Avrum Spira - Publications

Affiliations: 
Boston University, Boston, MA, United States 
Area:
Bioinformatics Biology, Molecular Biology, Biostatistics Biology

239 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Maoz A, Merenstein C, Koga Y, Potter A, Gower AC, Liu G, Zhang S, Liu H, Stevenson C, Spira A, Reid ME, Campbell JD, Mazzilli SA, Lenburg ME, Beane J. Elevated T cell repertoire diversity is associated with progression of lung squamous cell premalignant lesions. Journal For Immunotherapy of Cancer. 9. PMID 34580161 DOI: 10.1136/jitc-2021-002647  1
2021 Kammer MN, Lakhani DA, Balar AB, Antic SL, Kussrow AK, Webster RL, Mahapatra S, Barad U, Shah C, Atwater T, Diergaarde B, Qian J, Kaizer A, New M, Hirsch E, ... ... Spira A, et al. Integrated Biomarkers for the Management of Indeterminate Pulmonary Nodules. American Journal of Respiratory and Critical Care Medicine. PMID 34464235 DOI: 10.1164/rccm.202012-4438OC  1
2021 Becker EJ, Faiz A, van den Berge M, Timens W, Hiemstra PS, Clark K, Liu G, Xiao X, Alekseyev YO, O'Connor G, Lam S, Spira A, Lenburg ME, Steiling K. Bronchial gene expression signature associated with rate of subsequent FEV decline in individuals with and at risk of COPD. Thorax. PMID 33972452 DOI: 10.1136/thoraxjnl-2019-214476  1
2021 Sinjab A, Han G, Treekitkarnmongkol W, Hara K, Brennan PM, Dang M, Hao D, Wang R, Dai E, Dejima H, Zhang J, Bogatenkova E, Sanchez-Espiridion B, Chang K, Little DR, ... ... Spira A, et al. Resolving the spatial and cellular architecture of lung adenocarcinoma by multiregion single-cell sequencing. Cancer Discovery. PMID 33972311 DOI: 10.1158/2159-8290.CD-20-1285  1
2021 Tilston-Lunel A, Mazzilli S, Kingston NM, Szymaniak AD, Hicks-Berthet J, Kern JG, Abo K, Reid ME, Perdomo C, Wilson AA, Spira A, Beane J, Varelas X. Aberrant epithelial polarity cues drive the development of precancerous airway lesions. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33903236 DOI: 10.1073/pnas.2019282118  1
2021 Xu F, Tanabe N, Vasilescu DM, McDonough JE, Coxson HC, Ikezoe K, Kinose D, Ng KW, Verleden SE, Wuyts WA, Vanaudenaerde BM, Verschakelen J, Cooper JD, Lenburg ME, Morshead KB, ... ... Spira A, et al. The transition from normal lung anatomy to minimal and established fibrosis in idiopathic pulmonary fibrosis (IPF). Ebiomedicine. 66: 103325. PMID 33862585 DOI: 10.1016/j.ebiom.2021.103325  1
2021 Han G, Sinjab A, Hara K, Treekitkarnmongkol W, Brennan P, Chang K, Bogatenkova E, Sanchez-Espiridion B, Behrens C, Solis LM, Gao B, Girard L, Zhang J, Sepesi B, Cascone T, ... ... Spira AE, et al. Single-Cell Expression Landscape of SARS-CoV-2 Receptor and Host Proteases in Normal and Malignant Lung Tissues from Pulmonary Adenocarcinoma Patients. Cancers. 13. PMID 33809063 DOI: 10.3390/cancers13061250  1
2021 Fan X, Johnson BH, Johnston SS, Elangovanraaj N, Kothari P, Spira A, Coplan P, Khanna R. Monthly Trend in Mortality and Length of Stay among COVID-19 Patients: Analysis of a Nationwide Multi-Hospital United States Database. Infection Control and Hospital Epidemiology. 1-8. PMID 33736712 DOI: 10.1017/ice.2021.110  0.24
2020 Ostrin EJ, Sidransky D, Spira A, Hanash SM. Biomarkers for lung cancer screening and detection. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. PMID 33093160 DOI: 10.1158/1055-9965.EPI-20-0865  0.28
2020 Faiz A, Imkamp K, van der Wiel E, Boudewijn IM, Koppelman GH, Brandsma CA, Kerstjens HAM, Timens W, Vroegop S, Pasma HR, Boersma WG, Wielders P, van den Elshout F, Mansour K, Steiling K, ... Spira A, et al. Identifying a nasal gene expression signature associated with hyperinflation and treatment response in severe COPD. Scientific Reports. 10: 17415. PMID 33060632 DOI: 10.1038/s41598-020-72551-0  1
2020 Billatos E, Ash SY, Duan F, Xu K, Romanoff J, Marques H, Moses E, Han MK, Regan EA, Bowler RP, Mason SE, Doyle TJ, San José Estépar R, Rosas IO, Ross JC, ... ... Spira A, et al. Distinguishing smoking related lung disease phenotypes via imaging and molecular features. Chest. PMID 32946850 DOI: 10.1016/J.Chest.2020.08.2115  1
2020 Lee HJ, Mazzone P, Feller-Kopman D, Yarmus L, Hogarth K, Lofaro LR, Griscom B, Johnson M, Choi Y, Huang J, Bhorade S, Spira A, Kennedy GC, Wahidi MM. Impact of the Percepta Genomic Classifier on Clinical Management Decisions in a Multicenter Prospective Study. Chest. PMID 32758562 DOI: 10.1016/J.Chest.2020.07.067  1
2020 Treekitkarnmongkol W, Hassane M, Sinjab A, Chang K, Hara K, Rahal Z, Zhang J, Lu W, Sivakumar S, McDowell TL, Kantrowitz J, Zhou J, Lang W, Xu L, Ochieng JK, ... ... Spira AE, et al. Augmented Lipocalin-2 is Associated with COPD and Counteracts Lung Adenocarcinoma Development. American Journal of Respiratory and Critical Care Medicine. PMID 32730093 DOI: 10.1164/Rccm.202004-1079Oc  1
2020 Sofer T, Li R, Joehanes R, Lin H, Gower AC, Wang H, Kurniansyah N, Cade BE, Lee J, Williams S, Mehra R, Patel SR, Quan SF, Liu Y, Rotter JI, ... ... Spira A, et al. Low oxygen saturation during sleep reduces CD1D and RAB20 expressions that are reversed by CPAP therapy. Ebiomedicine. 56: 102803. PMID 32512511 DOI: 10.1016/J.Ebiom.2020.102803  1
2020 Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, Feldman J, Muus C, Wadsworth MH, Kazer SW, Hughes TK, et al. SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. Cell. PMID 32413319 DOI: 10.1016/J.Cell.2020.04.035  0.12
2020 Rozenblatt-Rosen O, Regev A, Oberdoerffer P, Nawy T, Hupalowska A, Rood JE, Ashenberg O, Cerami E, Coffey RJ, Demir E, Ding L, Esplin ED, Ford JM, Goecks J, Ghosh S, ... ... Spira AE, et al. The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution. Cell. 181: 236-249. PMID 32302568 DOI: 10.1016/J.Cell.2020.03.053  1
2020 Drizik E, Corbett S, Zheng Y, Vermeulen R, Dai Y, Hu W, Ren D, Duan H, Niu Y, Xu J, Fu W, Meliefste K, Zhou B, Zhang X, Yang J, ... ... Spira A, et al. Transcriptomic changes in the nasal epithelium associated with diesel engine exhaust exposure. Environment International. 137: 105506. PMID 32044442 DOI: 10.1016/J.Envint.2020.105506  1
2020 Shi X, Zhang J, Callori S, Campbell J, Fine D, Gesthalter Y, Liu G, Xiao X, Spira A, Lenburg M, Beane J. Abstract 3377: NSCLC subtype-associated molecular and cellular alterations in the normal-appearing bronchial epithelium Cancer Research. 80: 3377-3377. DOI: 10.1158/1538-7445.Am2020-3377  1
2020 Merenstein C, Breda J, Mazzilli S, Burks E, Stevenson C, Reid M, Spira A, Lenburg M, Beane J. Abstract 1098: Mediators of early immune response in bronchial premalignant lesions Tumor Biology. DOI: 10.1158/1538-7445.Am2020-1098  1
2019 Duclos GE, Teixeira VH, Autissier P, Gesthalter YB, Reinders-Luinge MA, Terrano R, Dumas YM, Liu G, Mazzilli SA, Brandsma CA, van den Berge M, Janes SM, Timens W, Lenburg ME, Spira A, et al. Characterizing smoking-induced transcriptional heterogeneity in the human bronchial epithelium at single-cell resolution. Science Advances. 5: eaaw3413. PMID 31844660 DOI: 10.1126/Sciadv.Aaw3413  1
2019 Zhang T, Chillrud SN, Yang Q, Pitiranggon M, Ross J, Perera F, Ji J, Spira A, Breysse PN, Rodes C, Miller R, Yan B. Characterizing peak exposure of secondhand smoke using a real-time PM monitor. Indoor Air. PMID 31610044 DOI: 10.1111/Ina.12611  0.28
2019 Garland L, Guillen-Rodriguez J, Hsu CH, Yozwiak M, Zhang HH, Alberts DS, Davis LE, Szabo E, Merenstein C, Lel J, Zhang X, Liu H, Liu G, Spira AE, Beane J, et al. Effect of intermittent versus continuous low dose aspirin on nasal epithelium gene expression in current smokers: A randomized, double-blinded trial. Cancer Prevention Research (Philadelphia, Pa.). PMID 31451521 DOI: 10.1158/1940-6207.Capr-19-0036  1
2019 Corbett SE, Nitzberg M, Moses E, Kleerup E, Wang T, Perdomo C, Perdomo C, Liu G, Zhang S, Liu H, Elashoff DA, Brooks DR, O'Connor GT, Dubinett SM, Spira A, et al. Gene Expression Alterations in the Bronchial Epithelium of Electronic Cigarette Users. Chest. PMID 31233743 DOI: 10.1016/J.Chest.2019.05.022  1
2019 Krysan K, Tran LM, Grimes BS, Fishbein GA, Seki A, Gardner BK, Walser TC, Salehi-Rad R, Yanagawa J, Lee JM, Sharma S, Aberle D, Spira AE, Elashoff DA, Wallace WD, et al. The immune contexture associates with the genomic landscape in lung adenomatous premalignancy. Cancer Research. PMID 31142513 DOI: 10.1158/0008-5472.Can-19-0153  1
2019 Hijazi K, Malyszko B, Steiling K, Xiao X, Liu G, Alekseyev YO, Dumas YM, Hertsgaard L, Jensen J, Hatsukami D, Brooks DR, O'Connor G, Beane J, Lenburg ME, Spira A. Tobacco-Related Alterations in Airway Gene Expression are Rapidly Reversed Within Weeks Following Smoking-Cessation. Scientific Reports. 9: 6978. PMID 31061400 DOI: 10.1038/S41598-019-43295-3  1
2019 Beane JE, Mazzilli SA, Campbell JD, Duclos G, Krysan K, Moy C, Perdomo C, Schaffer M, Liu G, Zhang S, Liu H, Vick J, Dhillon SS, Platero SJ, Dubinett SM, ... ... Spira AE, et al. Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions. Nature Communications. 10: 1856. PMID 31015447 DOI: 10.1038/S41467-019-09834-2  1
