| Year |
Citation |
Score |
| 2020 |
Cunnane SC, Trushina E, Morland C, Prigione A, Casadesus G, Andrews ZB, Beal MF, Bergersen LH, Brinton RD, de la Monte S, Eckert A, Harvey J, Jeggo R, Jhamandas JH, Kann O, et al. Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing. Nature Reviews. Drug Discovery. PMID 32709961 DOI: 10.1038/S41573-020-0072-X |
0.336 |
|
| 2020 |
Fourcade S, Goicoechea L, Parameswaran J, Schlüter A, Launay N, Ruiz M, Seyer A, Colsch B, Calingasan NY, Ferrer I, Beal MF, Sedel F, Pujol A. High-dose biotin restores redox balance, energy and lipid homeostasis, and axonal health in a model of adrenoleukodystrophy. Brain Pathology (Zurich, Switzerland). PMID 32511826 DOI: 10.1111/Bpa.12869 |
0.313 |
|
| 2020 |
Cristóvão AC, Campos FL, Je G, Esteves M, Guhathakurta S, Yang L, Beal MF, Fonseca BM, Salgado AJ, Queiroz J, Sousa N, Bernardino L, Alves G, Yoon KS, Kim YS. Characterization of a Parkinson's disease rat model using an upgraded paraquat exposure paradigm. The European Journal of Neuroscience. PMID 31958881 DOI: 10.1111/Ejn.14683 |
0.664 |
|
| 2019 |
Lloret A, Beal MF. PGC-1α, Sirtuins and PARPs in Huntington's Disease and Other Neurodegenerative Conditions: NAD+ to Rule Them All. Neurochemical Research. PMID 31065944 DOI: 10.1007/S11064-019-02809-1 |
0.379 |
|
| 2019 |
Shchepinov MS, Beal MF, Brenna JT, Calingasan NY, Chiluwal J, Korneenko TV, Lee M, Liu L, Milne GL, Pestov NB, Tapias V, Vijg J. Beneficial Effect of Deuterated Polyunsaturated Fatty Acids in Rodent Models of Parkinson's Disease and Aging European Journal of Lipid Science and Technology. 1800469. DOI: 10.1002/Ejlt.201800469 |
0.331 |
|
| 2018 |
Bose A, Beal MF. Mitochondrial dysfunction and oxidative stress in induced pluripotent stem cell models of Parkinson's disease. The European Journal of Neuroscience. PMID 30408242 DOI: 10.1111/Ejn.14264 |
0.395 |
|
| 2018 |
Ranea-Robles P, Launay N, Ruiz M, Calingasan NY, Dumont M, Naudí A, Portero-Otín M, Pamplona R, Ferrer I, Beal MF, Fourcade S, Pujol A. Aberrant regulation of the GSK-3β/NRF2 axis unveils a novel therapy for adrenoleukodystrophy. Embo Molecular Medicine. PMID 29997171 DOI: 10.15252/Emmm.201708604 |
0.542 |
|
| 2018 |
Tapias V, Jainuddin S, Ahuja M, Stack C, Elipenahli C, Vignisse J, Gerges M, Starkova N, Xu H, Starkov AA, Bettendorff L, Hushpulian DM, Smirnova NA, Gazaryan IG, Kaidery NA, ... ... Beal MF, et al. Benfotiamine Treatment Activates the Nrf2/ARE Pathway and is Neuroprotective in a Transgenic Mouse Model of Tauopathy. Human Molecular Genetics. PMID 29860433 DOI: 10.1093/Hmg/Ddy201 |
0.643 |
|
| 2018 |
Chen Q, Kirk K, Shurubor YI, Zhao D, Arreguin AJ, Shahi I, Valsecchi F, Primiano G, Calder EL, Carelli V, Denton TT, Beal MF, Gross SS, Manfredi G, D'Aurelio M. Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations. Cell Metabolism. PMID 29657030 DOI: 10.1016/J.Cmet.2018.03.002 |
0.359 |
|
| 2016 |
Chen H, Denton TT, Xu H, Calingasan N, Beal MF, Gibson GE. Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental? Journal of Neurochemistry. PMID 27580471 DOI: 10.1111/Jnc.13836 |
0.381 |
|
| 2016 |
Bose A, Beal MF. Mitochondrial dysfunction in Parkinson's disease. Journal of Neurochemistry. PMID 27546335 DOI: 10.1111/Jnc.13731 |
0.373 |
|
| 2016 |
Ahuja M, Ammal Kaidery N, Yang L, Calingasan N, Smirnova N, Gaisin A, Gaisina IN, Gazaryan I, Hushpulian DM, Kaddour-Djebbar I, Bollag WB, Morgan JC, Ratan RR, Starkov AA, Beal MF, et al. Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 6332-51. PMID 27277809 DOI: 10.1523/Jneurosci.0426-16.2016 |
0.723 |
|
| 2016 |
Chandra A, Sharma A, Calingasan NY, White JM, Shurubor Y, Yang XW, Beal MF, Johri A. Enhanced Mitochondrial Biogenesis Ameliorates Disease Phenotype in a Full-Length Mouse Model of Huntington's Disease. Human Molecular Genetics. PMID 27008868 DOI: 10.1093/Hmg/Ddw095 |
0.622 |
|
| 2015 |
Esmaeili MA, Yadav S, Gupta RK, Waggoner GR, DeLoach A, Calingasan NY, Beal MF, Kiaei M. Preferential PPAR-alpha activation reduces neuroinflammation, and blocks neurodegeneration in vivo. Human Molecular Genetics. PMID 26604138 DOI: 10.1093/Hmg/Ddv477 |
0.416 |
|
| 2015 |
Clark-Matott J, Saleem A, Dai Y, Shurubor Y, Ma X, Safdar A, Beal MF, Tarnopolsky M, Simon DK. Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain. Neurobiology of Aging. 36: 2972-83. PMID 26294258 DOI: 10.1016/J.Neurobiolaging.2015.07.020 |
0.473 |
|
| 2015 |
Weiduschat N, Mao X, Beal MF, Nirenberg MJ, Shungu DC, Henchcliffe C. Usefulness of proton and phosphorus MR spectroscopic imaging for early diagnosis of Parkinson's disease. Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging. 25: 105-10. PMID 24325203 DOI: 10.1111/Jon.12074 |
0.334 |
|
| 2014 |
Boussicault L, Hérard AS, Calingasan N, Petit F, Malgorn C, Merienne N, Jan C, Gaillard MC, Lerchundi R, Barros LF, Escartin C, Delzescaux T, Mariani J, Hantraye P, Beal MF, et al. Impaired brain energy metabolism in the BACHD mouse model of Huntington's disease: critical role of astrocyte-neuron interactions. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 34: 1500-10. PMID 24938402 DOI: 10.1038/Jcbfm.2014.110 |
0.628 |
|
| 2014 |
Beal MF, Oakes D, Shoulson I, Henchcliffe C, Galpern WR, Haas R, Juncos JL, Nutt JG, Voss TS, Ravina B, Shults CM, Helles K, Snively V, Lew MF, et al. A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit. Jama Neurology. 71: 543-52. PMID 24664227 DOI: 10.1001/Jamaneurol.2014.131 |
0.486 |
|
| 2014 |
Weiduschat N, Mao X, Beal MF, Nirenberg MJ, Shungu DC, Henchcliffe C. Sex differences in cerebral energy metabolism in Parkinson's disease: a phosphorus magnetic resonance spectroscopic imaging study. Parkinsonism & Related Disorders. 20: 545-8. PMID 24593902 DOI: 10.1016/J.Parkreldis.2014.02.003 |
0.31 |
|
| 2014 |
Chandra A, Johri A, Beal MF. Prospects for neuroprotective therapies in prodromal Huntington's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 29: 285-93. PMID 24573776 DOI: 10.1002/Mds.25835 |
0.59 |
|
| 2014 |
Stack C, Jainuddin S, Elipenahli C, Gerges M, Starkova N, Starkov AA, Jové M, Portero-Otin M, Launay N, Pujol A, Kaidery NA, Thomas B, Tampellini D, Beal MF, Dumont M. Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity. Human Molecular Genetics. 23: 3716-32. PMID 24556215 DOI: 10.1093/Hmg/Ddu080 |
0.665 |
|
| 2014 |
Dumont M, Stack C, Elipenahli C, Jainuddin S, Launay N, Gerges M, Starkova N, Starkov AA, Calingasan NY, Tampellini D, Pujol A, Beal MF. PGC-1α overexpression exacerbates β-amyloid and tau deposition in a transgenic mouse model of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 1745-55. PMID 24398293 DOI: 10.1096/Fj.13-236331 |
0.594 |
|
| 2013 |
Inoue K, Rispoli J, Yang L, Macleod D, Beal MF, Klann E, Abeliovich A. Coordinate regulation of mature dopaminergic axon morphology by macroautophagy and the PTEN signaling pathway. Plos Genetics. 9: e1003845. PMID 24098148 DOI: 10.1371/Journal.Pgen.1003845 |
0.582 |
|
| 2013 |
Morató L, Galino J, Ruiz M, Calingasan NY, Starkov AA, Dumont M, Naudà A, MartÃnez JJ, Aubourg P, Portero-OtÃn M, Pamplona R, Galea E, Beal MF, Ferrer I, Fourcade S, et al. Pioglitazone halts axonal degeneration in a mouse model of X-linked adrenoleukodystrophy. Brain : a Journal of Neurology. 136: 2432-43. PMID 23794606 DOI: 10.1093/Brain/Awt143 |
0.556 |
|
| 2013 |
Damiano M, Diguet E, Malgorn C, D'Aurelio M, Galvan L, Petit F, Benhaim L, Guillermier M, Houitte D, Dufour N, Hantraye P, Canals JM, Alberch J, Delzescaux T, Déglon N, ... Beal MF, et al. A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin. Human Molecular Genetics. 22: 3869-82. PMID 23720495 DOI: 10.1093/Hmg/Ddt242 |
0.743 |
|
| 2013 |
Johri A, Chandra A, Beal MF. PGC-1α, mitochondrial dysfunction, and Huntington's disease. Free Radical Biology & Medicine. 62: 37-46. PMID 23602910 DOI: 10.1016/J.Freeradbiomed.2013.04.016 |
0.591 |
|
| 2013 |
Franco MC, Ye Y, Refakis CA, Feldman JL, Stokes AL, Basso M, Melero Fernández de Mera RM, Sparrow NA, Calingasan NY, Kiaei M, Rhoads TW, Ma TC, Grumet M, Barnes S, Beal MF, et al. Nitration of Hsp90 induces cell death. Proceedings of the National Academy of Sciences of the United States of America. 110: E1102-11. PMID 23487751 DOI: 10.1073/Pnas.1215177110 |
0.342 |
|
| 2013 |
Kiss G, Konrad C, Doczi J, Starkov AA, Kawamata H, Manfredi G, Zhang SF, Gibson GE, Beal MF, Adam-Vizi V, Chinopoulos C. The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 2392-406. PMID 23475850 DOI: 10.1096/Fj.12-220202 |
0.356 |
|
| 2013 |
Chaturvedi RK, Beal MF. Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases. Molecular and Cellular Neurosciences. 55: 101-14. PMID 23220289 DOI: 10.1016/J.Mcn.2012.11.011 |
0.558 |
|
| 2013 |
Kaidery NA, Banerjee R, Yang L, Smirnova NA, Hushpulian DM, Liby KT, Williams CR, Yamamoto M, Kensler TW, Ratan RR, Sporn MB, Beal MF, Gazaryan IG, Thomas B. Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease. Antioxidants & Redox Signaling. 18: 139-57. PMID 22746536 DOI: 10.1089/Ars.2011.4491 |
0.707 |
|
| 2012 |
Yao J, Ho D, Calingasan NY, Pipalia NH, Lin MT, Beal MF. Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease. The Journal of Experimental Medicine. 209: 2501-13. PMID 23209315 DOI: 10.1084/Jem.20121239 |
0.562 |
|
| 2012 |
Dumont M, Stack C, Elipenahli C, Jainuddin S, Gerges M, Starkova N, Calingasan NY, Yang L, Tampellini D, Starkov AA, Chan RB, Di Paolo G, Pujol A, Beal MF. Bezafibrate administration improves behavioral deficits and tau pathology in P301S mice. Human Molecular Genetics. 21: 5091-105. PMID 22922230 DOI: 10.1093/Hmg/Dds355 |
0.712 |
|
| 2012 |
Lin MT, Cantuti-Castelvetri I, Zheng K, Jackson KE, Tan YB, Arzberger T, Lees AJ, Betensky RA, Beal MF, Simon DK. Somatic mitochondrial DNA mutations in early Parkinson and incidental Lewy body disease. Annals of Neurology. 71: 850-4. PMID 22718549 DOI: 10.1002/Ana.23568 |
0.627 |
|
| 2012 |
Johri A, Beal MF. Mitochondrial dysfunction in neurodegenerative diseases. The Journal of Pharmacology and Experimental Therapeutics. 342: 619-30. PMID 22700435 DOI: 10.1124/Jpet.112.192138 |
0.616 |
|
| 2012 |
Chaturvedi RK, Hennessey T, Johri A, Tiwari SK, Mishra D, Agarwal S, Kim YS, Beal MF. Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington's disease. Human Molecular Genetics. 21: 3474-88. PMID 22589249 DOI: 10.1093/Hmg/Dds178 |
0.714 |
|
| 2012 |
Gollamudi S, Johri A, Calingasan NY, Yang L, Elemento O, Beal MF. Concordant signaling pathways produced by pesticide exposure in mice correspond to pathways identified in human Parkinson's disease. Plos One. 7: e36191. PMID 22563483 DOI: 10.1371/Journal.Pone.0036191 |
0.679 |
|
| 2012 |
Johri A, Beal MF. Muscling in on PGC-1α for improved quality of life in ALS. Cell Metabolism. 15: 567-9. PMID 22560208 DOI: 10.1016/J.Cmet.2012.04.015 |
0.524 |
|
| 2012 |
Islam R, Yang L, Sah M, Kannan K, Anamani D, Vijayan C, Kwok J, Cantino ME, Beal MF, Fridell YW. A neuroprotective role of the human uncoupling protein 2 (hUCP2) in a Drosophila Parkinson's disease model. Neurobiology of Disease. 46: 137-46. PMID 22266335 DOI: 10.1016/J.Nbd.2011.12.055 |
0.662 |
|
| 2012 |
Johri A, Beal MF. Antioxidants in Huntington's disease. Biochimica Et Biophysica Acta. 1822: 664-74. PMID 22138129 DOI: 10.1016/J.Bbadis.2011.11.014 |
0.634 |
|
| 2012 |
Choi DH, Cristóvão AC, Guhathakurta S, Lee J, Joh TH, Beal MF, Kim YS. NADPH oxidase 1-mediated oxidative stress leads to dopamine neuron death in Parkinson's disease. Antioxidants & Redox Signaling. 16: 1033-45. PMID 22098189 DOI: 10.1089/Ars.2011.3960 |
0.512 |
|
| 2012 |
Johri A, Calingasan NY, Hennessey TM, Sharma A, Yang L, Wille E, Chandra A, Beal MF. Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease. Human Molecular Genetics. 21: 1124-37. PMID 22095692 DOI: 10.1093/Hmg/Ddr541 |
0.747 |
|
| 2012 |
Elipenahli C, Stack C, Jainuddin S, Gerges M, Yang L, Starkov A, Beal MF, Dumont M. Behavioral improvement after chronic administration of coenzyme Q10 in P301S transgenic mice. Journal of Alzheimer's Disease : Jad. 28: 173-82. PMID 21971408 DOI: 10.3233/Jad-2011-111190 |
0.704 |
|
| 2012 |
Thomas B, Banerjee R, Starkova NN, Zhang SF, Calingasan NY, Yang L, Wille E, Lorenzo BJ, Ho DJ, Beal MF, Starkov A. Mitochondrial permeability transition pore component cyclophilin D distinguishes nigrostriatal dopaminergic death paradigms in the MPTP mouse model of Parkinson's disease. Antioxidants & Redox Signaling. 16: 855-68. PMID 21529244 DOI: 10.1089/Ars.2010.3849 |
0.734 |
|
| 2012 |
Lin MT, Cantuti-Castelvetri I, Lees AJ, Beal MF, Simon DK. Reply Annals of Neurology. 72: 823-824. DOI: 10.1002/ana.23739 |
0.308 |
|
| 2011 |
Kriks S, Shim JW, Piao J, Ganat YM, Wakeman DR, Xie Z, Carrillo-Reid L, Auyeung G, Antonacci C, Buch A, Yang L, Beal MF, Surmeier DJ, Kordower JH, Tabar V, et al. Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease. Nature. 480: 547-51. PMID 22056989 DOI: 10.1038/Nature10648 |
0.637 |
|
| 2011 |
Henchcliffe C, Dodel R, Beal MF. Biomarkers of Parkinson's disease and Dementia with Lewy bodies. Progress in Neurobiology. 95: 601-13. PMID 21983334 DOI: 10.1016/J.Pneurobio.2011.09.002 |
0.315 |
|
| 2011 |
Yang L, Beal MF. Determination of neurotransmitter levels in models of Parkinson's disease by HPLC-ECD. Methods in Molecular Biology (Clifton, N.J.). 793: 401-15. PMID 21913116 DOI: 10.1007/978-1-61779-328-8_27 |
0.612 |
|
| 2011 |
Dumont M, Kipiani K, Yu F, Wille E, Katz M, Calingasan NY, Gouras GK, Lin MT, Beal MF. Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 27: 211-23. PMID 21799249 DOI: 10.3233/Jad-2011-110209 |
0.817 |
|
| 2011 |
Johri A, Starkov AA, Chandra A, Hennessey T, Sharma A, Orobello S, Squitieri F, Yang L, Beal MF. Truncated peroxisome proliferator-activated receptor-γ coactivator 1α splice variant is severely altered in Huntington's disease. Neuro-Degenerative Diseases. 8: 496-503. PMID 21757867 DOI: 10.1159/000327910 |
0.719 |
|
| 2011 |
Thomas B, Beal MF. Molecular insights into Parkinson's disease. F1000 Medicine Reports. 3: 7. PMID 21655332 DOI: 10.3410/M3-7 |
0.546 |
|
| 2011 |
