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Brian M. Necela, Ph.D. - Publications

Affiliations: 
2000 Medical University of South Carolina, Charleston, SC, United States 
Area:
Molecular Biology, Pharmacology, Biochemistry
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Vasmatzis G, Wang X, Smadbeck JB, Murphy SJ, Geiersbach KB, Johnson SH, Gaitatzes AG, Asmann YW, Kosari F, Borad MJ, Serie DJ, McLaughlin SA, Kachergus JM, Necela BM, Aubrey Thompson E. Chromoanasynthesis is a common mechanism that leads to ERBB2 amplifications in a cohort of early stage HER2 breast cancer samples. Bmc Cancer. 18: 738. PMID 30005627 DOI: 10.1186/S12885-018-4594-0  0.339
2018 Norton N, Fox N, McCarl CA, Tenner KS, Ballman K, Erskine CL, Necela BM, Northfelt D, Tan WW, Calfa C, Pegram M, Colon-Otero G, Perez EA, Clynes R, Knutson KL. Generation of HER2-specific antibody immunity during trastuzumab adjuvant therapy associates with reduced relapse in resected HER2 breast cancer. Breast Cancer Research : Bcr. 20: 52. PMID 29898752 DOI: 10.1186/S13058-018-0989-8  0.311
2017 Serie DJ, Crook JE, Necela BM, Axenfeld BC, Dockter TJ, Colon-Otero G, Perez EA, Thompson EA, Norton N. Breast Cancer Clinical Trial of Chemotherapy and Trastuzumab: Potential Tool to Identify Cardiac Modifying Variants of Dilated Cardiomyopathy. Journal of Cardiovascular Development and Disease. 4. PMID 29367538 DOI: 10.3390/Jcdd4020006  0.349
2017 Davila JI, Starr JS, Attia S, Wang C, Knudson RA, Necela BM, Sarangi V, Sun Z, Ren Y, Casler JD, Menke DM, Oliver GR, Joseph RW, Copland JA, Parker AS, et al. Comprehensive Genomic Profiling of a Rare Thyroid Follicular Dendritic Cell Sarcoma. Rare Tumors. 9: 6834. PMID 28975018 DOI: 10.4081/Rt.2017.6834  0.35
2017 Serie DJ, Crook JE, Necela BM, Dockter TJ, Wang X, Asmann YW, Fairweather D, Bruno KA, Colon-Otero G, Perez EA, Thompson EA, Norton N. Genome-wide association study of cardiotoxicity in the NCCTG N9831 (Alliance) adjuvant trastuzumab trial. Pharmacogenetics and Genomics. PMID 28763429 DOI: 10.1097/Fpc.0000000000000302  0.33
2017 Necela BM, Axenfeld BC, Serie DJ, Kachergus JM, Perez EA, Thompson EA, Norton N. The antineoplastic drug, trastuzumab, dysregulates metabolism in iPSC-derived cardiomyocytes. Clinical and Translational Medicine. 6: 5. PMID 28101782 DOI: 10.1186/S40169-016-0133-2  0.34
2017 Perez EA, Ballman KV, Mashadi-Hossein A, Tenner KS, Kachergus JM, Norton N, Necela BM, Carr JM, Ferree S, Perou CM, Baehner F, Cheang MC, Thompson EA. Intrinsic Subtype and Therapeutic Response Among HER2-Positive Breaty st Tumors from the NCCTG (Alliance) N9831 Trial. Journal of the National Cancer Institute. 109. PMID 27794124 DOI: 10.1093/Jnci/Djw207  0.346
2017 Chumsri S, Serie DJ, Necela BM, Kachergus JM, Axenfeld BC, Demirkan G, Meredith G, Ross PM, Kharkia A, Piazza E, Mashadi-Hossein A, Warren S, McLaughlin SA, Beechem J, Geiss G, et al. Abstract 3377: Simultaneous analysis of the mutational landscape and RNA and protein expression profile of HER2-positive breast cancer using 3D BiologyTM Cancer Research. 77: 3377-3377. DOI: 10.1158/1538-7445.Am2017-3377  0.345
2016 Holst F, Hoivik EA, Gibson WJ, Taylor-Weiner A, Schumacher SE, Asmann YW, Grossmann P, Trovik J, Necela BM, Thompson EA, Meyerson M, Beroukhim R, Salvesen HB, Cherniack AD. Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth. Scientific Reports. 6: 25521. PMID 27160768 DOI: 10.1038/Srep25521  0.378
