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Philippe Gros - Publications

Affiliations: 
McGill University, Montreal, QC, Canada 
Area:
Immunology, Microbiology Biology
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287 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Belle JI, Wang H, Fiore A, Petrov JC, Lin YH, Feng CH, Nguyen TTM, Tung J, Campeau PM, Behrends U, Brunet T, Leszinski GS, Gros P, Langlais D, Nijnik A. MYSM1 maintains ribosomal protein gene expression in hematopoietic stem cells to prevent hematopoietic dysfunction. Jci Insight. 5. PMID 32641579 DOI: 10.1172/Jci.Insight.125690  0.373
2020 Olivier JF, Fodil N, Al Habyan S, Gopal A, Artusa P, Mandl JN, McCaffrey L, Gros P. CCDC88B is required for mobility and inflammatory functions of dendritic cells. Journal of Leukocyte Biology. PMID 32480428 DOI: 10.1002/Jlb.3A0420-386R  0.342
2020 Salem S, Salem D, Gros P. Role of IRF8 in immune cells functions, protection against infections, and susceptibility to inflammatory diseases. Human Genetics. PMID 32232558 DOI: 10.1007/S00439-020-02154-2  0.357
2020 Derish I, Lee JKH, Wong-King-Cheong M, Babayeva S, Caplan J, Leung V, Shahinian C, Gravel M, Deans MR, Gros P, Torban E. Differential role of planar cell polarity gene Vangl2 in embryonic and adult mammalian kidneys. Plos One. 15: e0230586. PMID 32203543 DOI: 10.1371/Journal.Pone.0230586  0.319
2019 Jeyakumar T, Fodil N, Van Der Kraak L, Meunier C, Cayrol R, McGregor K, Langlais D, Greenwood CMT, Beauchemin N, Gros P. Inactivation of Interferon Regulatory Factor 1 Causes Susceptibility to Colitis-Associated Colorectal Cancer. Scientific Reports. 9: 18897. PMID 31827213 DOI: 10.1038/S41598-019-55378-2  0.305
2019 Kennedy JM, Georges A, Bassenden AV, Vidal SM, Berghuis AM, Taniuchi I, Majewski J, Lathrop M, Behr MA, Langlais D, Gros P. ZBTB7B (ThPOK) IS REQUIRED FOR PATHOGENESIS OF CEREBRAL MALARIA AND PROTECTION AGAINST PULMONARY TUBERCULOSIS. Infection and Immunity. PMID 31792077 DOI: 10.1128/Iai.00845-19  0.415
2019 Jeyakumar T, Beauchemin N, Gros P. Impact of the Microbiome on the Human Genome. Trends in Parasitology. PMID 31451407 DOI: 10.1016/J.Pt.2019.07.015  0.301
2018 Kong XF, Martinez-Barricarte R, Kennedy J, Mele F, Lazarov T, Deenick EK, Ma CS, Breton G, Lucero KB, Langlais D, Bousfiha A, Aytekin C, Markle J, Trouillet C, Jabot-Hanin F, ... ... Gros P, et al. Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency. Nature Immunology. PMID 30127434 DOI: 10.1038/S41590-018-0178-Z  0.329
2018 Torre S, Langlais D, Gros P. Genetic analysis of cerebral malaria in the mouse model infected with Plasmodium berghei. Mammalian Genome : Official Journal of the International Mammalian Genome Society. PMID 29922917 DOI: 10.1007/S00335-018-9752-9  0.388
2018 Langlais D, Cencic R, Moradin N, Kennedy JM, Ayi K, Brown LE, Crandall I, Tarry MJ, Schmeing M, Kain KC, Porco JA, Pelletier J, Gros P. Rocaglates as dual-targeting agents for experimental cerebral malaria. Proceedings of the National Academy of Sciences of the United States of America. PMID 29463745 DOI: 10.1073/Pnas.1713000115  0.349
2017 El-Hassan AR, Leung V, Kharfallah F, Guyot MC, Allache R, Gros P, Kibar Z. Identification and characterization of a novel chemically induced allele at the planar cell polarity gene Vangl2. Mammalian Genome : Official Journal of the International Mammalian Genome Society. PMID 29063958 DOI: 10.1007/S00335-017-9721-8  0.34
2017 Fodil N, Moradin N, Leung V, Olivier JF, Radovanovic I, Jeyakumar T, Flores Molina M, McFarquhar A, Cayrol R, Bozec D, Shoukry NH, Kubo M, Dimitrieva J, Louis E, Theatre E, ... ... Gros P, et al. CCDC88B is required for pathogenesis of inflammatory bowel disease. Nature Communications. 8: 932. PMID 29030607 DOI: 10.1038/S41467-017-01381-Y  0.331
2017 Valanparambil RM, Tam M, Gros PP, Auger JP, Segura M, Gros P, Jardim A, Geary TG, Ozato K, Stevenson MM. IRF-8 regulates expansion of myeloid-derived suppressor cells and Foxp3+ regulatory T cells and modulates Th2 immune responses to gastrointestinal nematode infection. Plos Pathogens. 13: e1006647. PMID 28968468 DOI: 10.1371/Journal.Ppat.1006647  0.337
2017 Laroque A, Min-Oo G, Tam M, Ponka P, Stevenson MM, Gros P. The mouse Char10 locus regulates severity of pyruvate kinase deficiency and susceptibility to malaria. Plos One. 12: e0177818. PMID 28542307 DOI: 10.1371/Journal.Pone.0177818  0.425
2016 Langlais D, Fodil N, Gros P. Genetics of Infectious and Inflammatory Diseases: Overlapping Discoveries from Association and Exome-Sequencing Studies. Annual Review of Immunology. PMID 27912315 DOI: 10.1146/Annurev-Immunol-051116-052442  0.36
2016 Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Knobeloch KP, Healy LM, Antel J, ... ... Gros P, et al. USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation. Nature Immunology. PMID 27721430 DOI: 10.1038/Ni.3581  0.342
2016 Moradin N, Torre S, Gauthier S, Tam M, Hawari J, Vandercruyssen K, De Spiegeleer B, Fortin A, Stevenson MM, Gros P. Cysteamine broadly improves the anti-plasmodial activity of artemisinins against murine blood stage and cerebral malaria. Malaria Journal. 15: 260. PMID 27150250 DOI: 10.1186/S12936-016-1317-3  0.575
2016 Langlais D, Barreiro LB, Gros P. The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation. The Journal of Experimental Medicine. PMID 27001747 DOI: 10.1084/Jem.20151764  0.393
2016 Van Der Kraak L, Langlais D, Jothy S, Beauchemin N, Gros P. Mapping hyper-susceptibility to colitis-associated colorectal cancer in FVB/NJ mice. Mammalian Genome : Official Journal of the International Mammalian Genome Society. PMID 26979842 DOI: 10.1007/S00335-016-9625-Z  0.368
2016 Fodil N, Langlais D, Gros P. Primary Immunodeficiencies and Inflammatory Disease: A Growing Genetic Intersection. Trends in Immunology. 37: 126-40. PMID 26791050 DOI: 10.1016/J.It.2015.12.006  0.357
2015 van Bruggen R, Gualtieri C, Iliescu A, Louicharoen Cheepsunthorn C, Mungkalasut P, Trape JF, Modiano D, Sodiomon Sirima B, Singhasivanon P, Lathrop M, Sakuntabhai A, Bureau JF, Gros P. Modulation of Malaria Phenotypes by Pyruvate Kinase (PKLR) Variants in a Thai Population. Plos One. 10: e0144555. PMID 26658699 DOI: 10.1371/Journal.Pone.0144555  0.399
2015 Belle JI, Langlais D, Petrov JC, Pardo M, Jones RG, Gros P, Nijnik A. p53 mediates loss of hematopoietic stem cell function and lymphopenia in Mysm1 deficiency. Blood. 125: 2344-8. PMID 25710881 DOI: 10.1182/Blood-2014-05-574111  0.322
2015 Torre S, Faucher SP, Fodil N, Bongfen SE, Berghout J, Schwartzentruber JA, Majewski J, Lathrop M, Cooper AM, Vidal SM, Gros P. THEMIS is required for pathogenesis of cerebral malaria and protection against pulmonary tuberculosis. Infection and Immunity. 83: 759-68. PMID 25452553 DOI: 10.1128/Iai.02586-14  0.393
2015 Rocque BL, Babayeva S, Li J, Leung V, Nezvitsky L, Cybulsky AV, Gros P, Torban E. Deficiency of the planar cell polarity protein Vangl2 in podocytes affects glomerular morphogenesis and increases susceptibility to injury. Journal of the American Society of Nephrology : Jasn. 26: 576-86. PMID 25145929 DOI: 10.1681/Asn.2014040340  0.324
2014 Fodil N, Langlais D, Moussa P, Boivin GA, Di Pietrantonio T, Radovanovic I, Dumaine A, Blanchette M, Schurr E, Gros P, Vidal SM. Specific dysregulation of IFNγ production by natural killer cells confers susceptibility to viral infection. Plos Pathogens. 10: e1004511. PMID 25473962 DOI: 10.1371/Journal.Ppat.1004511  0.394
2014 Caignard G, Eva MM, van Bruggen R, Eveleigh R, Bourque G, Malo D, Gros P, Vidal SM. Mouse ENU Mutagenesis to Understand Immunity to Infection: Methods, Selected Examples, and Perspectives. Genes. 5: 887-925. PMID 25268389 DOI: 10.3390/genes5040887  0.312
2014 Salem S, Langlais D, Lefebvre F, Bourque G, Bigley V, Haniffa M, Casanova JL, Burk D, Berghuis A, Butler KM, Leahy TR, Hambleton S, Gros P. Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8(K108E) mutation. Blood. 124: 1894-904. PMID 25122610 DOI: 10.1182/Blood-2014-04-570879  0.304
2014 Iliescu A, Gravel M, Horth C, Gros P. Independent mutations at Arg181 and Arg274 of Vangl proteins that are associated with neural tube defects in humans decrease protein stability and impair membrane targeting. Biochemistry. 53: 5356-64. PMID 25068569 DOI: 10.1021/Bi500400G  0.335
2014 Radovanovic I, Leung V, Iliescu A, Bongfen SE, Mullick A, Langlais D, Gros P. Genetic control of susceptibility to Candida albicans in SM/J mice. Journal of Immunology (Baltimore, Md. : 1950). 193: 1290-300. PMID 24973457 DOI: 10.4049/Jimmunol.1400783  0.431
2014 Dauphinee SM, Richer E, Eva MM, McIntosh F, Paquet M, Dangoor D, Burkart C, Zhang DE, Gruenheid S, Gros P, Behr M, Malo D. Contribution of increased ISG15, ISGylation and deregulated type I IFN signaling in Usp18 mutant mice during the course of bacterial infections. Genes and Immunity. 15: 282-92. PMID 24807690 DOI: 10.1038/Gene.2014.17  0.636
2013 Berghout J, Langlais D, Radovanovic I, Tam M, MacMicking JD, Stevenson MM, Gros P. Irf8-regulated genomic responses drive pathological inflammation during cerebral malaria. Plos Pathogens. 9: e1003491. PMID 23853600 DOI: 10.1371/Journal.Ppat.1003491  0.419
