| Year |
Citation |
Score |
| 2019 |
Cai H, Everett R, Thakker DR. Efficacious Dose of Metformin for Breast Cancer Therapy is Determined by Cation Transporter Expression in Tumors. British Journal of Pharmacology. PMID 31032880 DOI: 10.1111/Bph.14694 |
0.37 |
|
| 2019 |
Muralidharan A, Guo H, Han J, Zhang L, Sun W, Yin Y, Zhou C, Everett RS, Thakker DR, Bae-Jump VL. Abstract 3609: Metformin treatment outcomes in relation to obesity and cation transporter expression in mouse models of endometrial cancer Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-3609 |
0.309 |
|
| 2018 |
Muralidharan A, Bae-Jump VL, Thakker DR. Abstract 4916: OCT and MATE transporters mediate uptake and antiproliferative activity of the anticancer drug metformin in endometrial cancer cell lines Cancer Research. 78: 4916-4916. DOI: 10.1158/1538-7445.Am2018-4916 |
0.477 |
|
| 2018 |
Lee CM, Thakker DR. Evidence for the role of OATP and PEPT1 transporters in the intestinal apical transport of amoxicillin Drug Metabolism and Pharmacokinetics. 33: S95. DOI: 10.1016/J.Dmpk.2017.11.307 |
0.487 |
|
| 2017 |
Zane NR, Chen Y, Wang MZ, Thakker DR. Cytochrome P450 and flavin-containing monooxygenase families: Age-dependent differences in expression and functional activity. Pediatric Research. PMID 28922349 DOI: 10.1038/Pr.2017.226 |
0.318 |
|
| 2016 |
Proctor WR, Ming X, Bourdet D, Han TK, Everett RS, Thakker DR. Why Does the Intestine Lack Basolateral Efflux Transporters for Cationic Compounds? A Provocative Hypothesis. Journal of Pharmaceutical Sciences. 105: 484-96. PMID 26869413 DOI: 10.1016/J.Xphs.2015.11.040 |
0.81 |
|
| 2015 |
Cai H, Zhang Y, Han TK, Everett RS, Thakker DR. Cation-selective transporters are critical to the ampk-mediated antiproliferative effects of metformin in human breast cancer cells. International Journal of Cancer. Journal International Du Cancer. PMID 26669511 DOI: 10.1002/Ijc.29965 |
0.6 |
|
| 2015 |
Han TK, Proctor WR, Costales CL, Cai H, Everett RS, Thakker DR. Four cation-selective transporters contribute to apical uptake and accumulation of metformin in Caco-2 cell monolayers. The Journal of Pharmacology and Experimental Therapeutics. 352: 519-28. PMID 25563903 DOI: 10.1124/Jpet.114.220350 |
0.815 |
|
| 2014 |
Cai H, Wahajuddin M, Everett R, Thakker DR. Abstract 4639: Do cation-selective transporters help or hurt the antitumor efficacy of metformin in breast cancer Cancer Research. 74: 4639-4639. DOI: 10.1158/1538-7445.Am2014-4639 |
0.377 |
|
| 2014 |
Alluri RV, Ward P, Kunta JR, Ferslew BC, Thakker DR, Dallas S. In vitro characterization of intestinal and hepatic transporters: MRP2 Methods in Pharmacology and Toxicology. 369-404. DOI: 10.1007/978-1-62703-742-6-22 |
0.347 |
|
| 2013 |
Dufek MB, Bridges AS, Thakker DR. Intestinal first-pass metabolism by cytochrome p450 and not p-glycoprotein is the major barrier to amprenavir absorption. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1695-702. PMID 23821186 DOI: 10.1124/Dmd.113.052191 |
0.396 |
|
| 2013 |
Han TK, Everett RS, Proctor WR, Ng CM, Costales CL, Brouwer KL, Thakker DR. Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes. Molecular Pharmacology. 84: 182-9. PMID 23680637 DOI: 10.1124/Mol.112.084517 |
0.793 |
|
| 2013 |
Swift B, Nebot N, Lee JK, Han T, Proctor WR, Thakker DR, Lang D, Radtke M, Gnoth MJ, Brouwer KL. Sorafenib hepatobiliary disposition: mechanisms of hepatic uptake and disposition of generated metabolites. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1179-86. PMID 23482500 DOI: 10.1124/Dmd.112.048181 |
0.629 |
|
| 2013 |
