith JG, Felix JF, Morrison AC, Kalogeropoulos A, Trompet S, Wilk JB, Gidlöf O, Wang X, Morley M, Mendelson M, Joehanes R, Ligthart S, Shan X, Bis JC, Wang YA, ... ... Boerwinkle E, et al. Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure. Plos Genetics. 12: e1006034. PMID 27149122 DOI: 10.1371/journal.pgen.1006034  0.32
2016 Khera AV, Won HH, Peloso GM, Lawson KS, Bartz TM, Deng X, van Leeuwen EM, Natarajan P, Emdin CA, Bick AG, Morrison AC, Brody JA, Gupta N, Nomura A, Kessler T, ... ... Boerwinkle E, et al. Diagnostic Yield of Sequencing Familial Hypercholesterolemia Genes in Patients with Severe Hypercholesterolemia. Journal of the American College of Cardiology. PMID 27050191 DOI: 10.1016/j.jacc.2016.03.520  0.32
2016 van Leeuwen EM, Sabo A, Bis JC, Huffman JE, Manichaikul A, Smith AV, Feitosa MF, Demissie S, Joshi PK, Duan Q, Marten J, van Klinken JB, Surakka I, Nolte IM, Zhang W, ... ... Boerwinkle E, et al. Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels. Journal of Medical Genetics. PMID 27036123 DOI: 10.1136/jmedgenet-2015-103439  0.32
2016 Dehghan A, Bis JC, White CC, Smith AV, Morrison AC, Cupples LA, Trompet S, Chasman DI, Lumley T, Völker U, Buckley BM, Ding J, Jensen MK, Folsom AR, Kritchevsky SB, ... ... Boerwinkle E, et al. Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium. Plos One. 11: e0144997. PMID 26950853 DOI: 10.1371/journal.pone.0144997  0.84
2016 Harel T, Yesil G, Bayram Y, Coban-Akdemir Z, Charng WL, Karaca E, Al Asmari A, Eldomery MK, Hunter JV, Jhangiani SN, Rosenfeld JA, Pehlivan D, El-Hattab AW, Saleh MA, LeDuc CA, ... ... Boerwinkle E, et al. Monoallelic and Biallelic Variants in EMC1 Identified in Individuals with Global Developmental Delay, Hypotonia, Scoliosis, and Cerebellar Atrophy. American Journal of Human Genetics. 98: 562-570. PMID 26942288 DOI: 10.1016/j.ajhg.2016.01.011  0.32
2016 Gomez-Ospina N, Potter CJ, Xiao R, Manickam K, Kim MS, Kim KH, Shneider BL, Picarsic JL, Jacobson TA, Zhang J, He W, Liu P, Knisely AS, Finegold MJ, Muzny DM, ... Boerwinkle E, et al. Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis. Nature Communications. 7: 10713. PMID 26888176 DOI: 10.1038/ncomms10713  0.32
2016 Ogunwale AN, Morrison AC, Sun W, Dodge RC, Virani SS, Taylor A, Gottesman RF, Yang E, Wei P, McEvoy JW, Heiss G, Boerwinkle E, Ballantyne CM, Nambi V. The impact of multiple single day blood pressure readings on cardiovascular risk estimation: The Atherosclerosis Risk in Communities study. European Journal of Preventive Cardiology. PMID 26869459 DOI: 10.1177/2047487316633549  0.32
2016 Willems SM, Cornes BK, Brody JA, Morrison AC, Lipovich L, Dauriz M, Chen Y, Liu CT, Rybin DV, Gibbs RA, Muzny D, Pankow JS, Psaty BM, Boerwinkle E, Rotter JI, et al. Association of the IGF1 gene with fasting insulin levels. European Journal of Human Genetics : Ejhg. PMID 26860063 DOI: 10.1038/ejhg.2016.4  0.32
2016 Vu KN, Ballantyne CM, Hoogeveen RC, Nambi V, Volcik KA, Boerwinkle E, Morrison AC. Causal Role of Alcohol Consumption in an Improved Lipid Profile: The Atherosclerosis Risk in Communities (ARIC) Study. Plos One. 11: e0148765. PMID 26849558 DOI: 10.1371/journal.pone.0148765  0.32
2016 Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V, Garnaas M, Tin A, Sorice R, Li Y, Taliun D, Olden M, Foster M, Yang Q, Chen MH, ... ... Boerwinkle E, et al. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nature Communications. 7: 10023. PMID 26831199 DOI: 10.1038/ncomms10023  0.32
2016 Yazdani A, Yazdani A, Samiei A, Boerwinkle E. Generating a robust statistical causal structure over 13 cardiovascular disease risk factors using genomics data. Journal of Biomedical Informatics. PMID 26827624 DOI: 10.1016/j.jbi.2016.01.012  0.32
2016 Lalani SR, Liu P, Rosenfeld JA, Watkin LB, Chiang T, Leduc MS, Zhu W, Ding Y, Pan S, Vetrini F, Miyake CY, Shinawi M, Gambin T, Eldomery MK, Akdemir ZH, ... ... Boerwinkle E, et al. Recurrent Muscle Weakness with Rhabdomyolysis, Metabolic Crises, and Cardiac Arrhythmia due to Bi-allelic TANGO2 Mutations. American Journal of Human Genetics. PMID 26805781 DOI: 10.1016/j.ajhg.2015.12.008  0.32
2016 Bayram Y, Karaca E, Coban Akdemir Z, Yilmaz EO, Tayfun GA, Aydin H, Torun D, Bozdogan ST, Gezdirici A, Isikay S, Atik MM, Gambin T, Harel T, El-Hattab AW, Charng WL, ... ... Boerwinkle E, et al. Molecular etiology of arthrogryposis in multiple families of mostly Turkish origin. The Journal of Clinical Investigation. PMID 26752647 DOI: 10.1172/JCI84457  0.32
2016 White J, Beck CR, Harel T, Posey JE, Jhangiani SN, Tang S, Farwell KD, Powis Z, Mendelsohn NJ, Baker JA, Pollack L, Mason KJ, Wierenga KJ, Arrington DK, Hall M, ... ... Boerwinkle E, et al. POGZ truncating alleles cause syndromic intellectual disability. Genome Medicine. 8: 3. PMID 26739615 DOI: 10.1186/s13073-015-0253-0  0.32
2016 Gong Y, Wang Z, Beitelshees AL, McDonough CW, Langaee TY, Hall K, Schmidt SO, Curry RW, Gums JG, Bailey KR, Boerwinkle E, Chapman AB, Turner ST, Cooper-DeHoff RM, Johnson JA. Pharmacogenomic Genome-Wide Meta-Analysis of Blood Pressure Response to β-Blockers in Hypertensive African Americans. Hypertension. PMID 26729753 DOI: 10.1161/HYPERTENSIONAHA.115.06345  0.32
2016 Do AN, Lynch AI, Claas SA, Boerwinkle E, Davis BR, Ford CE, Eckfeldt JH, Tiwari HK, Arnett DK, Irvin MR. The effects of genes implicated in cardiovascular disease on blood pressure response to treatment among treatment-naive hypertensive African Americans in the GenHAT study Journal of Human Hypertension. DOI: 10.1038/jhh.2015.121  0.32
2016 Allen NB, Lloyd-Jones D, Hwang SJ, Rasmussen-Torvik L, Fornage M, Morrison AC, Baldridge AS, Boerwinkle E, Levy D, Cupples LA, Fox CS, Thanassoulis G, Dufresne L, Daviglus M, Johnson AD, et al. Genetic loci associated with ideal cardiovascular health: A meta-analysis of genome-wide association studies American Heart Journal. 175: 112-120. DOI: 10.1016/j.ahj.2015.12.022  0.32
2015 van Leeuwen EM, Huffman JE, Bis JC, Isaacs A, Mulder M, Sabo A, Smith AV, Demissie S, Manichaikul A, Brody JA, Feitosa MF, Duan Q, Schraut KE, Navarro P, van Vliet-Ostaptchouk JV, ... ... Boerwinkle E, et al. Fine mapping the CETP region reveals a common intronic insertion associated to HDL-C. Npj Aging and Mechanisms of Disease. 1: 15011. PMID 28721259 DOI: 10.1038/npjamd.2015.11  0.84
2015 Lunetta KL, Day FR, Sulem P, Ruth KS, Tung JY, Hinds DA, Esko T, Elks CE, Altmaier E, He C, Huffman JE, Mihailov E, Porcu E, Robino A, Rose LM, ... ... Boerwinkle E, et al. Corrigendum: Rare coding variants and X-linked loci associated with age at menarche. Nature Communications. 6: 10257. PMID 26674845 DOI: 10.1038/ncomms10257  0.32
2015 Campbell IM, Gambin T, Jhanghiani S, Grove ML, Veeraraghavan N, Muzny D, Shaw CA, Gibbs RA, Boerwinkle E, Yu F, Lupski JR. Multiallelic Positions in the Human Genome: Challenges for Genetic Analyses. Human Mutation. PMID 26670213 DOI: 10.1002/humu.22944  0.32
2015 Yu B, Pulit SL, Hwang SJ, Brody JA, Amin N, Auer PL, Bis JC, Boerwinkle E, Burke GL, Chakravarti A, Correa A, Dreisbach AW, Franco OH, Ehret GB, Franceschini N, et al. Rare Exome Sequence Variants in CLCN6 Reduce Blood Pressure Levels and Hypertension Risk. Circulation. Cardiovascular Genetics. PMID 26658788 DOI: 10.1161/CIRCGENETICS.115.001215  0.32
2015 Yazdani A, Yazdani A, Boerwinkle E. Rare variants analysis using penalization methods for whole genome sequence data. Bmc Bioinformatics. 16: 405. PMID 26637205 DOI: 10.1186/s12859-015-0825-4  0.32
2015 Posey JE, Rosenfeld JA, James RA, Bainbridge M, Niu Z, Wang X, Dhar S, Wiszniewski W, Akdemir ZH, Gambin T, Xia F, Person RE, Walkiewicz M, Shaw CA, Sutton VR, ... ... Boerwinkle E, et al. Molecular diagnostic experience of whole-exome sequencing in adult patients. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 26633545 DOI: 10.1038/gim.2015.142  0.32
2015 Teumer A, Tin A, Sorice R, Gorski M, Yeo NC, Chu AY, Li M, Li Y, Mijatovic V, Ko YA, Taliun D, Luciani A, Chen MH, Yang Q, Foster MC, ... ... Boerwinkle E, et al. Genome-wide Association Studies Identify Genetic Loci Associated with Albuminuria in Diabetes. Diabetes. PMID 26631737 DOI: 10.2337/db15-1313  0.32
