Eric Lander, Ph.D. - Publications

Affiliations: 
1986-2004 Whitehead Institute, Cambridge, MA, United States 
 2004- Broad Institute, Cambridge, MA, United States 
Area:
Human genome
Website:
https://biology.mit.edu/people/eric_lander#overview

269 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Dvela-Levitt M, Kost-Alimova M, Emani M, Kohnert E, Thompson R, Sidhom EH, Rivadeneira A, Sahakian N, Roignot J, Papagregoriou G, Montesinos MS, Clark AR, McKinney D, Gutierrez J, Roth M, ... ... Lander ES, et al. Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy. Cell. 178: 521-535.e23. PMID 31348885 DOI: 10.1016/j.cell.2019.07.002  0.32
2018 Natarajan P, Peloso GM, Zekavat SM, Montasser M, Ganna A, Chaffin M, Khera AV, Zhou W, Bloom JM, Engreitz JM, Ernst J, O'Connell JR, Ruotsalainen SE, Alver M, Manichaikul A, ... ... Lander ES, et al. Deep-coverage whole genome sequences and blood lipids among 16,324 individuals. Nature Communications. 9: 3391. PMID 30140000 DOI: 10.1038/s41467-018-05747-8  0.44
2018 Tewhey R, Kotliar D, Park DS, Liu B, Winnicki S, Reilly SK, Andersen KG, Mikkelsen TS, Lander ES, Schaffner SF, Sabeti PC. Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay. Cell. 172: 1132-1134. PMID 29474912 DOI: 10.1016/j.cell.2018.02.021  0.32
2018 Flannick J, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, ... ... Lander ES, et al. Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data. 5: 180002. PMID 29360107 DOI: 10.1038/sdata.2018.2  0.52
2017 Jason F, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, ... ... Lander ES, et al. Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data. 4: 170179. PMID 29257133 DOI: 10.1038/sdata.2017.179  0.36
2017 Rao SSP, Huang SC, Glenn St Hilaire B, Engreitz JM, Perez EM, Kieffer-Kwon KR, Sanborn AL, Johnstone SE, Bascom GD, Bochkov ID, Huang X, Shamim MS, Shin J, Turner D, Ye Z, ... ... Lander ES, et al. Cohesin Loss Eliminates All Loop Domains. Cell. 171: 305-320.e24. PMID 28985562 DOI: 10.1016/j.cell.2017.09.026  0.32
2017 Saleheen D, Natarajan P, Armean IM, Zhao W, Rasheed A, Khetarpal SA, Won HH, Karczewski KJ, O'Donnell-Luria AH, Samocha KE, Weisburd B, Gupta N, Zaidi M, Samuel M, Imran A, ... ... Lander ES, et al. Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity. Nature. 544: 235-239. PMID 28406212 DOI: 10.1038/nature22034  0.52
2017 Grossman SR, Zhang X, Wang L, Engreitz J, Melnikov A, Rogov P, Tewhey R, Isakova A, Deplancke B, Bernstein BE, Mikkelsen TS, Lander ES. Systematic dissection of genomic features determining transcription factor binding and enhancer function. Proceedings of the National Academy of Sciences of the United States of America. PMID 28137873 DOI: 10.1073/pnas.1621150114  0.32
2016 Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, Ma C, Fontanillas P, Moutsianas L, McCarthy DJ, Rivas MA, Perry JR, Sim X, Blackwell TW, Robertson NR, ... ... Lander ES, et al. The genetic architecture of type 2 diabetes. Nature. PMID 27398621 DOI: 10.1038/nature18642  0.36
2016 Tewhey R, Kotliar D, Park DS, Liu B, Winnicki S, Reilly SK, Andersen KG, Mikkelsen TS, Lander ES, Schaffner SF, Sabeti PC. Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay. Cell. 165: 1519-1529. PMID 27259153 DOI: 10.1016/j.cell.2016.04.027  0.32
2016 Abudayyeh OO, Gootenberg JS, Konermann S, Joung J, Slaymaker IM, Cox DB, Shmakov S, Makarova KS, Semenova E, Minakhin L, Severinov K, Regev A, Lander ES, Koonin EV, Zhang F. C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector. Science (New York, N.Y.). PMID 27256883 DOI: 10.1126/science.aaf5573  0.96
2016 Blumenstiel B, DeFelice M, Birsoy O, Bleyer AJ, Kmoch S, Carter TA, Gnirke A, Kidd K, Rehm HL, Ronco L, Lander ES, Gabriel S, Lennon NJ. Development and Validation of a Mass Spectrometry-Based Assay for the Molecular Diagnosis of Mucin-1 Kidney Disease. The Journal of Molecular Diagnostics : Jmd. PMID 27157321 DOI: 10.1016/j.jmoldx.2016.03.003  0.32
2016 Giannakis M, Mu XJ, Shukla SA, Qian ZR, Cohen O, Nishihara R, Bahl S, Cao Y, Amin-Mansour A, Yamauchi M, Sukawa Y, Stewart C, Rosenberg M, Mima K, Inamura K, ... ... Lander ES, et al. Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma. Cell Reports. PMID 27149842 DOI: 10.1016/j.celrep.2016.03.075  0.96
2016 Wang T, Lander ES, Sabatini DM. Large-Scale Single Guide RNA Library Construction and Use for CRISPR-Cas9-Based Genetic Screens. Cold Spring Harbor Protocols. 2016: pdb.top086892. PMID 26933254 DOI: 10.1101/pdb.top086892  0.96
2016 Wang T, Lander ES, Sabatini DM. Viral Packaging and Cell Culture for CRISPR-Based Screens. Cold Spring Harbor Protocols. 2016: pdb.prot090811. PMID 26933250 DOI: 10.1101/pdb.prot090811  0.96
2016 Wang T, Lander ES, Sabatini DM. Single Guide RNA Library Design and Construction. Cold Spring Harbor Protocols. 2016: pdb.prot090803. PMID 26933249 DOI: 10.1101/pdb.prot090803  0.96
2016 Yassour M, Lim MY, Yun HS, Tickle TL, Sung J, Song YM, Lee K, Franzosa EA, Morgan XC, Gevers D, Lander ES, Xavier RJ, Birren BW, Ko G, Huttenhower C. Sub-clinical detection of gut microbial biomarkers of obesity and type 2 diabetes. Genome Medicine. 8: 17. PMID 26884067 DOI: 10.1186/s13073-016-0271-6  0.32
2016 Lander ES. The Heroes of CRISPR. Cell. 164: 18-28. PMID 26771483 DOI: 10.1016/j.cell.2015.12.041  0.96
2015 Sanborn AL, Rao SS, Huang SC, Durand NC, Huntley MH, Jewett AI, Bochkov ID, Chinnappan D, Cutkosky A, Li J, Geeting KP, Gnirke A, Melnikov A, McKenna D, Stamenova EK, ... Lander ES, et al. Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes. Proceedings of the National Academy of Sciences of the United States of America. PMID 26499245 DOI: 10.1073/pnas.1518552112  0.96
2015 Wang T, Birsoy K, Hughes NW, Krupczak KM, Post Y, Wei JJ, Lander ES, Sabatini DM. Identification and characterization of essential genes in the human genome. Science (New York, N.Y.). PMID 26472758 DOI: 10.1126/science.aac7041  0.96
2015 Golan D, Rosset S, Lander ES. Reply to Lee: Downward bias in heritability estimation is not due to simplified linkage equilibrium SNP simulation. Proceedings of the National Academy of Sciences of the United States of America. 112: E5452-3. PMID 26417112 DOI: 10.1073/pnas.1511370112  0.96