Dufek MB, Knight BM, Bridges AS, Thakker DR. P-glycoprotein increases portal bioavailability of loperamide in mouse by reducing first-pass intestinal metabolism. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 642-50. PMID 23288866 DOI: 10.1124/Dmd.112.049965 |
0.747 |
|
| 2013 |
Generaux CN, Ainslie GR, Bridges AS, Ismail MA, Boykin DW, Tidwell RR, Thakker DR, Paine MF. Compartmental and enzyme kinetic modeling to elucidate the biotransformation pathway of a centrally acting antitrypanosomal prodrug. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 518-28. PMID 23223498 DOI: 10.1124/Dmd.112.048231 |
0.73 |
|
| 2013 |
Everett RS, Zhang Y, Ononiwu IM, Bae-Jump VL, Thakker DR. Abstract 4427: Multiple cation-selective transporters contribute to the anti-proliferative effects of metformin in ovarian cancer cell lines. Cancer Research. 73: 4427-4427. DOI: 10.1158/1538-7445.Am2013-4427 |
0.435 |
|
| 2013 |
Damery E, Zhang Y, Everett R, Bae-Jump V, Thakker D. Cation-selective transporters are critical to the anticancer efficacy of metformin in endometrial cancer Gynecologic Oncology. 130: e90-e91. DOI: 10.1016/J.Ygyno.2013.04.270 |
0.383 |
|
| 2012 |
Zhang Y, Everett RS, Thakker DR. Abstract LB-345: Differences in metformin transporter expression between breast tumor and breast cancer cell lines: selecting a relevant breast cancer cell model for metformin therapy Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-345 |
0.346 |
|
| 2011 |
Ming X, Knight BM, Thakker DR. Vectorial transport of fexofenadine across Caco-2 cells: involvement of apical uptake and basolateral efflux transporters. Molecular Pharmaceutics. 8: 1677-86. PMID 21780830 DOI: 10.1021/Mp200026V |
0.824 |
|
| 2011 |
Yanni SB, Smith PB, Benjamin DK, Augustijns PF, Thakker DR, Annaert PP. Higher clearance of micafungin in neonates compared with adults: role of age-dependent micafungin serum binding. Biopharmaceutics & Drug Disposition. 32: 222-32. PMID 21449041 DOI: 10.1002/Bdd.752 |
0.33 |
|
| 2011 |
Klein RR, Bourdon DM, Costales CL, Wagner CD, White WL, Williams JD, Hicks SN, Sondek J, Thakker DR. Direct activation of human phospholipase C by its well known inhibitor u73122. The Journal of Biological Chemistry. 286: 12407-16. PMID 21266572 DOI: 10.1074/Jbc.M110.191783 |
0.752 |
|
| 2010 |
Yanni SB, Augustijns PF, Benjamin DK, Brouwer KL, Thakker DR, Annaert PP. In vitro investigation of the hepatobiliary disposition mechanisms of the antifungal agent micafungin in humans and rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 1848-56. PMID 20606004 DOI: 10.1124/Dmd.110.033811 |
0.429 |
|
| 2010 |
Ming X, Thakker DR. Role of basolateral efflux transporter MRP4 in the intestinal absorption of the antiviral drug adefovir dipivoxil. Biochemical Pharmacology. 79: 455-62. PMID 19735648 DOI: 10.1016/J.Bcp.2009.08.029 |
0.642 |
|
| 2010 |
Proctor WR, Ming X, Thakker DR. In vitro techniques to study drug-drug interactions involving transport: Caco-2 model for study of P-glycoprotein and other transporters Enzyme- and Transporter-Based Drug-Drug Interactions: Progress and Future Challenges. 257-282. DOI: 10.1007/978-1-4419-0840-7_10 |
0.588 |
|
| 2009 |
Ming X, Ju W, Wu H, Tidwell RR, Hall JE, Thakker DR. Transport of dicationic drugs pentamidine and furamidine by human organic cation transporters. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 424-30. PMID 18971316 DOI: 10.1124/Dmd.108.024083 |
0.648 |
|
| 2008 |
Proctor WR, Bourdet DL, Thakker DR. Mechanisms underlying saturable intestinal absorption of metformin. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 1650-8. PMID 18458049 DOI: 10.1124/Dmd.107.020180 |
