Joan Massague - Publications

Affiliations: 
Weill Cornell Medical College, New York, NY, United States 
Area:
Oncology, Cell Biology, Biostatistics Biology

143 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Valiente M, Van Swearingen AED, Anders CK, Bairoch A, Boire A, Bos PD, Cittelly DM, Erez N, Ferraro GB, Fukumura D, Gril B, Herlyn M, Holmen SL, Jain RK, Joyce JA, ... ... Massague J, et al. Brain Metastasis Cell Lines Panel: a public resource of organotropic cell lines. Cancer Research. PMID 32641416 DOI: 10.1158/0008-5472.Can-20-0291  0.48
2020 Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, Campbell K, Cano A, Casanova J, Christofori G, Dedhar S, Derynck R, Ford HL, Fuxe J, García de Herreros A, et al. Guidelines and definitions for research on epithelial-mesenchymal transition. Nature Reviews. Molecular Cell Biology. PMID 32300252 DOI: 10.1038/S41580-020-0237-9  0.96
2020 Ganesh K, Basnet H, Kaygusuz Y, Laughney A, He L, Sharma R, O'Rourke K, Reuter V, Huang Y, Masilionis I, Turkekul M, Er E, Manova-Todorova K, Saltz L, Weiser M, ... ... Massague J, et al. Abstract A12: L1CAM defines the regenerative origin of metastasis initiating cells in colorectal cancer Cancer Research. 80. DOI: 10.1158/1538-7445.Camodels2020-A12  0.4
2016 Chen Q, Boire A, Jin X, Valiente M, Er EE, Lopez-Soto A, Jacob LS, Patwa R, Shah H, Xu K, Cross JR, Massagué J. Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature. 533: 493-8. PMID 27225120 DOI: 10.1038/Nature18268  1
2016 Malladi S, Macalinao DG, Jin X, He L, Basnet H, Zou Y, de Stanchina E, Massagué J. Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT. Cell. 165: 45-60. PMID 27015306 DOI: 10.1016/J.Cell.2016.02.025  1
2016 David CJ, Huang YH, Chen M, Su J, Zou Y, Bardeesy N, Iacobuzio-Donahue CA, Massagué J. TGF-β Tumor Suppression through a Lethal EMT. Cell. PMID 26898331 DOI: 10.1016/J.Cell.2016.01.009  1
2015 Jacob LS, Vanharanta S, Obenauf AC, Pirun M, Viale A, Socci ND, Massagué J. Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations. Cancer Research. 75: 3713-9. PMID 26208905 DOI: 10.1158/0008-5472.Can-15-0562  1
2015 Obenauf AC, Zou Y, Ji AL, Vanharanta S, Shu W, Shi H, Kong X, Bosenberg MC, Wiesner T, Rosen N, Lo RS, Massagué J. Therapy-induced tumour secretomes promote resistance and tumour progression. Nature. 520: 368-72. PMID 25807485 DOI: 10.1038/Nature14336  1
2014 Sevenich L, Bowman RL, Mason SD, Quail DF, Rapaport F, Elie BT, Brogi E, Brastianos PK, Hahn WC, Holsinger LJ, Massagué J, Leslie CS, Joyce JA. Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S. Nature Cell Biology. 16: 876-88. PMID 25086747 DOI: 10.1038/Ncb3011  1
2014 Vanharanta S, Marney CB, Shu W, Valiente M, Zou Y, Mele A, Darnell RB, Massagué J. Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer. Elife. 3. PMID 24898756 DOI: 10.7554/Elife.02734  1
2014 Morales M, Arenas EJ, Urosevic J, Guiu M, Fernández E, Planet E, Fenwick RB, Fernández-Ruiz S, Salvatella X, Reverter D, Carracedo A, Massagué J, Gomis RR. RARRES3 suppresses breast cancer lung metastasis by regulating adhesion and differentiation. Embo Molecular Medicine. 6: 865-81. PMID 24867881 DOI: 10.15252/Emmm.201303675  1
2014 Valiente M, Obenauf AC, Jin X, Chen Q, Zhang XH, Lee DJ, Chaft JE, Kris MG, Huse JT, Brogi E, Massagué J. Serpins promote cancer cell survival and vascular co-option in brain metastasis. Cell. 156: 1002-16. PMID 24581498 DOI: 10.1016/J.Cell.2014.01.040  1
2014 Acharyya S, Matrisian L, Welch DR, Massagué J. Invasion and Metastasis The Molecular Basis of Cancer: Fourth Edition. 269-284.e2. DOI: 10.1016/B978-1-4557-4066-6.00018-4  1
2013 Stankic M, Pavlovic S, Chin Y, Brogi E, Padua D, Norton L, Massagué J, Benezra R. TGF-β-Id1 signaling opposes Twist1 and promotes metastatic colonization via a mesenchymal-to-epithelial transition. Cell Reports. 5: 1228-42. PMID 24332369 DOI: 10.1016/J.Celrep.2013.11.014  1
2013 Zhang XH, Jin X, Malladi S, Zou Y, Wen YH, Brogi E, Smid M, Foekens JA, Massagué J. Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell. 154: 1060-73. PMID 23993096 DOI: 10.1016/J.Cell.2013.07.036  1
