Patrick J. Casey - Publications

Affiliations: 
Duke University, Durham, NC 
Area:
Pharmacology, Genetics, Biostatistics Biology

168 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Lim WK, Chai X, Ghosh S, Ray D, Wang M, Rasheed SAK, Casey PJ. G alpha-13 induces C-X-C motif chemokine ligand 5 expression in prostate cancer cells by transactivating NF-κB. The Journal of Biological Chemistry. PMID 31636124 DOI: 10.1074/jbc.RA119.010018  0.4
2019 Manu KA, Cao PHA, Chai TF, Casey PJ, Wang M. p21cip1/waf1 Coordinate Autophagy, Proliferation and Apoptosis in Response to Metabolic Stress. Cancers. 11. PMID 31382612 DOI: 10.3390/cancers11081112  0.4
2019 Teh JT, Zhu WL, Newgard CB, Casey PJ, Wang M. Respiratory Capacity and Reserve Predict Cell Sensitivity to Mitochondria Inhibitors: Mechanism-Based Markers to Identify Metformin-Responsive Cancers. Molecular Cancer Therapeutics. 18: 693-705. PMID 30824582 DOI: 10.1158/1535-7163.MCT-18-0766  0.4
2017 Rasheed SAK, Leong HS, Lakshmanan M, Raju A, Dadlani D, Chong FT, Shannon NB, Rajarethinam R, Skanthakumar T, Tan EY, Hwang JSG, Lim KH, Tan DS, Ceppi P, Wang M, ... ... Casey PJ, et al. GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers. Oncogene. PMID 29255247 DOI: 10.1038/s41388-017-0038-6  0.4
2017 Manu KA, Chai TF, Teh JT, Zhu WL, Casey PJ, Wang M. Inhibition of Isoprenylcysteine carboxylmethyltransferase induces cell cycle arrest and apoptosis through p21 and p21-regulated BNIP3 induction in pancreatic cancer. Molecular Cancer Therapeutics. PMID 28167504 DOI: 10.1158/1535-7163.MCT-16-0703  0.4
2017 Ng MY, Wang M, Casey PJ, Gan YH, Hagen T. Activation of MAPK/ERK signaling by Burkholderia pseudomallei cycle inhibiting factor (Cif). Plos One. 12: e0171464. PMID 28166272 DOI: 10.1371/journal.pone.0171464  0.4
2016 Wang M, Casey PJ. Protein prenylation: unique fats make their mark on biology. Nature Reviews. Molecular Cell Biology. PMID 26790532 DOI: 10.1038/nrm.2015.11  0.4
2015 Sun WT, Xiang W, Ng BL, Asari K, Bunte RM, Casey PJ, Wang M, Chuah C. Inhibition of isoprenylcysteine carboxylmethyltransferase augments BCR-ABL1 tyrosine kinase inhibition-induced apoptosis in chronic myeloid leukaemia. Experimental Hematology. PMID 26706195 DOI: 10.1016/j.exphem.2015.12.002  0.4
2014 Chia CY, Kumari U, Casey PJ. Breast cancer cell invasion mediated by Gα12 signaling involves expression of interleukins-6 and -8, and matrix metalloproteinase-2. Journal of Molecular Signaling. 9: 6. PMID 24976858 DOI: 10.1186/1750-2187-9-6  0.96
2014 Lau HY, Ramanujulu PM, Guo D, Yang T, Wirawan M, Casey PJ, Go ML, Wang M. An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo. Cancer Biology & Therapy. 15: 1280-91. PMID 24971579 DOI: 10.4161/cbt.29692  0.4
2014 Kimple ME, Neuman JC, Linnemann AK, Casey PJ. Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes. Experimental & Molecular Medicine. 46: e102. PMID 24946790 DOI: 10.1038/emm.2014.40  0.96
2014 Hultman R, Kumari U, Michel N, Casey PJ. Gαz regulates BDNF-induction of axon growth in cortical neurons. Molecular and Cellular Neurosciences. 58: 53-61. PMID 24321455 DOI: 10.1016/j.mcn.2013.12.004  0.96
2013 Cushman I, Cushman SM, Potter PM, Casey PJ. Control of RhoA methylation by carboxylesterase I. The Journal of Biological Chemistry. 288: 19177-83. PMID 23658012 DOI: 10.1074/jbc.M113.467407  0.96
2013 Ramanujulu PM, Yang T, Yap SQ, Wong FC, Casey PJ, Wang M, Go ML. Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt). European Journal of Medicinal Chemistry. 63: 378-86. PMID 23514631 DOI: 10.1016/j.ejmech.2013.02.007  0.96
2013 Rasheed SA, Teo CR, Beillard EJ, Voorhoeve PM, Casey PJ. MicroRNA-182 and microRNA-200a control G-protein subunit α-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells. The Journal of Biological Chemistry. 288: 7986-95. PMID 23329838 DOI: 10.1074/jbc.M112.437749  0.96
2013 Zhu Y, Casey PJ, Kumar AP, Pervaiz S. Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: Evidence for non-canonical activation of RhoA and Rac1 GTPases Cell Death and Disease. 4. DOI: 10.1038/cddis.2013.103  0.96
2012 Kimple ME, Moss JB, Brar HK, Rosa TC, Truchan NA, Pasker RL, Newgard CB, Casey PJ. Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass. The Journal of Biological Chemistry. 287: 20344-55. PMID 22457354 DOI: 10.1074/jbc.M112.359745  0.96
2011 Juneja J, Cushman I, Casey PJ. G12 signaling through c-Jun NH2-terminal kinase promotes breast cancer cell invasion. Plos One. 6: e26085. PMID 22087220 DOI: 10.1371/journal.pone.0026085  0.96
