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Joseph A. Chemler, Ph.D. - Publications

Affiliations: 
2009 Chemical and Biological Engineering State University of New York, Buffalo, Buffalo, NY, United States 
Area:
Chemical Engineering, Biochemistry, Microbiology Biology
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18 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Sherman DH, Koch AA, Schmidt J, Lowell A, Hansen D, Coburn K, Chemler J. Probing Selectivity and Creating Structural Diversity Through Hybrid Polyketide Synthases. Angewandte Chemie (International Ed. in English). PMID 32357274 DOI: 10.1002/Anie.202004991  0.411
2018 Ratnayake AS, Chang LP, Tumey LN, Loganzo F, Chemler JA, Wagenaar M, Musto S, Li F, Janso JE, Ballard TE, Rago B, Steele GL, Ding W, Feng X, Hosselet C, et al. Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody-Drug Conjugates. Bioconjugate Chemistry. PMID 30543418 DOI: 10.1021/Acs.Bioconjchem.8B00843  0.321
2017 Lowell AN, DeMars MD, Slocum ST, Yu F, Anand K, Chemler JA, Korakavi N, Priessnitz JK, Park SR, Koch AA, Schultz PJ, Sherman DH. Chemoenzymatic total synthesis and structural diversification of tylactone-based macrolide antibiotics through late-stage polyketide assembly, tailoring, and C-H functionalization. Journal of the American Chemical Society. PMID 28525276 DOI: 10.1021/Jacs.7B02875  0.347
2017 Koryakina I, Kasey C, McArthur JB, Lowell AN, Chemler JA, Li S, Hansen DA, Sherman DH, Williams GJ. Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering. Acs Chemical Biology. 12: 114-123. PMID 28103677 DOI: 10.1021/Acschembio.6B00732  0.418
2015 Chemler JA, Tripathi A, Hansen DA, O'Neil-Johnson M, Williams RB, Starks C, Park SR, Sherman DH. Evolution of Efficient Modular Polyketide Synthases by Homeologous Recombination. Journal of the American Chemical Society. PMID 26230368 DOI: 10.1021/Jacs.5B04842  0.501
2014 Whicher JR, Dutta S, Hansen DA, Hale WA, Chemler JA, Dosey AM, Narayan AR, Håkansson K, Sherman DH, Smith JL, Skiniotis G. Structural rearrangements of a polyketide synthase module during its catalytic cycle. Nature. 510: 560-4. PMID 24965656 DOI: 10.1038/Nature13409  0.38
2014 Dutta S, Whicher JR, Hansen DA, Hale WA, Chemler JA, Congdon GR, Narayan AR, Håkansson K, Sherman DH, Smith JL, Skiniotis G. Structure of a modular polyketide synthase. Nature. 510: 512-7. PMID 24965652 DOI: 10.1038/Nature13423  0.377
2012 Chemler JA, Buchholz TJ, Geders TW, Akey DL, Rath CM, Chlipala GE, Smith JL, Sherman DH. Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donor. Journal of the American Chemical Society. 134: 7359-66. PMID 22480290 DOI: 10.1021/Ja2112228  0.417
2011 Bonnett SA, Rath CM, Shareef AR, Joels JR, Chemler JA, Håkansson K, Reynolds K, Sherman DH. Acyl-CoA subunit selectivity in the pikromycin polyketide synthase PikAIV: steady-state kinetics and active-site occupancy analysis by FTICR-MS. Chemistry & Biology. 18: 1075-81. PMID 21944746 DOI: 10.1016/J.Chembiol.2011.07.016  0.361
2010 Chemler JA, Lim CG, Daiss JL, Koffas MA. A versatile microbial system for biosynthesis of novel polyphenols with altered estrogen receptor binding activity. Chemistry & Biology. 17: 392-401. PMID 20416510 DOI: 10.1016/J.Chembiol.2010.03.010  0.573
2010 Chemler JA, Fowler ZL, McHugh KP, Koffas MA. Improving NADPH availability for natural product biosynthesis in Escherichia coli by metabolic engineering. Metabolic Engineering. 12: 96-104. PMID 19628048 DOI: 10.1016/J.Ymben.2009.07.003  0.701
2008 Chemler JA, Koffas MA. Metabolic engineering for plant natural product biosynthesis in microbes. Current Opinion in Biotechnology. 19: 597-605. PMID 18992815 DOI: 10.1016/J.Copbio.2008.10.011  0.651
2008 Leonard E, Yan Y, Chemler J, Matern U, Martens S, Koffas MA. Characterization of dihydroflavonol 4-reductases for recombinant plant pigment biosynthesis applications Biocatalysis and Biotransformation. 26: 243-251. DOI: 10.1080/10242420701685635  0.719
2007 Chemler JA, Lock LT, Koffas MA, Tzanakakis ES. Standardized biosynthesis of flavan-3-ols with effects on pancreatic beta-cell insulin secretion. Applied Microbiology and Biotechnology. 77: 797-807. PMID 17938905 DOI: 10.1007/S00253-007-1227-Y  0.65
2007 Chemler JA, Yan Y, Leonard E, Koffas MA. Combinatorial mutasynthesis of flavonoid analogues from acrylic acids in microorganisms. Organic Letters. 9: 1855-8. PMID 17447772 DOI: 10.1021/Ol0703736  0.703
2006 Chemler JA, Yan Y, Koffas MA. Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae. Microbial Cell Factories. 5: 20. PMID 16719921 DOI: 10.1186/1475-2859-5-20  0.675
2006 Leonard E, Chemler J, Lim KH, Koffas MA. Expression of a soluble flavone synthase allows the biosynthesis of phytoestrogen derivatives in Escherichia coli. Applied Microbiology and Biotechnology. 70: 85-91. PMID 16025328 DOI: 10.1007/S00253-005-0059-X  0.724
2005 Yan Y, Chemler J, Huang L, Martens S, Koffas MA. Metabolic engineering of anthocyanin biosynthesis in Escherichia coli. Applied and Environmental Microbiology. 71: 3617-23. PMID 16000769 DOI: 10.1128/Aem.71.7.3617-3623.2005  0.718
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