2013 Hynes NE, Ingham PW, Lim WA, Marshall CJ, Massagué J, Pawson T. Signalling change: signal transduction through the decades. Nature Reviews. Molecular Cell Biology. 14: 393-8. PMID 23636498 DOI: 10.1038/Nrm3581  1
2012 Acharyya S, Oskarsson T, Vanharanta S, Malladi S, Kim J, Morris PG, Manova-Todorova K, Leversha M, Hogg N, Seshan VE, Norton L, Brogi E, Massagué J. A CXCL1 paracrine network links cancer chemoresistance and metastasis. Cell. 150: 165-78. PMID 22770218 DOI: 10.1016/J.Cell.2012.04.042  1
2012 Massagué J, Xi Q. TGF-β control of stem cell differentiation genes. Febs Letters. 586: 1953-8. PMID 22710171 DOI: 10.1016/J.Febslet.2012.03.023  1
2011 Xi Q, Wang Z, Zaromytidou AI, Zhang XH, Chow-Tsang LF, Liu JX, Kim H, Barlas A, Manova-Todorova K, Kaartinen V, Studer L, Mark W, Patel DJ, Massagué J. A poised chromatin platform for TGF-β access to master regulators. Cell. 147: 1511-24. PMID 22196728 DOI: 10.1016/J.Cell.2011.11.032  1
2011 Lu X, Mu E, Wei Y, Riethdorf S, Yang Q, Yuan M, Yan J, Hua Y, Tiede BJ, Lu X, Haffty BG, Pantel K, Massagué J, Kang Y. VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors. Cancer Cell. 20: 701-14. PMID 22137794 DOI: 10.1016/J.Ccr.2011.11.002  0.96
2011 Oskarsson T, Acharyya S, Zhang XH, Vanharanta S, Tavazoie SF, Morris PG, Downey RJ, Manova-Todorova K, Brogi E, Massagué J. Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs. Nature Medicine. 17: 867-74. PMID 21706029 DOI: 10.1038/Nm.2379  1
2011 Schultz N, Marenstein DR, De Angelis DA, Wang WQ, Nelander S, Jacobsen A, Marks DS, Massagué J, Sander C. Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2. Silence. 2: 3. PMID 21401928 DOI: 10.1186/1758-907X-2-3  1
2011 Png KJ, Yoshida M, Zhang XH, Shu W, Lee H, Rimner A, Chan TA, Comen E, Andrade VP, Kim SW, King TA, Hudis CA, Norton L, Hicks J, Massagué J, et al. MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer. Genes & Development. 25: 226-31. PMID 21289068 DOI: 10.1101/Gad.1974211  1
2011 Dorn DC, He W, Massague J, Moore MAS. TIF1γ Knockdown Enhances Hematopoietic Stem Cell Self Renewal with Preferential Myeloid Differentiation and Delayed Erythropoiesis Blood. 118: 4829-4829. DOI: 10.1182/Blood.V118.21.4829.4829  0.4
2010 Bos PD, Nguyen DX, Massagué J. Modeling metastasis in the mouse. Current Opinion in Pharmacology. 10: 571-7. PMID 20598638 DOI: 10.1016/J.Coph.2010.06.003  1
2010 Oskarsson T, Nagorny P, Krauss IJ, Perez L, Mandal M, Yang G, Ouerfelli O, Xiao D, Moore MA, Massagué J, Danishefsky SJ. Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog. Journal of the American Chemical Society. 132: 3224-8. PMID 20155906 DOI: 10.1021/Ja9101503  1
2010 Lu X, Yang Q, Yuan M, Mu E, Reiss M, Haffty B, Massagué J, Kang Y. Abstract 5763: VCAM1 mediates aggressive bone metastasis outbreak from tumor dormancy by engaging α4β1-positive osteoclast progenitor cells Cancer Research. 70: 5763-5763. DOI: 10.1158/1538-7445.Am10-5763  0.96
2009 Kim MY, Oskarsson T, Acharyya S, Nguyen DX, Zhang XH, Norton L, Massagué J. Tumor self-seeding by circulating cancer cells. Cell. 139: 1315-26. PMID 20064377 DOI: 10.1016/J.Cell.2009.11.025  1
2009 Alarcón C, Zaromytidou AI, Xi Q, Gao S, Yu J, Fujisawa S, Barlas A, Miller AN, Manova-Todorova K, Macias MJ, Sapkota G, Pan D, Massagué J. Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell. 139: 757-69. PMID 19914168 DOI: 10.1016/J.Cell.2009.09.035  1
2009 Lu X, Wang Q, Hu G, Van Poznak C, Fleisher M, Reiss M, Massagué J, Kang Y. ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. Genes & Development. 23: 1882-94. PMID 19608765 DOI: 10.1101/Gad.1824809  0.96
2009 Nguyen DX, Chiang AC, Zhang XH, Kim JY, Kris MG, Ladanyi M, Gerald WL, Massagué J. WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell. 138: 51-62. PMID 19576624 DOI: 10.1016/J.Cell.2009.04.030  1
2009 Bos PD, Zhang XH, Nadal C, Shu W, Gomis RR, Nguyen DX, Minn AJ, van de Vijver MJ, Gerald WL, Foekens JA, Massagué J. Genes that mediate breast cancer metastasis to the brain. Nature. 459: 1005-9. PMID 19421193 DOI: 10.1038/Nature08021  1
