Deborah J. Clegg - Publications

Affiliations: 
Internal Medicine University of Texas Southwestern Medical Center, Dallas, TX, United States 
Area:
hypothalamic regulation of adiposity

147 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Ortegon S, Giner P, Cruz B, Carcoba LM, Clapp B, Clegg DJ, O'Dell LE. Effectiveness of pharmacotherapies for diabetes on nicotine, food, and water intake in insulin-resistant rats. Advances in Drug and Alcohol Research. 3: 11812. PMID 38389818 DOI: 10.3389/adar.2023.11812  0.357
2020 Zidon TM, Padilla J, Fritsche KL, Welly RJ, McCabe LT, Stricklin OE, Frank AP, Park YM, Clegg DJ, Lubahn D, Kanaley J, Vieira-Potter V. Effects of ERβ and ERα on OVX-induced changes in adiposity and insulin resistance. The Journal of Endocrinology. PMID 32053493 DOI: 10.1530/Joe-19-0321  0.315
2019 Iyer MS, Paszkiewicz RL, Bergman RN, Richey JM, Woolcott OO, Asare Bediako I, Wu Q, Kim SP, Stefanovski D, Kolka CM, Clegg DJ, Kabir M. Activation of NPRs and UCP1-independent pathway following CB1R antagonist treatment is associated with adipose tissue beiging in fat-fed male dogs. American Journal of Physiology. Endocrinology and Metabolism. PMID 31237449 DOI: 10.1152/Ajpendo.00539.2018  0.391
2019 Fatima LA, Campello RS, Barreto-Andrade JN, Passarelli M, Clegg DJ, Machado UF. Estradiol stimulates adipogenesis and Slc2a4/GLUT4 expression via ESR1-mediated activation of CEBPA. Molecular and Cellular Endocrinology. 110447. PMID 31100494 DOI: 10.1016/J.Mce.2019.05.006  0.313
2019 Xu Y, Nedungadi TP, Zhu L, Sobhani N, Irani BG, Davis KE, Zhang X, Zou F, Gent LM, Hahner LD, Khan SA, Elias CF, Elmquist JK, Clegg DJ. Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction. Cell Metabolism. 29: 1232. PMID 31067449 DOI: 10.1016/J.Cmet.2019.04.006  0.307
2019 Clegg DJ, Hill Gallant KM. Plant-Based Diets in CKD. Clinical Journal of the American Society of Nephrology : Cjasn. 14: 141-143. PMID 30587492 DOI: 10.2215/Cjn.08960718  0.319
2019 PASZKIEWICZ RK, BERGMAN RN, FRANK A, WOOLCOTT OO, SOUZA SANTOS RD, IYER MS, CLEGG D, KABIR M. 1761-P: Brain-Restricted CB1-Receptor Antagonists Increase Oxygen Consumption Rate and Promote Beiging in 3T3-L1 Adipocytes Similar to Rimonabant Suggesting that Central Effects Can Be Avoided Diabetes. 68: 1761-P. DOI: 10.2337/Db19-1761-P  0.328
2018 Frank AP, de Souza Santos R, Palmer BF, Clegg DJ. Determinants of body fat distribution in humans may provide insight about obesity-related health risks. Journal of Lipid Research. PMID 30097511 DOI: 10.1194/Jlr.R086975  0.373
2018 PASZKIEWICZ RL, BERGMAN RN, RICHEY JM, IYER MS, WOOLCOTT OO, KOLKA CM, CLEGG D, KABIR M. Evidence of CB1-Receptor Antagonism in Fat-Fed Dogs Promoting Beiging of Adipose Tissue Mainly via Activation of Sarco/Endoplasmic Reticulum Ca2+ ATPase 2b and Ryanodine Receptor 2 Diabetes. 67: 2010-P. DOI: 10.2337/Db18-2010-P  0.319
2017 de Souza Santos R, Camargo RL, Vanzela EC, Batista TM, Morato PN, Leite NC, Rovani JC, García-Arévalo M, Clegg DJ, Carneiro EM. Diet-induced glucose homeostasis dysregulation is enhanced by taurine supplementation in ovariectomized mice. Amino Acids. PMID 29282544 DOI: 10.1007/S00726-017-2533-Z  0.41
2017 Fatima LA, Campello RS, Santos RS, Freitas HS, Frank AP, Machado UF, Clegg DJ. Estrogen receptor 1 (ESR1) regulates VEGFA in adipose tissue. Scientific Reports. 7: 16716. PMID 29196658 DOI: 10.1038/S41598-017-16686-7  0.319
2017 Frank AP, Palmer BF, Clegg DJ. Do estrogens enhance activation of brown and beiging of adipose tissues? Physiology & Behavior. PMID 28988965 DOI: 10.1016/J.Physbeh.2017.09.026  0.327
2017 Palmer BF, Clegg DJ. Non-shivering thermogenesis as a mechanism to facilitate sustainable weight loss. Obesity Reviews : An Official Journal of the International Association For the Study of Obesity. 18: 819-831. PMID 28547916 DOI: 10.1111/Obr.12563  0.326
2017 Clegg D, Hevener AL, Moreau KL, Morselli E, Criollo A, Van Pelt RE, Vieira-Potter VJ. Sex Hormones and Cardiometabolic Health: Role of Estrogen and Estrogen Receptors. Endocrinology. PMID 28323912 DOI: 10.1210/En.2016-1677  0.313
2016 Palmer BF, Clegg DJ. Physiology and pathophysiology of potassium homeostasis. Advances in Physiology Education. 40: 480-490. PMID 27756725 DOI: 10.1152/Advan.00121.2016  0.312
2016 Wang A, Luo J, Moore W, Alkhalidy H, Wu L, Zhang J, Zhen W, Wang Y, Clegg DJ, Bin Xu, Cheng Z, McMillan RP, Hulver MW, Liu D. GPR30 regulates diet-induced adiposity in female mice and adipogenesis in vitro. Scientific Reports. 6: 34302. PMID 27698362 DOI: 10.1038/Srep34302  0.478
