| Year |
Citation |
Score |
| 2023 |
Sharma R, Hartman TE, Beites T, Kim JH, Eoh H, Engelhart CA, Zhu L, Wilson DJ, Aldrich CC, Ehrt S, Rhee KY, Schnappinger D. Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in . Mbio. e0034023. PMID 37350592 DOI: 10.1128/mbio.00340-23 |
0.506 |
|
| 2022 |
Green SR, Davis SH, Damerow S, Engelhart CA, Mathieson M, Baragaña B, Robinson DA, Tamjar J, Dawson A, Tamaki FK, Buchanan KI, Post J, Dowers K, Shepherd SM, Jansen C, ... ... Schnappinger D, et al. Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs. Nature Communications. 13: 5992. PMID 36220877 DOI: 10.1038/s41467-022-33736-5 |
0.319 |
|
| 2022 |
Li S, Poulton NC, Chang JS, Azadian ZA, DeJesus MA, Ruecker N, Zimmerman MD, Eckartt KA, Bosch B, Engelhart CA, Sullivan DF, Gengenbacher M, Dartois VA, Schnappinger D, Rock JM. CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis. Nature Microbiology. 7: 766-779. PMID 35637331 DOI: 10.1038/s41564-022-01130-y |
0.309 |
|
| 2022 |
Kreutzfeldt KM, Jansen RS, Hartman TE, Gouzy A, Wang R, Krieger IV, Zimmerman MD, Gengenbacher M, Sarathy JP, Xie M, Dartois V, Sacchettini JC, Rhee KY, Schnappinger D, Ehrt S. CinA mediates multidrug tolerance in Mycobacterium tuberculosis. Nature Communications. 13: 2203. PMID 35459278 DOI: 10.1038/s41467-022-29832-1 |
0.341 |
|
| 2021 |
Beites T, Jansen RS, Wang R, Jinich A, Rhee KY, Schnappinger D, Ehrt S. Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection. Nature Communications. 12: 6593. PMID 34782606 DOI: 10.1038/s41467-021-26941-1 |
0.321 |
|
| 2021 |
Bosch B, DeJesus MA, Poulton NC, Zhang W, Engelhart CA, Zaveri A, Lavalette S, Ruecker N, Trujillo C, Wallach JB, Li S, Ehrt S, Chait BT, Schnappinger D, Rock JM. Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis. Cell. PMID 34297925 DOI: 10.1016/j.cell.2021.06.033 |
0.33 |
|
| 2021 |
Wang H, Xu M, Engelhart CA, Zhang X, Yan B, Pan M, Xu Y, Fan S, Liu R, Xu L, Hua L, Schnappinger D, Chen S. Rediscovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis. The Journal of Biological Chemistry. 296: 100257. PMID 33837735 DOI: 10.1016/j.jbc.2021.100257 |
0.328 |
|
| 2021 |
Ray PC, Huggett M, Turner PA, Taylor M, Cleghorn LAT, Early J, Kumar A, Bonnett SA, Flint L, Joerss D, Johnson J, Korkegian A, Mullen S, Moure AL, Davis SH, ... ... Schnappinger D, et al. Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Growth. Acs Omega. 6: 2284-2311. PMID 33521468 DOI: 10.1021/acsomega.0c05589 |
0.304 |
|
| 2021 |
Wang H, Xu M, Engelhart CA, Zhang X, Yan B, Pan M, Xu Y, Fan S, Liu R, Xu L, Hua L, Schnappinger D, Chen S. Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in . The Journal of Biological Chemistry. PMID 33397709 DOI: 10.1074/jbc.RA120.016477 |
0.306 |
|
| 2020 |
Lee BS, Hards K, Engelhart CA, Hasenoehrl EJ, Kalia NP, Mackenzie JS, Sviriaeva E, Chong SMS, Manimekalai MSS, Koh VH, Chan J, Xu J, Alonso S, Miller MJ, Steyn AJC, ... ... Schnappinger D, et al. Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis. Embo Molecular Medicine. e13207. PMID 33283973 DOI: 10.15252/emmm.202013207 |
0.304 |
|
| 2020 |
Zaveri A, Wang R, Botella L, Sharma R, Zhu L, Wallach JB, Song N, Jansen RS, Rhee KY, Ehrt S, Schnappinger D. Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA-damage response and leads to cell death. Molecular Microbiology. PMID 32634279 DOI: 10.1111/Mmi.14571 |
0.329 |
|