2015 Farlow JL, Robak LA, Hetrick K, Bowling K, Boerwinkle E, Coban-Akdemir ZH, Gambin T, Gibbs RA, Gu S, Jain P, Jankovic J, Jhangiani S, Kaw K, Lai D, Lin H, et al. Whole-Exome Sequencing in Familial Parkinson Disease. Jama Neurology. 1-8. PMID 26595808 DOI: 10.1001/jamaneurol.2015.3266  0.32
2015 Jensen RA, Sim X, Smith AV, Li X, Jakobsdóttir J, Cheng CY, Brody JA, Cotch MF, McKnight B, Klein R, Wang JJ, Kifley A, Harris TB, Launer LJ, Taylor KD, ... ... Boerwinkle E, et al. Novel Genetic Loci Associated with Retinal Microvascular Diameter. Circulation. Cardiovascular Genetics. PMID 26567291 DOI: 10.1161/CIRCGENETICS.115.001142  0.32
2015 Liu X, Wu C, Li C, Boerwinkle E. dbNSFP v3.0: A One-Stop Database of Functional Predictions and Annotations for Human Non-synonymous and Splice Site SNVs. Human Mutation. PMID 26555599 DOI: 10.1002/humu.22932  0.32
2015 Alonso A, Yu B, Qureshi WT, Grams ME, Selvin E, Soliman EZ, Loehr LR, Chen LY, Agarwal SK, Alexander D, Boerwinkle E. Metabolomics and Incidence of Atrial Fibrillation in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study. Plos One. 10: e0142610. PMID 26544570 DOI: 10.1371/journal.pone.0142610  0.32
2015 Karaca E, Harel T, Pehlivan D, Jhangiani SN, Gambin T, Coban Akdemir Z, Gonzaga-Jauregui C, Erdin S, Bayram Y, Campbell IM, Hunter JV, Atik MM, Van Esch H, Yuan B, Wiszniewski W, ... ... Boerwinkle E, et al. Genes that Affect Brain Structure and Function Identified by Rare Variant Analyses of Mendelian Neurologic Disease. Neuron. 88: 499-513. PMID 26539891 DOI: 10.1016/j.neuron.2015.09.048  0.32
2015 Bis JC, Sitlani C, Irvin R, Avery CL, Smith AV, Sun F, Evans DS, Musani SK, Li X, Trompet S, Krijthe BP, Harris TB, Quibrera PM, Brody JA, Demissie S, ... ... Boerwinkle E, et al. Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium. Plos One. 10: e0140496. PMID 26516778 DOI: 10.1371/journal.pone.0140496  0.32
2015 Barral S, Cheng R, Reitz C, Vardarajan B, Lee J, Kunkle B, Beecham G, Cantwell LS, Pericak-Vance MA, Farrer LA, Haines JL, Goate AM, Foroud T, Boerwinkle E, Schellenberg GD, et al. Linkage analyses in Caribbean Hispanic families identify novel loci associated with familial late-onset Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26433351 DOI: 10.1016/j.jalz.2015.07.487  0.32
2015 Tin A, Balakrishnan P, Beaty TH, Boerwinkle E, Hoogeveen RC, Young JH, Kao WH. GCKR and PPP1R3B identified as genome-wide significant loci for plasma lactate: the Atherosclerosis Risk in Communities (ARIC) study. Diabetic Medicine : a Journal of the British Diabetic Association. PMID 26433129 DOI: 10.1111/dme.12971  0.32
2015 Gong Y, McDonough CW, Beitelshees AL, Rouby NE, Hiltunen TP, O'Connell JR, Padmanabhan S, Langaee TY, Hall K, Schmidt SO, Curry RW, Gums JG, Donner KM, Kontula KK, Bailey KR, ... Boerwinkle E, et al. PTPRD gene associated with blood pressure response to atenolol and resistant hypertension. Journal of Hypertension. 33: 2278-85. PMID 26425837 DOI: 10.1097/HJH.0000000000000714  0.32
2015 Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI, Stolk L, Finucane HK, Sulem P, Bulik-Sullivan B, Esko T, Johnson AD, Elks CE, Franceschini N, He C, ... ... Boerwinkle E, et al. Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nature Genetics. PMID 26414677 DOI: 10.1038/ng.3412  0.84
2015 Liu X, White S, Peng B, Johnson AD, Brody JA, Li AH, Huang Z, Carroll A, Wei P, Gibbs R, Klein RJ, Boerwinkle E. WGSA: an annotation pipeline for human genome sequencing studies. Journal of Medical Genetics. PMID 26395054 DOI: 10.1136/jmedgenet-2015-103423  0.32
2015 Tao R, Zeng D, Franceschini N, North KE, Boerwinkle E, Lin DY. Analysis of Sequence Data Under Multivariate Trait-Dependent Sampling. Journal of the American Statistical Association. 110: 560-572. PMID 26366025 DOI: 10.1080/01621459.2015.1008099  0.32
2015 Nikpay M, Goel A, Won HH, Hall LM, Willenborg C, Kanoni S, Saleheen D, Kyriakou T, Nelson CP, Hopewell JC, Webb TR, Zeng L, Dehghan A, Alver M, Armasu SM, ... ... Boerwinkle E, et al. A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nature Genetics. 47: 1121-30. PMID 26343387 DOI: 10.1038/ng.3396  0.84
2015 Song J, Chen F, Campos M, Bolgiano D, Houck K, Chambless LE, Wu KK, Folsom AR, Couper D, Boerwinkle E, Dong JF. Quantitative Influence of ABO Blood Groups on Factor VIII and Its Ratio to von Willebrand Factor, Novel Observations from an ARIC Study of 11,673 Subjects. Plos One. 10: e0132626. PMID 26244499 DOI: 10.1371/journal.pone.0132626  0.32
2015 Scantlebury DC, Kane GC, Wiste HJ, Bailey KR, Turner ST, Arnett DK, Devereux RB, Mosley TH, Hunt SC, Weder AB, Rodriguez B, Boerwinkle E, Weissgerber TL, Garovic VD. Left ventricular hypertrophy after hypertensive pregnancy disorders. Heart (British Cardiac Society). 101: 1584-90. PMID 26243788 DOI: 10.1136/heartjnl-2015-308098  0.32
2015 Lunetta KL, Day FR, Sulem P, Ruth KS, Tung JY, Hinds DA, Esko T, Elks CE, Altmaier E, He C, Huffman JE, Mihailov E, Porcu E, Robino A, Rose LM, ... ... Boerwinkle E, et al. Rare coding variants and X-linked loci associated with age at menarche. Nature Communications. 6: 7756. PMID 26239645 DOI: 10.1038/ncomms8756  0.32
2015 Bressler J, Franceschini N, Demerath EW, Mosley TH, Folsom AR, Boerwinkle E. Sequence variation in telomerase reverse transcriptase (TERT) as a determinant of risk of cardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) study. Bmc Medical Genetics. 16: 52. PMID 26201603 DOI: 10.1186/s12881-015-0194-x  0.32
2015 Gambin T, Jhangiani SN, Below JE, Campbell IM, Wiszniewski W, Muzny DM, Staples J, Morrison AC, Bainbridge MN, Penney S, McGuire AL, Gibbs RA, Lupski JR, Boerwinkle E. Secondary findings and carrier test frequencies in a large multiethnic sample. Genome Medicine. 7: 54. PMID 26195989 DOI: 10.1186/s13073-015-0171-1  0.84
2015 Chong JX, Buckingham KJ, Jhangiani SN, Boehm C, Sobreira N, Smith JD, Harrell TM, McMillin MJ, Wiszniewski W, Gambin T, Coban Akdemir ZH, Doheny K, Scott AF, Avramopoulos D, Chakravarti A, ... ... Boerwinkle E, et al. The Genetic Basis of Mendelian Phenotypes: Discoveries, Challenges, and Opportunities. American Journal of Human Genetics. 97: 199-215. PMID 26166479 DOI: 10.1016/j.ajhg.2015.06.009  0.32
2015 Salfati E, Morrison AC, Boerwinkle E, Chakravarti A. Direct Estimates of the Genomic Contributions to Blood Pressure Heritability within a Population-Based Cohort (ARIC). Plos One. 10: e0133031. PMID 26162070 DOI: 10.1371/journal.pone.0133031  0.32
2015 Pokharel Y, Sun W, Polfus LM, Folsom AR, Heiss G, Sharrett AR, Boerwinkle E, Ballantyne CM, Hoogeveen RC. Lipoprotein associated phospholipase A2 activity, apolipoprotein C3 loss-of-function variants and cardiovascular disease: The Atherosclerosis Risk In Communities Study. Atherosclerosis. 241: 641-8. PMID 26117401 DOI: 10.1016/j.atherosclerosis.2015.06.033  0.32
2015 Aslibekyan S, Demerath EW, Mendelson M, Zhi D, Guan W, Liang L, Sha J, Pankow JS, Liu C, Irvin MR, Fornage M, Hidalgo B, Lin LA, Stanton Thibeault K, Bressler J, ... ... Boerwinkle E, et al. Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference. Obesity (Silver Spring, Md.). 23: 1493-1501. PMID 26110892 DOI: 10.1002/oby.21111  0.32
2015 Huffman JE, de Vries PS, Morrison AC, Sabater-Lleal M, Kacprowski T, Auer PL, Brody JA, Chasman DI, Chen MH, Guo X, Lin LA, Marioni RE, Müller-Nurasyid M, Yanek LR, Pankratz N, ... ... Boerwinkle E, et al. Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF. Blood. 126: e19-29. PMID 26105150 DOI: 10.1182/blood-2015-02-624551  0.32
2015 Maruthur NM, Li M, Halushka MK, Astor BC, Pankow JS, Boerwinkle E, Coresh J, Selvin E, Kao WH. Genetics of Plasma Soluble Receptor for Advanced Glycation End-Products and Cardiovascular Outcomes in a Community-based Population: Results from the Atherosclerosis Risk in Communities Study. Plos One. 10: e0128452. PMID 26083729 DOI: 10.1371/journal.pone.0128452  0.32
2015 Jansen H, Loley C, Lieb W, Pencina MJ, Nelson CP, Kathiresan S, Peloso GM, Voight BF, Reilly MP, Assimes TL, Boerwinkle E, Hengstenberg C, Laaksonen R, McPherson R, Roberts R, et al. Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk. Atherosclerosis. 241: 419-26. PMID 26074316 DOI: 10.1016/j.atherosclerosis.2015.05.033  0.32