2016 Santiago AM, Clegg DJ, Routh VH. Estrogens modulate ventrolateral ventromedial hypothalamic glucose-inhibited neurons. Molecular Metabolism. 5: 823-33. PMID 27688996 DOI: 10.1016/J.Molmet.2016.08.002  0.319
2016 Santiago AM, Clegg DJ, Routh VH. Ventromedial hypothalamic glucose sensing and glucose homeostasis vary throughout the estrous cycle. Physiology & Behavior. PMID 27666162 DOI: 10.1016/J.Physbeh.2016.09.021  0.301
2016 Rodriguez-Navas C, Morselli E, Clegg DJ. Sexually dimorphic brain fatty acid composition in low and high fat diet-fed mice. Molecular Metabolism. 5: 680-9. PMID 27656405 DOI: 10.1016/J.Molmet.2016.06.014  0.342
2016 Iyer MS, Bergman RN, Korman JE, Woolcott OO, Kabir M, Victor RG, Clegg DJ, Kolka C. Renal Denervation Reverses Hepatic Insulin Resistance Induced by High-Fat Diet. Diabetes. PMID 27495220 DOI: 10.2337/Db16-0698  0.375
2016 Santos RS, Batista TM, Camargo RL, Morato PN, Borck PC, Leite NC, Kurauti MA, Wanschel AC, Nadal Á, Clegg DJ, Carneiro EM. "Lacking of estradiol reduces insulin exocytosis from pancreatic β-cells and increases hepatic insulin degradation". Steroids. PMID 27192429 DOI: 10.1016/J.Steroids.2016.05.002  0.388
2016 Frank AP, Clegg DJ. JAMA PATIENT PAGE. Dietary Guidelines for Americans--Eat Less Fat. Jama. 315: 1919. PMID 27139076 DOI: 10.1001/Jama.2016.0972  0.383
2016 Saito K, He Y, Yang Y, Zhu L, Wang C, Xu P, Hinton AO, Yan X, Zhao J, Fukuda M, Tong Q, Clegg DJ, Xu Y. PI3K in the ventromedial hypothalamic nucleus mediates estrogenic actions on energy expenditure in female mice. Scientific Reports. 6: 23459. PMID 26988598 DOI: 10.1038/Srep23459  0.382
2016 Frank AP, Clegg DJ. JAMA PATIENT PAGE. Dietary Guidelines for Americans--Eat Less Sugar. Jama. 315: 1196. PMID 26978223 DOI: 10.1001/Jama.2016.0968  0.306
2016 Kim JS, Rizwan MZ, Clegg DJ, Anderson GM. Leptin Signaling is not Required for Anorexigenic Estradiol Effects in Female Mice. Endocrinology. en20151594. PMID 26937712 DOI: 10.1210/En.2015-1594  0.405
2016 Stout MB, Steyn FJ, Jurczak MJ, Camporez JG, Zhu Y, Hawse JR, Jurk D, Palmer AK, Xu M, Pirtskhalava T, Evans GL, de Souza Santos R, Frank AP, White TA, Monroe DG, ... ... Clegg DJ, et al. 17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 26809497 DOI: 10.1093/Gerona/Glv309  0.318
2015 Frank AP, Zechner JF, Clegg DJ. Gastric Bypass Surgery but not Caloric Restriction Improves Reproductive Function in Obese Mice. Obesity Surgery. PMID 26667161 DOI: 10.1007/S11695-015-2009-8  0.375
2015 Zhu L, Xu P, Cao X, Yang Y, Hinton AO, Xia Y, Saito K, Yan X, Zou F, Ding H, Wang C, Yan C, Saha P, Khan SA, Zhao J, ... ... Clegg DJ, et al. The ERα-PI3K Cascade in Pro-opiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice. Endocrinology. en20151660. PMID 26375425 DOI: 10.1210/En.2015-1660  0.439
2015 Xu P, Cao X, He Y, Zhu L, Yang Y, Saito K, Wang C, Yan X, Hinton AO, Zou F, Ding H, Xia Y, Yan C, Shu G, Wu SP, ... ... Clegg DJ, et al. Estrogen receptor-α in medial amygdala neurons regulates body weight. The Journal of Clinical Investigation. 125: 2861-76. PMID 26098212 DOI: 10.1172/Jci80941  0.434
2015 Morselli E, Frank AP, Palmer BF, Rodriguez-Navas C, Criollo A, Clegg DJ. A sexually dimorphic hypothalamic response to chronic high-fat diet consumption. International Journal of Obesity (2005). PMID 26073655 DOI: 10.1038/Ijo.2015.114  0.389
2015 Hevener AL, Clegg DJ, Mauvais-Jarvis F. Impaired estrogen receptor action in the pathogenesis of the metabolic syndrome. Molecular and Cellular Endocrinology. PMID 26033249 DOI: 10.1016/J.Mce.2015.05.020  0.325
2015 Neinast MD, Frank AP, Zechner JF, Li Q, Vishvanath L, Palmer BF, Aguirre V, Gupta RK, Clegg DJ. Activation of natriuretic peptides and the sympathetic nervous system following Roux-en-Y gastric bypass is associated with gonadal adipose tissues browning. Molecular Metabolism. 4: 427-36. PMID 25973390 DOI: 10.1016/J.Molmet.2015.02.006  0.411
2015 Palmer BF, Clegg DJ. The sexual dimorphism of obesity. Molecular and Cellular Endocrinology. 402: 113-9. PMID 25578600 DOI: 10.1016/J.Mce.2014.11.029  0.376
2014 Morselli E, Criollo A, Rodriguez-Navas C, Clegg DJ. Chronic High Fat Diet Consumption Impairs Metabolic Health of Male Mice. Inflammation and Cell Signaling. 1: e561. PMID 26046098 DOI: 10.14800/Ics.561  0.414
2014 Morselli E, Fuente-Martin E, Finan B, Kim M, Frank A, Garcia-Caceres C, Navas CR, Gordillo R, Neinast M, Kalainayakan SP, Li DL, Gao Y, Yi CX, Hahner L, Palmer BF, ... Clegg DJ, et al. Hypothalamic PGC-1α protects against high-fat diet exposure by regulating ERα. Cell Reports. 9: 633-45. PMID 25373903 DOI: 10.1016/J.Celrep.2014.09.025  0.373