2011 Zhu WL, Hossain MS, Guo DY, Liu S, Tong H, Khakpoor A, Casey PJ, Wang M. A role for Rac3 GTPase in the regulation of autophagy. The Journal of Biological Chemistry. 286: 35291-8. PMID 21852230 DOI: 10.1074/jbc.M111.280990  0.4
2011 Dasgupta S, Cushman I, Kpetemey M, Casey PJ, Vishwanatha JK. Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis. The Journal of Biological Chemistry. 286: 25935-46. PMID 21628459 DOI: 10.1074/jbc.M111.254599  0.96
2011 Forrester MT, Hess DT, Thompson JW, Hultman R, Moseley MA, Stamler JS, Casey PJ. Site-specific analysis of protein S-acylation by resin-assisted capture. Journal of Lipid Research. 52: 393-8. PMID 21044946 DOI: 10.1194/jlr.D011106  0.96
2011 Cushman I, Casey PJ. RHO methylation matters: a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion. Cell Adhesion & Migration. 5: 11-5. PMID 20798596 DOI: 10.4161/cam.5.1.13196  0.96
2011 Hightower KE, Casey PJ. The Enzymology of CAAX Protein Prenylation Enzymes. 30: 1-11. DOI: 10.1016/B978-0-12-415922-8.00001-X  0.96
2010 Go ML, Leow JL, Gorla SK, Schüller AP, Wang M, Casey PJ. Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase Journal of Medicinal Chemistry. 53: 6838-6850. PMID 20809634 DOI: 10.1021/jm1002843  0.96
2010 Wang M, Hossain MS, Tan W, Coolman B, Zhou J, Liu S, Casey PJ. Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth Oncogene. 29: 4959-4970. PMID 20622895 DOI: 10.1038/onc.2010.247  0.96
2010 Mizrahi A, Berdichevsky Y, Casey PJ, Pick E. A prenylated p47phox-p67phox-Rac1 chimera is a Quintessential NADPH oxidase activator: membrane association and functional capacity. The Journal of Biological Chemistry. 285: 25485-99. PMID 20529851 DOI: 10.1074/jbc.M110.113779  0.96
2010 Kelly P, Bailey CL, Fueger PT, Newgard CB, Casey PJ, Kimple ME. Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation. The Journal of Biological Chemistry. 285: 15777-85. PMID 20339002 DOI: 10.1074/jbc.M109.069112  0.96
2010 Doughty-Shenton D, Joseph JD, Zhang J, Pagliarini DJ, Kim Y, Lu D, Dixon JE, Casey PJ. Pharmacological targeting of the mitochondrial phosphatase PTPMT1. The Journal of Pharmacology and Experimental Therapeutics. 333: 584-92. PMID 20167843 DOI: 10.1124/jpet.109.163329  0.96
2010 Kimple ME, Hultman RC, Casey PJ. Signaling through Gz Handbook of Cell Signaling, 2/E. 2: 1649-1653. DOI: 10.1016/B978-0-12-374145-5.00202-3  0.96
2009 Cushman I, Casey PJ. Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration. The Journal of Biological Chemistry. 284: 27964-73. PMID 19651782 DOI: 10.1074/jbc.M109.025296  0.96
2009 Peterson YK, Wang XS, Casey PJ, Tropsha A. Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation. Journal of Medicinal Chemistry. 52: 4210-20. PMID 19537691 DOI: 10.1021/jm8013772  0.96
2009 Rossol-Allison J, Stemmle LN, Swenson-Fields KI, Kelly P, Fields PE, McCall SJ, Casey PJ, Fields TA. Rho GTPase activity modulates Wnt3a/beta-catenin signaling. Cellular Signalling. 21: 1559-68. PMID 19482078 DOI: 10.1016/j.cellsig.2009.05.010  0.96
2009 Bailey CL, Kelly P, Casey PJ. Activation of Rap1 promotes prostate cancer metastasis. Cancer Research. 69: 4962-8. PMID 19470770 DOI: 10.1158/0008-5472.CAN-08-4269  0.96
2009 Juneja J, Casey PJ. Role of G12 proteins in oncogenesis and metastasis. British Journal of Pharmacology. 158: 32-40. PMID 19422395 DOI: 10.1111/j.1476-5381.2009.00180.x  0.96
2009 Wright LP, Court H, Mor A, Ahearn IM, Casey PJ, Philips MR. Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. Molecular and Cellular Biology. 29: 1826-33. PMID 19158273 DOI: 10.1128/MCB.01719-08  0.96
2008 Katadae M, Hagiwara K, Wada A, Ito M, Umeda M, Casey PJ, Fukada Y. Interacting targets of the farnesyl of transducin gamma-subunit. Biochemistry. 47: 8424-33. PMID 18636747 DOI: 10.1021/bi800359h  0.96
2008 Wang M, Tan W, Zhou J, Leow J, Go M, How SL, Casey PJ. A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells Journal of Biological Chemistry. 283: 18678-18684. PMID 18434300 DOI: 10.1074/jbc.M801855200  0.96
2008 Rao PV, Peterson YK, Inoue T, Casey PJ. Effects of pharmacologic inhibition of protein geranylgeranyltransferase type I on aqueous humor outflow through the trabecular meshwork. Investigative Ophthalmology & Visual Science. 49: 2464-71. PMID 18316706 DOI: 10.1167/iovs.07-1639  0.96
2008 Kimple ME, Joseph JW, Bailey CL, Fueger PT, Hendry IA, Newgard CB, Casey PJ. Galphaz negatively regulates insulin secretion and glucose clearance. The Journal of Biological Chemistry. 283: 4560-7. PMID 18096703 DOI: 10.1074/jbc.M706481200  0.96