2015 Tin A, Köttgen A, Folsom AR, Maruthur NM, Tajuddin SM, Nalls MA, Evans MK, Zonderman AB, Friedrich CA, Boerwinkle E, Coresh J, Kao WH. Genetic loci for serum magnesium among African-Americans and gene-environment interaction at MUC1 and TRPM6 in European-Americans: the Atherosclerosis Risk in Communities (ARIC) study. Bmc Genetics. 16: 56. PMID 26058915 DOI: 10.1186/s12863-015-0219-7  0.32
2015 Shungin D, Cornelis MC, Divaris K, Holtfreter B, Shaffer JR, Yu YH, Barros SP, Beck JD, Biffar R, Boerwinkle EA, Crout RJ, Ganna A, Hallmans G, Hindy G, Hu FB, et al. Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium. International Journal of Epidemiology. 44: 638-50. PMID 26050256 DOI: 10.1093/ije/dyv075  0.32
2015 Bainbridge MN, Davis EE, Choi WY, Dickson A, Martinez HR, Wang M, Dinh H, Muzny D, Pignatelli R, Katsanis N, Boerwinkle E, Gibbs R, Jefferies JL. Loss of Function Mutations in NNT Are Associated with Left Ventricular Noncompaction. Circulation. Cardiovascular Genetics. PMID 26025024 DOI: 10.1161/CIRCGENETICS.115.001026  0.32
2015 Rahbar MH, Samms-Vaughan M, Dickerson AS, Hessabi M, Bressler J, Desai CC, Shakespeare-Pellington S, Reece JA, Morgan R, Loveland KA, Grove ML, Boerwinkle E. Concentration of lead, mercury, cadmium, aluminum, arsenic and manganese in umbilical cord blood of Jamaican newborns. International Journal of Environmental Research and Public Health. 12: 4481-501. PMID 25915835 DOI: 10.3390/ijerph120504481  0.32
2015 Li AH, Morrison AC, Kovar C, Cupples LA, Brody JA, Polfus LM, Yu B, Metcalf G, Muzny D, Veeraraghavan N, Liu X, Lumley T, Mosley TH, Gibbs RA, Boerwinkle E. Analysis of loss-of-function variants and 20 risk factor phenotypes in 8,554 individuals identifies loci influencing chronic disease. Nature Genetics. 47: 640-2. PMID 25915599 DOI: 10.1038/ng.3270  0.32
2015 Watkin LB, Jessen B, Wiszniewski W, Vece TJ, Jan M, Sha Y, Thamsen M, Santos-Cortez RL, Lee K, Gambin T, Forbes LR, Law CS, Stray-Pedersen A, Cheng MH, Mace EM, ... ... Boerwinkle E, et al. COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis. Nature Genetics. 47: 654-60. PMID 25894502 DOI: 10.1038/ng.3279  0.32
2015 Wang M, Beck CR, English AC, Meng Q, Buhay C, Han Y, Doddapaneni HV, Yu F, Boerwinkle E, Lupski JR, Muzny DM, Gibbs RA. PacBio-LITS: a large-insert targeted sequencing method for characterization of human disease-associated chromosomal structural variations. Bmc Genomics. 16: 214. PMID 25887218 DOI: 10.1186/s12864-015-1370-2  0.32
2015 English AC, Salerno WJ, Hampton OA, Gonzaga-Jauregui C, Ambreth S, Ritter DI, Beck CR, Davis CF, Dahdouli M, Ma S, Carroll A, Veeraraghavan N, Bruestle J, Drees B, Hastie A, ... ... Boerwinkle E, et al. Assessing structural variation in a personal genome-towards a human reference diploid genome. Bmc Genomics. 16: 286. PMID 25886820 DOI: 10.1186/s12864-015-1479-3  0.32
2015 Rahbar MH, Samms-Vaughan M, Dickerson AS, Loveland KA, Ardjomand-Hessabi M, Bressler J, Shakespeare-Pellington S, Grove ML, Boerwinkle E. Factors associated with blood lead concentrations of children in Jamaica. Journal of Environmental Science and Health. Part a, Toxic/Hazardous Substances & Environmental Engineering. 50: 529-39. PMID 25837555 DOI: 10.1080/10934529.2015.994932  0.32
2015 van der Lee SJ, Holstege H, Wong TH, Jakobsdottir J, Bis JC, Chouraki V, van Rooij JG, Grove ML, Smith AV, Amin N, Choi SH, Beiser AS, Garcia ME, van IJcken WF, Pijnenburg YA, ... ... Boerwinkle E, et al. PLD3 variants in population studies. Nature. 520: E2-3. PMID 25832410 DOI: 10.1038/nature14038  0.32
2015 Yu F, Lu J, Liu X, Gazave E, Chang D, Raj S, Hunter-Zinck H, Blekhman R, Arbiza L, Van Hout C, Morrison A, Johnson AD, Bis J, Cupples LA, Psaty BM, ... ... Boerwinkle E, et al. Population genomic analysis of 962 whole genome sequences of humans reveals natural selection in non-coding regions. Plos One. 10: e0121644. PMID 25807536 DOI: 10.1371/journal.pone.0121644  0.32
2015 Bayram Y, Gulsuner S, Guran T, Abaci A, Yesil G, Gulsuner HU, Atay Z, Pierce SB, Gambin T, Lee M, Turan S, Bober E, Atik MM, Walsh T, Karaca E, ... ... Boerwinkle E, et al. Homozygous loss-of-function mutations in SOHLH1 in patients with nonsyndromic hypergonadotropic hypogonadism. The Journal of Clinical Endocrinology and Metabolism. 100: E808-14. PMID 25774885 DOI: 10.1210/jc.2015-1150  0.32
2015 Ligthart S, de Vries PS, Uitterlinden AG, Hofman A, Franco OH, Chasman DI, Dehghan A. Pleiotropy among common genetic loci identified for cardiometabolic disorders and C-reactive protein. Plos One. 10: e0118859. PMID 25768928 DOI: 10.1371/journal.pone.0118859  0.32
2015 Roger VL, Boerwinkle E, Crapo JD, Douglas PS, Epstein JA, Granger CB, Greenland P, Kohane I, Psaty BM. Strategic transformation of population studies: recommendations of the working group on epidemiology and population sciences from the National Heart, Lung, and Blood Advisory Council and Board of External Experts. American Journal of Epidemiology. 181: 363-8. PMID 25743324 DOI: 10.1093/aje/kwv011  0.32
2015 Roger VL, Boerwinkle E, Crapo JD, Douglas PS, Epstein JA, Granger CB, Greenland P, Kohane I, Psaty BM. Roger et al. respond to "future of population studies". American Journal of Epidemiology. 181: 372-3. PMID 25743323 DOI: 10.1093/aje/kwv009  0.32
2015 Beck TF, Campeau PM, Jhangiani SN, Gambin T, Li AH, Abo-Zahrah R, Jordan VK, Hernandez-Garcia A, Wiszniewski WK, Muzny D, Gibbs RA, Boerwinkle E, Lupski JR, Lee B, Reardon W, et al. FBN1 contributing to familial congenital diaphragmatic hernia. American Journal of Medical Genetics. Part A. 167: 831-6. PMID 25736269 DOI: 10.1002/ajmg.a.36960  0.32
2015 Chittani M, Zaninello R, Lanzani C, Frau F, Ortu MF, Salvi E, Fresu G, Citterio L, Braga D, Piras DA, Carpini SD, Velayutham D, Simonini M, Argiolas G, Pozzoli S, ... ... Boerwinkle E, et al. TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives. Journal of Hypertension. 33: 1301-9. PMID 25695618 DOI: 10.1097/HJH.0000000000000541  0.32
2015 Verhaaren BF, Debette S, Bis JC, Smith JA, Ikram MK, Adams HH, Beecham AH, Rajan KB, Lopez LM, Barral S, van Buchem MA, van der Grond J, Smith AV, Hegenscheid K, Aggarwal NT, ... ... Boerwinkle E, et al. Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI. Circulation. Cardiovascular Genetics. 8: 398-409. PMID 25663218 DOI: 10.1161/CIRCGENETICS.114.000858  0.32
2015 Debette S, Ibrahim Verbaas CA, Bressler J, Schuur M, Smith A, Bis JC, Davies G, Wolf C, Gudnason V, Chibnik LB, Yang Q, deStefano AL, de Quervain DJ, Srikanth V, Lahti J, ... ... Boerwinkle E, et al. Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. Biological Psychiatry. 77: 749-63. PMID 25648963 DOI: 10.1016/j.biopsych.2014.08.027  0.32
2015 Davies G, Armstrong N, Bis JC, Bressler J, Chouraki V, Giddaluru S, Hofer E, Ibrahim-Verbaas CA, Kirin M, Lahti J, van der Lee SJ, Le Hellard S, Liu T, Marioni RE, Oldmeadow C, ... ... Boerwinkle E, et al. Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949). Molecular Psychiatry. 20: 183-92. PMID 25644384 DOI: 10.1038/mp.2014.188  0.32
2015 Wessel J, Chu AY, Willems SM, Wang S, Yaghootkar H, Brody JA, Dauriz M, Hivert MF, Raghavan S, Lipovich L, Hidalgo B, Fox K, Huffman JE, An P, Lu Y, ... ... Boerwinkle E, et al. Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. Nature Communications. 6: 5897. PMID 25631608 DOI: 10.1038/ncomms6897  0.84
2015 Hiltunen TP, Donner KM, Sarin AP, Saarela J, Ripatti S, Chapman AB, Gums JG, Gong Y, Cooper-DeHoff RM, Frau F, Glorioso V, Zaninello R, Salvi E, Glorioso N, Boerwinkle E, et al. Pharmacogenomics of hypertension: a genome‐wide, placebo‐controlled cross‐over study, using four classes of antihypertensive drugs. Journal of the American Heart Association. 4: e001521. PMID 25622599 DOI: 10.1161/JAHA.115.001778  0.32
2015 Holliday EG, Traylor M, Malik R, Bevan S, Falcone G, Hopewell JC, Cheng YC, Cotlarciuc I, Bis JC, Boerwinkle E, Boncoraglio GB, Clarke R, Cole JW, Fornage M, Furie KL, et al. Genetic overlap between diagnostic subtypes of ischemic stroke. Stroke; a Journal of Cerebral Circulation. 46: 615-9. PMID 25613305 DOI: 10.1161/STROKEAHA.114.007930  0.32