2014 Cao X, Xu P, Oyola MG, Xia Y, Yan X, Saito K, Zou F, Wang C, Yang Y, Hinton A, Yan C, Ding H, Zhu L, Yu L, Yang B, ... Clegg DJ, et al. Estrogens stimulate serotonin neurons to inhibit binge-like eating in mice. The Journal of Clinical Investigation. 124: 4351-62. PMID 25157819 DOI: 10.1172/Jci74726  0.321
2014 Frank A, Brown LM, Clegg DJ. The role of hypothalamic estrogen receptors in metabolic regulation. Frontiers in Neuroendocrinology. 35: 550-7. PMID 24882636 DOI: 10.1016/J.Yfrne.2014.05.002  0.787
2014 Picard A, Rouch C, Kassis N, Moullé VS, Croizier S, Denis RG, Castel J, Coant N, Davis K, Clegg DJ, Benoit SC, Prévot V, Bouret S, Luquet S, Le Stunff H, et al. Hippocampal lipoprotein lipase regulates energy balance in rodents. Molecular Metabolism. 3: 167-76. PMID 24634821 DOI: 10.1016/J.Molmet.2013.11.002  0.743
2014 Davis KE, Carstens EJ, Irani BG, Gent LM, Hahner LM, Clegg DJ. Sexually dimorphic role of G protein-coupled estrogen receptor (GPER) in modulating energy homeostasis. Hormones and Behavior. 66: 196-207. PMID 24560890 DOI: 10.1016/J.Yhbeh.2014.02.004  0.448
2014 Palmer BF, Clegg DJ. Ascent to altitude as a weight loss method: the good and bad of hypoxia inducible factor activation. Obesity (Silver Spring, Md.). 22: 311-7. PMID 23625659 DOI: 10.1002/Oby.20499  0.397
2014 Reizes O, Benoit SC, Clegg DJ. Neuroregulation of appetite Treatment of the Obese Patient. 3-22. DOI: 10.1007/978-1-4939-1203-2_1  0.715
2013 Davis KE, D Neinast M, Sun K, M Skiles W, D Bills J, A Zehr J, Zeve D, D Hahner L, W Cox D, M Gent L, Xu Y, V Wang Z, A Khan S, Clegg DJ. The sexually dimorphic role of adipose and adipocyte estrogen receptors in modulating adipose tissue expansion, inflammation, and fibrosis. Molecular Metabolism. 2: 227-42. PMID 24049737 DOI: 10.1016/J.Molmet.2013.05.006  0.34
2013 Fuente-Martin E, Garcia-Caceres C, Morselli E, Clegg DJ, Chowen JA, Finan B, Brinton RD, Tschöp MH. Estrogen, astrocytes and the neuroendocrine control of metabolism. Reviews in Endocrine & Metabolic Disorders. 14: 331-8. PMID 24009071 DOI: 10.1007/S11154-013-9263-7  0.368
2013 Mauvais-Jarvis F, Clegg DJ, Hevener AL. The role of estrogens in control of energy balance and glucose homeostasis. Endocrine Reviews. 34: 309-38. PMID 23460719 DOI: 10.1210/Er.2012-1055  0.429
2013 Brown LM, Clegg DJ. Estrogen and leptin regulation of endocrinological features of anorexia nervosa. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 237. PMID 23147480 DOI: 10.1038/Npp.2012.176  0.772
2012 Clegg DJ. Minireview: the year in review of estrogen regulation of metabolism. Molecular Endocrinology (Baltimore, Md.). 26: 1957-60. PMID 23051593 DOI: 10.1210/Me.2012-1284  0.454
2012 Castañeda TR, Abplanalp W, Um SH, Pfluger PT, Schrott B, Brown K, Grant E, Carnevalli L, Benoit SC, Morgan DA, Gilham D, Hui DY, Rahmouni K, Thomas G, Kozma SC, Clegg DJ, et al. Metabolic control by S6 kinases depends on dietary lipids. Plos One. 7: e32631. PMID 22412899 DOI: 10.1371/Journal.Pone.0032631  0.73
2012 Krikorian R, Shidler MD, Dangelo K, Couch SC, Benoit SC, Clegg DJ. Dietary ketosis enhances memory in mild cognitive impairment. Neurobiology of Aging. 33: 425.e19-27. PMID 21130529 DOI: 10.1016/J.Neurobiolaging.2010.10.006  0.7
2012 Xu Y, Nedungadiuli T, Gent L, Elias C, Elmquist JK, Clegg D. It's ALL in the Hypothalamus! Sex, Reproduction, and Obesity. Biology of Reproduction. 87: 34-34. DOI: 10.1093/Biolreprod/87.S1.34  0.306
2011 Speakman JR, Levitsky DA, Allison DB, Bray MS, de Castro JM, Clegg DJ, Clapham JC, Dulloo AG, Gruer L, Haw S, Hebebrand J, Hetherington MM, Higgs S, Jebb SA, Loos RJ, et al. Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity. Disease Models & Mechanisms. 4: 733-45. PMID 22065844 DOI: 10.1242/Dmm.008698  0.411
2011 Xu Y, Nedungadi TP, Zhu L, Sobhani N, Irani BG, Davis KE, Zhang X, Zou F, Gent LM, Hahner LD, Khan SA, Elias CF, Elmquist JK, Clegg DJ. Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction. Cell Metabolism. 14: 453-65. PMID 21982706 DOI: 10.1016/J.Cmet.2011.08.009  0.366
2011 Kilpeläinen TO, Zillikens MC, Stančákova A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J, Vandenput L, Styrkarsdottir U, Zhou Y, Smith AV, Zhao JH, Amin N, ... Clegg DJ, et al. Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nature Genetics. 43: 753-60. PMID 21706003 DOI: 10.1038/Ng.866  0.378
2011 Holland WL, Bikman BT, Wang LP, Yuguang G, Sargent KM, Bulchand S, Knotts TA, Shui G, Clegg DJ, Wenk MR, Pagliassotti MJ, Scherer PE, Summers SA. Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. The Journal of Clinical Investigation. 121: 1858-70. PMID 21490391 DOI: 10.1172/Jci43378  0.345
