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Derek Dykxhoorn - Publications

Affiliations: 
University of Miami, Coral Gables, FL 
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31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Song E, Lee SK, Dykxhoorn DM, Novina C, Zhang D, Crawford K, Cerny J, Sharp PA, Lieberman J, Manjunath N, Shankar P. Correction for Song et al., "Sustained Small Interfering RNA-Mediated Human Immunodeficiency Virus Type 1 Inhibition in Primary Macrophages". Journal of Virology. e0093623. PMID 37830822 DOI: 10.1128/jvi.00936-23  0.419
2023 Cukier HN, Duarte CL, Laverde-Paz MJ, Simon SA, Van Booven DJ, Miyares AT, Whitehead PL, Hamilton-Nelson KL, Adams LD, Carney RM, Cuccaro ML, Vance JM, Pericak-Vance MA, Griswold AJ, Dykxhoorn DM. An Alzheimer's disease risk variant in TTC3 modifies the actin cytoskeleton organization and the PI3K-Akt signaling pathway in iPSC-derived forebrain neurons. Neurobiology of Aging. 131: 182-195. PMID 37677864 DOI: 10.1016/j.neurobiolaging.2023.07.007  0.361
2023 Cukier HN, Duarte CL, Laverde-Paz MJ, Simon SA, Van Booven DJ, Miyares AT, Whitehead PL, Hamilton-Nelson KL, Adams LD, Carney RM, Cuccaro ML, Vance JM, Pericak-Vance MA, Griswold AJ, Dykxhoorn DM. An Alzheimer's disease risk variant in modifies the actin cytoskeleton organization and the PI3K-Akt signaling pathway in iPSC-derived forebrain neurons. Biorxiv : the Preprint Server For Biology. PMID 37292815 DOI: 10.1101/2023.05.25.542316  0.361
2022 Edwards JS, Delabat SA, Badilla AD, DiCaprio RC, Hyun J, Burgess RA, Silva T, Dykxhoorn DM, Chen SX, Wang L, Ishida Y, Saito T, Thomas E. Downregulation of SOCS1 increases interferon-induced ISGylation during differentiation of induced-pluripotent stem cells to hepatocytes. Jhep Reports : Innovation in Hepatology. 4: 100592. PMID 36439639 DOI: 10.1016/j.jhepr.2022.100592  0.329
2022 Brandenburg C, Griswold AJ, Van Booven DJ, Kilander MBC, Frei JA, Nestor MW, Dykxhoorn DM, Pericak-Vance MA, Blatt GJ. Transcriptomic analysis of isolated and pooled human postmortem cerebellar Purkinje cells in autism spectrum disorders. Frontiers in Genetics. 13: 944837. PMID 36437953 DOI: 10.3389/fgene.2022.944837  0.309
2022 Tang PC, V Roche M, Young Um S, Gosstola NC, Young Kim M, Yoon Choi B, Dykxhoorn DM, Zhong Liu X. Characterization of an induced pluripotent stem cell line (UMi040-A) bearing an auditory neuropathy spectrum disorder-associated variant in TMEM43. Stem Cell Research. 61: 102758. PMID 35364395 DOI: 10.1016/j.scr.2022.102758  0.331
2021 Frei JA, Niescier RF, Bridi MS, Durens M, Nestor JE, Kilander MBC, Yuan X, Dykxhoorn DM, Nestor MW, Huang S, Blatt GJ, Lin YC. Regulation of Neural Circuit Development by Cadherin-11 Provides Implications for Autism. Eneuro. PMID 34135003 DOI: 10.1523/ENEURO.0066-21.2021  0.34
2021 Frei JA, Brandenburg CJ, Nestor JE, Hodzic DM, Plachez C, McNeill H, Dykxhoorn DM, Nestor MW, Blatt GJ, Lin YC. Postnatal expression profiles of atypical cadherin FAT1 suggest its role in autism. Biology Open. 10. PMID 34100899 DOI: 10.1242/bio.056457  0.334
2021 Frei JA, Brandenburg C, Nestor JE, Hodzic DM, Plachez C, McNeill H, Dykxhoorn DM, Nestor MW, Blatt GJ, Lin YC. Postnatal expression profiles of atypical cadherin FAT1 suggest its role in autism. Biology Open. PMID 33983383 DOI: 10.1242/bio.056457  0.334