2019 Kadara H, Sivakumar S, Jakubek Y, San Lucas FA, Lang W, McDowell T, Weber Z, Behrens C, Davies GE, Kalhor N, Moran C, El-Zein R, Mehran R, Swisher SG, Wang J, ... ... Spira AE, et al. Driver Mutations in Normal Airway Epithelium Elucidate Spatiotemporal Resolution of Lung Cancer. American Journal of Respiratory and Critical Care Medicine. PMID 30896962 DOI: 10.1164/Rccm.201806-1178Oc  1
2019 Faiz A, Steiling K, Roffel MP, Postma DS, Spira A, Lenburg ME, Borggrewe M, Eijgenraam TR, Jonker MR, Koppelman GH, Pouwels SD, Liu G, Alekseyev YO, Lam S, Hiemstra PS, et al. Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in Chronic Obstructive Pulmonary Disease. The European Respiratory Journal. PMID 30846474 DOI: 10.1183/13993003.01202-2018  1
2019 Billatos E, Duan F, Moses E, Marques H, Mahon I, Dymond L, Apgar C, Aberle D, Washko G, Spira A. Detection of early lung cancer among military personnel (DECAMP) consortium: study protocols. Bmc Pulmonary Medicine. 19: 59. PMID 30845938 DOI: 10.1186/S12890-019-0825-7  1
2019 Teixeira VH, Pipinikas CP, Pennycuick A, Lee-Six H, Chandrasekharan D, Beane J, Morris TJ, Karpathakis A, Feber A, Breeze CE, Ntolios P, Hynds RE, Falzon M, Capitanio A, Carroll B, ... ... Spira A, et al. Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions. Nature Medicine. PMID 30664780 DOI: 10.1038/S41591-018-0323-0  1
2019 xu f, Tanabe N, Macdonough J, Vasilescu D, Ikezoe K, Kinose D, Ng K, Verleden S, Vanaudenaerde B, Verschakelen J, Cooper J, Lenburg M, Spira A, Ng R, Hogg J. The transition from normal lung anatomy to Fibrosis in IPF European Respiratory Journal. DOI: 10.1183/13993003.Congress-2019.Oa470  1
2019 Mazzilli SA, Hijazi K, Pihl R, Belkina A, Zhang X, Liu G, Lenburg M, Stevenson C, Spira A, Beane J. Abstract 660: The molecular characterization of a murine lung premalignancy model for lung cancer interception Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-660  1
2019 Zhang J, Burks E, Beane J, Sullivan T, Liu G, Dubinett S, Lenburg M, Spira A. Abstract 3530: Gene expression alterations associated with histologic aggressiveness in stage I lung adenocarcinomas Cancer Research. 79: 3530-3530. DOI: 10.1158/1538-7445.Sabcs18-3530  1
2019 Sofer T, Li R, Joehanes R, Lin H, Gower A, Punjabi N, Mehra R, Patel S, Quan S, Liu Y, Gharib S, Levy D, Spira A, Redline S, Gottlieb D. 0021 Lower Oxygen Saturation During Sleep Is Associated With Reduced Expressions Of Cd1d And Rab20 That Is Potentially Reversed By CPAP Therapy Sleep. 42: A8-A9. DOI: 10.1093/Sleep/Zsz067.020  0.01
2019 Lamb C, Hospital L, Center M, Ding J, Saberi S, Pankratz D, Babiarz J, Chamberlin J, Bhorade S, Wilde J, Walsh P, Lofaro L, Huang J, Stevenson C, Lenburg M, ... ... Spira A, et al. LUNG CANCER DETECTION VIA WHOLE-TRANSCRIPTOME RNA SEQUENCING OF NASAL EPITHELIUM Chest. 156: A1091-A1092. DOI: 10.1016/J.Chest.2019.08.1005  0.01
2018 Wu AC, Kiley JP, Noel PJ, Amur S, Burchard EG, Clancy JP, Galanter J, Inada M, Jones TK, Kropski JA, Loyd JE, Nogee LM, Raby BA, Rogers AJ, Schwartz DA, ... ... Spira A, et al. Current Status and Future Opportunities in Lung Precision Medicine Research with a Focus on Biomarkers. An American Thoracic Society/National Heart, Lung, and Blood Institute Research Statement. American Journal of Respiratory and Critical Care Medicine. 198: e116-e136. PMID 30640517 DOI: 10.1164/Rccm.201810-1895St  0.04
2018 Seijo LM, Peled N, Ajona D, Boeri M, Field JK, Sozzi G, Pio R, Zulueta JJ, Spira A, Massion PP, Mazzone PJ, Montuenga LM. Biomarkers in Lung Cancer Screening: Achievements, Promises, and Challenges. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. PMID 30529598 DOI: 10.1016/J.Jtho.2018.11.023  1
2018 Bals R, Boyd J, Esposito S, Foronjy R, Hiemstra PS, Jiménez-Ruiz CA, Katsaounou P, Lindberg A, Metz C, Schober W, Spira A, Blasi F. Electronic Cigarettes - Task Force report from the European Respiratory Society. The European Respiratory Journal. PMID 30464018 DOI: 10.1183/13993003.01151-2018  1
2018 Khalil A, Dekmak B, Boulos F, Kantrowitz J, Spira A, Fujimoto J, Kadara H, El-Hachem N, Nemer G. Transcriptomic Alterations in Lung Adenocarcinoma Unveil New Mechanisms Targeted by the Subfamily of Tumor Suppressor Genes. Frontiers in Oncology. 8: 482. PMID 30425966 DOI: 10.3389/Fonc.2018.00482  1
2018 Christenson SA, van den Berge M, Faiz A, Imkamp K, Bhakta N, Bonser LR, Zlock LT, Barjaktarevic IZ, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Comellas AP, Curtis JL, Han MK, ... ... Spira A, et al. An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup. The Journal of Clinical Investigation. PMID 30383540 DOI: 10.1172/Jci121087  1
2018 Tasena H, Faiz A, Timens W, Noordhoek J, Hylkema MN, Gosens R, Hiemstra PS, Spira A, Postma DS, Tew GW, Grimbaldeston MA, van den Berge M, Heijink IH, Brandsma CA. microRNA-mRNA regulatory networks underlying chronic mucus hypersecretion in COPD. The European Respiratory Journal. PMID 30072506 DOI: 10.1183/13993003.01556-2017  1
2018 Billatos E, Faiz A, Gesthalter YO, LeClerc A, Alekseyev Y, Zhang X, Liu G, Ten Hacken NHT, Heijink I, Timens W, Brandsma CA, Postma DS, van den Berge M, Spira A, Lenburg ME. The Impact of Acute Exposure to Cigarette Smoke on Airway Gene Expression. Physiological Genomics. PMID 29932825 DOI: 10.1152/Physiolgenomics.00092.2017  1
2018 Reyfman PA, Washko GR, Dransfield MT, Spira A, Han MK, Kalhan R. Defining Impaired Respiratory Health: A Paradigm Shift for Pulmonary Medicine. American Journal of Respiratory and Critical Care Medicine. PMID 29624449 DOI: 10.1164/Rccm.201801-0120Pp  0.08
2018 Spira A, Coleman D. Impact of an Interdisciplinary Computational Research Section in a Department of Medicine: an Eight-Year Perspective. The American Journal of Medicine. PMID 29601802 DOI: 10.1016/J.Amjmed.2018.03.008  0.01
2018 Pine PS, Lund SP, Parsons JR, Vang LK, Mahabal AA, Cinquini L, Kelly SC, Kincaid H, Crichton DJ, Spira A, Liu G, Gower AC, Pass HI, Goparaju C, Dubinett SM, et al. Summarizing performance for genome scale measurement of miRNA: reference samples and metrics. Bmc Genomics. 19: 180. PMID 29510677 DOI: 10.1186/S12864-018-4496-1  1
2018 Billatos E, Vick JL, Lenburg ME, Spira AE. The Airway Transcriptome as a Biomarker for Early Lung Cancer Detection. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29463557 DOI: 10.1158/1078-0432.Ccr-16-3187  1
2018 Kantrowitz J, Sinjab A, Xu L, McDowell TL, Sivakumar S, Lang W, Nunomura-Nakamura S, Fukuoka J, Nemer G, Darwiche N, Chami H, Tfayli A, Wistuba II, Scheet P, Fujimoto J, ... Spira AE, et al. Genome-wide gene expression changes in the normal-appearing airway during the evolution of smoking-associated lung adenocarcinoma. Cancer Prevention Research (Philadelphia, Pa.). PMID 29382653 DOI: 10.1158/1940-6207.Capr-17-0295  1
2018 Faiz A, Billatos E, Lenburg M, Spira A, Vonk J, Boezen M, Heijink I, Berge MVD. SNPs which influence the transcriptional response to acute smoke exposure are associated with long term lung function decline in smokers European Respiratory Journal. 52. DOI: 10.1183/13993003.Congress-2018.Pa927  1
2018 Steiling K, Zhang J, Sands J, Sullivan T, Billatos E, Moses E, Liu G, Lamb C, McKee B, Lenburg M, Spira A, Rieger-Christ K. Abstract A15: Nasal gene expression for the diagnostic evaluation of indeterminate pulmonary nodules within a screening population Clinical Cancer Research. 24. DOI: 10.1158/1557-3265.Aacriaslc18-A15  1
2018 Beane JE, Mazzilli S, Tassinari A, Campbell J, Moy C, Schaffer M, Perdomo C, Jenkins D, Pine MB, Liu G, Zhang S, Lin H, Vick J, Johnson E, Platero S, ... ... Spira A, et al. Abstract A05: Bronchial premalignant lesions have distinct molecular subtypes associated with future histologic progression Clinical Cancer Research. 24. DOI: 10.1158/1557-3265.Aacriaslc18-A05  1
2018 Mazzilli S, Zhang S, Liu G, Lenburg M, Spira A, Beane J. Abstract B18: The carcinogen-induced NTCU model: A preclinical mouse model for lung cancer interception Cancer Research. 78. DOI: 10.1158/1538-7445.Mousemodels17-B18  1
2018 Shi X, Duclos G, Campbell J, Gesthalter Y, Autissier P, Dumas YM, Terrano R, Liu G, Lenburg ME, Spira A, Beane J. Abstract 2534: Single-cell RNA sequencing reveals lung cancer-associated alterations in bronchial cell subpopulations in the mainstem bronchus Cancer Research. 78: 2534-2534. DOI: 10.1158/1538-7445.Am2018-2534  1
2018 Shi X, Billatos E, Zhang J, Beane J, Moses E, Liu G, Stevenson C, Lenburg ME, Spira A. Abstract 2531: Diagnostic evaluation of indeterminate pulmonary nodules via rna-seq of bronchial epithelium Cancer Research. 78: 2531-2531. DOI: 10.1158/1538-7445.Am2018-2531  1
2018 LEE H, BHADRA K, WHITTEN P, ESTERLE M, BERNSTEIN M, DOTSON T, BENZAQUEN S, MAZZONE P, GORDON J, HOGARTH D, JOHNSON M, HUANG J, GRISCOM B, LOFARO L, KENNEDY G, ... SPIRA A, et al. CLINICAL UTILITY OF A BRONCHIAL GENOMIC CLASSIFIER FOR LUNG CANCER DETECTION: RESULTS FROM A MULTICENTER PROSPECTIVE REGISTRY Chest. 154: 597A-599A. DOI: 10.1016/J.Chest.2018.08.540  0.01
2017 Boudewijn IM, Faiz A, Steiling K, van der Wiel E, Telenga ED, Hoonhorst SJM, Ten Hacken NHT, Brandsma CA, Kerstjens HAM, Timens W, Heijink IH, Jonker MR, de Bruin HG, Sebastiaan Vroegop J, Pasma HR, ... ... Spira A, et al. Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression. Respiratory Research. 18: 213. PMID 29268739 DOI: 10.1186/S12931-017-0696-5  1