2011 Meyer MR, Clegg DJ, Prossnitz ER, Barton M. Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors. Acta Physiologica (Oxford, England). 203: 259-69. PMID 21281456 DOI: 10.1111/J.1748-1716.2010.02237.X  0.381
2011 Park CJ, Zhao Z, Glidewell-Kenney C, Lazic M, Chambon P, Krust A, Weiss J, Clegg DJ, Dunaif A, Jameson JL, Levine JE. Genetic rescue of nonclassical ERα signaling normalizes energy balance in obese Erα-null mutant mice. The Journal of Clinical Investigation. 121: 604-12. PMID 21245576 DOI: 10.1172/Jci41702  0.385
2011 Clegg DJ, Gotoh K, Kemp C, Wortman MD, Benoit SC, Brown LM, D'Alessio D, Tso P, Seeley RJ, Woods SC. Consumption of a high-fat diet induces central insulin resistance independent of adiposity. Physiology & Behavior. 103: 10-6. PMID 21241723 DOI: 10.1016/J.Physbeh.2011.01.010  0.835
2011 Irani BG, Xiang Z, Yarandi HN, Holder JR, Moore MC, Bauzo RM, Proneth B, Shaw AM, Millard WJ, Chambers JB, Benoit SC, Clegg DJ, Haskell-Luevano C. Implication of the melanocortin-3 receptor in the regulation of food intake. European Journal of Pharmacology. 660: 80-7. PMID 21199647 DOI: 10.1016/J.Ejphar.2010.10.101  0.762
2011 Davis JF, Choi DL, Clegg DJ, Benoit SC. Signaling through the ghrelin receptor modulates hippocampal function and meal anticipation in mice. Physiology & Behavior. 103: 39-43. PMID 21036184 DOI: 10.1016/J.Physbeh.2010.10.017  0.737
2011 Davis JF, Choi DL, Schurdak JD, Fitzgerald MF, Clegg DJ, Lipton JW, Figlewicz DP, Benoit SC. Leptin regulates energy balance and motivation through action at distinct neural circuits. Biological Psychiatry. 69: 668-74. PMID 21035790 DOI: 10.1016/J.Biopsych.2010.08.028  0.793
2011 Ford J, Hajibeigi A, Long M, Hahner L, Gore C, Hsieh JT, Clegg D, Zerwekh J, Öz OK. GPR30 deficiency causes increased bone mass, mineralization, and growth plate proliferative activity in male mice Journal of Bone and Mineral Research. 26: 298-307. PMID 20734455 DOI: 10.1002/Jbmr.209  0.314
2011 Benoit SC, Kemp CJ, Elias CF, Abplanalp W, Herman JP, Migrenne S, Lefevre AL, Cruciani-Guglielmacci C, Magnan C, Yu F, Niswender K, Irani BG, Holland WL, Clegg DJ. Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents (Journal of Clinical Investigation (2010) 120, 1 (394) DOI: 10.1172/JCI36714C1) Journal of Clinical Investigation. 121: 456. DOI: 10.1172/Jci45846  0.699
2010 Zheng Q, Zhu J, Shanabrough M, Borok E, Benoit SC, Horvath TL, Clegg DJ, Reizes O. Enhanced anorexigenic signaling in lean obesity resistant syndecan-3 null mice. Neuroscience. 171: 1032-40. PMID 20923696 DOI: 10.1016/J.Neuroscience.2010.09.060  0.75
2010 Irani BG, Donato J, Olson DP, Lowell BB, Sacktor TC, Reyland ME, Tolson KP, Zinn AR, Ueta Y, Sakata I, Zigman JM, Elias CF, Clegg DJ. Distribution and neurochemical characterization of protein kinase C-theta and -delta in the rodent hypothalamus. Neuroscience. 170: 1065-79. PMID 20691763 DOI: 10.1016/J.Neuroscience.2010.07.064  0.325
2010 Brown LM, Gent L, Davis K, Clegg DJ. Metabolic impact of sex hormones on obesity. Brain Research. 1350: 77-85. PMID 20441773 DOI: 10.1016/J.Brainres.2010.04.056  0.786
2010 Shi H, Sorrell JE, Clegg DJ, Woods SC, Seeley RJ. The roles of leptin receptors on POMC neurons in the regulation of sex-specific energy homeostasis. Physiology & Behavior. 100: 165-72. PMID 20193700 DOI: 10.1016/J.Physbeh.2010.02.018  0.668
2010 Davidson TL, Kanoski SE, Chan K, Clegg DJ, Benoit SC, Jarrard LE. Hippocampal lesions impair retention of discriminative responding based on energy state cues. Behavioral Neuroscience. 124: 97-105. PMID 20141284 DOI: 10.1037/A0018402  0.747
2010 Brown LM, Clegg DJ. Central effects of estradiol in the regulation of food intake, body weight, and adiposity. The Journal of Steroid Biochemistry and Molecular Biology. 122: 65-73. PMID 20035866 DOI: 10.1016/J.Jsbmb.2009.12.005  0.779
2010 Jessen L, Clegg DJ, Bouman SD. Evaluation of the lack of anorectic effect of intracerebroventricular insulin in rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 298: R43-50. PMID 19864335 DOI: 10.1152/Ajpregu.90736.2008  0.484
2010 Benoit SC, Kemp CJ, Elias CF, Abplanalp W, Herman JP, Migrenne S, Lefevre AL, Cruciani-Guglielmacci C, Magnan C, Yu F, Niswender K, Irani BG, Holland WL, Clegg DJ. Palmitic acid mediates hypothalamic insulin resistance by altering PKC-q subcellular localization in rodents (Journal of Clinical Investigation (2009) 119, (2577-2589)) Journal of Clinical Investigation. 120: 394. DOI: 10.1172/Jci36714C1  0.696
2010 Miller C, Clegg D, Cooney P, Brown L. Sex differences in diet-induced obesity and central leptin sensitivity in middle-aged rats Appetite. 54: 664. DOI: 10.1016/J.Appet.2010.04.141  0.765