2013 Torre S, van Bruggen R, Kennedy JM, Berghout J, Bongfen SE, Langat P, Lathrop M, Vidal SM, Gros P. Susceptibility to lethal cerebral malaria is regulated by epistatic interaction between chromosome 4 (Berr6) and chromosome 1 (Berr7) loci in mice. Genes and Immunity. 14: 249-57. PMID 23594960 DOI: 10.1038/gene.2013.16  0.339
2013 Meunier C, Van Der Kraak L, Turbide C, Groulx N, Labouba I, Cingolani P, Blanchette M, Yeretssian G, Mes-Masson AM, Saleh M, Beauchemin N, Gros P. Positional mapping and candidate gene analysis of the mouse Ccs3 locus that regulates differential susceptibility to carcinogen-induced colorectal cancer. Plos One. 8: e58733. PMID 23516545 DOI: 10.1371/Journal.Pone.0058733  0.304
2013 Salem S, Gros P. Genetic determinants of susceptibility to Mycobacterial infections: IRF8, a new kid on the block. Advances in Experimental Medicine and Biology. 783: 45-80. PMID 23468103 DOI: 10.1007/978-1-4614-6111-1_3  0.319
2013 Langlais D, Gros P. 155 Cytokine. 63: 279. DOI: 10.1016/J.Cyto.2013.06.158  0.4
2012 Torban E, Iliescu A, Gros P. An expanding role of Vangl proteins in embryonic development. Current Topics in Developmental Biology. 101: 237-61. PMID 23140632 DOI: 10.1016/B978-0-12-394592-1.00005-3  0.372
2012 Bogunovic D, Byun M, Durfee LA, Abhyankar A, Sanal O, Mansouri D, Salem S, Radovanovic I, Grant AV, Adimi P, Mansouri N, Okada S, Bryant VL, Kong XF, Kreins A, ... ... Gros P, et al. Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency. Science (New York, N.Y.). 337: 1684-8. PMID 22859821 DOI: 10.1126/Science.1224026  0.331
2012 Bongfen SE, Rodrigue-Gervais IG, Berghout J, Torre S, Cingolani P, Wiltshire SA, Leiva-Torres GA, Letourneau L, Sladek R, Blanchette M, Lathrop M, Behr MA, Gruenheid S, Vidal SM, Saleh M, ... Gros P, et al. An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria. Plos One. 7: e31012. PMID 22363534 DOI: 10.1371/Journal.Pone.0031012  0.629
2012 Laroque A, Min-Oo G, Tam M, Radovanovic I, Stevenson MM, Gros P. Genetic control of susceptibility to infection with Plasmodium chabaudi chabaudi AS in inbred mouse strains. Genes and Immunity. 13: 155-63. PMID 21975430 DOI: 10.1038/Gene.2011.67  0.423
2011 Ramirez-Aquino R, Radovanovic I, Fortin A, Sciutto-Conde E, Fragoso-González G, Gros P, Aguilar-Delfin I. Identification of loci controlling restriction of parasite growth in experimental Taenia crassiceps cysticercosis. Plos Neglected Tropical Diseases. 5: e1435. PMID 22206032 DOI: 10.1371/Journal.Pntd.0001435  0.648
2011 Seo JH, Zilber Y, Babayeva S, Liu J, Kyriakopoulos P, De Marco P, Merello E, Capra V, Gros P, Torban E. Mutations in the planar cell polarity gene, Fuzzy, are associated with neural tube defects in humans. Human Molecular Genetics. 20: 4324-33. PMID 21840926 DOI: 10.1093/Hmg/Ddr359  0.323
2011 Mullick A, Tremblay J, Leon Z, Gros P. A novel role for the fifth component of complement (C5) in cardiac physiology. Plos One. 6: e22919. PMID 21829669 DOI: 10.1371/Journal.Pone.0022919  0.328
2011 Fortier A, Faucher SP, Diallo K, Gros P. Global cellular changes induced by Legionella pneumophila infection of bone marrow-derived macrophages. Immunobiology. 216: 1274-85. PMID 21794945 DOI: 10.1016/J.Imbio.2011.06.008  0.413
2011 Marquis JF, Kapoustina O, Langlais D, Ruddy R, Dufour CR, Kim BH, MacMicking JD, Giguère V, Gros P. Interferon regulatory factor 8 regulates pathways for antigen presentation in myeloid cells and during tuberculosis. Plos Genetics. 7: e1002097. PMID 21731497 DOI: 10.1371/Journal.Pgen.1002097  0.383
2011 Meunier C, Kwan T, Turbide C, Beauchemin N, Gros P. Genetic control of susceptibility to carcinogen-induced colorectal cancer in mice: the Ccs3 and Ccs5 loci regulate different aspects of tumorigenesis. Cell Cycle (Georgetown, Tex.). 10: 1739-49. PMID 21543896 DOI: 10.4161/Cc.10.11.15817  0.554
2011 Radovanovic I, Mullick A, Gros P. Genetic control of susceptibility to infection with Candida albicans in mice. Plos One. 6: e18957. PMID 21533108 DOI: 10.1371/Journal.Pone.0018957  0.42
2011 Hambleton S, Salem S, Bustamante J, Bigley V, Boisson-Dupuis S, Azevedo J, Fortin A, Haniffa M, Ceron-Gutierrez L, Bacon CM, Menon G, Trouillet C, McDonald D, Carey P, Ginhoux F, ... ... Gros P, et al. IRF8 mutations and human dendritic-cell immunodeficiency. The New England Journal of Medicine. 365: 127-38. PMID 21524210 DOI: 10.1056/Nejmoa1100066  0.597
2011 Min-Oo G, Gros P. Genetic analysis in mice identifies cysteamine as a novel partner for artemisinin in the treatment of malaria. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 22: 486-94. PMID 21437649 DOI: 10.1007/S00335-011-9316-8  0.391
2011 Guyot MC, Bosoi CM, Kharfallah F, Reynolds A, Drapeau P, Justice M, Gros P, Kibar Z. A novel hypomorphic Looptail allele at the planar cell polarity Vangl2 gene. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 240: 839-49. PMID 21404367 DOI: 10.1002/Dvdy.22577  0.312
2011 Iliescu A, Gravel M, Horth C, Apuzzo S, Gros P. Transmembrane topology of mammalian planar cell polarity protein Vangl1. Biochemistry. 50: 2274-82. PMID 21291170 DOI: 10.1021/Bi101767A  0.334
2011 Iliescu A, Gravel M, Horth C, Kibar Z, Gros P. Loss of membrane targeting of Vangl proteins causes neural tube defects. Biochemistry. 50: 795-804. PMID 21142127 DOI: 10.1021/Bi101286D  0.362
2011 Longley R, Smith C, Fortin A, Berghout J, McMorran B, Burgio G, Foote S, Gros P. Host resistance to malaria: using mouse models to explore the host response. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 22: 32-42. PMID 21116636 DOI: 10.1007/S00335-010-9302-6  0.616
2011 Kibar Z, Salem S, Bosoi CM, Pauwels E, De Marco P, Merello E, Bassuk AG, Capra V, Gros P. Contribution of VANGL2 mutations to isolated neural tube defects. Clinical Genetics. 80: 76-82. PMID 20738329 DOI: 10.1111/J.1399-0004.2010.01515.X  0.319
2010 Van Der Kraak L, Meunier C, Turbide C, Jothy S, Gaboury L, Marcus V, Chang SY, Beauchemin N, Gros P. A two-locus system controls susceptibility to colitis-associated colon cancer in mice. Oncotarget. 1: 436-46. PMID 21311099 DOI: 10.18632/Oncotarget.177  0.359
2010 Gruenheid S, Gros P. Forward genetic dissection of innate response to infection in inbred mouse strains: selected success stories. Clinical and Experimental Immunology. 162: 393-401. PMID 21070206 DOI: 10.1111/J.1365-2249.2010.04249.X  0.644
2010 Min-Oo G, Fortin A, Poulin JF, Gros P. Cysteamine, the molecule used to treat cystinosis, potentiates the antimalarial efficacy of artemisinin. Antimicrobial Agents and Chemotherapy. 54: 3262-70. PMID 20479197 DOI: 10.1128/Aac.01719-09  0.587
2010 Stevenson MM, Gros P, Olivier M, Fortin A, Serghides L. Cerebral malaria: human versus mouse studies. Trends in Parasitology. 26: 274-5. PMID 20382077 DOI: 10.1016/J.Pt.2010.03.008  0.55
2010 Gravel M, Iliescu A, Horth C, Apuzzo S, Gros P. Molecular and cellular mechanisms underlying neural tube defects in the loop-tail mutant mouse Biochemistry. 49: 3445-3455. PMID 20329788 DOI: 10.1021/Bi902180M  0.375
2010 Min-Oo G, Ayi K, Bongfen SE, Tam M, Radovanovic I, Gauthier S, Santiago H, Rothfuchs AG, Roffê E, Sher A, Mullick A, Fortin A, Stevenson MM, Kain KC, Gros P. Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium. Experimental Parasitology. 125: 315-24. PMID 20219464 DOI: 10.1016/J.Exppara.2010.02.009  0.556
2010 Reynolds A, McDearmid JR, Lachance S, De Marco P, Merello E, Capra V, Gros P, Drapeau P, Kibar Z. VANGL1 rare variants associated with neural tube defects affect convergent extension in zebrafish. Mechanisms of Development. 127: 385-92. PMID 20043994 DOI: 10.1016/J.Mod.2009.12.002  0.37
2010 Meunier C, Cai J, Fortin A, Kwan T, Marquis JF, Turbide C, Van Der Kraak L, Jothy S, Beauchemin N, Gros P. Characterization of a major colon cancer susceptibility locus (Ccs3) on mouse chromosome 3 Oncogene. 29: 647-661. PMID 19915610 DOI: 10.1200/Jco.2010.28.15_Suppl.1548  0.654
2010 Min-Oo G, Willemetz A, Tam M, Canonne-Hergaux F, Stevenson MM, Gros P. Mapping of Char10, a novel malaria susceptibility locus on mouse chromosome 9 Genes and Immunity. 11: 113-123. PMID 19865104 DOI: 10.1038/Gene.2009.78  0.455
2010 Berghout J, Min-Oo G, Tam M, Gauthier S, Stevenson MM, Gros P. Identification of a novel cerebral malaria susceptibility locus (Berr5) on mouse chromosome 19. Genes and Immunity. 11: 310-8. PMID 19865103 DOI: 10.1038/Gene.2009.79  0.428
2009 Schurr E, Gros P. A common genetic fingerprint in leprosy and Crohn's disease? The New England Journal of Medicine. 361: 2666-8. PMID 20018963 DOI: 10.1056/Nejme0910690  0.352
2009 Bongfen SE, Laroque A, Berghout J, Gros P. Genetic and genomic analyses of host-pathogen interactions in malaria. Trends in Parasitology. 25: 417-22. PMID 19717339 DOI: 10.1016/J.Pt.2009.05.012  0.356
2009 Czachorowski M, Lam-Yuk-Tseung S, Cellier M, Gros P. Transmembrane topology of the mammalian Slc11a2 iron transporter. Biochemistry. 48: 8422-34. PMID 19621945 DOI: 10.1021/Bi900606Y  0.359