2017 Dubinett SM, Spira AE. Impact of COPD on Immune-based Treatment for Lung Cancer: Moving Towards Disease Interception. American Journal of Respiratory and Critical Care Medicine. PMID 29072842 DOI: 10.1164/Rccm.201710-2065Ed  1
2017 Khalil AA, Sivakumar S, Lucas FAS, McDowell T, Lang W, Tabata K, Fujimoto J, Yatabe Y, Spira A, Scheet P, Nemer G, Kadara H. TBX2 subfamily suppression in lung cancer pathogenesis: a high-potential marker for early detection. Oncotarget. 8: 68230-68241. PMID 28978111 DOI: 10.18632/Oncotarget.19938  1
2017 Tessema M, Yingling CM, Picchi MA, Wu G, Ryba T, Lin Y, Bungum AO, Edell ES, Spira A, Belinsky SA. ANK1 Methylation Regulates Expression of MicroRNA-486-5p and Discriminates Lung tumors by Histology and Smoking Status. Cancer Letters. PMID 28965852 DOI: 10.1016/J.Canlet.2017.09.038  1
2017 Sivakumar S, San Lucas FA, McDowell TL, Lang W, Xu L, Fujimoto J, Zhang J, Futreal PA, Fukuoka J, Yatabe Y, Dubinett SM, Spira AE, Fowler J, Hawk ET, Wistuba II, et al. Genomic landscape of atypical adenomatous hyperplasia reveals divergent modes to lung adenocarcinoma. Cancer Research. PMID 28951454 DOI: 10.1158/0008-5472.Can-17-1605  1
2017 Ong J, Timens W, Rajendran V, Algra A, Spira A, Lenburg ME, Campbell JD, van den Berge M, Postma DS, van den Berg A, Kluiver J, Brandsma CA. Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts. Plos One. 12: e0183815. PMID 28910321 DOI: 10.1371/Journal.Pone.0183815  1
2017 Pavel AB, Campbell JD, Liu G, Elashoff DA, Dubinett SM, Smith K, Whitney D, Lenburg ME, Spira AE. Alterations in bronchial airway microRNA expression for lung cancer detection. Cancer Prevention Research (Philadelphia, Pa.). PMID 28877936 DOI: 10.1158/1940-6207.Capr-17-0098  1
2017 Suzuki M, Sze MA, Campbell JD, Brothers JF, Lenburg ME, McDonough JE, Elliott WM, Cooper JD, Spira A, Hogg JC. The cellular and molecular determinants of emphysematous destruction in COPD. Scientific Reports. 7: 9562. PMID 28842670 DOI: 10.1038/S41598-017-10126-2  1
2017 Beane J, Campbell JD, Lel J, Vick J, Spira A. Genomic approaches to accelerate cancer interception. The Lancet. Oncology. 18: e494-e502. PMID 28759388 DOI: 10.1016/S1470-2045(17)30373-X  1
2017 Beane J, Mazzilli SA, Tassinari AM, Liu G, Zhang X, Liu H, Dy Buncio A, Dhillon SS, Platero SJ, Lenburg ME, Reid ME, Lam S, Spira AE. Detecting the Presence and Progression of Premalignant Lung Lesions via Airway Gene Expression. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28533227 DOI: 10.1158/1078-0432.Ccr-16-2540  1
2017 Gold DR, Adamkiewicz G, Arshad SH, Celedón JC, Chapman MD, Chew GL, Cook DN, Custovic A, Gehring U, Gern JE, Johnson CC, Kennedy S, Koutrakis P, Leaderer B, Mitchell H, ... ... Spira A, et al. NIAID, NIEHS, NHLBI, MCAN Workshop Report: The Indoor Environment and Childhood Asthma: Implications for Home Environmental Intervention in Asthma Prevention and Management. The Journal of Allergy and Clinical Immunology. PMID 28502823 DOI: 10.1016/J.Jaci.2017.04.024  1
2017 Vachani A, Sequist LV, Spira A. AJRCCM: 100-Year Anniversary. The Shifting Landscape for Lung Cancer: Past, Present, and Future. American Journal of Respiratory and Critical Care Medicine. 195: 1150-1160. PMID 28459327 DOI: 10.1164/Rccm.201702-0433Ci  1
2017 Obeidat M, Nie Y, Fishbane N, Li X, Bossé Y, Joubert P, Nickle DC, Hao K, Postma DS, Timens W, Sze MA, Shannon CP, Hollander Z, Ng RT, McManus B, ... ... Spira A, et al. Integrative Genomics of Emphysema Associated Genes Reveals Potential Disease Biomarkers. American Journal of Respiratory Cell and Molecular Biology. PMID 28459279 DOI: 10.1165/Rcmb.2016-0284Oc  1
2017 Spira A, Yurgelun MB, Alexandrov L, Rao A, Bejar R, Polyak K, Giannakis M, Shilatifard A, Finn OJ, Dhodapkar M, Kay NE, Braggio E, Vilar E, Mazzilli SA, Rebbeck TR, et al. Precancer Atlas to Drive Precision Prevention Trials. Cancer Research. 77: 1510-1541. PMID 28373404 DOI: 10.1158/0008-5472.Can-16-2346  1
2017 Boudewijn IM, Faiz A, Steiling K, Wiel Evd, Telenga E, Hoonhorst S, Hacken Nt, Brandsma C, Kerstjens H, Timens W, Heijink I, Jonker M, Bruin Hd, Vroegop S, Pasma H, ... ... Spira A, et al. A nasal gene expression profile differentiates individuals with and without COPD and overlaps bronchial gene expression European Respiratory Journal. 50. DOI: 10.1183/1393003.Congress-2017.Pa4470  1
2017 Ong J, Timens W, Rajendran V, Algra A, Spira A, Lenburg M, Campbell J, Berge Mvd, Postma D, Berg Avd, Kluiver J, Brandsma C. Target gene identification of TGF-beta-induced miR-455-3p and miR-21-3p in lung fibroblasts European Respiratory Journal. 50. DOI: 10.1183/1393003.Congress-2017.Pa1025  1
2017 Beane JE, Mazzilli S, Campbell J, Moy C, Schaffer M, Perdomo C, Jenkins D, Liu G, Zhang S, Liu H, Vick J, Johnson E, Platero S, Lenburg M, Reid M, ... ... Spira A, et al. Abstract 5002: Premalignant squamous cell lung carcinoma lesions have distinct molecular subtypes associated with histologic progression Cancer Research. 77: 5002-5002. DOI: 10.1158/1538-7445.Am2017-5002  1
2017 Drizik EI, Corbett S, Vermeulen R, Dai Y, Hu W, Lenburg M, Ren D, Duan H, Niu Y, Xu J, Fu W, Meliefste K, Zhou B, Yang J, Ye M, ... ... Spira A, et al. Abstract 4256: Impact of diesel engine exhaust exposure on the airway transcriptome Cancer Research. 77: 4256-4256. DOI: 10.1158/1538-7445.Am2017-4256  1
2017 Campbell J, Zhang X, Dhillon SS, Perdomo C, Mazzilli S, Geshalter Y, Liu G, Zhang S, Lin H, Vick J, Moy C, Monti S, Johnson E, Meyerson M, Dubinett S, ... ... Spira A, et al. Abstract 3259: The genomic landscape of premalignant lung squamous cell carcinoma lesions Cancer Research. 77: 3259-3259. DOI: 10.1158/1538-7445.Am2017-3259  1
2017 Duclos GE, Campbell JD, Gesthalter Y, Autissier P, Dumas YM, Terrano R, Liu G, Lenburg ME, Spira A, Beane J. Abstract 1433: Single cell RNA sequencing reveals smoking-associated alterations in bronchial airway epithelial subpopulations Cancer Research. 77: 1433-1433. DOI: 10.1158/1538-7445.Am2017-1433  1
2017 Mazzilli SA, Tassinari A, Xiao X, Liu G, Dhillon S, Johnson C, Reid M, Lenburg M, Spira A, Beane J. Abstract 1252: A pre-clinical model for lung cancer interception: gene expression similarities between human and mouse bronchial premalignant lesions Cancer Research. 77: 1252-1252. DOI: 10.1158/1538-7445.Am2017-1252  1
2017 Gower AC, Spira A, Lenburg ME. 2356 Journal of Clinical and Translational Science. 1: 16-16. DOI: 10.1017/cts.2017.71  0.01
2017 Sivakumar S, San Lucas F, McDowell T, Lang W, Xu L, Fujimoto J, Zhang J, Wistuba I, Futreal F, Fukuoka J, Yatabe Y, Dubinett S, Spira A, Fowler J, Hawk E, et al. Genomic Landscape of Atypical Adenomatous Hyperplasia and Their Progression to Lung Adenocarcinomas Journal of Thoracic Oncology. 12: S1546. DOI: 10.1016/J.Jtho.2017.06.061  0.01
2017 Lee H, Whitten P, Bhadra K, Dotson T, Hogarth D, Benzaquen S, Pritchett M, Gordon J, Bedekar A, Esterle M, Smith K, Bianchi P, Lenburg M, Spira A. Prospective Utility of a Bronchial Genomic Classifier for Lung Cancer Detection: Interim Results From a Multicenter Prospective Registry Chest. 152: A625. DOI: 10.1016/J.Chest.2017.08.658  0.01
2016 Rahman SM, Ji X, Zimmerman LJ, Li M, Harris BK, Hoeksema MD, Trenary IA, Zou Y, Qian J, Slebos RJ, Beane J, Spira A, Shyr Y, Eisenberg R, Liebler DC, et al. The airway epithelium undergoes metabolic reprogramming in individuals at high risk for lung cancer. Jci Insight. 1: e88814. PMID 27882349 DOI: 10.1172/Jci.Insight.88814  1
2016 Vasilescu DM, Phillion AB, Tanabe N, Kinose D, Paige DF, Kantrowitz JJ, Liu G, Liu H, Fishbane N, Verleden SE, Vanaudenaerde BM, Lenburg ME, Stevenson CS, Spira A, Cooper JD, et al. Non-destructive cryo micro CT imaging enables structural and molecular analysis of human lung tissue. Journal of Applied Physiology (Bethesda, Md. : 1985). jap.00838.2016. PMID 27856720 DOI: 10.1152/Japplphysiol.00838.2016  1
2016 Moses E, Wang T, Corbett S, Jackson GR, Drizik E, Perdomo C, Perdomo C, Kleerup E, Brooks D, O'Connor G, Dubinett S, Hayden P, Lenburg ME, Spira A. Molecular impact of electronic cigarette aerosol exposure in human bronchial epithelium. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27701119 DOI: 10.1093/Toxsci/Kfw198  1
2016 Lam S, Mandrekar SJ, Gesthalter Y, Allen Ziegler KL, Seisler DK, Midthun DE, Mao JT, Aubry MC, McWilliams A, Sin DD, Shaipanich T, Liu G, Johnson E, Bild AH, Lenburg ME, ... ... Spira AE, et al. A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia. Cancer Prevention Research (Philadelphia, Pa.). PMID 27658890 DOI: 10.1158/1940-6207.Capr-15-0254  1
2016 Spira A, Disis ML, Schiller JT, Vilar E, Rebbeck TR, Bejar R, Ideker T, Arts J, Yurgelun MB, Mesirov JP, Rao A, Garber J, Jaffee EM, Lippman SM. Leveraging premalignant biology for immune-based cancer prevention. Proceedings of the National Academy of Sciences of the United States of America. PMID 27638202 DOI: 10.1073/Pnas.1608077113  1