2010 Miller C, Clegg D, Cooney P, Brown L. Proestrus rats have reduced inflammation and ER stress in the liver after 72h on a high fat diet Appetite. 54: 664. DOI: 10.1016/J.Appet.2010.04.140  0.744
2009 Nedungadi TP, Clegg DJ. Sexual dimorphism in body fat distribution and risk for cardiovascular diseases. Journal of Cardiovascular Translational Research. 2: 321-7. PMID 20560019 DOI: 10.1007/S12265-009-9101-1  0.424
2009 Benoit SC, Kemp CJ, Elias CF, Abplanalp W, Herman JP, Migrenne S, Lefevre AL, Cruciani-Guglielmacci C, Magnan C, Yu F, Niswender K, Irani BG, Holland WL, Clegg DJ. Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents. The Journal of Clinical Investigation. 119: 2577-89. PMID 19726875 DOI: 10.1172/Jci36714  0.75
2009 Wang HH, Liu M, Clegg DJ, Portincasa P, Wang DQ. New insights into the molecular mechanisms underlying effects of estrogen on cholesterol gallstone formation. Biochimica Et Biophysica Acta. 1791: 1037-47. PMID 19589396 DOI: 10.1016/J.Bbalip.2009.06.006  0.32
2009 Medvedovic M, Gear R, Freudenberg JM, Schneider J, Bornschein R, Yan M, Mistry MJ, Hendrix H, Karyala S, Halbleib D, Heffelfinger S, Clegg DJ, Anderson MW. Influence of fatty acid diets on gene expression in rat mammary epithelial cells. Physiological Genomics. 38: 80-8. PMID 19351911 DOI: 10.1152/Physiolgenomics.00007.2009  0.34
2009 Shi H, Seeley RJ, Clegg DJ. Sexual differences in the control of energy homeostasis. Frontiers in Neuroendocrinology. 30: 396-404. PMID 19341761 DOI: 10.1016/J.Yfrne.2009.03.004  0.577
2009 Shi H, Clegg DJ. Sex differences in the regulation of body weight. Physiology & Behavior. 97: 199-204. PMID 19250944 DOI: 10.1016/J.Physbeh.2009.02.017  0.486
2009 Haas E, Bhattacharya I, Brailoiu E, Damjanović M, Brailoiu GC, Gao X, Mueller-Guerre L, Marjon NA, Gut A, Minotti R, Meyer MR, Amann K, Ammann E, Perez-Dominguez A, Genoni M, Clegg DJ, et al. Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity. Circulation Research. 104: 288-91. PMID 19179659 DOI: 10.1161/Circresaha.108.190892  0.313
2009 Posey KA, Clegg DJ, Printz RL, Byun J, Morton GJ, Vivekanandan-Giri A, Pennathur S, Baskin DG, Heinecke JW, Woods SC, Schwartz MW, Niswender KD. Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. American Journal of Physiology. Endocrinology and Metabolism. 296: E1003-12. PMID 19116375 DOI: 10.1152/Ajpendo.90377.2008  0.653
2009 Davidson TL, Chan K, Jarrard LE, Kanoski SE, Clegg DJ, Benoit SC. Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation. Hippocampus. 19: 235-52. PMID 18831000 DOI: 10.1002/Hipo.20499  0.746
2009 Shertzer HG, Schneider SN, Kendig EL, Clegg DJ, D'Alessio DA, Johansson E, Genter MB. Tetrahydroindenoindole inhibits the progression of diabetes in mice. Chemico-Biological Interactions. 177: 71-80. PMID 18823964 DOI: 10.1016/J.Cbi.2008.09.001  0.391
2009 Divanovic S, Trompette A, Pfluger PT, Weisberg SP, Harley IT, Flick LM, Allen JL, Clegg DJ, Seeley RJ, Tschöp MH, Karp CL. Regulation of energy metabolism by the RP105/TLR axis Cytokine. 48: 103. DOI: 10.1016/J.Cyto.2009.07.434  0.468
2009 Ford J, Hajibeigi A, Getachew M, Liu J, Clegg D, Oz O. Loss of function of the non-genomic estrogen receptor GPR30 causes increased body size, percent body fat, and bone mass in adult male mice Bone. 44: S62-S63. DOI: 10.1016/J.Bone.2009.01.030  0.342
2009 Tracy A, Clegg D, Tschoep M, Benoit S. Differential effects of ghrelin on spatial learning in males and females Appetite. 52: 862. DOI: 10.1016/J.Appet.2009.04.195  0.667
2009 Shi H, Davis J, Woods S, Seeley R, Clegg D, Benoit S. Estrogen enhances sucrose pellet reinforcement Appetite. 52: 857. DOI: 10.1016/J.Appet.2009.04.177  0.76
2009 Davis JF, Choi DL, Fitzgerald ME, Shurdak JD, Clegg DJ, Lipton JW, Figlewicz DP, Benoit SC. Inhibition of midbrain leptin receptor expression augments sucrose reinforced behavior and mesolimbic dopamine in the rat Appetite. 52: 825. DOI: 10.1016/J.Appet.2009.04.046  0.701
2009 Brown L, Cooney P, Miller C, Clegg D. Proestrus rats on a high-fat diet have less central inflammation than male rats Appetite. 52: 821. DOI: 10.1016/J.Appet.2009.04.031  0.764
2008 Davis JF, Tracy AL, Schurdak JD, Tschöp MH, Lipton JW, Clegg DJ, Benoit SC. Exposure to elevated levels of dietary fat attenuates psychostimulant reward and mesolimbic dopamine turnover in the rat. Behavioral Neuroscience. 122: 1257-63. PMID 19045945 DOI: 10.1037/A0013111  0.745
2008 Benoit SC, Tracy AL, Davis JF, Choi D, Clegg DJ. Novel functions of orexigenic hypothalamic peptides: from genes to behavior. Nutrition (Burbank, Los Angeles County, Calif.). 24: 843-7. PMID 18725081 DOI: 10.1016/J.Nut.2008.06.028  0.735
