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Jeremy A. Goettel, Ph.D. - Publications

Affiliations: 
2010 Vanderbilt University, Nashville, TN 
Area:
Cell Biology, Biochemistry
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43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Tyagi RK, Jacobse J, Li J, Allaman MM, Otipoby KL, Sampson ER, Wilson KT, Goettel JA. HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice. Frontiers in Immunology. 12: 630204. PMID 33717161 DOI: 10.3389/fimmu.2021.630204  0.307
2020 Jacobse J, Li J, Tyagi RK, Rings EHHM, Samsom JN, Goettel JA. 933 Interleukin-23 Receptor Signaling Modulates The Stability And Function Of Forkhead Box P3 Positive Regulatory T Cells Gastroenterology. 158. DOI: 10.1016/S0016-5085(20)31150-1  0.324
2019 Tyagi RK, Li J, Jacobse J, Snapper SB, Shouval DS, Goettel JA. Humanized Mouse Models of Genetic Immune Disorders and Hematological Malignancies. Biochemical Pharmacology. 113671. PMID 31634456 DOI: 10.1016/J.Bcp.2019.113671  0.323
2019 Tsou A, Goettel J, Biswas A, Kang YH, Saltzman J, Kelly R, Gringauz J, Shen Z, Fox J, Horwitz B, Snapper S. P155 Elucidating Interactions Between The Immune System And The Gut Microbiota In A Reductionist Murine Model Of Inflammatory Bowel Disease Gastroenterology. 156. DOI: 10.1053/J.Gastro.2019.01.241  0.301
2018 Ryzhakov G, West NR, Franchini F, Clare S, Ilott NE, Sansom SN, Bullers SJ, Pearson C, Costain A, Vaughan-Jackson A, Goettel JA, Ermann J, Horwitz BH, Buti L, Lu X, et al. Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis. Nature Communications. 9: 3797. PMID 30228258 DOI: 10.1038/S41467-018-06085-5  0.403
2018 Biswas A, Shouval DS, Griffith A, Goettel JA, Field M, Kang YH, Konnikova L, Janssen E, Redhu NS, Thrasher AJ, Chatila T, Kuchroo VK, Geha RS, Notarangelo LD, Pai SY, et al. WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis. Nature Communications. 9: 1779. PMID 29725003 DOI: 10.1038/S41467-018-03670-6  0.401
2017 Shouval DS, Konnikova L, Griffith AE, Wall SM, Biswas A, Werner L, Nunberg M, Kammermeier J, Goettel JA, Anand R, Chen H, Weiss B, Li J, Loizides A, Yerushalmi B, et al. Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD. Inflammatory Bowel Diseases. PMID 29023267 DOI: 10.1097/Mib.0000000000001270  0.439
2017 Redhu NS, Bakthavatchalu V, Conaway EA, Shoval DS, Tsou AM, Goettel JA, Biswas A, Wang C, Field M, Muller W, Bleich A, Li N, Gerber GK, Bry L, Fox JG, et al. Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor. Elife. 6. PMID 28678006 DOI: 10.7554/Elife.27652  0.341
2017 Goettel J, Kotlarz D, Illig D, Canavan J, Allegretti J, Hamilton M, Kelly R, Griffith A, Carellas M, Nelina A, Bousvaros A, Korzenik J, Snapper S. O-011 Low-dose IL-2 Administration Expands Human Regulatory T Cells in Patients with UC and Humanized Mice and Protects Against Experimental Colitis. Inflammatory Bowel Diseases. 23: S4. PMID 28125559 DOI: 10.1097/01.Mib.0000512521.84210.0B  0.343
2017 Thiagarajah JR, Chang J, Goettel JA, Verkman AS, Lencer WI. Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia. Proceedings of the National Academy of Sciences of the United States of America. PMID 28049834 DOI: 10.1073/Pnas.1612921114  0.367