Ramonet D, Daher JP, Lin BM, Stafa K, Kim J, Banerjee R, Westerlund M, Pletnikova O, Glauser L, Yang L, Liu Y, Swing DA, Beal MF, Troncoso JC, McCaffery JM, et al. Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. Plos One. 6: e18568. PMID 21494637 DOI: 10.1371/Journal.Pone.0018568 |
0.712 |
|
| 2011 |
Neymotin A, Calingasan NY, Wille E, Naseri N, Petri S, Damiano M, Liby KT, Risingsong R, Sporn M, Beal MF, Kiaei M. Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis. Free Radical Biology & Medicine. 51: 88-96. PMID 21457778 DOI: 10.1016/J.Freeradbiomed.2011.03.027 |
0.726 |
|
| 2011 |
Beal MF. Neuroprotective effects of creatine. Amino Acids. 40: 1305-13. PMID 21448659 DOI: 10.1007/S00726-011-0851-0 |
0.463 |
|
| 2011 |
Johri A, Chaturvedi RK, Beal MF. Hugging tight in Huntington's. Nature Medicine. 17: 245-6. PMID 21383715 DOI: 10.1038/Nm0311-245 |
0.677 |
|
| 2011 |
Choi DH, Kim YJ, Kim YG, Joh TH, Beal MF, Kim YS. Role of matrix metalloproteinase 3-mediated alpha-synuclein cleavage in dopaminergic cell death. The Journal of Biological Chemistry. 286: 14168-77. PMID 21330369 DOI: 10.1074/Jbc.M111.222430 |
0.425 |
|
| 2011 |
Dumont M, Stack C, Elipenhali C, Calingasan NY, Wille E, Beal MF. Apocynin administration does not improve behavioral and neuropathological deficits in a transgenic mouse model of Alzheimer's disease. Neuroscience Letters. 492: 150-4. PMID 21300136 DOI: 10.1016/J.Neulet.2011.01.077 |
0.566 |
|
| 2011 |
Dumont M, Beal MF. Neuroprotective strategies involving ROS in Alzheimer disease. Free Radical Biology & Medicine. 51: 1014-26. PMID 21130159 DOI: 10.1016/J.Freeradbiomed.2010.11.026 |
0.559 |
|
| 2011 |
Zhang SF, Hennessey T, Yang L, Starkova NN, Beal MF, Starkov AA. Impaired brain creatine kinase activity in Huntington's disease. Neuro-Degenerative Diseases. 8: 194-201. PMID 21124007 DOI: 10.1159/000321681 |
0.594 |
|
| 2011 |
Choi DH, Hwang O, Lee KH, Lee J, Beal MF, Kim YS. DJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell death. Antioxidants & Redox Signaling. 14: 2137-50. PMID 20969476 DOI: 10.1089/Ars.2009.3059 |
0.479 |
|
| 2011 |
Godau J, Lindig T, Schöls L, Berg D, Synofzik M, Frederiksen KS, Garde E, Skimminge A, Ryberg C, Rostrup E, Baaré WFC, Siebner HR, Hejl A, Leffers A, Fiedorowicz JG, ... ... Beal MF, et al. Contents Vol. 8, 2011 Neurodegenerative Diseases. 8. DOI: 10.1159/000330927 |
0.637 |
|
| 2011 |
Johri A, Chaturvedi RK, Beal MF. Erratum: Corrigendum: Hugging tight in Huntington's Nature Medicine. 17: 514-514. DOI: 10.1038/Nm0411-514C |
0.613 |
|
| 2011 |
Johri A, Chaturvedi RK, Beal MF. Erratum: Hugging tight in Huntington's Nature Medicine. 17: 514-514. DOI: 10.1038/Nm0411-514B |
0.582 |
|
| 2010 |
Yao J, Hennessey T, Flynt A, Lai E, Beal MF, Lin MT. MicroRNA-related cofilin abnormality in Alzheimer's disease. Plos One. 5: e15546. PMID 21179570 DOI: 10.1371/Journal.Pone.0015546 |
0.561 |
|
| 2010 |
Banerjee R, Beal MF, Thomas B. Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications. Trends in Neurosciences. 33: 541-9. PMID 20947179 DOI: 10.1016/J.Tins.2010.09.001 |
0.541 |
|
| 2010 |
Beal MF. Parkinson's disease: a model dilemma. Nature. 466: S8-10. PMID 20739935 DOI: 10.1038/466S8A |
0.335 |
|
| 2010 |
Johri A, Beal MF. Hunting-ton for new proteases: MMPs as the new target? Neuron. 67: 171-3. PMID 20670824 DOI: 10.1016/J.Neuron.2010.07.011 |
0.557 |
|
| 2010 |
Hyson HC, Kieburtz K, Shoulson I, McDermott M, Ravina B, de Blieck EA, Cudkowicz ME, Ferrante RJ, Como P, Frank S, Zimmerman C, Cudkowicz ME, Ferrante K, Newhall K, ... ... Beal MF, et al. Safety and tolerability of high-dosage coenzyme Q10 in Huntington's disease and healthy subjects. Movement Disorders : Official Journal of the Movement Disorder Society. 25: 1924-8. PMID 20669312 DOI: 10.1002/mds.22408 |
0.394 |
|
| 2010 |
Yin F, Dumont M, Banerjee R, Ma Y, Li H, Lin MT, Beal MF, Nathan C, Thomas B, Ding A. Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 4639-47. PMID 20667979 DOI: 10.1096/fj.10.161471 |
0.7 |
|
| 2010 |
McConoughey SJ, Basso M, Niatsetskaya ZV, Sleiman SF, Smirnova NA, Langley BC, Mahishi L, Cooper AJ, Antonyak MA, Cerione RA, Li B, Starkov A, Chaturvedi RK, Beal MF, Coppola G, et al. Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease. Embo Molecular Medicine. 2: 349-70. PMID 20665636 DOI: 10.1002/Emmm.201000084 |
0.563 |
|
| 2010 |
Kim J, Moody JP, Edgerly CK, Bordiuk OL, Cormier K, Smith K, Beal MF, Ferrante RJ. Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease. Human Molecular Genetics. 19: 3919-35. PMID 20660112 DOI: 10.1093/Hmg/Ddq306 |
0.382 |
|
| 2010 |
Ho DJ, Calingasan NY, Wille E, Dumont M, Beal MF. Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease. Experimental Neurology. 225: 74-84. PMID 20561979 DOI: 10.1016/J.Expneurol.2010.05.006 |
0.556 |
|
| 2010 |
Chaturvedi RK, Calingasan NY, Yang L, Hennessey T, Johri A, Beal MF. Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation. Human Molecular Genetics. 19: 3190-205. PMID 20529956 DOI: 10.1093/Hmg/Ddq229 |
0.767 |
|
| 2010 |
Dumont M, Lin MT, Beal MF. Mitochondria and antioxidant targeted therapeutic strategies for Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 20: S633-43. PMID 20421689 DOI: 10.3233/Jad-2010-100507 |
0.653 |
|
| 2010 |
Stack C, Ho D, Wille E, Calingasan NY, Williams C, Liby K, Sporn M, Dumont M, Beal MF. Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease. Free Radical Biology & Medicine. 49: 147-58. PMID 20338236 DOI: 10.1016/J.Freeradbiomed.2010.03.017 |
0.586 |
|
| 2010 |
Thomas B, Beal MF. Mitochondrial therapies for Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 25: S155-60. PMID 20187246 DOI: 10.1002/Mds.22781 |
0.546 |
|
| 2010 |
Yin F, Banerjee R, Thomas B, Zhou P, Qian L, Jia T, Ma X, Ma Y, Iadecola C, Beal MF, Nathan C, Ding A. Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. The Journal of Experimental Medicine. 207: 117-28. PMID 20026663 DOI: 10.1084/Jem.20091568 |
0.538 |
|
| 2010 |
Cleren C, Calingasan NY, Starkov A, Jacquard C, Chen J, Brouillet E, Beal MF. Promethazine protects against 3-nitropropionic acid-induced neurotoxicity. Neurochemistry International. 56: 208-12. PMID 19852992 DOI: 10.1016/J.Neuint.2009.10.006 |
0.623 |
|
| 2010 |
Gibson GE, Starkov A, Blass JP, Ratan RR, Beal MF. Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases. Biochimica Et Biophysica Acta. 1802: 122-34. PMID 19715758 DOI: 10.1016/J.Bbadis.2009.08.010 |
0.399 |
|
| 2010 |
Zhu X, Beal MF, Wang X, Perry G, Smith MA. Preface: Mitochondria and neurodegenerative diseases Journal of Alzheimer's Disease. 20: S253. DOI: 10.3233/Jad-2010-1424 |
0.543 |
|
| 2009 |
Beal MF. Therapeutic approaches to mitochondrial dysfunction in Parkinson's disease. Parkinsonism & Related Disorders. 15: S189-94. PMID 20082988 DOI: 10.1016/S1353-8020(09)70812-0 |
0.402 |
|
| 2009 |
Andres-Mateos E, Mejias R, Sasaki M, Li X, Lin BM, Biskup S, Zhang L, Banerjee R, Thomas B, Yang L, Liu G, Beal MF, Huso DL, Dawson TM, Dawson VL. Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 15846-50. PMID 20016100 DOI: 10.1523/Jneurosci.4357-09.2009 |
0.711 |
|
| 2009 |
Spindler M, Beal MF, Henchcliffe C. Coenzyme Q10 effects in neurodegenerative disease. Neuropsychiatric Disease and Treatment. 5: 597-610. PMID 19966907 DOI: 10.2147/Ndt.S5212 |
0.407 |
|
| 2009 |
Neymotin A, Petri S, Calingasan NY, Wille E, Schafer P, Stewart C, Hensley K, Beal MF, Kiaei M. Lenalidomide (Revlimid) administration at symptom onset is neuroprotective in a mouse model of amyotrophic lateral sclerosis. Experimental Neurology. 220: 191-7. PMID 19733563 DOI: 10.1016/J.Expneurol.2009.08.028 |
0.561 |
|
| 2009 |
Faust K, Gehrke S, Yang Y, Yang L, Beal MF, Lu B. Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease. Bmc Neuroscience. 10: 109. PMID 19723328 DOI: 10.1186/1471-2202-10-109 |
0.638 |
|
| 2009 |
Lee DW, Rajagopalan S, Siddiq A, Gwiazda R, Yang L, Beal MF, Ratan RR, Andersen JK. Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease. The Journal of Biological Chemistry. 284: 29065-76. PMID 19679656 DOI: 10.1074/Jbc.M109.000638 |
0.637 |
|
| 2009 |
Yang L, Shi Q, Ho DJ, Starkov AA, Wille EJ, Xu H, Chen HL, Zhang S, Stack CM, Calingasan NY, Gibson GE, Beal MF. Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins. Neurobiology of Disease. 36: 320-30. PMID 19660549 DOI: 10.1016/J.Nbd.2009.07.023 |
0.681 |
|
| 2009 |
Dumont M, Ho DJ, Calingasan NY, Xu H, Gibson G, Beal MF. Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition. Free Radical Biology & Medicine. 47: 1019-27. PMID 19596066 DOI: 10.1016/J.Freeradbiomed.2009.07.008 |
0.565 |
|
| 2009 |
Li Y, Liu W, Oo TF, Wang L, Tang Y, Jackson-Lewis V, Zhou C, Geghman K, Bogdanov M, Przedborski S, Beal MF, Burke RE, Li C. Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nature Neuroscience. 12: 826-8. PMID 19503083 DOI: 10.1038/Nn.2349 |
0.403 |
|
| 2009 |
Yang L, Calingasan NY, Thomas B, Chaturvedi RK, Kiaei M, Wille EJ, Liby KT, Williams C, Royce D, Risingsong R, Musiek ES, Morrow JD, Sporn M, Beal MF. Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription. Plos One. 4: e5757. PMID 19484125 DOI: 10.1371/Journal.Pone.0005757 |
0.763 |
|
| 2009 |
Yang L, Calingasan NY, Wille EJ, Cormier K, Smith K, Ferrante RJ, Beal MF. Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases. Journal of Neurochemistry. 109: 1427-39. PMID 19476553 DOI: 10.1111/J.1471-4159.2009.06074.X |
0.69 |
|
| 2009 |
Chaturvedi RK, Adhihetty P, Shukla S, Hennessy T, Calingasan N, Yang L, Starkov A, Kiaei M, Cannella M, Sassone J, Ciammola A, Squitieri F, Beal MF. Impaired PGC-1alpha function in muscle in Huntington's disease. Human Molecular Genetics. 18: 3048-65. PMID 19460884 DOI: 10.1093/Hmg/Ddp243 |
0.791 |
|
| 2009 |
Cristóvão AC, Choi DH, Baltazar G, Beal MF, Kim YS. The role of NADPH oxidase 1-derived reactive oxygen species in paraquat-mediated dopaminergic cell death. Antioxidants & Redox Signaling. 11: 2105-18. PMID 19450058 DOI: 10.1089/Ars.2009.2459 |
0.494 |
|
| 2009 |
Dumont M, Wille E, Stack C, Calingasan NY, Beal MF, Lin MT. Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 2459-66. PMID 19346295 DOI: 10.1096/Fj.09-132928 |
0.666 |
|
| 2009 |
Liu W, Vives-Bauza C, AcÃn-Peréz- R, Yamamoto A, Tan Y, Li Y, Magrané J, Stavarache MA, Shaffer S, Chang S, Kaplitt MG, Huang XY, Beal MF, Manfredi G, Li C. PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease. Plos One. 4: e4597. PMID 19242547 DOI: 10.1371/Journal.Pone.0004597 |
0.37 |
|
| 2009 |
Yang L, Zhao K, Calingasan NY, Luo G, Szeto HH, Beal MF. Mitochondria targeted peptides protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. Antioxidants & Redox Signaling. 11: 2095-104. PMID 19203217 DOI: 10.1089/Ars.2009.2445 |
0.659 |
|
| 2009 |
Banerjee R, Starkov AA, Beal MF, Thomas B. Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis. Biochimica Et Biophysica Acta. 1792: 651-63. PMID 19059336 DOI: 10.1016/J.Bbadis.2008.11.007 |
0.554 |
|
| 2009 |
Karuppagounder SS, Pinto JT, Xu H, Chen HL, Beal MF, Gibson GE. Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease. Neurochemistry International. 54: 111-8. PMID 19041676 DOI: 10.1016/J.Neuint.2008.10.008 |
0.397 |
|
| 2009 |
Karuppagounder SS, Xu H, Shi Q, Chen LH, Pedrini S, Pechman D, Baker H, Beal MF, Gandy SE, Gibson GE. Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model. Neurobiology of Aging. 30: 1587-600. PMID 18406011 DOI: 10.1016/J.Neurobiolaging.2007.12.013 |
0.409 |
|
| 2009 |
Dumont M, Wille E, Calingasan NY, Tampellini D, Williams C, Gouras GK, Liby K, Sporn M, Nathan C, Beal MF, Lin MT. Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease: (Journal of Neurochemistry (2009) 109 (502-512)) Journal of Neurochemistry. 109: 1192. DOI: 10.1111/J.1471-4159.2009.06053.X |
0.674 |
|
| 2008 |
Chaturvedi RK, Beal MF. Mitochondrial approaches for neuroprotection. Annals of the New York Academy of Sciences. 1147: 395-412. PMID 19076459 DOI: 10.1196/Annals.1427.027 |
0.581 |
|
| 2008 |
Henchcliffe C, Shungu DC, Mao X, Huang C, Nirenberg MJ, Jenkins BG, Beal MF. Multinuclear magnetic resonance spectroscopy for in vivo assessment of mitochondrial dysfunction in Parkinson's disease. Annals of the New York Academy of Sciences. 1147: 206-20. PMID 19076443 DOI: 10.1196/Annals.1427.037 |
0.349 |
|
| 2008 |
Adhihetty PJ, Beal MF. Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases. Neuromolecular Medicine. 10: 275-90. PMID 19005780 DOI: 10.1007/S12017-008-8053-Y |
0.73 |
|
| 2008 |
Henchcliffe C, Beal MF. Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nature Clinical Practice. Neurology. 4: 600-9. PMID 18978800 DOI: 10.1038/Ncpneuro0924 |
0.386 |
|
| 2008 |
Yang Y, Ouyang Y, Yang L, Beal MF, McQuibban A, Vogel H, Lu B. Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proceedings of the National Academy of Sciences of the United States of America. 105: 7070-5. PMID 18443288 DOI: 10.1073/Pnas.0711845105 |
0.628 |
|
| 2008 |
Calingasan NY, Ho DJ, Wille EJ, Campagna MV, Ruan J, Dumont M, Yang L, Shi Q, Gibson GE, Beal MF. Influence of mitochondrial enzyme deficiency on adult neurogenesis in mouse models of neurodegenerative diseases. Neuroscience. 153: 986-96. PMID 18423880 DOI: 10.1016/J.Neuroscience.2008.02.071 |
0.708 |
|
| 2008 |
Chaturvedi RK, Beal MF. PPAR: a therapeutic target in Parkinson's disease. Journal of Neurochemistry. 106: 506-18. PMID 18384649 DOI: 10.1111/J.1471-4159.2008.05388.X |
0.58 |
|
| 2008 |
Yang L, Calingasan NY, Lorenzo BJ, Beal MF. Attenuation of MPTP neurotoxicity by rolipram, a specific inhibitor of phosphodiesterase IV. Experimental Neurology. 211: 311-4. PMID 18328479 DOI: 10.1016/J.Expneurol.2007.02.010 |
0.641 |
|
| 2008 |
Bogdanov M, Matson WR, Wang L, Matson T, Saunders-Pullman R, Bressman SS, Beal MF. Metabolomic profiling to develop blood biomarkers for Parkinson's disease Brain. 131: 389-396. PMID 18222993 DOI: 10.1093/Brain/Awm304 |
0.309 |
|
| 2008 |
Reddy PH, Beal MF. Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease. Trends in Molecular Medicine. 14: 45-53. PMID 18218341 DOI: 10.1016/J.Molmed.2007.12.002 |
0.356 |
|
| 2008 |