2008 Shen L, Tso P, Woods SC, Clegg DJ, Barber KL, Carey K, Liu M. Brain apolipoprotein E: an important regulator of food intake in rats. Diabetes. 57: 2092-8. PMID 18559657 DOI: 10.2337/Db08-0291  0.634
2008 Kendig EL, Schneider SN, Clegg DJ, Genter MB, Shertzer HG. Over-the-counter analgesics normalize blood glucose and body composition in mice fed a high fat diet. Biochemical Pharmacology. 76: 216-24. PMID 18554574 DOI: 10.1016/J.Bcp.2008.05.001  0.39
2008 Shertzer HG, Schneider SN, Kendig EL, Clegg DJ, D'Alessio DA, Genter MB. Acetaminophen normalizes glucose homeostasis in mouse models for diabetes. Biochemical Pharmacology. 75: 1402-10. PMID 18237716 DOI: 10.1016/J.Bcp.2007.12.003  0.365
2008 Tracy AL, Clegg DJ, Johnson JD, Davidson TL, Benoit SC. The melanocortin antagonist AgRP (83-132) increases appetitive responding for a fat, but not a carbohydrate, reinforcer. Pharmacology, Biochemistry, and Behavior. 89: 263-71. PMID 18234306 DOI: 10.1016/J.Pbb.2007.12.018  0.776
2008 Kemp CJ, D'Alessio DA, Scott RO, Kelm GR, Meller ST, Barrera JG, Seeley RJ, Clegg DJ, Benoit SC. Voluntary consumption of ethyl oleate reduces food intake and body weight in rats. Physiology & Behavior. 93: 912-8. PMID 18234242 DOI: 10.1016/J.Physbeh.2007.12.008  0.814
2008 Eric Hu X, Wos JA, Dowty ME, Suchanek PM, Ji W, Chambers JB, Benoit SC, Clegg DJ, Reizes O. Small-molecule melanin-concentrating hormone-1 receptor antagonists require brain penetration for inhibition of food intake and reduction in body weight. The Journal of Pharmacology and Experimental Therapeutics. 324: 206-13. PMID 17932246 DOI: 10.1124/Jpet.107.130435  0.768
2008 Reizes O, Benoit SC, Clegg DJ. The role of syndecans in the regulation of body weight and synaptic plasticity. The International Journal of Biochemistry & Cell Biology. 40: 28-45. PMID 17698399 DOI: 10.1016/J.Biocel.2007.06.011  0.732
2008 Shen L, Tso P, Woods S, Clegg D, Barber K, Carey K, Liu M. Brain apolipoprotein E: An important regulator of food intake and body weight Appetite. 51: 399. DOI: 10.1016/J.Appet.2008.04.220  0.618
2008 Brown L, Clegg D, Benoit S, Woods S. Central administration of an NFκB antagonist prior to insulin reduces food intake and body weight in rats on a high-fat diet Appetite. 51: 356. DOI: 10.1016/J.Appet.2008.04.046  0.849
2007 Davidson TL, Kanoski SE, Schier LA, Clegg DJ, Benoit SC. A potential role for the hippocampus in energy intake and body weight regulation. Current Opinion in Pharmacology. 7: 613-6. PMID 18032108 DOI: 10.1016/J.Coph.2007.10.008  0.762
2007 Davis JF, Melhorn SJ, Shurdak JD, Heiman JU, Tschöp MH, Clegg DJ, Benoit SC. Comparison of hydrogenated vegetable shortening and nutritionally complete high-fat diet on limited access-binge behavior in rats. Physiology & Behavior. 92: 924-30. PMID 17689576 DOI: 10.1016/J.Physbeh.2007.06.024  0.751
2007 Musatov S, Chen W, Pfaff DW, Mobbs CV, Yang XJ, Clegg DJ, Kaplitt MG, Ogawa S. Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome. Proceedings of the National Academy of Sciences of the United States of America. 104: 2501-6. PMID 17284595 DOI: 10.1073/Pnas.0610787104  0.5
2007 Clegg DJ, Brown LM, Zigman JM, Kemp CJ, Strader AD, Benoit SC, Woods SC, Mangiaracina M, Geary N. Estradiol-dependent decrease in the orexigenic potency of ghrelin in female rats. Diabetes. 56: 1051-8. PMID 17251274 DOI: 10.2337/Db06-0015  0.837
2007 Brown LM, Benoit SC, Woods SC, Clegg DJ. Intraventricular (i3vt) ghrelin increases food intake in fatty Zucker rats. Peptides. 28: 612-6. PMID 17196305 DOI: 10.1016/J.Peptides.2006.11.012  0.83
2007 Kemp C, Caldwell-lawson J, Clegg D, Benoit S. Interaction of MMP-3 and sex hormones in the control of energy balance. Appetite. 49: 303. DOI: 10.1016/J.Appet.2007.03.106  0.735
2007 Heiman J, Davis J, Tracy A, Moore R, Zigman J, Clegg D, Benoit S. Mice lacking the ghrelin receptor (GHS-R -/-) exhibit impaired hippocampal-dependent learning. Appetite. 49: 297. DOI: 10.1016/J.Appet.2007.03.087  0.361
2007 Choi D, Davis J, Clegg D, Benoit S. Mice exhibit enhanced macronutrient-specific conditioned place preference under hypocaloric conditions. Appetite. 49: 284. DOI: 10.1016/J.Appet.2007.03.048  0.734
2007 Chambers J, Schurdak J, Benoit S, Clegg D. Behavioral and metabolic phenotyping of GPR30 and neuronal estrogen receptor-α knockout mice. Appetite. 49: 283. DOI: 10.1016/J.Appet.2007.03.045  0.747
2007 Abplanalp W, Clegg D. Translocation of PKC theta by fatty acids causes hypothalamic insulin resistance. Appetite. 49: 274. DOI: 10.1016/J.Appet.2007.03.018  0.476
