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Ying Lai, Ph.D. - Publications

Affiliations: 
2013 Biochemistry, Biophysics, and Molecular Biology Iowa State University, Ames, IA, United States 
Area:
Biochemistry, General Biophysics
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39 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Li K, Li K, Fan J, Zhang X, Tao C, Xiang Y, Cui L, Li H, Li M, Zhang Y, Geng J, Lai Y. Synergistic regulation of fusion pore opening and dilation by SNARE and synaptotagmin-1. Journal of Molecular Cell Biology. PMID 38444183 DOI: 10.1093/jmcb/mjae011  0.461
2023 Wu M, Li W, Lin S, Fan J, Cui L, Xiang Y, Li K, Tang L, Duan Y, Chen Z, Yang F, Shui W, Lu G, Lai Y. A Suitable Membrane Distance Regulated by the RBD_ACE2 Interaction is Critical for SARS-CoV-2 Spike-Mediated Viral Invasion. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2301478. PMID 37590389 DOI: 10.1002/advs.202301478  0.38
2022 Cui L, Li H, Xi Y, Hu Q, Liu H, Fan J, Xiang Y, Zhang X, Shui W, Lai Y. Vesicle trafficking and vesicle fusion: mechanisms, biological functions, and their implications for potential disease therapy. Molecular Biomedicine. 3: 29. PMID 36129576 DOI: 10.1186/s43556-022-00090-3  0.438
2022 Lai Y, Tuvim MJ, Leitz J, Peters J, Pfuetzner RA, Esquivies L, Zhou Q, Czako B, Cross JB, Jones P, Dickey BF, Brunger AT. Screening of Hydrocarbon-Stapled Peptides for Inhibition of Calcium-Triggered Exocytosis. Frontiers in Pharmacology. 13: 891041. PMID 35814209 DOI: 10.3389/fphar.2022.891041  0.359
2022 Lai Y, Fois G, Flores JR, Tuvim MJ, Zhou Q, Yang K, Leitz J, Peters J, Zhang Y, Pfuetzner RA, Esquivies L, Jones P, Frick M, Dickey BF, Brunger AT. Inhibition of calcium-triggered secretion by hydrocarbon-stapled peptides. Nature. 603: 949-956. PMID 35322233 DOI: 10.1038/s41586-022-04543-1  0.379
2020 Lai Y, Fois G, Frick M, Dickey B, Brunger AT. Inhibition of Airway Epithelial Snare/Synaptotagmin Mediated Membrane Fusion by Hydrocarbon-Stapled Peptides Biophysical Journal. 118: 399a-400a. DOI: 10.1016/J.Bpj.2019.11.2269  0.39
2019 Brunger AT, Choi UB, Lai Y, Leitz J, White KI, Zhou Q. The pre-synaptic fusion machinery. Current Opinion in Structural Biology. 54: 179-188. PMID 30986753 DOI: 10.1016/J.Sbi.2019.03.007  0.455
2018 Brunger AT, Choi UB, Lai Y, Leitz J, Zhou Q. Molecular Mechanisms of Fast Neurotransmitter Release. Annual Review of Biophysics. 47: 469-497. PMID 29792815 DOI: 10.1146/Annurev-Biophys-070816-034117  0.446
2018 Brunger AT, Leitz J, Zhou Q, Choi UB, Lai Y. Ca-Triggered Synaptic Vesicle Fusion Initiated by Release of Inhibition. Trends in Cell Biology. PMID 29706534 DOI: 10.1016/J.Tcb.2018.03.004  0.541
2017 Hu Y, Lai Y, Wang Y, Zhao M, Zhang Y, Crowe M, Tian Z, Long J, Diao J. SNARE-Reconstituted Liposomes as Controllable Zeptoliter Nanoreactors for Macromolecules. Advanced Biosystems. 1: e1600018. PMID 32646184 DOI: 10.1002/adbi.201600018  0.375
2017 Lai Y, Choi UB, Leitz J, Rhee HJ, Lee C, Altas B, Zhao M, Pfuetzner RA, Wang AL, Brose N, Rhee J, Brunger AT. Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18. Neuron. 95: 591-607.e10. PMID 28772123 DOI: 10.1016/J.Neuron.2017.07.004  0.47
2017 Gipson P, Fukuda Y, Danev R, Lai Y, Chen DH, Baumeister W, Brunger AT. Morphologies of synaptic protein membrane fusion interfaces. Proceedings of the National Academy of Sciences of the United States of America. PMID 28739947 DOI: 10.1073/Pnas.1708492114  0.469
