| Year |
Citation |
Score |
| 2020 |
Punt A, Bouwmeester H, Blaauboer BJ, Coecke S, Hakkert B, Hendriks DFG, Jennings P, Kramer NI, Neuhoff S, Masereeuw R, Paini A, Peijnenburg AACM, Rooseboom M, Shuler ML, Sorrell I, et al. New approach methodologies (NAMs) for human-relevant biokinetics predictions: Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment. Altex. PMID 32521035 DOI: 10.14573/Altex.2003242 |
0.302 |
|
| 2019 |
McAleer CW, Pointon A, Long CJ, Brighton RL, Wilkin BD, Bridges LR, Narasimhan Sriram N, Fabre K, McDougall R, Muse VP, Mettetal JT, Srivastava A, Williams D, Schnepper MT, Roles JL, ... Shuler ML, et al. On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships. Scientific Reports. 9: 9619. PMID 31270362 DOI: 10.1038/S41598-019-45656-4 |
0.302 |
|
| 2019 |
Sung JH, Wang Y, Shuler ML. Strategies for using mathematical modeling approaches to design and interpret multi-organ microphysiological systems (MPS). Apl Bioengineering. 3: 021501. PMID 31263796 DOI: 10.1063/1.5097675 |
0.472 |
|
| 2019 |
McAleer CW, Long CJ, Elbrecht D, Sasserath T, Bridges LR, Rumsey JW, Martin C, Schnepper M, Wang Y, Schuler F, Roth AB, Funk C, Shuler ML, Hickman JJ. Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics. Science Translational Medicine. 11. PMID 31217335 DOI: 10.1126/Scitranslmed.Aav1386 |
0.343 |
|
| 2019 |
Chen HJ, Shuler ML. Engineering a Bioartificial Human Colon Model Through Decellularization and Recellularization. Methods in Molecular Biology (Clifton, N.J.). 1907: 91-102. PMID 30542993 DOI: 10.1007/978-1-4939-8967-6_7 |
0.303 |
|
| 2019 |
Sung JH, Koo J, Shuler ML. Mimicking the Human Physiology with Microphysiological Systems (MPS) Biochip Journal. 13: 115-126. DOI: 10.1007/S13206-019-3201-Z |
0.522 |
|
| 2018 |
Sung JH, Wang YI, Kim JH, Lee JM, Shuler ML. Application of chemical reaction engineering principles to 'body-on-a-chip' systems. Aiche Journal. American Institute of Chemical Engineers. 64: 4351-4360. PMID 31402795 DOI: 10.1002/Aic.16448 |
0.525 |
|
| 2018 |
Sung JH, Wang Y, Narasimhan Sriram N, Jackson M, Long C, Hickman JJ, Shuler M. Recent advances in body-on-a-chip systems. Analytical Chemistry. PMID 30472828 DOI: 10.1021/Acs.Analchem.8B05293 |
0.492 |
|
| 2018 |
Wang YI, Shuler ML. UniChip enables long-term recirculating unidirectional perfusion with gravity-driven flow for microphysiological systems. Lab On a Chip. PMID 30046784 DOI: 10.1039/C8Lc00394G |
0.332 |
|
| 2018 |
Chen HJ, Miller P, Shuler ML. A pumpless body-on-a-chip model using a primary culture of human intestinal cells and a 3D culture of liver cells. Lab On a Chip. PMID 29881844 DOI: 10.1039/C8Lc00111A |
0.38 |
|
| 2018 |
Pajoumshariati SR, Azizi M, Wesner D, Miller PG, Shuler M, Abbaspourrad A. Microfluidic-Based Cell-Embedded Microgels Using Non-Fluorinated Oil as a Model of the Gastrointestinal Niche. Acs Applied Materials & Interfaces. PMID 29474057 DOI: 10.1021/Acsami.7B16916 |
0.414 |
|
| 2017 |
Wang YI, Carmona C, Hickman JJ, Shuler ML. Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges. Advanced Healthcare Materials. PMID 29205920 DOI: 10.1002/Adhm.201701000 |
0.357 |
|
| 2017 |
Miller PG, Wang YI, Swan G, Shuler ML. A simple cell transport device keeps culture alive and functional during shipping. Biotechnology Progress. PMID 28597974 DOI: 10.1002/Btpr.2512 |
0.355 |
|
| 2016 |
Mahler GJ, Esch MB, Stokol T, Hickman JJ, Shuler ML. Body-on-a-chip systems for animal-free toxicity testing. Alternatives to Laboratory Animals : Atla. 44: 469-478. PMID 27805830 DOI: 10.1177/026119291604400508 |
0.311 |
|
| 2016 |
Wang YI, Abaci HE, Shuler ML. Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening. Biotechnology and Bioengineering. PMID 27399645 DOI: 10.1002/Bit.26045 |
0.317 |
|
| 2016 |
Chen HJ, Wei Z, Sun J, Bhattacharya A, Savage DJ, Serda R, Mackeyev Y, Curley SA, Bu P, Wang L, Chen S, Cohen-Gould L, Huang E, Shen X, Lipkin SM, ... ... Shuler ML, et al. A recellularized human colon model identifies cancer driver genes. Nature Biotechnology. PMID 27398792 DOI: 10.1038/Nbt.3586 |
0.31 |
|
| 2016 |
Esch MB, Ueno H, Applegate DR, Shuler ML. Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue. Lab On a Chip. PMID 27332143 DOI: 10.1039/C6Lc00461J |
0.36 |
|
| 2016 |
Miller PG, Shuler ML. Design and demonstration of a pumpless 14 compartment microphysiological system. Biotechnology and Bioengineering. PMID 27070809 DOI: 10.1002/Bit.25989 |
0.362 |
|
| 2016 |
Oleaga C, Bernabini C, Smith AS, Srinivasan B, Jackson M, McLamb W, Platt V, Bridges R, Cai Y, Santhanam N, Berry B, Najjar S, Akanda N, Guo X, Martin C, ... ... Shuler ML, et al. Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs. Scientific Reports. 6: 20030. PMID 26837601 DOI: 10.1038/Srep20030 |
0.314 |
|
| 2015 |
Esch MB, Prot JM, Wang YI, Miller P, Llamas-Vidales JR, Naughton BA, Applegate DR, Shuler ML. Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow. Lab On a Chip. 15: 2269-77. PMID 25857666 DOI: 10.1039/C5Lc00237K |
0.373 |
|
| 2015 |
Che SP, DeLeonardis C, Shuler ML, Stokol T. Tissue factor-expressing tumor cells can bind to immobilized recombinant tissue factor pathway inhibitor under static and shear conditions in vitro. Plos One. 10: e0123717. PMID 25849335 DOI: 10.1371/Journal.Pone.0123717 |
0.306 |
|
| 2015 |
Srinivasan B, Kolli AR, Esch MB, Abaci HE, Shuler ML, Hickman JJ. TEER measurement techniques for in vitro barrier model systems. Journal of Laboratory Automation. 20: 107-26. PMID 25586998 DOI: 10.1177/2211068214561025 |
0.342 |
|
| 2015 |
Abaci HE, Gledhill K, Guo Z, Christiano AM, Shuler ML. Pumpless microfluidic platform for drug testing on human skin equivalents. Lab On a Chip. 15: 882-8. PMID 25490891 DOI: 10.1039/C4Lc00999A |
0.326 |
|
| 2014 |
Sung JH, Srinivasan B, Esch MB, McLamb WT, Bernabini C, Shuler ML, Hickman JJ. Using physiologically-based pharmacokinetic-guided "body-on-a-chip" systems to predict mammalian response to drug and chemical exposure. Experimental Biology and Medicine (Maywood, N.J.). 239: 1225-39. PMID 24951471 DOI: 10.1177/1535370214529397 |
0.517 |
|
| 2013 |
Smith AS, Long CJ, Berry BJ, McAleer C, Stancescu M, Molnar P, Miller PG, Esch MB, Prot JM, Hickman JJ, Shuler ML. Microphysiological systems and low-cost microfluidic platform with analytics. Stem Cell Research & Therapy. 4: S9. PMID 24565109 DOI: 10.1186/Scrt370 |
0.388 |
|
| 2013 |
Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, ... ... Shuler ML, et al. A physical sciences network characterization of non-tumorigenic and metastatic cells. Scientific Reports. 3: 1449. PMID 23618955 DOI: 10.1038/Srep01449 |
0.331 |
|
| 2013 |
Sung JH, Esch MB, Prot JM, Long CJ, Smith A, Hickman JJ, Shuler ML. Microfabricated mammalian organ systems and their integration into models of whole animals and humans. Lab On a Chip. 13: 1201-12. PMID 23388858 DOI: 10.1039/C3Lc41017J |
0.502 |
|
| 2012 |