| 2020 |
Gengenbacher M, Zimmerman MD, Sarathy JP, Kaya F, Wang H, Mina M, Carter C, Hossen MA, Su H, Trujillo C, Ehrt S, Schnappinger D, Dartois V. Tissue distribution of doxycycline in animal models of tuberculosis. Antimicrobial Agents and Chemotherapy. PMID 32041718 DOI: 10.1128/Aac.02479-19 |
0.355 |
|
| 2019 |
Wang R, Kreutzfeldt K, Botella H, Vaubourgeix J, Schnappinger D, Ehrt S. Persistent infection in mice requires PerM for successful cell division. Elife. 8. PMID 31751212 DOI: 10.7554/Elife.49570 |
0.363 |
|
| 2019 |
Beites T, O'Brien K, Tiwari D, Engelhart CA, Walters S, Andrews J, Yang HJ, Sutphen ML, Weiner DM, Dayao EK, Zimmerman M, Prideaux B, Desai PV, Masquelin T, Via LE, ... ... Schnappinger D, et al. Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development. Nature Communications. 10: 4970. PMID 31672993 DOI: 10.1038/S41467-019-12956-2 |
0.442 |
|
| 2019 |
Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez JE, Audette RE, Bandyopadhyay N, Betancourt N, Delano K, Da Silva I, Davis J, Gallo C, Gardner M, ... ... Schnappinger D, et al. Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes. Nature. PMID 31217586 DOI: 10.1038/S41586-019-1315-Z |
0.376 |
|
| 2019 |
Freire DM, Gutierrez C, Garza-Garcia A, Grabowska AD, Sala AJ, Ariyachaokun K, Panikova T, Beckham KSH, Colom A, Pogenberg V, Cianci M, Tuukkanen A, Boudehen YM, Peixoto A, Botella L, ... ... Schnappinger D, et al. An NAD Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death. Molecular Cell. PMID 30792174 DOI: 10.1016/J.Molcel.2019.01.028 |
0.463 |
|
| 2019 |
Ballinger E, Mosior J, Hartman T, Burns-Huang K, Gold B, Morris R, Goullieux L, Blanc I, Vaubourgeix J, Lagrange S, Fraisse L, Sans S, Couturier C, Bacqué E, Rhee K, ... ... Schnappinger D, et al. Opposing reactions in coenzyme A metabolism sensitize to enzyme inhibition. Science (New York, N.Y.). 363. PMID 30705156 DOI: 10.1126/Science.Aau8959 |
0.375 |
|
| 2019 |
Bockman MR, Engelhart CA, Cramer JD, Howe M, Mishra N, Zimmerman M, Larson P, Alvarez-Cabrera N, Park SW, Boshoff HIM, Bean JM, Young V, Ferguson DM, Dartois V, Jarrett JT, ... Schnappinger D, et al. Investigation of (S)-(-)-acidomycin: A selective antimycobacterial natural product that inhibits biotin synthase. Acs Infectious Diseases. PMID 30652474 DOI: 10.1021/Acsinfecdis.8B00345 |
0.45 |
|
| 2019 |
Wang R, Kreutzfeldt K, Botella H, Vaubourgeix J, Schnappinger D, Ehrt S. Author response: Persistent Mycobacterium tuberculosis infection in mice requires PerM for successful cell division Elife. DOI: 10.7554/Elife.49570.Sa2 |
0.376 |
|
| 2018 |
Wescott HH, Zuniga ES, Bajpai A, Trujillo C, Ehrt S, Schnappinger D, Roberts DM, Parish T. Identification of Enolase as the Target of 2-Aminothiazoles in . Frontiers in Microbiology. 9: 2542. PMID 30416491 DOI: 10.3389/Fmicb.2018.02542 |
0.398 |
|
| 2018 |
Oh S, Park Y, Engelhart CA, Wallach JB, Schnappinger D, Arora K, Manikkam M, Gac B, Wang H, Murgolo N, Olsen DB, Goodwin M, Sutphin M, Weiner DM, Via LE, et al. Discovery of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-D-ribose 2'-oxidase (DprE1) and Their Structure-activity Relationship Study. Journal of Medicinal Chemistry. PMID 30350998 DOI: 10.1021/Acs.Jmedchem.8B00883 |
0.375 |
|
| 2018 |