2008 Bahmanyar S, Kaplan DD, Deluca JG, Giddings TH, O'Toole ET, Winey M, Salmon ED, Casey PJ, Nelson WJ, Barth AI. beta-Catenin is a Nek2 substrate involved in centrosome separation. Genes & Development. 22: 91-105. PMID 18086858 DOI: 10.1101/gad.1596308  0.96
2007 Kelly P, Casey PJ, Meigs TE. Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis. Biochemistry. 46: 6677-87. PMID 17503779 DOI: 10.1021/bi700235f  0.96
2007 Sjogren AK, Andersson KM, Liu M, Cutts BA, Karlsson C, Wahlstrom AM, Dalin M, Weinbaum C, Casey PJ, Tarkowski A, Swolin B, Young SG, Bergo MO. GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer. The Journal of Clinical Investigation. 117: 1294-304. PMID 17476360 DOI: 10.1172/JCI30868  0.84
2007 Baron RA, Peterson YK, Otto JC, Rudolph J, Casey PJ. Time-dependent inhibition of isoprenylcysteine carboxyl methyltransferase by indole-based small molecules. Biochemistry. 46: 554-60. PMID 17209565 DOI: 10.1021/bi060344n  0.96
2007 Leow JL, Baron R, Casey PJ, Go ML. Quantitative structure-activity relationship (QSAR) of indoloacetamides as inhibitors of human isoprenylcysteine carboxyl methyltransferase Bioorganic and Medicinal Chemistry Letters. 17: 1025-1032. PMID 17157012 DOI: 10.1016/j.bmcl.2006.11.030  0.96
2006 Terry KL, Casey PJ, Beese LS. Conversion of protein farnesyltransferase to a geranylgeranyltransferase. Biochemistry. 45: 9746-55. PMID 16893176 DOI: 10.1021/bi060295e  0.96
2006 Stemmle LN, Fields TA, Casey PJ. The regulator of G protein signaling domain of axin selectively interacts with Galpha12 but not Galpha13. Molecular Pharmacology. 70: 1461-8. PMID 16868183 DOI: 10.1124/mol.106.023705  0.96
2006 Kelly P, Stemmle LN, Madden JF, Fields TA, Daaka Y, Casey PJ. A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion. The Journal of Biological Chemistry. 281: 26483-90. PMID 16787920 DOI: 10.1074/jbc.M604376200  0.96
2006 Svensson AW, Casey PJ, Young SG, Bergo MO. Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function. Methods in Enzymology. 407: 144-59. PMID 16757321 DOI: 10.1016/S0076-6879(05)07013-8  0.96
2006 Kelly P, Moeller BJ, Juneja J, Booden MA, Der CJ, Daaka Y, Dewhirst MW, Fields TA, Casey PJ. The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. Proceedings of the National Academy of Sciences of the United States of America. 103: 8173-8. PMID 16705036 DOI: 10.1073/pnas.0510254103  0.96
2006 Peterson YK, Kelly P, Weinbaum CA, Casey PJ. A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity. The Journal of Biological Chemistry. 281: 12445-50. PMID 16517596 DOI: 10.1074/jbc.M600168200  0.96
2006 Wang M, Casey PJ. Isoprenylcysteine carboxylmethyltransferase as a target for development of novel cancer therapeutics Drugs of the Future. 31: 437-445. DOI: 10.1358/dof.2006.031.05.994707  0.96
2005 Kimple ME, Nixon AB, Kelly P, Bailey CL, Young KH, Fields TA, Casey PJ. A role for G(z) in pancreatic islet beta-cell biology. The Journal of Biological Chemistry. 280: 31708-13. PMID 16157560 DOI: 10.1074/jbc.M506700200  0.96
2005 Pagliarini DJ, Wiley SE, Kimple ME, Dixon JR, Kelly P, Worby CA, Casey PJ, Dixon JE. Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. Molecular Cell. 19: 197-207. PMID 16039589 DOI: 10.1016/j.molcel.2005.06.008  0.96
2005 Winter-Vann AM, Casey PJ. Post-prenylation-processing enzymes as new targets in oncogenesis. Nature Reviews. Cancer. 5: 405-12. PMID 15864282 DOI: 10.1038/nrc1612  0.96
2005 Mijimolle N, Velasco J, Dubus P, Guerra C, Weinbaum CA, Casey PJ, Campuzano V, Barbacid M. Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. Cancer Cell. 7: 313-24. PMID 15837621 DOI: 10.1016/j.ccr.2005.03.004  0.96
2005 Winter-Vann AM, Baron RA, Wong W, dela Cruz J, York JD, Gooden DM, Bergo MO, Young SG, Toone EJ, Casey PJ. A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 4336-41. PMID 15784746 DOI: 10.1073/pnas.0408107102  0.96
2005 Meigs TE, Juneja J, DeMarco CT, Stemmle LN, Kaplan DD, Casey PJ. Selective uncoupling of G alpha 12 from Rho-mediated signaling. The Journal of Biological Chemistry. 280: 18049-55. PMID 15746095 DOI: 10.1074/jbc.M500445200  0.96
2005 Clancy SM, Fowler CE, Finley M, Suen KF, Arrabit C, Berton F, Kosaza T, Casey PJ, Slesinger PA. Pertussis-toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex. Molecular and Cellular Neurosciences. 28: 375-89. PMID 15691717 DOI: 10.1016/j.mcn.2004.10.009  0.96