2015 Polfus LM, Gibbs RA, Boerwinkle E. Coronary heart disease and genetic variants with low phospholipase A2 activity. The New England Journal of Medicine. 372: 295-6. PMID 25587968 DOI: 10.1056/NEJMc1409673  0.32
2015 Yu B, Li AH, Muzny D, Veeraraghavan N, de Vries PS, Bis JC, Musani SK, Alexander D, Morrison AC, Franco OH, Uitterlinden A, Hofman A, Dehghan A, Wilson JG, Psaty BM, ... ... Boerwinkle E, et al. Association of Rare Loss-Of-Function Alleles in HAL, Serum Histidine: Levels and Incident Coronary Heart Disease. Circulation. Cardiovascular Genetics. 8: 351-5. PMID 25575548 DOI: 10.1161/CIRCGENETICS.114.000697  0.32
2015 Weng LC, Cushman M, Pankow JS, Basu S, Boerwinkle E, Folsom AR, Tang W. A genetic association study of activated partial thromboplastin time in European Americans and African Americans: the ARIC Study. Human Molecular Genetics. 24: 2401-8. PMID 25552651 DOI: 10.1093/hmg/ddu732  0.32
2015 Dong C, Wei P, Jian X, Gibbs R, Boerwinkle E, Wang K, Liu X. Comparison and integration of deleteriousness prediction methods for nonsynonymous SNVs in whole exome sequencing studies. Human Molecular Genetics. 24: 2125-37. PMID 25552646 DOI: 10.1093/hmg/ddu733  0.32
2015 Shetty PB, Tang H, Feng T, Tayo B, Morrison AC, Kardia SL, Hanis CL, Arnett DK, Hunt SC, Boerwinkle E, Rao DC, Cooper RS, Risch N, Zhu X. Variants for HDL-C, LDL-C, and triglycerides identified from admixture mapping and fine-mapping analysis in African American families. Circulation. Cardiovascular Genetics. 8: 106-13. PMID 25552592 DOI: 10.1161/CIRCGENETICS.114.000481  0.32
2015 Quarta CC, Buxbaum JN, Shah AM, Falk RH, Claggett B, Kitzman DW, Mosley TH, Butler KR, Boerwinkle E, Solomon SD. The amyloidogenic V122I transthyretin variant in elderly black Americans. The New England Journal of Medicine. 372: 21-9. PMID 25551524 DOI: 10.1056/NEJMoa1404852  0.32
2015 Rahbar MH, Samms-Vaughan M, Dickerson AS, Loveland KA, Ardjomand-Hessabi M, Bressler J, Shakespeare-Pellington S, Grove ML, Pearson DA, Boerwinkle E. Blood lead concentrations in Jamaican children with and without autism spectrum disorder. International Journal of Environmental Research and Public Health. 12: 83-105. PMID 25546274 DOI: 10.3390/ijerph120100083  0.32
2015 Do R, Stitziel NO, Won HH, Jørgensen AB, Duga S, Angelica Merlini P, Kiezun A, Farrall M, Goel A, Zuk O, Guella I, Asselta R, Lange LA, Peloso GM, Auer PL, ... ... Boerwinkle E, et al. Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Nature. 518: 102-6. PMID 25487149 DOI: 10.1038/nature13917  0.32
2015 Ashar FN, Moes A, Moore AZ, Grove ML, Chaves PH, Coresh J, Newman AB, Matteini AM, Bandeen-Roche K, Boerwinkle E, Walston JD, Arking DE. Association of mitochondrial DNA levels with frailty and all-cause mortality. Journal of Molecular Medicine (Berlin, Germany). 93: 177-86. PMID 25471480 DOI: 10.1007/s00109-014-1233-3  0.32
2015 Riveiro-Álvarez R, Xie YA, López-Martínez MÁ, Gambin T, Pérez-Carro R, Ávila-Fernández A, López-Molina MI, Zernant J, Jhangiani S, Muzny D, Yuan B, Boerwinkle E, Gibbs R, Lupski JR, Ayuso C, et al. New mutations in the RAB28 gene in 2 Spanish families with cone-rod dystrophy. Jama Ophthalmology. 133: 133-9. PMID 25356532 DOI: 10.1001/jamaophthalmol.2014.4266  0.32
2015 Pokharel Y, Sun W, de Lemos JA, Taffet GE, Virani SS, Ndumele CE, Mosley TH, Hoogeveen RC, Coresh J, Wright JD, Heiss G, Boerwinkle EA, Bozkurt B, Solomon SD, Ballantyne CM, et al. High-sensitivity troponin T and cardiovascular events in systolic blood pressure categories: atherosclerosis risk in communities study. Hypertension. 65: 78-84. PMID 25350984 DOI: 10.1161/HYPERTENSIONAHA.114.04206  0.32
2015 Del-Aguila JL, Cooper-DeHoff RM, Chapman AB, Gums JG, Beitelshees AL, Bailey K, Turner ST, Johnson JA, Boerwinkle E. Transethnic meta-analysis suggests genetic variation in the HEME pathway influences potassium response in patients treated with hydrochlorothiazide. The Pharmacogenomics Journal. 15: 153-7. PMID 25201287 DOI: 10.1038/tpj.2014.46  0.32
2015 Schick UM, Auer PL, Bis JC, Lin H, Wei P, Pankratz N, Lange LA, Brody J, Stitziel NO, Kim DS, Carlson CS, Fornage M, Haessler J, Hsu L, Jackson RD, ... ... Boerwinkle E, et al. Association of exome sequences with plasma C-reactive protein levels in >9000 participants. Human Molecular Genetics. 24: 559-71. PMID 25187575 DOI: 10.1093/hmg/ddu450  0.32
2015 Zhao J, Zhu Y, Boerwinkle E, Xiong M. Pathway analysis with next-generation sequencing data. European Journal of Human Genetics : Ejhg. 23: 507-15. PMID 24986826 DOI: 10.1038/ejhg.2014.121  0.32
2015 Gupta-Malhotra M, Banker A, Shete S, Hashmi SS, Tyson JE, Barratt MS, Hecht JT, Milewicz DM, Boerwinkle E. Essential hypertension vs. secondary hypertension among children. American Journal of Hypertension. 28: 73-80. PMID 24842390 DOI: 10.1093/ajh/hpu083  0.32
2015 Gambin T, Jhangiani SN, Below JE, Campbell IM, Wiszniewski W, Muzny DM, Staples J, Morrison AC, Bainbridge MN, Penney S, McGuire AL, Gibbs RA, Lupski JR, Boerwinkle E. Secondary findings and carrier test frequencies in a large multiethnic sample Genome Medicine. 7. DOI: 10.1186/s13073-015-0171-1  0.32
2015 Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI, Stolk L, Finucane HK, Sulem P, Bulik-Sullivan B, Esko T, Johnson AD, Elks CE, Franceschini N, He C, ... ... Boerwinkle E, et al. Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair Obstetrical and Gynecological Survey. 70: 758-762. DOI: 10.1097/01.ogx.0000473766.71624.99  0.32
2015 Yang Y, Muzny DM, Xia F, Niu Z, Person R, Ding Y, Ward P, Braxton A, Wang M, Buhay C, Veeraraghavan N, Hawes A, Chiang T, Leduc M, Beuten J, ... ... Boerwinkle E, et al. Molecular findings among patients referred for clinical whole-exome sequencing: Editorial comment Obstetrical and Gynecological Survey. 70: 164-167. DOI: 10.1097/01.ogx.0000462915.64193.1b  0.32
2015 Auton A, Abecasis GR, Altshuler DM, Durbin RM, Bentley DR, Chakravarti A, Clark AG, Donnelly P, Eichler EE, Flicek P, Gabriel SB, Gibbs RA, Green ED, Hurles ME, Knoppers BM, ... ... Boerwinkle E, et al. A global reference for human genetic variation Nature. 526: 68-74. DOI: 10.1038/nature15393  0.32
2015 Rahbar MH, Samms-Vaughan M, Ma J, Bressler J, Dickerson AS, Hessabi M, Loveland KA, Grove ML, Shakespeare-Pellington S, Beecher C, McLaughlin W, Boerwinkle E. Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder Research in Autism Spectrum Disorders. 18: 73-82. DOI: 10.1016/j.rasd.2015.08.001  0.32
2015 Rahbar MH, Samms-Vaughan M, Ma J, Bressler J, Loveland KA, Hessabi M, Dickerson AS, Grove ML, Shakespeare-Pellington S, Beecher C, McLaughlin W, Boerwinkle E. Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders Research in Autism Spectrum Disorders. 12: 1-9. DOI: 10.1016/j.rasd.2014.12.008  0.32
2015 Chong JX, Buckingham KJ, Jhangiani SN, Boehm C, Sobreira N, Smith JD, Harrell TM, McMillin MJ, Wiszniewski W, Gambin T, CobanAkdemir ZH, Doheny K, Scott AF, Avramopoulos D, Chakravarti A, ... ... Boerwinkle E, et al. The Genetic Basis of Mendelian Phenotypes: Discoveries, Challenges, and Opportunities American Journal of Human Genetics. DOI: 10.1016/j.ajhg.2015.06.009  0.32
2014 Franceschini N, Hu Y, Reiner AP, Buyske S, Nalls M, Yanek LR, Li Y, Hindorff LA, Cole SA, Howard BV, Stafford JM, Carty CL, Sethupathy P, Martin LW, Lin DY, ... ... Boerwinkle E, et al. Prospective associations of coronary heart disease loci in African Americans using the MetaboChip: the PAGE study. Plos One. 9: e113203. PMID 25542012 DOI: 10.1371/journal.pone.0113203  0.32
2014 Lalani SR, Zhang J, Schaaf CP, Brown CW, Magoulas P, Tsai AC, El-Gharbawy A, Wierenga KJ, Bartholomew D, Fong CT, Barbaro-Dieber T, Kukolich MK, Burrage LC, Austin E, Keller K, ... ... Boerwinkle E, et al. Mutations in PURA cause profound neonatal hypotonia, seizures, and encephalopathy in 5q31.3 microdeletion syndrome. American Journal of Human Genetics. 95: 579-83. PMID 25439098 DOI: 10.1016/j.ajhg.2014.09.014  0.32
2014 Jian X, Boerwinkle E, Liu X. In silico prediction of splice-altering single nucleotide variants in the human genome. Nucleic Acids Research. 42: 13534-44. PMID 25416802 DOI: 10.1093/nar/gku1206  0.32