Tiwari D, Park SW, Essawy MM, Dawadi S, Mason A, Nandakumar M, Zimmerman M, Mina M, Ho HP, Engelhart CA, Ioerger T, Sacchettini JC, Rhee K, Ehrt S, Aldrich CC, ... ... Schnappinger D, et al. Targeting protein biotinylation enhances tuberculosis chemotherapy. Science Translational Medicine. 10. PMID 29695454 DOI: 10.1126/Scitranslmed.Aal1803 |
0.433 |
|
| 2018 |
Ehrt S, Schnappinger D, Rhee KY. Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis. Nature Reviews. Microbiology. PMID 29691481 DOI: 10.1038/S41579-018-0013-4 |
0.435 |
|
| 2018 |
Dawadi S, Boshoff HIM, Park SW, Schnappinger D, Aldrich CC. Conformationally Constrained Cinnolinone Nucleoside Analogues as Siderophore Biosynthesis Inhibitors for Tuberculosis. Acs Medicinal Chemistry Letters. 9: 386-391. PMID 29670706 DOI: 10.1021/Acsmedchemlett.8B00090 |
0.359 |
|
| 2018 |
Bockman MR, Engelhart CA, Dawadi S, Larson P, Tiwari D, Ferguson DM, Schnappinger D, Aldrich CC. Avoiding Antibiotic Inactivation in Mycobacterium tuberculosis by Rv3406 through Strategic Nucleoside Modification. Acs Infectious Diseases. PMID 29663798 DOI: 10.1021/Acsinfecdis.8B00038 |
0.422 |
|
| 2018 |
Ngadjeua F, Braud E, Saidjalolov S, Iannazzo L, Schnappinger D, Ehrt S, Hugonnet JE, Mengin-Lecreulx D, Patin DP, Ethève-Quelquejeu M, Fonvielle M, Arthur M. Critical impact of peptidoglycan precursor amidation on the activity of L,D-transpeptidases from Enterococcus faecium and Mycobacterium tuberculosis. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29389045 DOI: 10.1002/Chem.201706082 |
0.364 |
|
| 2017 |
Xu W, DeJesus MA, Rücker N, Engelhart CA, Wright MG, Healy C, Lin K, Wang R, Park SW, Ioerger TR, Schnappinger D, Ehrt S. Chemical genomic interaction profiling reveals determinants of intrinsic antibiotic resistance in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. PMID 28893793 DOI: 10.1128/Aac.01334-17 |
0.458 |
|
| 2017 |
Liu F, Dawadi S, Maize KM, Dai R, Park SW, Schnappinger D, Finzel BC, Aldrich CC. Structure-Based Optimization of Pyridoxal 5'-Phosphate (PLP)-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis. Journal of Medicinal Chemistry. PMID 28594172 DOI: 10.1021/Acs.Jmedchem.7B00189 |
0.417 |
|
| 2017 |
Botella L, Vaubourgeix J, Livny J, Schnappinger D. Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death. Nature Communications. 8: 14731. PMID 28348398 DOI: 10.1038/Ncomms14731 |
0.43 |
|
| 2017 |
Puckett S, Trujillo C, Wang Z, Eoh H, Ioerger TR, Krieger I, Sacchettini J, Schnappinger D, Rhee KY, Ehrt S. Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28265055 DOI: 10.1073/Pnas.1617655114 |
0.384 |
|
| 2017 |
Rock JM, Hopkins FF, Chavez A, Diallo M, Chase MR, Gerrick ER, Pritchard JR, Church GM, Rubin EJ, Sassetti CM, Schnappinger D, Fortune SM. Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform. Nature Microbiology. 2: 16274. PMID 28165460 DOI: 10.1038/Nmicrobiol.2016.274 |
0.468 |
|
| 2017 |
DeJesus MA, Gerrick ER, Xu W, Park SW, Long JE, Boutte CC, Rubin EJ, Schnappinger D, Ehrt S, Fortune SM, Sassetti CM, Ioerger TR. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mbio. 8. PMID 28096490 DOI: 10.1128/Mbio.02133-16 |
0.365 |
|
| 2016 |
Schnappinger D, Ehrt S. A broader spectrum of tuberculosis. Nature Medicine. 22: 1076-1077. PMID 27711059 DOI: 10.1038/Nm.4186 |
0.404 |
|
| 2016 |
Evans JC, Trujillo C, Wang Z, Eoh H, Ehrt S, Schnappinger D, Boshoff HI, Rhee KY, Barry 3rd CE, Mizrahi V. Validation of CoaBC as a bactericidal target in the coenzyme A pathway of Mycobacterium tuberculosis. Acs Infectious Diseases. PMID 27676316 DOI: 10.1021/Acsinfecdis.6B00150 |
