| Year |
Citation |
Score |
| 2024 |
Su Y, Carter JL, Li X, Fukuda Y, Gray A, Lynch J, Edwards H, Ma J, Schreiner P, Polin L, Kushner J, Dzinic SH, Buck SA, Pruett-Miller SM, Hurrish KH, ... ... Schimmer AD, et al. The imipridone ONC213 targets α-ketoglutarate dehydrogenase to induce mitochondrial stress and suppress oxidative phosphorylation in acute myeloid leukemia. Cancer Research. PMID 38266099 DOI: 10.1158/0008-5472.CAN-23-2659 |
0.381 |
|
| 2023 |
Akiyama H, Zhao R, Ostermann LB, Li Z, Tcheng M, Yazdani SJ, Moayed A, Pryor ML, Slngh S, Baran N, Ayoub E, Nishida Y, Mak PY, Ruvolo VR, Carter BZ, ... Schimmer AD, et al. Mitochondrial regulation of GPX4 inhibition-mediated ferroptosis in acute myeloid leukemia. Leukemia. PMID 38148395 DOI: 10.1038/s41375-023-02117-2 |
0.404 |
|
| 2022 |
Fazzari F, Chow S, Cheung M, Barghout SH, Schimmer AD, Chang Q, Hedley D. Combined Targeting of the Glutathione and Thioredoxin Antioxidant Systems in Pancreatic Cancer. Acs Pharmacology & Translational Science. 5: 1070-1078. PMID 36407947 DOI: 10.1021/acsptsci.2c00170 |
0.322 |
|
| 2021 |
Lee JB, Khan DH, Hurren R, Xu M, Na Y, Kang H, Mirali S, Wang X, Gronda M, Jitkova Y, MacLean N, Arruda A, Alaniz Z, Konopleva MY, Andreeff M, ... ... Schimmer AD, et al. Venetoclax enhances T cell-mediated antileukemic activity by increasing ROS production. Blood. 138: 234-245. PMID 34292323 DOI: 10.1182/blood.2020009081 |
0.387 |
|
| 2021 |
Feng Y, Nouri K, Schimmer AD. Mitochondrial ATP-Dependent Proteases-Biological Function and Potential Anti-Cancer Targets. Cancers. 13. PMID 33922062 DOI: 10.3390/cancers13092020 |
0.331 |
|
| 2021 |
Lee J, Khan DH, Hurren R, Xu M, Na Y, Kang H, Mirali S, Wang X, Gronda MV, Jitkova Y, MacLean N, Arruda A, Alaniz Z, Konopleva MY, Andreeff M, ... ... Schimmer AD, et al. Venetoclax enhances T cell-mediated anti-leukemic activity by increasing ROS production. Blood. PMID 33728465 DOI: 10.1182/blood.2020009081 |
0.391 |
|
| 2021 |
Tcheng M, Roma A, Ahmed N, Smith RW, Jayanth P, Minden MD, Schimmer AD, Hess DA, Hope K, Akhtar T, Bohrnsen E, D'Alessandro A, Mohsen AW, Vockley J, Spagnuolo PA. Very long chain fatty acid metabolism is required in acute myeloid leukemia. Blood. PMID 33720355 DOI: 10.1182/blood.2020008551 |
0.365 |
|
| 2021 |
Barghout SH, Aman A, Nouri K, Blatman Z, Arevalo K, Thomas GE, MacLean N, Hurren R, Ketela T, Saini M, Abohawya M, Kiyota T, Al-Awar R, Schimmer AD. A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity. Jci Insight. PMID 33476303 DOI: 10.1172/jci.insight.141518 |
0.334 |
|
| 2020 |
Schimmer AD, Singh RP, Seneviratne AK, Thomas GE, MacLean N, Hurren R. Transduction of Primary AML Cells with Lentiviral Vector for Study or Engraftment. Star Protocols. 1: 100163. PMID 33377057 DOI: 10.1016/j.xpro.2020.100163 |
0.306 |
|
| 2020 |
Nouri K, Feng Y, Schimmer AD. Mitochondrial ClpP serine protease-biological function and emerging target for cancer therapy. Cell Death & Disease. 11: 841. PMID 33037181 DOI: 10.1038/s41419-020-03062-z |
0.307 |
|
| 2020 |
Mirali S, Schimmer AD. Targeting neurolysin in acute myeloid leukemia. Molecular & Cellular Oncology. 7: 1761243. PMID 32944624 DOI: 10.1080/23723556.2020.1761243 |
0.32 |
|
| 2020 |
Mirali S, Schimmer AD. The role of mitochondrial proteases in leukemic cells and leukemic stem cells. Stem Cells Translational Medicine. PMID 32761807 DOI: 10.1002/sctm.20-0142 |
0.304 |
|
| 2020 |
Longo J, Pandyra AA, Stachura P, Minden MD, Schimmer AD, Penn LZ. Cyclic AMP-hydrolyzing phosphodiesterase inhibitors potentiate statin-induced cancer cell death. Molecular Oncology. PMID 32749766 DOI: 10.1002/1878-0261.12775 |
0.37 |
|
| 2020 |
Singh RP, Jeyaraju DV, Voisin V, Hurren R, Xu C, Hawley JR, Barghout SH, Khan DH, Gronda M, Wang X, Jitkova Y, Sharon D, Liyanagae S, MacLean N, Seneviratene AK, ... ... Schimmer AD, et al. Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal. Cell Stem Cell. PMID 32416059 DOI: 10.1016/J.Stem.2020.04.010 |
0.323 |
|
| 2020 |
Khan DH, Mullokandov M, Wu Y, Voisin V, Gronda MV, Hurren R, Wang X, MacLean N, Jeyaraju DV, Jitkova Y, Xu GW, Laister RC, Seneviratne A, Blatman Z, Ketala T, ... ... Schimmer AD, et al. Mitochondrial carrier homolog 2 (MTCH2) is necessary for AML survival. Blood. PMID 32299104 DOI: 10.1182/Blood.2019000106 |
0.368 |
|
| 2020 |
Mirali S, Botham A, Voisin V, Xu C, St-Germain J, Sharon D, Hoff FW, Qiu Y, Hurren R, Gronda M, Jitkova Y, Nachmias B, MacLean N, Wang X, Arruda A, ... ... Schimmer AD, et al. The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability. Science Translational Medicine. 12. PMID 32269163 DOI: 10.1126/Scitranslmed.Aaz8264 |
0.389 |
|
| 2019 |
Sharon D, Cathelin S, Mirali S, Di Trani JM, Yanofsky DJ, Keon KA, Rubinstein JL, Schimmer AD, Ketela T, Chan SM. Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response. Science Translational Medicine. 11. PMID 31666400 DOI: 10.1126/Scitranslmed.Aax2863 |
0.361 |
|
| 2019 |
Botham A, Coyaud E, Nirmalanandhan VS, Gronda M, Hurren R, Maclean N, St-Germain J, Mirali S, Laurent E, Raught B, Schimmer A. Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2. Proteomics. e1900139. PMID 31617661 DOI: 10.1002/Pmic.201900139 |
0.346 |
|
| 2019 |
Dai S, Yang S, Hu X, Sun W, Tawa G, Zhu W, Schimmer AD, He C, Fang B, Zhu H, Zheng W. 17-hydroxy wortmannin restores TRAIL's response by ameliorating increased beclin 1 level and autophagy function in TRAIL-resistant colon cancer cells. Molecular Cancer Therapeutics. PMID 31092562 DOI: 10.1158/1535-7163.Mct-18-1241 |
0.336 |
|
| 2019 |
Ishizawa J, Zarabi SF, Davis RE, Halgas O, Nii T, Jitkova Y, Zhao R, St-Germain J, Heese LE, Egan G, Ruvolo VR, Barghout SH, Nishida Y, Hurren R, Ma W, ... ... Schimmer AD, et al. Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality. Cancer Cell. PMID 31056398 DOI: 10.1016/J.Ccell.2019.03.014 |
0.329 |
|
| 2019 |
Seneviratne AK, Xu M, Henao JJA, Fajardo VA, Hao Z, Voisin V, Xu GW, Hurren R, Kim S, MacLean N, Wang X, Gronda M, Jeyaraju D, Jitkova Y, Ketela T, ... ... Schimmer AD, et al. The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids. Cell Stem Cell. PMID 30930145 DOI: 10.1016/J.Stem.2019.02.020 |
0.304 |
