Leena Hilakivi-Clarke - Publications

Affiliations: 
Physiology & Biophysics Georgetown University, Washington, DC 
Area:
Nutrition, Oncology

130 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Hilakivi-Clarke L, de Oliveira Andrade F. Social Isolation and Breast Cancer. Endocrinology. 164. PMID 37586098 DOI: 10.1210/endocr/bqad126  0.379
2023 Andrade FO, Jin L, Clarke R, Wood I, Dutton M, Anjorin C, Rubin G, Gao A, Sengupta S, FitzGerald K, Hilakivi-Clarke L. Social Isolation Activates Dormant Mammary Tumors, and Modifies Inflammatory and Mitochondrial Metabolic Pathways in the Rat Mammary Gland. Cells. 12. PMID 36980301 DOI: 10.3390/cells12060961  0.302
2021 Li Y, Cook KL, Yu W, Jin L, Bouker KB, Clarke R, Hilakivi-Clarke L. Inhibition of Antiestrogen-Promoted Pro-Survival Autophagy and Tamoxifen Resistance in Breast Cancer through Vitamin D Receptor. Nutrients. 13. PMID 34069442 DOI: 10.3390/nu13051715  0.336
2021 Andrade FO, Liu F, Zhang X, Rosim MP, Dani C, Cruz I, Wang TTY, Helferich W, Li RW, Hilakivi-Clarke L. Genistein Reduces the Risk of Local Mammary Cancer Recurrence and Ameliorates Alterations in the Gut Microbiota in the Offspring of Obese Dams. Nutrients. 13. PMID 33440675 DOI: 10.3390/nu13010201  0.365
2020 Dani C, Gonçalves LK, Proença IT, Andrade FO, Hilakivi-Clarke L. Effects of Maternal Grape Juice Intake on Unfolded Protein Response in the Mammary Glands of Offspring of High Fat Diet Fed Rat Dams. Nutrients. 12. PMID 32731460 DOI: 10.3390/Nu12082253  0.488
2020 Zhang X, de Oliveira Andrade F, Zhang H, Cruz I, Clarke R, Gaur P, Verma V, Hilakivi-Clarke L. Maternal obesity increases offspring's mammary cancer recurrence and impairs tumor immune response. Endocrine-Related Cancer. PMID 32580156 DOI: 10.1530/Erc-20-0065  0.418
2019 Andrade FO, Nguyen NM, Warri A, Hilakivi-Clarke L. Reversal of increased mammary tumorigenesis by valproic acid and hydralazine in offspring of dams fed high fat diet during pregnancy. Scientific Reports. 9: 20271. PMID 31889127 DOI: 10.1038/S41598-019-56854-5  0.498
2019 Andrade FO, Yu W, Zhang X, Carney E, Hu R, Clarke R, FitzGerald K, Hilakivi-Clarke L. Effects of Jaeumkanghwa-tang on tamoxifen responsiveness in preclinical ER+ breast cancer model. Endocrine-Related Cancer. PMID 30640711 DOI: 10.1530/Erc-18-0393  0.445
2018 Fontelles CC, da Cruz RS, Hilakivi-Clarke L, de Assis S, Ong TP. Investigation of Paternal Programming of Breast Cancer Risk in Female Offspring in Rodent Models. Methods in Molecular Biology (Clifton, N.J.). 1735: 207-220. PMID 29380314 DOI: 10.1007/978-1-4939-7614-0_11  0.459
2018 Fontelles CC, da Cruz RS, Hilakivi-Clarke L, de Assis S, Ong TP. Developmental Origins of Breast Cancer: A Paternal Perspective. Methods in Molecular Biology (Clifton, N.J.). 1735: 91-103. PMID 29380308 DOI: 10.1007/978-1-4939-7614-0_5  0.431
2017 Nomura SJO, Hwang YT, Gomez SL, Fung TT, Yeh SL, Dash C, Allen L, Philips S, Hilakivi-Clarke L, Zheng YL, Wang JH. Dietary intake of soy and cruciferous vegetables and treatment-related symptoms in Chinese-American and non-Hispanic White breast cancer survivors. Breast Cancer Research and Treatment. PMID 29230660 DOI: 10.1007/S10549-017-4578-9  0.403
2017 Nguyen NM, de Oliveira Andrade F, Jin L, Zhang X, Macon M, Cruz MI, Benitez C, Wehrenberg B, Yin C, Wang X, Xuan J, de Assis S, Hilakivi-Clarke L. Maternal intake of high n-6 polyunsaturated fatty acid diet during pregnancy causes transgenerational increase in mammary cancer risk in mice. Breast Cancer Research : Bcr. 19: 77. PMID 28673325 DOI: 10.1186/S13058-017-0866-X  0.475
2017 Zhang X, Cook KL, Warri A, Cruz IM, Rosim M, Riskin J, Helferich W, Doerge D, Clarke R, Hilakivi-Clarke L. Lifetime Genistein Intake Increases the Response of Mammary Tumors to Tamoxifen in Rats. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 23: 814-824. PMID 28148690 DOI: 10.1158/1078-0432.Ccr-16-1735  0.422
2017 Shi X, Banerjee S, Chen L, Hilakivi-Clarke L, Clarke R, Xuan J. CyNetSVM: A Cytoscape App for Cancer Biomarker Identification Using Network Constrained Support Vector Machines. Plos One. 12: e0170482. PMID 28122019 DOI: 10.1371/Journal.Pone.0170482  0.353
2017 Hilakivi-Clarke L, Wärri A, Bouker KB, Zhang X, Cook KL, Jin L, Zwart A, Nguyen N, Hu R, Cruz MI, de Assis S, Wang X, Xuan J, Wang Y, Wehrenberg B, et al. Effects of In Utero Exposure to Ethinyl Estradiol on Tamoxifen Resistance and Breast Cancer Recurrence in a Preclinical Model. Journal of the National Cancer Institute. 109. PMID 27609189 DOI: 10.1093/Jnci/Djw188  0.418