0.491 |
|
| 2016 |
Li W, Obregón-Henao A, Wallach JB, North EJ, Lee RE, Gonzalez-Juarrero M, Schnappinger D, Jackson M. Therapeutic potential of the Mycobacterium tuberculosis mycolic acid transporter, MmpL3. Antimicrobial Agents and Chemotherapy. PMID 27297488 DOI: 10.1128/Aac.00826-16 |
0.482 |
|
| 2016 |
Lin K, O'Brien KM, Trujillo C, Wang R, Wallach JB, Schnappinger D, Ehrt S. Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense. Plos Pathogens. 12: e1005675. PMID 27249779 DOI: 10.1371/Journal.Ppat.1005675 |
0.428 |
|
| 2016 |
Chauhan R, Ravi J, Datta P, Chen T, Schnappinger D, Bassler KE, Balázsi G, Gennaro ML. Reconstruction and topological characterization of the sigma factor regulatory network of Mycobacterium tuberculosis. Nature Communications. 7: 11062. PMID 27029515 DOI: 10.1038/Ncomms11062 |
0.339 |
|
| 2016 |
Mizrahi V, Evans J, Trujillo C, Eoh H, Ehrt S, Schnappinger D, Boshoff H, Rhee K, Barry CE. Identifying vulnerable steps in the coenzyme A biosynthesis pathway of M. tuberculosis The Faseb Journal. 30. DOI: 10.1096/Fasebj.30.1_Supplement.242.2 |
0.423 |
|
| 2015 |
Bockman MR, Kalinda AS, Petrelli R, De la Mora-Rey T, Tiwari D, Liu F, Dawadi S, Nandakumar M, Rhee KY, Schnappinger D, Finzel BC, Aldrich CC. Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors. Journal of Medicinal Chemistry. 58: 7349-69. PMID 26299766 DOI: 10.1021/Acs.Jmedchem.5B00719 |
0.432 |
|
| 2015 |
Dai R, Geders TW, Liu F, Park SW, Schnappinger D, Aldrich CC, Finzel BC. Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA. Journal of Medicinal Chemistry. 58: 5208-17. PMID 26068403 DOI: 10.1021/Acs.Jmedchem.5B00092 |
0.342 |
|
| 2015 |
Schnappinger D, O'Brien KM, Ehrt S. Construction of conditional knockdown mutants in mycobacteria. Methods in Molecular Biology (Clifton, N.J.). 1285: 151-75. PMID 25779315 DOI: 10.1007/978-1-4939-2450-9_9 |
0.412 |
|
| 2015 |
Ehrt S, Rhee K, Schnappinger D. Mycobacterial genes essential for the pathogen's survival in the host. Immunological Reviews. 264: 319-26. PMID 25703569 DOI: 10.1111/Imr.12256 |
0.366 |
|
| 2015 |
Schnappinger D. Genetic Approaches to Facilitate Antibacterial Drug Development. Cold Spring Harbor Perspectives in Medicine. 5: a021139. PMID 25680982 DOI: 10.1101/Cshperspect.A021139 |
0.357 |
|
| 2015 |
Goodsmith N, Guo XV, Vandal OH, Vaubourgeix J, Wang R, Botella H, Song S, Bhatt K, Liba A, Salgame P, Schnappinger D, Ehrt S. Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice. Plos Pathogens. 11: e1004645. PMID 25658098 DOI: 10.1371/Journal.Ppat.1004645 |
0.451 |
|
| 2015 |
Vaubourgeix J, Lin G, Dhar N, Chenouard N, Jiang X, Botella H, Lupoli T, Mariani O, Yang G, Ouerfelli O, Unser M, Schnappinger D, McKinney J, Nathan C. Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells. Cell Host & Microbe. 17: 178-90. PMID 25620549 DOI: 10.1016/J.Chom.2014.12.008 |
0.369 |
|
| 2015 |
Park SW, Casalena DE, Wilson DJ, Dai R, Nag PP, Liu F, Boyce JP, Bittker JA, Schreiber SL, Finzel BC, Schnappinger D, Aldrich CC. Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis. Chemistry & Biology. 22: 76-86. PMID 25556942 DOI: 10.1016/J.Chembiol.2014.11.012 |
0.418 |
|
| 2014 |