2016 Spira A, Halmos B, Powell CA. Update in Lung Cancer 2015. American Journal of Respiratory and Critical Care Medicine. 194: 661-671. PMID 27628077 DOI: 10.1164/Rccm.201604-0898Up  1
2016 Chitsazzadeh V, Coarfa C, Drummond JA, Nguyen T, Joseph A, Chilukuri S, Charpiot E, Adelmann CH, Ching G, Nguyen TN, Nicholas C, Thomas VD, Migden M, MacFarlane D, Thompson E, ... ... Spira A, et al. Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates. Nature Communications. 7: 12601. PMID 27574101 DOI: 10.1038/Ncomms12601  0.32
2016 Tellez CS, Juri DE, Do KC, Picchi MA, Wang T, Liu G, Spira AE, Belinsky SA. MiR-196b is epigenetically silenced during the pre-malignant stage of lung carcinogenesis. Cancer Research. PMID 27302168 DOI: 10.1158/0008-5472.CAN-15-3367  1
2016 Dennis KK, Auerbach SS, Balshaw DM, Cui Y, Fallin MD, Smith MT, Spira A, Sumner S, Miller GW. The Importance of the Biological Impact of Exposure to the Concept of the Exposome. Environmental Health Perspectives. PMID 27258438 DOI: 10.1289/Ehp140  1
2016 Jakubek Y, Lang W, Vattathil S, Garcia M, Xu L, Huang L, Yoo SY, Shen L, Lu W, Chow CW, Weber Z, Davies G, Huang J, Behrens C, Kalhor N, ... Spira AE, et al. Genomic landscape established by allelic imbalance in the cancerization field of a normal appearing airway. Cancer Research. PMID 27216194 DOI: 10.1158/0008-5472.Can-15-3064  1
2016 Ferguson JS, Van Wert R, Choi Y, Rosenbluth MJ, Smith KP, Huang J, Spira A. Impact of a bronchial genomic classifier on clinical decision making in patients undergoing diagnostic evaluation for lung cancer. Bmc Pulmonary Medicine. 16: 66. PMID 27184093 DOI: 10.1186/S12890-016-0217-1  1
2016 Kusko RL, Brothers Ii JF, Tedrow J, Pandit K, Huleihel L, Perdomo C, Liu G, Juan-Guardela B, Kass D, Zhang S, Lenburg M, Martinez F, Quackenbush J, Sciurba F, Limper A, ... ... Spira A, et al. Integrated Genomics Reveals Convergent Transcriptomic Networks Underlying COPD and IPF. American Journal of Respiratory and Critical Care Medicine. PMID 27104832 DOI: 10.1164/Rccm.201510-2026Oc  1
2016 Kadara H, Scheet P, Wistuba II, Spira AE. Early events in the molecular pathogenesis of lung cancer. Cancer Prevention Research (Philadelphia, Pa.). PMID 27006378 DOI: 10.1158/1940-6207.Capr-15-0400  1
2016 Piccolo SR, Hoffman LM, Conner T, Shrestha G, Cohen AL, Marks JR, Neumayer LA, Agarwal CA, Beckerle MC, Andrulis IL, Spira AE, Moos PJ, Buys SS, Johnson WE, Bild AH. Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility. Molecular Systems Biology. 12: 860. PMID 26969729 DOI: 10.15252/Msb.20156506  1
2016 Petrylak DP, Tagawa ST, Kohli M, Eisen A, Canil C, Sridhar SS, Spira A, Yu EY, Burke JM, Shaffer D, Pan CX, Kim JJ, Aragon-Ching JB, Quinn DI, Vogelzang NJ, et al. Docetaxel As Monotherapy or Combined With Ramucirumab or Icrucumab in Second-Line Treatment for Locally Advanced or Metastatic Urothelial Carcinoma: An Open-Label, Three-Arm, Randomized Controlled Phase II Trial. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. PMID 26926681 DOI: 10.1200/JCO.2015.65.0218  1
2016 Vachani A, Whitney DH, Parsons EC, Lenburg M, Ferguson JS, Silvestri GA, Spira A. Clinical Utility of a Bronchial Genomic Classifier in Patients with Suspected Lung Cancer. Chest. PMID 26896702 DOI: 10.1016/J.Chest.2016.02.636  1
2016 Campbell JD, Mazzilli SA, Reid ME, Dhillon SS, Platero S, Beane J, Spira AE. The Case for a Pre-Cancer Genome Atlas (PCGA). Cancer Prevention Research (Philadelphia, Pa.). 9: 119-24. PMID 26839336 DOI: 10.1158/1940-6207.Capr-16-0024  1
2016 Kensler TW, Spira A, Garber JE, Szabo E, Lee JJ, Dong Z, Dannenberg AJ, Hait WN, Blackburn E, Davidson NE, Foti M, Lippman SM. Transforming Cancer Prevention through Precision Medicine and Immune-oncology. Cancer Prevention Research (Philadelphia, Pa.). 9: 2-10. PMID 26744449 DOI: 10.1158/1940-6207.Capr-15-0406  1
2016 Faner R, Cruz T, Casserras T, López-Giraldo A, Noell G, Coca I, Tal-Singer R, Miller B, Rodriguez-Roisin R, Spira A, Kalko SG, Agusti A. Network Analysis of Lung Transcriptomics Reveals a Distinct B Cell Signature in Emphysema. American Journal of Respiratory and Critical Care Medicine. PMID 26735770 DOI: 10.1164/Rccm.201507-1311Oc  1
2016 Faiz A, Postma D, Koppelman G, Hiemstra P, Sterk P, Timens W, Steiling K, Spira A, Heijink I, Berge Mvd. LSC Abstract – Inducible expression quantitative trait loci: A novel method to identifying genetic variants associated with corticosteroid responsiveness in COPD European Respiratory Journal. 48: 136. DOI: 10.1183/13993003.Congress-2016.Pp136  1
2016 Imkamp K, Faiz A, Wiel Evd, Boudewijn I, Koppelman G, Brandsma C, Kerstjens H, Timens W, Vroegop S, Pasma H, Boersma W, Wielders P, Elshout Fvd, Mansour K, Steiling K, ... Spira A, et al. Effects of ICS/LABA treatment on hyperinflation and genome wide gene-expression in upper airway epithelium in severe COPD European Respiratory Journal. 48. DOI: 10.1183/13993003.Congress-2016.Pa1203  1
2016 Faiz A, Postma DS, Koppelman GH, Hiemstra PS, Sterk PJ, Timens W, Steiling K, Spira A, Heijink IH, Berge Mvd. FKBP5 a candidate for corticosteroid insensitivity in COPD European Respiratory Journal. 48. DOI: 10.1183/13993003.Congress-2016.Oa1779  1
2016 Tellez CS, Juri DE, Do K, Picchi MA, Wang T, Liu G, Spira A, Belinsky SA. Abstract 958: MiR-196b is an epigenetically silenced tumor suppressor for lung cancer Cancer Research. 76: 958-958. DOI: 10.1158/1538-7445.Am2016-958  1
2016 Mazzilli SA, Tassinari A, Gethalter Y, Lui G, Pine M, Lam S, Reid M, Platero S, Lenburg M, Spira A, Beane J. Abstract 896: The airway field of injury reflects gene expression changes associated with the presence of lung squamous premalignant lesions Cancer Research. 76: 896-896. DOI: 10.1158/1538-7445.Am2016-896  1
2016 Campbell JD, Perdomo C, Mazzilli S, Geshalter Y, Dhillon SS, Liu G, Zhang S, Lin H, Vick J, Moy C, Johnson E, Meyerson M, Platero S, Lenburg M, Reid M, ... Spira A, et al. Abstract 895: Genomic characterization of premalignant lung squamous cell carcinoma lesions Cancer Research. 76: 895-895. DOI: 10.1158/1538-7445.Am2016-895  1
2016 Moses E, Wang T, Jackson GR, Corbett S, Drizik E, Brooks D, O’Connor G, Perdomo C, Dubinett S, Hayden P, Lenburg ME, Spira A. Abstract 4502: Molecular impact of in vitro exposure to electronic cigarette vapor in human bronchial epithelium Cancer Research. 76: 4502-4502. DOI: 10.1158/1538-7445.Am2016-4502  1
2016 Pavel AB, Campbell J, Liu G, Zhang S, Liu H, Xiao J, Porta K, Whitney D, Dubinett S, Elashoff D, Lenburg M, Spira A. Abstract 1954: microRNA expression in bronchial epithelium for lung cancer detection Cancer Research. 76: 1954-1954. DOI: 10.1158/1538-7445.Am2016-1954  1
2016 Mascaux C, Angelova M, Beane J, Hijazi K, Antoine G, Gallo KW, Ninane V, Burny A, Sculier J, Spira A, Galon J. Abstract 1419: Characterization of the evolution of immune response in lung squamous carcinogenesis Cancer Research. 76: 1419-1419. DOI: 10.1158/1538-7445.Am2016-1419  1
2016 Park SJ, Walser TC, Tran LM, Perdomo C, Wang T, Hong L, Pagano P, Li R, Jing Z, Liclican E, Larsen JE, Krysan K, Fishbein MC, Minna JD, Lenburg ME, ... Spira A, et al. The biological impact of e-cigarettes on airway epithelial cell transformation and gene expression Journal of Thoracic Oncology. 11: S35-S36. DOI: 10.1016/J.Jtho.2015.12.060  0.01
2016 Van Wert R, Ferguson J, Choi Y, Rosenbluth M, Spira A. Impact of a Bronchial Genomic Classifier for Lung Cancer on Reducing Invasive Procedure Recommendations Across Variations in Pulmonology Practices Chest. 150: 732A. DOI: 10.1016/j.chest.2016.08.827  0.01
2016 Reed E, Bray D, Lam S, van den Berge M, Liu G, Zhang X, Alekseyev Y, Spira A, Lenburg M, Steiling K. Data-Driven Identification of Novel Molecular Subclasses of COPD Chest. 150: 916A. DOI: 10.1016/J.Chest.2016.08.1016  0.04
2016 Becker E, Lam S, van den Berge M, Liu G, Zhang X, Alekseyev Y, Spira A, Lenburg M, Steiling K. Predicting Lung Function Decline in COPD Using Bronchial Airway Gene Expression Chest. 150: 912A. DOI: 10.1016/J.Chest.2016.08.1012  0.01
2015 Piccolo SR, Andrulis IL, Cohen AL, Conner T, Moos PJ, Spira AE, Buys SS, Johnson WE, Bild AH. Gene-expression patterns in peripheral blood classify familial breast cancer susceptibility. Bmc Medical Genomics. 8: 72. PMID 26538066 DOI: 10.1186/s12920-015-0145-6  1
2015 Wang TW, Vermeulen RC, Hu W, Liu G, Xiao X, Alekseyev Y, Xu J, Reiss B, Steiling K, Downward GS, Silverman DT, Wei F, Wu G, Li J, Lenburg ME, ... ... Spira A, et al. Gene-expression profiling of buccal epithelium among nonsmoking women exposed to household air pollution from smoky coal. Carcinogenesis. PMID 26468118 DOI: 10.1093/Carcin/Bgv150  1
2015 Spira A, Halmos B, Powell CA. Update in Lung Cancer 2014. American Journal of Respiratory and Critical Care Medicine. 192: 283-94. PMID 26230235 DOI: 10.1164/Rccm.201504-0756Up  1
2015 Silvestri GA, Vachani A, Whitney D, Elashoff M, Porta Smith K, Ferguson JS, Parsons E, Mitra N, Brody J, Lenburg ME, Spira A. A Bronchial Genomic Classifier for the Diagnostic Evaluation of Lung Cancer. The New England Journal of Medicine. 373: 243-51. PMID 25981554 DOI: 10.1056/Nejmoa1504601  1