2017 Clarke R, Hu R, Zhang X, Hilakivi-Clarke L, Kasid U. Abstract P4-10-02: Transmembrane protein 33 (TMEM33) induces apoptosis via UPR signaling and autophagy in breast cancer cells Cancer Research. 77. DOI: 10.1158/1538-7445.Sabcs16-P4-10-02  0.405
2017 Hu R, Zhang X, Hilakivi-Clarke L, Kasid U, Clarke R. Abstract 2329: TMEM33 induces apoptosis via UPR signaling and autophagy in breast cancer cells Cancer Research. 77: 2329-2329. DOI: 10.1158/1538-7445.Am2017-2329  0.385
2016 Cook KL, Soto-Pantoja DR, Clarke PA, Cruz MI, Zwart A, Wärri A, Hilakivi-Clarke L, Roberts DD, Clarke R. Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer. Cancer Research. 76: 5657-5670. PMID 27698188 DOI: 10.1158/0008-5472.Can-15-2616  0.372
2016 Sumis A, Cook K, Andrade FO, Hu R, Kidney E, Zhang X, Kim D, Carney E, Nguyen N, Yu W, Bouker KB, Cruz I, Clarke R, Hilakivi-Clarke L. Social isolation induces autophagy in the mouse mammary gland: link to increased mammary cancer risk. Endocrine-Related Cancer. PMID 27550962 DOI: 10.1530/Erc-16-0359  0.772
2016 Fontelles CC, Guido LN, Rosim MP, Andrade Fde O, Jin L, Inchauspe J, Pires VC, de Castro IA, Hilakivi-Clarke L, de Assis S, Ong TP. Paternal programming of breast cancer risk in daughters in a rat model: opposing effects of animal- and plant-based high-fat diets. Breast Cancer Research : Bcr. 18: 71. PMID 27456846 DOI: 10.1186/S13058-016-0729-X  0.463
2016 Fontelles CC, Carney E, Clarke J, Nguyen NM, Yin C, Jin L, Cruz MI, Ong TP, Hilakivi-Clarke L, de Assis S. Paternal overweight is associated with increased breast cancer risk in daughters in a mouse model. Scientific Reports. 6: 28602. PMID 27339599 DOI: 10.1038/Srep28602  0.458
2016 Macon M, Sumis A, Yu W, Hilakivi-Clarke L. Abstract LB-316: Social isolation alters abdominal and mammary adipocytes to potentially increase mammary tumorigenesis in mice Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-316  0.764
2016 Fontelles CC, Carney E, Clarke J, Nguyen N, Yin C, Jin L, Hilakivi-Clarke L, Ong TP, Cheng Z, Fu Y, Wang Y, Assis SMD. Abstract LB-301: Paternal overweight leads to reprogramming of daughters’ breast cancer risk in a mouse model Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-301  0.525
2016 Nguyen NM, Andrade FO, DeAssis S, Cruz I, Benitez C, Godschalk R, Hilakivi-Clarke L. Abstract 901: Transgenerational inheritance of increased mammary cancer risk in the offspring of high fat diet fed dams: Changes in oxidative stress pathways Cancer Research. 76: 901-901. DOI: 10.1158/1538-7445.Am2016-901  0.411
2016 Zhang X, Cruz I, Zhang H, Hilakivi-Clarke L. Abstract 4322: Maternal obesity increases tamoxifen resistance in female rat offspring Cancer Research. 76: 4322-4322. DOI: 10.1158/1538-7445.Am2016-4322  0.464
2016 Dani C, Neto RDB, Gonçalves LK, Frusciante M, Funchal CdS, Rosim M, Andrade F, Hilakivi-Clarke L. High Fat Diet Associated to Grape Juice Consumption during the Pregnancy Influence on the Offspring Antioxidant Profile Mediated by DNA Methilation Free Radical Biology and Medicine. 100. DOI: 10.1016/J.Freeradbiomed.2016.10.238  0.42
2015 de Oliveira Andrade F, de Assis S, Jin L, Fontelles CC, Barbisan LF, Purgatto E, Hilakivi-Clarke L, Ong TP. Lipidomic fatty acid profile and global gene expression pattern in mammary gland of rats that were exposed to lard-based high fat diet during fetal and lactation periods associated to breast cancer risk in adulthood. Chemico-Biological Interactions. PMID 26115784 DOI: 10.1016/J.Cbi.2015.06.035  0.441
2015 Liu Y, Hilakivi-Clarke L, Zhang Y, Wang X, Pan YX, Xuan J, Fleck SC, Doerge DR, Helferich WG. Isoflavones in soy flour diet have different effects on whole-genome expression patterns than purified isoflavone mix in human MCF-7 breast tumors in ovariectomized athymic nude mice. Molecular Nutrition & Food Research. PMID 25820259 DOI: 10.1002/Mnfr.201500028  0.434
2015 Hu R, Hilakivi-Clarke L, Clarke R. Molecular mechanisms of tamoxifen-associated endometrial cancer (Review). Oncology Letters. 9: 1495-1501. PMID 25788989 DOI: 10.3892/Ol.2015.2962  0.429