Schnappinger D, Ehrt S. Regulated Expression Systems for Mycobacteria and Their Applications. Microbiology Spectrum. 2: MGM2-0018-2013. PMID 26082123 DOI: 10.1128/Microbiolspec.Mgm2-0018-2013 |
0.364 |
|
| 2014 |
Puckett S, Trujillo C, Eoh H, Marrero J, Spencer J, Jackson M, Schnappinger D, Rhee K, Ehrt S. Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis. Plos Pathogens. 10: e1004144. PMID 24851864 DOI: 10.1371/Journal.Ppat.1004144 |
0.393 |
|
| 2014 |
Trujillo C, Blumenthal A, Marrero J, Rhee KY, Schnappinger D, Ehrt S. Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection. Mbio. 5: e00085. PMID 24757211 DOI: 10.1128/Mbio.00085-14 |
0.431 |
|
| 2014 |
Raju RM, Jedrychowski MP, Wei JR, Pinkham JT, Park AS, O'Brien K, Rehren G, Schnappinger D, Gygi SP, Rubin EJ. Post-translational regulation via Clp protease is critical for survival of Mycobacterium tuberculosis. Plos Pathogens. 10: e1003994. PMID 24603869 DOI: 10.1371/Journal.Ppat.1003994 |
0.411 |
|
| 2014 |
Gouzy A, Larrouy-Maumus G, Bottai D, Levillain F, Dumas A, Wallach JB, Caire-Brandli I, de Chastellier C, Wu TD, Poincloux R, Brosch R, Guerquin-Kern JL, Schnappinger D, Sório de Carvalho LP, Poquet Y, et al. Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection. Plos Pathogens. 10: e1003928. PMID 24586151 DOI: 10.1371/Journal.Ppat.1003928 |
0.465 |
|
| 2013 |
Shi C, Tiwari D, Wilson DJ, Seiler CL, Schnappinger D, Aldrich CC. Bisubstrate Inhibitors of Biotin Protein Ligase in Mycobacterium tuberculosis Resistant to Cyclonucleoside Formation. Acs Medicinal Chemistry Letters. 4. PMID 24363833 DOI: 10.1021/Ml400328A |
0.443 |
|
| 2013 |
Kim JH, O'Brien KM, Sharma R, Boshoff HI, Rehren G, Chakraborty S, Wallach JB, Monteleone M, Wilson DJ, Aldrich CC, Barry CE, Rhee KY, Ehrt S, Schnappinger D. A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence. Proceedings of the National Academy of Sciences of the United States of America. 110: 19095-100. PMID 24191058 DOI: 10.1073/Pnas.1315860110 |
0.598 |
|
| 2013 |
Lew JM, Mao C, Shukla M, Warren A, Will R, Kuznetsov D, Xenarios I, Robertson BD, Gordon SV, Schnappinger D, Cole ST, Sobral B. Database resources for the tuberculosis community. Tuberculosis (Edinburgh, Scotland). 93: 12-7. PMID 23332401 DOI: 10.1016/J.Tube.2012.11.003 |
0.359 |
|
| 2012 |
Robertson BD, Altmann D, Barry C, Bishai B, Cole S, Dick T, Duncan K, Dye C, Ehrt S, Esmail H, Flynn J, Hafner R, Handley G, Hanekom W, van Helden P, ... ... Schnappinger D, et al. Detection and treatment of subclinical tuberculosis. Tuberculosis (Edinburgh, Scotland). 92: 447-52. PMID 22819716 DOI: 10.1016/J.Tube.2012.06.004 |
0.373 |
|
| 2012 |
Wilson M, Voskuil M, Schnappinger D, Schoolnik GK. Functional Genomics of Mycobacterium tuberculosis Using DNA Microarrays. Methods in Molecular Medicine. 54: 335-57. PMID 21341086 DOI: 10.1385/1-59259-147-7:335 |
0.373 |
|
| 2011 |
Duckworth BP, Geders TW, Tiwari D, Boshoff HI, Sibbald PA, Barry CE, Schnappinger D, Finzel BC, Aldrich CC. Bisubstrate adenylation inhibitors of biotin protein ligase from Mycobacterium tuberculosis. Chemistry & Biology. 18: 1432-41. PMID 22118677 DOI: 10.1016/J.Chembiol.2011.08.013 |
0.414 |
|
| 2011 |
Shi C, Geders TW, Park SW, Wilson DJ, Boshoff HI, Abayomi O, Barry CE, Schnappinger D, Finzel BC, Aldrich CC. Mechanism-based inactivation by aromatization of the transaminase BioA involved in biotin biosynthesis in Mycobaterium tuberculosis. Journal of the American Chemical Society. 133: 18194-201. PMID 21988601 DOI: 10.1021/Ja204036T |
