Antonio DiGiandomenico, Ph.D. - Publications

Affiliations: 
2006 University of Virginia, Charlottesville, VA 
Area:
Microbiology Biology, Immunology

37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Moustafa DA, DiGiandomenico A, Raghuram V, Schulman M, Scarff JM, Davis MR, Varga JJ, Dean CR, Goldberg JB. Efficacy of a serogroup O9 vaccine. Infection and Immunity. e0024723. PMID 37991349 DOI: 10.1128/iai.00247-23  0.783
2023 Moustafa DA, DiGiandomenico A, Raghuram V, Schulman M, Scarff JM, Davis MR, Varga JJ, Dean CR, Goldberg JB. Efficacy of a Serogroup O9 Vaccine. Biorxiv : the Preprint Server For Biology. PMID 37502855 DOI: 10.1101/2023.07.13.548830  0.783
2022 Shaikh MOF, Schaefers MM, Merakou C, DiBlasi M, Bonney S, Liao T, Zurakowski D, Kehl M, Tabor DE, DiGiandomenico A, Priebe GP. Multicomponent Pseudomonas aeruginosa Vaccines Eliciting Th17 Cells and Functional Antibody Responses Confer Enhanced Protection against Experimental Acute Pneumonia in Mice. Infection and Immunity. e0020322. PMID 36069593 DOI: 10.1128/iai.00203-22  0.308
2019 Kugadas A, Geddes-McAlister J, Guy E, DiGiandomenico A, Sykes DB, Mansour MK, Mirchev R, Gadjeva M. Frontline Science: Employing enzymatic treatment options for management of ocular biofilm-based infections. Journal of Leukocyte Biology. PMID 30690787 DOI: 10.1002/Jlb.4Hi0918-364Rr  0.338
2018 Chen B, Vousden KA, Naiman B, Turman S, Sun H, Wang S, Vinall LMK, Kemp BP, Kasturiangan S, Rees DG, Grant E, Hinrichs MJ, Eck S, DiGiandomenico A, Jack Borrok M, et al. Humanised effector-null FcγRIIA antibody inhibits immune complex-mediated proinflammatory responses. Annals of the Rheumatic Diseases. PMID 30459279 DOI: 10.1136/Annrheumdis-2018-213523  0.318
2018 Thompson JM, Miller RJ, Ashbaugh AG, Dillen CA, Pickett JE, Wang Y, Ortines RV, Sterling RS, Francis KP, Bernthal NM, Cohen TS, Tkaczyk C, Yu L, Stover CK, DiGiandomenico A, et al. Mouse model of Gram-negative prosthetic joint infection reveals therapeutic targets. Jci Insight. 3. PMID 30185667 DOI: 10.1172/Jci.Insight.121737  0.322
2018 Jones-Nelson O, Hilliard JJ, DiGiandomenico A, Warrener P, Alfaro A, Cheng L, Stover CK, Cohen TS, Sellman BR. The Neutrophilic Response to Pseudomonas Damages the Airway Barrier Promoting Infection by K. pneumoniae. American Journal of Respiratory Cell and Molecular Biology. PMID 30109945 DOI: 10.1165/Rcmb.2018-0107Oc  0.334
2018 Ali SO, Yu XQ, Robbie GJ, Wu Y, Shoemaker K, Yu L, DiGiandomenico A, Keller AE, Anude C, Hernandez-Illas M, Bellamy T, Falloon J, Dubovsky F, Jafri HS. A Phase 1 Study of MEDI3902, an Investigational Anti-Pseudomonas aeruginosa PcrV and Psl Bispecific Human Monoclonal Antibody, in Healthy Adults. Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases. PMID 30107283 DOI: 10.1016/J.Cmi.2018.08.004  0.311
2018 Tabor DE, Oganesyan V, Keller AE, Yu L, McLaughlin RE, Song E, Warrener P, Rosenthal K, Esser M, Qi Y, Ruzin A, Stover CK, DiGiandomenico A. Pseudomonas aeruginosa PcrV and Psl, the molecular targets of bispecific antibody MEDI3902, are conserved among diverse global clinical isolates. The Journal of Infectious Diseases. PMID 30016475 DOI: 10.1093/Infdis/Jiy438  0.352