|
| 2019 |
Hu D, Sun X, Liao X, Zhang X, Zarabi S, Schimmer A, Hong Y, Ford C, Luo Y, Qi X. Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity. Acta Neuropathologica. PMID 30877431 DOI: 10.1007/S00401-019-01993-2 |
0.358 |
|
| 2019 |
Zhao R, Zarabi S, Nii T, Halgas O, Jitkova Y, Ruvolo V, Heese L, Nishida Y, Borthakur GM, Kojima K, Stogniew M, Oster W, Pai E, Davis E, Kantarjian HM, ... Schimmer AD, et al. Dual Targeting of Mitochondrial Unfolded Protein Response and BCL2 in Acute Myeloid Leukemia Blood. 134: 2562-2562. DOI: 10.1182/Blood-2019-127101 |
0.3 |
|
| 2019 |
Mirali S, Aaron B, Voisin V, Xu C, St-Germain J, Sharon D, Hoff FW, Qiu Y, Hurren R, Gronda M, Jitkova Y, Xu GW, Nachmias B, MacLean N, Wang X, ... ... Schimmer AD, et al. The Mitochondrial Protease, Neurolysin (NLN), Regulates Respiratory Chain Complex and Supercomplex Formation and Is Necessary for AML Viability Blood. 134: 729-729. DOI: 10.1182/Blood-2019-122784 |
0.453 |
|
| 2019 |
Nachmias B, Voisin V, Hurren R, Wang X, Maclean N, Xu GW, Seneviratne AK, Xu C, Bader GD, Shlush LI, Schimmer AD. IPO11 Is Upregulated in Relapsed AML and Supports Survival of Leukemic Stem Cells Blood. 134: 2530-2530. DOI: 10.1182/blood-2019-122284 |
0.355 |
|
| 2019 |
Tcheng M, Roma A, Ahmed N, Smith R, Jayanth P, Minden MD, Hurren R, Schimmer AD, Bozzo G, Hess D, Hope K, Rea K, Akhtar TA, Mohsen A, Vockley J, et al. Inhibiting Very Long Chain Acyl-CoA Dehydrogenase (VLCAD) Induces Selective Leukemia Cell Death Blood. 134: 3922-3922. DOI: 10.1182/Blood-2019-122262 |
0.426 |
|
| 2019 |
Botham AD, Coyaud E, Nirmalanandhan S, Gronda M, Hurren R, Maclean N, Germain JS, Mirali S, Laurent E, Raught B, Schimmer A. Abstract 4529: Mapping the protein interactome of mitochondrial intermembrane space proteases identifies a novel function for HTRA2 Cancer Research. 79: 4529-4529. DOI: 10.1158/1538-7445.Sabcs18-4529 |
0.429 |
|
| 2019 |
Andrews C, Atenafu EG, Murphy T, Al-Shaibani Z, Chan SM, Gupta V, Kim DDH, Kumar R, Lam W, Lipton JH, Mattsson J, Maze D, Michelis F, McNamara CJ, Schimmer AD, et al. Allogeneic Stem Cell Transplantation Has Limited Benefit in Older Patients with Mixed Phenotype Acute Leukemia Blood. 134: 5725-5725. DOI: 10.1016/J.Bbmt.2019.12.642 |
0.302 |
|
| 2018 |
Yehudai D, Liyanage SU, Hurren R, Rizoska B, Albertella M, Gronda M, Jeyaraju DV, Wang X, Barghout SH, MacLean N, Siriwardena TP, Jitkova Y, Targett-Adams P, Schimmer AD. The thymidine dideoxynucleoside analogue, alovudine, inhibits the mitochondrial DNA polymerase γ, impairs oxidative phosphorylation and promotes monocytic differentiation in acute myeloid leukemia. Haematologica. PMID 30573504 DOI: 10.3324/haematol.2018.195172 |
0.331 |
|
| 2018 |
Khoury H, He R, Schimmer A, Beadle JR, Hostetler KY, Minden MD. Octadecyloxyethyl Adefovir Exhibits Potent in vitro and in vivo Cytotoxic Activity and Has Synergistic Effects with Ara-C in Acute Myeloid Leukemia. Chemotherapy. 63: 225-237. PMID 30372692 DOI: 10.1159/000491705 |
0.494 |
|
| 2018 |
Wong KS, Mabanglo MF, Seraphim TV, Mollica A, Mao YQ, Rizzolo K, Leung E, Moutaoufik MT, Hoell L, Phanse S, Goodreid J, Barbosa LRS, Ramos CHI, Babu M, Mennella V, ... ... Schimmer AD, et al. Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death. Cell Chemical Biology. 25: 1017-1030.e9. PMID 30126533 DOI: 10.1016/J.Chembiol.2018.05.014 |
0.357 |
|
| 2018 |
Barghout SH, Patel PS, Wang X, Xu GW, Kavanagh S, Halgas O, Zarabi SF, Gronda M, Hurren R, Jeyaraju DV, MacLean N, Brennan S, Hyer ML, Berger A, Traore T, ... ... Schimmer AD, et al. Preclinical evaluation of the selective small-molecule UBA1 inhibitor, TAK-243, in acute myeloid leukemia. Leukemia. PMID 29884901 DOI: 10.1038/S41375-018-0167-0 |
0.425 |
|
| 2018 |
Pinho P, Kylefjord H, Rraklli V, Rydergård C, Rizoska B, Eneroth A, Bylund J, Moses S, Norin S, Bethell R, Bankar A, Siriwardena TP, Minden MD, Schimmer AD, Albertella M, et al. Protides of 5-Fluorotroxacitabine Display Potent Anti-Proliferative Properties and Circumvent Deoxycytidine Kinase-Mediated Resistance Associated with Cytotoxic Cytidine Analogues; A Novel Approach for Acute Myeloid Leukemia Blood. 132: 3497-3497. DOI: 10.1182/blood-2018-99-114440 |
0.371 |
|
| 2018 |
Bankar A, Siriwardena TP, Rizoska B, Rydergård C, Kylefjord H, Rraklli V, Eneroth A, Pinho P, Norin S, Bylund J, Moses S, Bethell R, Kavanagh S, Wang X, Hurren R, ... ... Schimmer AD, et al. 5-Fluorotroxacitabine Displays Potent Anti-Leukemic Effects and Circumvents Resistance to Ara-C Blood. 132: 3939-3939. DOI: 10.1182/blood-2018-99-114345 |
0.371 |
|
| 2018 |
Singh RP, Jeyaraju DV, Voisin V, Xu C, Barghout SH, Khan DH, Hurren R, Gronda M, Wang X, Jitkova Y, Sharon D, Liyanage SU, Soriano J, Lechman, ER, ... ... Schimmer A, et al. Targeting the Mitochondrial Metallochaperone Cox17 Reduces DNA Methylation and Promotes AML Differentiation through a Copper Dependent Mechanism Blood. 132: 1339-1339. DOI: 10.1182/Blood-2018-99-111015 |
0.522 |
|
| 2018 |
Mirali S, Aaron B, Voisin V, Qiu Y, Hoff FW, Hurren R, Gronda M, Jitkova Y, Xu GW, MacLean N, Wang X, Horton TM, Kornblau SM, Chan SM, Bader GD, ... Schimmer A, et al. The Mitochondrial Protease, Neurolysin (NLN), Regulates Respiratory Chain Supercomplex Formation and Represents a New Therapeutic Target for AML Blood. 132: 1335-1335. DOI: 10.1182/Blood-2018-99-110869 |
0.48 |
|
| 2018 |
Barghout SH, MacLean N, Xu GW, Thomas G, Blatman Z, Hurren R, Schimmer AD. A Genome-Wide CRISPR/Cas9 Knockout Screen Identifies BEND3 As a Determinant of Sensitivity to UBA1 Inhibition in Acute Myeloid Leukemia Blood. 132: 1350-1350. DOI: 10.1182/blood-2018-99-110406 |
0.379 |
|
| 2018 |
Thomas G, Garcia Prat L, Gronda M, Hurren R, MacLean N, Wang X, Aaron B, Dick JE, Schimmer AD. The Metabolic Enzyme Hexokinase 2 Localizes to the Nucleus in AML and Normal Hematopoietic Stem/Progenitor Cells to Maintain Stemness Blood. 132: 2795-2795. DOI: 10.1182/blood-2018-99-110021 |
0.33 |
|
| 2018 |
Schimmer A. Mitochondrial Dysfunction in Normal and Malignant Hematopoiesis Blood. 132: SCI-11-SCI-11. DOI: 10.1182/Blood-2018-99-109470 |
0.492 |
|
| 2018 |