2016 Norton N, Advani PP, Serie DJ, Geiger XJ, Necela BM, Axenfeld BC, Kachergus JM, Feathers RW, Carr JM, Crook JE, Moreno-Aspitia A, Anastasiadis PZ, Perez EA, Thompson EA. Assessment of Tumor Heterogeneity, as Evidenced by Gene Expression Profiles, Pathway Activation, and Gene Copy Number, in Patients with Multifocal Invasive Lobular Breast Tumors. Plos One. 11: e0153411. PMID 27078887 DOI: 10.1371/Journal.Pone.0153411  0.406
2016 Perez E, Ballman K, Mashadi-Hossein A, Tenner K, Kachergus J, Norton N, Necela B, Carr J, Ferree S, Perou C, Cheang M, Thompson E. Abstract P3-07-04: Intrinsic subtype and therapeutic response among early stage HER2-positive breast tumors from the North Central cancer treatment group (Alliance) N9831 trial Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P3-07-04  0.376
2016 Chumsri S, Necela B, Ordentlich P, Advani P, Moreno-Aspitia A, McLaughlin S, Geiger X, McDonough M, Vallow L, Perez E, Thompson E. Abstract P2-04-02: Immunomodulatory effects of entinostat on PD-L1 and MHC class I and II in different subtypes of breast cancer Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P2-04-02  0.357
2015 Necela BM, Crozier JA, Andorfer CA, Lewis-Tuffin L, Kachergus JM, Geiger XJ, Kalari KR, Serie DJ, Sun Z, Aspita AM, O'Shannessy DJ, Maltzman JD, McCullough AE, Pockaj BA, Cunliffe HE, et al. Folate receptor-α (FOLR1) expression and function in triple negative tumors. Plos One. 10: e0122209. PMID 25816016 DOI: 10.1371/Journal.Pone.0122209  0.439
2015 Asmann YW, Wang C, Necela BM, Chen X, Kocher JA, Maurer MJ, Habermann TM, Slager SL, Feldman AL, Novak AJ, Cerhan JR, Perez EA, Thompson EA. Abstract P6-07-03: An exhaustive algorithm for detecting copy number aberrations and large structural variants in whole-genome mate-pair sequencing data Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P6-07-03  0.33
2014 Smallridge RC, Chindris AM, Asmann YW, Casler JD, Serie DJ, Reddi HV, Cradic KW, Rivera M, Grebe SK, Necela BM, Eberhardt NL, Carr JM, McIver B, Copland JA, Aubrey Thompson E. RNA sequencing identifies multiple fusion transcripts, differentially expressed genes, and reduced expression of immune function genes in BRAF (V600E) mutant vs BRAF wild-type papillary thyroid carcinoma. The Journal of Clinical Endocrinology and Metabolism. 99: E338-47. PMID 24297791 DOI: 10.1210/Jc.2013-2792  0.369
2014 Asmann YW, Wang C, Necela BM, Chen X, Kocher JA, Maurer MJ, Habermann TM, Slager SL, Feldman AL, Dogan A, Novak A, Cerhan JR, Perez EA, Thompson EA. An exhaustive algorithm for detecting copy number aberrations and large structural variants in whole-genome, mate-pair sequencing data. Journal of Clinical Oncology. 32. DOI: 10.1200/Jco.2014.32.15_Suppl.E22171  0.335
2014 Thompson EA, Necela BM, Carr JM, Kachergus JM, Serie D, Kalari KR, Asmann YW, Perez EA. Identification and targeting of M-phase progression downstream of HER2 in trastuzumab-sensitive and -resistant breast cancer cell lines. Journal of Clinical Oncology. 32: 612-612. DOI: 10.1200/Jco.2014.32.15_Suppl.612  0.354
2014 Davila JI, Starr J, Attia S, Wang C, Wang X, Necela B, John C, Menke D, Sarangi V, Oliver G, Joseph R, Copland J, Parker A, Thompson EA, Smallridge R, et al. Abstract 1894: Extensive genomic profiling of a rare extranodal-follicular dendritic cell sarcoma: Implications for future individualized therapy Cancer Research. 74: 1894-1894. DOI: 10.1158/1538-7445.Am2014-1894  0.42
2013 Norton N, Sun Z, Asmann YW, Serie DJ, Necela BM, Bhagwate A, Jen J, Eckloff BW, Kalari KR, Thompson KJ, Carr JM, Kachergus JM, Geiger XJ, Perez EA, Thompson EA. Gene expression, single nucleotide variant and fusion transcript discovery in archival material from breast tumors. Plos One. 8: e81925. PMID 24278466 DOI: 10.1371/Journal.Pone.0081925  0.355