2009 Serganova I, Moroz E, Vider J, Gogiberidze G, Moroz M, Pillarsetty N, Doubrovin M, Minn A, Thaler HT, Massague J, Gelovani J, Blasberg R. Multimodality imaging of TGFbeta signaling in breast cancer metastases. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 2662-72. PMID 19325038 DOI: 10.1096/Fj.08-126920  0.4
2009 Nguyen DX, Bos PD, Massagué J. Metastasis: from dissemination to organ-specific colonization. Nature Reviews. Cancer. 9: 274-84. PMID 19308067 DOI: 10.1038/Nrc2622  1
2008 Padua D, Zhang XH, Wang Q, Nadal C, Gerald WL, Gomis RR, Massagué J. TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell. 133: 66-77. PMID 18394990 DOI: 10.1016/J.Cell.2008.01.046  0.4
2008 Tavazoie SF, Alarcón C, Oskarsson T, Padua D, Wang Q, Bos PD, Gerald WL, Massagué J. Endogenous human microRNAs that suppress breast cancer metastasis. Nature. 451: 147-52. PMID 18185580 DOI: 10.1038/Nature06487  1
2008 Xi Q, He W, Zhang XH, Le HV, Massagué J. Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor beta transcriptional program. The Journal of Biological Chemistry. 283: 1146-55. PMID 18003620 DOI: 10.1074/Jbc.M707479200  1
2007 Gupta GP, Perk J, Acharyya S, de Candia P, Mittal V, Todorova-Manova K, Gerald WL, Brogi E, Benezra R, Massagué J. ID genes mediate tumor reinitiation during breast cancer lung metastasis. Proceedings of the National Academy of Sciences of the United States of America. 104: 19506-11. PMID 18048329 DOI: 10.1073/Pnas.0709185104  1
2007 Rodina A, Vilenchik M, Moulick K, Aguirre J, Kim J, Chiang A, Litz J, Clement CC, Kang Y, She Y, Wu N, Felts S, Wipf P, Massague J, Jiang X, et al. Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. Nature Chemical Biology. 3: 498-507. PMID 17603540 DOI: 10.1038/Nchembio.2007.10  1
2007 Nguyen DX, Massagué J. Genetic determinants of cancer metastasis. Nature Reviews. Genetics. 8: 341-52. PMID 17440531 DOI: 10.1038/Nrg2101  1
2007 Gupta GP, Nguyen DX, Chiang AC, Bos PD, Kim JY, Nadal C, Gomis RR, Manova-Todorova K, Massagué J. Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature. 446: 765-70. PMID 17429393 DOI: 10.1038/Nature05760  1
2007 Minn AJ, Gupta GP, Padua D, Bos P, Nguyen DX, Nuyten D, Kreike B, Zhang Y, Wang Y, Ishwaran H, Foekens JA, van de Vijver M, Massagué J. Lung metastasis genes couple breast tumor size and metastatic spread. Proceedings of the National Academy of Sciences of the United States of America. 104: 6740-5. PMID 17420468 DOI: 10.1073/Pnas.0701138104  1
2007 Sapkota G, Alarcón C, Spagnoli FM, Brivanlou AH, Massagué J. Balancing BMP signaling through integrated inputs into the Smad1 linker. Molecular Cell. 25: 441-54. PMID 17289590 DOI: 10.1016/J.Molcel.2007.01.006  1
2007 Li F, Tiede B, Massagué J, Kang Y. Beyond tumorigenesis: cancer stem cells in metastasis. Cell Research. 17: 3-14. PMID 17179981 DOI: 10.1038/Sj.Cr.7310118  0.96
2006 Gupta GP, Massagué J. Cancer metastasis: building a framework. Cell. 127: 679-95. PMID 17110329 DOI: 10.1016/J.Cell.2006.11.001  0.96
2006 Sapkota G, Knockaert M, Alarcón C, Montalvo E, Brivanlou AH, Massagué J. Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways. The Journal of Biological Chemistry. 281: 40412-9. PMID 17085434 DOI: 10.1074/Jbc.M610172200  1
2006 Gomis RR, Alarcón C, He W, Wang Q, Seoane J, Lash A, Massagué J. A FoxO-Smad synexpression group in human keratinocytes. Proceedings of the National Academy of Sciences of the United States of America. 103: 12747-52. PMID 16908841 DOI: 10.1073/Pnas.0605333103  1
2006 Knockaert M, Sapkota G, Alarcón C, Massagué J, Brivanlou AH. Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling. Proceedings of the National Academy of Sciences of the United States of America. 103: 11940-5. PMID 16882717 DOI: 10.1073/Pnas.0605133103  1
2006 He W, Dorn DC, Erdjument-Bromage H, Tempst P, Moore MA, Massagué J. Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. Cell. 125: 929-41. PMID 16751102 DOI: 10.1016/J.Cell.2006.03.045  0.4
2006 Kang Y, He W, Tulley S, Gupta GP, Serganova I, Chen CR, Manova-Todorova K, Blasberg R, Gerald WL, Massagué J. Erratum: Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway (Proceedings of the National Academy of Sciences of the United States of America) (September 27, 2005) 102 (13909-13914) DOI: 10.1073/pnas.0506517102)) Proceedings of the National Academy of Sciences of the United States of America. 103. DOI: 10.1073/Pnas.0603221103  0.96