0.388 |
|
| 2011 |
Woong Park S, Klotzsche M, Wilson DJ, Boshoff HI, Eoh H, Manjunatha U, Blumenthal A, Rhee K, Barry CE, Aldrich CC, Ehrt S, Schnappinger D. Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression. Plos Pathogens. 7: e1002264. PMID 21980288 DOI: 10.1371/Journal.Ppat.1002264 |
0.498 |
|
| 2011 |
de la Paz Santangelo M, Gest PM, Guerin ME, Coinçon M, Pham H, Ryan G, Puckett SE, Spencer JS, Gonzalez-Juarrero M, Daher R, Lenaerts AJ, Schnappinger D, Therisod M, Ehrt S, Sygusch J, et al. Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli. The Journal of Biological Chemistry. 286: 40219-31. PMID 21949126 DOI: 10.1074/Jbc.M111.259440 |
0.466 |
|
| 2011 |
Williams KJ, Boshoff HI, Krishnan N, Gonzales J, Schnappinger D, Robertson BD. The Mycobacterium tuberculosis β-oxidation genes echA5 and fadB3 are dispensable for growth in vitro and in vivo. Tuberculosis (Edinburgh, Scotland). 91: 549-55. PMID 21764638 DOI: 10.1016/J.Tube.2011.06.006 |
0.386 |
|
| 2011 |
Rhee KY, de Carvalho LP, Bryk R, Ehrt S, Marrero J, Park SW, Schnappinger D, Venugopal A, Nathan C. Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends in Microbiology. 19: 307-14. PMID 21561773 DOI: 10.1016/J.Tim.2011.03.008 |
0.397 |
|
| 2011 |
Wei JR, Krishnamoorthy V, Murphy K, Kim JH, Schnappinger D, Alber T, Sassetti CM, Rhee KY, Rubin EJ. Depletion of antibiotic targets has widely varying effects on growth. Proceedings of the National Academy of Sciences of the United States of America. 108: 4176-81. PMID 21368134 DOI: 10.1073/Pnas.1018301108 |
0.484 |
|
| 2011 |
Venugopal A, Bryk R, Shi S, Rhee K, Rath P, Schnappinger D, Ehrt S, Nathan C. Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes. Cell Host & Microbe. 9: 21-31. PMID 21238944 DOI: 10.1016/J.Chom.2010.12.004 |
0.43 |
|
| 2011 |
Kim JH, Wei JR, Wallach JB, Robbins RS, Rubin EJ, Schnappinger D. Protein inactivation in mycobacteria by controlled proteolysis and its application to deplete the beta subunit of RNA polymerase. Nucleic Acids Research. 39: 2210-20. PMID 21075796 DOI: 10.1093/Nar/Gkq1149 |
0.502 |
|
| 2010 |
Blumenthal A, Trujillo C, Ehrt S, Schnappinger D. Simultaneous analysis of multiple Mycobacterium tuberculosis knockdown mutants in vitro and in vivo. Plos One. 5: e15667. PMID 21203517 DOI: 10.1371/Journal.Pone.0015667 |
0.412 |
|
| 2010 |
Beaulieu AM, Rath P, Imhof M, Siddall ME, Roberts J, Schnappinger D, Nathan CF. Genome-wide screen for Mycobacterium tuberculosis genes that regulate host immunity. Plos One. 5: e15120. PMID 21170273 DOI: 10.1371/Journal.Pone.0015120 |
0.413 |
|
| 2010 |
Tan MP, Sequeira P, Lin WW, Phong WY, Cliff P, Ng SH, Lee BH, Camacho L, Schnappinger D, Ehrt S, Dick T, Pethe K, Alonso S. Nitrate respiration protects hypoxic Mycobacterium tuberculosis against acid- and reactive nitrogen species stresses. Plos One. 5: e13356. PMID 21048946 DOI: 10.1371/Journal.Pone.0013356 |
0.405 |
|
| 2010 |
Marrero J, Rhee KY, Schnappinger D, Pethe K, Ehrt S. Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection. Proceedings of the National Academy of Sciences of the United States of America. 107: 9819-24. PMID 20439709 DOI: 10.1073/Pnas.1000715107 |
0.383 |
|
| 2010 |