2014 Frau F, Zaninello R, Salvi E, Ortu MF, Braga D, Velayutham D, Argiolas G, Fresu G, Troffa C, Bulla E, Bulla P, Pitzoi S, Piras DA, Glorioso V, Chittani M, ... ... Boerwinkle E, et al. Genome-wide association study identifies CAMKID variants involved in blood pressure response to losartan: the SOPHIA study. Pharmacogenomics. 15: 1643-52. PMID 25410890 DOI: 10.2217/pgs.14.119  0.32
2014 Naik RP, Derebail VK, Grams ME, Franceschini N, Auer PL, Peloso GM, Young BA, Lettre G, Peralta CA, Katz R, Hyacinth HI, Quarells RC, Grove ML, Bick AG, Fontanillas P, ... ... Boerwinkle E, et al. Association of sickle cell trait with chronic kidney disease and albuminuria in African Americans. Jama. 312: 2115-25. PMID 25393378 DOI: 10.1001/jama.2014.15063  0.32
2014 Stitziel NO, Won HH, Morrison AC, Peloso GM, Do R, Lange LA, Fontanillas P, Gupta N, Duga S, Goel A, Farrall M, Saleheen D, Ferrario P, König I, ... ... Boerwinkle E, et al. Inactivating mutations in NPC1L1 and protection from coronary heart disease. The New England Journal of Medicine. 371: 2072-82. PMID 25390462 DOI: 10.1056/NEJMoa1405386  0.84
2014 Munir MS, Weng LC, Tang W, Basu S, Pankow JS, Matijevic N, Cushman M, Boerwinkle E, Folsom AR. Genetic markers associated with plasma protein C level in African Americans: the atherosclerosis risk in communities (ARIC) study. Genetic Epidemiology. 38: 709-13. PMID 25376901 DOI: 10.1002/gepi.21868  0.32
2014 Sheehan VA, Crosby JR, Sabo A, Mortier NA, Howard TA, Muzny DM, Dugan-Perez S, Aygun B, Nottage KA, Boerwinkle E, Gibbs RA, Ware RE, Flanagan JM. Whole exome sequencing identifies novel genes for fetal hemoglobin response to hydroxyurea in children with sickle cell anemia. Plos One. 9: e110740. PMID 25360671 DOI: 10.1371/journal.pone.0110740  0.32
2014 van Leeuwen EM, Smouter FA, Kam-Thong T, Karbalai N, Smith AV, Harris TB, Launer LJ, Sitlani CM, Li G, Brody JA, Bis JC, White CC, Jaiswal A, Oostra BA, Hofman A, ... ... Boerwinkle E, et al. The challenges of genome-wide interaction studies: lessons to learn from the analysis of HDL blood levels. Plos One. 9: e109290. PMID 25329471 DOI: 10.1371/journal.pone.0109290  0.32
2014 Yang Y, Muzny DM, Xia F, Niu Z, Person R, Ding Y, Ward P, Braxton A, Wang M, Buhay C, Veeraraghavan N, Hawes A, Chiang T, Leduc M, Beuten J, ... ... Boerwinkle E, et al. Molecular findings among patients referred for clinical whole-exome sequencing. Jama. 312: 1870-9. PMID 25326635 DOI: 10.1001/jama.2014.14601  0.32
2014 Morrison AC, Bis JC, Hwang SJ, Ehret GB, Lumley T, Rice K, Muzny D, Gibbs RA, Boerwinkle E, Psaty BM, Chakravarti A, Levy D. Sequence analysis of six blood pressure candidate regions in 4,178 individuals: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study. Plos One. 9: e109155. PMID 25275628 DOI: 10.1371/journal.pone.0109155  0.32
2014 Yamamoto S, Jaiswal M, Charng WL, Gambin T, Karaca E, Mirzaa G, Wiszniewski W, Sandoval H, Haelterman NA, Xiong B, Zhang K, Bayat V, David G, Li T, Chen K, ... ... Boerwinkle E, et al. A drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases. Cell. 159: 200-14. PMID 25259927 DOI: 10.1016/j.cell.2014.09.002  0.32
2014 Bose M, Wu C, Pankow JS, Demerath EW, Bressler J, Fornage M, Grove ML, Mosley TH, Hicks C, North K, Kao WH, Zhang Y, Boerwinkle E, Guan W. Evaluation of microarray-based DNA methylation measurement using technical replicates: the Atherosclerosis Risk In Communities (ARIC) Study. Bmc Bioinformatics. 15: 312. PMID 25239148 DOI: 10.1186/1471-2105-15-312  0.32
2014 Moore MJ, Gong Y, Hou W, Hall K, Schmidt SO, Curry RW, Beitelshees AL, Chapman A, Turner ST, Schwartz GL, Bailey K, Boerwinkle E, Gums JG, Cooper-DeHoff RM, Johnson JA. Predictors for glucose change in hypertensive participants following short-term treatment with atenolol or hydrochlorothiazide. Pharmacotherapy. 34: 1132-40. PMID 25202885 DOI: 10.1002/phar.1483  0.32
2014 Sørensen IF, Vazquez AI, Irvin MR, Sørensen P, Davis BR, Ford CE, Boerwinkle E, Eckfeldt JH, Arnett DK. Pharmacogenetic effects of 'candidate gene complexes' on stroke in the GenHAT study. Pharmacogenetics and Genomics. 24: 556-63. PMID 25171760 DOI: 10.1097/FPC.0000000000000088  0.32
2014 Rahbar MH, Samms-Vaughan M, Dickerson AS, Loveland KA, Ardjomand-Hessabi M, Bressler J, Shakespeare-Pellington S, Grove ML, Pearson DA, Boerwinkle E. Blood manganese concentrations in Jamaican children with and without autism spectrum disorders. Environmental Health : a Global Access Science Source. 13: 69. PMID 25149876 DOI: 10.1186/1476-069X-13-69  0.32
2014 Li Q, Liu X, Gibbs RA, Boerwinkle E, Polychronakos C, Qu HQ. Gene-specific function prediction for non-synonymous mutations in monogenic diabetes genes. Plos One. 9: e104452. PMID 25136813 DOI: 10.1371/journal.pone.0104452  0.32
2014 Ng MC, Shriner D, Chen BH, Li J, Chen WM, Guo X, Liu J, Bielinski SJ, Yanek LR, Nalls MA, Comeau ME, Rasmussen-Torvik LJ, Jensen RA, Evans DS, Sun YV, ... ... Boerwinkle E, et al. Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes. Plos Genetics. 10: e1004517. PMID 25102180 DOI: 10.1371/journal.pgen.1004517  0.44
2014 Rahbar MH, Samms-Vaughan M, Ma J, Bressler J, Loveland KA, Ardjomand-Hessabi M, Dickerson AS, Grove ML, Shakespeare-Pellington S, Beecher C, McLaughlin W, Boerwinkle E. Role of metabolic genes in blood arsenic concentrations of Jamaican children with and without autism spectrum disorder. International Journal of Environmental Research and Public Health. 11: 7874-95. PMID 25101770 DOI: 10.3390/ijerph110807874  0.32
2014 Rahbar MH, Samms-Vaughan M, Dickerson AS, Loveland KA, Ardjomand-Hessabi M, Bressler J, Lee M, Shakespeare-Pellington S, Grove ML, Pearson DA, Boerwinkle E. Role of fruits, grains, and seafood consumption in blood cadmium concentrations of Jamaican children with and without Autism Spectrum Disorder. Research in Autism Spectrum Disorders. 8: 1134-1145. PMID 25089152 DOI: 10.1016/j.rasd.2014.06.002  0.32
2014 Samocha KE, Robinson EB, Sanders SJ, Stevens C, Sabo A, McGrath LM, Kosmicki JA, Rehnström K, Mallick S, Kirby A, Wall DP, MacArthur DG, Gabriel SB, DePristo M, Purcell SM, ... ... Boerwinkle E, et al. A framework for the interpretation of de novo mutation in human disease. Nature Genetics. 46: 944-50. PMID 25086666 DOI: 10.1038/ng.3050  0.32
2014 Hoggart CJ, Venturini G, Mangino M, Gomez F, Ascari G, Zhao JH, Teumer A, Winkler TW, TÅ¡ernikova N, Luan J, Mihailov E, Ehret GB, Zhang W, Lamparter D, Esko T, ... ... Boerwinkle E, et al. Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index. Plos Genetics. 10: e1004508. PMID 25078964 DOI: 10.1371/journal.pgen.1004508  0.32
2014 Bayram Y, Pehlivan D, Karaca E, Gambin T, Jhangiani SN, Erdin S, Gonzaga-Jauregui C, Wiszniewski W, Muzny D, Elcioglu NH, Yildirim MS, Bozkurt B, Zamani AG, Boerwinkle E, et al. Whole exome sequencing identifies three novel mutations in ANTXR1 in families with GAPO syndrome. American Journal of Medical Genetics. Part A. 164: 2328-34. PMID 25045128 DOI: 10.1002/ajmg.a.36678  0.32
2014 Du M, Auer PL, Jiao S, Haessler J, Altshuler D, Boerwinkle E, Carlson CS, Carty CL, Chen YD, Curtis K, Franceschini N, Hsu L, Jackson R, Lange LA, Lettre G, et al. Whole-exome imputation of sequence variants identified two novel alleles associated with adult body height in African Americans. Human Molecular Genetics. 23: 6607-15. PMID 25027330 DOI: 10.1093/hmg/ddu361  0.32
2014 Yu B, Zheng Y, Nettleton JA, Alexander D, Coresh J, Boerwinkle E. Serum metabolomic profiling and incident CKD among African Americans. Clinical Journal of the American Society of Nephrology : Cjasn. 9: 1410-7. PMID 25011442 DOI: 10.2215/CJN.11971113  0.32
2014 Scharpf RB, Mireles L, Yang Q, Köttgen A, Ruczinski I, Susztak K, Halper-Stromberg E, Tin A, Cristiano S, Chakravarti A, Boerwinkle E, Fox CS, Coresh J, Linda Kao WH. Copy number polymorphisms near SLC2A9 are associated with serum uric acid concentrations. Bmc Genetics. 15: 81. PMID 25007794 DOI: 10.1186/1471-2156-15-81  0.32