2009 Kibar Z, Bosoi CM, Kooistra M, Salem S, Finnell RH, De Marco P, Merello E, Bassuk AG, Capra V, Gros P. Novel mutations in VANGL1 in neural tube defects. Human Mutation. 30: E706-15. PMID 19319979 DOI: 10.1002/Humu.21026  0.307
2009 Marquis JF, Lacourse R, Ryan L, North RJ, Gros P. Genetic and functional characterization of the mouse Trl3 locus in defense against tuberculosis. Journal of Immunology (Baltimore, Md. : 1950). 182: 3757-67. PMID 19265154 DOI: 10.4049/Jimmunol.0802094  0.413
2009 Marquis JF, LaCourse R, Ryan L, North RJ, Gros P. Disseminated and rapidly fatal tuberculosis in mice bearing a defective allele at IFN regulatory factor 8. Journal of Immunology (Baltimore, Md. : 1950). 182: 3008-15. PMID 19234196 DOI: 10.4049/Jimmunol.0800680  0.375
2009 Cai J, Lian XJ, Roretz Cv, Shustik C, Gallouzi I, Gros P. Characterization of Bortezomib (Velcade ™) Resistance in a New Set of Human Cell Lines Obtained by Stepwise Selection. Blood. 114: 2741-2741. DOI: 10.1182/Blood.V114.22.2741.2741  0.315
2008 Divangahi M, Mostowy S, Coulombe F, Kozak R, Guillot L, Veyrier F, Kobayashi KS, Flavell RA, Gros P, Behr MA. NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity. Journal of Immunology (Baltimore, Md. : 1950). 181: 7157-65. PMID 18981137 DOI: 10.4049/Jimmunol.181.10.7157  0.373
2008 Marquis JF, Gros P. Genetic analysis of resistance to infections in mice: A/J meets C57BL/6J Current Topics in Microbiology and Immunology. 321: 27-57. PMID 18727486 DOI: 10.1007/978-3-540-75203-5_2  0.458
2008 Zhang AS, Canonne-Hergaux F, Gruenheid S, Gros P, Ponka P. Use of Nramp2-transfected Chinese hamster ovary cells and reticulocytes from mk/mk mice to study iron transport mechanisms. Experimental Hematology. 36: 1227-35. PMID 18722041 DOI: 10.1016/J.Exphem.2008.04.014  0.568
2008 Carrier I, Gros P. Investigating the role of the invariant carboxylate residues E552 and E1197 in the catalytic activity of Abcb1a (mouse Mdr3). The Febs Journal. 275: 3312-24. PMID 18489584 DOI: 10.1111/J.1742-4658.2008.06479.X  0.306
2008 Valdez Y, Diehl GE, Vallance BA, Grassl GA, Guttman JA, Brown NF, Rosenberger CM, Littman DR, Gros P, Finlay BB. Nramp1 expression by dendritic cells modulates inflammatory responses during Salmonella Typhimurium infection. Cellular Microbiology. 10: 1646-61. PMID 18397382 DOI: 10.1111/J.1462-5822.2008.01155.X  0.352
2008 Cai J, Damaraju VL, Groulx N, Mowles D, Peng Y, Robins MJ, Cass CE, Gros P. Two distinct molecular mechanisms underlying cytarabine resistance in human leukemic cells. Cancer Research. 68: 2349-57. PMID 18381442 DOI: 10.1158/0008-5472.Can-07-5528  0.364
2008 Torban E, Patenaude AM, Leclerc S, Rakowiecki S, Gauthier S, Andelfinger G, Epstein DJ, Gros P. Genetic interaction between members of the Vangl family causes neural tube defects in mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 3449-54. PMID 18296642 DOI: 10.1073/Pnas.0712126105  0.356
2008 Min-Oo G, Lindqvist L, Vaglenov A, Wang C, Fortin P, Li Y, Kaltenboeck B, Gros P. Genetic control of susceptibility to pulmonary infection with Chlamydia pneumoniae in the mouse. Genes and Immunity. 9: 383-8. PMID 18075514 DOI: 10.1038/Sj.Gene.6364450  0.414
2008 Marquis JF, Nantel A, LaCourse R, Ryan L, North RJ, Gros P. Fibrotic response as a distinguishing feature of resistance and susceptibility to pulmonary infection with Mycobacterium tuberculosis in mice. Infection and Immunity. 76: 78-88. PMID 17938213 DOI: 10.1128/Iai.00369-07  0.38
2007 Roy MF, Riendeau N, Bédard C, Hélie P, Min-Oo G, Turcotte K, Gros P, Canonne-Hergaux F, Malo D. Pyruvate kinase deficiency confers susceptibility to Salmonella typhimurium infection in mice. The Journal of Experimental Medicine. 204: 2949-61. PMID 17998386 DOI: 10.1084/jem.20062606  0.325
2007 Turcotte K, Gauthier S, Malo D, Tam M, Stevenson MM, Gros P. Icsbp1/IRF-8 is required for innate and adaptive immune responses against intracellular pathogens. Journal of Immunology (Baltimore, Md. : 1950). 179: 2467-76. PMID 17675508 DOI: 10.4049/jimmunol.179.4.2467  0.304
2007 Lamkanfi M, Amer A, Kanneganti TD, Muñoz-Planillo R, Chen G, Vandenabeele P, Fortier A, Gros P, Núñez G. The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation. Journal of Immunology (Baltimore, Md. : 1950). 178: 8022-7. PMID 17548639 DOI: 10.4049/Jimmunol.178.12.8022  0.33
2007 Min-Oo G, Stevenson MM, Fortin A, Gros P. Genetic control of host-pathogen interactions in mice. Novartis Foundation Symposium. 281: 156-65; discussion 1. PMID 17534072 DOI: 10.1002/9780470062128.Ch13  0.661
2007 Fortin A, Diez E, Henderson JE, Mogil JS, Gros P, Skamene E. The AcB/BcA recombinant congenic strains of mice: strategies for phenotype dissection, mapping and cloning of quantitative trait genes. Novartis Foundation Symposium. 281: 141-53; discussion 1. PMID 17534071 DOI: 10.1002/9780470062128.Ch12  0.615
2007 Fortin A, Abel L, Casanova JL, Gros P. Host genetics of mycobacterial diseases in mice and men: forward genetic studies of BCG-osis and tuberculosis. Annual Review of Genomics and Human Genetics. 8: 163-92. PMID 17492906 DOI: 10.1146/Annurev.Genom.8.080706.092315  0.788
2007 Kibar Z, Capra V, Gros P. Toward understanding the genetic basis of neural tube defects. Clinical Genetics. 71: 295-310. PMID 17470131 DOI: 10.1111/J.1399-0004.2007.00793.X  0.341
2007 Min-Oo G, Tam M, Stevenson MM, Gros P. Pyruvate kinase deficiency: correlation between enzyme activity, extent of hemolytic anemia and protection against malaria in independent mouse mutants. Blood Cells, Molecules & Diseases. 39: 63-9. PMID 17466543 DOI: 10.1016/J.Bcmd.2007.03.003  0.403
2007 Kibar Z, Torban E, McDearmid JR, Reynolds A, Berghout J, Mathieu M, Kirillova I, De Marco P, Merello E, Hayes JM, Wallingford JB, Drapeau P, Capra V, Gros P. Mutations in VANGL1 associated with neural-tube defects. The New England Journal of Medicine. 356: 1432-7. PMID 17409324 DOI: 10.1056/Nejmoa060651  0.315
2007 Min-Oo G, Fortin A, Pitari G, Tam M, Stevenson MM, Gros P. Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus. The Journal of Experimental Medicine. 204: 511-24. PMID 17312006 DOI: 10.1084/Jem.20061252  0.613
2007 Carrier I, Urbatsch IL, Senior AE, Gros P. Mutational analysis of conserved aromatic residues in the A-loop of the ABC transporter ABCB1A (mouse Mdr3). Febs Letters. 581: 301-8. PMID 17214987 DOI: 10.1016/J.Febslet.2006.12.030  0.309
2007 Fortier A, de Chastellier C, Balor S, Gros P. Birc1e/Naip5 rapidly antagonizes modulation of phagosome maturation by Legionella pneumophila. Cellular Microbiology. 9: 910-23. PMID 17087731 DOI: 10.1111/J.1462-5822.2006.00839.X  0.361
2007 Torban E, Wang HJ, Patenaude AM, Riccomagno M, Daniels E, Epstein D, Gros P. Tissue, cellular and sub-cellular localization of the Vangl2 protein during embryonic development: effect of the Lp mutation. Gene Expression Patterns : Gep. 7: 346-54. PMID 16962386 DOI: 10.1016/J.Modgep.2006.07.007  0.319
2006 Turcotte K, Loredo-Osti JC, Fortin P, Schurr E, Morgan K, Gros P. Complex genetic control of susceptibility to Mycobacterium bovis (Bacille Calmette-Guérin) infection in wild-derived Mus spretus mice. Genes and Immunity. 7: 684-7. PMID 17024129 DOI: 10.1038/Sj.Gene.6364346  0.423
2006 Lam-Yuk-Tseung S, Picard V, Gros P. Identification of a tyrosine-based motif (YGSI) in the amino terminus of Nramp1 (Slc11a1) that is important for lysosomal targeting. The Journal of Biological Chemistry. 281: 31677-88. PMID 16905747 DOI: 10.1074/Jbc.M601828200  0.342
2006 Shi L, Adkins JN, Coleman JR, Schepmoes AA, Dohnkova A, Mottaz HM, Norbeck AD, Purvine SO, Manes NP, Smallwood HS, Wang H, Forbes J, Gros P, Uzzau S, Rodland KD, et al. Proteomic analysis of Salmonella enterica serovar typhimurium isolated from RAW 264.7 macrophages: identification of a novel protein that contributes to the replication of serovar typhimurium inside macrophages. The Journal of Biological Chemistry. 281: 29131-40. PMID 16893888 DOI: 10.1074/Jbc.M604640200  0.417
2006 Mullick A, Leon Z, Min-Oo G, Berghout J, Lo R, Daniels E, Gros P. Cardiac failure in C5-deficient A/J mice after Candida albicans infection. Infection and Immunity. 74: 4439-51. PMID 16861630 DOI: 10.1128/Iai.00159-06  0.317
2006 Tuite A, Gros P. The impact of genomics on the analysis of host resistance to infectious disease Microbes and Infection. 8: 1647-1653. PMID 16697229 DOI: 10.1016/J.Micinf.2005.11.016  0.383
2006 Lam-Yuk-Tseung S, Camaschella C, Iolascon A, Gros P. A novel R416C mutation in human DMT1 (SLC11A2) displays pleiotropic effects on function and causes microcytic anemia and hepatic iron overload. Blood Cells, Molecules & Diseases. 36: 347-54. PMID 16584902 DOI: 10.1016/J.Bcmd.2006.01.011  0.33
2006 Lam-Yuk-Tseung S, Gros P. Distinct targeting and recycling properties of two isoforms of the iron transporter DMT1 (NRAMP2, Slc11A2) Biochemistry. 45: 2294-2301. PMID 16475818 DOI: 10.1021/Bi052307M  0.306
2006 Kwan T, Liu J, Dubow M, Gros P, Pelletier J. Comparative genomic analysis of 18 Pseudomonas aeruginosa bacteriophages. Journal of Bacteriology. 188: 1184-7. PMID 16428425 DOI: 10.1128/Jb.188.3.1184-1187.2006  0.395