2015 Shi X, Barnes RO, Chen L, Shajahan-Haq AN, Hilakivi-Clarke L, Clarke R, Wang Y, Xuan J. BMRF-Net: a software tool for identification of protein interaction subnetworks by a bagging Markov random field-based method. Bioinformatics (Oxford, England). 31: 2412-4. PMID 25755273 DOI: 10.1093/Bioinformatics/Btv137  0.312
2015 Hu R, Zhang X, Hilakivi-Clarke L, Kasid U, Clarke R. Abstract P6-05-01: Endoplasmic reticulum resident protein transmembrane protein 33 (TMEM33) induces apoptosis via UPR signaling and autophagy in breast cancer cells Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P6-05-01  0.405
2015 Zhang X, Cook K, Hilakivi-Clarke L. Abstract 904: Lifetime genistein alters mammary tumors’ response to anti-estrogen tamoxifen treatment by affecting immune function in rats Cancer Research. 75: 904-904. DOI: 10.1158/1538-7445.Am2015-904  0.383
2014 Hilakivi-Clarke L. Maternal exposure to diethylstilbestrol during pregnancy and increased breast cancer risk in daughters. Breast Cancer Research : Bcr. 16: 208. PMID 25032259 DOI: 10.1186/Bcr3649  0.476
2014 de Oliveira Andrade F, Fontelles CC, Rosim MP, de Oliveira TF, de Melo Loureiro AP, Mancini-Filho J, Rogero MM, Moreno FS, de Assis S, Barbisan LF, Hilakivi-Clarke L, Ong TP. Exposure to lard-based high-fat diet during fetal and lactation periods modifies breast cancer susceptibility in adulthood in rats. The Journal of Nutritional Biochemistry. 25: 613-22. PMID 24746835 DOI: 10.1016/J.Jnutbio.2014.02.002  0.535
2014 Shajahan-Haq A, Cook K, Schwartz-Roberts J, Eltayeb A, Demas D, Warri A, Hilakivi-Clarke L, Clarke R. Glutamine metabolism and the unfolded protein response in MYC-driven breast cancer Cancer & Metabolism. 2. DOI: 10.1186/2049-3002-2-S1-P66  0.386
2014 Yin C, Cruz I, Hilakivi-Clarke L, Assis SMd. Abstract LB-244: Paternal obesity alters daughters' mammary gland development and increases markers of breast cancer risk in a mouse model Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-244  0.492
2014 Chen J, Aguilera-Barrantes I, Kuo C, Hilakivi-Clarke L, Stoner GD, Rader JS, Huang Y. Abstract 2150: Chemopreventive effects of black raspberries in endometrial cancer Cancer Research. 74: 2150-2150. DOI: 10.1158/1538-7445.Am2014-2150  0.441
2013 de Assis S, Wang M, Jin L, Bouker KB, Hilakivi-Clarke LA. Exposure to excess estradiol or leptin during pregnancy increases mammary cancer risk and prevents parity-induced protective genomic changes in rats. Cancer Prevention Research (Philadelphia, Pa.). 6: 1194-211. PMID 24169961 DOI: 10.1158/1940-6207.CAPR-13-0207  0.313
2013 Davis J, Khan G, Martin MB, Hilakivi-Clarke L. Effects of maternal dietary exposure to cadmium during pregnancy on mammary cancer risk among female offspring. Journal of Carcinogenesis. 12: 11. PMID 23858299 DOI: 10.4103/1477-3163.114219  0.413
2013 Luoto R, Mottola MF, Hilakivi-Clarke L. Pregnancy and lifestyle: short- and long-term effects on mother's and her children's health. Journal of Pregnancy. 2013: 537526. PMID 23781339 DOI: 10.1155/2013/537526  0.342
2013 Hilakivi-Clarke L, de Assis S, Warri A. Exposures to synthetic estrogens at different times during the life, and their effect on breast cancer risk. Journal of Mammary Gland Biology and Neoplasia. 18: 25-42. PMID 23392570 DOI: 10.1007/S10911-013-9274-8  0.472
2013 Shajahan AN, Cook KL, Schwartz-Roberts JL, Eltayeb AE, Demas DM, Warri A, Hilakivi-Clarke L, Metallo S, Clarke R. Abstract 5397: MYC-driven glutamine metabolism promotes antiestrogen resistance in breast cancer. Cancer Research. 73: 5397-5397. DOI: 10.1158/1538-7445.Am2013-5397  0.423
2013 Carney E, Hilakivi-Clarke L, Warri A, Assis Sd. Abstract 3700: Prepubertal dietary genistein intake reduces ovarian cancer risk in BRCA+/- mice. Cancer Research. 73: 3700-3700. DOI: 10.1158/1538-7445.Am2013-3700  0.522
2013 Andrade FO, Fontelles CC, Rosim M, Oliveira TF, Loureiro AP, Rogero MM, Moreno FS, Assis SMD, Hilakivi-Clarke L, Barbisan LF, Ong TP. Abstract 192: Exposure to high saturated fat acid diet in early life changes the susceptibility to breast cancer in adulthood. Cancer Research. 73: 192-192. DOI: 10.1158/1538-7445.Am2013-192  0.511
2013 Nguyen N, Warri A, Clarke R, Cook K, Cruz I, Assis Sd, Kim D, Lu J, Zwart A, Xuan J, Hilakivi-Clarke L. Abstract 1390: In utero estrogenic exposures increase tamoxifen resistance in a new pre-clinical model of estrogen receptor positive breast cancer. Cancer Research. 73: 1390-1390. DOI: 10.1158/1538-7445.Am2013-1390  0.474