Esch MB, Sung JH, Yang J, Yu C, Yu J, March JC, Shuler ML. On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic 'body-on-a-chip' devices. Biomedical Microdevices. 14: 895-906. PMID 22847474 DOI: 10.1007/S10544-012-9669-0 |
0.509 |
|
| 2012 |
Shuler ML, Foley P, Atlas J. Modeling a minimal cell. Methods in Molecular Biology (Clifton, N.J.). 881: 573-610. PMID 22639227 DOI: 10.1007/978-1-61779-827-6_20 |
0.802 |
|
| 2012 |
Shuler ML, Sung JH. Introduction to the special issue on micro- and nanofabrication techniques. Annals of Biomedical Engineering. 40: 1209-10. PMID 22588511 DOI: 10.1007/S10439-012-0589-1 |
0.429 |
|
| 2012 |
Kim BJ, Diao J, Shuler ML. Mini-scale bioprocessing systems for highly parallel animal cell cultures. Biotechnology Progress. 28: 595-607. PMID 22522970 DOI: 10.1002/Btpr.1554 |
0.739 |
|
| 2012 |
Shayan G, Felix N, Cho Y, Chatzichristidi M, Shuler ML, Ober CK, Lee KH. Synthesis and characterization of high-throughput nanofabricated poly(4-hydroxy styrene) membranes for in vitro models of barrier tissue. Tissue Engineering. Part C, Methods. 18: 667-76. PMID 22435738 DOI: 10.1089/Ten.Tec.2011.0598 |
0.306 |
|
| 2012 |
Sung JH, Shuler ML. Microtechnology for mimicking in vivo tissue environment. Annals of Biomedical Engineering. 40: 1289-300. PMID 22215276 DOI: 10.1007/S10439-011-0491-2 |
0.52 |
|
| 2012 |
Xu H, Wu J, Chu CC, Shuler ML. Development of disposable PDMS micro cell culture analog devices with photopolymerizable hydrogel encapsulating living cells. Biomedical Microdevices. 14: 409-18. PMID 22160484 DOI: 10.1007/S10544-011-9617-4 |
0.487 |
|
| 2012 |
Kim BJ, Zhao T, Young L, Zhou P, Shuler ML. Batch, fed-batch, and microcarrier cultures with CHO cell lines in a pressure-cycle driven miniaturized bioreactor. Biotechnology and Bioengineering. 109: 137-45. PMID 21965160 DOI: 10.1002/Bit.23289 |
0.652 |
|
| 2012 |
Srinivasan V, Pestchanker L, Moser S, Hirasuna TJ, Taticek RA, Shuler ML. Taxol production in bioreactors: Kinetics of biomass accumulation, nutrient uptake, and taxol production by cell suspensions of Taxus baccata. Biotechnology and Bioengineering. 47: 666-76. PMID 18623447 DOI: 10.1002/Bit.260470607 |
0.355 |
|
| 2012 |
Hsieh KM, Murgel GA, Lion LW, Shuler ML. Interactions of microbial biofilms with toxic trace metals: 2. Prediction and verification of an integrated computer model of lead (II) distribution in the presence of microbial activity. Biotechnology and Bioengineering. 44: 232-9. PMID 18618689 DOI: 10.1002/Bit.260440212 |
0.303 |
|
| 2012 |
Hsieh KM, Murgel GA, Lion LW, Shuler ML. Interactions of microbial biofilms with toxic trace metals: 1. Observation and modeling of cell growth, attachment, and production of extracellular polymer. Biotechnology and Bioengineering. 44: 219-31. PMID 18618688 DOI: 10.1002/Bit.260440211 |
0.343 |
|
| 2012 |
Payne GF, Payne NN, Shuler ML. Bioreactor considerations for secondary metabolite production from plant cell tissue culture: Indole alkaloids from Catharanthus roseus. Biotechnology and Bioengineering. 31: 905-12. PMID 18584698 DOI: 10.1002/Bit.260310903 |
0.362 |
|
| 2012 |
Georgiou G, Shuler ML. A computer model for the growth and differentiation of a fungal colony on solid substrate. Biotechnology and Bioengineering. 28: 405-16. PMID 18555342 DOI: 10.1002/Bit.260280314 |
0.508 |
|
| 2011 |
Seker E, Sung JH, Shuler ML, Yarmush ML. Solving medical problems with BioMEMS. Ieee Pulse. 2: 51-9. PMID 22147069 DOI: 10.1109/Mpul.2011.942928 |
0.365 |
|
| 2011 |
Shayan G, Shuler ML, Lee KH. The effect of astrocytes on the induction of barrier properties in aortic endothelial cells. Biotechnology Progress. 27: 1137-45. PMID 21626719 DOI: 10.1002/Btpr.620 |
0.301 |
|
| 2011 |
Esch MB, King TL, Shuler ML. The role of body-on-a-chip devices in drug and toxicity studies Annual Review of Biomedical Engineering. 13: 55-72. PMID 21513459 DOI: 10.1146/Annurev-Bioeng-071910-124629 |
0.347 |
|
| 2011 |
Frampton JP, Hynd MR, Shuler ML, Shain W. Fabrication and optimization of alginate hydrogel constructs for use in 3D neural cell culture. Biomedical Materials (Bristol, England). 6: 015002. PMID 21205998 DOI: 10.1088/1748-6041/6/1/015002 |
0.409 |
|
| 2011 |
Sung JH, Yu J, Luo D, Shuler ML, March JC. Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model. Lab On a Chip. 11: 389-92. PMID 21157619 DOI: 10.1039/C0Lc00273A |
0.593 |
|
| 2011 |
Shayan G, Choi YS, Shusta EV, Shuler ML, Lee KH. Murine in vitro model of the blood-brain barrier for evaluating drug transport. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 42: 148-55. PMID 21078386 DOI: 10.1016/J.Ejps.2010.11.005 |
0.316 |
|
| 2010 |
Sung JH, Esch MB, Shuler ML. Integration of in silico and in vitro platforms for pharmacokinetic-pharmacodynamic modeling. Expert Opinion On Drug Metabolism & Toxicology. 6: 1063-81. PMID 20540627 DOI: 10.1517/17425255.2010.496251 |
0.501 |
|
| 2010 |
Choi JR, Sung JH, Shuler ML, Kim D. Investigation of portable in situ fluorescence optical detection for microfluidic 3D cell culture assays. Optics Letters. 35: 1374-6. PMID 20436574 DOI: 10.1364/Ol.35.001374 |
0.574 |
|
| 2010 |
Frampton JP, Hynd MR, Shuler ML, Shain W. Effects of glial cells on electrode impedance recorded from neuralprosthetic devices in vitro. Annals of Biomedical Engineering. 38: 1031-47. PMID 20336824 DOI: 10.1007/S10439-010-9911-Y |
0.319 |
|
| 2010 |
Esch MB, Sung JH, Shuler ML. Promises, challenges and future directions of microCCAs. Journal of Biotechnology. 148: 64-9. PMID 20193719 DOI: 10.1016/J.Jbiotec.2010.02.020 |
0.552 |
|
| 2010 |
Sung JH, Kam C, Shuler ML. A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip. Lab On a Chip. 10: 446-55. PMID 20126684 DOI: 10.1039/B917763A |
0.55 |
|
| 2010 |
Kim BJ, Schneider DJ, Cartinhour SW, Shuler ML. Complex responses to culture conditions in Pseudomonas syringae pv. tomato DC3000 continuous cultures: the role of iron in cell growth and virulence factor induction. Biotechnology and Bioengineering. 105: 955-64. PMID 19953673 DOI: 10.1002/Bit.22609 |
0.585 |
|
| 2010 |
Foley PL, Shuler ML. Considerations for the design and construction of a synthetic platform cell for biotechnological applications Biotechnology and Bioengineering. 105: 26-36. PMID 19816966 DOI: 10.1002/Bit.22575 |
0.417 |
|
| 2010 |
Sung JH, Shuler ML. In vitro microscale systems for systematic drug toxicity study. Bioprocess and Biosystems Engineering. 33: 5-19. PMID 19701779 DOI: 10.1007/S00449-009-0369-Y |
0.532 |
|
| 2010 |
Georgiou G, Shuler ML, Wilson DB. Release of periplasmic enzymes and other physiological effects of beta-lactamase overproduction in Escherichia coli. Biotechnology and Bioengineering. 32: 741-8. PMID 18587779 DOI: 10.1002/Bit.260320603 |
0.475 |
|
| 2010 |
Shuler ML, Esch MB. Body-on-a chip: Using microfluidic systems to predict human responses to drugs Pure and Applied Chemistry. 82: 1635-1645. DOI: 10.1351/Pac-Con-09-10-44 |
0.381 |
|
| 2010 |
Choi JR, Sung JH, Shuler ML, Kim D. Confocal fluorescence detection for 3D cultured mammalian cells in a microfluidic cell culture system Progress in Biomedical Optics and Imaging - Proceedings of Spie. 7568. DOI: 10.1117/12.841729 |