2005 Massagué J, Seoane J, Wotton D. Smad transcription factors. Genes & Development. 19: 2783-810. PMID 16322555 DOI: 10.1101/Gad.1350705  1
2005 Thomas DA, Massagué J. TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. Cancer Cell. 8: 369-80. PMID 16286245 DOI: 10.1016/J.Ccr.2005.10.012  1
2005 Kang Y, He W, Tulley S, Gupta GP, Serganova I, Chen CR, Manova-Todorova K, Blasberg R, Gerald WL, Massagué J. Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proceedings of the National Academy of Sciences of the United States of America. 102: 13909-14. PMID 16172383 DOI: 10.1073/Pnas.0506517102  1
2005 Le HV, Minn AJ, Massagué J. Cyclin-dependent kinase inhibitors uncouple cell cycle progression from mitochondrial apoptotic functions in DNA-damaged cancer cells. The Journal of Biological Chemistry. 280: 32018-25. PMID 16002406 DOI: 10.1074/Jbc.M504689200  1
2005 Minn AJ, Kang Y, Serganova I, Gupta GP, Giri DD, Doubrovin M, Ponomarev V, Gerald WL, Blasberg R, Massagué J. Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. The Journal of Clinical Investigation. 115: 44-55. PMID 15630443 DOI: 10.1172/Jci22320  0.96
2004 Gupta GP, Massagué J. Platelets and metastasis revisited: a novel fatty link. The Journal of Clinical Investigation. 114: 1691-3. PMID 15599391 DOI: 10.1172/JCI23823  0.96
2004 Kang Y, Massagué J. Epithelial-mesenchymal transitions: twist in development and metastasis. Cell. 118: 277-9. PMID 15294153 DOI: 10.1016/J.Cell.2004.07.011  0.96
2004 Seoane J, Le HV, Shen L, Anderson SA, Massagué J. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell. 117: 211-23. PMID 15084259 DOI: 10.1016/S0092-8674(04)00298-3  1
2004 Xu L, Massagué J. Nucleocytoplasmic shuttling of signal transducers. Nature Reviews. Molecular Cell Biology. 5: 209-19. PMID 14991001 DOI: 10.1038/Nrm1331  0.48
2004 Massagué J, Attisano L, Wrana JL. The TGF-beta family and its composite receptors. Trends in Cell Biology. 4: 172-8. PMID 14731645 DOI: 10.1016/0962-8924(94)90202-X  0.32
2004 Gupta GP, Massagué J. Platelets and metastasis revisited: a novel fatty link Journal of Clinical Investigation. 114: 1691-1693. DOI: 10.1172/Jci200423823  0.96
2003 Foletta VC, Lim MA, Soosairajah J, Kelly AP, Stanley EG, Shannon M, He W, Das S, Massague J, Bernard O, Soosairaiah J. Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1. The Journal of Cell Biology. 162: 1089-98. PMID 12963706 DOI: 10.1083/Jcb.200212060  1
2003 Xu L, Alarcón C, Cöl S, Massagué J. Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import. The Journal of Biological Chemistry. 278: 42569-77. PMID 12917407 DOI: 10.1074/Jbc.M307601200  0.48
2003 Kang Y, Chen CR, Massagué J. A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Molecular Cell. 11: 915-26. PMID 12718878 DOI: 10.1016/S1097-2765(03)00109-6  1
2003 Chai J, Wu JW, Yan N, Massagué J, Pavletich NP, Shi Y. Features of a Smad3 MH1-DNA complex: Roles of water and zinc in DNA binding Journal of Biological Chemistry. 278: 20327-20331. PMID 12686552 DOI: 10.1074/Jbc.C300134200  1
2002 Seoane J, Le HV, Massagué J. Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature. 419: 729-34. PMID 12384701 DOI: 10.1038/Nature01119  1
2002 Xu L, Kang Y, Cöl S, Massagué J. Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus. Molecular Cell. 10: 271-82. PMID 12191473 DOI: 10.1016/S1097-2765(02)00586-5  0.96
2002 López-Rovira T, Chalaux E, Massagué J, Rosa JL, Ventura F. Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 gene. The Journal of Biological Chemistry. 277: 3176-85. PMID 11700304 DOI: 10.1074/Jbc.M106826200  0.36
2001 Wu JW, Hu M, Chai J, Seoane J, Huse M, Li C, Rigotti DJ, Kyin S, Muir TW, Fairman R, Massagué J, Shi Y. Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling. Molecular Cell. 8: 1277-89. PMID 11779503 DOI: 10.1016/S1097-2765(01)00421-X  1