2017 Lai Y. Munc13 And Munc18 Cooperate to Properly Assemble SNAREs for Fast Neurotransmitter Release Biophysical Journal. 112: 90a. DOI: 10.1016/J.Bpj.2016.11.531  0.48
2017 Crowe M, Lai Y, Wang Y, Lu J, Zhao M, Tian Z, Long J, Zhang P, Diao J. A Proteoliposome Method for Assessing Nanotoxicity on Synaptic Fusion and Membrane Integrity Small Methods. 1: 1700207. DOI: 10.1002/smtd.201700207  0.301
2016 Gong J, Lai Y, Li X, Wang M, Leitz J, Hu Y, Zhang Y, Choi UB, Cipriano D, Pfuetzner RA, Südhof TC, Yang X, Brunger AT, Diao J. C-terminal domain of mammalian complexin-1 localizes to highly curved membranes. Proceedings of the National Academy of Sciences of the United States of America. 113: E7590-E7599. PMID 27821736 DOI: 10.1073/Pnas.1609917113  0.456
2016 Lai Y, Choi UB, Zhang Y, Zhao M, Pfuetzner RA, Wang AL, Diao J, Brunger AT. N-terminal domain of complexin independently activates calcium-triggered fusion. Proceedings of the National Academy of Sciences of the United States of America. PMID 27444020 DOI: 10.1073/Pnas.1604348113  0.495
2016 Wang Y, Li L, Hou C, Lai Y, Long J, Liu J, Zhong Q, Diao J. SNARE-mediated membrane fusion in autophagy. Seminars in Cell & Developmental Biology. PMID 27422330 DOI: 10.1016/J.Semcdb.2016.07.009  0.438
2016 Malmersjö S, Di Palma S, Diao J, Lai Y, Pfuetzner RA, Wang AL, McMahon MA, Hayer A, Porteus M, Bodenmiller B, Brunger AT, Meyer T. Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion. The Embo Journal. PMID 27402227 DOI: 10.15252/Embj.201694071  0.452
2016 Choi UB, Zhao M, Zhang Y, Lai Y, Brunger AT. Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex. Elife. 5. PMID 27253060 DOI: 10.7554/Elife.16886  0.434
2016 Li Y, Li Y, Chen D, Jin L, Su Z, Liu J, Duan H, Li X, Qi Z, Shi M, Ni L, Yang S, Gui Y, Mao X, Chen Y, ... Lai Y, et al. miR‑30a‑5p in the tumorigenesis of renal cell carcinoma: A tumor suppressive microRNA. Molecular Medicine Reports. PMID 27035333 DOI: 10.3892/mmr.2016.5024  0.441
2016 Li Y, Chen D, Li Y, Jin L, Liu J, Su Z, Qi Z, Shi M, Jiang Z, Ni L, Yang S, Gui Y, Mao X, Chen Y, Lai Y. Oncogenic cAMP responsive element binding protein 1 is overexpressed upon loss of tumor suppressive miR-10b-5p and miR-363-3p in renal cancer. Oncology Reports. PMID 26796749 DOI: 10.3892/or.2016.4579  0.461
2016 Choi UB, Zhao M, Zhang Y, Lai Y, Brunger AT. Author response: Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex Elife. DOI: 10.7554/Elife.16886.022  0.387
2016 Li Y, Jin L, Liu J, Chen D, Su Z, Zhou L, Shi B, Lai Y. Bellini’s duct carcinoma: A report of two cases and a review of the literature Oncology Letters. 11: 3839-3841. DOI: 10.3892/ol.2016.4454  0.425
2016 Zhang Y, Guo P, Shao Y, Lai Y, Zhang J. Preparation and high-temperature performance of Co-10Mn and Co-40Mn alloy coatings for solid oxide fuel cell metal interconnects Journal of Alloys and Compounds. 680: 685-693. DOI: 10.1016/j.jallcom.2016.04.183  0.342
2015 Zhou Q, Lai Y, Bacaj T, Zhao M, Lyubimov AY, Uervirojnangkoorn M, Zeldin OB, Brewster AS, Sauter NK, Cohen AE, Soltis SM, Alonso-Mori R, Chollet M, Lemke HT, Pfuetzner RA, et al. Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis. Nature. 525: 62-7. PMID 26280336 DOI: 10.1038/Nature14975  0.486