2019 Hatzistergos KE, Williams AR, Dykxhoorn DM, Bellio MA, Yu W, Hare JM. Tumor Suppressors RB1 and CDKN2a Cooperatively Regulate Cell-Cycle Progression and Differentiation During Cardiomyocyte Development and Repair: Implications for Stimulating Neomyogenesis with Cell-Based Therapy. Circulation Research. PMID 30744497 DOI: 10.1161/Circresaha.118.314063  0.371
2019 Dykxhoorn DM, Cukier HN, Maddy KS, Adams LD, Starks TD, Celis K, Acosta H, Feliciano-Astacio BE, Byrd GS, Cuccaro ML, Beecham GW, Pericak-Vance MA, Vance JM. P3-206: INVESTIGATING ANCESTRY SPECIFIC DIFFERENCES IN APOE FUNCTION USING INDUCED PLURIPOTENT STEM CELLS Alzheimer's & Dementia. 15: P1008-P1009. DOI: 10.1016/J.Jalz.2019.06.3236  0.324
2018 DeRosa BA, El Hokayem J, Artimovich E, Garcia-Serje C, Phillips AW, Van Booven D, Nestor JE, Wang L, Cuccaro ML, Vance JM, Pericak-Vance MA, Cukier HN, Nestor MW, Dykxhoorn DM. Convergent Pathways in Idiopathic Autism Revealed by Time Course Transcriptomic Analysis of Patient-Derived Neurons. Scientific Reports. 8: 8423. PMID 29849033 DOI: 10.1038/S41598-018-26495-1  0.405
2018 Asumda FZ, Hatzistergos KE, Dykxhoorn DM, Jakubski S, Edwards J, Thomas E, Schiff ER. Differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules. Differentiation; Research in Biological Diversity. 101: 16-24. PMID 29626713 DOI: 10.1016/J.Diff.2018.03.002  0.398
2017 Chang KC, Hertz J, Zhang X, Jin XL, Shaw P, Derosa BA, Li JY, Venugopalan P, Valenzuela DA, Patel RD, Russano KR, Alshamekh SA, Sun C, Tenerelli K, Li C, ... ... Dykxhoorn DM, et al. Novel regulatory mechanisms for the SoxC transcriptional network required for visual pathway development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28411269 DOI: 10.1523/Jneurosci.3430-13.2017  0.346
2016 El Hokayem J, Cukier HN, Dykxhoorn DM. Blood Derived Induced Pluripotent Stem Cells (iPSCs): Benefits, Challenges and the Road Ahead. Journal of Alzheimer's Disease & Parkinsonism. 6. PMID 27882265 DOI: 10.4172/2161-0460.1000275  0.363
2016 Belle K, Shabazz FS, Nuytemans K, Davis DA, Ali A, Young JL, Scott WK, Mash DC, Vance JM, Dykxhoorn DM. Generation of disease-specific autopsy-confirmed iPSCs lines from postmortem isolated Peripheral Blood Mononuclear Cells. Neuroscience Letters. PMID 27826014 DOI: 10.1016/J.Neulet.2016.10.065  0.413
2015 Esanov R, Belle KC, van Blitterswijk M, Belzil VV, Rademakers R, Dickson DW, Petrucelli L, Boylan KB, Dykxhoorn DM, Wuu J, Benatar M, Wahlestedt C, Zeier Z. C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells. Experimental Neurology. PMID 26746986 DOI: 10.1016/J.Expneurol.2015.12.022  0.334
2015 DeRosa BA, Belle KC, Thomas BJ, Cukier HN, Pericak-Vance MA, Vance JM, Dykxhoorn DM. hVGAT-mCherry: A novel molecular tool for analysis of GABAergic neurons derived from human pluripotent stem cells. Molecular and Cellular Neurosciences. 68: 244-57. PMID 26284979 DOI: 10.1016/J.Mcn.2015.08.007  0.606
2015 Zeier Z, Esanov R, Belle KC, Volmar CH, Johnstone AL, Halley P, DeRosa BA, Khoury N, van Blitterswijk M, Rademakers R, Albert J, Brothers SP, Wuu J, Dykxhoorn DM, Benatar M, et al. Bromodomain inhibitors regulate the C9ORF72 locus in ALS. Experimental Neurology. 271: 241-50. PMID 26099177 DOI: 10.1016/J.Expneurol.2015.06.017  0.593