0.566 |
|
| 2009 |
Sung JH, Choi JR, Kim D, Shuler ML. Fluorescence optical detection in situ for real-time monitoring of cytochrome P450 enzymatic activity of liver cells in multiple microfluidic devices. Biotechnology and Bioengineering. 104: 516-25. PMID 19575443 DOI: 10.1002/Bit.22413 |
0.557 |
|
| 2009 |
Mahler GJ, Esch MB, Glahn RP, Shuler ML. Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity. Biotechnology and Bioengineering. 104: 193-205. PMID 19418562 DOI: 10.1002/Bit.22366 |
0.367 |
|
| 2009 |
Sung JH, Shuler ML. A micro cell culture analog (microCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs. Lab On a Chip. 9: 1385-94. PMID 19417905 DOI: 10.1039/B901377F |
0.589 |
|
| 2009 |
Xu H, Shuler ML. Quantification of chemical-polymer surface interactions in microfluidic cell culture devices. Biotechnology Progress. 25: 543-51. PMID 19358211 DOI: 10.1002/Btpr.135 |
0.422 |
|
| 2009 |
Kim BJ, Park JH, Park TH, Bronstein PA, Schneider DJ, Cartinhour SW, Shuler ML. Effect of iron concentration on the growth rate of Pseudomonas syringae and the expression of virulence factors in hrp-inducing minimal medium. Applied and Environmental Microbiology. 75: 2720-6. PMID 19270129 DOI: 10.1128/Aem.02738-08 |
0.534 |
|
| 2009 |
Sung JH, Shuler ML. Prevention of air bubble formation in a microfluidic perfusion cell culture system using a microscale bubble trap. Biomedical Microdevices. 11: 731-8. PMID 19212816 DOI: 10.1007/S10544-009-9286-8 |
0.525 |
|
| 2009 |
Tatosian DA, Shuler ML. A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers. Biotechnology and Bioengineering. 103: 187-98. PMID 19137589 DOI: 10.1002/Bit.22219 |
0.739 |
|
| 2009 |
Echtenkamp PL, Wilson DB, Shuler ML. Cell cycle progression in Escherichia coli B/r affects transcription of certain genes: Implications for synthetic genome design. Biotechnology and Bioengineering. 102: 902-9. PMID 18823050 DOI: 10.1002/Bit.22098 |
0.756 |
|
| 2009 |
Sung JH, Dhiman A, Shuler ML. A combined pharmacokinetic-pharmacodynamic (PK-PD) model for tumor growth in the rat with UFT administration. Journal of Pharmaceutical Sciences. 98: 1885-904. PMID 18803264 DOI: 10.1002/Jps.21536 |
0.501 |
|
| 2009 |
Mahler GJ, Shuler ML, Glahn RP. Characterization of Caco-2 and HT29-MTX cocultures in an in vitro digestion/cell culture model used to predict iron bioavailability. The Journal of Nutritional Biochemistry. 20: 494-502. PMID 18715773 DOI: 10.1016/J.Jnutbio.2008.05.006 |
0.317 |
|
| 2009 |
Shibasaki-Kitakawa N, Miyamoto T, Kubo M, Uozumi N, Toriyama K, Yonemoto T, Shuler ML. Production of human secreted alkaline phosphatase in suspension and immobilization cultures of tobacco NT1 cells Journal of Bioscience and Bioengineering. 108: S5. DOI: 10.1016/J.Bej.2013.06.004 |
0.39 |
|
| 2008 |
Frampton JP, Shuler ML, Shain W, Hynd MR. Biomedical Technologies for in vitro Screening and Controlled Delivery of Neuroactive Compounds. Central Nervous System Agents in Medicinal Chemistry. 8: 203-219. PMID 19079777 DOI: 10.2174/187152408785699613 |
0.411 |
|
| 2008 |
Atlas JC, Nikolaev EV, Browning ST, Shuler ML. Incorporating genome-wide DNA sequence information into a dynamic whole-cell model of Escherichia coli: application to DNA replication. Iet Systems Biology. 2: 369-82. PMID 19045832 DOI: 10.1049/Iet-Syb:20070079 |
0.789 |
|
| 2008 |
Xu H, Kraus WL, Shuler ML. Development of a stable dual cell-line GFP expression system to study estrogenic endocrine disruptors. Biotechnology and Bioengineering. 101: 1276-87. PMID 18980187 DOI: 10.1002/Bit.21991 |
0.437 |
|
| 2008 |
McAuliffe GJ, Chang JY, Glahn RP, Shuler ML. Development of a gastrointestinal tract microscale cell culture analog to predict drug transport. Molecular & Cellular Biomechanics : McB. 5: 119-32. PMID 18589500 |
0.772 |
|
| 2008 |
Kim JY, Doody AM, Chen DJ, Cremona GH, Shuler ML, Putnam D, DeLisa MP. Engineered bacterial outer membrane vesicles with enhanced functionality. Journal of Molecular Biology. 380: 51-66. PMID 18511069 DOI: 10.1016/J.Jmb.2008.03.076 |
0.576 |
|
| 2008 |
Diao J, Young L, Zhou P, Shuler ML. An actively mixed mini-bioreactor for protein production from suspended animal cells. Biotechnology and Bioengineering. 100: 72-81. PMID 18078290 DOI: 10.1002/Bit.21751 |
0.631 |
|
| 2008 |
Shuler ML, Tatosian DA, Sung JH. Can we predict how humans will respond to drugs? Aiche Annual Meeting, Conference Proceedings. |
0.721 |
|
| 2008 |
Shuler ML, Atlas JC, Nikolaev EV. Do we know enough to reconstruct life in silico? Aiche Annual Meeting, Conference Proceedings. |
0.738 |
|
| 2007 |
Frampton JP, Hynd MR, Williams JC, Shuler ML, Shain W. Three-dimensional hydrogel cultures for modeling changes in tissue impedance around microfabricated neural probes. Journal of Neural Engineering. 4: 399-409. PMID 18057507 DOI: 10.1088/1741-2560/4/4/006 |
0.354 |
|
| 2007 |
Oh TI, Sung JH, Tatosian DA, Shuler ML, Kim D. Real-time fluorescence detection of multiple microscale cell culture analog devices in situ. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 71: 857-65. PMID 17559134 DOI: 10.1002/Cyto.A.20427 |
0.79 |
|
| 2007 |
Cheng SY, Heilman S, Wasserman M, Archer S, Shuler ML, Wu M. A hydrogel-based microfluidic device for the studies of directed cell migration. Lab On a Chip. 7: 763-9. PMID 17538719 DOI: 10.1039/B618463D |
0.333 |
|
| 2007 |
Nikolaev EV, Atlas JC, Shuler ML. Sensitivity and control analysis of periodically forced reaction networks using the Green's function method. Journal of Theoretical Biology. 247: 442-61. PMID 17481665 DOI: 10.1016/J.Jtbi.2007.02.013 |
0.754 |
|
| 2007 |
Becerra-Arteaga A, Shuler ML. Influence of culture medium supplementation of tobacco NT1 cell suspension cultures on the N-glycosylation of human secreted alkaline phosphatase. Biotechnology and Bioengineering. 97: 1585-93. PMID 17238209 DOI: 10.1002/Bit.21344 |
0.376 |
|
| 2007 |
Lee SJ, Kim HS, Kim SJ, Park S, Kim BJ, Shuler ML, Lee EY. Cloning, expression and enantioselective hydrolytic catalysis of a microsomal epoxide hydrolase from a marine fish, Mugil cephalus. Biotechnology Letters. 29: 237-46. PMID 17151961 DOI: 10.1007/S10529-006-9222-4 |
0.536 |
|
| 2007 |
Castellanos M, Kushiro K, Lai SK, Shuler ML. A genomically/chemically complete module for synthesis of lipid membrane in a minimal cell. Biotechnology and Bioengineering. 97: 397-409. PMID 17149771 DOI: 10.1002/Bit.21251 |
0.619 |
|
| 2007 |
Oh TI, Kim D, Tatosian D, Sung JH, Shuler M. Real-time quantitative fluorescence measurement of microscale cell culture analog systems Progress in Biomedical Optics and Imaging - Proceedings of Spie. 6441. DOI: 10.1117/12.700610 |
0.79 |
|
| 2007 |
Webster IA, Shuler ML. The measurement of effective substrate diffusities within whole cell suspensions using a diffusion‐limited hollow fibre reactor Journal of Chemical Technology & Biotechnology. 31: 226-234. DOI: 10.1002/Jctb.503310131 |