Murphy T, Zou J, Daher-Reyes GS, Gupta V, McNamara CJ, Minden MD, Schimmer AD, Sibai H, Yee KW, Stockley TL, Kamel-Reid S, Maze D, Bratman S, Schuh A, Chan SM. Delayed Hematologic Recovery in AML Patients after Induction Chemotherapy Is Associated with Inferior Relapse-Free Survival and Persistence of Preleukemic Mutations Blood. 132: 992-992. DOI: 10.1016/J.Clml.2019.07.113 |
0.32 |
|
| 2017 |
Chen Y, Pourabdollah M, Atenafu EG, Tierens A, Schimmer A, Chang H. Re-evaluation of acute erythroid leukemia according to the 2016 WHO classification. Leukemia Research. 61: 39-43. PMID 28886412 DOI: 10.1016/J.Leukres.2017.08.011 |
0.363 |
|
| 2017 |
Schimmer AD. Novel Mitochondrial Mechanisms of Cytarabine Resistance in Primary AML Cells. Cancer Discovery. 7: 670-672. PMID 28684410 DOI: 10.1158/2159-8290.CD-17-0476 |
0.364 |
|
| 2017 |
Khoral P, Atenafu EG, Craddock KJ, Schimmer A, Chang H. Prognostic Effect of Complex Karyotype, Monosomal Karyotype, and Chromosome 17 Abnormalities in B-Cell Acute Lymphoblastic Leukemia. Clinical Lymphoma, Myeloma & Leukemia. 17: 215-219. PMID 28395813 DOI: 10.1016/J.Clml.2017.02.009 |
0.324 |
|
| 2017 |
Liyanage SU, Hurren R, Voisin V, Bridon G, Wang X, Xu C, MacLean N, Siriwardena TP, Gronda M, Yehudai D, Sriskanthadevan S, Avizonis D, Shamas-Din A, Minden MD, Bader GD, ... ... Schimmer AD, et al. Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML. Blood. PMID 28283480 DOI: 10.1182/Blood-2016-10-741207 |
0.372 |
|
| 2016 |
Liyanage SU, Coyaud E, Laurent EM, Hurren R, Maclean N, Wood SR, Kazak L, Shamas-Din A, Holt I, Raught B, Schimmer A. Characterizing the mitochondrial DNA polymerase gamma interactome by BioID identifies Ruvbl2 localizes to the mitochondria. Mitochondrion. PMID 27845271 DOI: 10.1016/J.Mito.2016.11.001 |
0.321 |
|
| 2016 |
Matre P, Velez J, Jacamo R, Qi Y, Su X, Cai T, Chan SM, Lodi A, Sweeney SR, Ma H, Davis RE, Baran N, Haferlach T, Su X, Flores ER, ... ... Schimmer AD, et al. Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes. Oncotarget. PMID 27806325 DOI: 10.18632/Oncotarget.12944 |
0.425 |
|
| 2016 |
Reed GA, Schiller GJ, Kambhampati S, Tallman MS, Douer D, Minden MD, Yee KW, Gupta V, Brandwein J, Jitkova Y, Gronda M, Hurren R, Shamas-Din A, Schuh AC, Schimmer AD. A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia. Cancer Medicine. PMID 27734609 DOI: 10.1002/cam4.845 |
0.306 |
|
| 2016 |
Deotare U, Shaheen M, Brandwein JM, Pitcher B, Kamel-Reid S, Yee KW, Schimmer A, Minden MD, Gupta V, Schuh AC. Predictive value of molecular remissions postconsolidation chemotherapy in patients with Core Binding Factor Acute Myeloid Leukemia (CBF-AML) - a single center analysis. Hematological Oncology. PMID 27597292 DOI: 10.1002/Hon.2341 |
0.303 |
|
| 2016 |
Rotin LE, MacLean N, Aman A, Gronda M, Lin FH, Hurren R, Wang X, Wrana JL, Datti A, Al-Awar R, Minden MD, Schimmer AD. Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells. Haematologica. PMID 27587383 DOI: 10.3324/haematol.2016.146894 |
0.339 |
|
| 2016 |
Jones RA, Robinson TJ, Liu JC, Shrestha M, Voisin V, Ju Y, Chung PE, Pellecchia G, Fell VL, Bae S, Muthuswamy L, Datti A, Egan SE, Jiang Z, Leone G, ... ... Schimmer A, et al. RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation. The Journal of Clinical Investigation. PMID 27571409 DOI: 10.1172/Jci81568 |
0.468 |
|
| 2016 |
Jeyaraju DV, Hurren R, Wang X, MacLean N, Gronda M, Shamas-Din A, Minden MD, Giaever G, Schimmer AD. A novel isoflavone, ME-344, targets the cytoskeleton in acute myeloid leukemia. Oncotarget. PMID 27391350 DOI: 10.18632/Oncotarget.10446 |
0.451 |
|
| 2016 |
Rotin LE, Gronda M, Hurren R, Wang XM, Minden MD, Slassi M, Schimmer AD. Investigating the synergistic mechanism between ibrutinib and daunorubicin in acute myeloid leukemia cells. Leukemia & Lymphoma. 1-11. PMID 26732203 DOI: 10.3109/10428194.2016.1138292 |
0.317 |
|
| 2016 |
Wang Z, Choi J, Dove P, Wang C, Schimmer AD, Petrova PS, Uger RA, Slassi M. TTI-281, an Orally Bioavailable Bromodomain and Extraterminal Domain (BET) Inhibitor, Is a Promising Candidate for the Treatment of Multiple Myeloma Blood. 128: 2095-2095. DOI: 10.1182/blood.v128.22.2095.2095 |
0.302 |
|
| 2016 |
Liyanage SU, Hurren R, Voisin V, Xiaoming W, Bridon G, Xu C, MacLean N, Siriwardena T, Shamas-Din A, Sriskanthadevan S, Minden MD, Bader GD, Laposa R, Schimmer AD. Leveraging Increased Nucleoside Kinase Activity to Selectively Deplete Mitochondrial DNA (mtDNA), Impair Oxidative Phosphorylation, and Target AML Cells Blood. 128: 1573-1573. DOI: 10.1182/Blood.V128.22.1573.1573 |
0.402 |
|
| 2016 |
Jeyaraju DV, Voisin V, Xu C, Hurren R, Gronda M, Wang X, Jitkova Y, Soriano J, MacLean N, Bader GD, Schimmer AD. Inhibition of the Mitochondrial Protein Import Machinery Is Selectively Cytotoxic to Acute Myeloid Leukemia (AML) Cells and Stem Cells Blood. 128: 1572-1572. DOI: 10.1182/BLOOD.V128.22.1572.1572 |
0.384 |
|
| 2016 |
Khan DH, Mullokandov M, Wu Y, Gronda M, Hurren R, Wang X, MacLean N, Laister RC, Gross A, Schimmer AD. The Mitochondrial Carrier Homolog 2 (MTCH2) Regulates the Differentiation of AML Cells By Influencing the Localization of Pyruvate Dehydrogenase Complex and H3 and H4 Histone Acetylation Blood. 128: 1562-1562. DOI: 10.1182/Blood.V128.22.1562.1562 |
0.374 |
|
| 2016 |
Liyanage S, Hurren R, Wang X, Maclean N, Laposa R, Schimmer A. Abstract 210: Targeting the mitochondrial DNA polymerase gamma with 2’3’-dideoxycytidine as a novel therapeutic strategy for acute myeloid leukemia Cancer Research. 76: 210-210. DOI: 10.1158/1538-7445.Am2016-210 |
0.548 |
|
| 2015 |
Rotin LE, Gronda M, MacLean N, Hurren R, Wang X, Lin FH, Wrana J, Datti A, Barber DL, Minden MD, Slassi M, Schimmer AD. Ibrutinib synergizes with poly(ADP-ribose) glycohydrolase inhibitors to induce cell death in AML cells via a BTK-independent mechanism. Oncotarget. PMID 26624983 DOI: 10.18632/oncotarget.6409 |
0.463 |
|
| 2015 |
Deotare U, Yee KW, Le LW, Porwit A, Tierens A, Musani R, Barth D, Torlakovic E, Schimmer A, Schuh AC, Seftel M, Minden MD, Gupta V, Hyjek E. Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation: 10-colour flow cytometry diagnosis and HyperCVAD therapy. American Journal of Hematology. PMID 26619305 DOI: 10.1002/Ajh.24258 |