2001 Huse M, Muir TW, Xu L, Chen YG, Kuriyan J, Massagué J. The TGF beta receptor activation process: an inhibitor- to substrate-binding switch. Molecular Cell. 8: 671-82. PMID 11583628 DOI: 10.1016/S1097-2765(01)00332-X  1
2001 Lo RS, Wotton D, Massagué J. Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF Embo Journal. 20: 128-136. PMID 11226163 DOI: 10.1093/Emboj/20.1.128  1
2001 Chen CR, Kang Y, Massagué J. Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor β growth arrest program Proceedings of the National Academy of Sciences of the United States of America. 98: 992-999. PMID 11158583 DOI: 10.1073/Pnas.98.3.992  1
2000 Wotton D, Massague J. Smad transcriptional corepressors in TGFβ family signaling Current Topics in Microbiology and Immunology. 254: 145-164. PMID 11190572  1
2000 Massagué J, Blain SW, Lo RS. TGFβ signaling in growth control, cancer, and heritable disorders Cell. 103: 295-309. PMID 11057902 DOI: 10.1016/S0092-8674(00)00121-5  1
2000 Xu L, Chen Y, Massagué J. The nuclear import function of Smad2 is masked by SARA and unmasked by TGFb-dependent phosphorylation Nature Cell Biology. 2: 559-562. PMID 10934479 DOI: 10.1038/35019649  0.48
2000 Gripp KW, Wotton D, Edwards MC, Roessler E, Ades L, Meinecke P, Richieri-Costa A, Zackai EH, Massagué J, Muenke M, Elledge SJ. Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination Nature Genetics. 25: 205-208. PMID 10835638 DOI: 10.1038/76074  1
2000 Massagué J, Wotton D. Transcriptional control by the TGF-β/Smad signaling system Embo Journal. 19: 1745-1754. PMID 10775259 DOI: 10.1093/Emboj/19.8.1745  1
2000 Hata A, Seoane J, Lagna G, Montalvo E, Hemmati-Brivanlou A, Massagué J. OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. Cell. 100: 229-40. PMID 10660046 DOI: 10.1016/S0092-8674(00)81561-5  1
1999 Wotton D, Lo RS, Swaby LAC, Massagué J. Multiple modes of repression by the Smad transcriptional corepressor TGIF Journal of Biological Chemistry. 274: 37105-37110. PMID 10601270 DOI: 10.1074/Jbc.274.52.37105  1
1999 Lo RS, Massagué J. Ubiquitin-dependent degradation of TGF-β-activated Smad2 Nature Cell Biology. 1: 472-478. PMID 10587642 DOI: 10.1038/70258  1
1999 Wotton D, Lo RS, Lee S, Massagué J. A Smad transcriptional corepressor Cell. 97: 29-39. PMID 10199400 DOI: 10.1016/S0092-8674(00)80712-6  1
1999 Huse M, Chen YG, Massagué J, Kuriyan J. Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12. Cell. 96: 425-36. PMID 10025408 DOI: 10.1016/S0092-8674(00)80555-3  1
1999 Yin JJ, Selander K, Chirgwin JM, Dallas M, Grubbs BG, Wieser R, Massagué J, Mundy GR, Guise TA. TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. The Journal of Clinical Investigation. 103: 197-206. PMID 9916131 DOI: 10.1172/Jci3523  0.36
1998 Liu F, Massagué J, Ruiz i Altaba A. Carboxy-terminally truncated Gli3 proteins associate with Smads. Nature Genetics. 20: 325-6. PMID 9843199 DOI: 10.1038/3793  1
1998 Shi Y, Wang YF, Jayaraman L, Yang H, Massagué J, Pavletich NP. Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-β signaling Cell. 94: 585-594. PMID 9741623 DOI: 10.1016/S0092-8674(00)81600-1  1
1998 Mahony D, Weis FM, Massagué J, Gurdon JB. XTrR-I is a TGFbeta receptor and overexpression of truncated form of the receptor inhibits axis formation and dorsalising activity. Mechanisms of Development. 75: 95-105. PMID 9739114 DOI: 10.1016/S0925-4773(98)00092-6  1
1998 Cordon-Cardo C, Koff A, Drobnjak M, Capodieci P, Osman I, Millard SS, Gaudin PB, Fazzari M, Zhang ZF, Massague J, Scher HI. Distinct altered patterns of p27KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinoma. Journal of the National Cancer Institute. 90: 1284-91. PMID 9731735 DOI: 10.1093/Jnci/90.17.1284  1
1998 Chen YG, Hata A, Lo RS, Wotton D, Shi Y, Pavletich N, Massagué J. Determinants of specificity in TGF-β signal transduction Genes and Development. 12: 2144-2152. PMID 9679059 DOI: 10.1101/Gad.12.14.2144  1
1998 Lo RS, Chen YG, Shi Y, Pavletich NP, Massagué J. The L3 loop: A structural motif determining specific interactions between SMAD proteins and TGF-β receptors Embo Journal. 17: 996-1005. PMID 9463378 DOI: 10.1093/Emboj/17.4.996  1