2007 Benoit SC, Clegg DJ, Woods SC. Energy balance and feeding Handbook of Neurochemistry and Molecular Neurobiology: Behavioral Neurochemistry, Neuroendocrinology and Molecular Neurobiology. 619-640. DOI: 10.1007/978-0-387-30405-2_16  0.715
2006 Duncan EA, Rider TR, Jandacek RJ, Clegg DJ, Benoit SC, Tso P, Woods SC. The regulation of alcohol intake by melanin-concentrating hormone in rats. Pharmacology, Biochemistry, and Behavior. 85: 728-35. PMID 17188345 DOI: 10.1016/J.Pbb.2006.11.004  0.716
2006 Brown LM, Clegg DJ, Benoit SC, Woods SC. Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice. Physiology & Behavior. 89: 687-91. PMID 16979194 DOI: 10.1016/J.Physbeh.2006.08.008  0.842
2006 McNamara RK, Ostrander M, Abplanalp W, Richtand NM, Benoit SC, Clegg DJ. Modulation of phosphoinositide-protein kinase C signal transduction by omega-3 fatty acids: implications for the pathophysiology and treatment of recurrent neuropsychiatric illness. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 75: 237-57. PMID 16935483 DOI: 10.1016/J.Plefa.2006.07.009  0.657
2006 Clegg DJ, Brown LM, Woods SC, Benoit SC. Gonadal hormones determine sensitivity to central leptin and insulin. Diabetes. 55: 978-87. PMID 16567519 DOI: 10.2337/Diabetes.55.04.06.Db05-1339  0.806
2006 Reizes O, Clegg DJ, Strader AD, Benoit SC. A role for syndecan-3 in the melanocortin regulation of energy balance. Peptides. 27: 274-80. PMID 16289473 DOI: 10.1016/J.Peptides.2005.02.030  0.699
2006 Gotoh K, Liu M, Benoit SC, Clegg DJ, Davidson WS, D'Alessio D, Seeley RJ, Tso P, Woods SC. Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 290: R202-7. PMID 16166201 DOI: 10.1152/Ajpregu.00502.2005  0.796
2006 Woods SC, Benoit SC, Clegg DJ. The brain-gut-islet connection Diabetes. 55: S114-S121. DOI: 10.2337/Db06-S015  0.796
2006 Strader AD, Clegg DJ, Shi H, Chambers JB, Sorrell JE, Seeley RJ, Woods SC. WITHDRAWN: The leptin driven melanocortin pathway in the regulation of body fat and glucose homeostasis is sexually dimorphic Appetite. DOI: 10.1016/J.Appet.2006.03.291  0.542
2005 Reed JA, Clegg DJ, Smith KB, Tolod-Richer EG, Matter EK, Picard LS, Seeley RJ. GM-CSF action in the CNS decreases food intake and body weight. The Journal of Clinical Investigation. 115: 3035-44. PMID 16276414 DOI: 10.1172/Jci25681  0.609
2005 Ogawa R, Strader AD, Clegg DJ, Sakai RR, Seeley RJ, Woods SC. Chronic food restriction and reduced dietary fat: risk factors for bouts of overeating. Physiology & Behavior. 86: 578-85. PMID 16176825 DOI: 10.1016/J.Physbeh.2005.08.028  0.71
2005 Davidson TL, Kanoski SE, Tracy AL, Walls EK, Clegg D, Benoit SC. The interoceptive cue properties of ghrelin generalize to cues produced by food deprivation. Peptides. 26: 1602-10. PMID 16112399 DOI: 10.1016/J.Peptides.2005.02.014  0.728
2005 Otto B, Spranger J, Benoit SC, Clegg DJ, Tschöp MH. The many faces of ghrelin: new perspectives for nutrition research? The British Journal of Nutrition. 93: 765-71. PMID 16022744 DOI: 10.1079/Bjn20051446  0.727
2005 Benoit SC, Clegg DJ, Woods SC, Seeley RJ. The role of previous exposure in the appetitive and consummatory effects of orexigenic neuropeptides. Peptides. 26: 751-7. PMID 15808905 DOI: 10.1016/J.Peptides.2004.12.012  0.81
2005 Clegg DJ, Benoit SC, Reed JA, Woods SC, Dunn-Meynell A, Levin BE. Reduced anorexic effects of insulin in obesity-prone rats fed a moderate-fat diet. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 288: R981-6. PMID 15604298 DOI: 10.1152/Ajpregu.00675.2004  0.807
2004 Woods SC, D'Alessio DA, Tso P, Rushing PA, Clegg DJ, Benoit SC, Gotoh K, Liu M, Seeley RJ. Consumption of a high-fat diet alters the homeostatic regulation of energy balance. Physiology & Behavior. 83: 573-8. PMID 15621062 DOI: 10.1016/J.Physbeh.2004.07.026  0.824
2004 Clegg DJ, Woods SC. The physiology of obesity. Clinical Obstetrics and Gynecology. 47: 967-79; discussion 9. PMID 15596949 DOI: 10.1097/01.Grf.0000135355.25879.41  0.476
2004 Woods SC, Benoit SC, Clegg DJ, Seeley RJ. Clinical endocrinology and metabolism. Regulation of energy homeostasis by peripheral signals. Best Practice & Research. Clinical Endocrinology & Metabolism. 18: 497-515. PMID 15533772 DOI: 10.1016/J.Beem.2004.08.004  0.82
2004 Seeley RJ, Drazen DL, Clegg DJ. The critical role of the melanocortin system in the control of energy balance. Annual Review of Nutrition. 24: 133-49. PMID 15189116 DOI: 10.1146/Annurev.Nutr.24.012003.132428  0.804
2004 Benoit SC, Clegg DJ, Seeley RJ, Woods SC. Insulin and leptin as adiposity signals. Recent Progress in Hormone Research. 59: 267-85. PMID 14749506 DOI: 10.1210/Rp.59.1.267  0.822
