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Xuankuo Xu, Ph.D. - Publications

Affiliations: 
2008 Department of Chemical Engineering University of Delaware, Newark, DE, United States 
Area:
Chemical Engineering
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34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Bhoyar S, Kumar V, Foster M, Xu X, Traylor SJ, Guo J, Lenhoff AM. Predictive mechanistic modeling of loading and elution in protein A chromatography. Journal of Chromatography. A. 1713: 464558. PMID 38096684 DOI: 10.1016/j.chroma.2023.464558  0.773
2023 Herman CE, Min L, Choe LH, Maurer RW, Xu X, Ghose S, Lee KH, Lenhoff AM. Behavior of host-cell-protein-rich aggregates in antibody capture and polishing chromatography. Journal of Chromatography. A. 1702: 464081. PMID 37244165 DOI: 10.1016/j.chroma.2023.464081  0.604
2023 Bhoyar S, Foster M, Oh YH, Xu X, Traylor SJ, Guo J, Ghose S, Lenhoff AM. Engineering protein A ligands to mitigate antibody loss during high-pH washes in protein A chromatography. Journal of Chromatography. A. 1696: 463962. PMID 37043977 DOI: 10.1016/j.chroma.2023.463962  0.779
2023 Herman CE, Min L, Choe LH, Maurer RW, Xu X, Ghose S, Lee KH, Lenhoff AM. Analytical characterization of host-cell-protein-rich aggregates in monoclonal antibody solutions. Biotechnology Progress. e3343. PMID 37020359 DOI: 10.1002/btpr.3343  0.605
2023 Chu LK, Borujeni EE, Xu X, Ghose S, Zydney AL. Comparison of host cell protein removal by depth filters with diatomaceous earth and synthetic silica filter aids using model proteins. Biotechnology and Bioengineering. PMID 36929487 DOI: 10.1002/bit.28386  0.328
2022 Guo J, Noyes S, Jin W, Curtis H, Xu X, Ghose S. Effect of solution condition on the binding behaviors of monoclonal antibody and fusion protein therapeutics in Protein A chromatography. Journal of Chromatography. A. 1686: 463652. PMID 36434831 DOI: 10.1016/j.chroma.2022.463652  0.417
2021 Herman CE, Xu X, Traylor SJ, Ghose S, Li ZJ, Lenhoff AM. Behavior of weakly adsorbing protein impurities in flow-through ion-exchange chromatography. Journal of Chromatography. A. 1664: 462788. PMID 34998025 DOI: 10.1016/j.chroma.2021.462788  0.777
2020 Huang C, Wang Y, Xu X, Mills J, Jin W, Ghose S, Li ZJ. Hydrophobic property of cation-exchange resins affects monoclonal antibody aggregation. Journal of Chromatography. A. 1631: 461573. PMID 33010710 DOI: 10.1016/J.Chroma.2020.461573  0.371
2020 Li Y, Lock LL, Mills J, Ou BS, Morrow M, Stern D, Wang H, Anderson CF, Xu X, Ghose S, Li ZJ, Cui H. Selective Capture and Recovery of Monoclonal Antibodies by Self-Assembling Supramolecular Polymers of High Affinity for Protein Binding. Nano Letters. PMID 32852220 DOI: 10.1021/Acs.Nanolett.0C01297  0.361
2020 Feidl F, Luna MF, Podobnik M, Vogg S, Angelo J, Potter K, Wiggin E, Xu X, Ghose S, Li ZJ, Morbidelli M, Butté A. Model based strategies towards protein A resin lifetime optimization and supervision. Journal of Chromatography. A. 1625: 461261. PMID 32709318 DOI: 10.1016/J.Chroma.2020.461261  0.404
2020 Xing Z, Jin W, Xu X, Song Y, Huang C, Borys MC, Ghose S, Li ZJ. A CFD Model for Predicting Protein Aggregation in Low-pH Virial Inactivation for mAb Production. Biotechnology and Bioengineering. PMID 32672835 DOI: 10.1002/Bit.27505  0.417
2020 Xu J, Xu X, Huang C, Angelo J, Oliveira CL, Xu M, Xu X, Temel D, Ding J, Ghose S, Borys MC, Li ZJ. Biomanufacturing evolution from conventional to intensified processes for productivity improvement: a case study. Mabs. 1770669. PMID 32425110 DOI: 10.1080/19420862.2020.1770669  0.316
2019 Wälchli R, Ressurreição M, Vogg S, Feidl F, Angelo J, Xu X, Ghose S, Jian Li Z, Le Saoût X, Souquet J, Broly H, Morbidelli M. Understanding MAb Aggregation During Low pH Viral Inactivation and Subsequent Neutralization. Biotechnology and Bioengineering. PMID 31784982 DOI: 10.1002/Bit.27237  0.419
2019 Jin W, Xing Z, Song Y, Huang C, Xu X, Ghose S, Li ZJ. Protein aggregation and mitigation strategy in low pH viral inactivation for monoclonal antibody purification. Mabs. PMID 31441367 DOI: 10.1080/19420862.2019.1658493  0.417
2019 Khanal O, Xu X, Singh N, Traylor SJ, Huang C, Ghose S, Li ZJ, Lenhoff AM. DNA RETENTION ON DEPTH FILTERS. Journal of Membrane Science. 570: 464-471. PMID 31223185 DOI: 10.1016/J.Memsci.2018.10.058  0.741
2019 Angelo J, Chollangi S, Müller-Späth T, Jusyte S, Xu X, Ghose S, Li Z. Virus Clearance Validation across Continuous Capture Chromatography. Biotechnology and Bioengineering. PMID 31062872 DOI: 10.1002/Bit.27012  0.351