2014 Kraja AT, Chasman DI, North KE, Reiner AP, Yanek LR, Kilpeläinen TO, Smith JA, Dehghan A, Dupuis J, Johnson AD, Feitosa MF, Tekola-Ayele F, Chu AY, Nolte IM, Dastani Z, ... ... Boerwinkle E, et al. Pleiotropic genes for metabolic syndrome and inflammation. Molecular Genetics and Metabolism. 112: 317-38. PMID 24981077 DOI: 10.1016/j.ymgme.2014.04.007  0.32
2014 Ganesh SK, Chasman DI, Larson MG, Guo X, Verwoert G, Bis JC, Gu X, Smith AV, Yang ML, Zhang Y, Ehret G, Rose LM, Hwang SJ, Papanicolau GJ, Sijbrands EJ, ... ... Boerwinkle E, et al. Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations. American Journal of Human Genetics. 95: 49-65. PMID 24975945 DOI: 10.1016/j.ajhg.2014.06.002  0.32
2014 Bis JC, DeStefano A, Liu X, Brody JA, Choi SH, Verhaaren BF, Debette S, Ikram MA, Shahar E, Butler KR, Gottesman RF, Muzny D, Kovar CL, Psaty BM, Hofman A, ... ... Boerwinkle E, et al. Associations of NINJ2 sequence variants with incident ischemic stroke in the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) consortium. Plos One. 9: e99798. PMID 24959832 DOI: 10.1371/journal.pone.0099798  0.32
2014 Simino J, Shi G, Bis JC, Chasman DI, Ehret GB, Gu X, Guo X, Hwang SJ, Sijbrands E, Smith AV, Verwoert GC, Bragg-Gresham JL, Cadby G, Chen P, Cheng CY, ... ... Boerwinkle E, et al. Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia. American Journal of Human Genetics. 95: 24-38. PMID 24954895 DOI: 10.1016/j.ajhg.2014.05.010  0.32
2014 Cornes BK, Brody JA, Nikpoor N, Morrison AC, Dang HC, Ahn BS, Wang S, Dauriz M, Barzilay JI, Dupuis J, Florez JC, Coresh J, Gibbs RA, Kao WH, Liu CT, ... ... Boerwinkle E, et al. Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. Circulation. Cardiovascular Genetics. 7: 374-82. PMID 24951664 DOI: 10.1161/CIRCGENETICS.113.000169  0.32
2014 Magnani JW, Brody JA, Prins BP, Arking DE, Lin H, Yin X, Liu CT, Morrison AC, Zhang F, Spector TD, Alonso A, Bis JC, Heckbert SR, Lumley T, Sitlani CM, ... ... Boerwinkle E, et al. Sequencing of SCN5A identifies rare and common variants associated with cardiac conduction: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Circulation. Cardiovascular Genetics. 7: 365-73. PMID 24951663 DOI: 10.1161/CIRCGENETICS.113.000098  0.32
2014 Bis JC, White CC, Franceschini N, Brody J, Zhang X, Muzny D, Santibanez J, Gibbs R, Liu X, Lin H, Boerwinkle E, Psaty BM, North KE, Cupples LA, O'Donnell CJ, et al. Sequencing of 2 subclinical atherosclerosis candidate regions in 3669 individuals: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. Circulation. Cardiovascular Genetics. 7: 359-64. PMID 24951662 DOI: 10.1161/CIRCGENETICS.113.000116  0.32
2014 Liu CT, Young KL, Brody JA, Olden M, Wojczynski MK, Heard-Costa N, Li G, Morrison AC, Muzny D, Gibbs RA, Reid JG, Shao Y, Zhou Y, Boerwinkle E, Heiss G, et al. Sequence variation in TMEM18 in association with body mass index: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. Circulation. Cardiovascular Genetics. 7: 344-9. PMID 24951660 DOI: 10.1161/CIRCGENETICS.13.000067  0.32
2014 Lin H, Wang M, Brody JA, Bis JC, Dupuis J, Lumley T, McKnight B, Rice KM, Sitlani CM, Reid JG, Bressler J, Liu X, Davis BC, Johnson AD, O'Donnell CJ, ... ... Boerwinkle E, et al. Strategies to design and analyze targeted sequencing data: cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. Circulation. Cardiovascular Genetics. 7: 335-43. PMID 24951659 DOI: 10.1161/CIRCGENETICS.113.000350  0.32
2014 Boerwinkle E, Heckbert SR. Following-up genome-wide association study signals lessons learned from cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium targeted sequencing study Circulation: Cardiovascular Genetics. 7: 332-334. PMID 24951658 DOI: 10.1161/CIRCGENETICS.113.000078  0.32
2014 Stray-Pedersen A, Backe PH, Sorte HS, Mørkrid L, Chokshi NY, Erichsen HC, Gambin T, Elgstøen KB, Bjørås M, Wlodarski MW, Krüger M, Jhangiani SN, Muzny DM, Patel A, Raymond KM, ... ... Boerwinkle EA, et al. PGM3 mutations cause a congenital disorder of glycosylation with severe immunodeficiency and skeletal dysplasia. American Journal of Human Genetics. 95: 96-107. PMID 24931394 DOI: 10.1016/j.ajhg.2014.05.007  0.32
2014 Xie YA, Lee W, Cai C, Gambin T, Nõupuu K, Sujirakul T, Ayuso C, Jhangiani S, Muzny D, Boerwinkle E, Gibbs R, Greenstein VC, Lupski JR, Tsang SH, Allikmets R. New syndrome with retinitis pigmentosa is caused by nonsense mutations in retinol dehydrogenase RDH11. Human Molecular Genetics. 23: 5774-80. PMID 24916380 DOI: 10.1093/hmg/ddu291  0.32
2014 Zheng Y, Yu B, Alexander D, Couper DJ, Boerwinkle E. Medium-term variability of the human serum metabolome in the Atherosclerosis Risk in Communities (ARIC) study. Omics : a Journal of Integrative Biology. 18: 364-73. PMID 24910946 DOI: 10.1089/omi.2014.0019  0.32
2014 Lusk CM, Dyson G, Clark AG, Ballantyne CM, Frikke-Schmidt R, Tybjærg-Hansen A, Boerwinkle E, Sing CF. Validated context-dependent associations of coronary heart disease risk with genotype variation in the chromosome 9p21 region: the Atherosclerosis Risk in Communities study. Human Genetics. 133: 1105-16. PMID 24889828 DOI: 10.1007/s00439-014-1451-3  0.32
2014 Kapoor A, Sekar RB, Hansen NF, Fox-Talbot K, Morley M, Pihur V, Chatterjee S, Brandimarto J, Moravec CS, Pulit SL, Pfeufer A, Mullikin J, Ross M, Green ED, ... ... Boerwinkle E, et al. An enhancer polymorphism at the cardiomyocyte intercalated disc protein NOS1AP locus is a major regulator of the QT interval. American Journal of Human Genetics. 94: 854-69. PMID 24857694 DOI: 10.1016/j.ajhg.2014.05.001  0.32
2014 Simino J, Kume R, Kraja AT, Turner ST, Hanis CL, Sheu WH, Chen YD, Jaquish CE, Cooper RS, Chakravarti A, Quertermous T, Boerwinkle E, Hunt SC, Rao DC. Linkage analysis incorporating gene-age interactions identifies seven novel lipid loci: the Family Blood Pressure Program. Atherosclerosis. 235: 84-93. PMID 24819747 DOI: 10.1016/j.atherosclerosis.2014.04.008  0.32
2014 Zhang F, Boerwinkle E, Xiong M. Epistasis analysis for quantitative traits by functional regression model. Genome Research. 24: 989-98. PMID 24803592 DOI: 10.1101/gr.161760.113  0.32
2014 Zheng Y, Yu B, Alexander D, Steffen LM, Boerwinkle E. Human metabolome associates with dietary intake habits among African Americans in the atherosclerosis risk in communities study. American Journal of Epidemiology. 179: 1424-33. PMID 24801555 DOI: 10.1093/aje/kwu073  0.32
2014 Xia F, Bainbridge MN, Tan TY, Wangler MF, Scheuerle AE, Zackai EH, Harr MH, Sutton VR, Nalam RL, Zhu W, Nash M, Ryan MM, Yaplito-Lee J, Hunter JV, Deardorff MA, ... ... Boerwinkle EA, et al. De novo truncating mutations in AHDC1 in individuals with syndromic expressive language delay, hypotonia, and sleep apnea. American Journal of Human Genetics. 94: 784-9. PMID 24791903 DOI: 10.1016/j.ajhg.2014.04.006  0.32
2014 Karaca E, Weitzer S, Pehlivan D, Shiraishi H, Gogakos T, Hanada T, Jhangiani SN, Wiszniewski W, Withers M, Campbell IM, Erdin S, Isikay S, Franco LM, Gonzaga-Jauregui C, Gambin T, ... ... Boerwinkle E, et al. Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function. Cell. 157: 636-50. PMID 24766809 DOI: 10.1016/j.cell.2014.02.058  0.32
2014 Zheng Y, Yu B, Alexander D, Steffen LM, Nettleton JA, Boerwinkle E. Metabolomic patterns and alcohol consumption in African Americans in the Atherosclerosis Risk in Communities Study. The American Journal of Clinical Nutrition. 99: 1470-8. PMID 24760976 DOI: 10.3945/ajcn.113.074070  0.32
2014 Sung YJ, Schwander K, Arnett DK, Kardia SL, Rankinen T, Bouchard C, Boerwinkle E, Hunt SC, Rao DC. An empirical comparison of meta-analysis and mega-analysis of individual participant data for identifying gene-environment interactions. Genetic Epidemiology. 38: 369-78. PMID 24719363 DOI: 10.1002/gepi.21800  0.32
2014 Rosenwasser RF, Shah NK, Smith SM, Wen X, Gong Y, Gums JG, Nichols WW, Chapman AB, Boerwinkle E, Johnson J, Epstein B. Baseline predictors of central aortic blood pressure: a PEAR substudy. Journal of the American Society of Hypertension : Jash. 8: 152-8. PMID 24629400 DOI: 10.1016/j.jash.2013.12.008  0.32