2013 Kalari KR, Necela BM, Tang X, Thompson KJ, Lau M, Eckel-Passow JE, Kachergus JM, Anderson SK, Sun Z, Baheti S, Carr JM, Baker TR, Barman P, Radisky DC, Joseph RW, et al. An integrated model of the transcriptome of HER2-positive breast cancer. Plos One. 8: e79298. PMID 24223926 DOI: 10.1371/Journal.Pone.0079298  0.419
2013 Kalari KR, Necela BM, Tang X, Thompson KJ, Lau M, Eckel-Passow JE, Kachergus JM, Anderson SK, Sun Z, Baheti S, Carr JM, Baker TR, Barman P, Radisky DC, Joseph RW, et al. Clustering of genes uniquely expressed in HER2 tumors. Plos One. DOI: 10.1371/Journal.Pone.0079298.G005  0.33
2013 Crozier JA, Necela BM, Thompson EA, Geiger X, Moreno-Aspitia A, McCullough AE, Pockaj BA, Cunliffe H, Sun Z, Kalari KR, Kachergus JM, O'Shannessy DJ, Maltzman JD, Ballman KV, Andorfer CA, et al. Increased expression of folate receptor-α (FRA) in triple-negative breast cancer: A potential therapeutic target. Journal of Clinical Oncology. 31: 1037-1037. DOI: 10.1200/Jco.2013.31.15_Suppl.1037  0.402
2013 Norton N, Perez EA, Asmann YW, Carr JM, Necela BM, Kachergus JM, Jen J, Eckloff BW, Thompson EA. Abstract 2005: Analysis of gene expression and copy number variation in breast tumors using both sequencing and hybridization-based platforms. Cancer Research. 73: 2005-2005. DOI: 10.1158/1538-7445.Am2013-2005  0.381
2012 Kalari KR, Rossell D, Necela BM, Asmann YW, Nair A, Baheti S, Kachergus JM, Younkin CS, Baker T, Carr JM, Tang X, Walsh MP, Chai HS, Sun Z, Hart SN, et al. Deep Sequence Analysis of Non-Small Cell Lung Cancer: Integrated Analysis of Gene Expression, Alternative Splicing, and Single Nucleotide Variations in Lung Adenocarcinomas with and without Oncogenic KRAS Mutations. Frontiers in Oncology. 2: 12. PMID 22655260 DOI: 10.3389/Fonc.2012.00012  0.37
2012 Asmann YW, Necela BM, Kalari KR, Hossain A, Baker TR, Carr JM, Davis C, Getz JE, Hostetter G, Li X, McLaughlin SA, Radisky DC, Schroth GP, Cunliffe HE, Perez EA, et al. Detection of redundant fusion transcripts as biomarkers or disease-specific therapeutic targets in breast cancer. Cancer Research. 72: 1921-8. PMID 22496456 DOI: 10.1158/0008-5472.Can-11-3142  0.418
2012 Kalari KR, Chai H, Asmann YW, Tang X, Rossell D, Baheti S, Nair A, Baker TR, Necela BM, Carr JM, Hart SN, Sun Z, Kachergus JM, Younkin CS, Kocher JA, et al. Abstract 4926: Modeling the transcriptome landscape of HER2+ breast cancer Cancer Research. 72: 4926-4926. DOI: 10.1158/1538-7445.Am2012-4926  0.442
2011 Asmann YW, Hossain A, Necela BM, Middha S, Kalari KR, Sun Z, Chai HS, Williamson DW, Radisky D, Schroth GP, Kocher JP, Perez EA, Thompson EA. A novel bioinformatics pipeline for identification and characterization of fusion transcripts in breast cancer and normal cell lines. Nucleic Acids Research. 39: e100. PMID 21622959 DOI: 10.1093/Nar/Gkr362  0.365
2011 Andorfer CA, Necela BM, Thompson EA, Perez EA. MicroRNA signatures: clinical biomarkers for the diagnosis and treatment of breast cancer. Trends in Molecular Medicine. 17: 313-9. PMID 21376668 DOI: 10.1016/J.Molmed.2011.01.006  0.325
2011 Thompson EA, Asmann YW, Necela BM, Kalari KR, Williamson DW, Carr JM, Baker TR, Schroth GP, Kocher JA, Perez EA. Abstract LB-276: Fusion transcripts in breast cancer cell lines and tumors Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-276  0.428
2011 Thompson E, Asmann Y, Necela B, Andorfer C, Cunliffe H, Hossain A, Getz J, Hostetter G, Schroth G, Perez E. P3-06-02: Identification of Redundant, Tumor Subtype Specific Fusion Transcripts in Primary Breast Tumors. Cancer Research. 71. DOI: 10.1158/0008-5472.Sabcs11-P3-06-02  0.417