0.771 |
|
| 2008 |
Yanni SB, Annaert PP, Augustijns P, Bridges A, Gao Y, Benjamin DK, Thakker DR. Role of flavin-containing monooxygenase in oxidative metabolism of voriconazole by human liver microsomes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 1119-25. PMID 18362161 DOI: 10.1124/Dmd.107.019646 |
0.312 |
|
| 2008 |
Tippin TK, Thakker DR. Biorelevant refinement of the Caco-2 cell culture model to assess efficacy of paracellular permeability enhancers. Journal of Pharmaceutical Sciences. 97: 1977-92. PMID 17724658 DOI: 10.1002/Jps.21118 |
0.766 |
|
| 2006 |
Knight B, Troutman M, Thakker DR. Deconvoluting the effects of P-glycoprotein on intestinal CYP3A: a major challenge. Current Opinion in Pharmacology. 6: 528-32. PMID 16899406 DOI: 10.1016/J.Coph.2006.04.009 |
0.782 |
|
| 2006 |
Bourdet DL, Pollack GM, Thakker DR. Intestinal absorptive transport of the hydrophilic cation ranitidine: a kinetic modeling approach to elucidate the role of uptake and efflux transporters and paracellular vs. transcellular transport in Caco-2 cells. Pharmaceutical Research. 23: 1178-87. PMID 16741656 DOI: 10.1007/S11095-006-0204-Y |
0.773 |
|
| 2006 |
Bourdet DL, Thakker DR. Saturable absorptive transport of the hydrophilic organic cation ranitidine in Caco-2 cells: role of pH-dependent organic cation uptake system and P-glycoprotein. Pharmaceutical Research. 23: 1165-77. PMID 16741655 DOI: 10.1007/S11095-006-0251-4 |
0.781 |
|
| 2005 |
Bourdet DL, Pritchard JB, Thakker DR. Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3). The Journal of Pharmacology and Experimental Therapeutics. 315: 1288-97. PMID 16141367 DOI: 10.1124/Jpet.105.091223 |
0.734 |
|
| 2004 |
Bourdet DL, Lee K, Thakker DR. Photoaffinity labeling of the anionic sites in Caco-2 cells mediating saturable transport of hydrophilic cations ranitidine and famotidine. Journal of Medicinal Chemistry. 47: 2935-8. PMID 15139772 DOI: 10.1021/Jm030433N |
0.788 |
|
| 2004 |
Ansede JH, Thakker DR. High-throughput screening for stability and inhibitory activity of compounds toward cytochrome P450-mediated metabolism. Journal of Pharmaceutical Sciences. 93: 239-55. PMID 14705182 DOI: 10.1002/Jps.10545 |
0.323 |
|
| 2003 |
Troutman MD, Thakker DR. Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharmaceutical Research. 20: 1210-24. PMID 12948019 DOI: 10.1023/A:1025001131513 |
0.759 |
|
| 2003 |
Troutman MD, Thakker DR. Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers. Pharmaceutical Research. 20: 1200-9. PMID 12948018 DOI: 10.1023/A:1025049014674 |
0.769 |
|
| 2003 |
Troutman MD, Thakker DR. Rhodamine 123 requires carrier-mediated influx for its activity as a P-glycoprotein substrate in Caco-2 cells. Pharmaceutical Research. 20: 1192-9. PMID 12948017 DOI: 10.1023/A:1025096930604 |
0.742 |
|
| 2002 |
Zhou L, Lee K, Thakker DR, Boykin DW, Tidwell RR, Hall JE. Enhanced permeability of the antimicrobial agent 2,5-bis(4-amidinophenyl)furan across Caco-2 cell monolayers via its methylamidoidme prodrug. Pharmaceutical Research. 19: 1689-95. PMID 12458675 DOI: 10.1023/A:1020957430400 |
0.573 |
|
| 2002 |
Lee K, Ng C, Brouwer KL, Thakker DR. Secretory transport of ranitidine and famotidine across Caco-2 cell monolayers. The Journal of Pharmacology and Experimental Therapeutics. 303: 574-80. PMID 12388638 DOI: 10.1124/Jpet.102.038521 |
0.743 |
|
| 2002 |
Ward PD, Klein RR, Troutman MD, Desai S, Thakker DR. Phospholipase C-gamma modulates epithelial tight junction permeability through hyperphosphorylation of tight junction proteins. The Journal of Biological Chemistry. 277: 35760-5. PMID 12101180 DOI: 10.1074/Jbc.M203134200 |