2006 Canonne-Hergaux F, Donovan A, Delaby C, Wang HJ, Gros P. Comparative studies of duodenal and macrophage ferroportin proteins. American Journal of Physiology. Gastrointestinal and Liver Physiology. 290: G156-63. PMID 16081760 DOI: 10.1152/Ajpgi.00227.2005  0.333
2006 Lam-Yuk-Tseung S, Mathieu M, Gros P. Functional characterization of the E399D DMT1/NRAMP2/SLC11A2 protein produced by an exon 12 mutation in a patient with microcytic anemia and iron overload. Blood Cells, Molecules & Diseases. 35: 212-6. PMID 16023393 DOI: 10.1016/J.Bcmd.2005.05.008  0.334
2005 Lam-Yuk-Tseung S, Touret N, Grinstein S, Gros P. Carboxyl-terminus determinants of the iron transporter DMT1/SLC11A2 isoform II (-IRE/1B) mediate internalization from the plasma membrane into recycling endosomes. Biochemistry. 44: 12149-59. PMID 16142913 DOI: 10.1021/Bi050911R  0.316
2005 Tuite A, Elias M, Picard S, Mullick A, Gros P. Genetic control of susceptibility to Candida albicans in susceptible A/J and resistant C57BL/6J mice. Genes and Immunity. 6: 672-82. PMID 16079897 DOI: 10.1038/Sj.Gene.6364254  0.409
2005 Fortier A, Diez E, Gros P. Naip5/Birc1e and susceptibility to Legionella pneumophila. Trends in Microbiology. 13: 328-35. PMID 15935674 DOI: 10.1016/J.Tim.2005.05.007  0.393
2005 Min-Oo G, Gros P. Erythrocyte variants and the nature of their malaria protective effect Cellular Microbiology. 7: 753-763. PMID 15888079 DOI: 10.1111/J.1462-5822.2005.00524.X  0.381
2005 Ing R, Gros P, Stevenson MM. Interleukin-15 enhances innate and adaptive immune responses to blood-stage malaria infection in mice. Infection and Immunity. 73: 3172-7. PMID 15845528 DOI: 10.1128/Iai.73.5.3172-3177.2005  0.325
2005 Jabado N, Gros P. Tuberculosis: The genetics of vulnerability Nature. 434: 709-711. PMID 15815612 DOI: 10.1038/434709A  0.375
2005 Kwan T, Liu J, DuBow M, Gros P, Pelletier J. The complete genomes and proteomes of 27 Staphylococcus aureus bacteriophages. Proceedings of the National Academy of Sciences of the United States of America. 102: 5174-9. PMID 15788529 DOI: 10.1073/Pnas.0501140102  0.52
2005 Turcotte K, Gauthier S, Tuite A, Mullick A, Malo D, Gros P. A mutation in the Icsbp1 gene causes susceptibility to infection and a chronic myeloid leukemia-like syndrome in BXH-2 mice. The Journal of Experimental Medicine. 201: 881-90. PMID 15781580 DOI: 10.1084/jem.20042170  0.306
2005 Fortier A, Min-Oo G, Forbes J, Lam-Yuk-Tseung S, Gros P. Single gene effects in mouse models of host: pathogen interactions. Journal of Leukocyte Biology. 77: 868-77. PMID 15653750 DOI: 10.1189/Jlb.1004616  0.462
2005 Karwatsky J, Leimanis M, Cai J, Gros P, Georges E. The leucotriene C4 binding sites in multidrug resistance protein 1 (ABCC1) include the first membrane multiple spanning domain. Biochemistry. 44: 340-51. PMID 15628876 DOI: 10.1021/Bi048853H  0.319
2004 Torban E, Kor C, Gros P. Van Gogh-like2 (Strabismus) and its role in planar cell polarity and convergent extension in vertebrates. Trends in Genetics : Tig. 20: 570-7. PMID 15475117 DOI: 10.1016/J.Tig.2004.09.003  0.312
2004 Torban E, Wang HJ, Groulx N, Gros P. Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family. The Journal of Biological Chemistry. 279: 52703-13. PMID 15456783 DOI: 10.1074/Jbc.M408675200  0.374
2004 Tuite A, Mullick A, Gros P. Genetic analysis of innate immunity in resistance to Candida albicans Genes and Immunity. 5: 576-587. PMID 15372070 DOI: 10.1038/Sj.Gene.6364130  0.428
2004 Touret N, Martin-Orozco N, Paroutis P, Furuya W, Lam-Yuk-Tseung S, Forbes J, Gros P, Grinstein S. Molecular and cellular mechanisms underlying iron transport deficiency in microcytic anemia. Blood. 104: 1526-33. PMID 15155465 DOI: 10.1182/Blood-2004-02-0731  0.342
2004 Apuzzo S, Abdelhakim A, Fortin AS, Gros P. Cross-talk between the paired domain and the homeodomain of Pax3: DNA binding by each domain causes a structural change in the other domain, supporting interdependence for DNA Binding. The Journal of Biological Chemistry. 279: 33601-12. PMID 15148315 DOI: 10.1074/Jbc.M402949200  0.763
2004 Cohen ND, Harrington J, Gros P, Del Castro L, Meyer D, Martens RJ. Nramp1 deletion does not confer susceptibility to Rhodococcus equi infection in mice. Immunogenetics. 56: 65-7. PMID 15045472 DOI: 10.1007/S00251-004-0670-5  0.398
2004 Min-Oo G, Fortin A, Tam MF, Gros P, Stevenson MM. Phenotypic expression of pyruvate kinase deficiency and protection against malaria in a mouse model. Genes and Immunity. 5: 168-75. PMID 15029238 DOI: 10.1038/sj.gene.6364069  0.806
2004 Liu J, Dehbi M, Moeck G, Arhin F, Bauda P, Bergeron D, Callejo M, Ferretti V, Ha N, Kwan T, McCarty J, Srikumar R, Williams D, Wu JJ, Gros P, et al. Antimicrobial drug discovery through bacteriophage genomics. Nature Biotechnology. 22: 185-91. PMID 14716317 DOI: 10.1038/Nbt932  0.501
2004 Turcotte K, Gauthier S, Mitsos LM, Shustik C, Copeland NG, Jenkins NA, Fournet JC, Jolicoeur P, Gros P. Genetic control of myeloproliferation in BXH-2 mice. Blood. 103: 2343-50. PMID 14630819 DOI: 10.1182/Blood-2003-06-1852  0.392
2004 Kibar Z, Gauthier S, Lee SH, Vidal S, Gros P. Rescue of the neural tube defect of loop-tail mice by a BAC clone containing the Ltap gene. Genomics. 82: 397-400. PMID 12906864 DOI: 10.1016/S0888-7543(03)00113-7  0.337
2003 Min-Oo G, Fortin A, Tam MF, Nantel A, Stevenson MM, Gros P. Pyruvate kinase deficiency in mice protects against malaria. Nature Genetics. 35: 357-62. PMID 14595440 DOI: 10.1038/Ng1260  0.654
2003 Orelle C, Dalmas O, Gros P, Di Pietro A, Jault JM. The conserved glutamate residue adjacent to the Walker-B motif is the catalytic base for ATP hydrolysis in the ATP-binding cassette transporter BmrA. The Journal of Biological Chemistry. 278: 47002-8. PMID 12968023 DOI: 10.1074/Jbc.M308268200  0.325
2003 Forbes JR, Gros P. Iron, manganese, and cobalt transport by Nramp1 (Slc11a1) and Nramp2 (Slc11a2) expressed at the plasma membrane. Blood. 102: 1884-92. PMID 12750164 DOI: 10.1182/Blood-2003-02-0425  0.33
2003 Mitsos LM, Cardon LR, Ryan L, LaCourse R, North RJ, Gros P. Susceptibility to tuberculosis: a locus on mouse chromosome 19 (Trl-4) regulates Mycobacterium tuberculosis replication in the lungs. Proceedings of the National Academy of Sciences of the United States of America. 100: 6610-5. PMID 12740444 DOI: 10.1073/Pnas.1031727100  0.383
2003 Touret N, Furuya W, Forbes J, Gros P, Grinstein S. Dynamic traffic through the recycling compartment couples the metal transporter Nramp2 (DMT1) with the transferrin receptor. The Journal of Biological Chemistry. 278: 25548-57. PMID 12724326 DOI: 10.1074/Jbc.M212374200  0.307
2003 Lam-Yuk-Tseung S, Gros P. Genetic control of susceptibility to bacterial infections in mouse models Cellular Microbiology. 5: 299-313. PMID 12713489 DOI: 10.1046/J.1462-5822.2003.00276.X  0.453
2003 Jabado N, Cuellar-Mata P, Grinstein S, Gros P. Iron chelators modulate the fusogenic properties of Salmonella-containing phagosomes. Proceedings of the National Academy of Sciences of the United States of America. 100: 6127-32. PMID 12711734 DOI: 10.1073/Pnas.0937287100  0.374
2003 Karwatsky J, Daoud R, Cai J, Gros P, Georges E. Binding of a photoaffinity analogue of glutathione to MRP1 (ABCC1) within two cytoplasmic regions (L0 and L1) as well as transmembrane domains 10-11 and 16-17. Biochemistry. 42: 3286-94. PMID 12641460 DOI: 10.1021/Bi0268807  0.301
2003 Lee SH, Zafer A, de Repentigny Y, Kothary R, Tremblay ML, Gros P, Duplay P, Webb JR, Vidal SM. Transgenic expression of the activating natural killer receptor Ly49H confers resistance to cytomegalovirus in genetically susceptible mice. The Journal of Experimental Medicine. 197: 515-26. PMID 12591908 DOI: 10.1084/Jem.20021713  0.461
2003 Cai J, Gros P. Overexpression, purification, and functional characterization of ATP-binding cassette transporters in the yeast, Pichia pastoris Biochimica Et Biophysica Acta - Biomembranes. 1610: 63-76. PMID 12586381 DOI: 10.1016/S0005-2736(02)00718-6  0.356
2003 Lam-Yuk-Tseung S, Govoni G, Forbes J, Gros P. Iron transport by Nramp2/DMT1: pH regulation of transport by 2 histidines in transmembrane domain 6. Blood. 101: 3699-3707. PMID 12522007 DOI: 10.1182/Blood-2002-07-2108  0.759
2003 Diez E, Lee SH, Gauthier S, Yaraghi Z, Tremblay M, Vidal S, Gros P. Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila. Nature Genetics. 33: 55-60. PMID 12483212 DOI: 10.1038/Ng1065  0.41
2002 Zaharik ML, Vallance BA, Puente JL, Gros P, Finlay BB. Host-pathogen interactions: Host resistance factor Nramp1 up-regulates the expression of Salmonella pathogenicity island-2 virulence genes. Proceedings of the National Academy of Sciences of the United States of America. 99: 15705-10. PMID 12441401 DOI: 10.1073/Pnas.252415599  0.433
2002 Su Z, Fortin A, Gros P, Stevenson MM. Opsonin-independent phagocytosis: an effector mechanism against acute blood-stage Plasmodium chabaudi AS infection. The Journal of Infectious Diseases. 186: 1321-9. PMID 12402202 DOI: 10.1086/344576  0.6