2012 Hilakivi-Clarke L, de Assis S, Warri A, Luoto R. Pregnancy hormonal environment and mother's breast cancer risk. Hormone Molecular Biology and Clinical Investigation. 9: 11-23. PMID 25961351 DOI: 10.1515/Hmbci-2012-0019  0.474
2012 Aiyer HS, Bouker KB, Cook KL, Facey CO, Hu R, Schwartz JL, Shajahan AN, Hilakivi-Clarke L, Clarke R. Interaction of dietary polyphenols with molecular signaling pathways of antiestrogen resistance: possible role in breast cancer recurrence. Hormone Molecular Biology and Clinical Investigation. 9: 127-41. PMID 25436704 DOI: 10.1515/Hmbci-2012-0022  0.448
2012 de Assis S, Warri A, Cruz MI, Laja O, Tian Y, Zhang B, Wang Y, Huang TH, Hilakivi-Clarke L. High-fat or ethinyl-oestradiol intake during pregnancy increases mammary cancer risk in several generations of offspring. Nature Communications. 3: 1053. PMID 22968699 DOI: 10.1038/Ncomms2058  0.511
2012 Aiyer HS, Warri AM, Woode DR, Hilakivi-Clarke L, Clarke R. Influence of berry polyphenols on receptor signaling and cell-death pathways: implications for breast cancer prevention. Journal of Agricultural and Food Chemistry. 60: 5693-708. PMID 22300613 DOI: 10.1021/Jf204084F  0.406
2012 Hilakivi-Clarke L, Assis Sd, Raitanen J, Luoto R. Effects of Dietary and Physical Activity Intervention during Pregnancy on Circulating Leptin and Adiponectin Levels Food and Nutrition Sciences. 3: 556-567. DOI: 10.4236/Fns.2012.34078  0.321
2012 Zhang X, Warri A, Cruz IM, Cook K, Clarke R, Hilakivi-Clarke L. Abstract LB-167: Prepubertal or lifetime genistein intake reduces risk of tamoxifen resistance in rats Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-167  0.403
2012 Aiyer HS, Warri AM, Woode DR, Hilakivi-Clarke L, Clarke R. Abstract 580: Combined treatment of breast cancer cells with epigallocatechin gallate (EGCG) and Tamoxifen delays cell-growth in long-term culture: Implications for recurrent breast cancer Cancer Research. 72: 580-580. DOI: 10.1158/1538-7445.Am2012-580  0.4
2012 Assis Sd, Laja U, Warri A, Cruz MI, Jin L, Kim D, Hilakivi-Clarke L. Abstract 5442: MicroRNAs may mediate multigenerational epigenetic inheritance of mammary cancer risk caused by maternal exposure to high-fat diet during pregnancy Cancer Research. 72: 5442-5442. DOI: 10.1158/1538-7445.Am2012-5442  0.403
2011 de Assis S, Warri A, Benitez C, Helferich W, Hilakivi-Clarke L. Protective effects of prepubertal genistein exposure on mammary tumorigenesis are dependent on BRCA1 expression. Cancer Prevention Research (Philadelphia, Pa.). 4: 1436-48. PMID 21680703 DOI: 10.1158/1940-6207.Capr-10-0346  0.378
2011 Nielsen TS, Purup S, Wärri A, Godschalk RW, Hilakivi-Clarke L. Effects of maternal exposure to cow's milk high or low in isoflavones on carcinogen-induced mammary tumorigenesis among rat offspring. Cancer Prevention Research (Philadelphia, Pa.). 4: 694-701. PMID 21467133 DOI: 10.1158/1940-6207.Capr-10-0220  0.448
2011 Nielsen TS, Khan G, Davis J, Michels KB, Hilakivi-Clarke L. Prepubertal exposure to cow's milk reduces susceptibility to carcinogen-induced mammary tumorigenesis in rats. International Journal of Cancer. 128: 12-20. PMID 20232392 DOI: 10.1002/Ijc.25313  0.408
2011 Sumis AM, Kim DC, Hilakivi-Clarke L. Abstract 1811: Social isolation stress-induced obesity increases mammary cancer risk Cancer Research. 71: 1811-1811. DOI: 10.1158/1538-7445.Am2011-1811  0.764
2010 Shajahan AN, Goel S, de Assis S, Yu B, Clarke R, Hilakivi-Clarke L. Changes in mammary caveolin-1 signaling pathways are associated with breast cancer risk in rats exposed to estradiol in utero or during prepuberty. Hormone Molecular Biology and Clinical Investigation. 2: 227-234. PMID 23805170 DOI: 10.1515/Hmbci.2010.031  0.433
2010 Hilakivi-Clarke L, Andrade JE, Helferich W. Is soy consumption good or bad for the breast? The Journal of Nutrition. 140: 2326S-2334S. PMID 20980638 DOI: 10.3945/Jn.110.124230  0.387
2010 de Assis S, Warri A, Cruz MI, Hilakivi-Clarke L. Changes in mammary gland morphology and breast cancer risk in rats. Journal of Visualized Experiments : Jove. PMID 20972418 DOI: 10.3791/2260  0.484
2010 Yu W, Cline M, Maxwell LG, Berrigan D, Rodriguez G, Warri A, Hilakivi-Clarke L. Dietary vitamin D exposure prevents obesity-induced increase in endometrial cancer in Pten+/- mice. Cancer Prevention Research (Philadelphia, Pa.). 3: 1246-58. PMID 20858763 DOI: 10.1158/1940-6207.Capr-10-0088  0.468