0.753 |
|
| 2002 |
Ouyang H, Morris-Natschke SL, Ishaq KS, Ward P, Liu D, Leonard S, Thakker DR. Structure-activity relationship for enhancement of paracellular permeability across Caco-2 cell monolayers by 3-alkylamido-2-alkoxypropylphosphocholines. Journal of Medicinal Chemistry. 45: 2857-66. PMID 12061888 DOI: 10.1021/Jm020001X |
0.343 |
|
| 2000 |
Ward PD, Tippin TK, Thakker DR. Enhancing paracellular permeability by modulating epithelial tight junctions. Pharmaceutical Science & Technology Today. 3: 346-358. PMID 11050459 DOI: 10.1016/S1461-5347(00)00302-3 |
0.767 |
|
| 1999 |
Liu DZ, Morris-Natschke SL, Kucera LS, Ishaq KS, Thakker DR. Structure-activity relationships for enhancement of paracellular permeability by 2-alkoxy-3-alkylamidopropylphosphocholines across Caco-2 cell monolayers. Journal of Pharmaceutical Sciences. 88: 1169-74. PMID 10564066 DOI: 10.1021/Js9900957 |
0.387 |
|
| 1999 |
Liu DZ, LeCluyse EL, Thakker DR. Dodecylphosphocholine-mediated enhancement of paracellular permeability and cytotoxicity in Caco-2 cell monolayers. Journal of Pharmaceutical Sciences. 88: 1161-8. PMID 10564065 DOI: 10.1021/Js990094E |
0.441 |
|
| 1999 |
Lee K, Thakker DR. Saturable transport of H2-antagonists ranitidine and famotidine across Caco-2 cell monolayers. Journal of Pharmaceutical Sciences. 88: 680-7. PMID 10393565 DOI: 10.1021/Js980474K |
0.635 |
|
| 1998 |
Gan LS, Yanni S, Thakker DR. Modulation of the tight junctions of the Caco-2 cell monolayers by H2-antagonists. Pharmaceutical Research. 15: 53-7. PMID 9487546 DOI: 10.1023/A:1011944602662 |
0.317 |
|
| 1997 |
Gan LSL, Thakker DR. Applications of the Caco-2 model in the design and development of orally active drugs: Elucidation of biochemical and physical barriers posed by the intestinal epithelium Advanced Drug Delivery Reviews. 23: 77-98. DOI: 10.1016/S0169-409X(96)00427-9 |
0.387 |
|
| 1996 |
Gan LS, Moseley MA, Khosla B, Augustijns PF, Bradshaw TP, Hendren RW, Thakker DR. CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 24: 344-9. PMID 8820426 |
0.406 |
|
| 1994 |
Gan LS, Eads C, Niederer T, Bridgers A, Yanni S, Hsyu PH, Pritchard FJ, Thakker D. Use of CACO-2 cells as an in vitro intestinal absorption and metabolism model Drug Development and Industrial Pharmacy. 20: 615-631. DOI: 10.3109/03639049409038322 |
0.451 |
|
| 1993 |
Gan LS, Hsyu PH, Pritchard JF, Thakker D. Mechanism of intestinal absorption of ranitidine and ondansetron: transport across Caco-2 cell monolayers. Pharmaceutical Research. 10: 1722-5. PMID 8302757 DOI: 10.1023/A:1018965929419 |
0.49 |
|
| 1993 |
Gan LS, Niederer T, Eads C, Thakker D. Evidence for predominantly paracellular transport of thyrotropin-releasing hormone across CACO-2 cell monolayers. Biochemical and Biophysical Research Communications. 197: 771-7. PMID 8267614 DOI: 10.1006/Bbrc.1993.2545 |
0.413 |
|
| 1993 |
Augustijns PF, Bradshaw TP, Gan LS, Hendren RW, Thakker DR. Evidence for a polarized efflux system in CACO-2 cells capable of modulating cyclosporin A transport. Biochemical and Biophysical Research Communications. 197: 360-5. PMID 7903526 DOI: 10.1006/Bbrc.1993.2487 |
0.51 |
|
| 1983 |
Ittah Y, Thakker DR, Levin W, Croisy-Delcey M, Ryan DE, Thomas PE, Conney AH, Jerina DM. Metabolism of benzo[c]phenanthrene by rat liver microsomes and by a purified monooxygenase system reconstituted with different isozymes of cytochrome P-450. Chemico-Biological Interactions. 45: 15-28. PMID 6872097 DOI: 10.1016/0009-2797(83)90039-X |
0.303 |
|
| Show low-probability matches. |