2005 Wittchen ES, Worthylake RA, Kelly P, Casey PJ, Quilliam LA, Burridge K. Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function. The Journal of Biological Chemistry. 280: 11675-82. PMID 15661741 DOI: 10.1074/jbc.M412595200  0.96
2004 Baron RA, Casey PJ. Analysis of the kinetic mechanism of recombinant human isoprenylcysteine carboxylmethyltransferase (Icmt). Bmc Biochemistry. 5: 19. PMID 15625008 DOI: 10.1186/1471-2091-5-19  0.96
2004 Nixon AB, Casey PJ. Analysis of the regulation of microtubule dynamics by interaction of RGSZ1 (RGS20) with the neuronal stathmin, SCG10. Methods in Enzymology. 390: 53-64. PMID 15488170 DOI: 10.1016/S0076-6879(04)90004-3  0.96
2004 Reid TS, Terry KL, Casey PJ, Beese LS. Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. Journal of Molecular Biology. 343: 417-33. PMID 15451670 DOI: 10.1016/j.jmb.2004.08.056  0.96
2004 Embry AC, Glick JL, Linder ME, Casey PJ. Reciprocal signaling between the transcriptional co-factor Eya2 and specific members of the Galphai family. Molecular Pharmacology. 66: 1325-31. PMID 15308761 DOI: 10.1124/mol.104.004093  0.96
2004 Park JG, Langenwalter KJ, Weinbaum CA, Casey PJ, Pang YP. Improved loading and cleavage methods for solid-phase synthesis using chlorotrityl resins: synthesis and testing of a library of 144 discrete chemicals as potential farnesyltransferase inhibitors. Journal of Combinatorial Chemistry. 6: 407-13. PMID 15132601 DOI: 10.1021/cc0340729  0.96
2004 Bergo MO, Gavino BJ, Hong C, Beigneux AP, McMahon M, Casey PJ, Young SG. Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. The Journal of Clinical Investigation. 113: 539-50. PMID 14966563 DOI: 10.1172/JCI18829  0.96
2004 Kaplan DD, Meigs TE, Kelly P, Casey PJ. Identification of a role for beta-catenin in the establishment of a bipolar mitotic spindle. The Journal of Biological Chemistry. 279: 10829-32. PMID 14744872 DOI: 10.1074/jbc.C400035200  0.96
2004 Hagiwara K, Wada A, Katadae M, Ito M, Ohya Y, Casey PJ, Fukada Y. Analysis of the molecular interaction of the farnesyl moiety of transducin through the use of a photoreactive farnesyl analogue. Biochemistry. 43: 300-9. PMID 14717583 DOI: 10.1021/bi0351514  0.96
2004 Bergo MO, Lieu HD, Gavino BJ, Ambroziak P, Otto JC, Casey PJ, Walker QM, Young SG. On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy. The Journal of Biological Chemistry. 279: 4729-36. PMID 14625273 DOI: 10.1074/jbc.M310081200  0.84
2003 Taylor JS, Reid TS, Terry KL, Casey PJ, Beese LS. Structure of mammalian protein geranylgeranyltransferase type-I. The Embo Journal. 22: 5963-74. PMID 14609943 DOI: 10.1093/emboj/cdg571  0.96
2003 Pickett JS, Bowers KE, Hartman HL, Fu HW, Embry AC, Casey PJ, Fierke CA. Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation. Biochemistry. 42: 9741-8. PMID 12911316 DOI: 10.1021/bi0346852  0.96
2003 Fiordalisi JJ, Johnson RL, Weinbaum CA, Sakabe K, Chen Z, Casey PJ, Cox AD. High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors. The Journal of Biological Chemistry. 278: 41718-27. PMID 12882980 DOI: 10.1074/jbc.M305733200  0.6
2003 Winter-Vann AM, Kamen BA, Bergo MO, Young SG, Melnyk S, James SJ, Casey PJ. Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate. Proceedings of the National Academy of Sciences of the United States of America. 100: 6529-34. PMID 12750467 DOI: 10.1073/pnas.1135239100  0.96
2003 Meng J, Casey PJ. Signaling Through G<inf>z</inf> Handbook of Cell Signaling. 2: 601-604. DOI: 10.1016/B978-012124546-7/50580-5  0.96
2002 Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, ... ... Casey PJ, et al. Overview of the Alliance for Cellular Signaling. Nature. 420: 703-6. PMID 12478301 DOI: 10.1038/nature01304  0.96
2002 Long SB, Casey PJ, Beese LS. Reaction path of protein farnesyltransferase at atomic resolution. Nature. 419: 645-50. PMID 12374986 DOI: 10.1038/nature00986  0.96
2002 Meng J, Casey PJ. Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells. The Journal of Biological Chemistry. 277: 43417-24. PMID 12198116 DOI: 10.1074/jbc.M204074200  0.96
2002 Digits JA, Pyun HJ, Coates RM, Casey PJ. Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase. The Journal of Biological Chemistry. 277: 41086-93. PMID 12186880 DOI: 10.1074/jbc.M208069200  0.96
2002 Beigneux A, Withycombe SK, Digits JA, Tschantz WR, Weinbaum CA, Griffey SM, Bergo M, Casey PJ, Young SG. Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver. The Journal of Biological Chemistry. 277: 38358-63. PMID 12151402 DOI: 10.1074/jbc.M205183200  0.96