2015 Sze MA, Dimitriu PA, Suzuki M, McDonough JE, Campbell JD, Brothers JF, Erb-Downward JR, Huffnagle GB, Hayashi S, Elliott WM, Cooper J, Sin DD, Lenburg ME, Spira A, Mohn WW, et al. The Host Response to the Lung Microbiome in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. PMID 25945594 DOI: 10.1164/Rccm.201502-0223Oc  1
2015 Whitney DH, Elashoff MR, Porta-Smith K, Gower AC, Vachani A, Ferguson JS, Silvestri GA, Brody JS, Lenburg ME, Spira A. Derivation of a bronchial genomic classifier for lung cancer in a prospective study of patients undergoing diagnostic bronchoscopy. Bmc Medical Genomics. 8: 18. PMID 25944280 DOI: 10.1186/S12920-015-0091-3  1
2015 Grayson PC, Steiling K, Platt M, Berman JS, Zhang X, Xiao J, Alekseyev YO, Liu G, Monach PA, Kaplan MJ, Spira A, Merkel PA. Brief Report: Defining the Nasal Transcriptome in Granulomatosis With Polyangiitis (Wegener's). Arthritis & Rheumatology (Hoboken, N.J.). 67: 2233-9. PMID 25939343 DOI: 10.1002/Art.39185  1
2015 Wilson AA, Ying L, Liesa M, Segeritz CP, Mills JA, Shen SS, Jean J, Lonza GC, Liberti DC, Lang AH, Nazaire J, Gower AC, Müeller FJ, Mehta P, Ordóñez A, ... ... Spira A, et al. Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells. Stem Cell Reports. 4: 873-85. PMID 25843048 DOI: 10.1016/J.Stemcr.2015.02.021  1
2015 Maxwell EK, Campbell JD, Spira A, Baxevanis AD. SubmiRine: assessing variants in microRNA targets using clinical genomic data sets. Nucleic Acids Research. 43: 3886-98. PMID 25813044 DOI: 10.1093/Nar/Gkv256  1
2015 Gesthalter YB, Vick J, Steiling K, Spira A. Translating the transcriptome into tools for the early detection and prevention of lung cancer. Thorax. 70: 476-81. PMID 25628310 DOI: 10.1136/Thoraxjnl-2014-206605  1
2015 Christenson SA, Steiling K, van den Berge M, Hijazi K, Hiemstra PS, Postma DS, Lenburg ME, Spira A, Woodruff PG. Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine. 191: 758-66. PMID 25611785 DOI: 10.1164/Rccm.201408-1458Oc  1
2015 Yoo S, Takikawa S, Geraghty P, Argmann C, Campbell J, Lin L, Huang T, Tu Z, Foronjy RF, Feronjy R, Spira A, Schadt EE, Powell CA, Zhu J. Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD. Plos Genetics. 11: e1004898. PMID 25569234 DOI: 10.1371/Journal.Pgen.1004898  1
2015 Campbell JD, Liu G, Luo L, Xiao J, Gerrein J, Juan-Guardela B, Tedrow J, Alekseyev YO, Yang IV, Correll M, Geraci M, Quackenbush J, Sciurba F, Schwartz DA, Kaminski N, ... ... Spira A, et al. Assessment of microRNA differential expression and detection in multiplexed small RNA sequencing data. Rna (New York, N.Y.). 21: 164-71. PMID 25519487 DOI: 10.1261/Rna.046060.114  1
2015 Billatos E, Gesthalter Y, ten Hacken N, Postma D, Heijink I, Timens W, Brandsma C, Faiz A, Berge M, Lenburg M, Spira A. The Impact of Acute Smoking on Airway Gene-Expression Chest. 148: 746A. DOI: 10.1378/Chest.2280491  0.01
2015 Vachani A, Silvestri G, Whitney D, Ferguson J, Porta K, Parsons E, Brody J, Lenburg M, Spira A. Prospective Validation of a Bronchial Genomic Classifier for Lung Cancer in Patients Undergoing Diagnostic Bronchoscopy: The AEGIS Trials Chest. 148: 544A. DOI: 10.1378/Chest.2280365  0.01
2015 Vachani A, Parsons E, Ferguson J, Whitney D, Porta K, Rosenbluth M, Silvestri G, Spira A. Clinical Utility of a Bronchial Genomic Classifier: An Analysis of Invasive Procedure Utilization in the AEGIS Trials Chest. 148: 545A. DOI: 10.1378/chest.2270755  0.01
2015 Faiz A, Borggrewe M, Postma D, Steiling K, Spira A, Lenburg M, Jonker M, Koppelman G, Hiemstra P, Sterk P, Timens W, Brandsma C, Berge MVd, Heijink I. MiR-320d: A novel anti-inflammatory miRNA up regulated by corticosteroids European Respiratory Journal. 46. DOI: 10.1183/13993003.Congress-2015.Oa2927  1
2015 Spira A, Halmos B, Powell CA. Update in lung cancer 2014 American Journal of Respiratory and Critical Care Medicine. 192: 283-294. DOI: 10.1164/rccm.201504-0756UP  1
2015 Mazzilli SA, Liu G, Zhang X, Si H, Lam S, Lenburg M, Spira A, Beane JE. Abstract A11: Airway gene expression indicates an increase in oxidative phosphorylation in the field of injury of individuals with premalignant lesions Cancer Prevention Research. 8. DOI: 10.1158/1940-6215.Prev-14-A11  1
2015 Perez-Rogers JF, Gerrein J, Anderlind C, Kusko RL, Campbell JD, Wang TW, Porta K, Whitney D, Spira A, Lenburg M. Abstract A1-66: Leveraging Gene Expression in the Bronchial Airway to Develop a Nasal Biomarker for Early Detection of Lung Cancer Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-A1-66  1
2015 Tassinari A, Zhang B, Steiling K, Whitney D, Porta K, Lam S, Lenburg M, Spira A, Beane J. Abstract B1-17: Airway gene-coexpression network rewiring in the presence of bronchial dysplasia and lung cancer Cancer Research. 75. DOI: 10.1158/1538-7445.Compsysbio-B1-17  1
2015 Pavel AB, Campbell JD, Liu G, Zhang S, Liu H, Luo L, Xiao J, Porta K, Whitney D, Dubinett S, Elashoff D, Lenburg ME, Spira A. Abstract 3077: Dysregulation of microRNA-mRNA regulatory networks in the bronchial airway epithelium of smokers with lung cancer Cancer Research. 75: 3077-3077. DOI: 10.1158/1538-7445.Am2015-3077  1
2015 Beane JE, Campbell J, Moy C, Perdomo C, Schaffer M, Mazzilli S, Geshalter Y, Kantrowitz J, Zhang L, Jenkins D, Pine MB, Dhillon S, Liu G, Liu H, Zhang S, ... ... Spira A, et al. Abstract 2878: Development of the pre-cancer genome atlas (PCGA) for squamous cell lung carcinoma Cancer Research. 75: 2878-2878. DOI: 10.1158/1538-7445.Am2015-2878  1
2015 Perez-Rogers J, Gerrein J, Anderlind C, Xiao X, Liu H, Kusko R, Campbell J, Wang T, Alekseyev Y, Liu G, Porta K, Whitney D, Spira A, Lenburg M. Abstract 1574: Leveraging bronchial airway gene expression to develop a nasal biomarker for lung cancer detection Cancer Research. 75: 1574-1574. DOI: 10.1158/1538-7445.Am2015-1574  1
2015 Grayson PC, Steiling K, Platt M, Berman JS, Zhang X, Xiao J, Alekseyev YO, Liu G, Monach PA, Kaplan MJ, Spira A, Merkel PA. Brief report: Defining the nasal transcriptome in granulomatosis with polyangiitis (Wegener's) Arthritis and Rheumatology. 67: 2233-2239. DOI: 10.1002/art.39185  1
2014 Yang IV, Pedersen BS, Rabinovich E, Hennessy CE, Davidson EJ, Murphy E, Guardela BJ, Tedrow JR, Zhang Y, Singh MK, Correll M, Schwarz MI, Geraci M, Sciurba FC, Quackenbush J, ... Spira A, et al. Relationship of DNA methylation and gene expression in idiopathic pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine. 190: 1263-72. PMID 25333685 DOI: 10.1164/Rccm.201408-1452Oc  1
2014 Lamontagne M, Timens W, Hao K, Bossé Y, Laviolette M, Steiling K, Campbell JD, Couture C, Conti M, Sherwood K, Hogg JC, Brandsma CA, van den Berge M, Sandford A, Lam S, ... ... Spira A, et al. Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction. Thorax. 69: 997-1004. PMID 25182044 DOI: 10.1136/Thoraxjnl-2014-205630  1
2014 Wang X, Pittman GS, Bandele OJ, Bischof JJ, Liu G, Brothers JF, Spira A, Bell DA. Linking polymorphic p53 response elements with gene expression in airway epithelial cells of smokers and cancer risk. Human Genetics. 133: 1467-76. PMID 25179167 DOI: 10.1007/S00439-014-1483-8  1
2014 Yoo S, Huang T, Campbell JD, Lee E, Tu Z, Geraci MW, Powell CA, Schadt EE, Spira A, Zhu J. MODMatcher: multi-omics data matcher for integrative genomic analysis. Plos Computational Biology. 10: e1003790. PMID 25122495 DOI: 10.1371/Journal.Pcbi.1003790  1
2014 Kathuria H, Gesthalter Y, Spira A, Brody JS, Steiling K. Updates and controversies in the rapidly evolving field of lung cancer screening, early detection, and chemoprevention. Cancers. 6: 1157-79. PMID 24840047 DOI: 10.3390/Cancers6021157  1
2014 Ooi AT, Gower AC, Zhang KX, Vick JL, Hong L, Nagao B, Wallace WD, Elashoff DA, Walser TC, Dubinett SM, Pellegrini M, Lenburg ME, Spira A, Gomperts BN. Molecular profiling of premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis. Cancer Prevention Research (Philadelphia, Pa.). 7: 487-95. PMID 24618292 DOI: 10.1158/1940-6207.Capr-13-0372  1
2014 Christmann RB, Sampaio-Barros P, Stifano G, Borges CL, de Carvalho CR, Kairalla R, Parra ER, Spira A, Simms R, Capellozzi VL, Lafyatis R. Association of Interferon- and transforming growth factor β-regulated genes and macrophage activation with systemic sclerosis-related progressive lung fibrosis. Arthritis & Rheumatology (Hoboken, N.J.). 66: 714-25. PMID 24574232 DOI: 10.1002/Art.38288  1
2014 Kadara H, Fujimoto J, Yoo SY, Maki Y, Gower AC, Kabbout M, Garcia MM, Chow CW, Chu Z, Mendoza G, Shen L, Kalhor N, Hong WK, Moran C, Wang J, ... Spira A, et al. Transcriptomic architecture of the adjacent airway field cancerization in non-small cell lung cancer. Journal of the National Cancer Institute. 106: dju004. PMID 24563515 DOI: 10.1093/Jnci/Dju004  1
2014 Krysan K, Kusko R, Grogan T, O'Hearn J, Reckamp KL, Walser TC, Garon EB, Lenburg ME, Sharma S, Spira AE, Elashoff D, Dubinett SM. PGE2-driven expression of c-Myc and oncomiR-17-92 contributes to apoptosis resistance in NSCLC. Molecular Cancer Research : McR. 12: 765-74. PMID 24469837 DOI: 10.1158/1541-7786.Mcr-13-0377  1