0.312 |
|
| 2015 |
Bartoszko J, Panzarella T, Lau A, Schimmer A, Schuh A, Shanavas M, Yee K, Gupta V. Effect of Red Blood Cell Transfusion Dependence on the Natural History of Myeloproliferative Neoplasm-Associated Myelofibrosis. Clinical Lymphoma, Myeloma & Leukemia. 15: e151-6. PMID 26566925 DOI: 10.1016/J.Clml.2015.09.001 |
0.305 |
|
| 2015 |
Bralha FN, Liyanage SU, Hurren R, Wang X, Son MH, Fung TA, Chingcuanco FB, Tung AY, Andreazza AC, Psarianos P, Schimmer AD, Salmena L, Laposa RR. Targeting mitochondrial RNA polymerase in acute myeloid leukemia. Oncotarget. 6: 37216-28. PMID 26484416 DOI: 10.18632/Oncotarget.6129 |
0.353 |
|
| 2015 |
Lee EA, Angka L, Rota SG, Hanlon T, Mitchell A, Hurren R, Wang XM, Gronda M, Boyaci E, Bojko B, Minden M, Sriskanthadevan S, Datti A, Wrana JL, Edginton A, ... ... Schimmer AD, et al. Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death. Cancer Research. 75: 2478-88. PMID 26077472 DOI: 10.1158/0008-5472.Can-14-2676 |
0.419 |
|
| 2015 |
Cole A, Wang Z, Coyaud E, Voisin V, Gronda M, Jitkova Y, Mattson R, Hurren R, Babovic S, Maclean N, Restall I, Wang X, Jeyaraju DV, Sukhai MA, Prabha S, ... ... Schimmer AD, et al. Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia. Cancer Cell. 27: 864-76. PMID 26058080 DOI: 10.1016/J.Ccell.2015.05.004 |
0.401 |
|
| 2015 |
Jean SR, Tulumello DV, Riganti C, Liyanage SU, Schimmer AD, Kelley SO. Mitochondrial Targeting of Doxorubicin Eliminates Nuclear Effects Associated with Cardiotoxicity. Acs Chemical Biology. 10: 2007-15. PMID 26038829 DOI: 10.1021/Acschembio.5B00268 |
0.345 |
|
| 2015 |
Yeung M, Hurren R, Nemr C, Wang X, Hershenfeld S, Gronda M, Liyanage S, Wu Y, Augustine J, Lee EA, Spagnuolo PA, Southall N, Chen C, Zheng W, Jeyaraju DV, ... ... Schimmer AD, et al. Mitochondrial DNA damage by bleomycin induces AML cell death. Apoptosis : An International Journal On Programmed Cell Death. 20: 811-20. PMID 25820141 DOI: 10.1007/S10495-015-1119-Z |
0.37 |
|
| 2015 |
Sriskanthadevan S, Jeyaraju DV, Chung TE, Prabha S, Xu W, Skrtic M, Jhas B, Hurren R, Gronda M, Wang X, Jitkova Y, Sukhai MA, Lin FH, Maclean N, Laister R, ... ... Schimmer AD, et al. AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress. Blood. 125: 2120-30. PMID 25631767 DOI: 10.1182/Blood-2014-08-594408 |
0.752 |
|
| 2015 |
Wang Z, Dove P, Shamas-Din A, Hurren R, Wang X, MacLean N, Gronda M, Bo F, Li J, Skorupski C, Hadri W, O'Neill D, Aman A, Al-awar R, Minden MD, ... ... Schimmer AD, et al. The Highly Potent Bromodomain (BRD) Inhibitor FV-281 Displays Preclinical Efficacy in Acute Myeloid Leukemia (AML) Blood. 126: 1364-1364. DOI: 10.1182/BLOOD.V126.23.1364.1364 |
0.395 |
|
| 2015 |
Liyanage S, Hurren R, Laposa R, Schimmer A. Abstract 3039: Targeting mitochondrial DNA polymerase gamma (POLG) as a novel therapeutic strategy for acute myeloid leukemia (AML) Cancer Research. 75: 3039-3039. DOI: 10.1158/1538-7445.Am2015-3039 |
0.485 |
|
| 2014 |
Kouznetsova J, Sun W, Martínez-Romero C, Tawa G, Shinn P, Chen CZ, Schimmer A, Sanderson P, McKew JC, Zheng W, García-Sastre A. Identification of 53 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugs. Emerging Microbes & Infections. 3: e84. PMID 26038505 DOI: 10.1038/Emi.2014.88 |
0.309 |
|
| 2014 |
Pandyra A, Mullen PJ, Kalkat M, Yu R, Pong JT, Li Z, Trudel S, Lang KS, Minden MD, Schimmer AD, Penn LZ. Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop. Cancer Research. 74: 4772-82. PMID 24994712 DOI: 10.1158/0008-5472.Can-14-0130 |
0.361 |
|
| 2014 |
Yip KW, Zhang Z, Sakemura-Nakatsugawa N, Huang JW, Vu NM, Chiang YK, Lin CL, Kwan JY, Yue S, Jitkova Y, To T, Zahedi P, Pai EF, Schimmer AD, Lovell JF, et al. A porphodimethene chemical inhibitor of uroporphyrinogen decarboxylase. Plos One. 9: e89889. PMID 24587102 DOI: 10.1371/Journal.Pone.0089889 |
0.328 |
|
| 2014 |
Lee EA, Angka L, Rota S, Hanlon T, Hurren R, Wang XM, Gronda M, Bernard D, Minden MD, Mitchell A, Edginton A, Sriskanthadevan S, Datti A, Wrana J, Joseph JW, ... ... Schimmer AD, et al. Inhibition of Fatty Acid Oxidation with Avocatin B Selectively Targets AML Cells and Leukemia Stem Cells Blood. 124: 268-268. DOI: 10.1182/BLOOD.V124.21.268.268 |
0.414 |
|
| 2014 |
Rotin LE, Gronda M, Maclean N, Lin F, Wrana J, Datti A, Barber DL, Moran MF, Minden MD, Slassi M, Schimmer AD. Ibrutinib Sensitizes AML Cells to ROS Inducers Via a BTK-Independent Mechanism Blood. 124: 2226-2226. DOI: 10.1182/BLOOD.V124.21.2226.2226 |
0.462 |
|
| 2014 |
Liyanage S, Hurren R, Laposa R, Schimmer A. Abstract 4317: Inhibiting the mitochondrial DNA polymerase gamma (POLG) with 2′,3′-dideoxycytidine reduces oxidative phosphorylation and increases apoptosis in acute myeloid leukemia (AML) cells Cancer Research. 74: 4317-4317. DOI: 10.1158/1538-7445.Am2014-4317 |
0.461 |
|
| 2014 |
Yip KW, Zhang Z, Sakemura-Nakatsugawa N, Huang J, Yue S, Jitkova Y, To T, Pai E, Schimmer A, Lovell J, Sessler J, Liu F. Abstract 2510: A porphodimethene chemical inhibitor of uroporphyrinogen decarboxylase Cancer Research. 74: 2510-2510. DOI: 10.1158/1538-7445.Am2014-2510 |
0.421 |
|
| 2013 |
Robinson TJ, Liu JC, Vizeacoumar F, Sun T, Maclean N, Egan SE, Schimmer AD, Datti A, Zacksenhaus E. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. Plos One. 8: e78641. PMID 24265703 DOI: 10.1371/journal.pone.0078641 |
0.319 |
|
| 2013 |
Niewerth D, Franke NE, Jansen G, Assaraf YG, van Meerloo J, Kirk CJ, Degenhardt J, Anderl J, Schimmer AD, Zweegman S, de Haas V, Horton TM, Kaspers GJ, Cloos J. Higher ratio immune versus constitutive proteasome level as novel indicator of sensitivity of pediatric acute leukemia cells to proteasome inhibitors. Haematologica. 98: 1896-904. PMID 24056819 DOI: 10.3324/haematol.2013.092411 |
0.318 |
|
| 2013 |
Lenarduzzi M, Hui AB, Yue S, Ito E, Shi W, Williams J, Bruce J, Sakemura-Nakatsugawa N, Xu W, Schimmer A, Liu FF. Hemochromatosis enhances tumor progression via upregulation of intracellular iron in head and neck cancer. Plos One. 8: e74075. PMID 23991213 DOI: 10.1371/Journal.Pone.0074075 |
0.312 |
|
| 2013 |