0.341 |
|
| 2006 |
Becerra-Arteaga A, Mason HS, Shuler ML. Production, secretion, and stability of human secreted alkaline phosphatase in tobacco NT1 cell suspension cultures. Biotechnology Progress. 22: 1643-9. PMID 17137313 DOI: 10.1021/Bp060151R |
0.388 |
|
| 2006 |
Pla IA, Damasceno LM, Vannelli T, Ritter G, Batt CA, Shuler ML. Evaluation of Mut+ and MutS Pichia pastoris phenotypes for high level extracellular scFv expression under feedback control of the methanol concentration. Biotechnology Progress. 22: 881-8. PMID 16739975 DOI: 10.1021/bp060012 |
0.782 |
|
| 2006 |
Kim BJ, Gibson DM, Shuler ML. Effect of the plant peptide regulator, phytosulfokine-alpha, on the growth and Taxol production from Taxus sp. suspension cultures. Biotechnology and Bioengineering. 95: 8-14. PMID 16586507 DOI: 10.1002/Bit.20934 |
0.567 |
|
| 2006 |
Diao J, Young L, Kim S, Fogarty EA, Heilman SM, Zhou P, Shuler ML, Wu M, DeLisa MP. A three-channel microfluidic device for generating static linear gradients and its application to the quantitative analysis of bacterial chemotaxis. Lab On a Chip. 6: 381-8. PMID 16511621 DOI: 10.1039/B511958H |
0.701 |
|
| 2006 |
Kim D, Tatosian DA, Shuler ML. Portable real-time fluorescence cytometry of microscale cell culture analog devices Progress in Biomedical Optics and Imaging - Proceedings of Spie. 6088. DOI: 10.1117/12.644521 |
0.74 |
|
| 2006 |
Nikolaev EV, Atlas JC, Shuler ML. Computer models of bacterial cells: From generalized coarsegrained to genome-specific modular models Journal of Physics: Conference Series. 46: 322-326. DOI: 10.1088/1742-6596/46/1/045 |
0.796 |
|
| 2005 |
Tatosian DA, Shuler ML, Kim D. Portable in situ fluorescence cytometry of microscale cell-based assays. Optics Letters. 30: 1689-91. PMID 16075539 DOI: 10.1364/Ol.30.001689 |
0.75 |
|
| 2005 |
Kim BJ, Gibson DM, Shuler ML. Relationship of viability and apoptosis to taxol production in Taxus sp. suspension cultures elicited with methyl jasmonate. Biotechnology Progress. 21: 700-7. PMID 15932245 DOI: 10.1021/Bp050016Z |
0.587 |
|
| 2005 |
Ma SH, Lepak LA, Hussain RJ, Shain W, Shuler ML. An endothelial and astrocyte co-culture model of the blood-brain barrier utilizing an ultra-thin, nanofabricated silicon nitride membrane. Lab On a Chip. 5: 74-85. PMID 15616743 DOI: 10.1039/B405713A |
0.332 |
|
| 2005 |
Li X, Shuler ML. The development of a microscale cell culture analog device for toxicity study Aiche Annual Meeting, Conference Proceedings. 14197. |
0.314 |
|
| 2005 |
Wang CK, Shuler ML. Derivation of non-anthocyanin-producing grape cell culture from a stable anthocyanin-producing grape cell culture: An example of reverse engineering Aiche Annual Meeting, Conference Proceedings. 8116-8127. |
0.304 |
|
| 2005 |
Tatosian DA, Shuler ML. A cell culture analog for multidrug resistant cancer chemotherapy screening Aiche Annual Meeting, Conference Proceedings. 8648. |
0.743 |
|
| 2005 |
Li X, Shuler ML. The development of a three-dimensional microscale cell culture analog device for toxicity study Aiche Annual Meeting, Conference Proceedings. 8822. |
0.312 |
|
| 2005 |
Diao J, Young L, Zhou P, Shuler ML. A highly integrated on-chip glycoprotein processor for rapid sialic acid content monitoring Aiche Annual Meeting, Conference Proceedings. 8191. |
0.514 |
|
| 2005 |
Castellanos M, Lai S, Kushiro K, Shuler ML. Membrane descriptions for a mathematical model of a minimal cell Aiche Annual Meeting, Conference Proceedings. 8968. |
0.579 |
|
| 2004 |
Kim BJ, Gibson DM, Shuler ML. Effect of subculture and elicitation on instability of taxol production in Taxus sp. suspension cultures. Biotechnology Progress. 20: 1666-73. PMID 15575697 DOI: 10.1021/Bp034274C |
0.606 |
|
| 2004 |
Browning ST, Castellanos M, Shuler ML. Robust control of initiation of prokaryotic chromosome replication: essential considerations for a minimal cell. Biotechnology and Bioengineering. 88: 575-84. PMID 15470709 DOI: 10.1002/Bit.20223 |
0.617 |
|
| 2004 |
Joosten CE, Cohen LS, Ritter G, Batt CA, Shuler ML. Glycosylation profiles of the human colorectal cancer A33 antigen naturally expressed in the human colorectal cancer cell line SW1222 and expressed as recombinant protein in different insect cell lines. Biotechnology Progress. 20: 1273-9. PMID 15296462 DOI: 10.1021/Bp034378N |
0.782 |
|
| 2004 |
Viravaidya K, Jan E, Shuler ML. Lipid-gel and poly(dimethylsiloxane) film to mimic bioaccumulation in adipocytes. Biotechnology and Bioengineering. 86: 643-9. PMID 15137075 DOI: 10.1002/Bit.20109 |
0.766 |
|
| 2004 |
Castellanos M, Wilson DB, Shuler ML. A modular minimal cell model: purine and pyrimidine transport and metabolism. Proceedings of the National Academy of Sciences of the United States of America. 101: 6681-6. PMID 15090651 DOI: 10.1073/Pnas.0400962101 |
0.656 |
|
| 2004 |
Viravaidya K, Shuler ML. Incorporation of 3T3-L1 cells to mimic bioaccumulation in a microscale cell culture analog device for toxicity studies. Biotechnology Progress. 20: 590-7. PMID 15059006 DOI: 10.1021/Bp034238D |
0.788 |
|
| 2004 |
Sin A, Chin KC, Jamil MF, Kostov Y, Rao G, Shuler ML. The design and fabrication of three-chamber microscale cell culture analog devices with integrated dissolved oxygen sensors. Biotechnology Progress. 20: 338-45. PMID 14763861 DOI: 10.1021/Bp034077D |
0.639 |
|
| 2004 |
Viravaidya K, Sin A, Shuler ML. Development of a microscale cell culture analog to probe naphthalene toxicity. Biotechnology Progress. 20: 316-23. PMID 14763858 DOI: 10.1021/Bp0341996 |
0.801 |
|
| 2004 |
Sin A, Reardon CF, Shuler ML. A self-priming microfluidic diaphragm pump capable of recirculation fabricated by combining soft lithography and traditional machining. Biotechnology and Bioengineering. 85: 359-63. PMID 14748092 DOI: 10.1002/Bit.10787 |
0.563 |
|
| 2004 |
Kim D, Xu H, Kim SJ, Shuler ML. Investigation of doxorubicin for multi-drug resistance using a fluorescent cytometric imaging system integrated onto cell culture analog devices Proceedings of Spie - the International Society For Optical Engineering. 5325: 122-127. DOI: 10.1117/12.523626 |
0.479 |
|
| 2004 |
Shuler ML, Archer SD, Castellanos M. Hybrid models: Relating genomic detail to cell physiology and extracellular environment Aiche Annual Meeting, Conference Proceedings. 9277-9288. |
0.579 |
|
| 2003 |
Smith ML, Richter L, Arntzen CJ, Shuler ML, Mason HS. Structural characterization of plant-derived hepatitis B surface antigen employed in oral immunization studies. Vaccine. 21: 4011-21. PMID 12922138 DOI: 10.1016/S0264-410X(03)00268-8 |
0.472 |
|
| 2003 |
Joosten CE, Park TH, Shuler ML. Effect of silkworm hemolymph on N-linked glycosylation in two Trichoplusia ni insect cell lines. Biotechnology and Bioengineering. 83: 695-705. PMID 12889034 DOI: 10.1002/Bit.10696 |
0.799 |
|
| 2003 |
Roberts SC, Naill M, Gibson DM, Shuler ML. A simple method for enhancing paclitaxel release from Taxus canadensis cell suspension cultures utilizing cell wall digesting enzymes. Plant Cell Reports. 21: 1217-20. PMID 12811504 DOI: 10.1007/S00299-003-0575-Z |