2014 Vucic EA, Chari R, Thu KL, Wilson IM, Cotton AM, Kennett JY, Zhang M, Lonergan KM, Steiling K, Brown CJ, McWilliams A, Ohtani K, Lenburg ME, Sin DD, Spira A, et al. DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways. American Journal of Respiratory Cell and Molecular Biology. 50: 912-22. PMID 24298892 DOI: 10.1165/Rcmb.2013-0304Oc  1
2014 van den Berge M, Steiling K, Timens W, Hiemstra PS, Sterk PJ, Heijink IH, Liu G, Alekseyev YO, Lenburg ME, Spira A, Postma DS. Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity. Thorax. 69: 14-23. PMID 23925644 DOI: 10.1136/Thoraxjnl-2012-202878  1
2014 Jiwani A, Maple E, Schnall M, Mahon I, Apgar C, Browning R, More K, Morris M, Parrish J, Atwood C, Battaile J, Garshick E, Gatsonis C, Goldstein R, Kieth R, ... ... Spira A, et al. Detection and Validation of Molecular Biomarkers for the Early Detection of Lung Cancer Among Military and Veteran Populations: The DECAMP Consortium Chest. 146: 590A. DOI: 10.1378/Chest.1993874  0.04
2014 Park SJ, Walser TC, Perdomo C, Wang T, Hong L, Pagano PC, Liclican EL, Krysan K, Larsen JE, Fishbein MC, Minna JD, Lenburg ME, Spira A, Dubinett SM. Abstract 932: The impact of e-cigarette exposure on pulmonary epithelium gene expression and transformation Cancer Research. 74: 932-932. DOI: 10.1158/1538-7445.Am2014-932  1
2014 Kusko R, Garrison C, Wang T, Campbell J, Perez-Rogers J, Luo L, Beane J, Liu G, Kadara H, Belinsky S, Lenburg ME, Spira A. Abstract 3554: Gene and miRNA expression networks specific to never smoker lung adenocarcinoma Cancer Research. 74: 3554-3554. DOI: 10.1158/1538-7445.Am2014-3554  1
2014 Hijazi K, Bomalysz B, Steiling K, Xiao J, Liu G, Alekseyev Y, Yves MD, Hertsgaard LA, Jensen J, Vogel RI, Hatsukami D, O'Connor G, Brooks DR, Beane J, Spira A. Abstract 2354: Nasal gene expression reflects the physiologic response to potentially reduced exposure products Cancer Research. 74: 2354-2354. DOI: 10.1158/1538-7445.Am2014-2354  1
2014 Kusko R, Anderlind C, Wang G, Zhang S, Wallace WD, Wasler T, Ebright M, Garcia MM, Eisenberg R, Lee G, Liu G, Elashoff D, Kalhor N, Moran C, Mehran R, ... ... Spira A, et al. Abstract 2352: Mapping the airway-wide molecular field of injury in smokers with lung cancer Cancer Research. 74: 2352-2352. DOI: 10.1158/1538-7445.Am2014-2352  1
2014 Maki Y, Fujimoto J, Yoo S, Garcia M, Gower A, Shen L, Chow C, Behrens C, Kalhor N, Moran C, Wang J, Spira A, Coombes KR, Wistuba II, Kadara H. Abstract 1597: Transcriptomic architecture of the field of cancerization in the adjacent normal-appearing airway: Early mechanisms in lung carcinogenesis Cancer Research. 74: 1597-1597. DOI: 10.1158/1538-7445.Am2014-1597  1
2014 Pavel A, Campbell J, Liu G, Zhang S, Liu H, Dubinett S, Elashoff D, Porta K, Whitney D, Lenburg M, Spira A. Abstract 1485: Biomarker development for lung cancer diagnosis using integrative microRNA and gene expression networks Cancer Research. 74: 1485-1485. DOI: 10.1158/1538-7445.Am2014-1485  1
2014 Tassinari A, Whitney D, Porta K, Lenburg M, Spira A, Beane J. Abstract 1414: Race-associated variation in the airway transcriptome response to cigarette smoke Cancer Research. 74: 1414-1414. DOI: 10.1158/1538-7445.Am2014-1414  1
2013 Christenson SA, Brandsma CA, Campbell JD, Knight DA, Pechkovsky DV, Hogg JC, Timens W, Postma DS, Lenburg M, Spira A. miR-638 regulates gene expression networks associated with emphysematous lung destruction. Genome Medicine. 5: 114. PMID 24380442 DOI: 10.1186/Gm519  1
2013 Steiling K, Lenburg ME, Spira A. Personalized management of chronic obstructive pulmonary disease via transcriptomic profiling of the airway and lung. Annals of the American Thoracic Society. 10: S190-6. PMID 24313772 DOI: 10.1513/Annalsats.201306-190Aw  1
2013 Perdomo C, Campbell JD, Gerrein J, Tellez CS, Garrison CB, Walser TC, Drizik E, Si H, Gower AC, Vick J, Anderlind C, Jackson GR, Mankus C, Schembri F, O'Hara C, ... ... Spira A, et al. MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis. Proceedings of the National Academy of Sciences of the United States of America. 110: 18946-51. PMID 24158479 DOI: 10.1073/Pnas.1220319110  1
2013 Dubinett SM, Spira A. Challenge and opportunity of targeted lung cancer chemoprevention. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 31: 4169-71. PMID 24002497 DOI: 10.1200/Jco.2013.51.2400  1
2013 Krysan K, Cui X, Gardner BK, Reckamp KL, Wang X, Hong L, Walser TC, Rodriguez NL, Pagano PC, Garon EB, Brothers JF, Elashoff D, Lee JM, Spira AE, Sharma S, et al. Elevated neutrophil gelatinase-associated lipocalin contributes to erlotinib resistance in non-small cell lung cancer. American Journal of Translational Research. 5: 481-96. PMID 23977408  1
2013 Coleman DL, Spira A, Ravid K. Promoting interdisciplinary research in departments of medicine: results from two models at Boston University School of Medicine. Transactions of the American Clinical and Climatological Association. 124: 275-282. PMID 23874035  1
2013 Brothers JF, Hijazi K, Mascaux C, El-Zein RA, Spitz MR, Spira A. Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era. Bmc Medicine. 11: 168. PMID 23870182 DOI: 10.1186/1741-7015-11-168  1
2013 Hossein-nezhad A, Spira A, Holick MF. Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial. Plos One. 8: e58725. PMID 23527013 DOI: 10.1371/Journal.Pone.0058725  1
2013 Zhang X, Lenburg ME, Spira A. Comparison of nasal epithelial smoking-induced gene expression on Affymetrix Exon 1.0 and Gene 1.0 ST arrays. Thescientificworldjournal. 2013: 951416. PMID 23476154 DOI: 10.1155/2013/951416  1
2013 Steiling K, van den Berge M, Hijazi K, Florido R, Campbell J, Liu G, Xiao J, Zhang X, Duclos G, Drizik E, Si H, Perdomo C, Dumont C, Coxson HO, Alekseyev YO, ... ... Spira A, et al. A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment. American Journal of Respiratory and Critical Care Medicine. 187: 933-42. PMID 23471465 DOI: 10.1164/Rccm.201208-1449Oc  1
2013 Jean JC, George E, Kaestner KH, Brown LA, Spira A, Joyce-Brady M. Transcription factor Klf4, induced in the lung by oxygen at birth, regulates perinatal fibroblast and myofibroblast differentiation. Plos One. 8: e54806. PMID 23372771 DOI: 10.1371/Journal.Pone.0054806  1
2013 Gomperts BN, Walser TC, Spira A, Dubinett SM. Enriching the molecular definition of the airway "field of cancerization:" establishing new paradigms for the patient at risk for lung cancer. Cancer Prevention Research (Philadelphia, Pa.). 6: 4-7. PMID 23233734 DOI: 10.1158/1940-6207.Capr-12-0470  1
2013 Park SJ, Walser TC, Perdomo C, Pagano PP, Brass D, Liclican EL, Krysan K, Lenburg ME, Spira A, Dubinett SM. Abstract C58: The gene expression and functional impact of E-cigarette exposure on pulmonary epithelial transformation Cancer Prevention Research. 6. DOI: 10.1158/1940-6215.Prev-13-C58  1
2013 Hijazi K, Malyszko B, Steiling K, Zhang X, Liu G, Alekseyev Y, Xiao J, Dumas M, Hertsgaard L, Jenson J, Rohde C, Isaksson R, Hatsukami D, Hecht S, Brooks D, ... ... Spira A, et al. Abstract 4030: Nasal gene expression reflects the physiologic response to alternate tobacco products. Cancer Research. 73: 4030-4030. DOI: 10.1158/1538-7445.Am2013-4030  1
2013 Maki Y, Fujimoto J, Yoo S, Gower A, Shen L, Garcia MM, Kabbout M, Chow C, Hong WK, Kalhor N, Wang J, Moran C, Spira A, Coombes KR, Wistuba II, et al. Abstract 2367: Transcriptomic architecture of the airway field cancerization in early-stage non-small cell lung cancer . Cancer Research. 73: 2367-2367. DOI: 10.1158/1538-7445.Am2013-2367  1
2013 Wang T, Campbell J, Kusko R, Luo L, Tellez C, Liu G, Xiao J, Lenburg M, Belinsky S, Spira A. Abstract 1948: Shared and distinct microRNA-expression alterations in lung adenocarcinoma from smokers vs. nonsmokers. Cancer Research. 73: 1948-1948. DOI: 10.1158/1538-7445.Am2013-1948  1
2013 Wang TW, Lan Q, Krystyna B, Rothman N, Florido R, Hu W, Steiling K, Liu G, Xiao J, Alekseyev Y, Xu J, Wei F, Hosgood HD, Reiss B, Downward G, ... ... Spira A, et al. Abstract 112: Transcriptomic changes in the oral mucosal epithelium reflect the physiologic response to indoor burning of solid fuels. Cancer Research. 73: 112-112. DOI: 10.1158/1538-7445.Am2013-112  1
2013 Ooi AT, Gower A, Zhang K, Vick J, Hong L, Fishbein M, Nagao B, Wallace WD, Elashoff D, Lenburg M, Dubinett S, Spira A, Gomperts B. Abstract 1063: Examining early events in carcinogenesis by profiling premalignant lesions in the airways of patients with lung squamous cell carcinomas. Cancer Research. 73: 1063-1063. DOI: 10.1158/1538-7445.Am2013-1063  1
2012 Sommer CA, Christodoulou C, Gianotti-Sommer A, Shen SS, Sailaja BS, Hezroni H, Spira A, Meshorer E, Kotton DN, Mostoslavsky G. Residual expression of reprogramming factors affects the transcriptional program and epigenetic signatures of induced pluripotent stem cells. Plos One. 7: e51711. PMID 23272148 DOI: 10.1371/Journal.Pone.0051711  1
2012 Spira A, Nana-Sinkam SP. Using microRNAs to inform clinical decision making in lung cancer: ready for prime time? American Journal of Respiratory and Critical Care Medicine. 186: 1077-9. PMID 23204375 DOI: 10.1164/Rccm.201210-1757Ed  1