Langley B, D'Annibale MA, Suh K, Ayoub I, Tolhurst A, Bastan B, Yang L, Ko B, Fisher M, Cho S, Beal MF, Ratan RR. Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 163-76. PMID 18171934 DOI: 10.1523/Jneurosci.3200-07.2008 |
0.629 |
|
| 2008 |
Cleren C, Yang L, Lorenzo B, Calingasan NY, Schomer A, Sireci A, Wille EJ, Beal MF. Therapeutic effects of coenzyme Q10 (CoQ10) and reduced CoQ10 in the MPTP model of Parkinsonism. Journal of Neurochemistry. 104: 1613-21. PMID 17973981 DOI: 10.1111/J.1471-4159.2007.05097.X |
0.643 |
|
| 2008 |
Lorenzl S, Buerger K, Hampel H, Beal MF. Profiles of matrix metalloproteinases and their inhibitors in plasma of patients with dementia. International Psychogeriatrics / Ipa. 20: 67-76. PMID 17697439 DOI: 10.1017/S1041610207005790 |
0.544 |
|
| 2007 |
Beal MF. Mitochondria and neurodegeneration. Novartis Foundation Symposium. 287: 183-92; discussion 1. PMID 18074639 DOI: 10.1002/9780470725207.Ch13 |
0.413 |
|
| 2007 |
Stack EC, Dedeoglu A, Smith KM, Cormier K, Kubilus JK, Bogdanov M, Matson WR, Yang L, Jenkins BG, Luthi-Carter R, Kowall NW, Hersch SM, Beal MF, Ferrante RJ. Neuroprotective effects of synaptic modulation in Huntington's disease R6/2 mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 12908-15. PMID 18032664 DOI: 10.1523/Jneurosci.4318-07.2007 |
0.666 |
|
| 2007 |
Strand AD, Baquet ZC, Aragaki AK, Holmans P, Yang L, Cleren C, Beal MF, Jones L, Kooperberg C, Olson JM, Jones KR. Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11758-68. PMID 17959817 DOI: 10.1523/Jneurosci.2461-07.2007 |
0.664 |
|
| 2007 |
Constantinescu R, McDermott MP, Dicenzo R, de Blieck EA, Hyson HC, Beal MF, Bednarczyk EM, Bogdanov M, Metakis LJ, Browne SE, Lorenzo BJ, Ravina B, Kieburtz K. A randomized study of the bioavailability of different formulations of coenzyme Q(10) (ubiquinone). Journal of Clinical Pharmacology. 47: 1580-6. PMID 17925590 DOI: 10.1177/0091270007307571 |
0.425 |
|
| 2007 |
Manfredi G, Beal MF. Merging mitochondria for neuronal survival. Nature Medicine. 13: 1140-1. PMID 17917656 DOI: 10.1038/Nm1007-1140 |
0.319 |
|
| 2007 |
Thomas B, Beal MF. Parkinson's disease. Human Molecular Genetics. 16: R183-94. PMID 17911161 DOI: 10.1093/hmg/ddm159 |
0.522 |
|
| 2007 |
Inoue H, Lin L, Lee X, Shao Z, Mendes S, Snodgrass-Belt P, Sweigard H, Engber T, Pepinsky B, Yang L, Beal MF, Mi S, Isacson O. Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models. Proceedings of the National Academy of Sciences of the United States of America. 104: 14430-5. PMID 17726113 DOI: 10.1073/pnas.0700901104 |
0.628 |
|
| 2007 |
Petri S, Calingasan NY, Alsaied OA, Wille E, Kiaei M, Friedman JE, Baranova O, Chavez JC, Beal MF. The lipophilic metal chelators DP-109 and DP-460 are neuroprotective in a transgenic mouse model of amyotrophic lateral sclerosis. Journal of Neurochemistry. 102: 991-1000. PMID 17630988 DOI: 10.1111/J.1471-4159.2007.04604.X |
0.567 |
|
| 2007 |
Kiaei M, Kipiani K, Calingasan NY, Wille E, Chen J, Heissig B, Rafii S, Lorenzl S, Beal MF. Matrix metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal, glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis. Experimental Neurology. 205: 74-81. PMID 17362932 DOI: 10.1016/J.Expneurol.2007.01.036 |
0.796 |
|
| 2007 |
Kim YS, Choi DH, Block ML, Lorenzl S, Yang L, Kim YJ, Sugama S, Cho BP, Hwang O, Browne SE, Kim SY, Hong JS, Beal MF, Joh TH. A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 179-87. PMID 17116747 DOI: 10.1096/Fj.06-5865Com |
0.804 |
|
| 2007 |
Rodriguez MC, MacDonald JR, Mahoney DJ, Parise G, Beal MF, Tarnopolsky MA. Beneficial effects of creatine, CoQ10, and lipoic acid in mitochondrial disorders. Muscle & Nerve. 35: 235-42. PMID 17080429 DOI: 10.1002/Mus.20688 |
0.327 |
|
| 2007 |
Roy NS, Cleren C, Singh SK, Yang L, Beal MF, Goldman SA. Erratum: Corrigendum: Functional engraftment of human ES cell–derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes Nature Medicine. 13: 385-385. DOI: 10.1038/nm0307-385b |
0.552 |
|
| 2006 |
Beal MF, Bossy-Wetzel E, Finkbeiner S, Fiskum G, Giasson B, Johnson C, Khachaturian ZS, Lee VM, Nicholls D, Reddy H, Reynolds I, Teplow DB, Thal LJ, Trojanowski JQ, Walsh DM, et al. Common threads in neurodegenerative disorders of aging. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 2: 322-6. PMID 19595906 DOI: 10.1016/J.Jalz.2006.08.008 |
0.405 |
|
| 2006 |
Lin MT, Beal MF. Alzheimer's APP mangles mitochondria. Nature Medicine. 12: 1241-3. PMID 17088888 DOI: 10.1038/Nm1106-1241 |
0.539 |
|
| 2006 |
McGill JK, Beal MF. PGC-1alpha, a new therapeutic target in Huntington's disease? Cell. 127: 465-8. PMID 17081970 DOI: 10.1016/J.Cell.2006.10.023 |
0.327 |
|
| 2006 |
Roy NS, Cleren C, Singh SK, Yang L, Beal MF, Goldman SA. Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nature Medicine. 12: 1259-68. PMID 17057709 DOI: 10.1038/Nm1495 |
0.605 |
|
| 2006 |
Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature. 443: 787-95. PMID 17051205 DOI: 10.1038/Nature05292 |
0.568 |
|
| 2006 |
Browne SE, Beal MF. Oxidative damage in Huntington's disease pathogenesis. Antioxidants & Redox Signaling. 8: 2061-73. PMID 17034350 DOI: 10.1089/Ars.2006.8.2061 |
0.597 |
|
| 2006 |
Saydoff JA, Garcia RA, Browne SE, Liu L, Sheng J, Brenneman D, Hu Z, Cardin S, Gonzalez A, von Borstel RW, Gregorio J, Burr H, Beal MF. Oral uridine pro-drug PN401 is neuroprotective in the R6/2 and N171-82Q mouse models of Huntington's disease. Neurobiology of Disease. 24: 455-65. PMID 17011205 DOI: 10.1016/J.Nbd.2006.08.011 |
0.572 |
|
| 2006 |
Petri S, Kiaei M, Damiano M, Hiller A, Wille E, Manfredi G, Calingasan NY, Szeto HH, Beal MF. Cell-permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis. Journal of Neurochemistry. 98: 1141-8. PMID 16895581 DOI: 10.1111/J.1471-4159.2006.04018.X |
0.741 |
|
| 2006 |
Yang Y, Gehrke S, Imai Y, Huang Z, Ouyang Y, Wang JW, Yang L, Beal MF, Vogel H, Lu B. Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proceedings of the National Academy of Sciences of the United States of America. 103: 10793-8. PMID 16818890 DOI: 10.1073/Pnas.0602493103 |
0.646 |
|
| 2006 |
Kwong JQ, Beal MF, Manfredi G. The role of mitochondria in inherited neurodegenerative diseases. Journal of Neurochemistry. 97: 1659-75. PMID 16805775 DOI: 10.1111/J.1471-4159.2006.03990.X |
0.404 |
|
| 2006 |
Browne SE, Yang L, DiMauro JP, Fuller SW, Licata SC, Beal MF. Bioenergetic abnormalities in discrete cerebral motor pathways presage spinal cord pathology in the G93A SOD1 mouse model of ALS. Neurobiology of Disease. 22: 599-610. PMID 16616851 DOI: 10.1016/J.Nbd.2006.01.001 |
0.695 |
|
| 2006 |
Lorenzl S, Narr S, Angele B, Krell HW, Gregorio J, Kiaei M, Pfister HW, Beal MF. The matrix metalloproteinases inhibitor Ro 28-2653 [correction of Ro 26-2853] extends survival in transgenic ALS mice. Experimental Neurology. 200: 166-71. PMID 16516196 DOI: 10.1016/J.Expneurol.2006.01.026 |
0.786 |
|
| 2006 |
Kiaei M, Petri S, Kipiani K, Gardian G, Choi DK, Chen J, Calingasan NY, Schafer P, Muller GW, Stewart C, Hensley K, Beal MF. Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 2467-73. PMID 16510725 DOI: 10.1523/Jneurosci.5253-05.2006 |
0.789 |
|
| 2006 |
Hersch SM, Gevorkian S, Marder K, Moskowitz C, Feigin A, Cox M, Como P, Zimmerman C, Lin M, Zhang L, Ulug AM, Beal MF, Matson W, Bogdanov M, Ebbel E, et al. Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG. Neurology. 66: 250-2. PMID 16434666 DOI: 10.1212/01.Wnl.0000194318.74946.B6 |
0.456 |
|
| 2006 |
Hervias I, Beal MF, Manfredi G. Mitochondrial dysfunction and amyotrophic lateral sclerosis. Muscle & Nerve. 33: 598-608. PMID 16372325 DOI: 10.1002/Mus.20489 |
0.396 |
|
| 2006 |
Klivenyi P, Siwek D, Gardian G, Yang L, Starkov A, Cleren C, Ferrante RJ, Kowall NW, Abeliovich A, Beal MF. Mice lacking alpha-synuclein are resistant to mitochondrial toxins. Neurobiology of Disease. 21: 541-8. PMID 16298531 DOI: 10.1016/J.Nbd.2005.08.018 |
0.811 |
|
| 2006 |
Petri S, Kiaei M, Kipiani K, Chen J, Calingasan NY, Crow JP, Beal MF. Additive neuroprotective effects of a histone deacetylase inhibitor and a catalytic antioxidant in a transgenic mouse model of amyotrophic lateral sclerosis. Neurobiology of Disease. 22: 40-9. PMID 16289867 DOI: 10.1016/J.Nbd.2005.09.013 |
0.804 |
|
| 2005 |
Rozen S, Cudkowicz ME, Bogdanov M, Matson WR, Kristal BS, Beecher C, Harrison S, Vouros P, Flarakos J, Vigneau-Callahan K, Matson TD, Newhall KM, Beal MF, Brown RH, Kaddurah-Daouk R. Metabolomic analysis and signatures in motor neuron disease. Metabolomics : Official Journal of the Metabolomic Society. 1: 101-108. PMID 18820733 DOI: 10.1007/S11306-005-4810-1 |
0.355 |
|
| 2005 |
Kiaei M, Kipiani K, Petri S, Chen J, Calingasan NY, Beal MF. Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis. Neuro-Degenerative Diseases. 2: 246-54. PMID 16909005 DOI: 10.1159/000090364 |
0.802 |
|
| 2005 |
Kim SY, Marekov L, Bubber P, Browne SE, Stavrovskaya I, Lee J, Steinert PM, Blass JP, Beal MF, Gibson GE, Cooper AJ. Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain. Neurochemical Research. 30: 1245-55. PMID 16341586 DOI: 10.1007/S11064-005-8796-X |
0.547 |
|
| 2005 |
Li C, Beal MF. Leucine-rich repeat kinase 2: a new player with a familiar theme for Parkinson's disease pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. 102: 16535-6. PMID 16275903 DOI: 10.1073/Pnas.0508350102 |
0.377 |
|
| 2005 |
Reddy PH, Beal MF. Are mitochondria critical in the pathogenesis of Alzheimer's disease? Brain Research. Brain Research Reviews. 49: 618-32. PMID 16269322 DOI: 10.1016/J.Brainresrev.2005.03.004 |
0.329 |
|
| 2005 |
Nathan C, Calingasan N, Nezezon J, Ding A, Lucia MS, La Perle K, Fuortes M, Lin M, Ehrt S, Kwon NS, Chen J, Vodovotz Y, Kipiani K, Beal MF. Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase. The Journal of Experimental Medicine. 202: 1163-9. PMID 16260491 DOI: 10.1084/Jem.20051529 |
0.793 |
|
| 2005 |
Cantuti-Castelvetri I, Lin MT, Zheng K, Keller-McGandy CE, Betensky RA, Johns DR, Beal MF, Standaert DG, Simon DK. Somatic mitochondrial DNA mutations in single neurons and glia. Neurobiology of Aging. 26: 1343-55. PMID 16243605 DOI: 10.1016/J.Neurobiolaging.2004.11.008 |
0.605 |
|
| 2005 |
Beal MF. Mitochondria take center stage in aging and neurodegeneration. Annals of Neurology. 58: 495-505. PMID 16178023 DOI: 10.1002/Ana.20624 |
0.422 |
|
| 2005 |
Yang Y, Gehrke S, Haque ME, Imai Y, Kosek J, Yang L, Beal MF, Nishimura I, Wakamatsu K, Ito S, Takahashi R, Lu B. Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Proceedings of the National Academy of Sciences of the United States of America. 102: 13670-5. PMID 16155123 DOI: 10.1073/Pnas.0504610102 |
0.609 |
|
| 2005 |
Jenkins BG, Andreassen OA, Dedeoglu A, Leavitt B, Hayden M, Borchelt D, Ross CA, Ferrante RJ, Beal MF. Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease. Journal of Neurochemistry. 95: 553-62. PMID 16135087 DOI: 10.1111/J.1471-4159.2005.03411.X |
0.49 |
|
| 2005 |
Cleren C, Starkov AA, Calingasan NY, Lorenzo BJ, Chen J, Beal MF. Promethazine protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. Neurobiology of Disease. 20: 701-8. PMID 16126396 DOI: 10.1016/J.Nbd.2005.05.022 |
0.422 |
|
| 2005 |
Son JH, Kawamata H, Yoo MS, Kim DJ, Lee YK, Kim S, Dawson TM, Zhang H, Sulzer D, Yang L, Beal MF, Degiorgio LA, Chun HS, Baker H, Peng C. Neurotoxicity and behavioral deficits associated with Septin 5 accumulation in dopaminergic neurons. Journal of Neurochemistry. 94: 1040-53. PMID 16092945 DOI: 10.1111/J.1471-4159.2005.03257.X |
0.657 |
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| 2005 |
Cleren C, Calingasan NY, Chen J, Beal MF. Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity. Journal of Neurochemistry. 94: 995-1004. PMID 16092942 DOI: 10.1111/J.1471-4159.2005.03253.X |
0.434 |
|
| 2005 |
Crow JP, Calingasan NY, Chen J, Hill JL, Beal MF. Manganese porphyrin given at symptom onset markedly extends survival of ALS mice. Annals of Neurology. 58: 258-65. PMID 16049935 DOI: 10.1002/Ana.20552 |
0.38 |
|
| 2005 |
Aguirre N, Beal MF, Matson WR, Bogdanov MB. Increased oxidative damage to DNA in an animal model of amyotrophic lateral sclerosis. Free Radical Research. 39: 383-8. PMID 16028363 DOI: 10.1080/10715760400027979 |
0.6 |
|
| 2005 |
Kleiner-Fisman G, Calingasan NY, Putt M, Chen J, Beal MF, Lang AE. Alterations of striatal neurons in benign hereditary chorea. Movement Disorders : Official Journal of the Movement Disorder Society. 20: 1353-7. PMID 15986422 DOI: 10.1002/Mds.20577 |
0.322 |
|
| 2005 |
Gibson GE, Blass JP, Beal MF, Bunik V. The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration. Molecular Neurobiology. 31: 43-63. PMID 15953811 DOI: 10.1385/Mn:31:1-3:043 |
0.413 |
|
| 2005 |
Calingasan NY, Chen J, Kiaei M, Beal MF. Beta-amyloid 42 accumulation in the lumbar spinal cord motor neurons of amyotrophic lateral sclerosis patients. Neurobiology of Disease. 19: 340-7. PMID 15837590 DOI: 10.1016/J.Nbd.2005.01.012 |
0.318 |
|
| 2005 |
Kiaei M, Kipiani K, Petri S, Choi DK, Chen J, Calingasan NY, Beal MF. Integrative role of cPLA with COX-2 and the effect of non-steriodal anti-inflammatory drugs in a transgenic mouse model of amyotrophic lateral sclerosis. Journal of Neurochemistry. 93: 403-11. PMID 15816863 DOI: 10.1111/J.1471-4159.2005.03024.X |
0.791 |
|
| 2005 |
Kim YS, Kim SS, Cho JJ, Choi DH, Hwang O, Shin DH, Chun HS, Beal MF, Joh TH. Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 3701-11. PMID 15814801 DOI: 10.1523/Jneurosci.4346-04.2005 |
0.544 |
|
| 2005 |
Vijayvergiya C, Beal MF, Buck J, Manfredi G. Mutant superoxide dismutase 1 forms aggregates in the brain mitochondrial matrix of amyotrophic lateral sclerosis mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2463-70. PMID 15758154 DOI: 10.1523/Jneurosci.4385-04.2005 |
0.398 |
|
| 2005 |
Langley B, Gensert JM, Beal MF, Ratan RR. Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents. Current Drug Targets. Cns and Neurological Disorders. 4: 41-50. PMID 15723612 DOI: 10.2174/1568007053005091 |
0.304 |
|
| 2005 |
Beal MF. Oxidative damage as an early marker of Alzheimer's disease and mild cognitive impairment. Neurobiology of Aging. 26: 585-6. PMID 15708432 DOI: 10.1016/J.Neurobiolaging.2004.09.022 |