1997 Zou H, Choe KM, Lu Y, Massagué J, Niswander L. BMP signaling and vertebrate limb development. Cold Spring Harbor Symposia On Quantitative Biology. 62: 269-72. PMID 9598360 DOI: 10.1101/Sqb.1997.062.01.033  1
1997 Blain SW, Montalvo E, Massagué J. Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4. The Journal of Biological Chemistry. 272: 25863-72. PMID 9325318 DOI: 10.1074/Jbc.272.41.25863  1
1997 Zou H, Wieser R, Massagué J, Niswander L. Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage. Genes & Development. 11: 2191-203. PMID 9303535 DOI: 10.1101/Gad.11.17.2191  1
1997 Shi Y, Hata A, Lo RS, Massagué J, Pavletich NP. A structural basis for mutational inactivation of the tumour suppressor Smad4 Nature. 388: 87-93. PMID 9214508 DOI: 10.1038/40431  1
1997 Hata A, Lo RS, Wotton D, Lagna G, Massagué J. Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4 Nature. 388: 82-87. PMID 9214507 DOI: 10.1038/40424  1
1997 Yan Y, Frisén J, Lee MH, Massagué J, Barbacid M. Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development. Genes & Development. 11: 973-83. PMID 9136926 DOI: 10.1101/Gad.11.8.973  1
1996 Derynck R, Gelbart WM, Harland RM, Heldin CH, Kern SE, Massagué J, Melton DA, Mlodzik M, Padgett RW, Roberts AB, Smith J, Thomsen GH, Vogelstein B, Wang XF. Nomenclature: vertebrate mediators of TGFbeta family signals. Cell. 87: 173. PMID 8861901 DOI: 10.1016/S0092-8674(00)81335-5  1
1996 Russo AA, Jeffrey PD, Patten AK, Massagué J, Pavletich NP. Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature. 382: 325-31. PMID 8684460 DOI: 10.1038/382325A0  1
1996 Ventura F, Liu F, Doody J, Massagué J. Interaction of Transforming Growth Factor-β Receptor I with Farnesyl-protein Transferase-α in Yeast and Mammalian Cells Journal of Biological Chemistry. 271: 13931-13934. PMID 8663177 DOI: 10.1074/Jbc.271.24.13931  0.36
1996 Liu F, Hata A, Baker JC, Doody J, Cárcamo J, Harland RM, Massagué J. A human Mad protein acting as a BMP-regulated transcriptional activator. Nature. 381: 620-3. PMID 8637600 DOI: 10.1038/381620A0  1
1996 Lee MH, Nikolic M, Baptista CA, Lai E, Tsai LH, Massagué J. The brain-specific activator p35 allows Cdk5 to escape inhibition by p27Kip1 in neurons. Proceedings of the National Academy of Sciences of the United States of America. 93: 3259-63. PMID 8622924 DOI: 10.1073/Pnas.93.8.3259  1
1996 Attisano L, Wrana JL, Montalvo E, Massagué J. Activation of signalling by the activin receptor complex. Molecular and Cellular Biology. 16: 1066-73. PMID 8622651 DOI: 10.1128/Mcb.16.3.1066  1
1995 Cárcamo J, Zentella A, Massagué J. Disruption of transforming growth factor beta signaling by a mutation that prevents transphosphorylation within the receptor complex. Molecular and Cellular Biology. 15: 1573-1581. PMID 7862150 DOI: 10.1128/Mcb.15.3.1573  0.36
1995 Liu F, Ventura F, Doody J, Massague J. Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. Molecular and Cellular Biology. 15: 3479-3486. PMID 7791754 DOI: 10.1128/Mcb.15.7.3479  0.36
1995 Vivien D, Attisano L, Wrana JL, Massagué J. Signaling activity of homologous and heterologous transforming growth factor-beta receptor kinase complexes. The Journal of Biological Chemistry. 270: 7134-41. PMID 7706250 DOI: 10.1074/Jbc.270.13.7134  0.44
1995 Letsou A, Arora K, Wrana JL, Simin K, Twombly V, Jamal J, Staehling-Hampton K, Hoffmann FM, Gelbart WM, Massagué J. Drosophila Dpp signaling is mediated by the punt gene product: a dual ligand-binding type II receptor of the TGF beta receptor family. Cell. 80: 899-908. PMID 7697720 DOI: 10.1016/0092-8674(95)90293-7  1
1995 Jeffrey PD, Russo AA, Polyak K, Gibbs E, Hurwitz J, Massagué J, Pavletich NP. Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature. 376: 313-20. PMID 7630397 DOI: 10.1038/376313A0  1
1994 Wrana JL, Tran H, Attisano L, Arora K, Childs SR, Massagué J, O'Connor MB. Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex Molecular and Cellular Biology. 14: 944-950. PMID 8289834 DOI: 10.1128/Mcb.14.2.944  1
1994 Polyak K, Kato JY, Solomon MJ, Sherr CJ, Massague J, Roberts JM, Koff A. P27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest Genes and Development. 8: 9-22. PMID 8288131 DOI: 10.1101/Gad.8.1.9  1