2004 Niswender KD, Clegg DJ, Morrison CD, Morton GJ, Benoit SC. The human obesity epidemic - A physiological perspective Current Medicinal Chemistry: Immunology, Endocrine and Metabolic Agents. 4: 91-104. DOI: 10.2174/1568013043357824  0.66
2003 Drazen DL, Wortman MD, Schwartz MW, Clegg DJ, van Dijk G, Woods SC, Seeley RJ. Adrenalectomy alters the sensitivity of the central nervous system melanocortin system. Diabetes. 52: 2928-34. PMID 14633853 DOI: 10.2337/Diabetes.52.12.2928  0.832
2003 Woods SC, Gotoh K, Clegg DJ. Gender differences in the control of energy homeostasis. Experimental Biology and Medicine (Maywood, N.J.). 228: 1175-80. PMID 14610257 DOI: 10.1177/153537020322801012  0.616
2003 Benoit SC, Clegg DJ, Barrera JG, Seeley RJ, Woods SC. Learned meal initiation attenuates the anorexic effects of the melanocortin agonist MTII. Diabetes. 52: 2684-8. PMID 14578286 DOI: 10.2337/Diabetes.52.11.2684  0.833
2003 Reizes O, Benoit SC, Strader AD, Clegg DJ, Akunuru S, Seeley RJ. Syndecan-3 modulates food intake by interacting with the melanocortin/AgRP pathway. Annals of the New York Academy of Sciences. 994: 66-73. PMID 12851299 DOI: 10.1111/J.1749-6632.2003.Tb03163.X  0.802
2003 Clegg DJ, Benoit SC, Air EL, Jackman A, Tso P, D'Alessio D, Woods SC, Seeley RJ. Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII. Endocrinology. 144: 2941-6. PMID 12810549 DOI: 10.1210/En.2002-0218  0.844
2003 Wortman MD, Clegg DJ, D'Alessio D, Woods SC, Seeley RJ. C75 inhibits food intake by increasing CNS glucose metabolism. Nature Medicine. 9: 483-5. PMID 12724740 DOI: 10.1038/Nm0503-483  0.769
2003 Benoit SC, McQuade JA, Clegg DJ, Xu M, Rushing PA, Woods SC, Seeley RJ. Altered feeding responses in mice with targeted disruption of the dopamine-3 receptor gene. Behavioral Neuroscience. 117: 46-54. PMID 12619907 DOI: 10.1037/0735-7044.117.1.46  0.803
2003 Clegg DJ, Riedy CA, Smith KA, Benoit SC, Woods SC. Differential sensitivity to central leptin and insulin in male and female rats. Diabetes. 52: 682-7. PMID 12606509 DOI: 10.2337/Diabetes.52.3.682  0.819
2003 Clegg DJ, Edwards GL, Martin RJ. Central insulin potentiates eating elicited by 2-deoxy-D-glucose. Physiology & Behavior. 78: 331-6. PMID 12576132 DOI: 10.1016/S0031-9384(02)01000-4  0.483
2003 Clegg DJ, Air EL, Benoit SC, Sakai RS, Seeley RJ, Woods SC. Intraventricular melanin-concentrating hormone stimulates water intake independent of food intake. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 284: R494-9. PMID 12557891 DOI: 10.1152/Ajpregu.00399.2002  0.811
2003 Niswender KD, Morrison CD, Clegg DJ, Olson R, Baskin DG, Myers MG, Seeley RJ, Schwartz MW. Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes. 52: 227-31. PMID 12540590 DOI: 10.2337/Diabetes.52.2.227  0.569
2002 Clegg DJ, Wortman MD, Benoit SC, McOsker CC, Seeley RJ. Comparison of central and peripheral administration of C75 on food intake, body weight, and conditioned taste aversion. Diabetes. 51: 3196-201. PMID 12401710 DOI: 10.2337/Diabetes.51.11.3196  0.823
2002 Brugman S, Clegg DJ, Woods SC, Seeley RJ. Combined blockade of both micro - and kappa-opioid receptors prevents the acute orexigenic action of Agouti-related protein. Endocrinology. 143: 4265-70. PMID 12399421 DOI: 10.1210/En.2002-220230  0.648
2002 Benoit SC, Air EL, Coolen LM, Strauss R, Jackman A, Clegg DJ, Seeley RJ, Woods SC. The catabolic action of insulin in the brain is mediated by melanocortins. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 9048-52. PMID 12388611 DOI: 10.1523/Jneurosci.22-20-09048.2002  0.828
2002 Clegg DJ, Air EL, Woods SC, Seeley RJ. Eating elicited by orexin-a, but not melanin-concentrating hormone, is opioid mediated. Endocrinology. 143: 2995-3000. PMID 12130565 DOI: 10.1210/Endo.143.8.8977  0.804
2002 Air EL, Benoit SC, Clegg DJ, Seeley RJ, Woods SC. Insulin and leptin combine additively to reduce food intake and body weight in rats. Endocrinology. 143: 2449-52. PMID 12021212 DOI: 10.1210/Endo.143.6.8948  0.845
2002 Air EL, Benoit SC, Blake Smith KA, Clegg DJ, Woods SC. Acute third ventricular administration of insulin decreases food intake in two paradigms. Pharmacology, Biochemistry, and Behavior. 72: 423-9. PMID 11900815 DOI: 10.1016/S0091-3057(01)00780-8  0.838
1999 Clegg D, Faircloth R, Martin R, Flatt W. Dietary Effects Of The High Fat Ketogenic And High Protein Ketogenic Diets In Obese And Lean Zucker Rats Journal of the American Dietetic Association. 99: A11. DOI: 10.1016/S0002-8223(99)00440-X  0.313
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