Barry CE, Boshoff HI, Dartois V, Dick T, Ehrt S, Flynn J, Schnappinger D, Wilkinson RJ, Young D. Spectrum of latent tuberculosis existing tests cannot resolve the underlying phenotypes: Author's reply Nature Reviews Microbiology. 8: 242. DOI: 10.1038/Nrmicro2236-C2 |
0.34 |
|
| 2009 |
Barry CE, Boshoff HI, Dartois V, Dick T, Ehrt S, Flynn J, Schnappinger D, Wilkinson RJ, Young D. The spectrum of latent tuberculosis: rethinking the biology and intervention strategies. Nature Reviews. Microbiology. 7: 845-55. PMID 19855401 DOI: 10.1038/Nrmicro2236 |
0.426 |
|
| 2009 |
Ehrt S, Schnappinger D. Mycobacterial survival strategies in the phagosome: defence against host stresses. Cellular Microbiology. 11: 1170-8. PMID 19438516 DOI: 10.1111/J.1462-5822.2009.01335.X |
0.403 |
|
| 2009 |
Klotzsche M, Ehrt S, Schnappinger D. Improved tetracycline repressors for gene silencing in mycobacteria. Nucleic Acids Research. 37: 1778-88. PMID 19174563 DOI: 10.1093/Nar/Gkp015 |
0.407 |
|
| 2009 |
Vandal OH, Roberts JA, Odaira T, Schnappinger D, Nathan CF, Ehrt S. Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment. Journal of Bacteriology. 191: 625-31. PMID 19011036 DOI: 10.1128/Jb.00932-08 |
0.413 |
|
| 2008 |
Vandal OH, Pierini LM, Schnappinger D, Nathan CF, Ehrt S. A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis. Nature Medicine. 14: 849-54. PMID 18641659 DOI: 10.1038/Nm.1795 |
0.381 |
|
| 2008 |
Boshoff HI, Xu X, Tahlan K, Dowd CS, Pethe K, Camacho LR, Park TH, Yun CS, Schnappinger D, Ehrt S, Williams KJ, Barry CE. Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli. The Journal of Biological Chemistry. 283: 19329-41. PMID 18490451 DOI: 10.1074/Jbc.M800694200 |
0.493 |
|
| 2007 |
Gandotra S, Schnappinger D, Monteleone M, Hillen W, Ehrt S. In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice. Nature Medicine. 13: 1515-20. PMID 18059281 DOI: 10.1038/Nm1683 |
0.468 |
|
| 2007 |
Guo XV, Monteleone M, Klotzsche M, Kamionka A, Hillen W, Braunstein M, Ehrt S, Schnappinger D. Silencing Mycobacterium smegmatis by using tetracycline repressors. Journal of Bacteriology. 189: 4614-23. PMID 17483222 DOI: 10.1128/Jb.00216-07 |
0.371 |
|
| 2007 |
Ehrt S, Schnappinger D. Mycobacterium tuberculosis virulence: lipids inside and out. Nature Medicine. 13: 284-5. PMID 17342139 DOI: 10.1038/Nm0307-284 |
0.37 |
|
| 2007 |
Schnappinger D. Genomics of host-pathogen interactions. Progress in Drug Research. Fortschritte Der Arzneimittelforschung. ProgrèS Des Recherches Pharmaceutiques. 64: 311, 313-43. PMID 17195480 DOI: 10.1007/978-3-7643-7567-6_12 |
0.322 |
|
| 2006 |
Ehrt S, Schnappinger D. Controlling gene expression in mycobacteria. Future Microbiology. 1: 177-84. PMID 17661663 DOI: 10.2217/17460913.1.2.177 |
0.421 |
|
| 2006 |
Schnappinger D, Schoolnik GK, Ehrt S. Expression profiling of host pathogen interactions: how Mycobacterium tuberculosis and the macrophage adapt to one another. Microbes and Infection / Institut Pasteur. 8: 1132-40. PMID 16517202 DOI: 10.1016/J.Micinf.2005.10.027 |
0.432 |
|
| 2005 |
Morris RP, Nguyen L, Gatfield J, Visconti K, Nguyen K, Schnappinger D, Ehrt S, Liu Y, Heifets L, Pieters J, Schoolnik G, Thompson CJ. Ancestral antibiotic resistance in Mycobacterium tuberculosis Proceedings of the National Academy of Sciences of the United States of America. 102: 12200-12205. PMID 16103351 DOI: 10.1073/Pnas.0505446102 |
0.466 |
|
| 2005 |