2010 Vissapragada S, Ghosh A, Ringer L, Salinas P, Brophy A, Peaceman D, Kallakury B, Banerjee PP, Fricke ST, Helfrich W, Lee YC, Pestell R, Scherer P, Tanowitz HB, Avantaggiati ML, ... Hilakivi-Clarke L, et al. Dietary n-3 polyunsaturated fatty acids fail to reduce prostate tumorigenesis in the PB-ErbB-2 x Pten(+/-) preclinical mouse model. Cell Cycle (Georgetown, Tex.). 9: 1824-9. PMID 20404514 DOI: 10.4161/Cc.9.9.11542  0.403
2010 Assis Sd, Cruz MI, Warri A, Hilakivi-Clarke L. Abstract 2931: Exposure of rat dams to a high-fat or estradiol-supplemented diet during pregnancy alters mammary gland morphology and increases mammary cancer risk in their daughters and granddaughters Cancer Research. 70: 2931-2931. DOI: 10.1158/1538-7445.Am10-2931  0.48
2010 Yu W, Maxwell LG, Cline M, Berrigan D, Rodriguez G, Warri A, Hilakivi-Clarke L. Abstract 2888: Vitamin D inhibits obesity-induced endometrial carcinogenesis inPten+/−mice Cancer Research. 70: 2888-2888. DOI: 10.1158/1538-7445.Am10-2888  0.483
2009 Messina M, Hilakivi-Clarke L. Early intake appears to be the key to the proposed protective effects of soy intake against breast cancer. Nutrition and Cancer. 61: 792-8. PMID 20155618 DOI: 10.1080/01635580903285015  0.473
2009 Lof M, Hilakivi-Clarke L, Sandin S S, de Assis S, Yu W, Weiderpass E. Dietary fat intake and gestational weight gain in relation to estradiol and progesterone plasma levels during pregnancy: a longitudinal study in Swedish women. Bmc Women's Health. 9: 10. PMID 19402915 DOI: 10.1186/1472-6874-9-10  0.407
2009 Wang M, Yu B, Westerlind K, Strange R, Khan G, Patil D, Boeneman K, Hilakivi-Clarke L. Prepubertal physical activity up-regulates estrogen receptor β, BRCA1 and p53 mRNA expression in the rat mammary gland Breast Cancer Research and Treatment. 115: 213-220. PMID 18516675 DOI: 10.1007/S10549-008-0062-X  0.376
2008 Olivo-Marston SE, Zhu Y, Lee RY, Cabanes A, Khan G, Zwart A, Wang Y, Clarke R, Hilakivi-Clarke L. Gene signaling pathways mediating the opposite effects of prepubertal low-fat and high-fat n-3 polyunsaturated fatty acid diets on mammary cancer risk. Cancer Prevention Research (Philadelphia, Pa.). 1: 532-45. PMID 19139003 DOI: 10.1158/1940-6207.Capr-08-0030  0.406
2008 Xue F, Hilakivi-Clarke LA, Maxwell GL, Hankinson SE, Michels KB. Infant feeding and the incidence of endometrial cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 17: 1316-21. PMID 18541614 DOI: 10.1158/1055-9965.EPI-08-0108  0.35
2008 Löf M, Hilakivi-Clarke L, Sandin S, Weiderpass E. Effects of pre-pregnancy physical activity and maternal BMI on gestational weight gain and birth weight. Acta Obstetricia Et Gynecologica Scandinavica. 87: 524-30. PMID 18446535 DOI: 10.1080/00016340802012288  0.301
2008 Warri A, Saarinen NM, Makela S, Hilakivi-Clarke L. The role of early life genistein exposures in modifying breast cancer risk British Journal of Cancer. 98: 1485-1493. PMID 18392054 DOI: 10.1038/Sj.Bjc.6604321  0.444
2007 Löf M, Sandin S, Lagiou P, Hilakivi-Clarke L, Trichopoulos D, Adami HO, Weiderpass E. Dietary fat and breast cancer risk in the Swedish women's lifestyle and health cohort British Journal of Cancer. 97: 1570-1576. PMID 17940510 DOI: 10.1038/Sj.Bjc.6604033  0.469
2007 Hilakivi-Clarke L. Nutritional modulation of terminal end buds: its relevance to breast cancer prevention. Current Cancer Drug Targets. 7: 465-74. PMID 17691906 DOI: 10.2174/156800907781386641  0.473
2007 Khan G, Penttinen P, Cabanes A, Foxworth A, Chezek A, Mastropole K, Yu B, Smeds A, Halttunen T, Good C, Mäkelä S, Hilakivi-Clarke L. Maternal flaxseed diet during pregnancy or lactation increases female rat offspring's susceptibility to carcinogen-induced mammary tumorigenesis. Reproductive Toxicology (Elmsford, N.Y.). 23: 397-406. PMID 17398067 DOI: 10.1016/J.Reprotox.2007.02.002  0.494
2007 Kinnunen TI, Pasanen M, Aittasalo M, Fogelholm M, Hilakivi-Clarke L, Weiderpass E, Luoto R. Preventing excessive weight gain during pregnancy - A controlled trial in primary health care European Journal of Clinical Nutrition. 61: 884-891. PMID 17228348 DOI: 10.1038/Sj.Ejcn.1602602  0.332
2007 Löf M, Sandin S, Hilakivi-Clarke L, Weiderpass E. Birth weight in relation to endometrial and breast cancer risks in Swedish women British Journal of Cancer. 96: 134-136. PMID 17146473 DOI: 10.1038/Sj.Bjc.6603504  0.418