1994 Cárcamo J, Weis FM, Ventura F, Wieser R, Wrana JL, Attisano L, Massagué J. Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin. Molecular and Cellular Biology. 14: 3810-21. PMID 8196624 DOI: 10.1128/Mcb.14.6.3810  0.4
1994 Attisano L, Wrana JL, López-Casillas F, Massagué J. TGF-beta receptors and actions. Biochimica Et Biophysica Acta. 1222: 71-80. PMID 8186268 DOI: 10.1016/0167-4889(94)90026-4  0.4
1994 Koenig BB, Cook JS, Wolsing DH, Ting J, Tiesman JP, Correa PE, Olson CA, Pecquet AL, Ventura F, Grant RA. Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells. Molecular and Cellular Biology. 14: 5961-74. PMID 8065329 DOI: 10.1128/Mcb.14.9.5961  1
1994 Wrana JL, Attisano L, Wieser R, Ventura F, Massagué J. Mechanism of activation of the TGF-beta receptor. Nature. 370: 341-7. PMID 8047140 DOI: 10.1038/370341A0  0.4
1994 Brummel TJ, Twombly V, Marqués G, Wrana JL, Newfeld SJ, Attisano L, Massagué J, O'Connor MB, Gelbart WM. Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila. Cell. 78: 251-61. PMID 8044839 DOI: 10.1016/0092-8674(94)90295-X  1
1994 Penton A, Chen Y, Staehling-Hampton K, Wrana JL, Attisano L, Szidonya J, Cassill JA, Massagué J, Hoffmann FM. Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor. Cell. 78: 239-50. PMID 8044838 DOI: 10.1016/0092-8674(94)90294-1  1
1994 Kato JY, Matsuoka M, Polyak K, Massagué J, Sherr CJ. Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation Cell. 79: 487-496. PMID 7954814 DOI: 10.1016/0092-8674(94)90257-7  1
1993 Koff A, Ohtsuki M, Polyak K, Roberts JM, Massagué J. Negative regulation of G1 in mammalian cells: Inhibition of cyclin E-dependent kinase by TGF-β Science. 260. PMID 8475385 DOI: 10.1126/Science.8475385  1
1993 Childs SR, Wrana JL, Arora K, Attisano L, O'Connor MB, Massagué J. Identification of a Drosophila activin receptor Proceedings of the National Academy of Sciences of the United States of America. 90: 9475-9479. PMID 8415726 DOI: 10.1073/Pnas.90.20.9475  1
1993 Estevez M, Attisano L, Wrana JL, Albert PS, Massagué J, Riddle DL. The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development. Nature. 365: 644-9. PMID 8413626 DOI: 10.1038/365644A0  1
1993 López-Casillas F, Wrana JL, Massagué J. Betaglycan presents ligand to the TGF beta signaling receptor. Cell. 73: 1435-44. PMID 8391934 DOI: 10.1016/0092-8674(93)90368-Z  0.52
1993 Wieser R, Attisano L, Wrana JL, Massagué J. Signaling activity of transforming growth factor beta type II receptors lacking specific domains in the cytoplasmic region. Molecular and Cellular Biology. 13: 7239-47. PMID 8246946 DOI: 10.1128/Mcb.13.12.7239  0.4
1993 López-Casillas F, Wrana J, Massagué J. Receptor of the third kind Trends in Cell Biology. 3: 334. DOI: 10.1016/0962-8924(93)90100-F  0.36
1992 Lidholt K, Weinke JL, Kiser CS, Lugemwa FN, Bame KJ, Cheifetz S, Massagué J, Lindahl U, Esko JD. A single mutation affects both N-acetylglucosaminyltransferase and glucuronosyltransferase activities in a Chinese hamster ovary cell mutant defective in heparan sulfate biosynthesis Proceedings of the National Academy of Sciences of the United States of America. 89: 2267-2271. PMID 1532254 DOI: 10.1073/Pnas.89.6.2267  1
1992 Attisano L, Wrana JL, Cheifetz S, Massagué J. Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors. Cell. 68: 97-108. PMID 1310075 DOI: 10.1016/0092-8674(92)90209-U  0.44
1991 Leonard CM, Fuld HM, Frenz DA, Downie SA, Massagué J, Newman SA. Role of transforming growth factor-beta in chondrogenic pattern formation in the embryonic limb: stimulation of mesenchymal condensation and fibronectin gene expression by exogenenous TGF-beta and evidence for endogenous TGF-beta-like activity. Developmental Biology. 145: 99-109. PMID 2019328 DOI: 10.1016/0012-1606(91)90216-P  1
1991 Laiho M, Rönnstrand L, Heino J, Decaprio JA, Ludlow JW, Livingston DM, Massagué J. Control of JunB and Extracellular Matrix Protein Expression by Transforming Growth Factor-β1 Is Independent of Simian Virus 40 T Antigen-Sensitive Growth-Inhibitory Events Molecular and Cellular Biology. 11: 972-978. PMID 1990295 DOI: 10.1128/Mcb.11.2.972  1