0.312 |
|
| 2005 |
Kiaei M, Kipiani K, Chen J, Calingasan NY, Beal MF. Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis. Experimental Neurology. 191: 331-6. PMID 15649489 DOI: 10.1016/J.Expneurol.2004.10.007 |
0.764 |
|
| 2005 |
Andrews ZB, Horvath B, Barnstable CJ, Elsworth J, Elseworth J, Yang L, Beal MF, Roth RH, Matthews RT, Horvath TL. Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 184-91. PMID 15634780 DOI: 10.1523/Jneurosci.4269-04.2005 |
0.628 |
|
| 2005 |
Yang L, Calingasan NY, Chen J, Ley JJ, Becker DA, Beal MF. A novel azulenyl nitrone antioxidant protects against MPTP and 3-nitropropionic acid neurotoxicities. Experimental Neurology. 191: 86-93. PMID 15589515 DOI: 10.1016/J.Expneurol.2004.07.012 |
0.67 |
|
| 2005 |
Gardian G, Browne SE, Choi DK, Klivenyi P, Gregorio J, Kubilus JK, Ryu H, Langley B, Ratan RR, Ferrante RJ, Beal MF. Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease. The Journal of Biological Chemistry. 280: 556-63. PMID 15494404 DOI: 10.1074/Jbc.M410210200 |
0.81 |
|
| 2004 |
Klivenyi P, Gardian G, Calingasan NY, Yang L, von Borstel R, Saydoff J, Browne SE, Beal MF. Neuroprotective effects of oral administration of triacetyluridine against MPTP neurotoxicity. Neuromolecular Medicine. 6: 87-92. PMID 15970626 DOI: 10.1385/Nmm:6:2-3:087 |
0.821 |
|
| 2004 |
Gardian G, Yang L, Cleren C, Calingasan NY, Klivenyi P, Beal MF. Neuroprotective effects of phenylbutyrate against MPTP neurotoxicity. Neuromolecular Medicine. 5: 235-41. PMID 15626823 DOI: 10.1385/Nmm:5:3:235 |
0.813 |
|
| 2004 |
Ferrante RJ, Ryu H, Kubilus JK, D'Mello S, Sugars KL, Lee J, Lu P, Smith K, Browne S, Beal MF, Kristal BS, Stavrovskaya IG, Hewett S, Rubinsztein DC, Langley B, et al. Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10335-42. PMID 15548647 DOI: 10.1523/Jneurosci.2599-04.2004 |
0.566 |
|
| 2004 |
Martinat C, Shendelman S, Jonason A, Leete T, Beal MF, Yang L, Floss T, Abeliovich A. Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism. Plos Biology. 2: e327. PMID 15502868 DOI: 10.1371/Journal.Pbio.0020327 |
0.648 |
|
| 2004 |
Yang L, Sugama S, Mischak RP, Kiaei M, Bizat N, Brouillet E, Joh TH, Beal MF. A novel systemically active caspase inhibitor attenuates the toxicities of MPTP, malonate, and 3NP in vivo. Neurobiology of Disease. 17: 250-9. PMID 15474362 DOI: 10.1016/J.Nbd.2004.07.021 |
0.747 |
|
| 2004 |
Beal MF. Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment. Journal of Bioenergetics and Biomembranes. 36: 381-6. PMID 15377876 DOI: 10.1023/B:Jobb.0000041772.74810.92 |
0.407 |
|
| 2004 |
Kristal BS, Stavrovskaya IG, Narayanan MV, Krasnikov BF, Brown AM, Beal MF, Friedlander RM. The mitochondrial permeability transition as a target for neuroprotection. Journal of Bioenergetics and Biomembranes. 36: 309-12. PMID 15377863 DOI: 10.1023/B:Jobb.0000041759.35731.70 |
0.337 |
|
| 2004 |
Kiaei M, Bush AI, Morrison BM, Morrison JH, Cherny RA, Volitakis I, Beal MF, Gordon JW. Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of amyotrophic lateral sclerosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 7945-50. PMID 15356208 DOI: 10.1523/Jneurosci.2000-04.2004 |
0.327 |
|
| 2004 |
Starkov AA, Fiskum G, Chinopoulos C, Lorenzo BJ, Browne SE, Patel MS, Beal MF. Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 7779-88. PMID 15356189 DOI: 10.1523/Jneurosci.1899-04.2004 |
0.522 |
|
| 2004 |
Stavrovskaya IG, Narayanan MV, Zhang W, Krasnikov BF, Heemskerk J, Young SS, Blass JP, Brown AM, Beal MF, Friedlander RM, Kristal BS. Clinically approved heterocyclics act on a mitochondrial target and reduce stroke-induced pathology. The Journal of Experimental Medicine. 200: 211-22. PMID 15263028 DOI: 10.1084/Jem.20032053 |
0.325 |
|
| 2004 |
Coskun PE, Beal MF, Wallace DC. Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication. Proceedings of the National Academy of Sciences of the United States of America. 101: 10726-31. PMID 15247418 DOI: 10.1073/Pnas.0403649101 |
0.31 |
|
| 2004 |
Zhu S, Li M, Figueroa BE, Liu A, Stavrovskaya IG, Pasinelli P, Beal MF, Brown RH, Kristal BS, Ferrante RJ, Friedlander RM. Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 5909-12. PMID 15229238 DOI: 10.1523/Jneurosci.1278-04.2004 |
0.385 |
|
| 2004 |
Beal MF, Ferrante RJ. Experimental therapeutics in transgenic mouse models of Huntington's disease. Nature Reviews. Neuroscience. 5: 373-84. PMID 15100720 DOI: 10.1038/Nrn1386 |
0.377 |
|
| 2004 |
Lorenzl S, Calingasan N, Yang L, Albers DS, Shugama S, Gregorio J, Krell HW, Chirichigno J, Joh T, Beal MF. Matrix metalloproteinase-9 is elevated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice. Neuromolecular Medicine. 5: 119-32. PMID 15075439 DOI: 10.1385/Nmm:5:2:119 |
0.721 |
|
| 2004 |
Klivenyi P, Calingasan NY, Starkov A, Stavrovskaya IG, Kristal BS, Yang L, Wieringa B, Beal MF. Neuroprotective mechanisms of creatine occur in the absence of mitochondrial creatine kinase. Neurobiology of Disease. 15: 610-7. PMID 15056469 DOI: 10.1016/J.Nbd.2003.12.014 |
0.741 |
|
| 2004 |
Beal MF. Therapeutic effects of coenzyme Q10 in neurodegenerative diseases. Methods in Enzymology. 382: 473-87. PMID 15047118 DOI: 10.1016/S0076-6879(04)82026-3 |
0.446 |
|
| 2004 |
Browne SE, Beal MF. The energetics of Huntington's disease. Neurochemical Research. 29: 531-46. PMID 15038601 DOI: 10.1023/B:Nere.0000014824.04728.Dd |
0.58 |
|
| 2004 |
Browne SE, Roberts LJ, Dennery PA, Doctrow SR, Beal MF, Barlow C, Levine RL. Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia mice. Free Radical Biology & Medicine. 36: 938-42. PMID 15019978 DOI: 10.1016/J.Freeradbiomed.2004.01.003 |
0.562 |
|
| 2004 |
Klivenyi P, Starkov AA, Calingasan NY, Gardian G, Browne SE, Yang L, Bubber P, Gibson GE, Patel MS, Beal MF. Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity. Journal of Neurochemistry. 88: 1352-60. PMID 15009635 DOI: 10.1046/J.1471-4159.2003.02263.X |
0.83 |
|
| 2004 |
Lorenzl S, Albers DS, Chirichigno JW, Augood SJ, Beal MF. Elevated levels of matrix metalloproteinases-9 and -1 and of tissue inhibitors of MMPs, TIMP-1 and TIMP-2 in postmortem brain tissue of progressive supranuclear palsy. Journal of the Neurological Sciences. 218: 39-45. PMID 14759631 DOI: 10.1016/J.Jns.2003.10.015 |
0.557 |
|
| 2004 |
Klivenyi P, Kiaei M, Gardian G, Calingasan NY, Beal MF. Additive neuroprotective effects of creatine and cyclooxygenase 2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis. Journal of Neurochemistry. 88: 576-82. PMID 14720207 DOI: 10.1046/J.1471-4159.2003.02160.X |
0.807 |
|
| 2004 |
Uluğ AM, Grünewald T, Lin MT, Kamal AK, Filippi CG, Zimmerman RD, Beal MF. Diffusion tensor imaging in the diagnosis of primary lateral sclerosis. Journal of Magnetic Resonance Imaging : Jmri. 19: 34-9. PMID 14696218 DOI: 10.1002/Jmri.10433 |
0.451 |
|
| 2004 |
Simon DK, Lin MT, Zheng L, Liu GJ, Ahn CH, Kim LM, Mauck WM, Twu F, Beal MF, Johns DR. Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease. Neurobiology of Aging. 25: 71-81. PMID 14675733 DOI: 10.1016/S0197-4580(03)00037-X |
0.624 |
|
| 2004 |
Beal MF. Bioenergetics in the pathogenesis of neurodegeneration Journal of Neurochemistry. 77: iv-iv. DOI: 10.1111/J.1471-4159.2001.00001.X |
0.44 |
|
| 2004 |
Beal MF. PL-2-1 Oxidative mechanisms, inflammation, and Alzheimer's disease pathogenesis Neurobiology of Aging. 25: S24. DOI: 10.1016/S0197-4580(04)80076-9 |
0.345 |
|
| 2003 |
Beal MF, Shults CW. Effects of Coenzyme Q10 in Huntington's disease and early Parkinson's disease. Biofactors (Oxford, England). 18: 153-61. PMID 14695931 DOI: 10.1002/Biof.5520180218 |
0.334 |
|
| 2003 |
Klivenyi P, Gardian G, Calingasan NY, Yang L, Beal MF. Additive neuroprotective effects of creatine and a cyclooxygenase 2 inhibitor against dopamine depletion in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. Journal of Molecular Neuroscience : Mn. 21: 191-8. PMID 14645986 DOI: 10.1385/Jmn:21:3:191 |
0.814 |
|
| 2003 |
Andreassen OA, Ferrante RJ, Aamo TO, Beal MF, Jørgensen HA. Oral dyskinesias and histopathological alterations in substantia nigra after long-term haloperidol treatment of old rats. Neuroscience. 122: 717-25. PMID 14622915 DOI: 10.1016/J.Neuroscience.2003.08.058 |
0.354 |
|
| 2003 |
Yang L, Sugama S, Chirichigno JW, Gregorio J, Lorenzl S, Shin DH, Browne SE, Shimizu Y, Joh TH, Beal MF, Albers DS. Minocycline enhances MPTP toxicity to dopaminergic neurons. Journal of Neuroscience Research. 74: 278-85. PMID 14515357 DOI: 10.1002/Jnr.10709 |
0.791 |
|
| 2003 |
Barberi T, Klivenyi P, Calingasan NY, Lee H, Kawamata H, Loonam K, Perrier AL, Bruses J, Rubio ME, Topf N, Tabar V, Harrison NL, Beal MF, Moore MA, Studer L. Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice. Nature Biotechnology. 21: 1200-7. PMID 14502203 DOI: 10.1038/Nbt870 |
0.581 |
|
| 2003 |
Diano S, Matthews RT, Patrylo P, Yang L, Beal MF, Barnstable CJ, Horvath TL. Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning. Endocrinology. 144: 5014-21. PMID 12960023 DOI: 10.1210/En.2003-0667 |
0.639 |
|
| 2003 |
Beal MF. Mitochondria, oxidative damage, and inflammation in Parkinson's disease. Annals of the New York Academy of Sciences. 991: 120-31. PMID 12846981 DOI: 10.1111/J.1749-6632.2003.Tb07470.X |
0.351 |
|
| 2003 |
Klivenyi P, Ferrante RJ, Gardian G, Browne S, Chabrier PE, Beal MF. Increased survival and neuroprotective effects of BN82451 in a transgenic mouse model of Huntington's disease. Journal of Neurochemistry. 86: 267-72. PMID 12807446 DOI: 10.1046/J.1471-4159.2003.T01-1-01868.X |
0.823 |
|
| 2003 |
Dedeoglu A, Kubilus JK, Yang L, Ferrante KL, Hersch SM, Beal MF, Ferrante RJ. Creatine therapy provides neuroprotection after onset of clinical symptoms in Huntington's disease transgenic mice. Journal of Neurochemistry. 85: 1359-67. PMID 12787055 DOI: 10.1046/J.1471-4159.2003.01706.X |
0.642 |
|
| 2003 |
Lorenzl S, De Pasquale G, Segal AZ, Beal MF. Dysregulation of the levels of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in the early phase of cerebral ischemia. Stroke; a Journal of Cerebral Circulation. 34: e37-8; author reply . PMID 12750528 DOI: 10.1161/01.Str.0000075563.45920.24 |
0.55 |
|
| 2003 |
Zhang L, Ulug AM, Zimmerman RD, Lin MT, Rubin M, Beal MF. The diagnostic utility of FLAIR imaging in clinically verified amyotrophic lateral sclerosis. Journal of Magnetic Resonance Imaging : Jmri. 17: 521-7. PMID 12720261 DOI: 10.1002/Jmri.10293 |
0.48 |
|
| 2003 |
Lorenzl S, Albers DS, Relkin N, Ngyuen T, Hilgenberg SL, Chirichigno J, Cudkowicz ME, Beal MF. Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer's disease. Neurochemistry International. 43: 191-6. PMID 12689599 DOI: 10.1016/S0197-0186(03)00004-4 |
0.567 |
|
| 2003 |
Kaur D, Yantiri F, Rajagopalan S, Kumar J, Mo JQ, Boonplueang R, Viswanath V, Jacobs R, Yang L, Beal MF, DiMonte D, Volitaskis I, Ellerby L, Cherny RA, Bush AI, et al. Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease. Neuron. 37: 899-909. PMID 12670420 DOI: 10.1016/S0896-6273(03)00126-0 |
0.589 |
|
| 2003 |
Beal MF. Bioenergetic approaches for neuroprotection in Parkinson's disease. Annals of Neurology. 53: S39-47; discussion S. PMID 12666097 DOI: 10.1002/Ana.10479 |
0.365 |
|
| 2003 |
Wu AS, Kiaei M, Aguirre N, Crow JP, Calingasan NY, Browne SE, Beal MF. Iron porphyrin treatment extends survival in a transgenic animal model of amyotrophic lateral sclerosis. Journal of Neurochemistry. 85: 142-50. PMID 12641736 DOI: 10.1046/J.1471-4159.2003.01639.X |
0.709 |
|
| 2003 |
Gajewski CD, Lin MT, Cudkowicz ME, Beal MF, Manfredi G. Mitochondrial DNA from platelets of sporadic ALS patients restores normal respiratory functions in rho(0) cells. Experimental Neurology. 179: 229-35. PMID 12618129 DOI: 10.1016/S0014-4886(02)00022-5 |
0.534 |
|
| 2003 |
Lorenzl S, Albers DS, LeWitt PA, Chirichigno JW, Hilgenberg SL, Cudkowicz ME, Beal MF. Tissue inhibitors of matrix metalloproteinases are elevated in cerebrospinal fluid of neurodegenerative diseases. Journal of the Neurological Sciences. 207: 71-6. PMID 12614934 DOI: 10.1016/S0022-510X(02)00398-2 |
0.551 |
|
| 2003 |
Sugama S, Yang L, Cho BP, DeGiorgio LA, Lorenzl S, Albers DS, Beal MF, Volpe BT, Joh TH. Age-related microglial activation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration in C57BL/6 mice. Brain Research. 964: 288-94. PMID 12576189 DOI: 10.1016/S0006-8993(02)04085-4 |
0.711 |
|
| 2003 |
Klivenyi P, Ferrante RJ, Gardian G, Browne S, Chabrier PE, Beal MF. Erratum: Increased survival and neuroprotective effects of BN82451 in a transgenic mouse model of Huntington's disease (Journal of Neurochemistry (2003) 86 (267-272)) Journal of Neurochemistry. 87. DOI: 10.1046/J.1471-4159.2003.01868.X |
0.805 |
|
| 2002 |
Andreassen OA, Dedeoglu A, Stanojevic V, Hughes DB, Browne SE, Leech CA, Ferrante RJ, Habener JF, Beal MF, Thomas MK. Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expression. Neurobiology of Disease. 11: 410-24. PMID 12586550 DOI: 10.1006/Nbdi.2002.0562 |
0.561 |
|
| 2002 |
Browne SE, Beal MF. Toxin-induced mitochondrial dysfunction. International Review of Neurobiology. 53: 243-79. PMID 12512343 DOI: 10.1016/S0074-7742(02)53010-5 |
0.548 |
|
| 2002 |
Lorenzl S, Albers DS, Narr S, Chirichigno J, Beal MF. Expression of MMP-2, MMP-9, and MMP-1 and their endogenous counterregulators TIMP-1 and TIMP-2 in postmortem brain tissue of Parkinson's disease. Experimental Neurology. 178: 13-20. PMID 12460604 DOI: 10.1006/Exnr.2002.8019 |
0.777 |
|
| 2002 |
Takahashi RH, Milner TA, Li F, Nam EE, Edgar MA, Yamaguchi H, Beal MF, Xu H, Greengard P, Gouras GK. Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. The American Journal of Pathology. 161: 1869-79. PMID 12414533 DOI: 10.1016/S0002-9440(10)64463-X |
0.589 |
|
| 2002 |
Dedeoglu A, Kubilus JK, Jeitner TM, Matson SA, Bogdanov M, Kowall NW, Matson WR, Cooper AJ, Ratan RR, Beal MF, Hersch SM, Ferrante RJ. Therapeutic effects of cystamine in a murine model of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 8942-50. PMID 12388601 DOI: 10.1523/Jneurosci.22-20-08942.2002 |
0.422 |
|
| 2002 |