2002 Fortin A, Stevenson MM, Gros P. Susceptibility to malaria as a complex trait: big pressure from a tiny creature. Human Molecular Genetics. 11: 2469-78. PMID 12351583 DOI: 10.1093/Hmg/11.20.2469  0.8
2002 Jabado N, Canonne-Hergaux F, Gruenheid S, Picard V, Gros P. Iron transporter Nramp2/DMT-1 is associated with the membrane of phagosomes in macrophages and Sertoli cells. Blood. 100: 2617-22. PMID 12239176 DOI: 10.1182/Blood-2002-04-1182  0.648
2002 Frehel C, Canonne-Hergaux F, Gros P, De Chastellier C. Effect of Nramp1 on bacterial replication and on maturation of Mycobacterium avium-containing phagosomes in bone marrow-derived mouse macrophages. Cellular Microbiology. 4: 541-56. PMID 12174088 DOI: 10.1046/J.1462-5822.2002.00213.X  0.374
2002 Canonne-Hergaux F, Gros P. Expression of the iron transporter DMT1 in kidney from normal and anemic mk mice Kidney International. 62: 147-156. PMID 12081573 DOI: 10.1046/J.1523-1755.2002.00405.X  0.346
2002 Canonne-Hergaux F, Calafat J, Richer E, Cellier M, Grinstein S, Borregaard N, Gros P. Expression and subcellular localization of NRAMP1 in human neutrophil granules Blood. 100: 268-275. PMID 12070036 DOI: 10.1182/Blood.V100.1.268  0.36
2002 Cai J, Daoud R, Alqawi O, Georges E, Pelletier J, Gros P. Nucleotide binding and nucleotide hydrolysis properties of the ABC transporter MRP6 (ABCC6). Biochemistry. 41: 8058-67. PMID 12069597 DOI: 10.1021/Bi012082P  0.325
2002 Fortin A, Stevenson MM, Gros P. Complex genetic control of susceptibility to malaria in mice. Genes and Immunity. 3: 177-86. PMID 12058252 DOI: 10.1038/Sj.Gene.6363841  0.802
2002 Sebastiani G, Blais V, Sancho V, Vogel SN, Stevenson MM, Gros P, Lapointe JM, Rivest S, Malo D. Host immune response to Salmonella enterica serovar Typhimurium infection in mice derived from wild strains. Infection and Immunity. 70: 1997-2009. PMID 11895964 DOI: 10.1128/IAI.70.4.1997-2009.2002  0.557
2001 Fortin A, Cardon LR, Tam M, Skamene E, Stevenson MM, Gros P. Identification of a new malaria susceptibility locus (Char4) in recombinant congenic strains of mice. Proceedings of the National Academy of Sciences of the United States of America. 98: 10793-8. PMID 11535821 DOI: 10.1073/Pnas.191288998  0.813
2001 Cai J, Daoud R, Georges E, Gros P. Functional expression of multidrug resistance protein 1 in Pichia pastoris. Biochemistry. 40: 8307-16. PMID 11444977 DOI: 10.1021/Bi010093C  0.374
2001 Kibar Z, Vogan KJ, Groulx N, Justice MJ, Underhill DA, Gros P. Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail. Nature Genetics. 28: 251-5. PMID 11431695 DOI: 10.1038/90081  0.346
2001 Kibar Z, Underhill DA, Canonne-Hergaux F, Gauthier S, Justice MJ, Gros P. Identification of a new chemically induced allele (Lp(m1Jus)) at the loop-tail locus: morphology, histology, and genetic mapping. Genomics. 72: 331-7. PMID 11401449 DOI: 10.1006/Geno.2000.6493  0.317
2001 Fortin A, Diez E, Rochefort D, Laroche L, Malo D, Rouleau GA, Gros P, Skamene E. Recombinant congenic strains derived from A/J and C57BL/6J: a tool for genetic dissection of complex traits. Genomics. 74: 21-35. PMID 11374899 DOI: 10.1006/Geno.2001.6528  0.571
2001 Lee SH, Girard S, Macina D, Busà M, Zafer A, Belouchi A, Gros P, Vidal SM. Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamily. Nature Genetics. 28: 42-5. PMID 11326273 DOI: 10.1038/ng0501-42  0.334
2001 Canonne-Hergaux F, Levy JE, Fleming MD, Montross LK, Andrews NC, Gros P. Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders. Blood. 97: 1138-40. PMID 11159549 DOI: 10.1182/Blood.V97.4.1138  0.301
2001 Daoud R, Julien M, Gros P, Georges E. Major photoaffinity drug binding sites in multidrug resistance protein 1 (MRP1) are within transmembrane domains 10-11 and 16-17. The Journal of Biological Chemistry. 276: 12324-30. PMID 11152467 DOI: 10.1074/Jbc.M009782200  0.318
2000 Mitsos LM, Cardon LR, Fortin A, Ryan L, LaCourse R, North RJ, Gros P. Genetic control of susceptibility to infection with Mycobacterium tuberculosis in mice. Genes and Immunity. 1: 467-77. PMID 11197687 DOI: 10.1038/sj.gene.6363712  0.813
2000 Daoud R, Kast C, Gros P, Georges E. Rhodamine 123 binds to multiple sites in the multidrug resistance protein (MRP1). Biochemistry. 39: 15344-52. PMID 11112520 DOI: 10.1021/Bi0020574  0.346
2000 Urbatsch IL, Julien M, Carrier I, Rousseau ME, Cayrol R, Gros P. Mutational analysis of conserved carboxylate residues in the nucleotide binding sites of P-glycoprotein Biochemistry. 39: 14138-14149. PMID 11087362 DOI: 10.1021/Bi001128W  0.322
2000 Jabado N, Jankowski A, Dougaparsad S, Picard V, Grinstein S, Gros P. Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane. The Journal of Experimental Medicine. 192: 1237-48. PMID 11067873 DOI: 10.1084/Jem.192.9.1237  0.409
2000 Matte C, Marquis JF, Blanchette J, Gros P, Faure R, Posner BI, Olivier M. Peroxovanadium-mediated protection against murine leishmaniasis: role of the modulation of nitric oxide. European Journal of Immunology. 30: 2555-64. PMID 11009089 DOI: 10.1002/1521-4141(200009)30:9<2555::Aid-Immu2555>3.0.Co;2-X  0.339
2000 Fortin A, Penman M, Stevenson MM, Krieger M, Gros P. Identification and characterization of naturally occurring variants of the macrophage scavenger receptor (SR-A). Mammalian Genome : Official Journal of the International Mammalian Genome Society. 11: 779-85. PMID 10967138 DOI: 10.1007/S003350010131  0.572
2000 Picard V, Govoni G, Jabado N, Gros P. Nramp 2 (DCT1/DMT1) expressed at the plasma membrane transports iron and other divalent cations into a calcein-accessible cytoplasmic pool. Journal of Biological Chemistry. 275: 35738-35745. PMID 10942769 DOI: 10.1074/Jbc.M005387200  0.738
2000 Underhill DA, Vogan KJ, Kibar Z, Morrison J, Rommens J, Gros P. Transcription mapping and expression analysis of candidate genes in the vicinity of the mouse Loop-tail mutation. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 11: 633-8. PMID 10920231 DOI: 10.1007/S003350010118  0.404
2000 Kwan T, Loughrey H, Brault M, Gruenheid S, Urbatsch IL, Senior AE, Gros P. Functional analysis of a tryptophan-less P-glycoprotein: a tool for tryptophan insertion and fluorescence spectroscopy. Molecular Pharmacology. 58: 37-47. PMID 10860925 DOI: 10.1124/Mol.58.1.37  0.719
2000 Depatie C, Lee SH, Stafford A, Avner P, Belouchi A, Gros P, Vidal SM. Sequence-ready BAC contig, physical, and transcriptional map of a 2-Mb region overlapping the mouse chromosome 6 host-resistance locus Cmv1. Genomics. 66: 161-74. PMID 10860661 DOI: 10.1006/Geno.2000.6186  0.792
2000 Daoud R, Desneves J, Deady LW, Tilley L, Scheper RJ, Gros P, Georges E. The multidrug resistance protein is photoaffinity labeled by a quinoline-based drug at multiple sites. Biochemistry. 39: 6094-102. PMID 10821682 DOI: 10.1021/Bi9922188  0.335
2000 Julien M, Gros P. Nucleotide-induced conformational changes in P-glycoprotein and in nucleotide binding site mutants monitored by trypsin sensitivity Biochemistry. 39: 4559-4568. PMID 10758006 DOI: 10.1021/Bi992744Z  0.341
2000 Sebastiani G, Leveque G, Larivière L, Laroche L, Skamene E, Gros P, Malo D. Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice. Genomics. 64: 230-40. PMID 10756091 DOI: 10.1006/Geno.2000.6115  0.611
2000 Gruenheid S, Gros P. Genetic susceptibility to intracellular infections: Nramp1, macrophage function and divalent cations transport. Current Opinion in Microbiology. 3: 43-8. PMID 10679418 DOI: 10.1016/S1369-5274(99)00049-1  0.682
2000 Diez E, Yaraghi Z, MacKenzie A, Gros P. The neuronal apoptosis inhibitory protein (Naip) is expressed in macrophages and is modulated after phagocytosis and during intracellular infection with Legionella pneumophila. Journal of Immunology (Baltimore, Md. : 1950). 164: 1470-7. PMID 10640764 DOI: 10.4049/Jimmunol.164.3.1470  0.416
2000 Julien M, Kajiji S, Kaback RH, Gros P. Simple purification of highly active biotinylated P-glycoprotein: enantiomer-specific modulation of drug-stimulated ATPase activity. Biochemistry. 39: 75-85. PMID 10625481 DOI: 10.1021/Bi991726E  0.313
2000 Canonne-Hergaux F, Fleming MD, Levy JE, Gauthier S, Ralph T, Picard V, Andrews NC, Gros P. The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border. Blood. 96: 3964-3970. DOI: 10.1182/Blood.V96.12.3964.H8003964_3964_3970  0.344
2000 Picard V, Canonne-Hergauxn F, Cellier M, Gros P. Nramp proteins, susceptibility to infection and divalent cations transport Genetics in Medicine. 2: 50-50. DOI: 10.1097/00125817-200001000-00025  0.343
1999 North RJ, LaCourse R, Ryan L, Gros P. Consequence of Nramp1 Deletion to Mycobacterium tuberculosis Infection in Mice Infection and Immunity. 67: 5811-5814. PMID 10531233 DOI: 10.1128/Iai.67.11.5811-5814.1999  0.404
1999 Qureshi ST, Gros P, Malo D. Host resistance to infection genetic control of lipopolysaccharide responsiveness by TOLL-like receptor genes Trends in Genetics. 15: 291-294. PMID 10431187 DOI: 10.1016/S0168-9525(99)01782-5  0.398