1990 Laiho M, DeCaprio JA, Ludlow JW, Livingston DM, Massague J. Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation Cell. 62: 175-185. PMID 2163767 DOI: 10.1016/0092-8674(90)90251-9  1
1988 Luetteke NC, Michalopoulos GK, Teixidó J, Gilmore R, Massagué J, Lee DC. Characterization of high molecular weight transforming growth factor α produced by rat hepatocellular carcinoma cells Biochemistry. 27: 6487-6494. PMID 3219349 DOI: 10.1021/Bi00417A043  1
1988 Kimchi A, Wang XF, Weinberg RA, Cheifetz S, Massagué J. Absence of TGF-β receptors and growth inhibitory responses in retinoblastoma cells Science. 240: 196-199. PMID 2895499 DOI: 10.1126/Science.2895499  1
1987 Cheifetz S, Weatherbee JA, Tsang MLS, Anderson JK, Mole JE, Lucas R, Massagué J. The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors Cell. 48: 409-415. PMID 2879635 DOI: 10.1016/0092-8674(87)90192-9  1
1985 Massagué J, Czech MP. [14] Affinity cross-linking of receptors for insulin and the insulin-like growth factors I and II Methods in Enzymology. 109: 179-187. DOI: 10.1016/0076-6879(85)09084-X  1
1984 Borland K, Mita M, Oppenheimer CL, Blinderman LA, Massague J, Hall PF, Czech MP. The actions of insulin-like growth factors I and II on cultured Sertoli cells. Endocrinology. 114: 240-6. PMID 6360662 DOI: 10.1210/Endo-114-1-240  1
1984 Czech MP, Massagué J, Seals JR, Yu K. CHAPTER 4 – Mechanisms of Biological Signaling by the Insulin Receptor Biochemical Actions of Hormones. 93-125. DOI: 10.1016/B978-0-12-452811-6.50009-8  1
1983 Massague J, Freidenberg GF, Olefsky JM, Czech MP. Parallel decreases in the expression of receptors for insulin and insulin-like growth factor I in a mutant human fibroblast line Diabetes. 32: 541-544. PMID 6313454 DOI: 10.2337/Diab.32.6.541  1
1983 Massague J, Buxser S, Johnson GL, Czech MP. Affinity labeling of a nerve growth factor receptor component on rat pheochromocytoma (PC12) cells. Biochimica Et Biophysica Acta. 693: 205-12. PMID 6295482 DOI: 10.1016/0005-2736(82)90488-6  0.48
1983 Oppenheimer CL, Pessin JE, Massague J, Gitomer W, Czech MP. Insulin action rapidly modulates the apparent affinity of the insulin-like growth factor II receptor. Journal of Biological Chemistry. 258: 4824-4830. DOI: 10.1016/s0021-9258(18)32499-2  0.32
1982 Massague J, Czech MP, Iwata K, DeLarco JE, Todaro GJ. Affinity labeling of a transforming growth factor receptor that does not interact with epidermal growth factor. Proceedings of the National Academy of Sciences of the United States of America. 79: 6822-6. PMID 6294655 DOI: 10.1073/Pnas.79.22.6822  1
1982 Massagué J, Blinderman LA, Czech MP. The high affinity insulin receptor mediates growth stimulation in rat hepatoma cells. Journal of Biological Chemistry. 257: 13958-13963. DOI: 10.1016/s0021-9258(19)45326-x  0.4
1982 Massagué J, Czech MP. The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor. Journal of Biological Chemistry. 257: 5038-5045. DOI: 10.1016/s0021-9258(18)34631-3  0.4
1982 Massagué J, Czech MP. Role of disulfides in the subunit structure of the insulin receptor. Reduction of class I disulfides does not impair transmembrane signalling. Journal of Biological Chemistry. 257: 6729-6738. DOI: 10.1016/s0021-9258(18)34491-0  0.4
1981 Czech MP, Massague J, Pilch PF. The insulin receptor: structural features Trends in Biochemical Sciences. 6: 222-225. DOI: 10.1016/0968-0004(81)90081-5  1
1980 Massaqué J, Czech MP. Multiple redox forms of the insulin receptor in native liver membranes. Diabetes. 29: 945-7. PMID 7429030 DOI: 10.2337/Diab.29.11.945  0.6
1980 Czech MP, Massague J, Pilch PF, Carter-Su C. Structural features of the insulin effector system: Relation to hexose transport activation Annals of the New York Academy of Sciences. 282-291. PMID 7011146 DOI: 10.1111/J.1749-6632.1980.Tb15401.X  1
1980 Massague J, Pilch PF, Czech MP. Electrophoretic resolution of three major insulin receptor structures with unique subunit stoichiometries Proceedings of the National Academy of Sciences of the United States of America. 77: 7137-7141. PMID 6938960 DOI: 10.1073/Pnas.77.12.7137  1
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