Chirichigno JW, Manfredi G, Beal MF, Albers DS. Stress-induced mitochondrial depolarization and oxidative damage in PSP cybrids. Brain Research. 951: 31-5. PMID 12231453 DOI: 10.1016/S0006-8993(02)03101-3 |
0.358 |
|
| 2002 |
Montine TJ, Neely MD, Quinn JF, Beal MF, Markesbery WR, Roberts LJ, Morrow JD. Lipid peroxidation in aging brain and Alzheimer's disease. Free Radical Biology & Medicine. 33: 620-6. PMID 12208348 DOI: 10.1016/S0891-5849(02)00807-9 |
0.327 |
|
| 2002 |
Kiechle T, Dedeoglu A, Kubilus J, Kowall NW, Beal MF, Friedlander RM, Hersch SM, Ferrante RJ. Cytochrome C and caspase-9 expression in Huntington's disease. Neuromolecular Medicine. 1: 183-95. PMID 12095160 DOI: 10.1385/Nmm:1:3:183 |
0.398 |
|
| 2002 |
Dedeoglu A, Ferrante RJ, Andreassen OA, Dillmann WH, Beal MF. Mice overexpressing 70-kDa heat shock protein show increased resistance to malonate and 3-nitropropionic acid. Experimental Neurology. 176: 262-5. PMID 12093104 DOI: 10.1006/Exnr.2002.7933 |
0.476 |
|
| 2002 |
Beal MF. Coenzyme Q10 as a possible treatment for neurodegenerative diseases. Free Radical Research. 36: 455-60. PMID 12069110 DOI: 10.1080/10715760290021315 |
0.447 |
|
| 2002 |
Mattiazzi M, D'Aurelio M, Gajewski CD, Martushova K, Kiaei M, Beal MF, Manfredi G. Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice. The Journal of Biological Chemistry. 277: 29626-33. PMID 12050154 DOI: 10.1074/Jbc.M203065200 |
0.426 |
|
| 2002 |
Mecocci P, Polidori MC, Cherubini A, Ingegni T, Mattioli P, Catani M, Rinaldi P, Cecchetti R, Stahl W, Senin U, Beal MF. Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease. Archives of Neurology. 59: 794-8. PMID 12020262 DOI: 10.1001/Archneur.59.5.794 |
0.597 |
|
| 2002 |
Wendt S, Dedeoglu A, Speer O, Wallimann T, Beal MF, Andreassen OA. Reduced creatine kinase activity in transgenic amyotrophic lateral sclerosis mice. Free Radical Biology & Medicine. 32: 920-6. PMID 11978494 DOI: 10.1016/S0891-5849(02)00784-0 |
0.505 |
|
| 2002 |
Beal MF. Oxidatively modified proteins in aging and disease. Free Radical Biology & Medicine. 32: 797-803. PMID 11978481 DOI: 10.1016/S0891-5849(02)00780-3 |
0.376 |
|
| 2002 |
Ferrante RJ, Andreassen OA, Dedeoglu A, Ferrante KL, Jenkins BG, Hersch SM, Beal MF. Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 1592-9. PMID 11880489 DOI: 10.1523/Jneurosci.22-05-01592.2002 |
0.492 |
|
| 2002 |
Cantuti-Castelvetri I, Keller-McGandy CE, Albers DS, Beal MF, Vonsattel JP, Standaert DG, Augood SJ. Expression and activity of antioxidants in the brain in progressive supranuclear palsy. Brain Research. 930: 170-81. PMID 11879807 DOI: 10.1016/S0006-8993(02)02244-8 |
0.338 |
|
| 2002 |
Albers DS, Beal MF. Mitochondrial dysfunction in progressive supranuclear palsy. Neurochemistry International. 40: 559-64. PMID 11850113 DOI: 10.1016/S0197-0186(01)00126-7 |
0.401 |
|
| 2002 |
Wiedemann FR, Manfredi G, Mawrin C, Beal MF, Schon EA. Mitochondrial DNA and respiratory chain function in spinal cords of ALS patients. Journal of Neurochemistry. 80: 616-25. PMID 11841569 DOI: 10.1046/J.0022-3042.2001.00731.X |
0.331 |
|
| 2002 |
Vives-Bauza C, Andreu AL, Manfredi G, Beal MF, Janetzky B, Gruenewald TH, Lin MT. Sequence analysis of the entire mitochondrial genome in Parkinson's disease. Biochemical and Biophysical Research Communications. 290: 1593-601. PMID 11820805 DOI: 10.1006/Bbrc.2002.6388 |
0.512 |
|
| 2002 |
Lin MT, Simon DK, Ahn CH, Kim LM, Beal MF. High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain. Human Molecular Genetics. 11: 133-45. PMID 11809722 DOI: 10.1093/Hmg/11.2.133 |
0.61 |
|
| 2001 |
Fanò G, Mecocci P, Vecchiet J, Belia S, Fulle S, Polidori MC, Felzani G, Senin U, Vecchiet L, Beal MF. Age and sex influence on oxidative damage and functional status in human skeletal muscle. Journal of Muscle Research and Cell Motility. 22: 345-51. PMID 11808774 DOI: 10.1023/A:1013122805060 |
0.476 |
|
| 2001 |
Bogdanov MB, Andreassen OA, Dedeoglu A, Ferrante RJ, Beal MF. Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease. Journal of Neurochemistry. 79: 1246-9. PMID 11752065 DOI: 10.1046/J.1471-4159.2001.00689.X |
0.516 |
|
| 2001 |
Park LC, Albers DS, Xu H, Lindsay JG, Beal MF, Gibson GE. Mitochondrial impairment in the cerebellum of the patients with progressive supranuclear palsy. Journal of Neuroscience Research. 66: 1028-34. PMID 11746433 DOI: 10.1002/Jnr.10062 |
0.378 |
|
| 2001 |
Jeitner TM, Bogdanov MB, Matson WR, Daikhin Y, Yudkoff M, Folk JE, Steinman L, Browne SE, Beal MF, Blass JP, Cooper AJ. N(epsilon)-(gamma-L-glutamyl)-L-lysine (GGEL) is increased in cerebrospinal fluid of patients with Huntington's disease. Journal of Neurochemistry. 79: 1109-12. PMID 11739625 DOI: 10.1046/J.1471-4159.2001.00673.X |
0.504 |
|
| 2001 |
Viswanath V, Wu Y, Boonplueang R, Chen S, Stevenson FF, Yantiri F, Yang L, Beal MF, Andersen JK. Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 9519-28. PMID 11739563 DOI: 10.1523/Jneurosci.21-24-09519.2001 |
0.638 |
|
| 2001 |
Andreassen OA, Ferrante RJ, Dedeoglu A, Beal MF. Lipoic acid improves survival in transgenic mouse models of Huntington's disease. Neuroreport. 12: 3371-3. PMID 11711888 DOI: 10.1097/00001756-200110290-00044 |
0.424 |
|
| 2001 |
Ferrante RJ, Klein AM, Dedeoglu A, Beal MF. Therapeutic efficacy of EGb761 (Gingko biloba extract) in a transgenic mouse model of amyotrophic lateral sclerosis. Journal of Molecular Neuroscience : Mn. 17: 89-96. PMID 11665866 DOI: 10.1385/Jmn:17:1:89 |
0.381 |
|
| 2001 |
D'Aurelio M, Pallotti F, Barrientos A, Gajewski CD, Kwong JQ, Bruno C, Beal MF, Manfredi G. In vivo regulation of oxidative phosphorylation in cells harboring a stop-codon mutation in mitochondrial DNA-encoded cytochrome c oxidase subunit I. The Journal of Biological Chemistry. 276: 46925-32. PMID 11595737 DOI: 10.1074/Jbc.M106429200 |
0.304 |
|
| 2001 |
Andreassen OA, Ferrante RJ, Huang HM, Dedeoglu A, Park L, Ferrante KL, Kwon J, Borchelt DR, Ross CA, Gibson GE, Beal MF. Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease. Annals of Neurology. 50: 112-7. PMID 11456300 DOI: 10.1002/Ana.1085 |
0.527 |
|
| 2001 |
Andreassen OA, Dedeoglu A, Ferrante RJ, Jenkins BG, Ferrante KL, Thomas M, Friedlich A, Browne SE, Schilling G, Borchelt DR, Hersch SM, Ross CA, Beal MF. Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease. Neurobiology of Disease. 8: 479-91. PMID 11447996 DOI: 10.1006/Nbdi.2001.0406 |
0.778 |
|
| 2001 |
Gouras GK, Beal MF. Metal chelator decreases Alzheimer beta-amyloid plaques. Neuron. 30: 641-2. PMID 11430794 DOI: 10.1016/S0896-6273(01)00330-0 |
0.576 |
|
| 2001 |
Tarnopolsky MA, Beal MF. Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders. Annals of Neurology. 49: 561-74. PMID 11357946 DOI: 10.1002/Ana.1028 |
0.369 |
|
| 2001 |
Simon DK, Lin MT, Ahn CH, Liu GJ, Gibson GE, Beal MF, Johns DR. Low mutational burden of individual acquired mitochondrial DNA mutations in brain. Genomics. 73: 113-6. PMID 11352572 DOI: 10.1006/Geno.2001.6515 |
0.573 |
|
| 2001 |
Beal MF. Experimental models of Parkinson's disease. Nature Reviews. Neuroscience. 2: 325-34. PMID 11331916 DOI: 10.1038/35072550 |
0.396 |
|
| 2001 |
Gasparini L, Gouras GK, Wang R, Gross RS, Beal MF, Greengard P, Xu H. Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 2561-70. PMID 11306609 |
0.664 |
|
| 2001 |
Andreassen OA, Jenkins BG, Dedeoglu A, Ferrante KL, Bogdanov MB, Kaddurah-Daouk R, Beal MF. Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation. Journal of Neurochemistry. 77: 383-90. PMID 11299300 DOI: 10.1046/J.1471-4159.2001.00188.X |
0.483 |
|
| 2001 |
Andreassen OA, Dedeoglu A, Friedlich A, Ferrante KL, Hughes D, Szabo C, Beal MF. Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylselegiline, trientine, and lipoic acid in transgenic ALS mice. Experimental Neurology. 168: 419-24. PMID 11259130 DOI: 10.1006/Exnr.2001.7633 |
0.731 |
|
| 2001 |
Andreassen OA, Ferrante RJ, Klivenyi P, Klein AM, Dedeoglu A, Albers DS, Kowall NW, Beal MF. Transgenic ALS mice show increased vulnerability to the mitochondrial toxins MPTP and 3-nitropropionic acid. Experimental Neurology. 168: 356-63. PMID 11259123 DOI: 10.1006/Exnr.2001.7627 |
0.685 |
|
| 2001 |
Albers DS, Swerdlow RH, Manfredi G, Gajewski C, Yang L, Parker WD, Beal MF. Further evidence for mitochondrial dysfunction in progressive supranuclear palsy. Experimental Neurology. 168: 196-8. PMID 11170735 DOI: 10.1006/Exnr.2000.7607 |
0.611 |
|
| 2001 |
Andreassen OA, Ferrante RJ, Dedeoglu A, Albers DW, Klivenyi P, Carlson EJ, Epstein CJ, Beal MF. Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP. Experimental Neurology. 167: 189-95. PMID 11161607 DOI: 10.1006/Exnr.2000.7525 |
0.693 |
|
| 2001 |
Beal MF, Hantraye P. Novel therapies in the search for a cure for Huntington's disease. Proceedings of the National Academy of Sciences of the United States of America. 98: 3-4. PMID 11136240 DOI: 10.1073/Pnas.98.1.3 |
0.331 |
|
| 2001 |
Gasparini L, Gouras GK, Wang R, Gross RS, Beal MF, Greengard P, Xu H. Stimulation of β-Amyloid Precursor Protein Trafficking by Insulin Reduces Intraneuronal β-Amyloid and Requires Mitogen-Activated Protein Kinase Signaling The Journal of Neuroscience. 21: 2561-2570. DOI: 10.1523/Jneurosci.21-08-02561.2001 |
0.689 |
|
| 2000 |
Friedlich AL, Beal MF. Prospects for redox-based therapy in neurodegenerative diseases. Neurotoxicity Research. 2: 229-37. PMID 16787843 DOI: 10.1007/Bf03033796 |
0.712 |
|
| 2000 |
Beal MF, Palomo T, Kostrzewa RM, Archer T. Neuroprotective and neurorestorative strategies for neuronal injury. Neurotoxicity Research. 2: 71-84. PMID 16787833 DOI: 10.1007/Bf03033786 |
0.429 |
|
| 2000 |
Fulle S, Mecocci P, Fanó G, Vecchiet I, Vecchini A, Racciotti D, Cherubini A, Pizzigallo E, Vecchiet L, Senin U, Beal MF. Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome. Free Radical Biology & Medicine. 29: 1252-9. PMID 11118815 DOI: 10.1016/S0891-5849(00)00419-6 |
0.583 |
|
| 2000 |
Montine TJ, Shinobu L, Montine KS, Roberts LJ, Kowall NW, Beal MF, Morrow JD. No difference in plasma or urinary F2-isoprostanes among patients with Huntington's disease or Alzheimer's disease and controls. Annals of Neurology. 48: 950. PMID 11117557 DOI: 10.1002/1531-8249(200012)48:6<950::Aid-Ana23>3.0.Co;2-F |
0.684 |
|
| 2000 |
Schulz JB, Dehmer T, Schöls L, Mende H, Hardt C, Vorgerd M, Bürk K, Matson W, Dichgans J, Beal MF, Bogdanov MB. Oxidative stress in patients with Friedreich ataxia. Neurology. 55: 1719-21. PMID 11113228 DOI: 10.1212/Wnl.55.11.1719 |
0.381 |
|
| 2000 |
Kuntz C, Kinoshita Y, Beal MF, Donehower LA, Morrison RS. Absence of p53: no effect in a transgenic mouse model of familial amyotrophic lateral sclerosis. Experimental Neurology. 165: 184-90. PMID 10964497 DOI: 10.1006/Exnr.2000.7464 |
0.349 |
|
| 2000 |
Albers DS, Beal MF. Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease. Journal of Neural Transmission. Supplementum. 59: 133-54. PMID 10961426 DOI: 10.1007/978-3-7091-6781-6_16 |
0.427 |
|
| 2000 |
Andreassen OA, Dedeoglu A, Klivenyi P, Beal MF, Bush AI. N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis. Neuroreport. 11: 2491-3. PMID 10943709 DOI: 10.1097/00001756-200008030-00029 |
0.656 |
|
| 2000 |
Andreassen OA, Ferrante RJ, Hughes DB, Klivenyi P, Dedeoglu A, Ona VO, Friedlander RM, Beal MF. Malonate and 3-nitropropionic acid neurotoxicity are reduced in transgenic mice expressing a caspase-1 dominant-negative mutant. Journal of Neurochemistry. 75: 847-52. PMID 10899963 DOI: 10.1046/J.1471-4159.2000.0750847.X |
0.661 |
|
| 2000 |
Manfredi G, Beal MF. The role of mitochondria in the pathogenesis of neurodegenerative diseases. Brain Pathology (Zurich, Switzerland). 10: 462-72. PMID 10885665 DOI: 10.1111/J.1750-3639.2000.Tb00278.X |
0.381 |
|
| 2000 |
Beal MF. Mitochondria and the pathogenesis of ALS. Brain : a Journal of Neurology. 123: 1291-2. PMID 10869044 DOI: 10.1093/Brain/123.7.1291 |
0.336 |
|
| 2000 |
Beal MF. Energetics in the pathogenesis of neurodegenerative diseases. Trends in Neurosciences. 23: 298-304. PMID 10856939 DOI: 10.1016/S0166-2236(00)01584-8 |
0.4 |
|
| 2000 |
Ferrante RJ, Andreassen OA, Jenkins BG, Dedeoglu A, Kuemmerle S, Kubilus JK, Kaddurah-Daouk R, Hersch SM, Beal MF. Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 4389-97. PMID 10844007 DOI: 10.1523/Jneurosci.20-12-04389.2000 |
0.535 |
|
| 2000 |
Beal MF. Limited-time exposure to mitochondrial toxins may lead to chronic progressive neurodegenerative diseases. Movement Disorders : Official Journal of the Movement Disorder Society. 15: 434-5. PMID 10830405 DOI: 10.1002/1531-8257(200005)15:3<434::Aid-Mds1002>3.0.Co;2-Q |
0.327 |
|
| 2000 |
Klivenyi P, Andreassen OA, Ferrante RJ, Lancelot E, Reif D, Beal MF. Inhibition of neuronal nitric oxide synthase protects against MPTP toxicity. Neuroreport. 11: 1265-8. PMID 10817604 DOI: 10.1097/00001756-200004270-00024 |
0.779 |
|
| 2000 |
Jenkins BG, Klivenyi P, Kustermann E, Andreassen OA, Ferrante RJ, Rosen BR, Beal MF. Nonlinear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington's disease mice. Journal of Neurochemistry. 74: 2108-19. PMID 10800956 DOI: 10.1046/J.1471-4159.2000.0742108.X |
0.664 |
|
| 2000 |
Andreassen OA, Ferrante RJ, Klivenyi P, Klein AM, Shinobu LA, Epstein CJ, Beal MF. Partial deficiency of manganese superoxide dismutase exacerbates a transgenic mouse model of amyotrophic lateral sclerosis. Annals of Neurology. 47: 447-55. PMID 10762155 DOI: 10.1002/1531-8249(200004)47:4<447::Aid-Ana7>3.0.Co;2-R |
0.811 |
|
| 2000 |
Malcon C, Kaddurah-Daouk R, Beal MF. Neuroprotective effects of creatine administration against NMDA and malonate toxicity. Brain Research. 860: 195-8. PMID 10727643 DOI: 10.1016/S0006-8993(00)02038-2 |
0.781 |
|
| 2000 |
Kowall NW, Hantraye P, Brouillet E, Beal MF, McKee AC, Ferrante RJ. MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons. Neuroreport. 11: 211-3. PMID 10683860 DOI: 10.1097/00001756-200001170-00041 |
0.549 |
|
| 2000 |
Simon DK, Mayeux R, Marder K, Kowall NW, Beal MF, Johns DR. Mitochondrial DNA mutations in complex I and tRNA genes in Parkinson's disease. Neurology. 54: 703-9. PMID 10680807 DOI: 10.1212/Wnl.54.3.703 |
0.412 |
|
| 2000 |