0.411 |
|
| 2003 |
Joosten CE, Shuler ML. Effect of culture conditions on the degree of sialylation of a recombinant glycoprotein expressed in insect cells. Biotechnology Progress. 19: 739-49. PMID 12790633 DOI: 10.1021/Bp0201049 |
0.805 |
|
| 2003 |
Park TH, Shuler ML. Integration of cell culture and microfabrication technology. Biotechnology Progress. 19: 243-53. PMID 12675556 DOI: 10.1021/Bp020143K |
0.43 |
|
| 2003 |
Joosten CE, Shuler ML. Production of a sialylated N-linked glycoprotein in insect cells: role of glycosidases and effect of harvest time on glycosylation. Biotechnology Progress. 19: 193-201. PMID 12573025 DOI: 10.1021/Bp025695H |
0.789 |
|
| 2003 |
Palomares LA, Joosten CE, Hughes PR, Granados RR, Shuler ML. Novel insect cell line capable of complex N-glycosylation and sialylation of recombinant proteins. Biotechnology Progress. 19: 185-92. PMID 12573024 DOI: 10.1021/Bp025598O |
0.799 |
|
| 2003 |
Harris SG, Shuler ML. Growth of endothelial cells on microfabricated silicon nitride membranes for an In Vitro model of the blood-brain barrier Biotechnology and Bioprocess Engineering. 8: 246-251. DOI: 10.1007/Bf02942273 |
0.35 |
|
| 2002 |
Brincat MC, Gibson DM, Shuler ML. Alterations in Taxol production in plant cell culture via manipulation of the phenylalanine ammonia lyase pathway. Biotechnology Progress. 18: 1149-56. PMID 12467445 DOI: 10.1021/Bp0256115 |
0.31 |
|
| 2002 |
Smith ML, Mason HS, Shuler ML. Hepatitis B surface antigen (HBsAg) expression in plant cell culture: Kinetics of antigen accumulation in batch culture and its intracellular form. Biotechnology and Bioengineering. 80: 812-22. PMID 12402327 DOI: 10.1002/Bit.10444 |
0.535 |
|
| 2002 |
Lee-Parsons CW, Shuler ML. The effect of ajmalicine spiking and resin addition timing on the production of indole alkaloids from Catharanthus roseus cell cultures. Biotechnology and Bioengineering. 79: 408-15. PMID 12115404 DOI: 10.1002/Bit.10235 |
0.333 |
|
| 2002 |
Smith ML, Keegan ME, Mason HS, Shuler ML. Factors important in the extraction, stability and in vitro assembly of the hepatitis B surface antigen derived from recombinant plant systems. Biotechnology Progress. 18: 538-50. PMID 12052071 DOI: 10.1021/Bp010169W |
0.499 |
|
| 2002 |
Viravaidya K, Shuler ML. The effect of various substrates on cell attachment and differentiation of 3T3-F442A preadipocytes. Biotechnology and Bioengineering. 78: 454-8. PMID 11948452 DOI: 10.1002/Bit.10219 |
0.79 |
|
| 2002 |
Viravaidya K, Shuler ML. Prediction of naphthalene bioaccumulation using an adipocyte cell line model. Biotechnology Progress. 18: 174-81. PMID 11934283 DOI: 10.1021/Bp0101684 |
0.801 |
|
| 2001 |
Browning ST, Shuler ML. Towards the development of a minimal cell model by generalization of a model of Escherichia coli: Use of dimensionless rate Parameters Biotechnology and Bioengineering. 76: 187-192. PMID 11668452 DOI: 10.1002/Bit.10007 |
0.367 |
|
| 2001 |
Joshi L, Shuler ML, Wood HA. Production of a sialylated N-linked glycoprotein in insect cells. Biotechnology Progress. 17: 822-7. PMID 11587569 DOI: 10.1021/Bp010071H |
0.386 |
|
| 2001 |
Taticek RA, Choi C, Phan SE, Palomares LA, Shuler ML. Comparison of growth and recombinant protein expression in two different insect cell lines in attached and suspension culture. Biotechnology Progress. 17: 676-84. PMID 11485429 DOI: 10.1021/bp010061g |
0.307 |
|
| 2001 |
Sin A, Baxter GT, Shuler ML. Animal on a chip: A microscale cell culture analog device for evaluating toxicological and pharmacological profiles Proceedings of Spie - the International Society For Optical Engineering. 4560: 98-101. DOI: 10.1117/12.443045 |
0.627 |
|
| 2000 |
Ghanem A, Shuler ML. Characterization of a perfusion reactor utilizing mammalian cells on microcarrier beads Biotechnology Progress. 16: 471-479. PMID 10835251 DOI: 10.1021/Bp000047O |
0.455 |
|
| 2000 |
Ghanem A, Shuler ML. Combining cell culture analogue reactor designs and PBPK models to probe mechanisms of naphthalene toxicity Biotechnology Progress. 16: 334-345. PMID 10835232 DOI: 10.1021/Bp9901522 |
0.444 |
|
| 2000 |
Lee CWT, Shuler ML. The effect of inoculum density and conditioned medium on the production of ajmalicine and catharanthine from immobilized Catharanthus roseus cells Biotechnology and Bioengineering. 67: 61-71. PMID 10581436 DOI: 10.1002/(Sici)1097-0290(20000105)67:1<61::Aid-Bit7>3.0.Co;2-J |
0.353 |
|
| 1999 |
Ketchum RE, Tandon M, Gibson DM, Begley T, Shuler ML. Isolation of labeled 9-dihydrobaccatin III and related taxoids from cell cultures of taxuscell cultures of taxus canadensis elicited with m. Journal of Natural Products. 62: 1395-8. PMID 10543900 DOI: 10.1021/Np990201K |
0.346 |
|
| 1999 |
Shuler ML. Single-cell models: Promise and limitations Journal of Biotechnology. 71: 225-228. PMID 10483108 DOI: 10.1016/S0168-1656(99)00024-3 |
0.354 |
|
| 1999 |
Ahn IS, Ghiorse WC, Lion LW, Shuler ML. Independent prediction of naphthalene transport and biodegradation in soil with a mathematical model Biotechnology and Bioengineering. 65: 65-75. PMID 10440672 DOI: 10.1002/(Sici)1097-0290(19991005)65:1<65::Aid-Bit8>3.0.Co;2-K |
0.314 |
|
| 1999 |
Quick DJ, Shuler ML. Use of in vitro data for construction of a physiologically based pharmacokinetic model for naphthalene in rats and mice to probe species differences. Biotechnology Progress. 15: 540-55. PMID 10356275 DOI: 10.1021/Bp990057T |
0.341 |
|
| 1999 |
Donaldson M, Wood HA, Kulakosky PC, Shuler ML. Glycosylation of a recombinant protein in the Tn5B1-4 insect cell line: influence of ammonia, time of harvest, temperature, and dissolved oxygen. Biotechnology and Bioengineering. 63: 255-62. PMID 10099604 DOI: 10.1002/(Sici)1097-0290(19990505)63:3<255::Aid-Bit1>3.0.Co;2-R |
0.362 |
|
| 1999 |
Ketchum RE, Gibson DM, Croteau RB, Shuler ML. The kinetics of taxoid accumulation in cell suspension cultures of Taxus following elicitation with methyl jasmonate. Biotechnology and Bioengineering. 62: 97-105. PMID 10099517 DOI: 10.1002/(Sici)1097-0290(19990105)62:1<97::Aid-Bit11>3.0.Co;2-C |
0.373 |
|
| 1999 |
Donaldson MS, Shuler ML. The use of lectins to select subpopulations of insect cells Biotechnology and Bioengineering. 64: 616-619. DOI: 10.1002/(Sici)1097-0290(19990905)64:5<616::Aid-Bit12>3.0.Co;2-W |
0.362 |
|
| 1998 |
Ahn IS, Ghiorse WC, Lion LW, Shuler ML. Growth kinetics of Pseudomonas putida G7 on naphthalene and occurrence of naphthalene toxicity during nutrient deprivation Biotechnology and Bioengineering. 59: 587-594. PMID 10099376 DOI: 10.1002/(Sici)1097-0290(19980905)59:5<587::Aid-Bit9>3.0.Co;2-6 |
0.312 |
|
| 1998 |
Donaldson MS, Shuler ML. Low-cost serum-free medium for the BTI-Tn5b1-4 insect cell line Biotechnology Progress. 14: 573-579. PMID 9694678 DOI: 10.1021/Bp9800541 |
0.415 |
|
| 1998 |
Donaldson MS, Shuler ML. Effects of long-term passaging of BTI-Tn5B1-4 insect cells on growth and recombinant protein production Biotechnology Progress. 14: 543-547. PMID 9694673 DOI: 10.1021/Bp9800485 |