2018 Borrok MJ, DiGiandomenico A, Beyaz N, Marchetti GM, Barnes AS, Lekstrom KJ, Phipps SS, McCarthy MP, Wu H, Dall'Acqua WF, Tsui P, Gupta R. Enhancing IgG distribution to lung mucosal tissue improves protective effect of anti-Pseudomonas aeruginosa antibodies. Jci Insight. 3. PMID 29925682 DOI: 10.1172/Jci.Insight.97844  0.324
2018 Le HN, Quetz JS, Tran VG, Le VTM, Aguiar-Alves F, Pinheiro MG, Cheng L, Yu L, Sellman BR, Stover CK, DiGiandomenico A, Diep BA. MEDI3902 correlates of protection against severepneumonia in a rabbit acute pneumonia model. Antimicrobial Agents and Chemotherapy. PMID 29483116 DOI: 10.1128/Aac.02565-17  0.333
2017 Pennini ME, De Marco A, Pelletier M, Bonnell J, Cvitkovic R, Beltramello M, Cameroni E, Bianchi S, Zatta F, Zhao W, Xiao X, Camara MM, DiGiandomenico A, Semenova E, Lanzavecchia A, et al. Immune stealth-driven O2 serotype prevalence and potential for therapeutic antibodies against multidrug resistant Klebsiella pneumoniae. Nature Communications. 8: 1991. PMID 29222409 DOI: 10.1038/S41467-017-02223-7  0.451
2017 Ray VA, Hill PJ, Stover KC, Roy S, Sen CK, Yu L, Wozniak DJ, DiGiandomenico A. Anti-Psl Targeting of Pseudomonas aeruginosa Biofilms for Neutrophil-Mediated Disruption. Scientific Reports. 7: 16065. PMID 29167572 DOI: 10.1038/S41598-017-16215-6  0.334
2017 Patel A, DiGiandomenico A, Keller AE, Smith TRF, Park DH, Ramos S, Schultheis K, Elliott STC, Mendoza J, Broderick KE, Wise MC, Yan J, Jiang J, Flingai S, Khan AS, et al. An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model. Nature Communications. 8: 637. PMID 28935938 DOI: 10.1038/S41467-017-00576-7  0.355
2017 Thanabalasuriar A, Surewaard BGJ, Willson ME, Neupane AS, Stover CK, Warrener P, Wilson G, Keller AE, Sellman BR, DiGiandomenico A, Kubes P. Bispecific antibody targets multiple Pseudomonas aeruginosa evasion mechanisms in the lung vasculature. The Journal of Clinical Investigation. PMID 28463232 DOI: 10.1172/Jci89652  0.356
2017 Chen B, Vousden K, Turman S, Sun H, Wang S, Vinall L, Kemp B, Kasturiangan S, Grant E, Hinrichs M, Eck S, DiGiandomenico A, Xiong X, Griffiths J, Herbst R, et al. OP0331 A novel humanized effector-deficient fcyriia antibody inhibits immune complex mediated proinflammatory responses Annals of the Rheumatic Diseases. 76: 192-192. DOI: 10.1136/Annrheumdis-2017-Eular.1994  0.338
2016 Cohen TS, Hilliard JJ, Jones-Nelson O, Keller AE, O'Day T, Tkaczyk C, DiGiandomenico A, Hamilton M, Pelletier M, Wang Q, Diep BA, Le VT, Cheng L, Suzich J, Stover CK, et al. Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections. Science Translational Medicine. 8: 329ra31. PMID 26962155 DOI: 10.1126/Scitranslmed.Aad9922  0.332