2017 Redhu NS, Bakthavatchalu V, Conaway EA, Shouval DS, Tsou A, Goettel JA, Biswas A, Wang C, Field M, Muller W, Bleich A, Li N, Gerber GK, Bry L, Fox JG, et al. Author response: Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor Elife. DOI: 10.7554/Elife.27652.021  0.313
2017 Biswas A, Goettel JA, Kang YH, Redhu NS, Field M, Kelly R, Snapper SB. Wiskott-Aldrich Syndrome Protein (WASP) is Critical for Generation and Function of Innate Lymphoid Cells (ILC) Gastroenterology. 152. DOI: 10.1016/S0016-5085(17)30780-1  0.318
2016 Goettel JA, Gandhi R, Kenison JE, Yeste A, Murugaiyan G, Sambanthamoorthy S, Griffith AE, Patel B, Shouval DS, Weiner HL, Snapper SB, Quintana FJ. AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice. Cell Reports. 17: 1318-1329. PMID 27783946 DOI: 10.1016/J.Celrep.2016.09.082  0.378
2016 Lexmond WS, Goettel JA, Lyons JJ, Jacobse J, Deken MM, Lawrence MG, DiMaggio TH, Kotlarz D, Garabedian E, Sackstein P, Nelson CC, Jones N, Stone KD, Candotti F, Rings EH, et al. FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy. The Journal of Clinical Investigation. PMID 27643438 DOI: 10.1172/Jci85129  0.361
2016 Biswas A, Shouval D, Goettel J, Field M, Griffith A, Pai SY, Notarangelo L, Geha R, Snapper S. O-008 Aberrant Anti-inflammatory Macrophage Function and Differentiation in Wiskott-Aldrich Syndrome Protein-Deficient Mice and Humans. Inflammatory Bowel Diseases. 22: S3. PMID 26849726 DOI: 10.1097/01.Mib.0000480046.11503.1E  0.339
2016 Sugimura R, Han A, Jha D, Lu Y, Goettel JA, Serrao E, Rowe RG, Wong I, Sousa P, Ditadi A, Keller G, Engelman A, Snapper S, Doulatov S, Daley GQ. Hematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells Via Transcription Factor Conversion of Hemogenic Endothelium Blood. 128: 371-371. DOI: 10.1182/Blood.V128.22.371.371  0.368
2016 Goettel JA, Gandhi R, Yeste A, Sambanthamoorthy S, Patel B, Weiner H, Quintana FJ, Snapper SB. 765 A Non-Toxic Aryl Hydrocarbon Receptor Agonist Suppresses Colitis Driven by Human T-Cells in Human Leukocyte Antigen-DR1 Transgenic Humanized Mice Gastroenterology. 150. DOI: 10.1016/S0016-5085(16)30620-5  0.332
2016 Frei SM, Shouval DS, Biswas A, Goettel JA, Kang YH, Wu C, Kuchroo V, Snapper SB. 194 Interleukin-23 Receptor Signaling on CD4+ T Cells Is Required for Colitis Mediated by Interleukin-10 Receptor-Deficient Innate Immune Cells Gastroenterology. 150: S51. DOI: 10.1016/S0016-5085(16)30295-5  0.369
2015 Goettel JA, Biswas S, Lexmond WS, Yeste A, Passerini L, Patel B, Yang S, Sun J, Ouahed J, Shouval DS, McCann KJ, Horwitz BH, Mathis D, Milford EL, Notarangelo LD, et al. Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3. Blood. 125: 3886-95. PMID 25833964 DOI: 10.1182/Blood-2014-12-618363  0.364
2015 Goettel JA, Lexmond WS, Biswas A, Fiebiger E, Snapper SB. Mo1688 Human CD4 T-Cell-Mediated Cytokine Storm and Enterocolitis Following T-Cell Activation in Humanized Mice Gastroenterology. 148. DOI: 10.1016/S0016-5085(15)32318-0  0.366
2014 Vucovich MM, Cotton RB, Shelton EL, Goettel JA, Ehinger NJ, Poole SD, Brown N, Wynn JL, Paria BC, Slaughter JC, Clark RH, Rojas MA, Reese J. Aminoglycoside-mediated relaxation of the ductus arteriosus in sepsis-associated PDA. American Journal of Physiology. Heart and Circulatory Physiology. 307: H732-40. PMID 24993047 DOI: 10.1152/Ajpheart.00838.2013  0.315