Zhang J, Tang J, Cao B, Zhang Z, Li J, Schimmer AD, He S, Mao X. The natural pesticide dihydrorotenone induces human plasma cell apoptosis by triggering endoplasmic reticulum stress and activating p38 signaling pathway. Plos One. 8: e69911. PMID 23922854 DOI: 10.1371/journal.pone.0069911 |
0.304 |
|
| 2013 |
Mourtada R, Fonseca SB, Wisnovsky SP, Pereira MP, Wang X, Hurren R, Parfitt J, Larsen L, Smith RA, Murphy MP, Schimmer AD, Kelley SO. Re-directing an alkylating agent to mitochondria alters drug target and cell death mechanism. Plos One. 8: e60253. PMID 23585833 DOI: 10.1371/Journal.Pone.0060253 |
0.372 |
|
| 2013 |
Jhas B, Sriskanthadevan S, Skrtic M, Sukhai MA, Voisin V, Jitkova Y, Gronda M, Hurren R, Laister RC, Bader GD, Minden MD, Schimmer AD. Metabolic adaptation to chronic inhibition of mitochondrial protein synthesis in acute myeloid leukemia cells. Plos One. 8: e58367. PMID 23520503 DOI: 10.1371/Journal.Pone.0058367 |
0.764 |
|
| 2013 |
Goard CA, Schimmer AD. An evidence-based review of obatoclax mesylate in the treatment of hematological malignancies. Core Evidence. 8: 15-26. PMID 23515850 DOI: 10.2147/Ce.S42568 |
0.319 |
|
| 2013 |
Spagnuolo PA, Hurren R, Gronda M, Maclean N, Datti A, Basheer A, Lin FH, Wang X, Wrana J, Schimmer AD. Inhibition of intracellular dipeptidyl peptidases 8 and 9 enhances parthenolide's anti-leukemic activity Leukemia. 27: 1236-1244. PMID 23318959 DOI: 10.1038/leu.2013.9 |
0.434 |
|
| 2013 |
Sukhai MA, Prabha S, Hurren R, Rutledge AC, Lee AY, Sriskanthadevan S, Sun H, Wang X, Skrtic M, Seneviratne A, Cusimano M, Jhas B, Gronda M, MacLean N, Cho EE, ... ... Schimmer AD, et al. Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors Journal of Clinical Investigation. 123: 315-328. PMID 23202731 DOI: 10.1172/Jci64180 |
0.767 |
|
| 2013 |
Xu W, Lukkarila JL, da Silva SR, Paiva SL, Gunning PT, Schimmer AD. Targeting the ubiquitin E1 as a novel anti-cancer strategy. Current Pharmaceutical Design. 19: 3201-9. PMID 23151135 DOI: 10.2174/1381612811319180004 |
0.323 |
|
| 2013 |
Matre P, Samudio I, Jacamo R, Wang Y, Wang J, Davis RE, Su X, Schindela S, Newman R, Hu J, Haferlach T, Andreeff M, Flores ER, Schimmer A, Konopleva M. Unraveling The Molecular and Metabolic Basis For Glutamine Addiction In Leukemias Blood. 122: 606-606. DOI: 10.1182/Blood.V122.21.606.606 |
0.505 |
|
| 2013 |
Khoury H, Ruijuan H, Schimmer A, Hostetler K, Minden MD. ODE-Adefovir As Potential Therapeutic Agent In AML Blood. 122: 3970-3970. DOI: 10.1182/Blood.V122.21.3970.3970 |
0.47 |
|
| 2013 |
Brandwein JM, Hedley D, Chow S, Yee K, Schuh AC, Gupta V, Schimmer A, Minden MD. A Phase I Study Of Nilotinib As a c-Kit Inhibitor Combined With Re-Induction Chemotherapy For Relapsed and Refractory c-Kit Positive Acute Myeloid Leukemia Blood. 122: 3961-3961. DOI: 10.1182/Blood.V122.21.3961.3961 |
0.343 |
|
| 2013 |
Cole A, Wang Z, Mattson R, Coyaud E, Hurren R, Gronda M, Lin F, Maclean N, Leung E, Qiu Y, Zhang N, Coombes KR, Minden MD, Houry WA, Hao Z, ... ... Schimmer A, et al. Targeting The Mitochondrial ClpP As a Novel Therapeutic Strategy For Acute Myeloid Leukemia Blood. 122: 3937-3937. DOI: 10.1182/Blood.V122.21.3937.3937 |
0.525 |
|
| 2013 |
Wang Z, Dove P, Wang X, Goard CA, Li Z, Nachman A, Oh YJ, Hurren R, Ruschak A, Climie S, O'Neill D, Press B, Griffin C, Undzys E, Aman A, ... ... Schimmer A, et al. FV-162 Is a Novel Orally Bioavailable Proteasome Inhibitor With Improved Pharmacokinetics That Displays Preclinical Efficacy In Vitro and In Vivo Blood. 122: 1988-1988. DOI: 10.1182/Blood.V122.21.1988.1988 |
0.386 |
|
| 2013 |
Rashid A, Fateen M, Schimmer A, Minden M. Abstract 4123: Investigation of growth factor signaling through macrophage colony stimulating factor (CSF-1) and its receptor (FMS) in the bone marrow stromal microenvironment in acute myeloid leukemia (AML). Cancer Research. 73: 4123-4123. DOI: 10.1158/1538-7445.Am2013-4123 |
0.399 |
|
| 2012 |
Beheshti Zavareh R, Sukhai MA, Hurren R, Gronda M, Wang X, Simpson CD, Maclean N, Zih F, Ketela T, Swallow CJ, Moffat J, Rose DR, Schachter H, Schimmer AD, Dennis JW. Suppression of cancer progression by MGAT1 shRNA knockdown. Plos One. 7: e43721. PMID 22957033 DOI: 10.1371/Journal.Pone.0043721 |
0.787 |
|
| 2012 |
Mamaghani S, Simpson CD, Cao PM, Cheung M, Chow S, Bandarchi B, Schimmer AD, Hedley DW. Glycogen synthase kinase-3 inhibition sensitizes pancreatic cancer cells to TRAIL-induced apoptosis. Plos One. 7: e41102. PMID 22829912 DOI: 10.1371/journal.pone.0041102 |
0.361 |
|
| 2012 |
Simpson CD, Hurren R, Kasimer D, MacLean N, Eberhard Y, Ketela T, Moffat J, Schimmer AD. A genome wide shRNA screen identifies α/β hydrolase domain containing 4 (ABHD4) as a novel regulator of anoikis resistance Apoptosis. 17: 666-678. PMID 22488300 DOI: 10.1007/S10495-012-0723-4 |
0.311 |
|
| 2012 |
Schimmer AD, Skrtić M. Therapeutic potential of mitochondrial translation inhibition for treatment of acute myeloid leukemia. Expert Review of Hematology. 5: 117-9. PMID 22475277 DOI: 10.1586/Ehm.12.8 |
0.71 |
|
| 2012 |
de Wilt LH, Jansen G, Assaraf YG, van Meerloo J, Cloos J, Schimmer AD, Chan ET, Kirk CJ, Peters GJ, Kruyt FA. Proteasome-based mechanisms of intrinsic and acquired bortezomib resistance in non-small cell lung cancer. Biochemical Pharmacology. 83: 207-17. PMID 22027222 DOI: 10.1016/j.bcp.2011.10.009 |
0.31 |
|
| 2012 |
Cole A, Wang Z, Mattson R, Hurren R, Lin F, Gronda M, Maclean N, Isaac M, Leung E, Babu M, Sukhai MA, Houry WA, Schimmer AD. Targeting the Mammalian Mitochondrial Clpp (mClpP) As a Novel Therapeutic Strategy for Acute Myeloid Leukemia Blood. 120: 3603-3603. DOI: 10.1182/blood.v120.21.3603.3603 |
0.485 |
|
| 2012 |
Sriskanthadevan S, Chung TE, Skrtic M, Jhas B, Hurren R, Gronda M, Wang XM, Jitkova Y, Sukhai MA, Lin F, Maclean N, Laister RC, Mullen P, Xie S, Penn L, ... ... Schimmer AD, et al. AML Cells Have Altered Mitochondrial Biogenesis and Low Spare Reserve Capacity in Their Respiratory Chain That Renders Them Susceptible to Oxidative Metabolic Stress. Blood. 120: 2581-2581. DOI: 10.1182/Blood.V120.21.2581.2581 |
0.761 |
|
| 2012 |
Bozhena J, Sriskanthadevan S, Skrtic M, Sukhai MA, Voisin V, Jitkova Y, Gronda M, Hurren R, Wang X, Laister RC, Bader GD, Minden MD, Schimmer AD. Chronic Inhibition of Mitochondrial Translation Alters Metabolism and Stemness in AML Blood. 120: 1364-1364. DOI: 10.1182/Blood.V120.21.1364.1364 |