2019 Li Y, Stern D, Lin Lock L, Mills J, Ou SH, Morrow M, Xu X, Ghose S, Jian Li Z, Cui H. Emerging Biomaterials for Downstream Manufacturing of Therapeutic Proteins. Acta Biomaterialia. PMID 30862553 DOI: 10.1016/J.Actbio.2019.03.015  0.408
2018 Baur D, Angelo J, Chollangi S, Müller-Späth T, Xu X, Ghose S, Li ZJ, Morbidelli M. Model assisted process characterization and validation for a continuous two-column protein A capture process. Biotechnology and Bioengineering. PMID 30298905 DOI: 10.1002/Bit.26849  0.335
2018 Baur D, Angelo JM, Chollangi S, Xu X, Müller-Späth T, Zhang N, Ghose S, Li ZJ, Morbidelli M. Model assisted comparison of Protein A resins and multi-column chromatography for capture processes. Journal of Biotechnology. PMID 30165118 DOI: 10.1016/J.Jbiotec.2018.08.014  0.403
2018 Greene DG, Traylor SJ, Guo J, Choe LH, Modla S, Xu X, Singh N, Lock LL, Ghose S, Li ZJ, Lee KH, Wagner NJ, Lenhoff AM. Mechanisms of precipitate formation during the purification of an Fc-fusion protein. Biotechnology and Bioengineering. PMID 29896879 DOI: 10.1002/Bit.26746  0.767
2018 Swartz AR, Xu X, Traylor SJ, Li ZJ, Chen W. High-efficiency affinity precipitation of multiple industrial mAbs and Fc-fusion proteins from cell culture harvests using Z-ELP-E2 nanocages. Biotechnology and Bioengineering. PMID 29679468 DOI: 10.1002/Bit.26717  0.786
2018 Khanal O, Singh N, Traylor SJ, Xu X, Ghose S, Li ZJ, Lenhoff AM. Contributions of Depth Filter Components to Protein Adsorption in Protein Bioprocessing. Biotechnology and Bioengineering. PMID 29663326 DOI: 10.1002/Bit.26707  0.77
2018 Khanal O, Singh N, Traylor SJ, Xu X, Ghose S, Li ZJ, Lenhoff AM. Contributions of Depth Filter Components to Protein Adsorption in Protein Bioprocessing. Biotechnology and Bioengineering. PMID 29644625 DOI: 10.1002/bit.26607  0.774
2018 Xu J, Rehmann MS, Xu X, Huang C, Tian J, Qian NX, Li ZJ. Improving titer while maintaining quality of final formulated drug substance via optimization of CHO cell culture conditions in low-iron chemically defined media. Mabs. 0. PMID 29388872 DOI: 10.1080/19420862.2018.1433978  0.322
2017 Swartz A, Xu X, Traylor S, Li ZJ, Chen W. One-step affinity capture and precipitation for improved purification of an industrial monoclonal antibody using Z-ELP functionalized nanocages. Biotechnology and Bioengineering. PMID 28986999 DOI: 10.1002/Bit.26467  0.771
2016 Chen Z, Huang C, Chennamsetty N, Xu X, Li ZJ. Insights in understanding aggregate formation and dissociation in cation exchange chromatography for a structurally unstable Fc-fusion protein. Journal of Chromatography. A. PMID 27452990 DOI: 10.1016/J.Chroma.2016.07.023  0.479
2015 Li Y, Xu X, Shupe A, Yang R, Bai K, Das T, Borys MC, Li ZJ. Heterogeneous glycoform separation by process chromatography: I: Monomer purification and characterization. Journal of Chromatography. A. 1404: 51-9. PMID 26051082 DOI: 10.1016/J.Chroma.2015.05.054  0.404
2014 Traylor SJ, Xu X, Li Y, Jin M, Li ZJ. Adaptation of the pore diffusion model to describe multi-addition batch uptake high-throughput screening experiments. Journal of Chromatography. A. 1368: 100-6. PMID 25311484 DOI: 10.1016/J.Chroma.2014.09.058  0.78
2014 Xu X, Hirpara J, Epting K, Jin M, Ghose S, Rieble S, Li ZJ. Clarification and capture of high-concentration refold pools for E. coli-based therapeutics using expanded bed adsorption chromatography. Biotechnology Progress. 30: 113-23. PMID 24167114 DOI: 10.1002/Btpr.1833  0.463
2011 Traylor SJ, Xu X, Lenhoff AM. Shrinking-core modeling of binary chromatographic breakthrough. Journal of Chromatography. A. 1218: 2222-31. PMID 21411102 DOI: 10.1016/J.Chroma.2011.02.020  0.754
2010 Xu X, Didio DM, Leister KJ, Ghose S. Disaggregation of high-molecular weight species during downstream processing to recover functional monomer. Biotechnology Progress. 26: 717-26. PMID 20039266 DOI: 10.1002/Btpr.373  0.454
2009 Xu X, Lenhoff AM. Binary adsorption of globular proteins on ion-exchange media. Journal of Chromatography. A. 1216: 6177-95. PMID 19631326 DOI: 10.1016/J.Chroma.2009.06.082  0.612
2008 Xu X, Lenhoff AM. A predictive approach to correlating protein adsorption isotherms on ion-exchange media. The Journal of Physical Chemistry. B. 112: 1028-40. PMID 18171041 DOI: 10.1021/Jp0754233  0.661
2007 Langford JF, Xu X, Yao Y, Maloney SF, Lenhoff AM. Chromatography of proteins on charge-variant ion exchangers and implications for optimizing protein uptake rates. Journal of Chromatography. A. 1163: 190-202. PMID 17640661 DOI: 10.1016/J.Chroma.2007.06.028  0.77
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