2006 De Assis S, Hilakivi-Clarke L. Timing of dietary estrogenic exposures and breast cancer risk. Annals of the New York Academy of Sciences. 1089: 14-35. PMID 17261753 DOI: 10.1196/annals.1386.039  0.439
2006 Hilakivi-Clarke L, de Assis S. Fetal origins of breast cancer. Trends in Endocrinology and Metabolism: Tem. 17: 340-8. PMID 16997567 DOI: 10.1016/J.Tem.2006.09.002  0.484
2006 Hilakivi-Clarke L, Shajahan A, Yu B, de Assis S. Differentiation of mammary gland as a mechanism to reduce breast cancer risk. The Journal of Nutrition. 136: 2697S-9S. PMID 16988155 DOI: 10.1093/Jn/136.10.2697S  0.484
2006 Yu B, Khan G, Foxworth A, Huang K, Hilakivi-Clarke L. Maternal dietary exposure to fiber during pregnancy and mammary tumorigenesis among rat offspring. International Journal of Cancer. 119: 2279-86. PMID 16921499 DOI: 10.1002/Ijc.22201  0.502
2006 de Assis S, Khan G, Hilakivi-Clarke L. High birth weight increases mammary tumorigenesis in rats. International Journal of Cancer. 119: 1537-46. PMID 16646052 DOI: 10.1002/Ijc.21936  0.449
2006 Trock BJ, Hilakivi-Clarke L, Clarke R. Meta-analysis of soy intake and breast cancer risk. Journal of the National Cancer Institute. 98: 459-71. PMID 16595782 DOI: 10.1093/Jnci/Djj102  0.449
2006 de Assis S, Wang M, Goel S, Foxworth A, Helferich W, Hilakivi-Clarke L. Excessive weight gain during pregnancy increases carcinogen-induced mammary tumorigenesis in Sprague-Dawley and lean and obese Zucker rats. The Journal of Nutrition. 136: 998-1004. PMID 16549464 DOI: 10.1093/Jn/136.4.998  0.402
2005 Hilakivi-Clarke L, Luoto R, Huttunen T, Koskenvuo M. Pregnancy weight gain and premenopausal breast cancer risk. The Journal of Reproductive Medicine. 50: 811-6. PMID 16419626  0.343
2005 Hilakivi-Clarke L, Olivo SE, Shajahan A, Khan G, Zhu Y, Zwart A, Cho E, Clarke R. Mechanisms mediating the effects of prepubertal (n-3) polyunsaturated fatty acid diet on breast cancer risk in rats. The Journal of Nutrition. 135: 2946S-2952S. PMID 16317153 DOI: 10.1093/Jn/135.12.2946S  0.42
2005 Olivo SE, Hilakivi-Clarke L. Opposing effects of prepubertal low- and high-fat n-3 polyunsaturated fatty acid diets on rat mammary tumorigenesis. Carcinogenesis. 26: 1563-72. PMID 15888492 DOI: 10.1093/Carcin/Bgi118  0.438
2004 Hilakivi-Clarke L, Wang C, Kalil M, Riggins R, Pestell RG. Nutritional modulation of the cell cycle and breast cancer Endocrine-Related Cancer. 11: 603-622. PMID 15613442 DOI: 10.1677/Erc.1.00665  0.437
2004 Kinnunen TI, Luoto R, Gissler M, Hemminki E, Hilakivi-Clarke L. Pregnancy weight gain and breast cancer risk. Bmc Women's Health. 4: 7. PMID 15498103 DOI: 10.1186/1472-6874-4-7  0.463
2004 Hilakivi-Clarke L, Cabanes A, De Assis S, Wang M, Khan G, Shoemaker WJ, Stevens RG. In utero alcohol exposure increases mammary tumorigenesis in rats British Journal of Cancer. 90: 2225-2231. PMID 15150620 DOI: 10.1038/Sj.Bjc.6601793  0.368
2004 Cabanes A, Wang M, Olivo S, DeAssis S, Gustafsson JA, Khan G, Hilakivi-Clarke L. Prepubertal estradiol and genistein exposures up-regulate BRCA1 mRNA and reduce mammary tumorigenesis. Carcinogenesis. 25: 741-8. PMID 14729590 DOI: 10.1093/Carcin/Bgh065  0.412
2003 Johnson MD, Kenney N, Stoica A, Hilakivi-Clarke L, Singh B, Chepko G, Clarke R, Sholler PF, Lirio AA, Foss C, Reiter R, Trock B, Paik S, Martin MB. Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland. Nature Medicine. 9: 1081-4. PMID 12858169 DOI: 10.1038/Nm902  0.417
2002 Block KI, Constantinou A, Hilakivi-Clarke L, Hughes C, Tripathy D, Tice JA. Point-counterpoint: soy intake for breast cancer patients. Integrative Cancer Therapies. 1: 90-100. PMID 14664752 DOI: 10.1177/153473540200100119  0.415
2002 Hilakivi-Clarke L, Cho E, Cabanes A, DeAssis S, Olivo S, Helferich W, Lippman ME, Clarke R. Dietary modulation of pregnancy estrogen levels and breast cancer risk among female rat offspring. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 3601-10. PMID 12429652  0.398
2002 Hilakivi-Clarke L, Cabanes A, Olivo S, Kerr L, Bouker KB, Clarke R. Do estrogens always increase breast cancer risk? Journal of Steroid Biochemistry and Molecular Biology. 80: 163-174. PMID 11897501 DOI: 10.1016/S0960-0760(01)00184-4  0.456