0.762 |
|
| 2012 |
Sriskanthadevan S, Skrtic M, Jhas B, Jitkova Y, Hurren R, Gronda M, Wang X, Sukhai MA, Minden M, Schimmer A. Abstract 1123: AML cells have low reserve capacity in their respiratory chain complexes leading to increased sensitivity to palmitate-induced cell death Cancer Research. 72: 1123-1123. DOI: 10.1158/1538-7445.Am2012-1123 |
0.772 |
|
| 2011 |
Skrti? M, Sriskanthadevan S, Jhas B, Gebbia M, Wang X, Wang Z, Hurren R, Jitkova Y, Gronda M, Maclean N, Lai CK, Eberhard Y, Bartoszko J, Spagnuolo P, Rutledge AC, ... ... Schimmer AD, et al. Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell. 20: 674-88. PMID 22094260 DOI: 10.1016/J.Ccr.2011.10.015 |
0.415 |
|
| 2011 |
Fonseca SB, Pereira MP, Mourtada R, Gronda M, Horton KL, Hurren R, Minden MD, Schimmer AD, Kelley SO. Rerouting chlorambucil to mitochondria combats drug deactivation and resistance in cancer cells. Chemistry & Biology. 18: 445-53. PMID 21513881 DOI: 10.1016/J.Chembiol.2011.02.010 |
0.38 |
|
| 2011 |
Ito E, Yue S, Moriyama EH, Hui AB, Kim I, Shi W, Alajez NM, Bhogal N, Li G, Datti A, Schimmer AD, Wilson BC, Liu PP, Durocher D, Neel BG, et al. Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer. Science Translational Medicine. 3: 67ra7. PMID 21270338 DOI: 10.1126/Scitranslmed.3001922 |
0.328 |
|
| 2011 |
Sukhai MA, Hurren R, Rutledge A, Livak B, Wang X, Seneviratne A, Cusimano MC, Gebbia M, Skrtic M, Sun H, Gronda M, Spagnuolo PA, Urbanus M, Eppert K, Dissanayake D, ... ... Schimmer AD, et al. Lysosomal Disruption Selectively Targets Leukemia Cells and Leukemia Stem Cells Through A Mechanism Related to Increased Reactive Oxygen Species Production Blood. 118: 61-61. DOI: 10.1182/Blood.V118.21.61.61 |
0.783 |
|
| 2011 |
Yee K, Bansal S, Brandwein J, Minden MD, Schimmer A, Gupta V, Dharman A, Cserti-Gazdewich C, Schuh A. Azacitidine Has Limited Activity in Patients with MDS and AML Blood. 118: 5057-5057. DOI: 10.1182/Blood.V118.21.5057.5057 |
0.31 |
|
| 2011 |
Sriskanthadevan S, Marko S, Livak B, Jitkova Y, Hurren R, Gronda M, Laister R, Mullen P, Penn L, Minden MD, Schimmer AD. AML Cells Have Increased Mitochondrial Mass but Less Reserve in Their Respiratory Chain Complexes Leading to Heightened Sensitivity to Inhibition of Mitochondrial Protein Translation, Blood. 118: 3585-3585. DOI: 10.1182/Blood.V118.21.3585.3585 |
0.359 |
|
| 2011 |
Skrtic M, Sriskanthadevan S, Livak B, Gebbia M, Wang X, Wang Z, Hurren R, Jitkova Y, Gronda M, Maclean N, Lai C, Eberhard Y, Bartoszko J, Spagnuolo PA, Rutledge A, ... ... Schimmer AD, et al. Inhibition of Mitochondrial Translation As a Therapeutic Strategy for Acute Myeloid Leukemia (AML) Blood. 118: 233-233. DOI: 10.1182/Blood.V118.21.233.233 |
0.771 |
|
| 2011 |
Pandyra A, Sobol P, Sharmeen S, Schimmer A, Penn L. Abstract C170: The combination of statins and dipyridamole is effective preclinically in AML, MM, and breast cancer. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-C170 |
0.491 |
|
| 2010 |
Sharmeen S, Skrtic M, Sukhai MA, Hurren R, Gronda M, Wang X, Fonseca SB, Sun H, Wood TE, Ward R, Minden MD, Batey RA, Datti A, Wrana J, Kelley SO, ... Schimmer AD, et al. The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells. Blood. 116: 3593-603. PMID 20644115 DOI: 10.1182/Blood-2010-01-262675 |
0.767 |
|
| 2010 |
Li X, Wood TE, Sprangers R, Jansen G, Franke NE, Mao X, Wang X, Zhang Y, Verbrugge SE, Adomat H, Li ZH, Trudel S, Chen C, Religa TL, Jamal N, ... ... Schimmer AD, et al. Effect of noncompetitive proteasome inhibition on bortezomib resistance. Journal of the National Cancer Institute. 102: 1069-82. PMID 20505154 DOI: 10.1093/Jnci/Djq198 |
0.439 |
|
| 2010 |
Tsao T, Kornblau S, Safe S, Watt JC, Ruvolo V, Chen W, Qiu Y, Coombes KR, Ju Z, Abdelrahim M, Schober W, Ling X, Kardassis D, Meyer C, Schimmer A, et al. Role of peroxisome proliferator-activated receptor-gamma and its coactivator DRIP205 in cellular responses to CDDO (RTA-401) in acute myelogenous leukemia. Cancer Research. 70: 4949-60. PMID 20501850 DOI: 10.1158/0008-5472.Can-09-1962 |
0.45 |
|
| 2010 |
Spagnuolo PA, Hu J, Hurren R, Wang X, Gronda M, Sukhai MA, Di Meo A, Boss J, Ashali I, Beheshti Zavareh R, Fine N, Simpson CD, Sharmeen S, Rottapel R, Schimmer AD. The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma. Blood. 115: 4824-33. PMID 20348394 DOI: 10.1182/Blood-2009-09-243055 |
0.809 |
|
| 2010 |
Xu GW, Ali M, Wood TE, Wong D, Maclean N, Wang X, Gronda M, Skrtic M, Li X, Hurren R, Mao X, Venkatesan M, Beheshti Zavareh R, Ketela T, Reed JC, ... ... Schimmer AD, et al. The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood. 115: 2251-9. PMID 20075161 DOI: 10.1182/Blood-2009-07-231191 |
0.772 |
|
| 2010 |
Rodin G, Lo C, Rydall A, Chan A, Andrews J, Minden M, Schimmer A, Brandwein J, Zimmermann C. Comparison of distress in patients with acute leukemia and advanced solid tumors. Journal of Clinical Oncology. 28: e19537-e19537. DOI: 10.1200/Jco.2010.28.15_Suppl.E19537 |
0.326 |
|
| 2010 |
Yee KW, Chen HT, Brandwein J, Chow S, Sanfelice D, Hedley D, Gupta V, Schimmer A, Sidor CF, Fletcher G, Arnott J, Bray M, Minden MD, Schuh A. A Phase I Study of ENMD-2076 In Patients with Relapsed or Refractory Leukemia Blood. 116: 3307-3307. DOI: 10.1182/Blood.V116.21.3307.3307 |
0.359 |
|
| 2010 |
Sukhai MA, Li X, Hurren R, Wang X, Marko S, Sun H, Gronda M, Seneviratne A, Dissanayake D, Chow S, Bremner R, Hedley D, Minden MD, Pamela O, Schimmer A. The Anti-Malarial Mefloquine Demonstrates Preclinical Activity In Leukemia and Myeloma, and Is Dependent Upon Toll-Like Receptor Signaling for Its Cytotoxicity Blood. 116: 290-290. DOI: 10.1182/Blood.V116.21.290.290 |
0.542 |
|
| 2010 |
Al-Khabori MK, Yee K, Gupta V, Schimmer A, Schuh A, Minden MD, Brandwein J. Validation of Monosomal Karyotype Based Model In the Risk Stratification of Acute Myeloid Leukemia Blood. 116: 2745-2745. DOI: 10.1182/Blood.V116.21.2745.2745 |
0.317 |
|
| 2010 |