Albers DS, Augood SJ, Park LC, Browne SE, Martin DM, Adamson J, Hutton M, Standaert DG, Vonsattel JP, Gibson GE, Beal MF. Frontal lobe dysfunction in progressive supranuclear palsy: evidence for oxidative stress and mitochondrial impairment. Journal of Neurochemistry. 74: 878-81. PMID 10646541 DOI: 10.1046/J.1471-4159.2000.740878.X |
0.551 |
|
| 2000 |
Klivenyi P, Andreassen OA, Ferrante RJ, Dedeoglu A, Mueller G, Lancelot E, Bogdanov M, Andersen JK, Jiang D, Beal MF. Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 1-7. PMID 10627575 DOI: 10.1523/Jneurosci.20-01-00001.2000 |
0.806 |
|
| 2000 |
Ferrante RJ, Andreassen OA, Jenkins BG, Dedeoglu A, Kuemmerle S, Kubilus JK, Kaddurah-Daouk R, Hersch SM, Beal MF. Neuroprotective Effects of Creatine in a Transgenic Mouse Model of Huntington's Disease The Journal of Neuroscience. 20: 4389-4397. DOI: 10.1523/JNEUROSCI.20-12-04389.2000 |
0.427 |
|
| 2000 |
Park LC, Albers DS, Beal M, Gibson GE. Mitochondrial impairment in cerebellum from patients with progressive supranuclear palsy Neurobiology of Aging. 21: 79. DOI: 10.1016/S0197-4580(00)82577-4 |
0.313 |
|
| 2000 |
Gasparini L, Gouras GK, Wang R, Gross RS, Beal M, Greengard P, Xu H. Insulin-regulated β-amyloid protein trafficking: Stimulated secretion and reduced intracellular accumulation of Aβ in neuronal cell cultures Neurobiology of Aging. 21: 183. DOI: 10.1016/S0197-4580(00)82165-X |
0.688 |
|
| 2000 |
Kaddurah-Daouk R, Matthews R, Beal MF. Amyotrophic lateral sclerosis: Transgenic model and novel neuroprotective agent Neuroscience Research Communications. 26: 215-226. DOI: 10.1002/1520-6769(200005/06)26:3<215::Aid-Nrc9>3.0.Co;2-Z |
0.448 |
|
| 1999 |
Beal MF. Mitochondria, NO and neurodegeneration. Biochemical Society Symposium. 66: 43-54. PMID 10989656 DOI: 10.1042/Bss0660043 |
0.394 |
|
| 1999 |
Grünewald T, Beal MF. Bioenergetics in Huntington's disease. Annals of the New York Academy of Sciences. 893: 203-13. PMID 10672239 DOI: 10.1111/J.1749-6632.1999.Tb07827.X |
0.423 |
|
| 1999 |
Kuemmerle S, Gutekunst CA, Klein AM, Li XJ, Li SH, Beal MF, Hersch SM, Ferrante RJ. Huntington aggregates may not predict neuronal death in Huntington's disease. Annals of Neurology. 46: 842-9. PMID 10589536 DOI: 10.1002/1531-8249(199912)46:6<842::Aid-Ana6>3.0.Co;2-O |
0.351 |
|
| 1999 |
Grünewald T, Beal MF. NOS knockouts and neuroprotection. Nature Medicine. 5: 1354-5. PMID 10581072 DOI: 10.1038/70918 |
0.416 |
|
| 1999 |
Simon DK, Pulst SM, Sutton JP, Browne SE, Beal MF, Johns DR. Familial multisystem degeneration with parkinsonism associated with the 11778 mitochondrial DNA mutation. Neurology. 53: 1787-93. PMID 10563629 DOI: 10.1212/Wnl.53.8.1787 |
0.586 |
|
| 1999 |
Brouillet E, Condé F, Beal MF, Hantraye P. Replicating Huntington's disease phenotype in experimental animals. Progress in Neurobiology. 59: 427-68. PMID 10515664 DOI: 10.1016/S0301-0082(99)00005-2 |
0.608 |
|
| 1999 |
Polidori MC, Mecocci P, Browne SE, Senin U, Beal MF. Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex. Neuroscience Letters. 272: 53-6. PMID 10507541 DOI: 10.1016/S0304-3940(99)00578-9 |
0.645 |
|
| 1999 |
Cherubini A, Beal MF, Frei B. Black tea increases the resistance of human plasma to lipid peroxidation in vitro, but not ex vivo. Free Radical Biology & Medicine. 27: 381-7. PMID 10468212 DOI: 10.1016/S0891-5849(99)00064-7 |
0.462 |
|
| 1999 |
Dautry C, Condé F, Brouillet E, Mittoux V, Beal MF, Bloch G, Hantraye P. Serial 1H-NMR spectroscopy study of metabolic impairment in primates chronically treated with the succinate dehydrogenase inhibitor 3-nitropropionic acid. Neurobiology of Disease. 6: 259-68. PMID 10448053 DOI: 10.1006/Nbdi.1999.0244 |
0.588 |
|
| 1999 |
Albers DS, Augood SJ, Martin DM, Standaert DG, Vonsattel JP, Beal MF. Evidence for oxidative stress in the subthalamic nucleus in progressive supranuclear palsy. Journal of Neurochemistry. 73: 881-4. PMID 10428088 DOI: 10.1046/J.1471-4159.1999.0730881.X |
0.307 |
|
| 1999 |
Shults CW, Haas RH, Beal MF. A possible role of coenzyme Q10 in the etiology and treatment of Parkinson's disease. Biofactors (Oxford, England). 9: 267-72. PMID 10416040 DOI: 10.1002/Biof.5520090223 |
0.374 |
|
| 1999 |
Beal MF. Coenzyme Q10 administration and its potential for treatment of neurodegenerative diseases. Biofactors (Oxford, England). 9: 261-6. PMID 10416039 DOI: 10.1002/Biof.5520090222 |
0.437 |
|
| 1999 |
Lezza AM, Mecocci P, Cormio A, Beal MF, Cherubini A, Cantatore P, Senin U, Gadaleta MN. Mitochondrial DNA 4977 bp deletion and OH8dG levels correlate in the brain of aged subjects but not Alzheimer's disease patients. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 13: 1083-8. PMID 10336891 DOI: 10.1096/Fasebj.13.9.1083 |
0.623 |
|
| 1999 |
Matthews RT, Ferrante RJ, Klivenyi P, Yang L, Klein AM, Mueller G, Kaddurah-Daouk R, Beal MF. Creatine and cyclocreatine attenuate MPTP neurotoxicity. Experimental Neurology. 157: 142-9. PMID 10222117 DOI: 10.1006/Exnr.1999.7049 |
0.785 |
|
| 1999 |
Matthews RT, Klivenyi P, Mueller G, Yang L, Wermer M, Thomas CE, Beal MF. Novel free radical spin traps protect against malonate and MPTP neurotoxicity. Experimental Neurology. 157: 120-6. PMID 10222114 DOI: 10.1006/Exnr.1999.7045 |
0.757 |
|
| 1999 |
Klevenyi P, Andreassen O, Ferrante RJ, Schleicher JR, Friedlander RM, Beal MF. Transgenic mice expressing a dominant negative mutant interleukin-1beta converting enzyme show resistance to MPTP neurotoxicity. Neuroreport. 10: 635-8. PMID 10208603 DOI: 10.1097/00001756-199902250-00035 |
0.505 |
|
| 1999 |
Fiskum G, Murphy AN, Beal MF. Mitochondria in neurodegeneration: Acute ischemia and chronic neurodegenerative diseases Journal of Cerebral Blood Flow and Metabolism. 19: 351-369. PMID 10197505 DOI: 10.1097/00004647-199904000-00001 |
0.367 |
|
| 1999 |
Ferrante RJ, Hantraye P, Brouillet E, Beal MF. Increased nitrotyrosine immunoreactivity in substantia nigra neurons in MPTP treated baboons is blocked by inhibition of neuronal nitric oxide synthase. Brain Research. 823: 177-82. PMID 10095024 DOI: 10.1016/S0006-8993(99)01166-X |
0.651 |
|
| 1999 |
Klivenyi P, Ferrante RJ, Matthews RT, Bogdanov MB, Klein AM, Andreassen OA, Mueller G, Wermer M, Kaddurah-Daouk R, Beal MF. Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. Nature Medicine. 5: 347-50. PMID 10086395 DOI: 10.1038/6568 |
0.725 |
|
| 1999 |
Bogdanov MB, Ferrante RJ, Mueller G, Ramos LE, Martinou JC, Beal MF. Oxidative stress is attenuated in mice overexpressing BCL-2. Neuroscience Letters. 262: 33-6. PMID 10076866 DOI: 10.1016/S0304-3940(99)00047-6 |
0.569 |
|
| 1999 |
Browne SE, Ayata C, Huang PL, Moskowitz MA, Beal MF. The cerebral metabolic consequences of nitric oxide synthase deficiency: glucose utilization in endothelial and neuronal nitric oxide synthase null mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 19: 144-8. PMID 10027769 DOI: 10.1097/00004647-199902000-00005 |
0.554 |
|
| 1999 |
Ayoub IA, Lee EJ, Ogilvy CS, Beal MF, Maynard KI. Nicotinamide reduces infarction up to two hours after the onset of permanent focal cerebral ischemia in Wistar rats. Neuroscience Letters. 259: 21-4. PMID 10027546 DOI: 10.1016/S0304-3940(98)00881-7 |
0.315 |
|
| 1999 |
Browne SE, Ferrante RJ, Beal MF. Oxidative stress in Huntington's disease. Brain Pathology (Zurich, Switzerland). 9: 147-63. PMID 9989457 DOI: 10.1111/J.1750-3639.1999.Tb00216.X |
0.589 |
|
| 1999 |
Mecocci P, Fanó G, Fulle S, MacGarvey U, Shinobu L, Polidori MC, Cherubini A, Vecchiet J, Senin U, Beal MF. Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle. Free Radical Biology & Medicine. 26: 303-8. PMID 9895220 DOI: 10.1016/S0891-5849(98)00208-1 |
0.769 |
|
| 1999 |
Disatnik MH, Dhawan J, Yu Y, Beal MF, Whirl MM, Franco AA, Rando TA. Evidence of oxidative stress in mdx mouse muscle: studies of the pre-necrotic state. Journal of the Neurological Sciences. 161: 77-84. PMID 9879685 DOI: 10.1016/S0022-510X(98)00258-5 |
0.302 |
|
| 1999 |
LEZZA A, MECOCCI P, CORMIO A, BEAL MF, CHERUBINI A, CANTATORE P, SENIN U, GADALETA M. Area-Specific Differences in OH8dG and mtDNA4977 Levels in Alzheimer Disease Patients and Aged Controls Journal of Anti-Aging Medicine. 2: 209-216. DOI: 10.1089/Rej.1.1999.2.209 |
0.613 |
|
| 1998 |
Davis RE, Miller S, Herrnstadt C, Ghosh SS, Fahy E, Shinobu LA, Galasko D, Thal LJ, Beal MF, Howell N, Parker WD. Retraction. Proceedings of the National Academy of Sciences of the United States of America. 95: 12069. PMID 16578857 |
0.626 |
|
| 1998 |
Schulz JB, Weller M, Matthews RT, Heneka MT, Groscurth P, Martinou JC, Lommatzsch J, von Coelln R, Wüllner U, Löschmann PA, Beal MF, Dichgans J, Klockgether T. Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia. Cell Death and Differentiation. 5: 847-57. PMID 10203688 DOI: 10.1038/sj.cdd.4400420 |
0.423 |
|
| 1998 |
Lancelot E, Beal MF. Glutamate toxicity in chronic neurodegenerative disease. Progress in Brain Research. 116: 331-47. PMID 9932386 DOI: 10.1016/S0079-6123(08)60446-X |
0.634 |
|
| 1998 |
Bogdanov MB, Ferrante RJ, Kuemmerle S, Klivenyi P, Beal MF. Increased vulnerability to 3-nitropropionic acid in an animal model of Huntington's disease. Journal of Neurochemistry. 71: 2642-4. PMID 9832167 DOI: 10.1046/J.1471-4159.1998.71062642.X |
0.626 |
|
| 1998 |
Klivenyi P, Beal MF, Ferrante RJ, Andreassen OA, Wermer M, Chin MR, Bonventre JV. Mice deficient in group IV cytosolic phospholipase A2 are resistant to MPTP neurotoxicity. Journal of Neurochemistry. 71: 2634-7. PMID 9832165 DOI: 10.1046/J.1471-4159.1998.71062634.X |
0.65 |
|
| 1998 |
Yang L, Matthews RT, Schulz JB, Klockgether T, Liao AW, Martinou JC, Penney JB, Hyman BT, Beal MF. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 8145-52. PMID 9763461 DOI: 10.1523/Jneurosci.18-20-08145.1998 |
0.704 |
|
| 1998 |
Andreassen OA, Ferrante RJ, Beal MF, Jørgensen HA. Oral Dyskinesias and striatal lesions in rats after long-term co-treatment with haloperidol and 3-nitropropionic acid. Neuroscience. 87: 639-48. PMID 9758230 DOI: 10.1016/S0306-4522(98)00160-2 |
0.369 |
|
| 1998 |
Beal MF. Excitotoxicity and nitric oxide in Parkinson's disease pathogenesis Annals of Neurology. 44. PMID 9749581 DOI: 10.1002/Ana.410440716 |
0.439 |
|
| 1998 |
Polidori MC, Frei B, Cherubini A, Nelles G, Rordorf G, Keaney JF, Schwamm L, Mecocci P, Koroshetz WJ, Beal MF. Increased plasma levels of lipid hydroperoxides in patients with ischemic stroke. Free Radical Biology & Medicine. 25: 561-7. PMID 9741593 DOI: 10.1016/S0891-5849(98)00085-9 |
0.576 |
|
| 1998 |
Bogdanov MB, Ramos LE, Xu Z, Beal MF. Elevated 'hydroxyl radical' generation in vivo in an animal model of amyotrophic lateral sclerosis Journal of Neurochemistry. 71: 1321-1324. PMID 9721759 DOI: 10.1046/J.1471-4159.1998.71031321.X |
0.383 |
|
| 1998 |
Klivenyi P, Matthews RT, Wermer M, Yang L, MacGarvey U, Becker DA, Natero R, Beal MF. Azulenyl nitrone spin traps protect against MPTP neurotoxicity. Experimental Neurology. 152: 163-6. PMID 9682023 DOI: 10.1006/Exnr.1998.6824 |
0.7 |
|
| 1998 |
Matthews RT, Yang L, Browne S, Baik M, Beal MF. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proceedings of the National Academy of Sciences of the United States of America. 95: 8892-7. PMID 9671775 DOI: 10.1073/Pnas.95.15.8892 |
0.658 |
|
| 1998 |
Browne SE, Bowling AC, Baik MJ, Gurney M, Brown RH, Beal MF. Metabolic dysfunction in familial, but not sporadic, amyotrophic lateral sclerosis. Journal of Neurochemistry. 71: 281-7. PMID 9648876 DOI: 10.1046/J.1471-4159.1998.71010281.X |
0.67 |
|
| 1998 |
Smith MA, Sayre LM, Anderson VE, Harris PL, Beal MF, Kowall N, Perry G. Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 46: 731-5. PMID 9603784 DOI: 10.1177/002215549804600605 |
0.481 |
|
| 1998 |
Beal MF, Matthews RT, Tieleman A, Shults CW. Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice. Brain Research. 783: 109-14. PMID 9479058 DOI: 10.1016/S0006-8993(97)01192-X |
0.332 |
|
| 1998 |
Matthews RT, Yang L, Jenkins BG, Ferrante RJ, Rosen BR, Kaddurah-Daouk R, Beal MF. Neuroprotective Effects of Creatine and Cyclocreatine in Animal Models of Huntington’s Disease The Journal of Neuroscience. 18: 156-163. DOI: 10.1523/Jneurosci.18-01-00156.1998 |
0.631 |
|
| 1998 |
Klein AM, Ferrante RJ, Kowall NW, Matthews RT, McKee AC, Kaddurak-Daouk R, Beal MF. CREATINE AND CYCLOCREATINE ATTENUATE MPTP NEUROTOXICITY Journal of Neuropathology and Experimental Neurology. 57: 510. DOI: 10.1097/00005072-199805000-00183 |
0.353 |
|
| 1997 |
Beal MF, Ferrante RJ, Browne SE, Matthews RT, Kowall NW, Brown RH. Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis. Annals of Neurology. 42: 644-54. PMID 9382477 DOI: 10.1002/ana.410420416 |
0.481 |
|
| 1997 |
Ferrante RJ, Browne SE, Shinobu LA, Bowling AC, Baik MJ, MacGarvey U, Kowall NW, Brown RH, Beal MF. Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis. Journal of Neurochemistry. 69: 2064-74. PMID 9349552 DOI: 10.1046/J.1471-4159.1997.69052064.X |
0.804 |
|
| 1997 |
Beal MF. New techniques for investigating mitochondrial DNA in neurodegenerative diseases Neurology. 49: 907-908. PMID 9339665 DOI: 10.1212/Wnl.49.4.907 |
0.348 |
|
| 1997 |
Matthews RT, Beal MF, Fallon J, Fedorchak K, Huang PL, Fishman MC, Hyman BT. MPP+ induced substantia nigra degeneration is attenuated in nNOS knockout mice. Neurobiology of Disease. 4: 114-21. PMID 9331901 DOI: 10.1006/Nbdi.1997.0141 |
0.427 |
|
| 1997 |
Schulz JB, Matthews RT, Klockgether T, Dichgans J, Beal MF. The role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenerative diseases. Molecular and Cellular Biochemistry. 174: 193-7. PMID 9309687 DOI: 10.1023/A:1006852306789 |
0.542 |
|
| 1997 |
Ferrante RJ, Shinobu LA, Schulz JB, Matthews RT, Thomas CE, Kowall NW, Gurney ME, Beal MF. Increased 3-nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation. Annals of Neurology. 42: 326-34. PMID 9307254 DOI: 10.1002/Ana.410420309 |
0.773 |
|
| 1997 |
Ayata C, Ayata G, Hara H, Matthews RT, Beal MF, Ferrante RJ, Endres M, Kim A, Christie RH, Waeber C, Huang PL, Hyman BT, Moskowitz MA. Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 6908-17. PMID 9278526 DOI: 10.1523/Jneurosci.17-18-06908.1997 |
0.377 |
|