2015 Kamburov A, Lawrence MS, Polak P, Leshchiner I, Lage K, Golub TR, Lander ES, Getz G. Comprehensive assessment of cancer missense mutation clustering in protein structures. Proceedings of the National Academy of Sciences of the United States of America. 112: E5486-95. PMID 26392535 DOI: 10.1073/pnas.1516373112  0.96
2015 Andersen KG, Shapiro BJ, Matranga CB, Sealfon R, Lin AE, Moses LM, Folarin OA, Goba A, Odia I, Ehiane PE, Momoh M, England EM, Winnicki S, Branco LM, Gire SK, ... ... Lander ES, et al. Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus. Cell. 162: 738-50. PMID 26276630 DOI: 10.1016/j.cell.2015.07.020  0.44
2015 Cacchiarelli D, Trapnell C, Ziller MJ, Soumillon M, Cesana M, Karnik R, Donaghey J, Smith ZD, Ratanasirintrawoot S, Zhang X, Ho Sui SJ, Wu Z, Akopian V, Gifford CA, Doench J, ... ... Lander ES, et al. Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency. Cell. 162: 412-424. PMID 26186193 DOI: 10.1016/j.cell.2015.06.016  0.32
2015 Tonomura N, Elvers I, Thomas R, Megquier K, Turner-Maier J, Howald C, Sarver AL, Swofford R, Frantz AM, Ito D, Mauceli E, Arendt M, Noh HJ, Koltookian M, Biagi T, ... ... Lander ES, et al. Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers. Plos Genetics. 11: e1004922. PMID 25642983 DOI: 10.1371/journal.pgen.1004922  0.32
2015 Andersen KG, Shapiro BJ, Matranga CB, Sealfon R, Lin AE, Moses LM, Folarin OA, Goba A, Odia I, Ehiane PE, Momoh M, England EM, Winnicki S, Branco LM, Gire SK, ... ... Lander ES, et al. Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus Cell. 162: 738-750. DOI: 10.1016/j.cell.2015.07.020  0.44
2014 Delaneau O, Marchini J. Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel. Nature Communications. 5: 3934. PMID 25653097 DOI: 10.1038/ncomms4934  0.52
2014 Landau DA, Clement K, Ziller MJ, Boyle P, Fan J, Gu H, Stevenson K, Sougnez C, Wang L, Li S, Kotliar D, Zhang W, Ghandi M, Garraway L, Fernandes SM, ... ... Lander ES, et al. Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia. Cancer Cell. 26: 813-25. PMID 25490447 DOI: 10.1016/j.ccell.2014.10.012  0.32
2014 Gire SK, Goba A, Andersen KG, Sealfon RS, Park DJ, Kanneh L, Jalloh S, Momoh M, Fullah M, Dudas G, Wohl S, Moses LM, Yozwiak NL, Winnicki S, Matranga CB, ... ... Lander ES, et al. Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak. Science (New York, N.Y.). 345: 1369-72. PMID 25214632 DOI: 10.1126/science.1259657  0.32
2014 Brawand D, Wagner CE, Li YI, Malinsky M, Keller I, Fan S, Simakov O, Ng AY, Lim ZW, Bezault E, Turner-Maier J, Johnson J, Alcazar R, Noh HJ, Russell P, ... ... Lander ES, et al. The genomic substrate for adaptive radiation in African cichlid fish. Nature. 513: 375-81. PMID 25186727 DOI: 10.1038/nature13726  0.32
2014 Carneiro M, Rubin CJ, Di Palma F, Albert FW, Alföldi J, Barrio AM, Pielberg G, Rafati N, Sayyab S, Turner-Maier J, Younis S, Afonso S, Aken B, Alves JM, Barrell D, ... ... Lander ES, et al. Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication. Science (New York, N.Y.). 345: 1074-9. PMID 25170157 DOI: 10.1126/science.1253714  0.32
2014 Schwartz S, Mumbach MR, Jovanovic M, Wang T, Maciag K, Bushkin GG, Mertins P, Ter-Ovanesyan D, Habib N, Cacchiarelli D, Sanjana NE, Freinkman E, Pacold ME, Satija R, Mikkelsen TS, ... ... Lander ES, et al. Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Reports. 8: 284-96. PMID 24981863 DOI: 10.1016/j.celrep.2014.05.048  0.32
2014 Hoeppner MP, Lundquist A, Pirun M, Meadows JR, Zamani N, Johnson J, Sundström G, Cook A, FitzGerald MG, Swofford R, Mauceli E, Moghadam BT, Greka A, Alföldi J, Abouelleil A, ... ... Lander ES, et al. An improved canine genome and a comprehensive catalogue of coding genes and non-coding transcripts. Plos One. 9: e91172. PMID 24625832 DOI: 10.1371/journal.pone.0091172  0.32
2014 Zuk O, Schaffner SF, Samocha K, Do R, Hechter E, Kathiresan S, Daly MJ, Neale BM, Sunyaev SR, Lander ES. Searching for missing heritability: designing rare variant association studies. Proceedings of the National Academy of Sciences of the United States of America. 111: E455-64. PMID 24443550 DOI: 10.1073/pnas.1322563111  0.52
2013 Karlsson EK, Sigurdsson S, Ivansson E, Thomas R, Elvers I, Wright J, Howald C, Tonomura N, Perloski M, Swofford R, Biagi T, Fryc S, Anderson N, Courtay-Cahen C, Youell L, ... ... Lander ES, et al. Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. Genome Biology. 14: R132. PMID 24330828 DOI: 10.1186/gb-2013-14-12-r132  0.32
2013 Schwartz S, Agarwala SD, Mumbach MR, Jovanovic M, Mertins P, Shishkin A, Tabach Y, Mikkelsen TS, Satija R, Ruvkun G, Carr SA, Lander ES, Fink GR, Regev A. High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Cell. 155: 1409-21. PMID 24269006 DOI: 10.1016/j.cell.2013.10.047  0.96
2013 Farhat MR, Shapiro BJ, Kieser KJ, Sultana R, Jacobson KR, Victor TC, Warren RM, Streicher EM, Calver A, Sloutsky A, Kaur D, Posey JE, Plikaytis B, Oggioni MR, Gardy JL, ... ... Lander ES, et al. Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis. Nature Genetics. 45: 1183-9. PMID 23995135 DOI: 10.1038/ng.2747  0.44
2013 Engreitz JM, Pandya-Jones A, McDonel P, Shishkin A, Sirokman K, Surka C, Kadri S, Xing J, Goren A, Lander ES, Plath K, Guttman M. The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome. Science (New York, N.Y.). 341: 1237973. PMID 23828888 DOI: 10.1126/science.1237973  0.96
2013 Guttman M, Russell P, Ingolia NT, Weissman JS, Lander ES. Ribosome profiling provides evidence that large noncoding RNAs do not encode proteins. Cell. 154: 240-51. PMID 23810193 DOI: 10.1016/j.cell.2013.06.009  0.96
2013 Gifford CA, Ziller MJ, Gu H, Trapnell C, Donaghey J, Tsankov A, Shalek AK, Kelley DR, Shishkin AA, Issner R, Zhang X, Coyne M, Fostel JL, Holmes L, Meldrim J, ... ... Lander ES, et al. Transcriptional and epigenetic dynamics during specification of human embryonic stem cells. Cell. 153: 1149-63. PMID 23664763 DOI: 10.1016/j.cell.2013.04.037  0.32