2002 Meigs TE, Fedor-Chaiken M, Kaplan DD, Brackenbury R, Casey PJ. Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin. The Journal of Biological Chemistry. 277: 24594-600. PMID 11976333 DOI: 10.1074/jbc.M201984200  0.96
2002 Nixon AB, Grenningloh G, Casey PJ. The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly. The Journal of Biological Chemistry. 277: 18127-33. PMID 11882662 DOI: 10.1074/jbc.M201065200  0.96
2002 Bergo MO, Ambroziak P, Gregory C, George A, Otto JC, Kim E, Nagase H, Casey PJ, Balmain A, Young SG. Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation. Molecular and Cellular Biology. 22: 171-81. PMID 11739732 DOI: 10.1128/MCB.22.1.171-181.2002  0.96
2002 Hurwitz HI, Casey PJ. Prenylation of CaaX-type proteins: Basic principles through clinical applications Current Topics in Membranes. 52: 531-550.  0.96
2001 Hightower KE, De S, Weinbaum C, Spence RA, Casey PJ. Lysine 164 α of protein farnesyltransferase is important for both CaaX substrate binding and catalysis Biochemical Journal. 360: 625-631. PMID 11736652 DOI: 10.1042/0264-6021:3600625  0.96
2001 Kaplan DD, Meigs TE, Casey PJ. Distinct Regions of the Cadherin Cytoplasmic Domain Are Essential for Functional Interaction with Gα12 and β-Catenin Journal of Biological Chemistry. 276: 44037-44043. PMID 11546809 DOI: 10.1074/jbc.M106121200  0.96
2001 Burgon PG, Lee WL, Nixon AB, Peralta EG, Casey PJ. Phosphorylation and Nuclear Translocation of a Regulator of G Protein Signaling (RGS10) Journal of Biological Chemistry. 276: 32828-32834. PMID 11443111 DOI: 10.1074/jbc.M100960200  0.96
2001 Schlitzer M, Winter-Vann A, Casey PJ. Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1 Bioorganic and Medicinal Chemistry Letters. 11: 425-427. PMID 11212127 DOI: 10.1016/S0960-894X(00)00685-5  0.96
2001 Hightower KE, Casey PJ, Fierke CA. Farnesylation of nonpeptidic thiol compounds by protein farnesyltransferase. Biochemistry. 40: 1002-10. PMID 11170422 DOI: 10.1021/bi002237d  0.96
2001 Meigs TE, Fields TA, McKee DD, Casey PJ. Interaction of Gα12 and Gα13 with the cytoplasmic domain of cadherin provides a mechanism for β-catenin release Proceedings of the National Academy of Sciences of the United States of America. 98: 519-524. PMID 11136230 DOI: 10.1073/pnas.021350998  0.96
2001 Tschantz WR, Digits JA, Pyun HJ, Coates RM, Casey PJ. Lysosomal prenylcysteine lyase is a FAD-dependent thioether oxidase. The Journal of Biological Chemistry. 276: 2321-4. PMID 11078725 DOI: 10.1074/jbc.C000616200  0.96
2001 Spence RA, Casey PJ. 1 Mechanism of catalysis by protein farnesyltransferase Enzymes. 21: 1-18. DOI: 10.1016/S1874-6047(01)80014-7  0.96
2000 Spence RA, Hightower KE, Terry KL, Beese LS, Fierke CA, Casey PJ. Conversion of Tyr361 beta to Leu in mammalian protein farnesyltransferase impairs product release but not substrate recognition. Biochemistry. 39: 13651-9. PMID 11076503 DOI: 10.1021/bi001084r  0.96
2000 Chen Z, Otto JC, Bergo MO, Young SG, Casey PJ. The C-terminal polylysine region and methylation of K-Ras are critical for the interaction between K-Ras and microtubules. The Journal of Biological Chemistry. 275: 41251-7. PMID 11007785 DOI: 10.1074/jbc.M006687200  0.96
2000 Bergo MO, Leung GK, Ambroziak P, Otto JC, Casey PJ, Young SG. Targeted inactivation of the isoprenyleysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells Journal of Biological Chemistry. 275: 17605-17610. PMID 10747846 DOI: 10.1074/jbc.C000079200  0.96
2000 Long SB, Casey PJ, Beese LS. The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures. Structure (London, England : 1993). 8: 209-22. PMID 10673434 DOI: 10.1016/S0969-2126(00)00096-4  0.96
1999 Meng J, Glick JL, Polakis P, Casey PJ. Functional interaction between Galpha(z) and Rap1GAP suggests a novel form of cellular cross-talk. The Journal of Biological Chemistry. 274: 36663-9. PMID 10593970 DOI: 10.1074/jbc.274.51.36663  0.96
1999 Tschantz WR, Zhang L, Casey PJ. Cloning, expression, and cellular localization of a human prenylcysteine lyase Journal of Biological Chemistry. 274: 35802-35808. PMID 10585463 DOI: 10.1074/jbc.274.50.35802  0.96
1999 Fu HW, Casey PJ. Enzymology and biology of CaaX protein prenylation Recent Progress in Hormone Research. 54: 315-343. PMID 10548882  0.96
1999 Otto JC, Kim E, Young SG, Casey PJ. Cloning and characterization of a mammalian prenyl protein-specific protease Journal of Biological Chemistry. 274: 8379-8382. PMID 10085068 DOI: 10.1074/jbc.274.13.8379  0.96