| 1997 |
Mecocci P, Beal MF, Cecchetti R, Polidori MC, Cherubini A, Chionne F, Avellini L, Romano G, Senin U. Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 31: 53-64. PMID 9271005 DOI: 10.1007/Bf02815160 |
0.625 |
|
| 1997 |
Beal MF, Matthews RT. Coenzyme Q10 in the central nervous system and its potential usefulness in the treatment of neurodegenerative diseases. Molecular Aspects of Medicine. 18: S169-79. PMID 9266519 DOI: 10.1016/S0098-2997(97)00024-1 |
0.318 |
|
| 1997 |
Bruijn LI, Beal MF, Becher MW, Schulz JB, Wong PC, Price DL, Cleveland DW. Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant. Proceedings of the National Academy of Sciences of the United States of America. 94: 7606-11. PMID 9207139 DOI: 10.1073/Pnas.94.14.7606 |
0.464 |
|
| 1997 |
Matthews RT, Ferrante RJ, Jenkins BG, Browne SE, Goetz K, Berger S, Chen IY, Beal MF. Iodoacetate produces striatal excitotoxic lesions. Journal of Neurochemistry. 69: 285-9. PMID 9202321 DOI: 10.1046/J.1471-4159.1997.69010285.X |
0.532 |
|
| 1997 |
Browne SE, Bowling AC, MacGarvey U, Baik MJ, Berger SC, Muqit MM, Bird ED, Beal MF. Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia. Annals of Neurology. 41: 646-53. PMID 9153527 DOI: 10.1002/ana.410410514 |
0.637 |
|
| 1997 |
Schulz JB, Panahian N, Chen YI, Beal MF, Moskowitz MA, Rosen BR, Jenkins BG. Facilitation of postischemic reperfusion with alpha-PBN: assessment using NMR and Doppler flow techniques. The American Journal of Physiology. 272: H1986-95. PMID 9139987 DOI: 10.1152/AJPHEART.1997.272.4.H1986 |
0.347 |
|
| 1997 |
Fallon J, Matthews RT, Hyman BT, Beal MF. MPP+ produces progressive neuronal degeneration which is mediated by oxidative stress. Experimental Neurology. 144: 193-8. PMID 9126170 DOI: 10.1006/Exnr.1997.6416 |
0.406 |
|
| 1997 |
Ferrante RJ, Schulz JB, Kowall NW, Beal MF. Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra. Brain Research. 753: 157-62. PMID 9125443 DOI: 10.1016/S0006-8993(97)00008-5 |
0.502 |
|
| 1997 |
Davis RE, Miller S, Herrnstadt C, Ghosh SS, Fahy E, Shinobu LA, Galasko D, Thal LJ, Beal MF, Howell N, Parker WD. Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 94: 4526-31. PMID 9114023 DOI: 10.1073/Pnas.94.9.4526 |
0.716 |
|
| 1997 |
Matthews RT, Yang L, Beal MF. S-Methylthiocitrulline, a neuronal nitric oxide synthase inhibitor, protects against malonate and MPTP neurotoxicity. Experimental Neurology. 143: 282-6. PMID 9056390 DOI: 10.1006/Exnr.1996.6406 |
0.651 |
|
| 1997 |
Koroshetz WJ, Jenkins BG, Rosen BR, Beal MF. Energy metabolism defects in Huntington's disease and effects of coenzyme Q10. Annals of Neurology. 41: 160-5. PMID 9029064 DOI: 10.1002/Ana.410410206 |
0.334 |
|
| 1997 |
Beal MF. Mitochondria, free radicals, and neurodegeneration. Current Opinion in Neurobiology. 6: 661-6. PMID 8937831 DOI: 10.1016/S0959-4388(96)80100-0 |
0.388 |
|
| 1997 |
Beal MF. Oxidative Damage in Neurodegenerative Diseases The Neuroscientist. 3: 21-27. DOI: 10.1177/107385849700300112 |
0.409 |
|
| 1997 |
Neil WK, Shinobu LA, Beal MF, Ferrante RJ. OXIDATIVE INJURY IN THE SPINAL CORDS OF TRANSGENIC MICE EXPRESSING MUTANT HUMAN SUPEROXIDE DISMUTASE Journal of Neuropathology and Experimental Neurology. 56: 611. DOI: 10.1097/00005072-199705000-00172 |
0.705 |
|
| 1996 |
Galpern WR, Matthews RT, Beal MF, Isacson O. NGF attenuates 3-nitrotyrosine formation in a 3-NP model of Huntington's disease. Neuroreport. 7: 2639-42. PMID 8981438 DOI: 10.1097/00001756-199611040-00046 |
0.335 |
|
| 1996 |
Schulz JB, Henshaw DR, MacGarvey U, Beal MF. Involvement of oxidative stress in 3-nitropropionic acid neurotoxicity. Neurochemistry International. 29: 167-71. PMID 8837046 DOI: 10.1016/0197-0186(95)00122-0 |
0.475 |
|
| 1996 |
Hantraye P, Brouillet E, Ferrante R, Palfi S, Dolan R, Matthews RT, Beal MF. Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nature Medicine. 2: 1017-21. PMID 8782460 DOI: 10.1038/nm0996-1017 |
0.614 |
|
| 1996 |
Vécsei L, Beal MF. Huntington's disease, behavioral disturbances, and kynurenines: preclinical findings and therapeutic perspectives. Biological Psychiatry. 39: 1061-3. PMID 8780845 DOI: 10.1016/0006-3223(95)00377-0 |
0.307 |
|
| 1996 |
Matthews RT, Beal MF. Increased 3-nitrotyrosine in brains of Apo E-deficient mice. Brain Research. 718: 181-4. PMID 8773783 DOI: 10.1016/0006-8993(95)01576-0 |
0.343 |
|
| 1996 |
Mecocci P, Cherubini A, Beal MF, Cecchetti R, Chionne F, Polidori MC, Romano G, Senin U. Altered mitochondrial membrane fluidity in AD brain. Neuroscience Letters. 207: 129-32. PMID 8731438 DOI: 10.1016/0304-3940(96)12509-X |
0.601 |
|
| 1996 |
Kirschner PB, Jenkins BG, Schulz JB, Finkelstein SP, Matthews RT, Rosen BR, Beal MF. NGF, BDNF and NT-5, but not NT-3 protect against MPP+ toxicity and oxidative stress in neonatal animals. Brain Research. 713: 178-85. PMID 8724989 DOI: 10.1016/0006-8993(95)01513-2 |
0.48 |
|
| 1996 |
Smith MA, Perry G, Richey PL, Sayre LM, Anderson VE, Beal MF, Kowall N. Oxidative damage in Alzheimer's. Nature. 382: 120-1. PMID 8700201 DOI: 10.1038/382120B0 |
0.354 |
|
| 1996 |
Galpern WR, Frim DM, Tatter SB, Altar CA, Beal MF, Isacson O. Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP+ rat model of substantia nigra degeneration. Cell Transplantation. 5: 225-32. PMID 8689033 DOI: 10.1016/0963-6897(95)02030-6 |
0.367 |
|
| 1996 |
Schulz JB, Matthews RT, Henshaw DR, Beal MF. Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases. Neuroscience. 71: 1043-8. PMID 8684608 DOI: 10.1016/0306-4522(95)00527-7 |
0.469 |
|
| 1996 |
Reaume AG, Elliott JL, Hoffman EK, Kowall NW, Ferrante RJ, Siwek DF, Wilcox HM, Flood DG, Beal MF, Brown RH, Scott RW, Snider WD. Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury. Nature Genetics. 13: 43-7. PMID 8673102 DOI: 10.1038/Ng0596-43 |
0.34 |
|
| 1996 |
Schulz JB, Huang PL, Matthews RT, Passov D, Fishman MC, Beal MF. Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice. Journal of Neurochemistry. 67: 430-3. PMID 8667023 DOI: 10.1046/J.1471-4159.1996.67010430.X |
0.542 |
|
| 1996 |
Palfi S, Ferrante RJ, Brouillet E, Beal MF, Dolan R, Guyot MC, Peschanski M, Hantraye P. Chronic 3-nitropropionic acid treatment in baboons replicates the cognitive and motor deficits of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 3019-25. PMID 8622131 DOI: 10.1523/Jneurosci.16-09-03019.1996 |
0.594 |
|
| 1996 |
Jenkins BG, Brouillet E, Chen YC, Storey E, Schulz JB, Kirschner P, Beal MF, Rosen BR. Non-invasive neurochemical analysis of focal excitotoxic lesions in models of neurodegenerative illness using spectroscopic imaging. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 16: 450-61. PMID 8621749 DOI: 10.1097/00004647-199605000-00011 |
0.714 |
|
| 1996 |
Kowall NW, Beal MF, Brown RH, Beckman JS, Volicer L, Ferrante RJ. LOCALIZATION OF MULTIPLE HISTOCHEMICAL MARKERS OF OXIDATIVE INJURY IN PROJECTION NEURONS IN ALZHEIMER CORTEX Journal of Neuropathology and Experimental Neurology. 55: 618. DOI: 10.1097/00005072-199605000-00064 |
0.308 |
|
| 1995 |
Schulz JB, Matthews RT, Beal MF. Role of nitric oxide in neurodegenerative diseases. Current Opinion in Neurology. 8: 480-6. PMID 8845936 DOI: 10.1097/00019052-199512000-00016 |
0.442 |
|
| 1995 |
Beal MF. Neurochemistry and toxin models in Huntington's disease. Current Opinion in Neurology. 7: 542-7. PMID 7866587 DOI: 10.1097/00019052-199412000-00012 |
0.445 |
|
| 1995 |
Kirschner PB, Henshaw R, Weise J, Trubetskoy V, Finklestein S, Schulz JB, Beal MF. Basic fibroblast growth factor protects against excitotoxicity and chemical hypoxia in both neonatal and adult rats. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 15: 619-23. PMID 7790410 DOI: 10.1038/Jcbfm.1995.76 |
0.463 |
|
| 1995 |
Schulz JB, Henshaw DR, Matthews RT, Beal MF. Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity. Experimental Neurology. 132: 279-83. PMID 7789466 DOI: 10.1016/0014-4886(95)90033-0 |
0.509 |
|
| 1995 |
Bowling AC, Barkowski EE, McKenna-Yasek D, Sapp P, Horvitz HR, Beal MF, Brown RH. Superoxide dismutase concentration and activity in familial amyotrophic lateral sclerosis. Journal of Neurochemistry. 64: 2366-9. PMID 7722523 DOI: 10.1046/J.1471-4159.1995.64052366.X |
0.493 |
|
| 1995 |
Beal MF. Aging, energy, and oxidative stress in neurodegenerative diseases Annals of Neurology. 38: 357-366. PMID 7668820 DOI: 10.1002/ana.410380304 |
0.314 |
|
| 1995 |
Brouillet E, Hantraye P, Ferrante RJ, Dolan R, Leroy-Willig A, Kowall NW, Beal MF. Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates. Proceedings of the National Academy of Sciences of the United States of America. 92: 7105-9. PMID 7624378 DOI: 10.1073/Pnas.92.15.7105 |
0.583 |
|
| 1995 |
Beal MF, Ferrante RJ, Henshaw R, Matthews RT, Chan PH, Kowall NW, Epstein CJ, Schulz JB. 3-Nitropropionic acid neurotoxicity is attenuated in copper/zinc superoxide dismutase transgenic mice. Journal of Neurochemistry. 65: 919-22. PMID 7616254 |
0.451 |
|
| 1995 |
Schulz JB, Matthews RT, Jenkins BG, Brar P, Beal MF. Improved therapeutic window for treatment of histotoxic hypoxia with a free radical spin trap. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 15: 948-52. PMID 7593355 DOI: 10.1038/Jcbfm.1995.120 |
0.474 |
|
| 1995 |
Aronin N, Chase K, Young C, Sapp E, Schwarz C, Matta N, Kornreich R, Lanwehrmeyer B, Bird E, Beal MF, Vonsattel JP, Smith T, Carraway R, Boyce FM, Young AB, et al. CAG expansion affects the expression of mutant huntingtin in the Huntington's disease brain Neuron. 15: 1193-1201. PMID 7576661 DOI: 10.1016/0896-6273(95)90106-X |
0.325 |
|
| 1995 |
Schulz JB, Henshaw DR, Siwek D, Jenkins BG, Ferrante RJ, Cipolloni PB, Kowall NW, Rosen BR, Beal MF. Involvement of free radicals in excitotoxicity in vivo. Journal of Neurochemistry. 64: 2239-47. PMID 7536809 DOI: 10.1046/J.1471-4159.1995.64052239.X |
0.497 |
|
| 1995 |
Schulz JB, Matthews RT, Muqit MM, Browne SE, Beal MF. Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice. Journal of Neurochemistry. 64: 936-9. PMID 7530297 DOI: 10.1046/J.1471-4159.1995.64020936.X |
0.673 |
|
| 1995 |
Schulz JB, Beal MF. Neuroprotective effects of free radical scavengers and energy repletion in animal models of neurodegenerative disease. Annals of the New York Academy of Sciences. 765: 100-10; discussion 1. PMID 7486598 DOI: 10.1111/J.1749-6632.1995.Tb16565.X |
0.489 |
|
| 1995 |
Bowling AC, Beal MF. Bioenergetic and oxidative stress in neurodegenerative diseases. Life Sciences. 56: 1151-71. PMID 7475893 DOI: 10.1016/0024-3205(95)00055-B |
0.596 |
|
| 1995 |
Kowall N, Ferrante R, Robert Brown JS, Beal MF. INTRACISTERNAL INFUSION OF SUPEROXIDE DISMUTASE-1 (SOD1) ANTISENSE OLIGODEOXYNUCLEOTIDE CAUSES ANTERIOR HORN CELL DEGENERATION IN VIVO Journal of Neuropathology and Experimental Neurology. 54: 417. DOI: 10.1097/00005072-199505000-00040 |
0.314 |
|
| 1994 |
Henshaw R, Jenkins BG, Schulz JB, Ferrante RJ, Kowall NW, Rosen BR, Beal MF. Malonate produces striatal lesions by indirect NMDA receptor activation. Brain Research. 647: 161-6. PMID 8069700 DOI: 10.1016/0006-8993(94)91412-5 |
0.483 |
|
| 1994 |
Beal MF, Henshaw DR, Jenkins BG, Rosen BR, Schulz JB. Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate. Annals of Neurology. 36: 882-8. PMID 7998775 DOI: 10.1002/Ana.410360613 |
0.514 |
|
| 1994 |
Mecocci P, MacGarvey U, Beal MF. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Annals of Neurology. 36: 747-51. PMID 7979220 DOI: 10.1002/Ana.410360510 |
0.473 |
|
| 1994 |
Mutisya EM, Bowling AC, Beal MF. Cortical cytochrome oxidase activity is reduced in Alzheimer's disease. Journal of Neurochemistry. 63: 2179-84. PMID 7964738 |
0.494 |
|
| 1994 |
Schulz JB, Beal MF. Mitochondrial dysfunction in movement disorders. Current Opinion in Neurology. 7: 333-9. PMID 7952242 |
0.486 |
|
| 1994 |
Esteban J, Rosen DR, Bowling AC, Sapp P, McKenna-Yasek D, O'Regan JP, Beal MF, Horvitz HR, Brown RH. Identification of two novel mutations and a new polymorphism in the gene for Cu/Zn superoxide dismutase in patients with amyotrophic lateral sclerosis. Human Molecular Genetics. 3: 997-8. PMID 7951252 DOI: 10.1093/Hmg/3.6.997 |
0.468 |
|
| 1994 |
Schulz JB, Henshaw DR, Jenkins BG, Ferrante RJ, Kowall NW, Rosen BR, Beal MF. 3-Acetylpyridine produces age-dependent excitotoxic lesions in rat striatum. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 14: 1024-9. PMID 7929644 DOI: 10.1038/Jcbfm.1994.134 |
0.477 |
|
| 1994 |
Storey E, Cipolloni PB, Ferrante RJ, Kowall NW, Beal MF. Movement disorder following excitotoxin lesions in primates. Neuroreport. 5: 1259-61. PMID 7919178 |
0.435 |
|
| 1994 |
Corral-Debrinski M, Horton T, Lott MT, Shoffner JM, McKee AC, Beal MF, Graham BH, Wallace DC. Marked changes in mitochondrial DNA deletion levels in Alzheimer brains. Genomics. 23: 471-6. PMID 7835898 DOI: 10.1006/Geno.1994.1525 |
0.302 |
|
| 1994 |
Brouillet E, Henshaw DR, Schulz JB, Beal MF. Aminooxyacetic acid striatal lesions attenuated by 1,3-butanediol and coenzyme Q10. Neuroscience Letters. 177: 58-62. PMID 7824183 DOI: 10.1016/0304-3940(94)90044-2 |
0.649 |
|
| 1994 |
Beal MF. Energy, oxidative damage, and Alzheimer's disease: Clues to the underlying puzzle Neurobiology of Aging. 15: 171-174. PMID 7700446 DOI: 10.1016/0197-4580(94)90198-8 |
0.341 |
|
| 1994 |
Browne SE, Beal MF. Oxidative damage and mitochondrial dysfunction in neurodegenerative diseases. Biochemical Society Transactions. 22: 1002-6. PMID 7698395 |
0.498 |
|
| 1994 |
Brouillet E, Hyman BT, Jenkins BG, Henshaw DR, Schulz JB, Sodhi P, Rosen BR, Beal MF. Systemic or local administration of azide produces striatal lesions by an energy impairment-induced excitotoxic mechanism. Experimental Neurology. 129: 175-82. PMID 7525331 DOI: 10.1006/Exnr.1994.1159 |
0.614 |
|
| 1993 |
Brouillet E, Beal MF. NMDA antagonists partially protect against MPTP induced neurotoxicity in mice. Neuroreport. 4: 387-90. PMID 8499594 DOI: 10.1097/00001756-199304000-00011 |
0.595 |
|
| 1993 |
Brouillet EP, Shinobu L, McGarvey U, Hochberg F, Beal MF. Manganese injection into the rat striatum produces excitotoxic lesions by impairing energy metabolism. Experimental Neurology. 120: 89-94. PMID 8477830 DOI: 10.1006/exnr.1993.1042 |