1999 Canonne-Hergaux F, Gruenheid S, Govoni G, Gros P. The Nramp1 protein and its role in resistance to infection and macrophage function. Proceedings of the Association of American Physicians. 111: 283-9. PMID 10417735 DOI: 10.1046/j.1525-1381.1999.99236.x  0.825
1999 Yaraghi Z, Diez E, Gros P, MacKenzie A. cDNA cloning and the 5'genomic organization of Naip2, a candidate gene for murine Legionella resistance. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 10: 761-3. PMID 10384056 DOI: 10.1007/S003359901087  0.327
1999 Canonne-Hergaux F, Gruenheid S, Ponka P, Gros P. Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood. 93: 4406-17. PMID 10361139 DOI: 10.1182/Blood.V93.12.4406.412K21_4406_4417  0.605
1999 Govoni G, Canonne-Hergaux F, Pfeifer CG, Marcus SL, Mills SD, Hackam DJ, Grinstein S, Malo D, Finlay BB, Gros P. Functional expression of Nramp1 in vitro in the murine macrophage line RAW264.7. Infection and Immunity. 67: 2225-32. PMID 10225878 DOI: 10.1128/Iai.67.5.2225-2232.1999  0.776
1999 Ruetz S, Brault M, Dalton W, Gros P. Functional interactions between synthetic alkyl phospholipids and the ABC transporters P-glycoprotein, ste-6, MRP, and pgh-1 Biochemistry. 38: 2860. PMID 10052958 DOI: 10.1021/Bi995067H  0.324
1999 Gruenheid S, Canonne-Hergaux F, Gauthier S, Hackam DJ, Grinstein S, Gros P. The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes. The Journal of Experimental Medicine. 189: 831-41. PMID 10049947 DOI: 10.1084/Jem.189.5.831  0.675
1999 Underhill DA, Mullick A, Groulx N, Beatty BG, Gros P. Physical delineation of a 700-kb region overlapping the Looptail mutation on mouse chromosome 1. Genomics. 55: 185-93. PMID 9933565 DOI: 10.1006/Geno.1998.5643  0.364
1999 Bussmann V, Lantier I, Pitel F, Patri S, Nau F, Gros P, Elsen JM, Lantier F. cDNA cloning, structural organization, and expression of the sheep NRAMP1 gene. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 9: 1027-31. PMID 9880672 DOI: 10.1007/S003359900919  0.383
1999 Gruenheid S, Skamene E, Gros P. Nramp1. A novel macrophage protein with a key function in resistance to intracellular pathogens Advances in Cellular and Molecular Biology of Membranes and Organelles. 5: 345-362. DOI: 10.1016/S1874-5172(99)80039-X  0.708
1998 Fortin AS, Underhill DA, Gros P. Helix 2 of the paired domain plays a key role in the regulation of DNA-binding by the Pax-3 homeodomain. Nucleic Acids Research. 26: 4574-81. PMID 9753723 DOI: 10.1093/Nar/26.20.4574  0.764
1998 Reece M, Prawitt D, Landers J, Kast C, Gros P, Housman D, Zabel BU, Pelletier J. Functional characterization of ORCTL2--an organic cation transporter expressed in the renal proximal tubules. Febs Letters. 433: 245-50. PMID 9744804 DOI: 10.1016/S0014-5793(98)00907-7  0.374
1998 Govoni G, Gros P. Macrophage NRAMP1 and its role in resistance to microbial infections Inflammation Research. 47: 277-284. PMID 9719491 DOI: 10.1007/S000110050330  0.8
1998 Beaudet L, Gros P. Mutational analysis of P-glycoprotein in yeast Saccharomyces cerevisiae Methods in Enzymology. 292: 414-427. PMID 9711571 DOI: 10.1016/S0076-6879(98)92032-8  0.409
1998 Beaudet L, Urbatsch IL, Gros P. High-level expression of mouse Mdr3 P-glycoprotein in yeast Pichia pastoris and characterization of ATPase activity Methods in Enzymology. 292: 397-413. PMID 9711570 DOI: 10.1016/S0076-6879(98)92031-6  0.365
1998 Hackam DJ, Rotstein OD, Zhang W, Gruenheid S, Gros P, Grinstein S. Host resistance to intracellular infection: mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification. The Journal of Experimental Medicine. 188: 351-64. PMID 9670047 DOI: 10.1084/Jem.188.2.351  0.7
1998 Beaudet L, Urbatsch IL, Gros P. Mutations in the nucleotide-binding sites of P-Glycporotein that affect substrate specificity modulate substrate-induced adenosine Triphosphatase activity Biochemistry. 37: 9073-9082. PMID 9636053 DOI: 10.1021/Bi972656J  0.351
1998 Urbatsch IL, Beaudet L, Carrier I, Gros P. Mutations in either nucleotide-binding site of P-glycoprotein (Mdr3) prevent vanadate trapping of nucleotide at both sites Biochemistry. 37: 4592-4602. PMID 9521779 DOI: 10.1021/Bi9728001  0.334
1998 Kwan T, Gros P. Mutational analysis of the P-glycoprotein first intracellular loop and flanking transmembrane domains. Biochemistry. 37: 3337-50. PMID 9521654 DOI: 10.1021/Bi972680X  0.537
1998 Skamene E, Schurr E, Gros P. Infection genomics: Nramp1 as a major determinant of natural resistance to intracellular infections. Annual Review of Medicine. 49: 275-87. PMID 9509263 DOI: 10.1146/Annurev.Med.49.1.275  0.371
1998 Kast C, Gros P. Epitope insertion favors a six transmembrane domain model for the carboxy-terminal portion of the multidrug resistance-associated protein Biochemistry. 37: 2305-2313. PMID 9485377 DOI: 10.1021/Bi972332V  0.369
1998 Sebastiani G, Olien L, Gauthier S, Skamene E, Morgan K, Gros P, Malo D. Mapping of genetic modulators of natural resistance to infection with Salmonella typhimurium in wild-derived mice. Genomics. 47: 180-6. PMID 9479490 DOI: 10.1006/Geno.1997.5116  0.656
1997 Fortin A, Belouchi A, Tam MF, Cardon L, Skamene E, Stevenson MM, Gros P. Genetic control of blood parasitaemia in mouse malaria maps to chromosome 8. Nature Genetics. 17: 382-3. PMID 9398835 DOI: 10.1038/Ng1297-382  0.528
1997 Pinner E, Gruenheid S, Raymond M, Gros P. Functional complementation of the yeast divalent cation transporter family SMF by NRAMP2, a member of the mammalian natural resistance-associated macrophage protein family. The Journal of Biological Chemistry. 272: 28933-8. PMID 9360964 DOI: 10.1074/Jbc.272.46.28933  0.687
1997 Kast C, Gros P. Topology mapping of the amino-terminal half of multidrug resistance-associated protein by epitope insertion and immunofluorescence. The Journal of Biological Chemistry. 272: 26479-87. PMID 9334225 DOI: 10.1074/Jbc.272.42.26479  0.379
1997 Fortin AS, Underhill DA, Gros P. Reciprocal effect of Waardenburg syndrome mutations on DNA binding by the Pax-3 paired domain and homeodomain. Human Molecular Genetics. 6: 1781-90. PMID 9302254 DOI: 10.1093/Hmg/6.11.1781  0.765
1997 Diez E, Beckers MC, Ernst E, DiDonato CJ, Simard LR, Morissette C, Gervais F, Yoshida SI, Gros P. Genetic and physical mapping of the mouse host resistance locus Lgn1. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 8: 682-5. PMID 9271671 DOI: 10.1007/S003359900536  0.368
1997 Govoni G, Gauthier S, Billia F, Iscove NN, Gros P. Cell-specific and inducible Nramp1 gene expression in mouse macrophages in vitro and in vivo. Journal of Leukocyte Biology. 62: 277-286. PMID 9261342 DOI: 10.1002/Jlb.62.2.277  0.754
1997 Belouchi A, Kwan T, Gros P. Cloning and characterization of the OsNramp family from Oryza sativa, a new family of membrane proteins possibly implicated in the transport of metal ions. Plant Molecular Biology. 33: 1085-92. PMID 9154989 DOI: 10.1023/A:1005723304911  0.523
1997 Beckers MC, Ernst E, Diez E, Morissette C, Gervais F, Hunter K, Housman D, Yoshida S, Skamene E, Gros P. High-resolution linkage map of mouse chromosome 13 in the vicinity of the host resistance locus Lgn1. Genomics. 39: 254-63. PMID 9119362 DOI: 10.1006/Geno.1996.4489  0.428
1997 Gruenheid S, Pinner E, Desjardins M, Gros P. Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome. The Journal of Experimental Medicine. 185: 717-30. PMID 9034150 DOI: 10.1084/Jem.185.4.717  0.686
1997 Depatie C, Muise E, Lepage P, Gros P, Vidal SM. High-resolution linkage map in the proximity of the host resistance locus Cmv1. Genomics. 39: 154-63. PMID 9027502 DOI: 10.1006/Geno.1996.4498  0.793
1997 Cellier M, Shustik C, Dalton W, Rich E, Hu J, Malo D, Schurr E, Gros P. Expression of the human NRAMP1 gene in professional primary phagocytes: studies in blood cells and in HL-60 promyelocytic leukemia. Journal of Leukocyte Biology. 61: 96-105. PMID 9000542 DOI: 10.1002/Jlb.61.1.96  0.386
1997 Bussmann V, Lantier I, Pitel F, Patri S, Nau F, Gros P, Elsen J, Lantier F. Genomic organization of the sheep natural resistance associated macrophage protein (NRAMP1) gene Immunology Letters. 56: 121. DOI: 10.1016/S0165-2478(97)85484-3  0.351
1997 Cellier M, Gros P. The NRAMP1 gene: Resistance to intracellular infections and antimicrobial activity of phagocytes Medecine/Sciences. 13: 501-508.  0.351
1996 Vogan KJ, Underhill DA, Gros P. An alternative splicing event in the Pax-3 paired domain identifies the linker region as a key determinant of paired domain DNA-binding activity Molecular and Cellular Biology. 16: 6677-6686. PMID 8943322 DOI: 10.1128/Mcb.16.12.6677  0.31
1996 Cellier K, Belouchi A, Gros P. Resistance to intracellular infections: Comparative genomic analysis of Nramp Trends in Genetics. 12: 201-204. PMID 8928221 DOI: 10.1016/0168-9525(96)30042-5  0.343
1996 Qureshi ST, Larivière L, Sebastiani G, Clermont S, Skamene E, Gros P, Malo D. A high-resolution map in the chromosomal region surrounding the Lps locus. Genomics. 31: 283-94. PMID 8838309 DOI: 10.1006/Geno.1996.0050  0.575
1996 Beckers MC, Ernst E, Belcher S, Howe J, Levenson R, Gros P. A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2. Genomics. 36: 202-5. PMID 8812438 DOI: 10.1006/Geno.1996.0447  0.323