1998 Hightower KE, Huang CC, Casey PJ, Fierke CA. H-Ras peptide and protein substrates bind protein farnesyltransferase as an ionized thiolate. Biochemistry. 37: 15555-62. PMID 9799520 DOI: 10.1021/bi981525v  0.96
1998 Glick JL, Meigs TE, Miron A, Casey PJ. RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha. The Journal of Biological Chemistry. 273: 26008-13. PMID 9748279 DOI: 10.1074/jbc.273.40.26008  0.96
1998 Long SB, Casey PJ, Beese LS. Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate. Biochemistry. 37: 9612-8. PMID 9657673 DOI: 10.1021/bi980708e  0.96
1998 Fu HW, Beese LS, Casey PJ. Kinetic analysis of zinc ligand mutants of mammalian protein farnesyltransferase. Biochemistry. 37: 4465-72. PMID 9521766 DOI: 10.1021/bi972511c  0.96
1997 Hurwitz LM, Casey PJ. Can prenylcysteines be exploited as ligands for mammalian multidrug-resistance transporters? Chemistry and Biology. 4: 711-715. PMID 9375248  0.96
1997 Thissen JA, Gross JM, Subramanian K, Meyer T, Casey PJ. Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking. The Journal of Biological Chemistry. 272: 30362-70. PMID 9374526 DOI: 10.1074/jbc.272.48.30362  0.96
1997 Zhang L, Tschantz WR, Casey PJ. Isolation and characterization of a prenylcysteine lyase from bovine brain Journal of Biological Chemistry. 272: 23354-23359. PMID 9287348 DOI: 10.1074/jbc.272.37.23354  0.96
1997 Lebowitz PF, Casey PJ, Prendergast GC, Thissen JA. Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB. The Journal of Biological Chemistry. 272: 15591-4. PMID 9188444 DOI: 10.1074/jbc.272.25.15591  0.96
1997 Park HW, Boduluri SR, Moomaw JF, Casey PJ, Beese LS. Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution. Science (New York, N.Y.). 275: 1800-4. PMID 9065406 DOI: 10.1126/science.275.5307.1800  0.96
1997 Fields TA, Casey PJ. Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins Biochemical Journal. 321: 561-571. PMID 9032437  0.96
1997 Huang CC, Casey PJ, Fierke CA. Evidence for a catalytic role of zinc in protein farnesyltransferase. Spectroscopy of Co2+-farnesyltransferase indicates metal coordination of the substrate thiolate. The Journal of Biological Chemistry. 272: 20-3. PMID 8995218 DOI: 10.1074/jbc.272.1.20  0.96
1997 Tschantz WR, Furfine ES, Casey PJ. Substrate binding is required for release of product from mammalian protein farnesyltransferase Faseb Journal. 11. DOI: 10.1074/jbc.272.15.9989  0.96
1997 Otto JC, Casey PJ. Analysis of the C-terminal proteolysis of prenylated proteins Faseb Journal. 11.  0.96
1997 Fu HW, Casey PJ. Structure-function analysis of residues important in zinc binding and activity in protein farnes yltransferase Faseb Journal. 11.  0.96
1997 Huang CC, Casey PJ, Fierke CA. Functions of metals in protein farnesyltransferase Faseb Journal. 11: A1307.  0.96
1996 Zhang FL, Casey PJ. Influence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-I Biochemical Journal. 320: 925-932. PMID 9003382  0.96
1996 Higgins JB, Casey PJ. The role of prenylation in G-protein assembly and function Cellular Signalling. 8: 433-437. PMID 8958445 DOI: 10.1016/S0898-6568(96)00071-X  0.96
1996 Thissen JA, Casey PJ. Kinetics of protein farnesyltransferase: Sigmoidal vs hyperbolic behavior as a function of assay conditions Analytical Biochemistry. 243: 80-85. PMID 8954528 DOI: 10.1006/abio.1996.0484  0.96
1996 Fu HW, Moomaw JF, Moomaw CR, Casey PJ. Identification of a cysteine residue essential for activity of protein farnesyltransferase: Cys 299 is exposed only upon removal of zinc from the enzyme Journal of Biological Chemistry. 271: 28541-28548. PMID 8910483 DOI: 10.1074/jbc.271.45.28541  0.96
1996 Zhang FL, Casey PJ. Protein prenylation: Molecular mechanisms and functional consequences Annual Review of Biochemistry. 65: 241-269. PMID 8811180  0.96
1996 Hunt TW, Fields TA, Casey PJ, Peralta EG. RGS10 is a selective activator of Gα(i) GTPase activity Nature. 383: 175-177. PMID 8774883 DOI: 10.1038/383175a0  0.96
1996 Zhang FL, Fu HW, Casey PJ, Bishop WR. Substitution of cadmium for zinc in farnesyl:protein transferase alters its substrate specificity Biochemistry. 35: 8166-8171. PMID 8679569 DOI: 10.1021/bi960574+  0.96
1996 Glick J, Santoyo G, Casey PJ. Arachidonate and related unsaturated fatty acids selectively inactivate the guanine nucleotide-binding regulatory protein, Gz. The Journal of Biological Chemistry. 271: 2949-54. PMID 8621685  0.96
1996 Casey PJ, Seabra MC. Protein prenyltransferases Journal of Biological Chemistry. 271: 5289-5292. PMID 8621375 DOI: 10.1074/jbc.271.10.5289  0.96