2016 Zegans ME, DiGiandomenico A, Ray K, Naimie A, Keller AE, Stover CK, Lalitha P, Srinivasan M, Acharya NR, Lietman TM. Association of Biofilm Formation, Psl Exopolysaccharide Expression, and Clinical Outcomes in Pseudomonas aeruginosa Keratitis: Analysis of Isolates in the Steroids for Corneal Ulcers Trial. Jama Ophthalmology. PMID 26846404 DOI: 10.1001/Jamaophthalmol.2015.5956  0.318
2015 Thaden JT, Keller AE, Shire NJ, Camara MM, Otterson L, Huband M, Guenther CM, Zhao W, Warrener P, Stover KC, Fowler VG, DiGiandomenico A. Pseudomonas aeruginosa Bacteremic Patients Exhibit Non-Protective Antibody Titers against Therapeutic Antibody Targets PcrV and Psl Exopolysaccharide. The Journal of Infectious Diseases. PMID 26333940 DOI: 10.1093/Infdis/Jiv436  0.358
2015 Moustafa DA, Scarff JM, Garcia PP, Cassidy SK, DiGiandomenico A, Waag DM, Inzana TJ, Goldberg JB. Recombinant Salmonella Expressing Burkholderia mallei LPS O Antigen Provides Protection in a Murine Model of Melioidosis and Glanders. Plos One. 10: e0132032. PMID 26148026 DOI: 10.1371/Journal.Pone.0132032  0.786
2015 Moustafa DA, Scarff JM, Garcia PP, Cassidy SKB, DiGiandomenico A, Waag DM, Inzana TJ, Goldberg JB. Opsonophagocytosis killing of B. thailandensis. Plos One. DOI: 10.1371/Journal.Pone.0132032.G006  0.716
2015 Moustafa DA, Scarff JM, Garcia PP, Cassidy SKB, DiGiandomenico A, Waag DM, Inzana TJ, Goldberg JB. Survival rates and bacterial loads in organs of intranasally immunized BALB/c mice after intranasal challenge with B . thailandensis (5 x 10 6 CFU). Plos One. DOI: 10.1371/Journal.Pone.0132032.G004  0.733
2015 Moustafa DA, Scarff JM, Garcia PP, Cassidy SKB, DiGiandomenico A, Waag DM, Inzana TJ, Goldberg JB. Serum antibody response of BALB/c mice following intranasal immunization with S . enterica serovar Typhimurium SL3261 expressing B . mallei O antigen. Plos One. DOI: 10.1371/Journal.Pone.0132032.G002  0.773
2015 Moustafa DA, Scarff JM, Garcia PP, Cassidy SKB, DiGiandomenico A, Waag DM, Inzana TJ, Goldberg JB. Analysis of LPS expression and immunoreactivity. Plos One. DOI: 10.1371/Journal.Pone.0132032.G001  0.716
2014 DiGiandomenico A, Keller AE, Gao C, Rainey GJ, Warrener P, Camara MM, Bonnell J, Fleming R, Bezabeh B, Dimasi N, Sellman BR, Hilliard J, Guenther CM, Datta V, Zhao W, et al. A multifunctional bispecific antibody protects against Pseudomonas aeruginosa. Science Translational Medicine. 6: 262ra155. PMID 25391481 DOI: 10.1126/Scitranslmed.3009655  0.366
2014 DiGiandomenico A, Veach RA, Zienkiewicz J, Moore DJ, Wylezinski LS, Hutchens MA, Hawiger J. The "genomic storm" induced by bacterial endotoxin is calmed by a nuclear transport modifier that attenuates localized and systemic inflammation. Plos One. 9: e110183. PMID 25329889 DOI: 10.1371/Journal.Pone.0110183  0.316
2014 Warrener P, Varkey R, Bonnell JC, DiGiandomenico A, Camara M, Cook K, Peng L, Zha J, Chowdury P, Sellman B, Stover CK. A novel anti-PcrV antibody providing enhanced protection against Pseudomonas aeruginosa in multiple animal infection models. Antimicrobial Agents and Chemotherapy. 58: 4384-91. PMID 24841258 DOI: 10.1128/Aac.02643-14  0.361