2014 Shouval DS, Biswas A, Goettel JA, McCann K, Conaway E, Redhu NS, Mascanfroni ID, Al Adham Z, Lavoie S, Ibourk M, Nguyen DD, Samsom JN, Escher JC, Somech R, Weiss B, et al. Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function. Immunity. 40: 706-19. PMID 24792912 DOI: 10.1016/J.Immuni.2014.03.011  0.436
2014 Shouval DS, Ouahed J, Biswas A, Goettel JA, Horwitz BH, Klein C, Muise AM, Snapper SB. Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans. Advances in Immunology. 122: 177-210. PMID 24507158 DOI: 10.1016/B978-0-12-800267-4.00005-5  0.383
2014 Shouval DS, Biswas A, Goettel JA, McCann K, Conaway E, Samsom JN, Escher JC, Weiss B, Somech R, Beier R, Conklin L, Ebens CL, Bhan AK, Klein C, Muise A, et al. 785 Anti-Inflammatory Macrophage Function Requires IL10 Receptor Signaling and Regulates Mucosal Homeostasis in Mice and Humans Gastroenterology. 146. DOI: 10.1016/S0016-5085(14)60473-X  0.395
2014 Goettel JA, Biswas S, Lexmond WS, Sun J, Ouahed J, McCann K, Shouval DS, Milford E, Fiebiger E, Muise A, Marasco WA, Pai S, Norarangelo LD, Snapper SB. 363 Human Hematopoietic Stem Cells With a Defined Immunodeficiency and Enteropathy Transfer Clinical Phenotype to a Novel Humanized Mouse Strain Gastroenterology. 146. DOI: 10.1016/S0016-5085(14)60289-4  0.385
2013 Nguyen DD, Muthupalani S, Goettel JA, Eston MA, Mobley M, Taylor NS, McCabe A, Marin R, Snapper SB, Fox JG. Colitis and colon cancer in WASP-deficient mice require helicobacter species. Inflammatory Bowel Diseases. 19: 2041-50. PMID 23820270 DOI: 10.1097/Mib.0B013E318295Fd8F  0.36
2013 Weitkamp JH, Koyama T, Rock MT, Correa H, Goettel JA, Matta P, Oswald-Richter K, Rosen MJ, Engelhardt BG, Moore DJ, Polk DB. Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)/effector (CD4, CD8) T cell ratios. Gut. 62: 73-82. PMID 22267598 DOI: 10.1136/Gutjnl-2011-301551  0.32
2013 Shouval D, Biswas A, Goettel J, McCann K, Conaway E, Lavoie S, Samsom J, Escher J, Somech R, Weiss B, Conklin L, Bhan A, Muise A, Horwitz B, Snapper S. O-022 YI Innate Immune IL10 Receptor Signaling Regulates Mucosal Homeostasis and the Function of Anti-inflammatory Macrophages Inflammatory Bowel Diseases. 19. DOI: 10.1097/01.Mib.0000438573.48506.67  0.366
2013 Goettel JA, Ouahed J, McCann K, Muise AM, Snapper S. Mo1976 Development of Novel Humanized Murine Models to Assess Mucosal Homeostasis: Human T Cells From Ipex (Immunodeficiency, Polyendocrinopathy, Enteropathy, X-Linked) Patients Transfer Clinical Phenotype to Immunodeficient Mice Expressing Human Class II Gastroenterology. 144. DOI: 10.1016/S0016-5085(13)62628-1  0.325
2013 Shouval DS, Goettel JA, Wurbel M, Muise AM, Snapper SB. 158 Innate IL-10 Receptor Signaling Regulates Intestinal Mucosal Homeostasis Gastroenterology. 144. DOI: 10.1016/S0016-5085(13)60129-8  0.339
2013 Goettel JA, Shouval DS, Lexmond W, Muise AM, Fiebiger E, Snapper SB. 134 Development of Novel Humanized Murine Models to Assess Mucosal Homeostasis: Human anti-CD3 Antibody or TNBS Administration Leads to Small and Large Bowel Inflammation Respectively in Immunodeficient Mice Transferred With Human T Cells Gastroenterology. 144. DOI: 10.1016/S0016-5085(13)60114-6  0.345