2012 DeRosa BA, Van Baaren JM, Dubey GK, Lee JM, Cuccaro ML, Vance JM, Pericak-Vance MA, Dykxhoorn DM. Derivation of autism spectrum disorder-specific induced pluripotent stem cells from peripheral blood mononuclear cells. Neuroscience Letters. 516: 9-14. PMID 22405972 DOI: 10.1016/J.Neulet.2012.02.086  0.606
2012 ALSHAMEKH S, HERTZ J, DEROSA B, UDDIN S, PATEL R, SALERO E, DYKXHOORN D, GOLDBERG J. Generating human retinal ganglion cells from human induced pluripotent cells in feeder and feeder-free conditions Acta Ophthalmologica. 90: 0-0. DOI: 10.1111/J.1755-3768.2012.4476.X  0.364
2009 Wheeler L, Basar E, McKernan S, Dykxhoorn D, Lieberman J. P19-22. CD4-targeted delivery of HIV and CCR5 siRNAs by aptamer-siRNA chimeras suppresses HIV infection in primary cells and in human cervical explants Retrovirology. 6: P342. DOI: 10.1186/1742-4690-6-S3-P342  0.363
2007 Glodek AM, Le Y, Dykxhoorn DM, Park SY, Mostoslavsky G, Mulligan R, Lieberman J, Beggs HE, Honczarenko M, Silberstein LE. Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells Leukemia. 21: 1723-1732. PMID 17568820 DOI: 10.1038/sj.leu.2404769  0.548
2006 Dykxhoorn DM, Lieberman J. Running interference: prospects and obstacles to using small interfering RNAs as small molecule drugs. Annual Review of Biomedical Engineering. 8: 377-402. PMID 16834561 DOI: 10.1146/Annurev.Bioeng.8.061505.095848  0.356
2006 Dykxhoorn DM, Palliser D, Lieberman J. The silent treatment: siRNAs as small molecule drugs. Gene Therapy. 13: 541-52. PMID 16397510 DOI: 10.1038/Sj.Gt.3302703  0.306
2006 Silberstein LE, Dykxhoorn D, Le Y, Honczarenko M, Lieberman J, Glodek A. Focal Adhesion Kinase (FAK) Is Required for CXCL12-Induced Dhemotaxis and Adhesion to VCAM-1 in B Lymphocytes and Hematopoietic Stem/Progenitor Cells. Blood. 108: 1325-1325. DOI: 10.1182/Blood.V108.11.1325.1325  0.335
2005 Dykxhoorn DM, Lieberman J. The silent revolution: RNA interference as basic biology, research tool, and therapeutic. Annual Review of Medicine. 56: 401-23. PMID 15660519 DOI: 10.1146/Annurev.Med.56.082103.104606  0.363
2003 Song E, Lee SK, Dykxhoorn DM, Novina C, Zhang D, Crawford K, Cerny J, Sharp PA, Lieberman J, Manjunath N, Shankar P. Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages. Journal of Virology. 77: 7174-81. PMID 12805416 DOI: 10.1128/Jvi.77.13.7174-7181.2003  0.424
2003 Dykxhoorn DM, Novina CD, Sharp PA. Killing the messenger: short RNAs that silence gene expression. Nature Reviews. Molecular Cell Biology. 4: 457-67. PMID 12778125 DOI: 10.1038/Nrm1129  0.457
2003 Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, Sabatini DM, Chen IS, Hahn WC, Sharp PA, Weinberg RA, Novina CD. Lentivirus-delivered stable gene silencing by RNAi in primary cells. Rna (New York, N.Y.). 9: 493-501. PMID 12649500 DOI: 10.1261/Rna.2192803  0.477
2002 Novina CD, Murray MF, Dykxhoorn DM, Beresford PJ, Riess J, Lee SK, Collman RG, Lieberman J, Shankar P, Sharp PA. siRNA-directed inhibition of HIV-1 infection. Nature Medicine. 8: 681-6. PMID 12042777 DOI: 10.1038/Nm725  0.419
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