2013 Amemiya CT, Alföldi J, Lee AP, Fan S, Philippe H, Maccallum I, Braasch I, Manousaki T, Schneider I, Rohner N, Organ C, Chalopin D, Smith JJ, Robinson M, Dorrington RA, ... ... Lander ES, et al. The African coelacanth genome provides insights into tetrapod evolution. Nature. 496: 311-6. PMID 23598338 DOI: 10.1038/nature12027  0.32
2013 Garraway LA, Lander ES. Lessons from the cancer genome. Cell. 153: 17-37. PMID 23540688 DOI: 10.1016/j.cell.2013.03.002  0.96
2013 Kirby A, Gnirke A, Jaffe DB, Barešová V, Pochet N, Blumenstiel B, Ye C, Aird D, Stevens C, Robinson JT, Cabili MN, Gat-Viks I, Kelliher E, Daza R, DeFelice M, ... ... Lander ES, et al. Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing. Nature Genetics. 45: 299-303. PMID 23396133 DOI: 10.1038/ng.2543  0.52
2013 Drier Y, Lawrence MS, Carter SL, Stewart C, Gabriel SB, Lander ES, Meyerson M, Beroukhim R, Getz G. Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability. Genome Research. 23: 228-35. PMID 23124520 DOI: 10.1101/gr.141382.112  0.96
2012 Grad YH, Lipsitch M, Griggs AD, Haas BJ, Shea TP, McCowan C, Montmayeur A, FitzGerald M, Wortman JR, Krogfelt KA, Bingen E, Weill FX, Tietze E, Flieger A, Lander ES, et al. Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany. Proceedings of the National Academy of Sciences of the United States of America. 109: E3629-30. PMID 23479789 DOI: 10.1073/pnas.1209419110  0.96
2012 Sankaran VG, Ghazvinian R, Do R, Thiru P, Vergilio JA, Beggs AH, Sieff CA, Orkin SH, Nathan DG, Lander ES, Gazda HT. Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia. The Journal of Clinical Investigation. 122: 2439-43. PMID 22706301 DOI: 10.1172/JCI63597  0.96
2012 Jones FC, Grabherr MG, Chan YF, Russell P, Mauceli E, Johnson J, Swofford R, Pirun M, Zody MC, White S, Birney E, Searle S, Schmutz J, Grimwood J, Dickson MC, ... ... Lander ES, et al. The genomic basis of adaptive evolution in threespine sticklebacks. Nature. 484: 55-61. PMID 22481358 DOI: 10.1038/nature10944  0.32
2012 Onder TT, Kara N, Cherry A, Sinha AU, Zhu N, Bernt KM, Cahan P, Marcarci BO, Unternaehrer J, Gupta PB, Lander ES, Armstrong SA, Daley GQ. Chromatin-modifying enzymes as modulators of reprogramming. Nature. 483: 598-602. PMID 22388813 DOI: 10.1038/nature10953  0.96
2012 Melnikov A, Murugan A, Zhang X, Tesileanu T, Wang L, Rogov P, Feizi S, Gnirke A, Callan CG, Kinney JB, Kellis M, Lander ES, Mikkelsen TS. Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay. Nature Biotechnology. 30: 271-7. PMID 22371084 DOI: 10.1038/nbt.2137  0.44
2012 Grad YH, Lipsitch M, Feldgarden M, Arachchi HM, Cerqueira GC, Fitzgerald M, Godfrey P, Haas BJ, Murphy CI, Russ C, Sykes S, Walker BJ, Wortman JR, Young S, Zeng Q, ... ... Lander ES, et al. Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011. Proceedings of the National Academy of Sciences of the United States of America. 109: 3065-70. PMID 22315421 DOI: 10.1073/pnas.1121491109  0.32
2012 Zuk O, Hechter E, Sunyaev SR, Lander ES. The mystery of missing heritability: Genetic interactions create phantom heritability. Proceedings of the National Academy of Sciences of the United States of America. 109: 1193-8. PMID 22223662 DOI: 10.1073/pnas.1119675109  0.96
2012 Grad YH, Lipsitch M, Feldgarden M, Arachchi HM, Cerqueira GC, FitzGerald M, Godfrey P, Haas BJ, Murphy CI, Russ C, Sykes S, Walker BJ, Wortman JR, Young S, Zeng Q, ... ... Lander ES, et al. Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011 (Proceedings of the National Academy of Sciences of the United States of America (2012) 109, 8, (3065-3070) doi:10.1073/pnas.1121491109) Proceedings of the National Academy of Sciences of the United States of America. 109: 5547. DOI: 10.1073/pnas.1203955109  0.32
2011 Reshef DN, Reshef YA, Finucane HK, Grossman SR, McVean G, Turnbaugh PJ, Lander ES, Mitzenmacher M, Sabeti PC. Detecting novel associations in large data sets. Science (New York, N.Y.). 334: 1518-24. PMID 22174245 DOI: 10.1126/science.1205438  0.96
2011 Lindblad-Toh K, Garber M, Zuk O, Lin MF, Parker BJ, Washietl S, Kheradpour P, Ernst J, Jordan G, Mauceli E, Ward LD, Lowe CB, Holloway AK, Clamp M, Gnerre S, ... ... Lander ES, et al. A high-resolution map of human evolutionary constraint using 29 mammals. Nature. 478: 476-82. PMID 21993624 DOI: 10.1038/nature10530  0.96
2011 Bass AJ, Lawrence MS, Brace LE, Ramos AH, Drier Y, Cibulskis K, Sougnez C, Voet D, Saksena G, Sivachenko A, Jing R, Parkin M, Pugh T, Verhaak RG, Stransky N, ... ... Lander ES, et al. Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. Nature Genetics. 43: 964-8. PMID 21892161 DOI: 10.1038/ng.936  0.96
2011 Alföldi J, Di Palma F, Grabherr M, Williams C, Kong L, Mauceli E, Russell P, Lowe CB, Glor RE, Jaffe JD, Ray DA, Boissinot S, Shedlock AM, Botka C, Castoe TA, ... ... Lander ES, et al. The genome of the green anole lizard and a comparative analysis with birds and mammals. Nature. 477: 587-91. PMID 21881562 DOI: 10.1038/nature10390  0.96
2011 Guttman M, Donaghey J, Carey BW, Garber M, Grenier JK, Munson G, Young G, Lucas AB, Ach R, Bruhn L, Yang X, Amit I, Meissner A, Regev A, Rinn JL, ... ... Lander ES, et al. lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature. 477: 295-300. PMID 21874018 DOI: 10.1038/nature10398  0.96
2011 Gupta PB, Fillmore CM, Jiang G, Shapira SD, Tao K, Kuperwasser C, Lander ES. Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell. 146: 633-44. PMID 21854987 DOI: 10.1016/j.cell.2011.07.026  0.96
2011 Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, Kryukov GV, Lawrence MS, Sougnez C, McKenna A, Shefler E, Ramos AH, Stojanov P, Carter SL, Voet D, ... ... Lander ES, et al. The mutational landscape of head and neck squamous cell carcinoma. Science (New York, N.Y.). 333: 1157-60. PMID 21798893 DOI: 10.1126/science.1208130  0.96
2011 Cheung HW, Cowley GS, Weir BA, Boehm JS, Rusin S, Scott JA, East A, Ali LD, Lizotte PH, Wong TC, Jiang G, Hsiao J, Mermel CH, Getz G, Barretina J, ... ... Lander ES, et al. Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. Proceedings of the National Academy of Sciences of the United States of America. 108: 12372-7. PMID 21746896 DOI: 10.1073/pnas.1109363108  0.96