1996 Otto JC, Casey PJ. The hepatitis delta virus large antigen is farnesylated both in vitro and in animal cells Journal of Biological Chemistry. 271: 4569-4572. DOI: 10.1074/jbc.271.9.4569  0.96
1996 Higgins JB, Casey PJ. [8] Assays for G protein βγ subunit activity Methods in Neurosciences. 29: 90-100. DOI: 10.1016/S1043-9471(96)80044-9  0.96
1996 Otto JC, Hayward KN, Casey PJ. Prenylation of the hepatitis delta virus large antigen: a new target for farnesyltransferase inhibitors Faseb Journal. 10.  0.96
1995 Casey PJ. Mechanisms of protein prenylation and role in G protein function Biochemical Society Transactions. 23: 161-166. PMID 7758720  0.96
1995 Casey PJ. Protein lipidation in cell signaling Science. 268: 221-225. PMID 7716512  0.96
1995 Thissen JA, Barrett MG, Casey PJ. Prenylated peptides in identification of specific binding proteins Methods in Enzymology. 250: 158-168. PMID 7651148 DOI: 10.1016/0076-6879(95)50070-7  0.96
1995 Moomaw JF, Zhang FL, Casey PJ. Isolation of protein prenyltransferases from bovine brain and baculovirus expression system Methods in Enzymology. 250: 12-21. PMID 7651144 DOI: 10.1016/0076-6879(95)50058-8  0.96
1995 Huang CL, Slesinger PA, Casey PJ, Jan YN, Jan LY. Evidence that direct binding of G beta gamma to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation. Neuron. 15: 1133-43. PMID 7576656 DOI: 10.1016/0896-6273(95)90101-9  0.96
1995 Fields TA, Casey PJ. Phosphorylation of GΖα by protein kinase C blocks interaction with the βγ complex Journal of Biological Chemistry. 270: 23119-23125. PMID 7559455  0.96
1995 Zhang L, Sachs CW, Fu HW, Fine RL, Casey PJ. Characterization of prenylcysteines that interact with P-glycoprotein and inhibit drug transport in tumor cells. The Journal of Biological Chemistry. 270: 22859-65. PMID 7559420 DOI: 10.1074/jbc.270.39.22859  0.96
1995 Casey PJ, Buss JE. Lipid modifications of protein: Preface Methods in Enzymology. 250: xvii-xviii. DOI: 10.1016/0076-6879(95)50055-3  0.96
1994 Thomason PA, James SR, Casey PJ, Downes CP. A G-protein βγ-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol Journal of Biological Chemistry. 269: 16525-16528. PMID 8206965  0.96
1994 Fields TA, Linder ME, Casey PJ. Subtype-specific binding of azidoanilido-GTP by purified G protein α subunits Biochemistry. 33: 6877-6883. PMID 8204622 DOI: 10.1021/bi00188a017  0.96
1994 Casey PJ, Moomaw JP, Zhang FL, Higgins JB, Thissen JA. Prenylation and G protein signaling Recent Progress in Hormone Research. 49: 215-238. PMID 8146425  0.96
1994 Higgins JB, Casey PJ. In Vitro processing of recombinant G protein γ subunits: Requirements for assembly of an active βγ complex Journal of Biological Chemistry. 269: 9067-9073. PMID 8132644  0.96
1994 Zhang FL, Diehl RE, Kohl NE, Gibbs JB, Giros B, Casey PJ, Omer CA. cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I. The Journal of Biological Chemistry. 269: 3175-80. PMID 8106351  0.96
1994 Zhang FL, Moomaw JF, Casey PJ. Properties and kinetic mechanism of recombinant mammalian protein geranylgeranyltransferase type I Journal of Biological Chemistry. 269: 23465-23470. PMID 8089111  0.96
1994 Casey PJ. Lipid modifications of G proteins Current Opinion in Cell Biology. 6: 219-225. PMID 8024813 DOI: 10.1016/0955-0674(94)90139-2  0.96
1994 Zhang L, Sachs CW, Fine RL, Casey PJ. Interaction of prenylcysteine methyl esters with the multidrug resistance transporter. The Journal of Biological Chemistry. 269: 15973-6. PMID 7911465  0.96
1993 Chen WJ, Moomaw JF, Overton L, Kost TA, Casey PJ. High level expression of mammalian protein farnesyltransferase in a baculovirus system: The purified protein contains zinc Journal of Biological Chemistry. 268: 9675-9680. PMID 8486655  0.96
1993 Thissen JA, Casey PJ. Microsomal membranes contain a high affinity binding site for prenylated peptides Journal of Biological Chemistry. 268: 13780-13783. PMID 8314746  0.96
1992 Menard L, Tomhave E, Casey PJ, Uhing RJ, Snyderman R, Didsbury JR. Rac1, a low-molecular-mass GTP-binding-protein with high intrinsic GTPase activity and distinct biochemical properties European Journal of Biochemistry. 206: 537-546. PMID 1597193 DOI: 10.1111/j.1432-1033.1992.tb16957.x  0.96
1992 Caplan AJ, Tsai J, Casey PJ, Douglas MG. Farnesylation of YDJ1p is required for function at elevated growth temperatures in Saccharomyces cerevisiae Journal of Biological Chemistry. 267: 18890-18895. PMID 1527016  0.96