2012 Nguyen DD, Wurbel MA, Goettel JA, Eston MA, Ahmed OS, Marin R, Boden EK, Villablanca EJ, Paidassi H, Ahuja V, Reinecker HC, Fiebiger E, Lacy-Hulbert A, Horwitz BH, Mora JR, et al. Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice. Gastroenterology. 143: 719-29.e1-2. PMID 22710191 DOI: 10.1053/J.Gastro.2012.06.008  0.406
2012 Shouval D, Goettel J, Wurbel M, Horwitz B, Snapper S. IL-10 Receptor Signaling in Intestinal Innate Immune Cells is Critical for Maintaining Mucosal Homeostasis: P-237 YI Inflammatory Bowel Diseases. 18. DOI: 10.1097/00054725-201212001-00270  0.373
2012 Boden EK, Dunkin D, Goettel JA, Ahmed O, Moran CJ, Nguyen DD, Mayer L, Snapper SB. Tu1968 Increased Sensitivity to TGF Results in Defects in T Cell Proliferation and Regulatory T Cell Induction in the Absence of Wiskott-Aldrich Syndrome Protein (WASp) Gastroenterology. 142. DOI: 10.1016/S0016-5085(12)63455-6  0.308
2012 Nguyen DD, Goettel JA, Wurbel M, Ahmed O, Marin R, Horwitz B, Snapper SB. 993 WASp Deficiency in Innate Immune Cells Leads to Severe Colitis Associated With Impairment in IL-10 Production Gastroenterology. 142. DOI: 10.1016/S0016-5085(12)60658-1  0.339
2011 Hobbs SS, Goettel JA, Liang D, Yan F, Edelblum KL, Frey MR, Mullane MT, Polk DB. TNF transactivation of EGFR stimulates cytoprotective COX-2 expression in gastrointestinal epithelial cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 301: G220-9. PMID 21566012 DOI: 10.1152/Ajpgi.00383.2010  0.407
2011 Zhang Y, Li X, Carpinteiro A, Goettel JA, Soddemann M, Gulbins E. Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections. Nature Medicine. 17: 341-6. PMID 21297617 DOI: 10.1038/Nm.2296  0.312
2011 Goettel JA, Liang D, Hilliard VC, Edelblum KL, Broadus MR, Gould KL, Hanks SK, Polk DB. KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1. Experimental Cell Research. 317: 452-63. PMID 21144847 DOI: 10.1016/J.Yexcr.2010.11.018  0.566
2011 Goettel JA, Scott Algood HM, Olivares-Villagómez D, Washington MK, Chaturvedi R, Wilson KT, Van Kaer L, Polk DB. KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-γ production. Gastroenterology. 140: 265-74. PMID 20875416 DOI: 10.1053/J.Gastro.2010.09.041  0.319
2011 Nguyen DD, Goettel JA, Ahmed O, Horwitz BH, Snapper SB. Colitis in mice with WASP-Deficient myleoid cells is associated with defects in IL-10 secretion and can be rescued with exogenous IL-10P-211. Inflammatory Bowel Diseases. 17. DOI: 10.1097/00054725-201112002-00245  0.336
2011 Boden E, Goettel J, Ahmed O, Moran C, Nguyen D, Dunkin D, Mayer L, Snapper S. The Wiskott Aldrich Syndrome protein (WASp) reduces T cell proliferation and regulatory T cell induction via increased sensitivity to TGFβ: P-210. Inflammatory Bowel Diseases. 17. DOI: 10.1097/00054725-201112002-00244  0.318
2008 Edelblum KL, Goettel JA, Koyama T, McElroy SJ, Yan F, Polk DB. TNFR1 promotes tumor necrosis factor-mediated mouse colon epithelial cell survival through RAF activation of NF-kappaB. The Journal of Biological Chemistry. 283: 29485-94. PMID 18713739 DOI: 10.1074/Jbc.M801269200  0.405
2008 McElroy SJ, Frey MR, Yan F, Edelblum KL, Goettel JA, John S, Polk DB. Tumor necrosis factor inhibits ligand-stimulated EGF receptor activation through a TNF receptor 1-dependent mechanism. American Journal of Physiology. Gastrointestinal and Liver Physiology. 295: G285-93. PMID 18467504 DOI: 10.1152/Ajpgi.00425.2007  0.391
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