2011 Bell D, Berchuck A, Birrer M, Chien J, Cramer DW, Dao F, Dhir R, Disaia P, Gabra H, Glenn P, Godwin AK, Gross J, Hartmann L, Huang M, Huntsman DG, ... ... Lander ES, et al. Integrated genomic analyses of ovarian carcinoma Nature. 474: 609-615. PMID 21720365 DOI: 10.1038/nature10166  0.96
2011 Van Tyne D, Park DJ, Schaffner SF, Neafsey DE, Angelino E, Cortese JF, Barnes KG, Rosen DM, Lukens AK, Daniels RF, Milner DA, Johnson CA, Shlyakhter I, Grossman SR, Becker JS, ... ... Lander ES, et al. Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum. Plos Genetics. 7: e1001383. PMID 21533027 DOI: 10.1371/journal.pgen.1001383  0.96
2011 Chapman MA, Lawrence MS, Keats JJ, Cibulskis K, Sougnez C, Schinzel AC, Harview CL, Brunet JP, Ahmann GJ, Adli M, Anderson KC, Ardlie KG, Auclair D, Baker A, Bergsagel PL, ... ... Lander ES, et al. Initial genome sequencing and analysis of multiple myeloma. Nature. 471: 467-72. PMID 21430775 DOI: 10.1038/nature09837  0.96
2011 Lander ES. Genome-sequencing anniversary. The accelerator. Science (New York, N.Y.). 331: 1024. PMID 21350161 DOI: 10.1126/science.1204037  0.96
2011 Berger MF, Lawrence MS, Demichelis F, Drier Y, Cibulskis K, Sivachenko AY, Sboner A, Esgueva R, Pflueger D, Sougnez C, Onofrio R, Carter SL, Park K, Habegger L, Ambrogio L, ... ... Lander ES, et al. The genomic complexity of primary human prostate cancer. Nature. 470: 214-20. PMID 21307934 DOI: 10.1038/nature09744  0.96
2011 Lander ES. Initial impact of the sequencing of the human genome. Nature. 470: 187-97. PMID 21307931 DOI: 10.1038/nature09792  0.96
2011 Proia TA, Keller PJ, Gupta PB, Klebba I, Jones AD, Sedic M, Gilmore H, Tung N, Naber SP, Schnitt S, Lander ES, Kuperwasser C. Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate. Cell Stem Cell. 8: 149-63. PMID 21295272 DOI: 10.1016/j.stem.2010.12.007  0.96
2011 Robinson JT, Thorvaldsdóttir H, Winckler W, Guttman M, Lander ES, Getz G, Mesirov JP. Integrative genomics viewer. Nature Biotechnology. 29: 24-6. PMID 21221095 DOI: 10.1038/nbt.1754  0.96
2011 Sankaran VG, Menne TF, Šćepanović D, Vergilio JA, Ji P, Kim J, Thiru P, Orkin SH, Lander ES, Lodish HF. MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Proceedings of the National Academy of Sciences of the United States of America. 108: 1519-24. PMID 21205891 DOI: 10.1073/pnas.1018384108  0.96
2011 Gnerre S, Maccallum I, Przybylski D, Ribeiro FJ, Burton JN, Walker BJ, Sharpe T, Hall G, Shea TP, Sykes S, Berlin AM, Aird D, Costello M, Daza R, Williams L, ... ... Lander ES, et al. High-quality draft assemblies of mammalian genomes from massively parallel sequence data. Proceedings of the National Academy of Sciences of the United States of America. 108: 1513-8. PMID 21187386 DOI: 10.1073/pnas.1017351108  0.96
2010 Fillmore CM, Gupta PB, Rudnick JA, Caballero S, Keller PJ, Lander ES, Kuperwasser C. Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling. Proceedings of the National Academy of Sciences of the United States of America. 107: 21737-42. PMID 21098263 DOI: 10.1073/pnas.1007863107  0.96
2010 Loewer S, Cabili MN, Guttman M, Loh YH, Thomas K, Park IH, Garber M, Curran M, Onder T, Agarwal S, Manos PD, Datta S, Lander ES, Schlaeger TM, Daley GQ, et al. Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells. Nature Genetics. 42: 1113-7. PMID 21057500 DOI: 10.1038/ng.710  0.96
2010 Abecasis GR, Altshuler D, Auton A, Brooks LD, Durbin RM, Gibbs RA, Hurles ME, McVean GA. A map of human genome variation from population-scale sequencing. Nature. 467: 1061-73. PMID 20981092 DOI: 10.1038/nature09534  0.96
2010 Neafsey DE, Lawniczak MK, Park DJ, Redmond SN, Coulibaly MB, Traoré SF, Sagnon N, Costantini C, Johnson C, Wiegand RC, Collins FH, Lander ES, Wirth DF, Kafatos FC, Besansky NJ, et al. SNP genotyping defines complex gene-flow boundaries among African malaria vector mosquitoes. Science (New York, N.Y.). 330: 514-7. PMID 20966254 DOI: 10.1126/science.1193036  0.96
2010 Bernstein BE, Stamatoyannopoulos JA, Costello JF, Ren B, Milosavljevic A, Meissner A, Kellis M, Marra MA, Beaudet AL, Ecker JR, Farnham PJ, Hirst M, Lander ES, Mikkelsen TS, Thomson JA. The NIH Roadmap Epigenomics Mapping Consortium. Nature Biotechnology. 28: 1045-8. PMID 20944595 DOI: 10.1038/nbt1010-1045  0.96
2010 Lander ES, Gates SJ. Prepare and inspire. Science (New York, N.Y.). 330: 151. PMID 20929738 DOI: 10.1126/science.1198062  0.96
2010 Mikkelsen TS, Xu Z, Zhang X, Wang L, Gimble JM, Lander ES, Rosen ED. Comparative epigenomic analysis of murine and human adipogenesis. Cell. 143: 156-69. PMID 20887899 DOI: 10.1016/j.cell.2010.09.006  0.96
2010 Taube JH, Herschkowitz JI, Komurov K, Zhou AY, Gupta S, Yang J, Hartwell K, Onder TT, Gupta PB, Evans KW, Hollier BG, Ram PT, Lander ES, Rosen JM, Weinberg RA, et al. Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proceedings of the National Academy of Sciences of the United States of America. 107: 15449-54. PMID 20713713 DOI: 10.1073/pnas.1004900107  0.96
2010 Huarte M, Guttman M, Feldser D, Garber M, Koziol MJ, Kenzelmann-Broz D, Khalil AM, Zuk O, Amit I, Rabani M, Attardi LD, Regev A, Lander ES, Jacks T, Rinn JL. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell. 142: 409-19. PMID 20673990 DOI: 10.1016/j.cell.2010.06.040  0.96
2010 Barretina J, Taylor BS, Banerji S, Ramos AH, Lagos-Quintana M, Decarolis PL, Shah K, Socci ND, Weir BA, Ho A, Chiang DY, Reva B, Mermel CH, Getz G, Antipin Y, ... ... Lander ES, et al. Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nature Genetics. 42: 715-21. PMID 20601955 DOI: 10.1038/ng.619  0.96
2010 Aiden AP, Rivera MN, Rheinbay E, Ku M, Coffman EJ, Truong TT, Vargas SO, Lander ES, Haber DA, Bernstein BE. Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network. Cell Stem Cell. 6: 591-602. PMID 20569696 DOI: 10.1016/j.stem.2010.03.016  0.96
2010 van Berkum NL, Lieberman-Aiden E, Williams L, Imakaev M, Gnirke A, Mirny LA, Dekker J, Lander ES. Hi-C: a method to study the three-dimensional architecture of genomes. Journal of Visualized Experiments : Jove. PMID 20461051 DOI: 10.3791/1869  0.32