1996 Ruetz S, Delling U, Brault M, Schurr E, Gros P. The pfmdr1 gene of Plasmodium falciparum confers cellular resistance to antimalarial drugs in yeast cells Proceedings of the National Academy of Sciences of the United States of America. 93: 9942-9947. PMID 8790436 DOI: 10.1073/Pnas.93.18.9942  0.388
1996 Jones JM, Ranscht B, Berglund EO, Gruenheid S, Gros P, Meisler MH. Close linkage of three neuronal genes on distal mouse chromosome 15. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 7: 696-7. PMID 8703126 DOI: 10.1007/S003359900209  0.619
1996 Goodfellow HR, Sardini A, Ruetz S, Callaghan R, Gros P, McNaughton PA, Higgins CF. Protein kinase C-mediated phosphorylation does not regulate drug transport by the human multidrug resistance P-glycoprotein. The Journal of Biological Chemistry. 271: 13668-74. PMID 8662768 DOI: 10.1074/Jbc.271.23.13668  0.333
1996 Hanna M, Brault M, Kwan T, Kast C, Gros P. Mutagenesis of transmembrane domain 11 of P-glycoprotein by alanine scanning. Biochemistry. 35: 3625-35. PMID 8639515 DOI: 10.1021/Bi951333P  0.525
1996 Hu J, Bumstead N, Skamene E, Gros P, Malo D. Structural organization, sequence, and expression of the chicken NRAMP1 gene encoding the natural resistance-associated macrophage protein 1 Dna and Cell Biology. 15: 113-123. PMID 8634139 DOI: 10.1089/Dna.1996.15.113  0.452
1996 Ruetz S, Brault M, Kast C, Hemenway C, Heitman J, Grant CE, Cole SP, Deeley RG, Gros P. Functional expression of the multidrug resistance-associated protein in the yeast Saccharomyces cerevisiae. The Journal of Biological Chemistry. 271: 4154-60. PMID 8626756 DOI: 10.1074/Jbc.271.8.4154  0.393
1996 Kast C, Canfield V, Levenson R, Gros P. Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence. The Journal of Biological Chemistry. 271: 9240-8. PMID 8621583 DOI: 10.1074/Jbc.271.16.9240  0.328
1996 Beckers MC, Yoshida S, Morgan K, Skamene E, Gros P. Natural resistance to infection with Legionella pneumophila: chromosomal localization of the Lgn1 susceptibility gene. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 6: 540-5. PMID 8589525 DOI: 10.1007/Bf00356173  0.424
1996 Govoni G, Vidal S, Gauthier S, Skamene E, Malo D, Gros P. The Bcg/Ity/Lsh locus: genetic transfer of resistance to infections in C57BL/6J mice transgenic for the Nramp1 Gly169 allele. Infection and Immunity. 64: 2923-2929. DOI: 10.1128/iai.64.8.2923-2929.1996  0.756
1995 Belouchi A, Cellier M, Kwan T, Saini HS, Leroux G, Gros P. The macrophage-specific membrane protein Nramp controlling natural resistance to infections in mice has homologues expressed in the root system of plants. Plant Molecular Biology. 29: 1181-96. PMID 8616217 DOI: 10.1007/Bf00020461  0.579
1995 Hu J, Bumstead N, Burke D, Ponce de León FA, Skamene E, Gros P, Malo D. Genetic and physical mapping of the natural resistance-associated macrophage protein 1 (NRAMP1) in chicken Mammalian Genome. 6: 809-815. PMID 8597640 DOI: 10.1007/Bf00539010  0.377
1995 Mullick A, Groulx N, Trasler D, Gros P. Nhlh1, a basic helix-loop-helix transcription factor, is very tightly linked to the mouse looptail (Lp) mutation. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 6: 700-4. PMID 8563167 DOI: 10.1007/Bf00354291  0.32
1995 Gruenheid S, Cellier M, Vidal S, Gros P. Identification and characterization of a second mouse Nramp gene. Genomics. 25: 514-25. PMID 7789986 DOI: 10.1016/0888-7543(95)80053-O  0.692
1995 Qureshi ST, Gros P, Letarte M, Malo D. The murine endoglin gene (Eng) maps to chromosome 2 Genomics. 26: 165-166. PMID 7782079 DOI: 10.1016/0888-7543(95)80099-8  0.308
1995 Sebastiani G, Durocher D, Gros P, Nemer M, Malo D. Localization of the Catf1 transcription factor gene to mouse chromosome 19. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 6: 147-8. PMID 7767002 DOI: 10.1007/Bf00303264  0.559
1995 Govoni G, Vidal S, Cellier M, Lepage P, Malo D, Gros P. Genomic Structure, Promoter Sequence, and Induction of Expression of the Mouse Nramp1 Gene in Macrophages Genomics. 27: 9-19. PMID 7665187 DOI: 10.1006/Geno.1995.1002  0.771
1995 Vidal S, Tremblay ML, Govoni G, Gauthier S, Sebastiani G, Malo D, Skamene E, Olivier M, Jothy S, Gros P. The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene. The Journal of Experimental Medicine. 182: 655-66. PMID 7650477 DOI: 10.1084/Jem.182.3.655  0.827
1995 Beaudet L, Gros P. Functional dissection of p-glycoprotein nucleotide-binding domains in chimeric and mutant proteins: Modulation of drug resistance profiles Journal of Biological Chemistry. 270: 17159-17170. PMID 7615512 DOI: 10.1074/Jbc.270.29.17159  0.354
1995 Vidal S, Belouchi AM, Cellier M, Beatty B, Gros P. Cloning and characterization of a second human NRAMP gene on chromosome 12q13. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 6: 224-30. PMID 7613023 DOI: 10.1007/Bf00352405  0.397
1995 Mullick A, Trasler D, Gros P. High-resolution linkage map in the vicinity of the Lp locus Genomics. 26: 479-488. PMID 7607671 DOI: 10.1016/0888-7543(95)80166-J  0.333
1995 Ruetz S, Gros P. Enhancement of Mdr2-mediated phosphatidylcholine translocation by the bile salt taurocholate: Implications for hepatic bile formation Journal of Biological Chemistry. 270: 25388-25395. PMID 7592705 DOI: 10.1074/Jbc.270.43.25388  0.316
1995 Vidal S, Gros P, Skamene E. Natural resistance to infection with intracellular parasites: Molecular genetics identifies Nramp1 as the Bcg/Ity/Lsh locus Journal of Leukocyte Biology. 58: 382-390. PMID 7561513 DOI: 10.1002/Jlb.58.4.382  0.503
1995 Kast C, Canfield V, Levenson R, Gros P. Membrane topology of P-glycoprotein as determined by epitope insertion: transmembrane organization of the N-terminal domain of mdr3. Biochemistry. 34: 4402-11. PMID 7535563 DOI: 10.1021/Bi00013A032  0.338
1995 Cellier M, Privé G, Belouchi A, Kwan T, Rodrigues V, Chia W, Gros P. Nramp defines a family of membrane proteins Proceedings of the National Academy of Sciences of the United States of America. 92: 10089-10093. PMID 7479731 DOI: 10.1073/Pnas.92.22.10089  0.509
1995 Gros P. Human (MDR1) and mouse (mdr1,mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators Biochemistry®. 34: 32-39. DOI: 10.1021/Bi00001A005  0.328
1994 Epstein DJ, Bardeesy N, Vidal S, Malo D, Weith A, Vekemans M, Gros P. Characterization of a Region-Specific Library of Microclones in the Vicinity of the Bcg and splotch Loci on Mouse Chromosome 1 Genomics. 19: 163-166. PMID 8188220 DOI: 10.1006/Geno.1994.1029  0.394
1994 Kajiji S, Dreslin JA, Grizzuti K, Gros P. Structurally distinct MDR modulators show specific patterns of reversal against P-glycoproteins bearing unique mutations at serine939/941. Biochemistry. 33: 5041-8. PMID 8172879 DOI: 10.1021/Bi00183A006  0.316
1994 Cellier M, Govoni G, Vidal S, Kwan T, Groulx N, Liu J, Sanchez F, Skamene E, Schurr E, Gros P. Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression. The Journal of Experimental Medicine. 180: 1741-52. PMID 7964458 DOI: 10.1084/Jem.180.5.1741  0.81
1994 Ruetz S, Gros P. A mechanism for P-glycoprotein action in multidrug resistance: are we there yet? Trends in Pharmacological Sciences. 15: 260-263. PMID 7940990 DOI: 10.1016/0165-6147(94)90322-0  0.343
1994 Ruetz S, Gros P. Phosphatidylcholine translocase: A physiological role for the mdr2 gene Cell. 77: 1071-1081. PMID 7912658 DOI: 10.1016/0092-8674(94)90446-4  0.34
1994 Malo D, Vogan K, Vidal S, Hu J, Cellier M, Schurr E, Fuks A, Bumstead N, Morgan K, Gros P. Haplotype Mapping and Sequence Analysis of the Mouse Nramp Gene Predict Susceptibility to Infection with Intracellular Parasites Genomics. 23: 51-61. PMID 7829102 DOI: 10.1006/Geno.1994.1458  0.419
1994 Buschman E, Lepage P, Gros P. P-glycoprotein homologues Cancer Treatment and Research. 73: 17-39. PMID 7536017 DOI: 10.1007/978-1-4615-2632-2_2  0.364
1994 Es HHGV, Karcz S, Chu F, Cowman AF, Vidal S, Gros P, Schurr E. Expression of the plasmodial pfmdr1 gene in mammalian cells is associated with increased susceptibility to chloroquine. Molecular and Cellular Biology. 14: 2419-2428. PMID 7511206 DOI: 10.1128/Mcb.14.4.2419  0.417
1994 Vidal S, Gros P. Resistance to Infection With Intracellular Parasites. Identification of a Candidate Gene Physiology. 9: 178-183. DOI: 10.1152/Physiologyonline.1994.9.4.178  0.445
1993 Vidal SM, Malo D, Vogan K, Skamene E, Gros P. Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg Cell. 73: 469-485. PMID 8490962 DOI: 10.1016/0092-8674(93)90135-D  0.374
1993 Epstein DJ, Vogan KJ, Trasler DG, Gros P. A mutation within intron 3 of the Pax-3 gene produces aberrantly spliced mRNA transcripts in the splotch (Sp) mouse mutant Proceedings of the National Academy of Sciences of the United States of America. 90: 532-536. PMID 8421686 DOI: 10.1073/Pnas.90.2.532  0.317
1993 Vogan KJ, Epstein DJ, Trasler DG, Gros P. The Splotch-Delayed (Spd) Mouse Mutant Carries a Point Mutation within the Paired Box of the Pax-3 Gene Genomics. 17: 364-369. PMID 8406487 DOI: 10.1006/Geno.1993.1333  0.37