2013 Li H, Mo KF, Wang Q, Stover CK, DiGiandomenico A, Boons GJ. Epitope mapping of monoclonal antibodies using synthetic oligosaccharides uncovers novel aspects of immune recognition of the Psl exopolysaccharide of Pseudomonas aeruginosa. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 17425-31. PMID 24248772 DOI: 10.1002/Chem.201302916  0.353
2012 DiGiandomenico A, Warrener P, Hamilton M, Guillard S, Ravn P, Minter R, Camara MM, Venkatraman V, Macgill RS, Lin J, Wang Q, Keller AE, Bonnell JC, Tomich M, Jermutus L, et al. Identification of broadly protective human antibodies to Pseudomonas aeruginosa exopolysaccharide Psl by phenotypic screening. The Journal of Experimental Medicine. 209: 1273-87. PMID 22734046 DOI: 10.1084/Jem.20120033  0.355
2011 Rao J, Damron FH, Basler M, Digiandomenico A, Sherman NE, Fox JW, Mekalanos JJ, Goldberg JB. Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient. Frontiers in Microbiology. 2: 162. PMID 21863142 DOI: 10.3389/Fmicb.2011.00162  0.544
2011 Rao J, DiGiandomenico A, Artamonov M, Leitinger N, Amin AR, Goldberg JB. Host derived inflammatory phospholipids regulate rahU (PA0122) gene, protein, and biofilm formation in Pseudomonas aeruginosa. Cellular Immunology. 270: 95-102. PMID 21679933 DOI: 10.1016/J.Cellimm.2011.04.011  0.547
2011 Rao J, Damron FH, Basler M, DiGiandomenico A, Sherman NE, Fox JW, Mekalanos JJ, Goldberg JB. Comparisons of two proteomic analyses of non-mucoid and mucoid Pseudomonas aeruginosa clinical isolates from a cystic fibrosis patient Frontiers in Microbiology. 2: 1-12. DOI: 10.3389/fmicb.2011.00162  0.443
2008 Rao J, DiGiandomenico A, Unger J, Bao Y, Polanowska-Grabowska RK, Goldberg JB. A novel oxidized low-density lipoprotein-binding protein from Pseudomonas aeruginosa. Microbiology (Reading, England). 154: 654-65. PMID 18227268 DOI: 10.1099/Mic.0.2007/011429-0  0.534
2008 Kintz E, Scarff JM, DiGiandomenico A, Goldberg JB. Lipopolysaccharide O-antigen chain length regulation in Pseudomonas aeruginosa serogroup O11 strain PA103. Journal of Bacteriology. 190: 2709-16. PMID 18065548 DOI: 10.1128/Jb.01646-07  0.696
2007 DiGiandomenico A, Rao J, Harcher K, Zaidi TS, Gardner J, Neely AN, Pier GB, Goldberg JB. Intranasal immunization with heterologously expressed polysaccharide protects against multiple Pseudomonas aeruginosa infections. Proceedings of the National Academy of Sciences of the United States of America. 104: 4624-9. PMID 17360574 DOI: 10.1073/Pnas.0608657104  0.643
2004 DiGiandomenico A, Rao J, Goldberg JB. Oral vaccination of BALB/c mice with Salmonella enterica serovar Typhimurium expressing Pseudomonas aeruginosa O antigen promotes increased survival in an acute fatal pneumonia model. Infection and Immunity. 72: 7012-21. PMID 15557624 DOI: 10.1128/Iai.72.12.7012-7021.2004  0.66
2002 DiGiandomenico A, Matewish MJ, Bisaillon A, Stehle JR, Lam JS, Castric P. Glycosylation of Pseudomonas aeruginosa 1244 pilin: glycan substrate specificity. Molecular Microbiology. 46: 519-30. PMID 12406226 DOI: 10.1046/J.1365-2958.2002.03171.X  0.482
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