2014 Cooper-Dehoff RM, Hou W, Weng L, Baillie RA, Beitelshees AL, Gong Y, Shahin MH, Turner ST, Chapman A, Gums JG, Boyle SH, Zhu H, Wikoff WR, Boerwinkle E, Fiehn O, et al. Is diabetes mellitus-linked amino acid signature associated with β-blocker-induced impaired fasting glucose? Circulation. Cardiovascular Genetics. 7: 199-205. PMID 24627569 DOI: 10.1161/CIRCGENETICS.113.000421  0.32
2014 Yu B, Zheng Y, Alexander D, Morrison AC, Coresh J, Boerwinkle E. Genetic determinants influencing human serum metabolome among African Americans. Plos Genetics. 10: e1004212. PMID 24625756 DOI: 10.1371/journal.pgen.1004212  0.32
2014 Vandell AG, McDonough CW, Gong Y, Langaee TY, Lucas AM, Chapman AB, Gums JG, Beitelshees AL, Bailey KR, Johnson RJ, Boerwinkle E, Turner ST, Cooper-DeHoff RM, Johnson JA. Hydrochlorothiazide-induced hyperuricaemia in the pharmacogenomic evaluation of antihypertensive responses study. Journal of Internal Medicine. 276: 486-97. PMID 24612202 DOI: 10.1111/joim.12215  0.32
2014 Hoogeveen RC, Gaubatz JW, Sun W, Dodge RC, Crosby JR, Jiang J, Couper D, Virani SS, Kathiresan S, Boerwinkle E, Ballantyne CM. Small dense low-density lipoprotein-cholesterol concentrations predict risk for coronary heart disease: the Atherosclerosis Risk In Communities (ARIC) study. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 1069-77. PMID 24558110 DOI: 10.1161/ATVBAHA.114.303284  0.32
2014 Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD, Ng MC, Prokopenko I, ... ... Boerwinkle E, et al. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nature Genetics. 46: 234-44. PMID 24509480 DOI: 10.1038/ng.2897  0.32
2014 Peloso GM, Auer PL, Bis JC, Voorman A, Morrison AC, Stitziel NO, Brody JA, Khetarpal SA, Crosby JR, Fornage M, Isaacs A, Jakobsdottir J, Feitosa MF, Davies G, Huffman JE, ... ... Boerwinkle E, et al. Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. American Journal of Human Genetics. 94: 223-32. PMID 24507774 DOI: 10.1016/j.ajhg.2014.01.009  0.84
2014 Reid JG, Carroll A, Veeraraghavan N, Dahdouli M, Sundquist A, English A, Bainbridge M, White S, Salerno W, Buhay C, Yu F, Muzny D, Daly R, Duyk G, Gibbs RA, ... Boerwinkle E, et al. Launching genomics into the cloud: deployment of Mercury, a next generation sequence analysis pipeline. Bmc Bioinformatics. 15: 30. PMID 24475911 DOI: 10.1186/1471-2105-15-30  0.32
2014 Zhou Z, Yu F, Buchanan A, Fu Y, Campos M, Wu KK, Chambless LE, Folsom AR, Boerwinkle E, Dong JF. Possible race and gender divergence in association of genetic variations with plasma von Willebrand factor: a study of ARIC and 1000 genome cohorts. Plos One. 9: e84810. PMID 24465435 DOI: 10.1371/journal.pone.0084810  0.32
2014 Ibrahim-Verbaas CA, Fornage M, Bis JC, Choi SH, Psaty BM, Meigs JB, Rao M, Nalls M, Fontes JD, O'Donnell CJ, Kathiresan S, Ehret GB, Fox CS, Malik R, Dichgans M, ... ... Boerwinkle E, et al. Predicting stroke through genetic risk functions: the CHARGE Risk Score Project. Stroke; a Journal of Cerebral Circulation. 45: 403-12. PMID 24436238 DOI: 10.1161/STROKEAHA.113.003044  0.32
2014 Gazave E, Ma L, Chang D, Coventry A, Gao F, Muzny D, Boerwinkle E, Gibbs RA, Sing CF, Clark AG, Keinan A. Neutral genomic regions refine models of recent rapid human population growth. Proceedings of the National Academy of Sciences of the United States of America. 111: 757-62. PMID 24379384 DOI: 10.1073/pnas.1310398110  0.32
2014 Jian X, Boerwinkle E, Liu X. In silico tools for splicing defect prediction: a survey from the viewpoint of end users. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 16: 497-503. PMID 24263461 DOI: 10.1038/gim.2013.176  0.32
2014 Lin H, Sinner MF, Brody JA, Arking DE, Lunetta KL, Rienstra M, Lubitz SA, Magnani JW, Sotoodehnia N, McKnight B, McManus DD, Boerwinkle E, Psaty BM, Rotter JI, Bis JC, et al. Targeted sequencing in candidate genes for atrial fibrillation: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 11: 452-7. PMID 24239840 DOI: 10.1016/j.hrthm.2013.11.012  0.32
2014 Shalev SA, Tenenbaum-Rakover Y, Horovitz Y, Paz VP, Ye H, Carmody D, Highland HM, Boerwinkle E, Hanis CL, Muzny DM, Gibbs RA, Bell GI, Philipson LH, Greeley SA. Microcephaly, epilepsy, and neonatal diabetes due to compound heterozygous mutations in IER3IP1: insights into the natural history of a rare disorder. Pediatric Diabetes. 15: 252-6. PMID 24138066 DOI: 10.1111/pedi.12086  0.32
2014 Gong Y, McDonough CW, Beitelshees AL, Karnes JH, O'Connell JR, Turner ST, Chapman AB, Gums JG, Bailey KR, Boerwinkle E, Johnson JA, Cooper-DeHoff RM. PROX1 gene variant is associated with fasting glucose change after antihypertensive treatment. Pharmacotherapy. 34: 123-30. PMID 24122840 DOI: 10.1002/phar.1355  0.32
2014 Simino J, Shi G, Weder A, Boerwinkle E, Hunt SC, Rao DC. Body mass index modulates blood pressure heritability: the Family Blood Pressure Program. American Journal of Hypertension. 27: 610-9. PMID 24029162 DOI: 10.1093/ajh/hpt144  0.32
2014 Chapman AB, Cotsonis G, Parekh V, Schwartz GL, Gong Y, Bailey KR, Turner ST, Gums JG, Beitelshees AL, Cooper-DeHoff R, Boerwinkle E, Johnson JA. Night blood pressure responses to atenolol and hydrochlorothiazide in black and white patients with essential hypertension. American Journal of Hypertension. 27: 546-54. PMID 23886594 DOI: 10.1093/ajh/hpt124  0.32
2014 Avery CL, Sitlani CM, Arking DE, Arnett DK, Bis JC, Boerwinkle E, Buckley BM, Ida Chen YD, de Craen AJ, Eijgelsheim M, Enquobahrie D, Evans DS, Ford I, Garcia ME, Gudnason V, et al. Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. The Pharmacogenomics Journal. 14: 6-13. PMID 23459443 DOI: 10.1038/tpj.2013.4  0.32
2014 Del-Aguila JL, Beitelshees AL, Cooper-Dehoff RM, Chapman AB, Gums JG, Bailey K, Gong Y, Turner ST, Johnson JA, Boerwinkle E. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. The Pharmacogenomics Journal. 14: 35-40. PMID 23400010 DOI: 10.1038/tpj.2013.3  0.32
2014 Rodenburg EM, Hofland J, Van Noord C, Visser LE, Dehghan A, Barbalic M, Jan Danser AH, Lawson KS, Hofman A, Witteman J, Boerwinkle E, Uitterlinden AG, Stricker BH, De Jong FH. Sex-specific differences in the effects of local androgen metabolism in the heart as an indicator for the risk of myocardial infarction Cardiovascular Endocrinology. 3: 134-141. DOI: 10.1097/XCE.0000000000000037  0.32
2014 Gonzaga-Jauregui C, Harel T, Gambin T, Kousi M, Griffin L, Francescatto L, Ozes B, Karaca E, Jhangiani SN, Bainbridge M, Lawson K, Pehlivan D, Okamoto Y, Withers M, Mancias P, ... ... Boerwinkle E, et al. Exome Sequence Analysis Suggests that Genetic Burden Contributes to Phenotypic Variability and Complex Neuropathy Cell Reports. DOI: 10.1016/j.celrep.2015.07.023  0.32
2013 Bressler J, Pankow JS, Coresh J, Boerwinkle E. Interaction between the NOS3 gene and obesity as a determinant of risk of type 2 diabetes: the Atherosclerosis Risk in Communities study. Plos One. 8: e79466. PMID 24278136 DOI: 10.1371/journal.pone.0079466  0.32
2013 Han S, Yang BZ, Kranzler HR, Liu X, Zhao H, Farrer LA, Boerwinkle E, Potash JB, Gelernter J. Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependence. American Journal of Human Genetics. 93: 1027-34. PMID 24268660 DOI: 10.1016/j.ajhg.2013.10.021  0.32
2013 Stephens SH, Hartz SM, Hoft NR, Saccone NL, Corley RC, Hewitt JK, Hopfer CJ, Breslau N, Coon H, Chen X, Ducci F, Dueker N, Franceschini N, Frank J, Han Y, ... ... Boerwinkle E, et al. Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking. Genetic Epidemiology. 37: 846-59. PMID 24186853 DOI: 10.1002/gepi.21760  0.32
2013 Maxwell TJ, Ballantyne CM, Cheverud JM, Guild CS, Ndumele CE, Boerwinkle E. APOE modulates the correlation between triglycerides, cholesterol, and CHD through pleiotropy, and gene-by-gene interactions. Genetics. 195: 1397-405. PMID 24097412 DOI: 10.1534/genetics.113.157719  0.32
2013 Gong J, Schumacher F, Lim U, Hindorff LA, Haessler J, Buyske S, Carlson CS, Rosse S, Bůžková P, Fornage M, Gross M, Pankratz N, Pankow JS, Schreiner PJ, Cooper R, ... ... Boerwinkle E, et al. Fine Mapping and Identification of BMI Loci in African Americans. American Journal of Human Genetics. 93: 661-71. PMID 24094743 DOI: 10.1016/j.ajhg.2013.08.012  0.32