Ehrt S, Guo XV, Hickey CM, Ryou M, Monteleone M, Riley LW, Schnappinger D. Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor. Nucleic Acids Research. 33: e21. PMID 15687379 DOI: 10.1093/Nar/Gni013 |
0.404 |
|
| 2004 |
Voskuil MI, Schnappinger D, Rutherford R, Liu Y, Schoolnik GK. Regulation of the Mycobacterium tuberculosis PE/PPE genes. Tuberculosis (Edinburgh, Scotland). 84: 256-62. PMID 15207495 DOI: 10.1016/J.Tube.2003.12.014 |
0.358 |
|
| 2003 |
Shi S, Nathan C, Schnappinger D, Drenkow J, Fuortes M, Block E, Ding A, Gingeras TR, Schoolnik G, Akira S, Takeda K, Ehrt S. MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis. The Journal of Experimental Medicine. 198: 987-97. PMID 14517275 DOI: 10.1084/Jem.20030603 |
0.366 |
|
| 2003 |
Voskuil MI, Schnappinger D, Visconti KC, Harrell MI, Dolganov GM, Sherman DR, Schoolnik GK. Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program. The Journal of Experimental Medicine. 198: 705-13. PMID 12953092 DOI: 10.1084/Jem.20030205 |
0.445 |
|
| 2003 |
Schnappinger D, Ehrt S, Voskuil MI, Liu Y, Mangan JA, Monahan IM, Dolganov G, Efron B, Butcher PD, Nathan C, Schoolnik GK. Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. The Journal of Experimental Medicine. 198: 693-704. PMID 12953091 DOI: 10.1084/Jem.20030846 |
0.411 |
|
| 2003 |
Krueger C, Berens C, Schmidt A, Schnappinger D, Hillen W. Single-chain Tet transregulators. Nucleic Acids Research. 31: 3050-6. PMID 12799431 DOI: 10.1093/Nar/Gkg421 |
0.345 |
|
| 2002 |
Ehrt S, Schnappinger D, Voskuil MI, Schoolnik GK. Genome-wide expression profiling of intracellular bacteria: The interaction of Mycobacterium tuberculosis with macrophages Methods in Microbiology. 32: 169-180. DOI: 10.1016/S0580-9517(02)32092-0 |
0.375 |
|
| 2001 |
Kaps I, Ehrt S, Seeber S, Schnappinger D, Martin C, Riley LW, Niederweis M. Energy transfer between fluorescent proteins using a co-expression system in Mycobacterium smegmatis Gene. 278: 115-124. PMID 11707328 DOI: 10.1016/S0378-1119(01)00712-0 |
0.311 |
|
| 2001 |
Ehrt S, Schnappinger D, Bekiranov S, Drenkow J, Shi S, Gingeras TR, Gaasterland T, Schoolnik G, Nathan C. Reprogramming of the macrophage transcriptome in response to interferon-gamma and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase. The Journal of Experimental Medicine. 194: 1123-40. PMID 11602641 DOI: 10.1084/Jem.194.8.1123 |
0.383 |
|
| 2001 |
Sherman DR, Voskuil M, Schnappinger D, Liao R, Harrell MI, Schoolnik GK. Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha -crystallin. Proceedings of the National Academy of Sciences of the United States of America. 98: 7534-9. PMID 11416222 DOI: 10.1073/Pnas.121172498 |
0.433 |
|
| 2000 |
Orth P, Schnappinger D, Hillen W, Saenger W, Hinrichs W. Structural basis of gene regulation by the tetracycline inducible Tet repressor-operator system. Nature Structural & Molecular Biology. 7: 215-219. PMID 10700280 DOI: 10.1038/73324 |
0.319 |
|
| 1999 |
Baron U, Schnappinger D, Helbl V, Gossen M, Hillen W, Bujard H. Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes. Proceedings of the National Academy of Sciences of the United States of America. 96: 1013-8. PMID 9927685 DOI: 10.1073/Pnas.96.3.1013 |
0.328 |
|
| 1996 |
Schnappinger D, Hillen W. Tetracyclines: antibiotic action, uptake, and resistance mechanisms. Archives of Microbiology. 165: 359-69. PMID 8661929 DOI: 10.1007/S002030050339 |
0.33 |
|
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