2015 Lai Y, Zhao L, Bu B, Lou X, Li D, Ji B, Liu J, Diao J, Shin YK. Lipid molecules influence early stages of yeast SNARE-mediated membrane fusion. Physical Biology. 12: 025003. PMID 25898400 DOI: 10.1088/1478-3975/12/2/025003  0.625
2015 Lai Y, Lou X, Diao J, Shin YK. Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening. Scientific Reports. 5: 9267. PMID 25791821 DOI: 10.1038/Srep09267  0.688
2015 Zhang Y, Diao J, Colbert KN, Lai Y, Pfuetzner RA, Padolina MS, Vivona S, Ressl S, Cipriano DJ, Choi UB, Shah N, Weis WI, Brunger AT. Munc18a does not alter fusion rates mediated by neuronal SNAREs, synaptotagmin, and complexin. The Journal of Biological Chemistry. 290: 10518-34. PMID 25716318 DOI: 10.1074/Jbc.M114.630772  0.475
2015 Diao J, Liu R, Rong Y, Zhao M, Zhang J, Lai Y, Zhou Q, Wilz LM, Li J, Vivona S, Pfuetzner RA, Brunger AT, Zhong Q. ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes. Nature. 520: 563-6. PMID 25686604 DOI: 10.1038/Nature14147  0.513
2014 Lai Y, Diao J, Cipriano DJ, Zhang Y, Pfuetzner RA, Padolina MS, Brunger AT. Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms. Elife. 3: e03756. PMID 25122624 DOI: 10.7554/Elife.03756  0.531
2014 Lai Y, Kim S, Varkey J, Lou X, Song JK, Diao J, Langen R, Shin YK. Nonaggregated α-synuclein influences SNARE-dependent vesicle docking via membrane binding. Biochemistry. 53: 3889-96. PMID 24884175 DOI: 10.1021/Bi5002536  0.713
2014 Lai Y, Lou X, Wang C, Xia T, Tong J. Synaptotagmin 1 and Ca2+ drive trans SNARE zippering. Scientific Reports. 4: 4575. PMID 24694579 DOI: 10.1038/Srep04575  0.669
2014 Lai Y, Diao J, Cipriano DJ, Zhang Y, Pfuetzner RA, Padolina MS, Brunger AT. Author response: Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms Elife. DOI: 10.7554/Elife.03756.010  0.474
2013 Lai Y, Lou X, Jho Y, Yoon TY, Shin YK. The synaptotagmin 1 linker may function as an electrostatic zipper that opens for docking but closes for fusion pore opening. The Biochemical Journal. 456: 25-33. PMID 24001110 DOI: 10.1042/Bj20130949  0.609
2013 Choi BK, Choi MG, Kim JY, Yang Y, Lai Y, Kweon DH, Lee NK, Shin YK. Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking. Proceedings of the National Academy of Sciences of the United States of America. 110: 4087-92. PMID 23431141 DOI: 10.1073/Pnas.1218424110  0.6
2013 Lai Y, Diao J, Liu Y, Ishitsuka Y, Su Z, Schulten K, Ha T, Shin YK. Fusion pore formation and expansion induced by Ca2+ and synaptotagmin 1. Proceedings of the National Academy of Sciences of the United States of America. 110: 1333-8. PMID 23300284 DOI: 10.1073/Pnas.1218818110  0.723
2012 Kim JY, Choi BK, Choi MG, Kim SA, Lai Y, Shin YK, Lee NK. Solution single-vesicle assay reveals PIP2-mediated sequential actions of synaptotagmin-1 on SNAREs. The Embo Journal. 31: 2144-55. PMID 22407297 DOI: 10.1038/Emboj.2012.57  0.735
2012 Lai Y, Shin YK. The importance of an asymmetric distribution of acidic lipids for synaptotagmin 1 function as a Ca2+ sensor. The Biochemical Journal. 443: 223-9. PMID 22229667 DOI: 10.1042/Bj20112044  0.656
2010 Diao J, Su Z, Ishitsuka Y, Lu B, Lee KS, Lai Y, Shin YK, Ha T. A single-vesicle content mixing assay for SNARE-mediated membrane fusion. Nature Communications. 1: 54. PMID 20975723 DOI: 10.1038/Ncomms1054  0.707
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