1993 Lepage P, Devault A, Gros P. Activation of the mouse mdr3 gene by insertion of retroviruses in multidrug-resistant P388 tumor cells Molecular and Cellular Biology. 13: 7380-7392. PMID 8246958 DOI: 10.1128/Mcb.13.12.7380  0.365
1993 Malo D, Vidal S, Lieman JH, Ward DC, Gros P. Physical Delineation of the Minimal Chromosomal Segment Encompassing the Murine Host Resistance Locus Bcg Genomics. 17: 667-675. PMID 8244383 DOI: 10.1006/Geno.1993.1388  0.376
1993 Bibi E, Gros P, Kaback HR. Functional expression of mouse mdr1 in Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 90: 9209-9213. PMID 8105473 DOI: 10.1073/Pnas.90.19.9209  0.383
1993 Dhir R, Grizzuti K, Kajiji S, Gros P. Modulatory effects on substrate specificity of independent mutations at the serine939/941 position in predicted transmembrane domain 11 of P-glycoproteins. Biochemistry. 32: 9492-9. PMID 8103679 DOI: 10.1021/Bi00087A030  0.366
1993 Malo D, Vidal SM, Hu J, Skamene E, Gros P. High-Resolution Linkage Map in the Vicinity of the Host Resistance Locus Bcg Genomics. 16: 655-663. PMID 8100801 DOI: 10.1006/Geno.1993.1244  0.398
1993 Malo D, Gros P, Bergmann A, Trask B, Mohrenweiser HW, Canfield VA, Levenson R. Genes encoding the H,K-ATPase alpha and Na,K-ATPase alpha 3 subunits are linked on mouse chromosome 7 and human chromosome 19. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 4: 644-9. PMID 7904196 DOI: 10.1007/Bf00360901  0.32
1993 Ruetz S, Raymond M, Gros P. Functional expression of P-glycoprotein encoded by the mouse mdr3 gene in yeast cells Proceedings of the National Academy of Sciences of the United States of America. 90: 11588-11592. PMID 7903452 DOI: 10.1073/Pnas.90.24.11588  0.321
1993 Kajiji S, Talbot F, Grizzuti K, Van Dyke-Phillips V, Agresti M, Safa AR, Gros P. Functional analysis of P-glycoprotein mutants identifies predicted transmembrane domain 11 as a putative drug binding site. Biochemistry. 32: 4185-94. PMID 7682843 DOI: 10.1021/Bi00067A005  0.312
1993 Lepage P, Gros P. Structural and functional aspects of P-glycoproteins and related transport proteins Current Opinion in Nephrology and Hypertension. 2: 735-743. PMID 7522912 DOI: 10.1097/00041552-199309000-00007  0.342
1992 Vidal SM, Epstein DJ, Malo D, Weith A, Vekemans M, Gros P. Identification and mapping of six microdissected genomic DNA probes to the proximal region of mouse chromosome 1 Genomics. 14: 32-37. PMID 1358796 DOI: 10.1016/S0888-7543(05)80279-4  0.301
1992 Dhir R, Gros P. Functional analysis of chimeric proteins constructed by exchanging homologous domains of two P-glycoproteins conferring distinct drug cesistance profiles Biochemistry. 31: 6103-6110. PMID 1352702 DOI: 10.1021/Bi00141A021  0.371
1992 Raymond M, Gros P, Whiteway M, Thomas DY. Functional complementation of yeast ste6 by a mammalian multidrug resistance mdr gene Science. 256: 232-234. PMID 1348873 DOI: 10.1126/Science.1348873  0.395
1991 Schurr E, Malo D, Radzioch D, Buschman E, Morgan K, Gros P, Skamene E. Genetic control of innate resistance to mycobacterial infections. Immunology Today. 12: A42-5. PMID 2069678 DOI: 10.1016/S0167-5699(05)80012-X  0.315
1991 Epstein DJ, Malo D, Vekemans M, Gros P. Molecular characterization of a deletion encompassing the splotch mutation on mouse chromosome 1 Genomics. 10: 89-93. PMID 2045114 DOI: 10.1016/0888-7543(91)90488-Z  0.36
1991 Buschman E, Gros P. Functional Analysis of Chimeric Genes Obtained by Exchanging Homologous Domains of the Mouse mdr1 and mdr2 Genes Molecular and Cellular Biology. 11: 595-603. PMID 1990275 DOI: 10.1128/Mcb.11.2.595  0.365
1991 Schurr E, Skamene E, Morgan K, Chu ML, Gros P. Mapping of Col3a1 and Col6a3 to proximal murine chromosome 1 identifies conserved linkage of structural protein genes between murine chromosome 1 and human chromosome 2q. Genomics. 8: 477-86. PMID 1981051 DOI: 10.1016/0888-7543(90)90034-R  0.339
1991 Shustik C, Groulx N, Gros P. Analysis of multidrug resistance (MDR-1) gene expression in chronic lymphocytic leukaemia (CLL). British Journal of Haematology. 79: 50-6. PMID 1911388 DOI: 10.1111/J.1365-2141.1991.Tb08006.X  0.34
1991 Schurr E, Morgan K, Gros P, Skamene E. Genetics of leprosy. The American Journal of Tropical Medicine and Hygiene. 44: 4-11. PMID 1904201 DOI: 10.4269/Ajtmh.1991.44.4  0.318
1991 Epstein DJ, Vekemans M, Gros P. splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3 Cell. 67: 767-774. PMID 1682057 DOI: 10.1016/0092-8674(91)90071-6  0.378
1991 Gros P, Shustik C. Multidrug resistance: A novel class of membrane-associated transport proteins is identified Cancer Investigation. 9: 563-569. PMID 1682020 DOI: 10.3109/07357909109018954  0.336
1991 Gros P, Dhir R, Croop J, Talbot F. A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps. Proceedings of the National Academy of Sciences of the United States of America. 88: 7289-93. PMID 1678520 DOI: 10.1073/Pnas.88.16.7289  0.362
1991 Malo D, Schurr E, Epstein DJ, Vekemans M, Skamene E, Gros P. The host resistance locus Bcg is tightly linked to a group of cytoskeleton-associated protein genes that include villin and desmin Genomics. 10: 356-364. PMID 1676979 DOI: 10.1016/0888-7543(91)90320-E  0.432
1991 Schurr E, Malo D, Radzioch D, Buschman E, Morgan K, Gros P, Skamene E. Genetic control of innate resistance to mycobacterial infections Parasitology Today. 7: 42-45. DOI: 10.1016/0169-4758(91)90029-N  0.315
1990 Raymond M, Gros P. Cell-specific activity of as-acting regulatory elements in the promoter of the mouse multidrug resistance gene mdrl Molecular and Cellular Biology. 10: 6036-6040. PMID 2248681 DOI: 10.1128/Mcb.10.11.6036  0.339
1990 Schurr E, Buschman E, Malo D, Gros P, Skamene E. Immunogenetics of mycobacterial infections: Mouse-human homologies Journal of Infectious Diseases. 161: 634-639. PMID 2181030 DOI: 10.1093/infdis/161.4.634  0.328
1990 Mock B, Krall M, Blackwell J, O'Brien A, Schurr E, Gros P, Skamene E, Potter M. A genetic map of mouse chromosome 1 near the Lsh-Ity-Bcg disease resistance locus. Genomics. 7: 57-64. PMID 1970800 DOI: 10.1016/0888-7543(90)90518-Y  0.417
1990 Devault A, Gros P. Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities Molecular and Cellular Biology. 10: 1652-1663. PMID 1969610 DOI: 10.1128/Mcb.10.4.1652  0.395
1990 Raymond M, Rose E, Housman DE, Gros P. Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells. Molecular and Cellular Biology. 10: 1642-51. PMID 1969609 DOI: 10.1128/Mcb.10.4.1642  0.375
1989 Azzaria M, Schurr E, Gros P. Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance Molecular and Cellular Biology. 9: 5289-5297. PMID 2573836 DOI: 10.1128/Mcb.9.12.5289  0.374
1988 Guild BC, Mulligan RC, Gros P, Housman DE. Retroviral transfer of a murine cDNA for multidrug resistance confers pleiotropic drug resistance to cells without prior drug selection. Proceedings of the National Academy of Sciences of the United States of America. 85: 1595-9. PMID 3422751 DOI: 10.1073/Pnas.85.5.1595  0.365
1988 Gros P, Raymond M, Bell J, Housman D. Cloning and characterization of a second member of the mouse mdr gene family. Molecular and Cellular Biology. 8: 2770-8. PMID 3405218 DOI: 10.1128/Mcb.8.7.2770  0.378
1988 Schurr E, Skamene E, Nesbitt M, Hynes R, Gros P. Identification of a linkage group including the Bcg gene by restriction fragment length polymorphism analysis Current Topics in Microbiology and Immunology. 137: 310-315. PMID 2901325 DOI: 10.1007/978-3-642-50059-6_46  0.397
1986 Gros P, Fallows DA, Croop JM, Housman DE. Chromosome-mediated gene transfer of multidrug resistance. Molecular and Cellular Biology. 6: 3785-90. PMID 3796594 DOI: 10.1128/Mcb.6.11.3785  0.376
1986 Gros P, Croop J, Housman D. Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell. 47: 371-80. PMID 3768958 DOI: 10.1016/0092-8674(86)90594-5  0.373
1986 Roninson IB, Chin JE, Choi KG, Gros P, Housman DE, Fojo A, Shen DW, Gottesman MM, Pastan I. Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proceedings of the National Academy of Sciences of the United States of America. 83: 4538-42. PMID 3459187 DOI: 10.1073/Pnas.83.12.4538  0.346
1986 Gros P, Ben Neriah YB, Croop JM, Housman DE. Isolation and expression of a complementary DNA that confers multidrug resistance. Nature. 323: 728-31. PMID 3022150 DOI: 10.1038/323728A0  0.36
1984 Skamene E, Gros P, Forget A, Patel PJ, Nesbitt MN. Regulation of resistance to leprosy by chromosome 1 locus in the mouse Immunogenetics. 19: 117-124. PMID 6365754 DOI: 10.1007/BF00387854  0.311
1983 Gros P, Skamene E, Forget A. Cellular mechanisms of genetically controlled host resistance to Mycobacterium bovis (BCG) Journal of Immunology. 131: 1966-1972. PMID 6311901  0.31
1983 Potter M, O'Brien AD, Skamene E, Gros P, Forget A, Kongshavn PA, Wax JS. A BALB/c congenic strain of mice that carries a genetic locus (Ityr) controlling resistance to intracellular parasites. Infection and Immunity. 40: 1234-1235. DOI: 10.1128/Iai.40.3.1234-1235.1983  0.359
1981 Gros P, Skamene E, Forget A. Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice Journal of Immunology. 127: 2417-2421. PMID 6795274  0.322
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