2010 Green RE, Krause J, Briggs AW, Maricic T, Stenzel U, Kircher M, Patterson N, Li H, Zhai W, Fritz MH, Hansen NF, Durand EY, Malaspinas AS, Jensen JD, Marques-Bonet T, ... ... Lander ES, et al. A draft sequence of the Neandertal genome. Science (New York, N.Y.). 328: 710-22. PMID 20448178 DOI: 10.1126/science.1188021  0.96
2010 Guttman M, Garber M, Levin JZ, Donaghey J, Robinson J, Adiconis X, Fan L, Koziol MJ, Gnirke A, Nusbaum C, Rinn JL, Lander ES, Regev A. Ab initio reconstruction of cell type-specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs. Nature Biotechnology. 28: 503-10. PMID 20436462 DOI: 10.1038/nbt.1633  0.96
2010 Berger MF, Levin JZ, Vijayendran K, Sivachenko A, Adiconis X, Maguire J, Johnson LA, Robinson J, Verhaak RG, Sougnez C, Onofrio RC, Ziaugra L, Cibulskis K, Laine E, Barretina J, ... ... Lander ES, et al. Integrative analysis of the melanoma transcriptome. Genome Research. 20: 413-27. PMID 20179022 DOI: 10.1101/gr.103697.109  0.96
2010 Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, Barretina J, Boehm JS, Dobson J, Urashima M, Mc Henry KT, Pinchback RM, Ligon AH, Cho YJ, Haery L, ... ... Lander ES, et al. The landscape of somatic copy-number alteration across human cancers. Nature. 463: 899-905. PMID 20164920 DOI: 10.1038/nature08822  0.96
2010 Burrage LC, Baskin-Hill AE, Sinasac DS, Singer JB, Croniger CM, Kirby A, Kulbokas EJ, Daly MJ, Lander ES, Broman KW, Nadeau JH. Genetic resistance to diet-induced obesity in chromosome substitution strains of mice. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 21: 115-29. PMID 20127486 DOI: 10.1007/s00335-010-9247-9  0.96
2010 Kim SY, Dunn IF, Firestein R, Gupta P, Wardwell L, Repich K, Schinzel AC, Wittner B, Silver SJ, Root DE, Boehm JS, Ramaswamy S, Lander ES, Hahn WC. CK1epsilon is required for breast cancers dependent on beta-catenin activity. Plos One. 5: e8979. PMID 20126544 DOI: 10.1371/journal.pone.0008979  0.96
2010 Gu H, Bock C, Mikkelsen TS, Jäger N, Smith ZD, Tomazou E, Gnirke A, Lander ES, Meissner A. Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution. Nature Methods. 7: 133-6. PMID 20062050 DOI: 10.1038/nmeth.1414  0.96
2010 Grossman SR, Shlyakhter I, Shylakhter I, Karlsson EK, Byrne EH, Morales S, Frieden G, Hostetter E, Angelino E, Garber M, Zuk O, Lander ES, Schaffner SF, Sabeti PC. A composite of multiple signals distinguishes causal variants in regions of positive selection. Science (New York, N.Y.). 327: 883-6. PMID 20056855 DOI: 10.1126/science.1183863  0.96
2009 Markljung E, Jiang L, Jaffe JD, Mikkelsen TS, Wallerman O, Larhammar M, Zhang X, Wang L, Saenz-Vash V, Gnirke A, Lindroth AM, Barrés R, Yan J, Strömberg S, De S, ... ... Lander ES, et al. ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth. Plos Biology. 7: e1000256. PMID 20016685 DOI: 10.1371/journal.pbio.1000256  0.96
2009 Wade CM, Giulotto E, Sigurdsson S, Zoli M, Gnerre S, Imsland F, Lear TL, Adelson DL, Bailey E, Bellone RR, Blöcker H, Distl O, Edgar RC, Garber M, Leeb T, ... ... Lander ES, et al. Genome sequence, comparative analysis, and population genetics of the domestic horse. Science (New York, N.Y.). 326: 865-7. PMID 19892987 DOI: 10.1126/science.1178158  0.96
2009 Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P, Meylan E, Scholl C, Fröhling S, Chan EM, Sos ML, Michel K, Mermel C, ... ... Lander ES, et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature. 462: 108-12. PMID 19847166 DOI: 10.1038/nature08460  0.96
2009 Lander E, Jiang G, Tao K. Taking aim at aggressive cancer cells. Cancer Biology & Therapy. 8: ii. PMID 19830887  0.96
2009 Lieberman-Aiden E, van Berkum NL, Williams L, Imakaev M, Ragoczy T, Telling A, Amit I, Lajoie BR, Sabo PJ, Dorschner MO, Sandstrom R, Bernstein B, Bender MA, Groudine M, Gnirke A, ... ... Lander ES, et al. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science (New York, N.Y.). 326: 289-93. PMID 19815776 DOI: 10.1126/science.1181369  0.96
2009 Gnerre S, Lander ES, Lindblad-Toh K, Jaffe DB. Assisted assembly: how to improve a de novo genome assembly by using related species. Genome Biology. 10: R88. PMID 19712469 DOI: 10.1186/gb-2009-10-8-r88  0.96
2009 Gupta PB, Onder TT, Jiang G, Tao K, Kuperwasser C, Weinberg RA, Lander ES. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 138: 645-59. PMID 19682730 DOI: 10.1016/j.cell.2009.06.034  0.96
2009 Vasudevan KM, Barbie DA, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, ... ... Lander ES, et al. AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell. 16: 21-32. PMID 19573809 DOI: 10.1016/j.ccr.2009.04.012  0.96
2009 Khalil AM, Guttman M, Huarte M, Garber M, Raj A, Rivea Morales D, Thomas K, Presser A, Bernstein BE, van Oudenaarden A, Regev A, Lander ES, Rinn JL. Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proceedings of the National Academy of Sciences of the United States of America. 106: 11667-72. PMID 19571010 DOI: 10.1073/pnas.0904715106  0.96
2009 Gnirke A, Melnikov A, Maguire J, Rogov P, LeProust EM, Brockman W, Fennell T, Giannoukos G, Fisher S, Russ C, Gabriel S, Jaffe DB, Lander ES, Nusbaum C. Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing. Nature Biotechnology. 27: 182-9. PMID 19182786 DOI: 10.1038/nbt.1523  0.96
2009 Guttman M, Amit I, Garber M, French C, Lin MF, Feldser D, Huarte M, Zuk O, Carey BW, Cassady JP, Cabili MN, Jaenisch R, Mikkelsen TS, Jacks T, Hacohen N, ... ... Lander ES, et al. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature. 458: 223-7. PMID 19182780 DOI: 10.1038/nature07672  0.96
2009 Nusbaum C, Ohsumi TK, Gomez J, Aquadro J, Victor TC, Warren RM, Hung DT, Birren BW, Lander ES, Jaffe DB. Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencing. Nature Methods. 6: 67-9. PMID 19079253 DOI: 10.1038/nmeth.1286  0.96
2009 Chiang DY, Getz G, Jaffe DB, O'Kelly MJ, Zhao X, Carter SL, Russ C, Nusbaum C, Meyerson M, Lander ES. High-resolution mapping of copy-number alterations with massively parallel sequencing. Nature Methods. 6: 99-103. PMID 19043412 DOI: 10.1038/nmeth.1276  0.96