2001 Hilakivi-Clarke L, Forsén T, Eriksson JG, Luoto R, Tuomilehto J, Osmond C, Barker DJ. Tallness and overweight during childhood have opposing effects on breast cancer risk. British Journal of Cancer. 85: 1680-4. PMID 11742488 DOI: 10.1054/Bjoc.2001.2109  0.447
2001 Stevens RG, Hilakivi-Clarke L. Alcohol exposure in utero and breast cancer risk later in life Alcohol and Alcoholism. 36: 276-277. PMID 11373268 DOI: 10.1093/Alcalc/36.3.276  0.308
2001 Hilakivi-Clarke L, Cho E, deAssis S, Olivo S, Ealley E, Bouker KB, Welch JN, Khan G, Clarke R, Cabanes A. Maternal and prepubertal diet, mammary development and breast cancer risk. The Journal of Nutrition. 131: 154S-157S. PMID 11208953 DOI: 10.1093/Jn/131.1.154S  0.497
2001 Clarke R, Hilakivi-Clarke L, Trock B. Breast cancer: Dietary and environmental oestrogens Biologist. 48: 21-26. PMID 11178620  0.34
2000 Cabanes A, De Assis S, Gustafsson JA, Hilakivi-Clarke L. Maternal high n-6 polyunsaturated fatty acid intake during pregnancy increases voluntary alcohol intake and hypothalamic estrogen receptor alpha and beta levels among female offspring Developmental Neuroscience. 22: 488-493. PMID 11111167 DOI: 10.1159/000017480  0.364
2000 Hilakivi-Clarke L. Estrogens, BRCA1, and breast cancer Cancer Research. 60: 4993-5001. PMID 11016617  0.34
2000 Bouker KB, Hilakivi-Clarke L. Genistein: Does it prevent or promote breast cancer? Environmental Health Perspectives. 108: 701-708. PMID 10964789 DOI: 10.1289/Ehp.00108701  0.47
2000 Hilakivi-Clarke L, Cho E, Onojafe I, Liao DJ, Clarke R. Maternal exposure to tamoxifen during pregnancy increases carcinogen- induced mammary tumorigenesis among female rat offspring Clinical Cancer Research. 6: 305-308. PMID 10656462  0.37
1999 Hilakivi-Clarke L, Onojafe I, Raygada M, Cho E, Skaar T, Russo I, Clarke R. Prepubertal exposure to zearalenone or genistein reduces mammary tumorigenesis British Journal of Cancer. 80: 1682-1688. PMID 10468283 DOI: 10.1038/Sj.Bjc.6690584  0.403
1999 Hilakivi-Clarke L, Cho E, Onojafe I, Raygada M, Clarke R. Maternal exposure to genistein during pregnancy increases carcinogen-induced mammary tumorigenesis in female rat offspring Oncology Reports. 6: 1089-1095. PMID 10425307 DOI: 10.3892/Or.6.5.1089  0.462
1999 Hilakivi-Clarke L, Clarke R, Lippman M. The influence of maternal diet on breast cancer risk among female offspring. Nutrition (Burbank, Los Angeles County, Calif.). 15: 392-401. PMID 10355854 DOI: 10.1016/S0899-9007(99)00029-5  0.542
1998 Yenbutr P, Hilakivi-Clarke L, Passaniti A. Hypomethylation of an exon I estrogen receptor CpG island in spontaneous and carcinogen induced mammary tumorigenesis in the rat Mechanisms of Ageing and Development. 106: 93-102. PMID 9883975 DOI: 10.1016/S0047-6374(98)00093-1  0.417
1998 Raygada M, Cho E, Hilakivi-Clarke L. High maternal intake of polyunsaturated fatty acids during pregnancy in mice alters offsprings' aggressive behavior, immobility in the swim test, locomotor activity and brain protein kinase C activity Journal of Nutrition. 128: 2505-2511. PMID 9868200 DOI: 10.1093/Jn/128.12.2505  0.394
1998 Hilakivi-Clarke L, Clarke R. Timing of dietary fat exposure and mammary tumorigenesis: Role of estrogen receptor and protein kinase C activity Molecular and Cellular Biochemistry. 188: 5-12. PMID 9823005 DOI: 10.1023/A:1006827229431  0.535
1998 Hilakivi-Clarke L, Cho E, Clarke R. Maternal genistein exposure mimics the effects of estrogen on mammary gland development in female mouse offspring Oncology Reports. 5: 609-616. PMID 9538161 DOI: 10.3892/Or.5.3.609  0.427
1998 Hilakivi-Clarke L, Stoica A, Raygada M, Martin M. Consumption of a high-fat diet alters estrogen receptor content, protein kinase C activity, and mammary gland morphology in virgin and pregnant mice and female offspring Cancer Research. 58: 654-660. PMID 9485017  0.362
1997 Hilakivi-Clarke L. Mechanisms by which high maternal fat intake during pregnancy increases breast cancer risk in female rodent offspring Breast Cancer Research and Treatment. 46: 199-214. PMID 9478275 DOI: 10.1023/A:1005983621612  0.516
1997 Hilakivi-Clarke L. Estrogen-regulated non-reproductive behaviors and breast cancer risk: Animal models and human studies Breast Cancer Research and Treatment. 46: 143-159. PMID 9478270 DOI: 10.1023/A:1005964511134  0.451