Cao B, Hou T, Chen S, Wu D, Sun A, Qiu H, Wang W, Schimmer A, Mao X. Clioquinol Arrests Cell Cycle at G1 Phase and Triggers Intrinsic Apoptosis In Myeloma and Leukemia Cells by Inhibiting Histone Deacetylases Blood. 116: 1836-1836. DOI: 10.1182/Blood.V116.21.1836.1836 |
0.499 |
|
| 2010 |
Franke N, Niewerth D, Meerloo Jv, Vojtekova K, Verbrugge SE, Schimmer A, Kaspers G, Jansen G, Cloos J. Abstract A27: Chronic exposure of malignant hematological cell lines to bortezomib induces de novo hot spot mutations in the PSMB5 gene Clinical Cancer Research. 16. DOI: 10.1158/1078-0432.Tcme10-A27 |
0.399 |
|
| 2009 |
Raza A, Galili N, Borthakur G, Carter TH, Claxton DF, Erba HP, DeAngelo DJ, Berger MS, Schimmer A. A safety and schedule seeking trial of Bcl-2 inhibitor obatoclax in previously untreated older patients with acute myeloid leukemia (AML). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: 3579. PMID 27961704 DOI: 10.1200/Jco.2009.27.15_Suppl.3579 |
0.338 |
|
| 2009 |
Ito E, Yip KW, Katz D, Fonseca SB, Hedley DW, Chow S, Xu GW, Wood TE, Bastianutto C, Schimmer AD, Kelley SO, Liu FF. Potential use of cetrimonium bromide as an apoptosis-promoting anticancer agent for head and neck cancer. Molecular Pharmacology. 76: 969-83. PMID 19654225 DOI: 10.1124/Mol.109.055277 |
0.364 |
|
| 2009 |
Eberhard Y, McDermott SP, Wang X, Gronda M, Venugopal A, Wood TE, Hurren R, Datti A, Batey RA, Wrana J, Antholine WE, Dick JE, Dick J, Schimmer AD. Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells. Blood. 114: 3064-73. PMID 19589922 DOI: 10.1182/Blood-2009-03-209965 |
0.399 |
|
| 2009 |
Simpson CD, Mawji IA, Anyiwe K, Williams MA, Wang X, Venugopal AL, Gronda M, Hurren R, Cheng S, Serra S, Beheshti Zavareh R, Datti A, Wrana JL, Ezzat S, Schimmer AD. Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation. Cancer Research. 69: 2739-47. PMID 19293189 DOI: 10.1158/0008-5472.CAN-08-2530 |
0.803 |
|
| 2009 |
Watanabe K, Ambekar C, Wang H, Ciccolini A, Schimmer AD, Dror Y. SBDS-deficiency results in specific hypersensitivity to Fas stimulation and accumulation of Fas at the plasma membrane. Apoptosis : An International Journal On Programmed Cell Death. 14: 77-89. PMID 19009351 DOI: 10.1007/s10495-008-0275-9 |
0.304 |
|
| 2009 |
Sharmeen S, Skrtic M, Sukhai M, Sun J, Hurren R, Gronda M, Wang X, Wood TE, Batey RA, Fonesca S, Kelley S, Datti A, Wrana J, Schimmer AD. Activation of Chloride Channels with the Anti-Parasitic Agent Ivermectin Induces Membrane Hyperpolarization and Cell Death in Leukemia Cells. Blood. 114: 410-410. DOI: 10.1182/Blood.V114.22.410.410 |
0.766 |
|
| 2009 |
Mao X, Wood TE, Hurren R, Tong J, Wang X, Spagnuolo PA, MacLean N, Moran MF, Datti A, Wrana J, Batey RA, Schimmer AD. A Small Molecule Inhibitor of D-Cyclin Transactivation Displays Preclinical Efficacy in Myeloma and Leukemia. Blood. 114: 2036-2036. DOI: 10.1182/Blood.V114.22.2036.2036 |
0.332 |
|
| 2009 |
Page BDG, Fletcher S, Schimmer A, Turkson J, Gunning PT. Abstract C40: Salicylic acid‐based small molecule inhibitors of Stat3 show potent and selective activity in a variety of human cancer cell lines Cancer Research. 69. DOI: 10.1158/0008-5472.Fbcr09-C40 |
0.404 |
|
| 2008 |
Coe E, Schimmer AD. Catalase activity and arsenic sensitivity in acute leukemia. Leukemia & Lymphoma. 49: 1976-81. PMID 18949620 DOI: 10.1080/10428190802353617 |
0.396 |
|
| 2008 |
Beheshti Zavareh R, Lau KS, Hurren R, Datti A, Ashline DJ, Gronda M, Cheung P, Simpson CD, Liu W, Wasylishen AR, Boutros PC, Shi H, Vengopal A, Jurisica I, Penn LZ, ... ... Schimmer AD, et al. Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function. Cancer Research. 68: 6688-97. PMID 18701493 DOI: 10.1158/0008-5472.Can-07-6833 |
0.775 |
|
| 2008 |
Simpson CD, Anyiwe K, Schimmer AD. Anoikis resistance and tumor metastasis. Cancer Letters. 272: 177-85. PMID 18579285 DOI: 10.1016/j.canlet.2008.05.029 |
0.342 |
|
| 2008 |
Mao X, Liang SB, Hurren R, Gronda M, Chow S, Xu GW, Wang X, Beheshti Zavareh R, Jamal N, Messner H, Hedley DW, Datti A, Wrana JL, Zhu Y, Shi CX, ... ... Schimmer AD, et al. Cyproheptadine displays preclinical activity in myeloma and leukemia. Blood. 112: 760-9. PMID 18502826 DOI: 10.1182/blood-2008-02-142687 |
0.796 |
|
| 2008 |
Tiedemann RE, Mao X, Shi CX, Zhu YX, Palmer SE, Sebag M, Marler R, Chesi M, Fonseca R, Bergsagel PL, Schimmer AD, Stewart AK. Identification of kinetin riboside as a repressor of CCND1 and CCND2 with preclinical antimyeloma activity. The Journal of Clinical Investigation. 118: 1750-64. PMID 18431519 DOI: 10.1172/JCI34149 |
0.32 |
|
| 2008 |
Hurren R, Beheshti Zavareh R, Dalili S, Wood T, Rose D, Chang H, Jamal N, Messner H, Batey RA, Schimmer AD. A novel diquinolonium displays preclinical anti-cancer activity and induces caspase-independent cell death. Apoptosis : An International Journal On Programmed Cell Death. 13: 748-55. PMID 18415680 DOI: 10.1007/S10495-008-0209-6 |
0.801 |
|
| 2008 |
Abdelhameed A, Pond GR, Mitsakakis N, Brandwein J, Chun K, Gupta V, Kamel-Reid S, Lipton JH, Minden MD, Schimmer A, Schuh A, Yee K, Messner HA. Outcome of patients who develop acute leukemia or myelodysplasia as a second malignancy after solid tumors treated surgically or with strategies that include chemotherapy and/or radiation. Cancer. 112: 1513-21. PMID 18286528 DOI: 10.1002/Cncr.23325 |
0.325 |
|
| 2008 |
Rujkijyanont P, Watanabe K, Ambekar C, Wang H, Schimmer A, Beyene J, Dror Y. SBDS-deficient cells undergo accelerated apoptosis through the Fas-pathway. Haematologica. 93: 363-71. PMID 18268284 DOI: 10.3324/Haematol.11579 |
0.385 |
|
| 2008 |
Xu GW, Mawji IA, Macrae CJ, Koch CA, Datti A, Wrana JL, Dennis JW, Schimmer AD. A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization. Apoptosis : An International Journal On Programmed Cell Death. 13: 413-22. PMID 18181020 DOI: 10.1007/s10495-007-0175-4 |
0.427 |
|
| 2008 |
Eberhard Y, Venugopal A, Gronda M, Hurren R, Datti A, Wrana J, Antholine WE, Schimmer AD. The off-Patent Anti-Fungal Ciclopirox Olamine Displays Preclinical Activity in Leukemia and Myeloma. Blood. 112: 944-944. DOI: 10.1182/blood.V112.11.944.944 |
0.415 |
|
| 2008 |
Li X, Wood TE, Sprangers R, Mao X, Wang X, Zhang Y, Rose D, Batey RA, Kay LE, Schimmer AD. A Novel Non-Competitive Chemical Proteasome Inhibitor Displays Preclinical Activity in Myeloma and Leukemia. Blood. 112: 1711-1711. DOI: 10.1182/Blood.V112.11.1711.1711 |