2009 Lander ES, Green P, Abrahamson J, Barlow A, Daly MJ, Lincoln SE, Newberg LA. Corrigendum to "MAPMAKER: An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations" [Genomics 1 (1987) 174-181] (PII:0888-7543(87)90010-3) Genomics. 93: 398. DOI: 10.1016/j.ygeno.2008.12.003  0.96
2008 Luo B, Cheung HW, Subramanian A, Sharifnia T, Okamoto M, Yang X, Hinkle G, Boehm JS, Beroukhim R, Weir BA, Mermel C, Barbie DA, Awad T, Zhou X, Nguyen T, ... ... Lander ES, et al. Highly parallel identification of essential genes in cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 105: 20380-5. PMID 19091943 DOI: 10.1073/pnas.0810485105  0.96
2008 Neafsey DE, Schaffner SF, Volkman SK, Park D, Montgomery P, Milner DA, Lukens A, Rosen D, Daniels R, Houde N, Cortese JF, Tyndall E, Gates C, Stange-Thomann N, Sarr O, ... ... Lander ES, et al. Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence. Genome Biology. 9: R171. PMID 19077304 DOI: 10.1186/gb-2008-9-12-r171  0.96
2008 Shao H, Burrage LC, Sinasac DS, Hill AE, Ernest SR, O'Brien W, Courtland HW, Jepsen KJ, Kirby A, Kulbokas EJ, Daly MJ, Broman KW, Lander ES, Nadeau JH. Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis. Proceedings of the National Academy of Sciences of the United States of America. 105: 19910-4. PMID 19066216 DOI: 10.1073/pnas.0810388105  0.96
2008 Miller W, Drautz DI, Ratan A, Pusey B, Qi J, Lesk AM, Tomsho LP, Packard MD, Zhao F, Sher A, Tikhonov A, Raney B, Patterson N, Lindblad-Toh K, Lander ES, et al. Sequencing the nuclear genome of the extinct woolly mammoth. Nature. 456: 387-90. PMID 19020620 DOI: 10.1038/nature07446  0.96
2008 Altshuler D, Daly MJ, Lander ES. Genetic mapping in human disease. Science (New York, N.Y.). 322: 881-8. PMID 18988837 DOI: 10.1126/science.1156409  0.96
2008 Ku M, Koche RP, Rheinbay E, Mendenhall EM, Endoh M, Mikkelsen TS, Presser A, Nusbaum C, Xie X, Chi AS, Adli M, Kasif S, Ptaszek LM, Cowan CA, Lander ES, et al. Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. Plos Genetics. 4: e1000242. PMID 18974828 DOI: 10.1371/journal.pgen.1000242  0.96
2008 Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, Cibulskis K, Sougnez C, Greulich H, Muzny DM, Morgan MB, Fulton L, Fulton RS, Zhang Q, Wendl MC, Lawrence MS, ... ... Lander ES, et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature. 455: 1069-75. PMID 18948947 DOI: 10.1038/nature07423  0.96
2008 McLendon R, Friedman A, Bigner D, Van Meir EG, Brat DJ, Mastrogianakis GM, Olson JJ, Mikkelsen T, Lehman N, Aldape K, Yung WKA, Bogler O, Weinstein JN, VandenBerg S, Berger M, ... ... Lander ES, et al. Comprehensive genomic characterization defines human glioblastoma genes and core pathways Nature. 455: 1061-1068. PMID 18772890 DOI: 10.1038/nature07385  0.96
2008 Meissner A, Mikkelsen TS, Gu H, Wernig M, Hanna J, Sivachenko A, Zhang X, Bernstein BE, Nusbaum C, Jaffe DB, Gnirke A, Jaenisch R, Lander ES. Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature. 454: 766-70. PMID 18600261 DOI: 10.1038/nature07107  0.96
2008 Freeman RM, Wu M, Cordonnier-Pratt MM, Pratt LH, Gruber CE, Smith M, Lander ES, Stange-Thomann N, Lowe CJ, Gerhart J, Kirschner M. cDNA sequences for transcription factors and signaling proteins of the hemichordate Saccoglossus kowalevskii: efficacy of the expressed sequence tag (EST) approach for evolutionary and developmental studies of a new organism. The Biological Bulletin. 214: 284-302. PMID 18574105  0.96
2008 Mikkelsen TS, Hanna J, Zhang X, Ku M, Wernig M, Schorderet P, Bernstein BE, Jaenisch R, Lander ES, Meissner A. Dissecting direct reprogramming through integrative genomic analysis. Nature. 454: 49-55. PMID 18509334 DOI: 10.1038/nature07056  0.96
2008 Onder TT, Gupta PB, Mani SA, Yang J, Lander ES, Weinberg RA. Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Research. 68: 3645-54. PMID 18483246 DOI: 10.1158/0008-5472.CAN-07-2938  0.96
2008 Butler J, MacCallum I, Kleber M, Shlyakhter IA, Belmonte MK, Lander ES, Nusbaum C, Jaffe DB. ALLPATHS: de novo assembly of whole-genome shotgun microreads. Genome Research. 18: 810-20. PMID 18340039 DOI: 10.1101/gr.7337908  0.96
2008 Brockman W, Alvarez P, Young S, Garber M, Giannoukos G, Lee WL, Russ C, Lander ES, Nusbaum C, Jaffe DB. Quality scores and SNP detection in sequencing-by-synthesis systems. Genome Research. 18: 763-70. PMID 18212088 DOI: 10.1101/gr.070227.107  0.96
2008 Mikkelsen TS, Hanna J, Zhang X, Ku M, Wernig M, Schorderet P, Bernstein BE, Jaenisch R, Lander ES, Meissner A. Dissecting direct reprogramming through integrative genomic analysis (Nature (2008) 454, (49-55)) Nature. 454: 794. DOI: 10.1038/nature07196  0.96
2008 Patterson N, Richter DJ, Gnerre S, Lander ES, Reich D. Patterson et al. reply Nature. 452: E4. DOI: 10.1038/nature06806  0.96
2007 Beroukhim R, Getz G, Nghiemphu L, Barretina J, Hsueh T, Linhart D, Vivanco I, Lee JC, Huang JH, Alexander S, Du J, Kau T, Thomas RK, Shah K, Soto H, ... ... Lander ES, et al. Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma. Proceedings of the National Academy of Sciences of the United States of America. 104: 20007-12. PMID 18077431 DOI: 10.1073/pnas.0710052104  0.96
2007 Daily JP, Scanfeld D, Pochet N, Le Roch K, Plouffe D, Kamal M, Sarr O, Mboup S, Ndir O, Wypij D, Levasseur K, Thomas E, Tamayo P, Dong C, Zhou Y, ... Lander ES, et al. Distinct physiological states of Plasmodium falciparum in malaria-infected patients. Nature. 450: 1091-5. PMID 18046333 DOI: 10.1038/nature06311  0.96
2007 Clamp M, Fry B, Kamal M, Xie X, Cuff J, Lin MF, Kellis M, Lindblad-Toh K, Lander ES. Distinguishing protein-coding and noncoding genes in the human genome. Proceedings of the National Academy of Sciences of the United States of America. 104: 19428-33. PMID 18040051 DOI: 10.1073/pnas.0709013104  0.96
2007 Miller W, Rosenbloom K, Hardison RC, Hou M, Taylor J, Raney B, Burhans R, King DC, Baertsch R, Blankenberg D, Kosakovsky Pond SL, Nekrutenko A, Giardine B, Harris RS, Tyekucheva S, ... ... Lander ES, et al. 28-way vertebrate alignment and conservation track in the UCSC Genome Browser. Genome Research. 17: 1797-808. PMID 17984227 DOI: 10.1101/gr.6761107  0.96