1997 Hilakivi-Clarke L, Clarke R, Onojafe I, Raygada M, Cho E, Lippman M. A maternal diet high in n - 6 polyunsaturated fats alters mammary gland development, puberty onset, and breast cancer risk among female rat offspring Proceedings of the National Academy of Sciences of the United States of America. 94: 9372-9377. PMID 9256489 DOI: 10.1073/Pnas.94.17.9372  0.505
1997 Hilakivi-Clarke L. Maternal handling during pregnancy reduces DMBA-induced mammary tumorigenesis among female offspring British Journal of Cancer. 76: 150-155. PMID 9231913 DOI: 10.1038/Bjc.1997.356  0.36
1997 Hilakivi-Clarke L, Cho E, Raygada M. Early postnatal treatment with transforming growth factor α does not alter nonreproductive behavior Physiology and Behavior. 62: 207-211. PMID 9226364 DOI: 10.1016/S0031-9384(97)00160-1  0.312
1997 Cohen LA, Hilakivi-Clarke L. Re: Breast cancer risk in rats fed a diet high in n-6 polyunsaturated fatty acids during pregnancy [5] Journal of the National Cancer Institute. 89: 662-663. PMID 9150196  0.368
1997 Hilakivi-Clarke L, Cho E, Raygada M, Kenney N. Alterations in mammary gland development following neonatal exposure to estradiol, transforming growth factor α, and estrogen receptor antagonist ICI 182,780 Journal of Cellular Physiology. 170: 279-289. PMID 9066785 DOI: 10.1002/(Sici)1097-4652(199703)170:3<279::Aid-Jcp9>3.0.Co;2-L  0.354
1996 Hilakivi-Clarke L, Onojafe I, Raygada M, Cho E, Clarke R, Lippman ME. Breast cancer risk in rats fed a diet high in n-6 polyunsaturated fatty acids during pregnancy Journal of the National Cancer Institute. 88: 1821-1827. PMID 8961971 DOI: 10.1093/Jnci/88.24.1821  0.494
1996 Clarke R, Hilakivi-Clarke L, Cho E, James MR, Leonessa F. Estrogens, phytoestrogens, and breast cancer Advances in Experimental Medicine and Biology. 401: 63-85. PMID 8886127 DOI: 10.1007/978-1-4613-0399-2_6  0.429
1996 Hilakivi-Clarke L, Cho E, Onojafe I. High-fat diet induces aggressive behavior in male mice and rats Life Sciences. 58: 1653-1660. PMID 8632702 DOI: 10.1016/0024-3205(96)00140-3  0.418
1995 Hilakivi-Clarke L, Cho E, Raygada M, Onojafe I, Clarke R, Lippman ME. Early life affects the risk of developing breast cancer Annals of the New York Academy of Sciences. 768: 327-330. PMID 8526379 DOI: 10.1111/J.1749-6632.1995.Tb12152.X  0.414
1995 Hilakivi-Clarke L, Goldberg R. Gonadal hormones and aggression-maintaining effect of alcohol in male transgenic transforming growth factor-α mice Alcoholism: Clinical and Experimental Research. 19: 708-713. PMID 7573797 DOI: 10.1111/J.1530-0277.1995.Tb01571.X  0.342
1995 Hilakivi-Clarke L, Dickson RB. Stress influence on development of hepatocellular tumors in transgenic mice overexpressing tgfet Acta Oncologica. 34: 907-912. PMID 7492379 DOI: 10.3109/02841869509127203  0.385
1994 Hilakivi-Clarke L. Overexpression of transforming growth factor α in transgenic mice alters nonreproductive, sex-related behavioral differences: Interaction with gonadal hormones Behavioral Neuroscience. 108: 410-417. PMID 8037884 DOI: 10.1037//0735-7044.108.2.410  0.346
1994 Hilakivi-Clarke L, Rowland J, Clarke R, Lippman ME. Psychosocial factors in the development and progression of breast cancer Breast Cancer Research and Treatment. 29: 141-160. PMID 8012033 DOI: 10.1007/Bf00665676  0.445
1994 Hilakivi-Clarke L, Clarke R, Lippman ME. Perinatal factors increase breast cancer risk Breast Cancer Research and Treatment. 31: 273-284. PMID 7881105 DOI: 10.1007/Bf00666160  0.538
1993 Hilakivi-Clarke LA, Arora PK, Clarke R, Wright A, Lippman ME, Dickson RB. Opposing behavioural alterations in male and female transgenic tgfα mice: Association with tumour susceptibility British Journal of Cancer. 67: 1026-1030. PMID 8494695 DOI: 10.1038/Bjc.1993.188  0.33
1993 Hilakivi-Clarke L, Durcan M, Goldberg R. Effect of alcohol on elevated aggressive behavior in male transgenic TGFα mice Neuroreport. 4: 155-158. PMID 8453053 DOI: 10.1097/00001756-199302000-00010  0.323
1993 Hilakivi-Clarke L, Wright A, Lippman ME. DMBA-induced mammary tumor growth in rats exhibiting increased or decreased ability to cope with stress due to early postnatal handling or antidepressant treatment Physiology and Behavior. 54: 229-236. PMID 8372115 DOI: 10.1016/0031-9384(93)90104-N  0.35
1992 Hilakivi-Clarke L, Lister RG. Social status and voluntary alcohol consumption in mice: interaction with stress. Psychopharmacology. 108: 276-82. PMID 1523279 DOI: 10.1007/Bf02245112  0.315
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