2012 Beane J, Cheng L, Soldi R, Zhang X, Liu G, Anderlind C, Lenburg ME, Spira A, Bild AH. SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue. Cancer Research. 72: 5702-11. PMID 22986747 DOI: 10.1158/0008-5472.Can-12-1043  1
2012 Campbell JD, McDonough JE, Zeskind JE, Hackett TL, Pechkovsky DV, Brandsma CA, Suzuki M, Gosselink JV, Liu G, Alekseyev YO, Xiao J, Zhang X, Hayashi S, Cooper JD, Timens W, ... ... Spira A, et al. A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK. Genome Medicine. 4: 67. PMID 22937864 DOI: 10.1186/Gm367  1
2012 Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, Hilliard KL, Zhang X, Sabharwal V, Algül H, Akira S, Schmid RM, Pelton SI, Spira A, Mizgerd JP. Hepatocyte-specific mutation of both NF-κB RelA and STAT3 abrogates the acute phase response in mice. The Journal of Clinical Investigation. 122: 1758-63. PMID 22466650 DOI: 10.1172/Jci59408  1
2012 Tagne JB, Gupta S, Gower AC, Shen SS, Varma S, Lakshminarayanan M, Cao Y, Spira A, Volkert TL, Ramirez MI. Genome-wide analyses of Nkx2-1 binding to transcriptional target genes uncover novel regulatory patterns conserved in lung development and tumors. Plos One. 7: e29907. PMID 22242187 DOI: 10.1371/Journal.Pone.0029907  1
2012 Whitney D, Luo J, Porta K, Lenburg M, Brody J, Ernst A, Vachani A, Ferguson J, Silvestri G, Spira A. Bronchial Airway Gene-Expression Testing Improves the Diagnostic Yield of Bronchoscopy for Lung Cancer: Results of the AEGIS Trial Chest. 142: 1025A. DOI: 10.1378/Chest.1450411  0.01
2012 Campbell JD, Luo L, Liu G, Xiao J, Gerrein J, Guardela BJ, Tedrow J, Aleksyev YO, Yang IV, Correll M, Geraci M, Quackenbush J, Sciurba F, Schwartz DA, Kaminski N, ... ... Spira A, et al. Characterizing the small RNA transcriptome associated with COPD and ILD using next-generation sequencing Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S6-P6  0.08
2012 Brothers J, Kusko R, Liu G, Luo L, Guardela BJ, Tedrow J, Alekesyev Y, Yang IV, Correll M, Geraci M, Quackenbush J, Sciurba F, Sebastiani P, Lenburg M, Kaminski N, ... ... Spira A, et al. Moving beyond gene expression: identification of lung-disease-associated novel transcripts and alternative splicing by RNA sequencing Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S6-P4  0.04
2012 Wang TW, Campbell JD, Luo L, Liu G, Xiao J, Lenburg ME, Belinsky SA, Spira A. Deep sequencing of the microRNA transcriptome in current, former, and never smokers with lung adenocarcinoma Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S6-P38  0.01
2012 Kusko RL, Brothers J, Liu G, Luo L, Guardela BJ, Tedrow J, Aleksyev Y, Yang IV, Correll M, Geraci M, Quackenbush J, Sciurba F, Lenburg M, Schwartz DA, Beane J, ... ... Spira A, et al. Comprehensive genomic profiling of the lung transcriptome in emphysema and idiopathic pulmonary fibrosis using RNA-Seq Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S6-P21  0.01
2012 Belinsky SA, Spira A, Tellez C. Abstract CN06-02: Epigenetic Deregulation of MicroRNAs During Tobacco Carcinogen-Induced Transformation of Bronchial Epithelial Cells Cancer Prevention Research. 5: CN06-02-CN06-02. DOI: 10.1158/1940-6207.PREV-12-CN06-02  0.01
2012 Hijazi K, Malyszko B, Zhang X, Liu G, Alekseyev Y, Dumas Y, Hertsgaard L, Jenson J, Rohde C, Hatsukami DK, Hecht SS, Brooks DR, O'Connor G, Lenburg M, Steiling K, ... Spira A, et al. Abstract B07: Nasal epithelial gene expression profiles reflect dynamic biological response to smoking cessation Cancer Prevention Research. 5: B07-B07. DOI: 10.1158/1940-6207.Prev-12-B07  0.01
2012 Perdomo C, Campbell J, Gerrein J, Tellez C, Gower A, Vick J, Garrison C, Anderlind C, Jackson GR, Schembri F, Gomperts BN, Hayden P, Belinsky SA, Lenburg ME, Spira A. Abstract 3173: Identification of miR-4423 as a primate-specific microRNA highly expressed in airway epithelium and associated with lung cancer Cancer Research. 72: 3173-3173. DOI: 10.1158/1538-7445.Am2012-3173  1
2012 Campbell JD, Luo L, Xiao J, Liu G, Aleksyev Y, Elashoff D, Dubinett SM, Lenburg ME, Spira A. Abstract 3154: Sequencing of the small RNA transcriptome in cytologically normal bronchial airway epithelium of smokers with and without lung cancer Cancer Research. 72: 3154-3154. DOI: 10.1158/1538-7445.Am2012-3154  1
2012 Beane JE, Hijazi K, Liu G, Zhang X, Xiao J, Lam S, Lenburg M, Spira A. Abstract 1607: Airway gene expression alterations associated with lung cancer chemoprevention using green tea extract Cancer Research. 72: 1607-1607. DOI: 10.1158/1538-7445.Am2012-1607  1
2011 Gower AC, Spira A, Lenburg ME. Discovering biological connections between experimental conditions based on common patterns of differential gene expression. Bmc Bioinformatics. 12: 381. PMID 21951600 DOI: 10.1186/1471-2105-12-381  1
2011 Cohen AL, Soldi R, Zhang H, Gustafson AM, Wilcox R, Welm BE, Chang JT, Johnson E, Spira A, Jeffrey SS, Bild AH. A pharmacogenomic method for individualized prediction of drug sensitivity. Molecular Systems Biology. 7: 513. PMID 21772261 DOI: 10.1038/Msb.2011.47  1
2011 Beane J, Vick J, Schembri F, Anderlind C, Gower A, Campbell J, Luo L, Zhang XH, Xiao J, Alekseyev YO, Wang S, Levy S, Massion PP, Lenburg M, Spira A. Characterizing the impact of smoking and lung cancer on the airway transcriptome using RNA-Seq. Cancer Prevention Research (Philadelphia, Pa.). 4: 803-17. PMID 21636547 DOI: 10.1158/1940-6207.Capr-11-0212  1
2011 Perdomo C, Spira A, Schembri F. MiRNAs as regulators of the response to inhaled environmental toxins and airway carcinogenesis. Mutation Research. 717: 32-7. PMID 21549133 DOI: 10.1016/J.Mrfmmm.2011.04.005  1
2011 Gower AC, Steiling K, Brothers JF, Lenburg ME, Spira A. Transcriptomic studies of the airway field of injury associated with smoking-related lung disease. Proceedings of the American Thoracic Society. 8: 173-9. PMID 21543797 DOI: 10.1513/pats.201011-066MS  1
2011 Christodoulou C, Longmire TA, Shen SS, Bourdon A, Sommer CA, Gadue P, Spira A, Gouon-Evans V, Murphy GJ, Mostoslavsky G, Kotton DN. Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes. The Journal of Clinical Investigation. 121: 2313-25. PMID 21537085 DOI: 10.1172/Jci43853  1
2011 Gomperts BN, Spira A, Massion PP, Walser TC, Wistuba II, Minna JD, Dubinett SM. Evolving concepts in lung carcinogenesis. Seminars in Respiratory and Critical Care Medicine. 32: 32-43. PMID 21500122 DOI: 10.1055/S-0031-1272867  1
2011 Campbell JD, Spira A, Lenburg ME. Applying gene expression microarrays to pulmonary disease. Respirology (Carlton, Vic.). 16: 407-18. PMID 21299687 DOI: 10.1111/J.1440-1843.2011.01942.X  1
2011 Boelens MC, Gustafson AM, Postma DS, Kok K, van der Vries G, van der Vlies P, Spira A, Lenburg ME, Geerlings M, Sietsma H, Timens W, van den Berg A, Groen HJ. A chronic obstructive pulmonary disease related signature in squamous cell lung cancer. Lung Cancer (Amsterdam, Netherlands). 72: 177-83. PMID 20832896 DOI: 10.1016/J.Lungcan.2010.08.014  1
2011 Gerrein J, Perdomo C, Campbell JD, Vick J, Gower A, Anderlind C, Schembri F, Lenburg M, Spira A. Abstract 3989: Discovery of a novel airway microRNA associated with lung cancer using next generation sequencing Cellular and Molecular Biology. 71: 3989-3989. DOI: 10.1158/1538-7445.Am2011-3989  1
2010 Ooi AT, Mah V, Nickerson DW, Gilbert JL, Ha VL, Hegab AE, Horvath S, Alavi M, Maresh EL, Chia D, Gower AC, Lenburg ME, Spira A, Solis LM, Wistuba II, et al. Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer. Cancer Research. 70: 6639-48. PMID 20710044 DOI: 10.1158/0008-5472.Can-10-0455  1
2010 Wang X, Chorley BN, Pittman GS, Kleeberger SR, Brothers J, Liu G, Spira A, Bell DA. Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. Plos One. 5: e11934. PMID 20689807 DOI: 10.1371/Journal.Pone.0011934  1
2010 Wu J, Qian J, Li C, Kwok L, Cheng F, Liu P, Perdomo C, Kotton D, Vaziri C, Anderlind C, Spira A, Cardoso WV, Lü J. miR-129 regulates cell proliferation by downregulating Cdk6 expression. Cell Cycle (Georgetown, Tex.). 9: 1809-18. PMID 20404570 DOI: 10.4161/Cc.9.9.11535  1
2010 Gustafson AM, Soldi R, Anderlind C, Scholand MB, Qian J, Zhang X, Cooper K, Walker D, McWilliams A, Liu G, Szabo E, Brody J, Massion PP, Lenburg ME, Lam S, ... ... Spira A, et al. Airway PI3K pathway activation is an early and reversible event in lung cancer development. Science Translational Medicine. 2: 26ra25. PMID 20375364 DOI: 10.1126/Scitranslmed.3000251  1
2010 Gomperts BN, Spira A, Elashoff DE, Dubinett SM. Lung cancer biomarkers: FISHing in the sputum for risk assessment and early detection. Cancer Prevention Research (Philadelphia, Pa.). 3: 420-3. PMID 20332300 DOI: 10.1158/1940-6207.Capr-10-0052  1
2010 Spira A. Upper airway gene expression in smokers: the mouth as a "window to the soul" of lung carcinogenesis? Cancer Prevention Research (Philadelphia, Pa.). 3: 255-8. PMID 20179303 DOI: 10.1158/1940-6207.Capr-10-0013  1
2010 Zhang X, Sebastiani P, Liu G, Schembri F, Zhang X, Dumas YM, Langer EM, Alekseyev Y, O'Connor GT, Brooks DR, Lenburg ME, Spira A. Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium. Physiological Genomics. 41: 1-8. PMID 19952278 DOI: 10.1152/Physiolgenomics.00167.2009  1