2007 Weir BA, Woo MS, Getz G, Perner S, Ding L, Beroukhim R, Lin WM, Province MA, Kraja A, Johnson LA, Shah K, Sato M, Thomas RK, Barletta JA, Borecki IB, ... ... Lander ES, et al. Characterizing the cancer genome in lung adenocarcinoma. Nature. 450: 893-8. PMID 17982442 DOI: 10.1038/nature06358  0.96
2007 Sabeti PC, Varilly P, Fry B, Lohmueller J, Hostetter E, Cotsapas C, Xie X, Byrne EH, McCarroll SA, Gaudet R, Schaffner SF, Lander ES, Frazer KA, Ballinger DG, et al. Genome-wide detection and characterization of positive selection in human populations. Nature. 449: 913-8. PMID 17943131 DOI: 10.1038/nature06250  0.52
2007 Karlsson EK, Baranowska I, Wade CM, Salmon Hillbertz NH, Zody MC, Anderson N, Biagi TM, Patterson N, Pielberg GR, Kulbokas EJ, Comstock KE, Keller ET, Mesirov JP, von Euler H, Kämpe O, ... ... Lander ES, et al. Efficient mapping of mendelian traits in dogs through genome-wide association. Nature Genetics. 39: 1321-8. PMID 17906626 DOI: 10.1038/ng.2007.10  0.96
2007 Getz G, Höfling H, Mesirov JP, Golub TR, Meyerson M, Tibshirani R, Lander ES. Comment on "The consensus coding sequences of human breast and colorectal cancers". Science (New York, N.Y.). 317: 1500. PMID 17872428 DOI: 10.1126/science.1138764  0.96
2007 Manolio TA, Rodriguez LL, Brooks L, Abecasis G, Ballinger D, Daly M, Donnelly P, Faraone SV, Frazer K, Gabriel S, Gejman P, ... ... Lander E, et al. New models of collaboration in genome-wide association studies: the Genetic Association Information Network. Nature Genetics. 39: 1045-51. PMID 17728769 DOI: 10.1038/ng2127  0.96
2007 Hafler DA, Compston A, Sawcer S, Lander ES, Daly MJ, De Jager PL, de Bakker PI, Gabriel SB, Mirel DB, Ivinson AJ, Pericak-Vance MA, Gregory SG, Rioux JD, McCauley JL, et al. Risk alleles for multiple sclerosis identified by a genomewide study. The New England Journal of Medicine. 357: 851-62. PMID 17660530 DOI: 10.1056/NEJMoa073493  0.96
2007 Mikkelsen TS, Ku M, Jaffe DB, Issac B, Lieberman E, Giannoukos G, Alvarez P, Brockman W, Kim TK, Koche RP, Lee W, Mendenhall E, O'Donovan A, Presser A, Russ C, ... ... Lander ES, et al. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature. 448: 553-60. PMID 17603471 DOI: 10.1038/nature06008  0.96
2007 Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, Greulich H, Stewart CJ, Mulvey LA, Shen RR, Ambrogio L, ... ... Lander ES, et al. Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell. 129: 1065-79. PMID 17574021 DOI: 10.1016/j.cell.2007.03.052  0.96
2007 Margulies EH, Cooper GM, Asimenos G, Thomas DJ, Dewey CN, Siepel A, Birney E, Keefe D, Schwartz AS, Hou M, Taylor J, Nikolaev S, Montoya-Burgos JI, Löytynoja A, Whelan S, ... ... Lander ES, et al. Analyses of deep mammalian sequence alignments and constraint predictions for 1% of the human genome. Genome Research. 17: 760-74. PMID 17567995 DOI: 10.1101/gr.6034307  0.96
2007 Xie X, Mikkelsen TS, Gnirke A, Lindblad-Toh K, Kellis M, Lander ES. Systematic discovery of regulatory motifs in conserved regions of the human genome, including thousands of CTCF insulator sites. Proceedings of the National Academy of Sciences of the United States of America. 104: 7145-50. PMID 17442748 DOI: 10.1073/pnas.0701811104  0.44
2007 Bernstein BE, Meissner A, Lander ES. The mammalian epigenome. Cell. 128: 669-81. PMID 17320505 DOI: 10.1016/j.cell.2007.01.033  0.32
2007 Yeo TW, De Jager PL, Gregory SG, Barcellos LF, Walton A, Goris A, Fenoglio C, Ban M, Taylor CJ, Goodman RS, Walsh E, Wolfish CS, Horton R, Traherne J, Beck S, ... ... Lander ES, et al. A second major histocompatibility complex susceptibility locus for multiple sclerosis. Annals of Neurology. 61: 228-36. PMID 17252545 DOI: 10.1002/ana.21063  0.96
2007 Volkman SK, Sabeti PC, DeCaprio D, Neafsey DE, Schaffner SF, Milner DA, Daily JP, Sarr O, Ndiaye D, Ndir O, Mboup S, Duraisingh MT, Lukens A, Derr A, Stange-Thomann N, ... ... Lander ES, et al. A genome-wide map of diversity in Plasmodium falciparum. Nature Genetics. 39: 113-9. PMID 17159979 DOI: 10.1038/ng1930  0.96
2006 Hill AE, Lander ES, Nadeau JH. Chromosome substitution strains: a new way to study genetically complex traits. Methods in Molecular Medicine. 128: 153-72. PMID 17071995 DOI: 10.1385/1-59745-159-2:153  0.96
2006 Bourlat SJ, Juliusdottir T, Lowe CJ, Freeman R, Aronowicz J, Kirschner M, Lander ES, Thorndyke M, Nakano H, Kohn AB, Heyland A, Moroz LL, Copley RR, Telford MJ. Deuterostome phylogeny reveals monophyletic chordates and the new phylum Xenoturbellida. Nature. 444: 85-8. PMID 17051155 DOI: 10.1038/nature05241  0.96
2006 Wei BQ, Mikkelsen TS, McKinney MK, Lander ES, Cravatt BF. A second fatty acid amide hydrolase with variable distribution among placental mammals. The Journal of Biological Chemistry. 281: 36569-78. PMID 17015445 DOI: 10.1074/jbc.M606646200  0.96
2006 Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP, Subramanian A, Ross KN, Reich M, Hieronymus H, Wei G, Armstrong SA, Haggarty SJ, ... ... Lander ES, et al. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science (New York, N.Y.). 313: 1929-35. PMID 17008526 DOI: 10.1126/science.1132939  0.96
2006 Lowe CJ, Terasaki M, Wu M, Freeman RM, Runft L, Kwan K, Haigo S, Aronowicz J, Lander E, Gruber C, Smith M, Kirschner M, Gerhart J. Dorsoventral patterning in hemichordates: insights into early chordate evolution. Plos Biology. 4: e291. PMID 16933975 DOI: 10.1371/journal.pbio.0040291  0.96
2006 Root DE, Hacohen N, Hahn WC, Lander ES, Sabatini DM. Genome-scale loss-of-function screening with a lentiviral RNAi library. Nature Methods. 3: 715-9. PMID 16929317 DOI: 10.1038/nmeth924  0.96
2006 Xie X, Kamal M, Lander ES. A family of conserved noncoding elements derived from an ancient transposable element. Proceedings of the National Academy of Sciences of the United States of America. 103: 11659-64. PMID 16864796 DOI: 10.1073/pnas.0604768103  0.32
2006 Sabeti PC, Schaffner SF, Fry B, Lohmueller J, Varilly P, Shamovsky O, Palma A, Mikkelsen TS, Altshuler D, Lander ES. Positive natural selection in the human lineage. Science (New York, N.Y.). 312: 1614-20. PMID 16778047 DOI: 10.1126/science.1124309  0.96