2013 Nambi V, Liu X, Chambless LE, de Lemos JA, Virani SS, Agarwal S, Boerwinkle E, Hoogeveen RC, Aguilar D, Astor BC, Srinivas PR, Deswal A, Mosley TH, Coresh J, Folsom AR, et al. Troponin T and N-terminal pro-B-type natriuretic peptide: a biomarker approach to predict heart failure risk--the atherosclerosis risk in communities study. Clinical Chemistry. 59: 1802-10. PMID 24036936 DOI: 10.1373/clinchem.2013.203638  0.32
2013 Parsa A, Fuchsberger C, Köttgen A, O'Seaghdha CM, Pattaro C, de Andrade M, Chasman DI, Teumer A, Endlich K, Olden M, Chen MH, Tin A, Kim YJ, Taliun D, Li M, ... ... Boerwinkle E, et al. Common variants in Mendelian kidney disease genes and their association with renal function. Journal of the American Society of Nephrology : Jasn. 24: 2105-17. PMID 24029420 DOI: 10.1681/ASN.2012100983  0.32
2013 Hamilton PJ, Campbell NG, Sharma S, Erreger K, Herborg Hansen F, Saunders C, Belovich AN, Sahai MA, Cook EH, Gether U, McHaourab HS, Matthies HJ, Sutcliffe JS, Galli A. De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder. Molecular Psychiatry. 18: 1315-23. PMID 23979605 DOI: 10.1038/mp.2013.102  0.32
2013 Franceschini N, Fox E, Zhang Z, Edwards TL, Nalls MA, Sung YJ, Tayo BO, Sun YV, Gottesman O, Adeyemo A, Johnson AD, Young JH, Rice K, Duan Q, Chen F, ... ... Boerwinkle E, et al. Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations. American Journal of Human Genetics. 93: 545-54. PMID 23972371 DOI: 10.1016/j.ajhg.2013.07.010  0.32
2013 Sabater-Lleal M, Huang J, Chasman D, Naitza S, Dehghan A, Johnson AD, Teumer A, Reiner AP, Folkersen L, Basu S, Rudnicka AR, Trompet S, Mälarstig A, Baumert J, Bis JC, ... ... Boerwinkle E, et al. Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. Circulation. 128: 1310-24. PMID 23969696 DOI: 10.1161/CIRCULATIONAHA.113.002251  0.32
2013 Yu B, Zheng Y, Alexander D, Manolio TA, Alonso A, Nettleton JA, Boerwinkle E. Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. Genetic Epidemiology. 37: 840-5. PMID 23934736 DOI: 10.1002/gepi.21752  0.32
2013 Agopian AJ, Bhalla AD, Boerwinkle E, Finnell RH, Grove ML, Hixson JE, Shimmin LC, Sewda A, Stuart C, Zhong Y, Zhu H, Mitchell LE. Exon sequencing of PAX3 and T (brachyury) in cases with spina bifida. Birth Defects Research. Part a, Clinical and Molecular Teratology. 97: 597-601. PMID 23913553 DOI: 10.1002/bdra.23163  0.32
2013 Virani SS, Lee VV, Brautbar A, Grove ML, Nambi V, Alam M, Elayda M, Wilson JM, Willerson JT, Boerwinkle E, Ballantyne CM. Single nucleotide polymorphisms in cholesteryl ester transfer protein gene and recurrent coronary heart disease or mortality in patients with established atherosclerosis. The American Journal of Cardiology. 112: 1287-92. PMID 23891427 DOI: 10.1016/j.amjcard.2013.05.073  0.32
2013 Dadu RT, Dodge R, Nambi V, Virani SS, Hoogeveen RC, Smith NL, Chen F, Pankow JS, Guild C, Tang WH, Boerwinkle E, Hazen SL, Ballantyne CM. Ceruloplasmin and heart failure in the Atherosclerosis Risk in Communities study. Circulation. Heart Failure. 6: 936-43. PMID 23861484 DOI: 10.1161/CIRCHEARTFAILURE.113.000270  0.32
2013 Liu X, Jian X, Boerwinkle E. dbNSFP v2.0: a database of human non-synonymous SNVs and their functional predictions and annotations. Human Mutation. 34: E2393-402. PMID 23843252 DOI: 10.1002/humu.22376  0.32
2013 Zheng Y, Yu B, Alexander D, Manolio TA, Aguilar D, Coresh J, Heiss G, Boerwinkle E, Nettleton JA. Associations between metabolomic compounds and incident heart failure among African Americans: the ARIC Study. American Journal of Epidemiology. 178: 534-42. PMID 23788672 DOI: 10.1093/aje/kwt004  0.32
2013 Morrison AC, Voorman A, Johnson AD, Liu X, Yu J, Li A, Muzny D, Yu F, Rice K, Zhu C, Bis J, Heiss G, O'Donnell CJ, Psaty BM, Cupples LA, ... ... Boerwinkle E, et al. Whole-genome sequence-based analysis of high-density lipoprotein cholesterol. Nature Genetics. 45: 899-901. PMID 23770607 DOI: 10.1038/ng.2671  0.32
2013 Foster MC, Coresh J, Fornage M, Astor BC, Grams M, Franceschini N, Boerwinkle E, Parekh RS, Kao WH. APOL1 variants associate with increased risk of CKD among African Americans. Journal of the American Society of Nephrology : Jasn. 24: 1484-91. PMID 23766536 DOI: 10.1681/ASN.2013010113  0.32
2013 Johnsen JM, Auer PL, Morrison AC, Jiao S, Wei P, Haessler J, Fox K, McGee SR, Smith JD, Carlson CS, Smith N, Boerwinkle E, Kooperberg C, Nickerson DA, Rich SS, et al. Common and rare von Willebrand factor (VWF) coding variants, VWF levels, and factor VIII levels in African Americans: the NHLBI Exome Sequencing Project. Blood. 122: 590-7. PMID 23690449 DOI: 10.1182/blood-2013-02-485094  0.32
2013 Nguyen KD, Pihur V, Ganesh SK, Rakha A, Cooper RS, Hunt SC, Freedman BI, Coresh J, Kao WH, Morrison AC, Boerwinkle E, Ehret GB, Chakravarti A. Effects of rare and common blood pressure gene variants on essential hypertension: results from the Family Blood Pressure Program, CLUE, and Atherosclerosis Risk in Communities studies. Circulation Research. 112: 318-26. PMID 23149595 DOI: 10.1161/CIRCRESAHA.112.276725  0.32
2013 Karnes JH, McDonough CW, Gong Y, Vo TT, Langaee TY, Chapman AB, Gums JG, Beitelshees AL, Bailey KR, Del-Aguila JL, Boerwinkle EA, Pepine CJ, Turner ST, Johnson JA, Cooper-DeHoff RM. Association of KCNJ1 variation with change in fasting glucose and new onset diabetes during HCTZ treatment. The Pharmacogenomics Journal. 13: 430-6. PMID 22907731 DOI: 10.1038/tpj.2012.34  0.32
2013 Tang W, Morrison A, Wasserman BA, Folsom AR, Sun W, Campbell S, Linda Kao WH, Boerwinkle E. Association of SERPINA9 gene variants with carotid artery atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study International Journal of Molecular Epidemiology and Genetics. 4: 258-267.  0.32
2012 Shetty PB, Tang H, Tayo BO, Morrison AC, Hanis CL, Rao DC, Young JH, Fox ER, Boerwinkle E, Cooper RS, Risch NJ, Zhu X. Variants in CXADR and F2RL1 are associated with blood pressure and obesity in African-Americans in regions identified through admixture mapping. Journal of Hypertension. 30: 1970-6. PMID 22914544 DOI: 10.1097/HJH.0b013e3283578c80  0.32
2007 Kardia SL, Sun YV, Hamon SC, Barkley RA, Boerwinkle E, Turner ST. Interactions between the adducin 2 gene and antihypertensive drug therapies in determining blood pressure in people with hypertension. Bmc Medical Genetics. 8: 61. PMID 17854487 DOI: 10.1186/1471-2350-8-61  0.32
2007 Arnett DK, Baird AE, Barkley RA, Basson CT, Boerwinkle E, Ganesh SK, Herrington DM, Hong Y, Jaquish C, McDermott DA, O'Donnell CJ. Relevance of genetics and genomics for prevention and treatment of cardiovascular disease: a scientific statement from the American Heart Association Council on Epidemiology and Prevention, the Stroke Council, and the Functional Genomics and Translational Biology Interdisciplinary Working Group. Circulation. 115: 2878-901. PMID 17515457 DOI: 10.1161/CIRCULATIONAHA.107.183679  0.32
2006 Volcik KA, Barkley RA, Hutchinson RG, Mosley TH, Heiss G, Sharrett AR, Ballantyne CM, Boerwinkle E. Apolipoprotein E polymorphisms predict low density lipoprotein cholesterol levels and carotid artery wall thickness but not incident coronary heart disease in 12,491 ARIC study participants. American Journal of Epidemiology. 164: 342-8. PMID 16760224 DOI: 10.1093/aje/kwj202  0.32
2004 Barkley RA, Chakravarti A, Cooper RS, Ellison RC, Hunt SC, Province MA, Turner ST, Weder AB, Boerwinkle E. Positional identification of hypertension susceptibility genes on chromosome 2. Hypertension. 43: 477-82. PMID 14732741 DOI: 10.1161/01.HYP.0000111585.76299.f7  0.32
2003 Huang Q, Fu YX, Boerwinkle E. Comparison of strategies for selecting single nucleotide polymorphisms for case/control association studies. Human Genetics. 113: 253-7. PMID 12811538 DOI: 10.1007/s00439-003-0965-x  0.84
2003 Barkley RA, Brown AC, Hanis CL, Kardia SL, Turner ST, Boerwinkle E. Lack of genetic linkage evidence for a trans-acting factor having a large effect on plasma lipoprotein[a] levels in African Americans. Journal of Lipid Research. 44: 1301-5. PMID 12730294 DOI: 10.1194/jlr.M300163-JLR200  0.32
2001 Huang Q, Morrison AC, Boerwinkle E. Linkage disequilibrium structure and its impact on the localization of a candidate functional mutation. Genetic Epidemiology. 21: S620-5. PMID 11793750  0.84
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