0.436 |
|
| 1998 |
Kulakosky PC, Shuler ML, Wood HA. N-glycosylation of a baculovirus-expressed recombinant glycoprotein in three insect cell lines. In Vitro Cellular & Developmental Biology. Animal. 34: 101-8. PMID 9542646 DOI: 10.1007/S11626-998-0091-0 |
0.388 |
|
| 1998 |
Mufti NA, Shuler ML. Different in vitro systems affect CYPIA1 activity in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin Toxicology in Vitro. 12: 259-272. DOI: 10.1016/S0887-2333(97)00114-8 |
0.312 |
|
| 1997 |
Srinivasan V, Roberts SC, Shuler ML. Combined use of six-well polystyrene plates and thin layer chromatography for rapid development of optimal plant cell culture processes: application to taxane production byTaxus sp. Plant Cell Reports. 16: 600-604. PMID 30727603 DOI: 10.1007/Bf01275499 |
0.374 |
|
| 1997 |
Dee KU, Wood HA, Shuler ML. Inducing single-cell suspension of BTI-TN5B1-4 insect cells: II. The effect of sulfated polyanions on baculovirus infection. Biotechnology and Bioengineering. 54: 206-20. PMID 18634087 DOI: 10.1002/(Sici)1097-0290(19970505)54:3<206::Aid-Bit2>3.0.Co;2-J |
0.345 |
|
| 1997 |
Dee KU, Shuler ML, Wood HA. Inducing single-cell suspension of BTI-TN5B1-4 insect cells: I. The use of sulfated polyanions to prevent cell aggregation and enhance recombinant protein production. Biotechnology and Bioengineering. 54: 191-205. PMID 18634086 DOI: 10.1002/(Sici)1097-0290(19970505)54:3<191::Aid-Bit1>3.0.Co;2-A |
0.412 |
|
| 1997 |
Roberts SC, Shuler ML. Large-scale plant cell culture. Current Opinion in Biotechnology. 8: 154-9. PMID 9079728 DOI: 10.1016/S0958-1669(97)80094-8 |
0.34 |
|
| 1997 |
Taticek R, McKenna K, Granados R, Shuler ML. Biotechnology Techniques. 11: 237-240. DOI: 10.1023/A:1018482304052 |
0.407 |
|
| 1997 |
McKenna KA, Shuler ML, Granados RR. Increased virus production in suspension culture by a trichoplusia in cell line in serum-free media Biotechnology Progress. 13: 805-809. DOI: 10.1021/Bp9700925 |
0.422 |
|
| 1997 |
Prince CL, Shuler ML, Yamada Y. Altering flavor profiles in onion (Allium cepa L.) Root cultures through directed biosynthesis Biotechnology Progress. 13: 506-510. DOI: 10.1021/Bp9700566 |
0.332 |
|
| 1997 |
Dee KU, Shuler ML. A mathematical model of the trafficking of acid-dependent enveloped viruses: Application to the binding, uptake, and nuclear accumulation of baculovirus Biotechnology and Bioengineering. 54: 468-490. DOI: 10.1002/(Sici)1097-0290(19970605)54:5<468::Aid-Bit7>3.0.Co;2-C |
0.313 |
|
| 1997 |
Taticek RA, Shuler ML. Effect of elevated oxygen and glutamine levels on foreign protein production at high cell densities using the insect cell-baculovirus expression system Biotechnology and Bioengineering. 54: 142-152. DOI: 10.1002/(Sici)1097-0290(19970420)54:2<142::Aid-Bit6>3.0.Co;2-L |
0.352 |
|
| 1996 |
Shuler ML, Ghanem A, Quick D, Wong MC, Miller P. A self-regulating cell culture analog device to mimic animal and human toxicological responses. Biotechnology and Bioengineering. 52: 45-60. PMID 18629851 DOI: 10.1002/(Sici)1097-0290(19961005)52:1<45::Aid-Bit5>3.0.Co;2-Z |
0.382 |
|
| 1996 |
Pestchanker LJ, Roberts SC, Shuler ML. Kinetics of taxol production and nutrient use in suspension cultures of Taxus cuspidata in shake flasks and a Wilson-type bioreactor. Enzyme and Microbial Technology. 19: 256-60. PMID 8987485 DOI: 10.1016/0141-0229(95)00243-X |
0.331 |
|
| 1996 |
Srinivasan V, Ciddi V, Bringi V, Shuler ML. Metabolic inhibitors, elicitors, and precursors as tools for probing yield limitation in taxane production by Taxus chinensis cell cultures Biotechnology Progress. 12: 457-465. PMID 8987474 DOI: 10.1021/Bp9600344 |
0.382 |
|
| 1996 |
Mufti NA, Shuler ML. Possible role of arachidonic acid in stress-induced cytochrome P450IA1 activity Biotechnology Progress. 12: 847-854. PMID 8983209 DOI: 10.1021/Bp960067J |
0.314 |
|
| 1996 |
Sweeney LM, Shuler ML, Quick DJ, Babish JG. A preliminary physiologically based pharmacokinetic model for naphthalene and naphthalene oxide in mice and rats. Annals of Biomedical Engineering. 24: 305-20. PMID 8678360 DOI: 10.1007/Bf02667357 |
0.303 |
|
| 1996 |
Nelson YM, Lion LW, Shuler ML, Ghiorse WC. Modeling oligotrophic biofilm formation and lead adsorption to biofilm components Environmental Science and Technology. 30: 2027-2035. DOI: 10.1021/Es950819Q |
0.346 |
|
| 1996 |
Hirasuna TJ, Pestchanker LJ, Srinivasan V, Shuler ML. Taxol production in suspension cultures of Taxus baccata Plant Cell, Tissue and Organ Culture. 44: 95-102. DOI: 10.1007/Bf00048185 |
0.357 |
|
| 1995 |
Mufti NA, Shuler ML. Induction of cytochrome P-450IA1 activity in response to sublethal stresses in microcarrier-attached Hep G2 cells Biotechnology Progress. 11: 659-663. PMID 8541016 DOI: 10.1021/Bp00036A009 |
0.326 |
|
| 1995 |
Mufti NA, Bleckwenn NA, Babish JG, Shuler ML. Possible involvement of the Ah receptor in the induction of cytochrome P-450IA1 under conditions of hydrodynamic shear in microcarrier-attached hepatoma cell lines Biochemical and Biophysical Research Communications. 208: 144-152. PMID 7887922 DOI: 10.1006/Bbrc.1995.1316 |
0.349 |
|
| 1995 |
Wickham TJ, Nemerow GR, Wood HA, Shuler ML. Comparison of different cell lines for the production of recombinant baculovirus proteins. Methods in Molecular Biology (Clifton, N.J.). 39: 385-95. PMID 7620559 DOI: 10.1385/0-89603-272-8:385 |
0.335 |
|
| 1995 |
Kumar A, Shuler ML. Model of a split-flow airlift bioreactor for attachment-dependent, baculovirus-infected insect cells Biotechnology Progress. 11: 412-419. DOI: 10.1021/Bp00034A008 |
0.367 |
|
| 1995 |
Sweeney LM, Shuler ML, Babish JG, Ghanem A. A cell culture analogue of rodent physiology: Application to naphthalene toxicology Toxicology in Vitro. 9: 307-316. DOI: 10.1016/0887-2333(95)00007-U |
0.363 |
|
| 1995 |
Nelson YM, Lo W, Lion LW, Shuler ML, Ghiorse WC. Lead distribution in a simulated aquatic environment: Effects of bacterial biofilms and iron oxide Water Research. 29: 1934-1944. DOI: 10.1016/0043-1354(94)00351-7 |
0.305 |
|
| 1995 |
Ciddi V, Srinivasan V, Shuler ML. Elicitation of Taxus sp. cell cultures for production of taxol Biotechnology Letters. 17: 1343-1346. DOI: 10.1007/Bf00189223 |
0.337 |
|
| 1994 |
Shuler ML. Bioreactor engineering as an enabling technology to tap biodiversity - The case of Taxol Annals of the New York Academy of Sciences. 745: 455-461. PMID 7832531 DOI: 10.1111/J.1749-6632.1994.Tb44396.X |
0.346 |
|
| 1994 |
Taticek RA, Lee CW, Shuler ML. Large-scale insect and plant cell culture Current Opinion in Biotechnology. 5: 165-174. PMID 7764795 DOI: 10.1016/S0958-1669(05)80031-X |
0.405 |
|
| 1994 |
Laffend L, Shuler ML. Structured model of genetic control via the lac promoter in Escherichia coli Biotechnology and Bioengineering. 43: 399-410. DOI: 10.1002/Bit.260430508 |
0.331 |
|
| 1993 |