2010 Hazra S, Gardner BK, Krysan K, Walser TC, Larsen JE, Pertsemlidis A, Shay JW, Minna JD, Spira A, Dubinett SM. Abstract A31: The role of microRNA 125a‐3P in the pathogenesis of lung cancer Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-09-A31  1
2010 Ooi AT, Mah VH, Nickerson DW, Gilbert JL, Ha VL, Hegab AE, Horvath S, Alavi M, Maresh E, Chia D, Gower AC, Lenburg ME, Spira A, Walser T, Wallace WD, et al. Abstract 4299: Poor prognosis in smokers with non-small cell lung cancer correlates with the presence of a reparative progenitor cell population Cancer Research. 70: 4299-4299. DOI: 10.1158/1538-7445.Am10-4299  1
2010 Beane J, Gerrein J, Vick J, Gindin Y, Anderlind C, Levy S, Massion P, Schembri F, Lenburg M, Spira A. Abstract 1987: RNA-seq of the bronchial airway transcriptome identifies novel gene and microRNA expression changes associated with smoking and lung cancer Cancer Research. 70: 1987-1987. DOI: 10.1158/1538-7445.Am10-1987  1
2009 Steiling K, Lenburg ME, Spira A. Airway gene expression in chronic obstructive pulmonary disease. Proceedings of the American Thoracic Society. 6: 697-700. PMID 20008878 DOI: 10.1513/pats.200907-076DP  1
2009 Silverman EK, Spira A, Paré PD. Genetics and genomics of chronic obstructive pulmonary disease. Proceedings of the American Thoracic Society. 6: 539-42. PMID 19741265 DOI: 10.1513/pats.200904-021DS  1
2009 Steiling K, Kadar AY, Bergerat A, Flanigon J, Sridhar S, Shah V, Ahmad QR, Brody JS, Lenburg ME, Steffen M, Spira A. Comparison of proteomic and transcriptomic profiles in the bronchial airway epithelium of current and never smokers. Plos One. 4: e5043. PMID 19357784 DOI: 10.1371/Journal.Pone.0005043  1
2009 Schembri F, Sridhar S, Perdomo C, Gustafson AM, Zhang X, Ergun A, Lu J, Liu G, Zhang X, Bowers J, Vaziri C, Ott K, Sensinger K, Collins JJ, Brody JS, ... ... Spira A, et al. MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proceedings of the National Academy of Sciences of the United States of America. 106: 2319-24. PMID 19168627 DOI: 10.1073/Pnas.0806383106  1
2009 Beane J, Spira A, Lenburg ME. Clinical impact of high-throughput gene expression studies in lung cancer. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 4: 109-18. PMID 19096318 DOI: 10.1097/Jto.0B013E31819151F8  1
2009 Bild A, Sun Y, Soldi R, Conner T, Walker D, Werner T, Spira A, Andrulis I, Buys S, Johnson E. A Genomic Biomarker for Breast Cancer Development in High-Risk Women. Cancer Research. 69: 4059-4059. DOI: 10.1158/0008-5472.Sabcs-09-4059  1
2009 Soldi R, Gustafson A, Zhu H, Wilcox R, Welm B, Spira A, Jeffrey S, Bild A. A Phenotype-Based Model for Rational Selection of Novel Targeted Therapies in Treating Aggressive Breast Cancer. Cancer Research. 69: 2007-2007. DOI: 10.1158/0008-5472.Sabcs-09-2007  1
2009 Kathuria H, Spira A, Brody J. Genomics of Lung Cancer Genomic and Personalized Medicine, Two-Vol Set. 856-868. DOI: 10.1016/B978-0-12-369420-1.00071-8  1
2008 Steiling K, Ryan J, Brody JS, Spira A. The field of tissue injury in the lung and airway. Cancer Prevention Research (Philadelphia, Pa.). 1: 396-403. PMID 19138985 DOI: 10.1158/1940-6207.Capr-08-0174  1
2008 Beane J, Sebastiani P, Whitfield TH, Steiling K, Dumas YM, Lenburg ME, Spira A. A prediction model for lung cancer diagnosis that integrates genomic and clinical features. Cancer Prevention Research (Philadelphia, Pa.). 1: 56-64. PMID 19138936 DOI: 10.1158/1940-6207.Capr-08-0011  1
2008 Zeskind JE, Lenburg ME, Spira A. Translating the COPD transcriptome: insights into pathogenesis and tools for clinical management. Proceedings of the American Thoracic Society. 5: 834-41. PMID 19017738 DOI: 10.1513/pats.200807-074TH  1
2008 Sridhar S, Schembri F, Zeskind J, Shah V, Gustafson AM, Steiling K, Liu G, Dumas YM, Zhang X, Brody JS, Lenburg ME, Spira A. Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium. Bmc Genomics. 9: 259. PMID 18513428 DOI: 10.1186/1471-2164-9-259  1
2008 Millien G, Beane J, Lenburg M, Tsao PN, Lu J, Spira A, Ramirez MI. Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction. Gene Expression Patterns : Gep. 8: 124-39. PMID 18023262 DOI: 10.1016/J.Modgep.2007.09.003  1
2008 Gitin Y, Farraye FA, Zhang X, Liu G, Spira A, Brody JS. M2066 Evaluation of Global Gene Expression in Rectal Mucosa Obtained By a Non-Invasive Technique in Patients with Ulcerative Colitis Gastroenterology. 134: A-462. DOI: 10.1016/S0016-5085(08)62159-9  0.04
2007 Zhang X, Liu G, Lenburg ME, Spira A. Comparison of smoking-induced gene expression on Affymetrix Exon and 3'-based expression arrays. Genome Informatics. International Conference On Genome Informatics. 18: 247-57. PMID 18546492 DOI: 10.11234/Gi1990.18.247  1
2007 Beane J, Sebastiani P, Liu G, Brody JS, Lenburg ME, Spira A. Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression. Genome Biology. 8: R201. PMID 17894889 DOI: 10.1186/Gb-2007-8-9-R201  1
2007 Spira A, Beane JE, Shah V, Steiling K, Liu G, Schembri F, Gilman S, Dumas YM, Calner P, Sebastiani P, Sridhar S, Beamis J, Lamb C, Anderson T, Gerry N, et al. Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer. Nature Medicine. 13: 361-6. PMID 17334370 DOI: 10.1038/Nm1556  1
2006 Brody JS, Spira A. State of the art. Chronic obstructive pulmonary disease, inflammation, and lung cancer. Proceedings of the American Thoracic Society. 3: 535-7. PMID 16921139 DOI: 10.1513/pats.200603-089MS  1
2006 DeMeo D, Mariani T, Lange C, Lake S, Litonjua A, Celedón J, Reilly J, Chapman HA, Sparrow D, Spira A, Beane J, Pinto-Plata V, Speizer FE, Shapiro S, Weiss ST, et al. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Proceedings of the American Thoracic Society. 3: 502. PMID 16921128 DOI: 10.1513/pats.200603-070MS  1
2006 Millien G, Spira A, Hinds A, Wang J, Williams MC, Ramirez MI. Alterations in gene expression in T1 alpha null lung: a model of deficient alveolar sac development. Bmc Developmental Biology. 6: 35. PMID 16869965 DOI: 10.1186/1471-213X-6-35  1
2006 Demeo DL, Mariani TJ, Lange C, Srisuma S, Litonjua AA, Celedon JC, Lake SL, Reilly JJ, Chapman HA, Mecham BH, Haley KJ, Sylvia JS, Sparrow D, Spira AE, Beane J, et al. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. American Journal of Human Genetics. 78: 253-64. PMID 16358219 DOI: 10.1086/499828  1
2005 Shah V, Sridhar S, Beane J, Brody JS, Spira A. SIEGE: Smoking Induced Epithelial Gene Expression Database. Nucleic Acids Research. 33: D573-9. PMID 15608264 DOI: 10.1093/Nar/Gki035  1
2004 Spira A, Beane J, Pinto-Plata V, Kadar A, Liu G, Shah V, Celli B, Brody JS. Gene expression profiling of human lung tissue from smokers with severe emphysema. American Journal of Respiratory Cell and Molecular Biology. 31: 601-10. PMID 15374838 DOI: 10.1165/Rcmb.2004-0273Oc  1
2004 Spira A, Beane J, Shah V, Liu G, Schembri F, Yang X, Palma J, Brody JS. Effects of cigarette smoke on the human airway epithelial cell transcriptome. Proceedings of the National Academy of Sciences of the United States of America. 101: 10143-8. PMID 15210990 DOI: 10.1073/Pnas.0401422101  1
2004 Spira A, Schembri F, Beane J, Shah V, Liu G, Brody JS. Impact of cigarette smoke on the normal airway transcriptome. Chest. 125: 115S. PMID 15136455 DOI: 10.1378/Chest.125.5_Suppl.115S  1
2004 Spira A, Beane J, Schembri F, Liu G, Ding C, Gilman S, Yang X, Cantor C, Brody JS. Noninvasive method for obtaining RNA from buccal mucosa epithelial cells for gene expression profiling. Biotechniques. 36: 484-7. PMID 15038164 DOI: 10.2144/04363Rn03  1
2003 Spira A, Carroll JD, Liu G, Aziz Z, Shah V, Kornfeld H, Keane J. Apoptosis genes in human alveolar macrophages infected with virulent or attenuated Mycobacterium tuberculosis: a pivotal role for tumor necrosis factor. American Journal of Respiratory Cell and Molecular Biology. 29: 545-51. PMID 12748057 DOI: 10.1165/Rcmb.2002-0310Oc  1
2003 Powell CA, Spira A, Derti A, DeLisi C, Liu G, Borczuk A, Busch S, Sahasrabudhe S, Chen Y, Sugarbaker D, Bueno R, Richards WG, Brody JS. Gene expression in lung adenocarcinomas of smokers and nonsmokers. American Journal of Respiratory Cell and Molecular Biology. 29: 157-62. PMID 12600827 DOI: 10.1165/Rcmb.2002-0183Rc  1
2002 Spira A, Brecher S, Karlinsky J. Pulmonary mucormycosis in the setting of chronic obstructive pulmonary disease. A case report and review of the literature. Respiration; International Review of Thoracic Diseases. 69: 560-3. PMID 12457013 DOI: 10.1159/000066467  0.01
2002 Kremer H-, Kadota J, Kohno S, Hasegawa Y, Imaizumi K, Sekido Y, Iinuma Y, Kawabe T, Hashimoto N, Shimokata K, Tønnesen P, Burgaud J, Bolliger CT, Gückel C, Engel H, ... ... Spira A, et al. Contents Vol. 69, 2002 Respiration. 69: 579-583. DOI: 10.1159/000068065  0.01
2002 Kremer H-, Kadota J, Kohno S, Hasegawa Y, Imaizumi K, Sekido Y, Iinuma Y, Kawabe T, Hashimoto N, Shimokata K, Tønnesen P, Burgaud J, Bolliger CT, Gückel C, Engel H, ... ... Spira A, et al. Subject Index Vol. 69, 2002 Respiration. 69: 577-578. DOI: 10.1159/000068064  0.01
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