0.418 |
|
| 2008 |
Mao X, Wood TW, Wang X, St-Germain J, Moran MF, Datti A, Wrana J, Batey RA, Schimmer AD. A Novel Chromene-Based Pan-PI3 Kinase Inhibitor Displays Preclinical Activity in Leukemia and Myeloma. Blood. 112: 1605-1605. DOI: 10.1182/Blood.V112.11.1605.1605 |
0.415 |
|
| 2007 |
Mawji IA, Simpson CD, Gronda M, Williams MA, Hurren R, Henderson CJ, Datti A, Wrana JL, Schimmer AD. A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis. Cancer Research. 67: 8307-15. PMID 17804746 DOI: 10.1158/0008-5472.CAN-07-1687 |
0.368 |
|
| 2007 |
Mao X, Stewart AK, Hurren R, Gronda M, Lee K, Chow S, Liang S, Trudel S, Hedley DW, Schimmer AD. A High Throughput Screen Identified Cyproheptadine That Decreases D-Type Cyclins, Arrests Cells in the G1 Phase, and Induces Apoptosis in Multiple Myeloma and Leukemia Cells. Blood. 110: 1507-1507. DOI: 10.1182/blood.v110.11.1507.1507 |
0.402 |
|
| 2006 |
Yip KW, Mao X, Au PY, Hedley DW, Chow S, Dalili S, Mocanu JD, Bastianutto C, Schimmer A, Liu FF. Benzethonium chloride: a novel anticancer agent identified by using a cell-based small-molecule screen. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 5557-69. PMID 17000693 DOI: 10.1158/1078-0432.Ccr-06-0536 |
0.344 |
|
| 2006 |
Yip KW, Ito E, Mao X, Au PY, Hedley DW, Mocanu JD, Bastianutto C, Schimmer A, Liu FF. Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent. Molecular Cancer Therapeutics. 5: 2234-40. PMID 16985057 DOI: 10.1158/1535-7163.Mct-06-0134 |
0.453 |
|
| 2006 |
Schimmer AD, Thomas MP, Hurren R, Gronda M, Pellecchia M, Pond GR, Konopleva M, Gurfinkel D, Mawji IA, Brown E, Reed JC. Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors. Cancer Research. 66: 2367-75. PMID 16489043 DOI: 10.1158/0008-5472.CAN-05-1061 |
0.322 |
|
| 2006 |
Tiedemann RE, Mao X, Marler RJ, Reeder CB, Schimmer A, Stewart K. Kinetin Riboside Is a Novel Targeted Inhibitor of CCND1 and CCND2 Transactivation with Substantial Preclinical Anti-Myeloma Activity. Blood. 108: 367-367. DOI: 10.1182/Blood.V108.11.367.367 |
0.457 |
|
| 2006 |
Tiedemann RE, Mao X, Shi C, Zhang YX, Palmer S, Reeder CB, Schimmer A, Stewart K. Chemical Library Screening Identifies Novel Inhibitors of Cyclin D2 (CCND2) Transactivation That Selectively Induce Apoptosis in Multiple Myeloma Cells. Blood. 108: 3421-3421. DOI: 10.1182/Blood.V108.11.3421.3421 |
0.457 |
|
| 2006 |
Storring JM, Brandwein J, Gupta V, Schuh AC, Schimmer A, Yee K, Wells RA, Lipton JH, Messner HA, Xu W, Minden MD. Treatment of Adult Acute Lymphoblastic Leukemia (ALL) with a Modified DFCI Pediatric Regimen - The Princess Margaret Experience. Blood. 108: 1875-1875. DOI: 10.1182/Blood.V108.11.1875.1875 |
0.327 |
|
| 2005 |
Carter BZ, Gronda M, Wang Z, Welsh K, Pinilla C, Andreeff M, Schober WD, Nefzi A, Pond GR, Mawji IA, Houghten RA, Ostresh J, Brandwein J, Minden MD, Schuh AC, ... ... Schimmer AD, et al. Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells Blood. 105: 4043-4050. PMID 15687241 DOI: 10.1182/Blood-2004-08-3168 |
0.359 |
|
| 2004 |
Pham NA, Jacobberger JW, Schimmer AD, Cao P, Gronda M, Hedley DW. The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice. Molecular Cancer Therapeutics. 3: 1239-48. PMID 15486191 |
0.418 |
|
| 2004 |
Wang Z, Cuddy M, Samuel T, Welsh K, Schimmer A, Hanaii F, Houghten R, Pinilla C, Reed JC. Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors. The Journal of Biological Chemistry. 279: 48168-76. PMID 15337764 DOI: 10.1074/Jbc.M405022200 |
0.424 |
|
| 2004 |
Schimmer AD, Welsh K, Pinilla C, Wang Z, Krajewska M, Bonneau MJ, Pedersen IM, Kitada S, Scott FL, Bailly-Maitre B, Glinsky G, Scudiero D, Sausville E, Salvesen G, Nefzi A, et al. Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity. Cancer Cell. 5: 25-35. PMID 14749124 DOI: 10.1016/S1535-6108(03)00332-5 |
0.353 |
|
| 2004 |
Schimmer AD, Gronda M, Wang Z, Welsh K, Pinilla C, Andreeff M, Schober WD, Nefzi A, Houghten R, Brandwein J, Minden MD, Schuh A, Wells RA, Messner H, Reed JC, et al. Small-Molecule XIAP Inhibitors Derepress Downstream Effector Caspases and Induce Apoptosis of Leukemia Cell Lines and Patient Samples. Blood. 104: 759-759. DOI: 10.1182/Blood.V104.11.759.759 |
0.381 |
|
| 2004 |
Gu C, Zheng HJ, Chan LS, Brandwein J, Kamel-Reid S, Minden MD, Schimmer AD, Schuh AC, Wells RA. Disordered Expression of HIPK Family Members in MDS and AML. Blood. 104: 4311-4311. DOI: 10.1182/Blood.V104.11.4311.4311 |
0.34 |
|
| 2004 |
Ichim CV, Sukhai MA, Brandwein J, Minden MD, Schimmer AD, Schuh AC, Kamel-Reid S, Iscove NN, Wells RA. EAR-2: Identification of a Gene Involved in Maintenance of Clonogenicity in Haematopoiesis. Blood. 104: 3226-3226. DOI: 10.1182/Blood.V104.11.3226.3226 |
0.358 |
|
| 2004 |
Disperati P, Suarez-Saiz F, Gronda M, Minden MD, Schimmer A. Silencing of Caspase 8 Expression in Leukemia Cells and Patient Samples. Blood. 104: 2050-2050. DOI: 10.1182/Blood.V104.11.2050.2050 |
0.475 |
|
| 2003 |
Suh WS, Kim YS, Schimmer AD, Kitada S, Minden M, Andreeff M, Suh N, Sporn M, Reed JC. Synthetic triterpenoids activate a pathway for apoptosis in AML cells involving downregulation of FLIP and sensitization to TRAIL Leukemia. 17: 2122-2129. PMID 12931220 DOI: 10.1038/Sj.Leu.2403112 |
0.345 |
|
| 2002 |
Pedersen IM, Kitada S, Schimmer A, Kim Y, Zapata JM, Charboneau L, Rassenti L, Andreeff M, Bennett F, Sporn MB, Liotta LD, Kipps TJ, Reed JC. The triterpenoid CDDO induces apoptosis in refractory CLL B cells. Blood. 100: 2965-72. PMID 12351409 DOI: 10.1182/Blood-2002-04-1174 |
0.456 |
|
| 2001 |
Schimmer AD, Hedley DW, Pham NA, Chow S, Minden MD. BAD induces apoptosis in cells over-expressing Bcl-2 of Bcl-xL without loss of mitochondrial membrane potential Leukemia and Lymphoma. 42: 429-443. PMID 11699408 |
0.38 |
|
| 1989 |
Gerst JE, Benezra M, Schimmer A, Salomon Y. Phorbol ester impairs melanotropin receptor function and stimulates growth of cultured M2R melanoma cells European Journal of Pharmacology: Molecular Pharmacology. 172: 29-39. PMID 2540997 DOI: 10.1016/0922-4106(89)90042-4 |
0.4 |
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