Davis TR, Wickham TJ, McKenna KA, Granados RR, Shuler ML, Wood HA. Comparative recombinant protein production of eight insect cell lines. In Vitro Cellular & Developmental Biology. Animal. 29: 388-90. PMID 8314732 DOI: 10.1007/Bf02633986 |
0.404 |
|
| 1993 |
Chung IS, Taticek RA, Shuler ML. Production of human alkaline phosphatase, a secreted, glycosylated protein, from a baculovirus expression system and the attachment-dependent cell line Trichoplusia ni BTI-Tn 5B1-4 using a split-flow, air-lift bioreactor Biotechnology Progress. 9: 675-678. PMID 7764358 DOI: 10.1021/Bp00024A018 |
0.38 |
|
| 1993 |
Wu P, Ray NG, Shuler ML. A computer model for intracellular pH regulation in Chinese hamster ovary cells Biotechnology Progress. 9: 374-384. PMID 7764066 DOI: 10.1021/Bp00022A004 |
0.339 |
|
| 1993 |
Togna AP, Shuler ML, Wilson DB. Effects of plasmid copy number and runaway plasmid replication on overproduction and excretion of β-lactamase from Escherichia coli Biotechnology Progress. 9: 31-39. PMID 7763410 DOI: 10.1021/Bp00019A005 |
0.334 |
|
| 1993 |
Chung IS, Shuler ML. Effect of Trichoplusia ni BTI-Tn 5B1-4 cell density on human secreted alkaline phosphatase production Biotechnology Letters. 15: 1007-1012. DOI: 10.1007/Bf00129927 |
0.372 |
|
| 1993 |
Togna AP, Fu J, Shuler ML. Use of a simple mathematical model to predict the behavior of Escherichia coli overproducing β-lactamase within continuous single- and two-stage reactor systems Biotechnology and Bioengineering. 42: 557-570. DOI: 10.1002/Bit.260420503 |
0.309 |
|
| 1993 |
Fu J, Wilson DB, Shuler ML. Continuous, high level production and excretion of a plasmid-encoded protein by Escherichia coli in a two-stage chemostat Biotechnology and Bioengineering. 41: 937-946. DOI: 10.1002/Bit.260411004 |
0.306 |
|
| 1992 |
Wickham TJ, Shuler ML, Hammer DA, Granados RR, Wood HA. Equilibrium and kinetic analysis of Autographa californica nuclear polyhedrosis virus attachment to different insect cell lines. The Journal of General Virology. 73: 3185-94. PMID 1469356 DOI: 10.1099/0022-1317-73-12-3185 |
0.327 |
|
| 1992 |
Wu P, Ray NG, Shuler ML. A single-cell model for CHO cells Annals of the New York Academy of Sciences. 665: 152-187. PMID 1416601 DOI: 10.1111/J.1749-6632.1992.Tb42583.X |
0.403 |
|
| 1992 |
Wickham TJ, Davis T, Granados RR, Shuler ML, Wood HA. Screening of insect cell lines for the production of recombinant proteins and infectious virus in the baculovirus expression system. Biotechnology Progress. 8: 391-6. PMID 1369220 DOI: 10.1021/Bp00017A003 |
0.398 |
|
| 1992 |
Fu J, Togna AP, Shuler ML, Wilson DB. Escherichia coli host cell modifications in continuous culture affecting heterologous protein overproduction: a population dynamics study. Biotechnology Progress. 8: 340-6. PMID 1368455 DOI: 10.1021/Bp00016A011 |
0.392 |
|
| 1992 |
Wang P, Granados RR, Shuler ML. Studies on serum-free culture of insect cells for virus propagation and recombinant protein production Journal of Invertebrate Pathology. 59: 46-53. DOI: 10.1016/0022-2011(92)90110-P |
0.392 |
|
| 1992 |
Shu J, Shuler ML. Amino acid supplementation decreases plasmid retention in Escherichia coli Biotechnology and Bioengineering. 40: 1197-1202. DOI: 10.1002/Bit.260401009 |
0.334 |
|
| 1991 |
Hirasuna TJ, Shuler ML, Lackney VK, Spanswick RM. Enhanced anthocyanin production in grape cell cultures Plant Science. 78: 107-120. DOI: 10.1016/0168-9452(91)90167-7 |
0.378 |
|
| 1991 |
Ogonah O, Shuler ML, Granados RR. Protein production (β-galactosidase) from a baculovirus vector in Spodoptera frugiperda and Trichpolusia ni cells in suspension culture Biotechnology Letters. 13: 265-270. DOI: 10.1007/Bf01041482 |
0.419 |
|
| 1991 |
Lee CWT, Shuler ML. Different shake flask closures alter gas phase composition and ajmalicine production in Catharanthus roseus cell suspensions Biotechnology Techniques. 5: 173-178. DOI: 10.1007/Bf00152776 |
0.33 |
|
| 1991 |
Gee Kim B, Shuler ML. Kinetic analysis of the effects of plasmid multimerization on segregational instability of ColE1 type plasmids in Escherichia coli B/r Biotechnology and Bioengineering. 37: 1076-1086. DOI: 10.1002/Bit.260371113 |
0.38 |
|
| 1990 |
Shuler ML, Cho T, Wickham T, Ogonah O, Kool M, Hammer DA, Granados RR, Wood HA. Bioreactor development for production of viral pesticides or heterologous proteins in insect cell cultures. Annals of the New York Academy of Sciences. 589: 399-422. PMID 2192663 DOI: 10.1111/J.1749-6632.1990.Tb24260.X |
0.406 |
|
| 1990 |
Chalmers JJ, Kim E, Telford JN, Wong EY, Tacon WC, Shuler ML, Wilson DB. Effects of temperature on Escherichia coli overproducing beta-lactamase or human epidermal growth factor. Applied and Environmental Microbiology. 56: 104-11. PMID 2155574 DOI: 10.1128/Aem.56.1.104-111.1990 |
0.544 |
|
| 1990 |
Chalmers JJ, Kim E, Telford JN, Wong EY, Tacon WC, Shuler ML, Wilson DB. Effects of temperature on Escherichia coli overproducing beta-lactamase or human epidermal growth factor. Applied and Environmental Microbiology. 56: 104-111. DOI: 10.1128/aem.56.1.104-111.1990 |
0.452 |
|
| 1990 |
Hsieh KM, Lion LW, Shuler ML. Production of extracellular and cell-associated biopolymers by Pseudomonas atlantica Biotechnology Letters. 12: 449-454. DOI: 10.1007/Bf01024403 |
0.328 |
|
| 1990 |
Chalmers JJ, Shuler ML, Wilson DB. A simple membrane reactor to obtain high cell density and plasmid encoded protein production from Escherichiacoli Biotechnology Techniques. 4: 73-78. DOI: 10.1007/Bf00163276 |
0.577 |
|
| 1990 |
Lackney VK, Spanswick RM, Hirasuna TJ, Shuler ML. PEG-enhanced, electric field-induced fusion of tonoplast and plasmalemma of grape protoplasts Plant Cell, Tissue and Organ Culture. 23: 107-114. DOI: 10.1007/Bf00035830 |
0.345 |
|
| 1990 |
Kim BG, Shuler ML. A structured, segregated model for genetically modified Escherichia coli cells and its use for prediction of plasmid stability Biotechnology and Bioengineering. 36: 581-592. DOI: 10.1002/Bit.260360605 |
0.413 |
|
| 1990 |
Kim BG, Shuler ML. Analysis of pBR322 replication kinetics and its dependency on growth rate Biotechnology and Bioengineering. 36: 233-242. DOI: 10.1002/Bit.260360304 |
0.313 |
|
| 1989 |
Asada M, Shuler ML. Stimulation of ajmalicine production and excretion from Catharanthus roseus: effects of adsorption in situ, elicitors and alginate immobilization Applied Microbiology and Biotechnology. 30: 475-481. DOI: 10.1007/Bf00263851 |
0.365 |
|
| 1989 |
Shu J, Shuler ML. Mathematical model for the growth of a single cell of E. coli on a glucose/glutamine/ammonium medium Biotechnology and Bioengineering. 33: 1117-1126. DOI: 10.1002/Bit.260330907 |
0.371 |
|
| 1988 |
Georgiou G, Palumbo T, Wilson DB, Shuler ML. Effect of alkaline medium on the production and excretion of B-lactamase by Escherichia coli Biotechnology Letters. 10: 377-382. DOI: 10.1007/Bf01087432 |
0.464 |
|
| 1987 |
Kim BG, Good TA, Ataai MM, Shuler ML. Growth behavior and prediction of copy number and retention of ColE1-type plasmids in E. coli under slow growth conditions. Annals of the New York Academy of Sciences. 506: 384-95. PMID 2449112 DOI: 10.1111/J.1749-6632.1987.Tb23835.X |