1992 Moomaw JF, Casey PJ. Mammalian protein geranylgeranyltransferase: Subunit composition and metal requirements Journal of Biological Chemistry. 267: 17438-17443. PMID 1512274  0.96
1992 Casey PJ. Biochemistry of protein prenylation. Review Journal of Lipid Research. 33: 1731-1740. PMID 1479283  0.96
1992 Colombo MI, Mayorga LS, Casey PJ, Stahl PD. Evidence of a role for heterotrimeric GTP-binding proteins in endosome fusion Science. 255: 1695-1697. PMID 1348148  0.96
1991 Seabra MC, Reiss Y, Casey PJ, Brown MS, Goldstein JL. Protein farnesyltransferase and geranylgeranyltransferase share a common α subunit Cell. 65: 429-434. PMID 2018975 DOI: 10.1016/0092-8674(91)90460-G  0.96
1991 Lounsbury KM, Casey PJ, Brass LF, Manning DR. Phosphorylation of Gz in human platelets: Selectivity and site of modification Journal of Biological Chemistry. 266: 22051-22056. PMID 1939224  0.96
1991 Casey PJ, Thissen JA, Moomaw JF. Enzymatic modification of proteins with a geranylgeranyl isoprenoid Proceedings of the National Academy of Sciences of the United States of America. 88: 8631-8635. PMID 1924324  0.96
1991 Casey PJ, Pang IH, Gilman AG. Assay of G-protein beta gamma-subunit complex by catalytic support of ADP-ribosylation of Go alpha. Methods in Enzymology. 195: 315-21. PMID 1903494  0.96
1990 Reiss Y, Goldstein JL, Seabra MC, Casey PJ, Brown MS. Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides Cell. 62: 81-88. PMID 2194674 DOI: 10.1016/0092-8674(90)90242-7  0.96
1990 Hinton DR, Blanks JC, Fong HK, Casey PJ, Hildebrandt E, Simons MI. Novel localization of a G protein, Gz-alpha, in neurons of brain and retina. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 2763-70. PMID 2117645  0.96
1990 Mumby SM, Casey PJ, Gilman AG, Gutowski S, Sternweis PC. G protein gamma subunits contain a 20-carbon isoprenoid. Proceedings of the National Academy of Sciences of the United States of America. 87: 5873-7. PMID 2116011  0.96
1990 Casey PJ, Fong HK, Simon MI, Gilman AG. Gz, a guanine nucleotide-binding protein with unique biochemical properties. The Journal of Biological Chemistry. 265: 2383-90. PMID 2105321  0.96
1990 Farnsworth CC, Casey PJ, Howald WN, Glomset JA, Gelb MH. Structural characterization of prenyl groups attached to proteins Methods. 1: 231-240. DOI: 10.1016/S1046-2023(05)80322-6  0.96
1989 Casey PJ, Solski PA, Der CJ, Buss JE. p21ras is modified by a farnesyl isoprenoid. Proceedings of the National Academy of Sciences of the United States of America. 86: 8323-7. PMID 2682646  0.96
1989 Freissmuth M, Casey PJ, Gilman AG. G proteins control diverse pathways of transmembrane signaling Faseb Journal. 3: 2125-2139. PMID 2546847  0.96
1989 Casey PJ, Graziano MP, Gilman AG. G protein beta gamma subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of alpha subunits by pertussis toxin but differential interactions with Gs alpha. Biochemistry. 28: 611-6. PMID 2496748  0.96
1988 Casey PJ, Graziano MP, Freissmuth M, Gilman AG. Role of G proteins in transmembrane signaling. Cold Spring Harbor Symposia On Quantitative Biology. 53: 203-8. PMID 3151167  0.96
1988 Casey PJ, Gilman AG. G protein involvement in receptor-effector coupling Journal of Biological Chemistry. 263: 2577-2580. PMID 2830256  0.96
1987 Casey PJ, Lowenstein JM. Inhibition of adenylosuccinate lyase by L-alanosyl-5-aminoimidazole-4-carboxylic acid ribonucleotide (alanosyl-aicor) Biochemical Pharmacology. 36: 705-709. PMID 3827951 DOI: 10.1016/0006-2952(87)90722-2  0.96
1987 Casey PJ, Lowenstein JM. Purification of adenylosuccinate lyase from rat skeletal muscle by a novel affinity column. Stabilization of the enzyme, and effects of anions and fluoro analogues of the substrate Biochemical Journal. 246: 263-269. PMID 3689310  0.96
1987 Buss JE, Mumby SM, Casey PJ, Gilman AG, Sefton BM. Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins. Proceedings of the National Academy of Sciences of the United States of America. 84: 7493-7. PMID 3118369  0.96
1987 Graziano MP, Casey PJ, Gilman AG. Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase. The Journal of Biological Chemistry. 262: 11375-81. PMID 3112160  0.96
1986 Casey PJ, Abeles RH, Lowenstein JM. Metabolism of threo-beta-fluoroaspartate by H4 cells. Inhibition of adenylosuccinate lyase by fluoro analogs of its substrates. The Journal of Biological Chemistry. 261: 13637-42. PMID 3759987  0.96
1985 Casey PJ, Lowenstein JM. Purification and characterization of adenylosuccinate lyase from rat skeletal muscle Federation Proceedings. 44.  0.96
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