0.774 |
|
| 1993 |
Bowling AC, Mutisya EM, Walker LC, Price DL, Cork LC, Beal MF. Age-dependent impairment of mitochondrial function in primate brain. Journal of Neurochemistry. 60: 1964-7. PMID 8473911 DOI: 10.1111/J.1471-4159.1993.Tb13430.X |
0.449 |
|
| 1993 |
Nozaki K, Finklestein SP, Beal MF. Basic fibroblast growth factor protects against hypoxia-ischemia and NMDA neurotoxicity in neonatal rats. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 13: 221-8. PMID 8436614 DOI: 10.1038/Jcbfm.1993.27 |
0.316 |
|
| 1993 |
Ferrante RJ, Kowall NW, Cipolloni PB, Storey E, Beal MF. Excitotoxin lesions in primates as a model for Huntington's disease: histopathologic and neurochemical characterization. Experimental Neurology. 119: 46-71. PMID 8432351 DOI: 10.1006/exnr.1993.1006 |
0.508 |
|
| 1993 |
Brouillet E, Jenkins BG, Hyman BT, Ferrante RJ, Kowall NW, Srivastava R, Roy DS, Rosen BR, Beal MF. Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid. Journal of Neurochemistry. 60: 356-9. PMID 8417157 DOI: 10.1111/J.1471-4159.1993.Tb05859.X |
0.58 |
|
| 1993 |
Bowling AC, Schulz JB, Brown RH, Beal MF. Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis. Journal of Neurochemistry. 61: 2322-5. PMID 8245985 DOI: 10.1111/J.1471-4159.1993.Tb07478.X |
0.61 |
|
| 1993 |
Mecocci P, MacGarvey U, Kaufman AE, Koontz D, Shoffner JM, Wallace DC, Beal MF. Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Annals of Neurology. 34: 609-16. PMID 8215249 DOI: 10.1002/Ana.410340416 |
0.511 |
|
| 1993 |
Shoffner JM, Brown MD, Torroni A, Lott MT, Cabell MF, Mirra SS, Beal MF, Yang CC, Gearing M, Salvo R. Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients. Genomics. 17: 171-84. PMID 8104867 DOI: 10.1006/Geno.1993.1299 |
0.34 |
|
| 1993 |
Srivastava R, Brouillet E, Beal MF, Storey E, Hyman BT. Blockade of 1-methyl-4-phenylpyridinium ion (MPP+) nigral toxicity in the rat by prior decortication or MK-801 treatment: a stereological estimate of neuronal loss. Neurobiology of Aging. 14: 295-301. PMID 8103573 DOI: 10.1016/0197-4580(93)90114-Q |
0.689 |
|
| 1993 |
Storey E, Beal MF. Neurochemical substrates of rigidity and chorea in Huntington's disease. Brain : a Journal of Neurology. 116: 1201-22. PMID 7693298 |
0.486 |
|
| 1993 |
Beal MF, Brouillet E, Jenkins BG, Ferrante RJ, Kowall NW, Miller JM, Storey E, Srivastava R, Rosen BR, Hyman BT. Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 4181-92. PMID 7692009 |
0.655 |
|
| 1993 |
Beal MF, Brouillet E, Jenkins B, Henshaw R, Rosen B, Hyman BT. Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate. Journal of Neurochemistry. 61: 1147-50. PMID 7689641 DOI: 10.1111/J.1471-4159.1993.Tb03633.X |
0.612 |
|
| 1993 |
Beal MF, Hyman BT, Koroshetz W. Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? Trends in Neurosciences. 16: 125-31. PMID 7682343 DOI: 10.1016/0166-2236(93)90117-5 |
0.416 |
|
| 1993 |
Beal M, Brouillet E, Jenkins B, Ferrante R, Kowall N, Miller J, Storey E, Srivastava R, Rosen B, Hyman B. Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid The Journal of Neuroscience. 13: 4181-4192. DOI: 10.1523/Jneurosci.13-10-04181.1993 |
0.788 |
|
| 1992 |
Vécsei L, Miller J, MacGarvey U, Beal MF. Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain. Brain Research Bulletin. 28: 233-8. PMID 1596743 DOI: 10.1016/0361-9230(92)90184-Y |
0.689 |
|
| 1992 |
Storey E, Hyman BT, Jenkins B, Brouillet E, Miller JM, Rosen BR, Beal MF. 1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism. Journal of Neurochemistry. 58: 1975-8. PMID 1560246 DOI: 10.1111/J.1471-4159.1992.Tb10080.X |
0.702 |
|
| 1992 |
Beal MF. Role of excitotoxicity in human neurological disease Current Opinion in Neurobiology. 2: 657-662. PMID 1422123 DOI: 10.1016/0960-9822(92)90039-D |
0.319 |
|
| 1992 |
Martin JB, Beal MF. Huntington's disease and neurotoxins. Annals of the New York Academy of Sciences. 648: 169-75. PMID 1386201 DOI: 10.1111/J.1749-6632.1992.Tb24535.X |
0.324 |
|
| 1992 |
Beal MF, Matson WR, Storey E, Milbury P, Ryan EA, Ogawa T, Bird ED. Kynurenic acid concentrations are reduced in Huntington's disease cerebral cortex. Journal of the Neurological Sciences. 108: 80-7. PMID 1385624 DOI: 10.1016/0022-510X(92)90191-M |
0.56 |
|
| 1992 |
Beal MF. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Annals of Neurology. 31: 119-30. PMID 1349466 DOI: 10.1002/ANA.410310202 |
0.322 |
|
| 1992 |
Storey E, Kowall NW, Finn SF, Mazurek MF, Beal MF. The cortical lesion of Huntington's disease: further neurochemical characterization, and reproduction of some of the histological and neurochemical features by N-methyl-D-aspartate lesions of rat cortex. Annals of Neurology. 32: 526-34. PMID 1280937 DOI: 10.1002/Ana.410320408 |
0.549 |
|
| 1991 |
Finn SF, Swartz KJ, Beal MF. 2-Chloroadenosine attenuates NMDA, kainate, and quisqualate toxicity. Neuroscience Letters. 126: 191-4. PMID 1922933 DOI: 10.1016/0304-3940(91)90551-4 |
0.315 |
|
| 1991 |
Finn SF, Hyman BT, Storey E, Miller JM, Beal MF. Effects of aging on quinolinic acid lesions in rat striatum. Brain Research. 562: 276-80. PMID 1837750 DOI: 10.1016/0006-8993(91)90631-5 |
0.512 |
|
| 1991 |
Beal MF, Swartz KJ, Hyman BT, Storey E, Finn SF, Koroshetz W. Aminooxyacetic acid results in excitotoxin lesions by a novel indirect mechanism. Journal of Neurochemistry. 57: 1068-73. PMID 1830613 DOI: 10.1111/J.1471-4159.1991.Tb08258.X |
0.559 |
|
| 1991 |
Uemura Y, Kowall NW, Beal MF. Global ischemia induces NMDA receptor-mediated c-fos expression in neurons resistant to injury in gerbil hippocampus. Brain Research. 542: 343-7. PMID 1827611 DOI: 10.1016/0006-8993(91)91589-S |
0.468 |
|
| 1991 |
Heyes MP, Swartz KJ, Markey SP, Beal MF. Regional brain and cerebrospinal fluid quinolinic acid concentrations in Huntington's disease. Neuroscience Letters. 122: 265-9. PMID 1827518 DOI: 10.1016/0304-3940(91)90874-S |
0.33 |
|
| 1991 |
Uemura Y, Miller JM, Matson WR, Beal MF. Neurochemical analysis of focal ischemia in rats. Stroke; a Journal of Cerebral Circulation. 22: 1548-53. PMID 1720576 |
0.422 |
|
| 1991 |
Beal MF, Walker LC, Storey E, Segar L, Price DL, Cork LC. Neurotransmitters in neocortex of aged rhesus monkeys. Neurobiology of Aging. 12: 407-12. PMID 1685218 DOI: 10.1016/0197-4580(91)90065-R |
0.48 |
|
| 1990 |
Beal MF, Matson WR, Swartz KJ, Gamache PH, Bird ED. Kynurenine pathway measurements in Huntington's disease striatum: evidence for reduced formation of kynurenic acid. Journal of Neurochemistry. 55: 1327-39. PMID 2144582 DOI: 10.1111/J.1471-4159.1990.Tb03143.X |
0.335 |
|
| 1990 |
Freese A, DiFiglia M, Koroshetz WJ, Beal MF, Martin JB. Characterization and mechanism of glutamate neurotoxicity in primary striatal cultures. Brain Research. 521: 254-64. PMID 1976413 DOI: 10.1016/0006-8993(90)91550-Z |
0.304 |
|
| 1990 |
Beal MF. Somatostatin in neurodegenerative illnesses Metabolism. 39: 116-119. PMID 1976204 DOI: 10.1016/0026-0495(90)90226-3 |
0.384 |
|
| 1990 |
Uemura Y, Kowall NW, Beal MF. Selective sparing of NADPH-diaphorase-somatostatin-neuropeptide Y neurons in ischemic gerbil striatum. Annals of Neurology. 27: 620-5. PMID 1972876 DOI: 10.1002/Ana.410270606 |
0.536 |
|
| 1990 |
Beal MF, MacGarvey U, Swartz KJ. Galanin immunoreactivity is increased in the nucleus basalis of Meynert in Alzheimer's disease. Annals of Neurology. 28: 157-61. PMID 1699471 DOI: 10.1002/Ana.410280207 |
0.333 |
|
| 1990 |
Beal MF, Kowall NW, Swartz KJ, Ferrante RJ. Homocysteic acid lesions in rat striatum spare somatostatin-neuropeptide Y (NADPH-diaphorase) neurons. Neuroscience Letters. 108: 36-42. PMID 1689475 DOI: 10.1016/0304-3940(90)90702-B |
0.331 |
|
| 1989 |
Beal MF, Kowall NW, Swartz KJ, Ferrante RJ, Martin JB. Differential sparing of somatostatin-neuropeptide Y and cholinergic neurons following striatal excitotoxin lesions. Synapse (New York, N.Y.). 3: 38-47. PMID 2563916 DOI: 10.1002/Syn.890030106 |
0.33 |
|
| 1989 |
Clevens RA, Beal MF. Substance P-like immunoreactivity in brains with pathological features of Parkinson's and Alzheimer's diseases. Brain Research. 486: 387-90. PMID 2471578 DOI: 10.1016/0006-8993(89)90529-5 |
0.336 |
|
| 1989 |
Kowall NW, Beal MF. Galanin-like immunoreactivity is present in human substantia innominata and in senile plaques in Alzheimer's disease. Neuroscience Letters. 98: 118-23. PMID 2469045 DOI: 10.1016/0304-3940(89)90384-4 |
0.355 |
|
| 1988 |
Beal MF, Clevens RA, Mazurek MF. Somatostatin and neuropeptide Y immunoreactivity in Parkinson's disease dementia with Alzheimer's changes. Synapse (New York, N.Y.). 2: 463-7. PMID 2903567 DOI: 10.1002/Syn.890020415 |
0.345 |
|
| 1988 |
Beal MF, Mazurek MF, Ellison DW, Swartz KJ, McGarvey U, Bird ED, Martin JB. Somatostatin and neuropeptide Y concentrations in pathologically graded cases of Huntington's disease. Annals of Neurology. 23: 562-9. PMID 2900622 DOI: 10.1002/Ana.410230606 |
0.335 |
|
| 1988 |
Kowall NW, Beal MF. Cortical somatostatin, neuropeptide Y, and NADPH diaphorase neurons: normal anatomy and alterations in Alzheimer's disease. Annals of Neurology. 23: 105-14. PMID 2897822 DOI: 10.1002/Ana.410230202 |
0.353 |
|
| 1988 |
Beal MF, Clevens RA, Chattha GK, MacGarvey UM, Mazurek MF, Gabriel SM. Galanin-like immunoreactivity is unchanged in Alzheimer's disease and Parkinson's disease dementia cerebral cortex. Journal of Neurochemistry. 51: 1935-41. PMID 2460590 DOI: 10.1111/J.1471-4159.1988.Tb01181.X |
0.377 |
|
| 1988 |
Beal MF, Swartz KJ, Finn SF, Bird ED, Martin JB. Amino acid and neuropeptide neurotransmitters in Huntington's disease cerebellum. Brain Research. 454: 393-6. PMID 2457409 DOI: 10.1016/0006-8993(88)90844-X |
0.341 |
|
| 1988 |
Beal MF, Ellison DW, Mazurek MF, Swartz KJ, Malloy JR, Bird ED, Martin JB. A detailed examination of substance P in pathologically graded cases of Huntington's disease. Journal of the Neurological Sciences. 84: 51-61. PMID 2452859 DOI: 10.1016/0022-510X(88)90173-6 |
0.347 |
|
| 1988 |
Ellison DW, Clevens RA, Beal MF. Cortical amino acids in Brains with pathological features of Parkinson's and Alzheimer's diseases Neurochemical Pathology. 8: 53-62. DOI: 10.1007/Bf03160135 |
0.334 |
|
| 1987 |
Chattha GK, Beal MF. Effect of cysteamine on somatostatin and neuropeptide Y in rat striatum and cortical synaptosomes. Brain Research. 401: 359-64. PMID 3815102 DOI: 10.1016/0006-8993(87)91421-1 |
0.315 |
|
| 1987 |
Ellison DW, Beal MF, Martin JB. Phosphoethanolamine and ethanolamine are decreased in Alzheimer's disease and Huntington's disease. Brain Research. 417: 389-92. PMID 2958109 DOI: 10.1016/0006-8993(87)90471-9 |
0.383 |
|
| 1987 |
Ferrante RJ, Beal MF, Kowall NW, Richardson EP, Martin JB. Sparing of acetylcholinesterase-containing striatal neurons in Huntington's disease. Brain Research. 411: 162-6. PMID 2955849 DOI: 10.1016/0006-8993(87)90694-9 |
0.352 |
|
| 1987 |
Ferrante RJ, Kowall NW, Beal MF, Martin JB, Bird ED, Richardson EP. Morphologic and histochemical characteristics of a spared subset of striatal neurons in Huntington's disease. Journal of Neuropathology and Experimental Neurology. 46: 12-27. PMID 2947977 DOI: 10.1097/00005072-198701000-00002 |
0.346 |
|
| 1987 |
Beal MF, Mazurek MF, McKee MA. The regional distribution of somatostatin and neuropeptide Y in control and Alzheimer's disease striatum. Neuroscience Letters. 79: 201-6. PMID 2890123 DOI: 10.1016/0304-3940(87)90697-5 |
0.314 |
|
| 1986 |
Beal MF, Mazurek MF, Martin JB. Somatostatin immunoreactivity is reduced in Parkinson's disease dementia with Alzheimer's changes. Brain Research. 397: 386-8. PMID 3801878 DOI: 10.1016/0006-8993(86)90644-X |
0.326 |
|
| 1986 |
Beal MF, Mazurek MF, Svendsen CN, Bird ED, Martin JB. Widespread reduction of somatostatin-like immunoreactivity in the cerebral cortex in Alzheimer's disease. Annals of Neurology. 20: 489-95. PMID 3789664 DOI: 10.1002/Ana.410200408 |
0.344 |
|
| 1986 |
Beal MF, Mazurek MF, Chattha GK, Svendsen CN, Bird ED, Martin JB. Neuropeptide Y immunoreactivity is reduced in cerebral cortex in Alzheimer's disease. Annals of Neurology. 20: 282-8. PMID 3767313 DOI: 10.1002/Ana.410200303 |
0.34 |
|
| 1986 |
Beal MF, Martin JB. Neuropeptides in neurological disease. Annals of Neurology. 20: 547-65. PMID 2947536 DOI: 10.1002/Ana.410200502 |
0.365 |
|
| 1986 |
Ellison DW, Beal MF, Mazurek MF, Bird ED, Martin JB. A postmortem study of amino acid neurotransmitters in Alzheimer's disease. Annals of Neurology. 20: 616-21. PMID 2878639 DOI: 10.1002/Ana.410200510 |
0.333 |
|
| 1986 |
Beal MF, Benoit R, Mazurek MF, Bird ED, Martin JB. Somatostatin-28(1-12)-like immunoreactivity is reduced in Alzheimer's disease cerebral cortex. Brain Research. 368: 380-3. PMID 2870772 DOI: 10.1016/0006-8993(86)90586-X |
0.324 |
|
| 1985 |
Beal MF, Domesick VB, Martin JB. Effects of lesions in the amygdala and periventricular hypothalamus on striatal somatostatin-like immunoreactivity. Brain Research. 330: 309-16. PMID 3986546 DOI: 10.1016/0006-8993(85)90690-0 |
0.3 |
|
| 1985 |
Kowall NW, Beal MF, Ferrante RJ, Martin JB. Topography of nicotinamide adenine dinucleotide phosphate-diaphorase staining neurons in rat striatum. Neuroscience Letters. 59: 61-6. PMID 2931630 DOI: 10.1016/0304-3940(85)90215-0 |
0.313 |
|
| 1985 |
Beal MF, Marshall PE, Burd GD, Landis DM, Martin JB. Excitotoxin lesions do not mimic the alteration of somatostatin in Huntington's disease. Brain Research. 361: 135-45. PMID 2867808 DOI: 10.1016/0006-8993(85)91283-1 |
0.365 |
|
| 1985 |
Beal MF, Benoit R, Bird ED, Martin JB. Immunoreactive somatostatin-28(1-12) is increased in Huntington's disease. Neuroscience Letters. 56: 377-80. PMID 2862613 DOI: 10.1016/0304-3940(85)90272-1 |
0.325 |
|
| 1984 |
Beal MF, Martin JB. Effects of neuroleptic drugs on brain somatostatin-like-immunoreactivity. Neuroscience Letters. 47: 125-30. PMID 6146954 DOI: 10.1016/0304-3940(84)90417-8 |
0.311 |
|
| 1983 |
Beal MF, Martin JB. Effects of lesions on somatostatin-like immunoreactivity in the rat striatum. Brain Research. 266: 67-73. PMID 6133592 DOI: 10.1016/0006-8993(83)91309-4 |
0.33 |
|
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