2010 Lewis-Tuffin LJ, Rodriguez F, Giannini C, Scheithauer B, Necela BM, Sarkaria JN, Anastasiadis PZ. Misregulated E-cadherin expression associated with an aggressive brain tumor phenotype. Plos One. 5: e13665. PMID 21060868 DOI: 10.1371/Journal.Pone.0013665  0.34
2008 Necela BM, Su W, Thompson EA. Peroxisome proliferator-activated receptor gamma down-regulates follistatin in intestinal epithelial cells through SP1. The Journal of Biological Chemistry. 283: 29784-94. PMID 18768463 DOI: 10.1074/Jbc.M804481200  0.332
2008 Su W, Necela BM, Fujiwara K, Kurakata S, Murray NR, Fields AP, Thompson EA. The high affinity peroxisome proliferator-activated receptor-gamma agonist RS5444 inhibits both initiation and progression of colon tumors in azoxymethane-treated mice. International Journal of Cancer. Journal International Du Cancer. 123: 991-7. PMID 18546290 DOI: 10.1002/Ijc.23640  0.304
2007 Bush CR, Havens JM, Necela BM, Su W, Chen L, Yanagisawa M, Anastasiadis PZ, Guerra R, Luxon BA, Thompson EA. Functional genomic analysis reveals cross-talk between peroxisome proliferator-activated receptor gamma and calcium signaling in human colorectal cancer cells. The Journal of Biological Chemistry. 282: 23387-401. PMID 17565986 DOI: 10.1074/Jbc.M702708200  0.359
2007 Su W, Bush CR, Necela BM, Calcagno SR, Murray NR, Fields AP, Thompson EA. Differential expression, distribution, and function of PPAR-gamma in the proximal and distal colon. Physiological Genomics. 30: 342-53. PMID 17519361 DOI: 10.1152/Physiolgenomics.00042.2007  0.338
2006 Chen L, Bush CR, Necela BM, Su W, Yanagisawa M, Anastasiadis PZ, Fields AP, Thompson EA. RS5444, a novel PPARgamma agonist, regulates aspects of the differentiated phenotype in nontransformed intestinal epithelial cells. Molecular and Cellular Endocrinology. 251: 17-32. PMID 16574311 DOI: 10.1016/J.Mce.2006.02.006  0.323
2004 Necela BM, Cidlowski JA. A single amino acid change in the first zinc finger of the DNA binding domain of the glucocorticoid receptor regulates differential promoter selectivity. The Journal of Biological Chemistry. 279: 39279-88. PMID 15220338 DOI: 10.1074/Jbc.M405489200  0.318
2003 Necela BM, Cidlowski JA. Development of a flow cytometric assay to study glucocorticoid receptor-mediated gene activation in living cells. Steroids. 68: 341-50. PMID 12787895 DOI: 10.1016/S0039-128X(03)00032-1  0.325
2002 Pollenz RS, Necela B, Marks-Sojka K. Analysis of rainbow trout Ah receptor protein isoforms in cell culture reveals conservation of function in Ah receptor-mediated signal transduction. Biochemical Pharmacology. 64: 49-60. PMID 12106605 DOI: 10.1016/S0006-2952(02)01061-4  0.347
1998 Pollenz RS, Necela B. Characterization of two continuous cell lines derived from Oncorhynchus mykiss for models of aryl-hydrocarbon-receptor-mediated signal transduction: Direct comparison to the mammalian Hepa-1c1c7 cell line Aquatic Toxicology. 41: 31-49. DOI: 10.1016/S0166-445X(97)00073-8  0.321
1996 Pollenz RS, Sullivan HR, Holmes J, Necela B, Peterson RE. Isolation and expression of cDNAs from rainbow trout (Oncorhynchus mykiss) that encode two novel basic helix-loop-Helix/PER-ARNT-SIM (bHLH/PAS) proteins with distinct functions in the presence of the aryl hydrocarbon receptor. Evidence for alternative mRNA splicing and dominant negative activity in the bHLH/PAS family. The Journal of Biological Chemistry. 271: 30886-96. PMID 8940073 DOI: 10.1074/Jbc.271.48.30886  0.334
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