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Alexandra R. Grassian, Ph.D. - Publications

Affiliations: 
2011 Harvard University, Cambridge, MA, United States 
Area:
Cell Biology, Oncology
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21 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Thomenius MJ, Totman J, Harvey D, Mitchell LH, Riera TV, Cosmopoulos K, Grassian AR, Klaus C, Foley M, Admirand EA, Jahic H, Majer C, Wigle T, Jacques SL, Gureasko J, et al. Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation. Plos One. 13: e0197372. PMID 29856759 DOI: 10.1371/Journal.Pone.0197372  0.387
2017 Chan-Penebre E, Armstrong K, Drew A, Grassian AR, Feldman I, Knutson SK, Kuplast-Barr K, Roche M, Campbell J, Ho P, Copeland RA, Chesworth R, Smith JJ, Keilhack H, Ribich SA. Selective killing of SMARCA2- and SMARCA4-deficient small cell carcinoma of the ovary, hypercalcemic type cells by inhibition of EZH2: In vitro and in vivo preclinical models. Molecular Cancer Therapeutics. PMID 28292935 DOI: 10.1158/1535-7163.Mct-16-0678  0.447
2017 Grassian AR, Harvey D, Fowler J, Drew AE, Feldman I, Chesworth R, Copeland R, Smith JJ, Ribich S. Abstract 406: CRISPR pooled screening of hundreds of cancer cell lines identifies differential dependencies on epigenetic pathways and synthetic lethal relationships Cancer Research. 77: 406-406. DOI: 10.1158/1538-7445.Am2017-406  0.425
2016 Kawano S, Grassian AR, Tsuda M, Knutson SK, Warholic NM, Kuznetsov G, Xu S, Xiao Y, Pollock RM, Smith JS, Kuntz KK, Ribich S, Minoshima Y, Matsui J, Copeland RA, et al. Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma. Plos One. 11: e0158888. PMID 27391784 DOI: 10.1371/Journal.Pone.0158888  0.443
2015 Grassian AR, Scales TM, Knutson SK, Kuntz KW, McCarthy NJ, Lowe CE, Moore JD, Copeland RA, Keilhack H, Smith JJ, Wickenden JA, Ribich S. A Medium-Throughput Single Cell CRISPR-Cas9 Assay to Assess Gene Essentiality. Biological Procedures Online. 17: 15. PMID 26578851 DOI: 10.1186/S12575-015-0028-4  0.447
2015 Grassian AR, Scales T, Knutson SK, McCarthy NJ, Lowe CE, Moore JD, Copeland RA, Keilhack H, Smith JJ, Wickendon JA, Ribich S. Abstract C162: A medium-throughput single cell CRISPR-Cas9 assay to assess gene essentiality Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-C162  0.428
2015 Grassian AR, Fowler J, Feldman I, Riera T, Harvey D, Drew AE, Chesworth R, Copeland RA, Keilhack H, Smith JJ, Ribich S. Abstract B78: CRISPR pooled screening identifies differential dependencies on epigenetic pathways Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-B78  0.408
2014 Grassian AR, Parker SJ, Davidson SM, Divakaruni AS, Green CR, Zhang X, Slocum KL, Pu M, Lin F, Vickers C, Joud-Caldwell C, Chung F, Yin H, Handly ED, Straub C, et al. IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism. Cancer Research. 74: 3317-31. PMID 24755473 DOI: 10.1158/0008-5472.Can-14-0772-T  0.495
2014 Grassian AR, Pagliarini R, Chiang DY. Mutations of isocitrate dehydrogenase 1 and 2 in intrahepatic cholangiocarcinoma. Current Opinion in Gastroenterology. 30: 295-302. PMID 24569570 DOI: 10.1097/Mog.0000000000000050  0.302
2014 Grassian AR, Parker S, Davidson S, Divakaruni A, Green C, Zhang X, Slocum K, Pu M, Lin F, Vickers C, Joud-Caldwell C, Chung F, Yin H, Handly E, Straub C, et al. Abstract LB-139: IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-139  0.5
2013 Grassian AR, Parker S, Davidson S, Green C, Lin F, Joud-Caldwell C, Yin H, Chung F, Straub C, Heiden MV, Pagliarini R, Metallo C. Abstract B159: Heterozygous IDH1 mutations modify the citric acid (TCA) cycle metabolism and sensitize cells to inhibition of mitochondrial respiration/oxidative phosphorylation. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-B159  0.509
2012 Grassian AR, Lin F, Barrett R, Liu Y, Jiang W, Korpal M, Astley H, Gitterman D, Henley T, Howes R, Levell J, Korn JM, Pagliarini R. Isocitrate dehydrogenase (IDH) mutations promote a reversible ZEB1/microRNA (miR)-200-dependent epithelial-mesenchymal transition (EMT). The Journal of Biological Chemistry. 287: 42180-94. PMID 23038259 DOI: 10.1074/Jbc.M112.417832  0.403
2012 Locasale JW, Grassian A, Beroukhim R, Meyerson M, Wagner G, Asara JM, Brugge JS, Vander Heiden MG, Cantley LC. Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S3-O15  0.652
2011 Grassian AR, Coloff JL, Brugge JS. Extracellular matrix regulation of metabolism and implications for tumorigenesis. Cold Spring Harbor Symposia On Quantitative Biology. 76: 313-24. PMID 22105806 DOI: 10.1101/Sqb.2011.76.010967  0.671
2011 Grassian AR, Metallo CM, Coloff JL, Stephanopoulos G, Brugge JS. Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. Genes & Development. 25: 1716-33. PMID 21852536 DOI: 10.1101/Gad.16771811  0.675
2011 Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nature Genetics. 43: 869-74. PMID 21804546 DOI: 10.1038/Ng.890  0.641
2011 Grassian AR, Schafer ZT, Brugge JS. ErbB2 stabilizes epidermal growth factor receptor (EGFR) expression via Erk and Sprouty2 in extracellular matrix-detached cells. The Journal of Biological Chemistry. 286: 79-90. PMID 20956544 DOI: 10.1074/Jbc.M110.169821  0.64
2011 Grassian AR, Metallo CM, Stephanopoulos G, Brugge JS. Abstract 2802: Evaluation of metabolic changes induced by loss of extracellular matrix attachment using 13C Flux analysis Cancer Research. 71: 2802-2802. DOI: 10.1158/1538-7445.Am2011-2802  0.662
2009 Schafer ZT, Grassian AR, Song L, Jiang Z, Gerhart-Hines Z, Irie HY, Gao S, Puigserver P, Brugge JS. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature. 461: 109-13. PMID 19693011 DOI: 10.1038/Nature08268  0.661
2009 Jagani Z, Song K, Kutok JL, Dewar MR, Melet A, Santos T, Grassian A, Ghaffari S, Wu C, Yeckes-Rodin H, Rodin HY, Ren R, Miller K, Khosravi-Far R. Proteasome inhibition causes regression of leukemia and abrogates BCR-ABL-induced evasion of apoptosis in part through regulation of forkhead tumor suppressors. Cancer Research. 69: 6546-55. PMID 19654305 DOI: 10.1158/0008-5472.Can-09-0605  0.399
2008 Melet A, Song K, Bucur O, Jagani Z, Grassian AR, Khosravi-Far R. Apoptotic pathways in tumor progression and therapy. Advances in Experimental Medicine and Biology. 615: 47-79. PMID 18437891 DOI: 10.1007/978-1-4020-6554-5_4  0.404
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