0.609 |
|
| 1987 |
Ataai MM, Shuler ML. MATHEMATICAL MODEL FOR PREDICTION OF PLASMID COPY NUMBER AND GENETIC STABILITY IN ESCHERICHIA COLI Biotechnology and Bioengineering. 30: 389-397. DOI: 10.1002/Bit.260300310 |
0.673 |
|
| 1986 |
Georgiou G, Telford JN, Shuler ML, Wilson DB. Localization of inclusion bodies in Escherichia coli overproducing β-lactamase or alkaline phosphatase Applied and Environmental Microbiology. 52: 1157-1161. PMID 3539017 DOI: 10.1128/Aem.52.5.1157-1161.1986 |
0.419 |
|
| 1986 |
Ataai MM, Shuler ML. Mathematical model for the control of ColE1 type plasmid replication Plasmid. 16: 204-212. PMID 2433706 DOI: 10.1016/0147-619X(86)90058-2 |
0.578 |
|
| 1986 |
SHULER ML, HALLSBY GA, PYNE JW, CHO T. Bioreactors for Immobilized Plant Cell Cultures Annals of the New York Academy of Sciences. 469: 270-278. DOI: 10.1111/J.1749-6632.1986.Tb26504.X |
0.342 |
|
| 1985 |
Georgiou G, Chalmers JJ, Shuler ML, Wilson DB. Continuous Immobilized Recombinant Protein Production from E. coli Capable of Selective Protein Excretion: A Feasibility Study. Biotechnology Progress. 1: 75-9. PMID 20568139 DOI: 10.1002/Btpr.5420010114 |
0.594 |
|
| 1985 |
Schmidt SK, Alexander M, Shuler ML. Predicting threshold concentrations of organic substrates for bacterial growth Journal of Theoretical Biology. 114: 1-8. DOI: 10.1016/S0022-5193(85)80250-2 |
0.321 |
|
| 1985 |
Ataai MM, Shuler ML. Simulation of CFSTR through development of a mathematical model for anaerobic growth of Escherichia coli cell population Biotechnology and Bioengineering. 27: 1051-1055. DOI: 10.1002/Bit.260270717 |
0.667 |
|
| 1985 |
Ataai MM, Shuler ML. Simulation of the growth pattern of a single cell of Escherichia coli under anaerobic conditions Biotechnology and Bioengineering. 27: 1027-1035. DOI: 10.1002/Bit.260270714 |
0.683 |
|
| 1985 |
Ataai MM, Shuler ML. MATHEMATICAL MODEL FOR PREDICTION OF COPY NUMBER AND PROTEIN PRODUCTION IN E. COLI Annual Meeting - American Institute of Chemical Engineers. |
0.654 |
|
| 1985 |
Georgiou G, Chalmers JJ, Shuler ML, Wilson DB. CONTINUOUS IMMOBILIZED RECOMBINANT PROTEIN PRODUCTION FROM E. COLI CAPABLE OF SELECTIVE PROTEIN EXCRETION: A FEASIBILITY STUDY Biotechnology Progress. 1: 75-79. |
0.509 |
|
| 1984 |
Domach MM, Leung SK, Cahn RE, Cocks GG, Shuler ML. Computer model for glucose-limited growth of a single cell of Escherichia coli B/r-A. Biotechnology and Bioengineering. 26: 1140. PMID 18553544 DOI: 10.1002/bit.260260925 |
0.617 |
|
| 1984 |
Domach MM, Shuler ML. A finite representation model for an asynchronous culture of E. coli. Biotechnology and Bioengineering. 26: 877-84. PMID 18553472 DOI: 10.1002/Bit.260260810 |
0.7 |
|
| 1984 |
Domach MM, Leung SK, Cahn RE, Cocks GG, Shuler ML. Computer model for glucose-limited growth of a single cell of Escherichia coli B/r-A. Biotechnology and Bioengineering. 26: 203-16. PMID 18551728 DOI: 10.1002/Bit.260260303 |
0.673 |
|
| 1984 |
Domach MM, Shuler ML. Testing of a potential mechanism for E. coli temporal cycle imprecision with a structural model. Journal of Theoretical Biology. 106: 577-85. PMID 6200732 DOI: 10.1016/0022-5193(84)90008-0 |
0.665 |
|
| 1984 |
Shuler ML, Pyne JW, Hallsby GA. Prospects and problems in the large scale production of metabolites from plant cell tissue cultures Journal of the American Oil Chemists' Society. 61: 1724-1728. DOI: 10.1007/Bf02582136 |
0.397 |
|
| 1984 |
Lee AL, Ataai MM, Shuler ML. DOUBLE-SUBSTRATE-LIMITED GROWTH OF ESCHERICHIA COLI Biotechnology and Bioengineering. 26: 1398-1401. DOI: 10.1002/Bit.260261120 |
0.635 |
|
| 1984 |
Sahai OP, Shuler ML. ENVIRONMENTAL PARAMETERS INFLUENCING PHENOLICS PRODUCTION BY BATCH CULTURES OF NICOTIANA TABACUM Biotechnology and Bioengineering. 26: 111-120. DOI: 10.1002/Bit.260260202 |
0.344 |
|
| 1984 |
Sahai OP, Shuler ML. MULTISTAGE CONTINUOUS CULTURE TO EXAMINE SECONDARY METABOLITE FORMATION IN PLANT CELLS: PHENOLICS FROM NICOTIANA TABACUM Biotechnology and Bioengineering. 26: 27-36. DOI: 10.1002/Bit.260260107 |
0.324 |
|
| 1984 |
Domach MM, Shuler ML. A finite representation model for an asynchronous culture of E. coli Biotechnology and Bioengineering. 26: 877-884. |
0.302 |
|
| 1984 |
Shuler ML, Ataai MM, Good TA. COMPUTER MODELS OF INDIVIDUAL BACTERIAL CELLS: A POSSIBLE TOOL FOR TESTING BIOCHEMICAL HYPOTHESES Annual Meeting - American Institute of Chemical Engineers. |
0.658 |
|
| 1984 |
Frohlich BT, Webster IA, Ataai MM, Shuler ML. PHOTOBIOREACTORS: MODELS FOR INTERACTION OF LIGHT INTENSITY, REACTOR DESIGN, AND ALGAL PHYSIOLOGY Biotechnology and Bioengineering Symposium. 331-350. |
0.563 |
|
| 1981 |
Webster IA, Shuler ML. Whole-cell hollow-fiber reactor: Transient substrate concentration profiles Biotechnology and Bioengineering. 23: 447-450. DOI: 10.1002/Bit.260230220 |
0.303 |
|
| 1980 |
Kargi F, Shuler ML, Vashon R, Seeley HW, Henry A, Austic RE. Continuous aerobic conversion of poultry waste into single-cell protein using a single reactor: Kinetic analysis and determination of optimal conditions Biotechnology and Bioengineering. 22: 1567-1600. DOI: 10.1002/Bit.260220805 |
0.304 |
|
| 1979 |
Shuler ML, Leung S, Dick CC. A MATHEMATICAL MODEL FOR THE GROWTH OF A SINGLE BACTERIAL CELL Annals of the New York Academy of Sciences. 326: 35-52. DOI: 10.1111/J.1749-6632.1979.Tb14150.X |
0.357 |
|
| 1979 |
Webster IA, Shuler ML, Rony PR. Whole‐cell hollow‐fiber reactor: Effectiveness factors Biotechnology and Bioengineering. 21: 1725-1748. DOI: 10.1002/Bit.260211004 |
0.306 |
|
| 1978 |
Webster IA, Shuler ML. Mathematical models for hollow-fiber enzyme reactors Biotechnology and Bioengineering. 20: 1541-1556. DOI: 10.1002/Bit.260201004 |
0.316 |
|
| 1978 |
Kan JK, Shuler ML. Urocanic acid production using whole cells immobilized in a hollow fiber reactor Biotechnology and Bioengineering. 20: 217-230. DOI: 10.1002/Bit.260200205 |
0.325 |
|
| 1975 |
Shuler ML, Tsuchiya HM. Cell size as an indicator of changes in intracellular composition of Azotobacter vinelandii. Canadian Journal of Microbiology. 21: 927-35. PMID 1148938 |
0.638 |
|
| 1975 |
Shuler ML, Tsuchiya HM. Determination of cell numbers and cell size for Thiobacillus ferrooxidans by the electrical resistance method Biotechnology and Bioengineering. 17: 621-624. |
0.634 |
|
| 1973 |
Shuler ML, Tsuchiya HM, Aris R. Diffusive and electrostatic effects with insolubilized enzymes subject to substrate inhibition. Journal of Theoretical Biology. 41: 347-56. PMID 4201613 DOI: 10.1016/0022-5193(73)90123-9 |
0.656 |
|
| 1972 |
Shuler ML, Aris R, Tsuchiya HM. Hydrodynamic focusing and electronic cell-sizing techniques. Applied Microbiology. 24: 384-8. PMID 16349933 |
0.672 |
|
| 1972 |
Shuler ML, Aris R, Tsuchiya HM. Diffusive and electrostatic effects with insolubilized enzymes. Journal of Theoretical Biology. 35: 67-76. PMID 5044831 DOI: 10.1016/0022-5193(72)90192-0 |
0.652 |
|
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