2006 Patterson N, Richter DJ, Gnerre S, Lander ES, Reich D. Genetic evidence for complex speciation of humans and chimpanzees. Nature. 441: 1103-8. PMID 16710306 DOI: 10.1038/nature04789  0.96
2006 Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, Fry B, Meissner A, Wernig M, Plath K, Jaenisch R, Wagschal A, Feil R, Schreiber SL, Lander ES. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell. 125: 315-26. PMID 16630819 DOI: 10.1016/j.cell.2006.02.041  0.96
2006 Pedersen JS, Bejerano G, Siepel A, Rosenbloom K, Lindblad-Toh K, Lander ES, Kent J, Miller W, Haussler D. Identification and classification of conserved RNA secondary structures in the human genome. Plos Computational Biology. 2: e33. PMID 16628248 DOI: 10.1371/journal.pcbi.0020033  0.96
2006 Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, ... ... Lander ES, et al. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Nature. 440: 1045-9. PMID 16625196 DOI: 10.1038/nature04689  0.96
2006 Zody MC, Garber M, Sharpe T, Young SK, Rowen L, O'Neill K, Whittaker CA, Kamal M, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Kodira CD, Madan A, Qin S, ... ... Lander ES, et al. Analysis of the DNA sequence and duplication history of human chromosome 15. Nature. 440: 671-5. PMID 16572171 DOI: 10.1038/nature04601  0.96
2006 Tello-Ruiz MK, Curley C, DelMonte T, Giallourakis C, Kirby A, Miller K, Wild G, Cohen A, Langelier D, Latiano A, Wedemeyer N, Lander E, Schreiber S, Annese V, Daly MJ, et al. Haplotype-based association analysis of 56 functional candidate genes in the IBD6 locus on chromosome 19. European Journal of Human Genetics : Ejhg. 14: 780-90. PMID 16570073 DOI: 10.1038/sj.ejhg.5201612  0.96
2006 Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N, ... ... Lander ES, et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell. 124: 1283-98. PMID 16564017 DOI: 10.1016/j.cell.2006.01.040  0.96
2006 Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, ... ... Lander ES, et al. Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 440: 497-500. PMID 16554811 DOI: 10.1038/nature04632  0.96
2006 Kamal M, Xie X, Lander ES. A large family of ancient repeat elements in the human genome is under strong selection. Proceedings of the National Academy of Sciences of the United States of America. 103: 2740-5. PMID 16477033 DOI: 10.1073/pnas.0511238103  0.32
2006 Nusbaum C, Mikkelsen TS, Zody MC, Asakawa S, Taudien S, Garber M, Kodira CD, Schueler MG, Shimizu A, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, ... ... Lander ES, et al. DNA sequence and analysis of human chromosome 8. Nature. 439: 331-5. PMID 16421571 DOI: 10.1038/nature04406  0.96
2006 Walsh EC, Sabeti P, Hutcheson HB, Fry B, Schaffner SF, de Bakker PI, Varilly P, Palma AA, Roy J, Cooper R, Winkler C, Zeng Y, de The G, Lander ES, O'Brien S, et al. Searching for signals of evolutionary selection in 168 genes related to immune function. Human Genetics. 119: 92-102. PMID 16362345 DOI: 10.1007/s00439-005-0090-0  0.96
2005 Lindblad-Toh K, Wade CM, Mikkelsen TS, Karlsson EK, Jaffe DB, Kamal M, Clamp M, Chang JL, Kulbokas EJ, Zody MC, Mauceli E, Xie X, Breen M, Wayne RK, Ostrander EA, ... ... Lander ES, et al. Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature. 438: 803-19. PMID 16341006 DOI: 10.1038/nature04338  0.96
2005 Sabeti PC, Walsh E, Schaffner SF, Varilly P, Fry B, Hutcheson HB, Cullen M, Mikkelsen TS, Roy J, Patterson N, Cooper R, Reich D, Altshuler D, O'Brien S, Lander ES. The case for selection at CCR5-Delta32. Plos Biology. 3: e378. PMID 16248677 DOI: 10.1371/journal.pbio.0030378  0.96
2005 Meissner A, Gnirke A, Bell GW, Ramsahoye B, Lander ES, Jaenisch R. Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis. Nucleic Acids Research. 33: 5868-77. PMID 16224102 DOI: 10.1093/nar/gki901  0.96
2005 Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences of the United States of America. 102: 15545-50. PMID 16199517 DOI: 10.1073/pnas.0506580102  0.96
2005 Nusbaum C, Zody MC, Borowsky ML, Kamal M, Kodira CD, Taylor TD, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Abouelleil A, Allen NR, Anderson S, ... ... Lander ES, et al. DNA sequence and analysis of human chromosome 18. Nature. 437: 551-5. PMID 16177791 DOI: 10.1038/nature03983  0.96
2005 Sawcer S, Ban M, Maranian M, Yeo TW, Compston A, Kirby A, Daly MJ, De Jager PL, Walsh E, Lander ES, Rioux JD, Hafler DA, Ivinson A, Rimmler J, Gregory SG, et al. A high-density screen for linkage in multiple sclerosis. American Journal of Human Genetics. 77: 454-67. PMID 16080120 DOI: 10.1086/444547  0.52
2005 Vinson JP, Jaffe DB, O'Neill K, Karlsson EK, Stange-Thomann N, Anderson S, Mesirov JP, Satoh N, Satou Y, Nusbaum C, Birren B, Galagan JE, Lander ES. Assembly of polymorphic genomes: algorithms and application to Ciona savignyi. Genome Research. 15: 1127-35. PMID 16077012 DOI: 10.1101/gr.3722605  0.96
2005 Margulies EH, Vinson JP, Miller W, Jaffe DB, Lindblad-Toh K, Chang JL, Green ED, Lander ES, Mullikin JC, Clamp M. An initial strategy for the systematic identification of functional elements in the human genome by low-redundancy comparative sequencing. Proceedings of the National Academy of Sciences of the United States of America. 102: 4795-800. PMID 15778292 DOI: 10.1073/pnas.0409882102  0.96
2005 Miretti MM, Walsh EC, Ke X, Delgado M, Griffiths M, Hunt S, Morrison J, Whittaker P, Lander ES, Cardon LR, Bentley DR, Rioux JD, Beck S, Deloukas P. A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms. American Journal of Human Genetics. 76: 634-46. PMID 15747258 DOI: 10.1086/429393  0.96
2005 Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, Kellis M. Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature. 434: 338-45. PMID 15735639 DOI: 10.1038/nature03441  0.44
2005 Bernstein BE, Kamal M, Lindblad-Toh K, Bekiranov S, Bailey DK, Huebert DJ, McMahon S, Karlsson EK, Kulbokas EJ, Gingeras TR, Schreiber SL, Lander ES. Genomic maps and comparative analysis of histone modifications in human and mouse. Cell. 120: 169-81. PMID 15680324 DOI: 10.1016/j.cell.2005.01.001  0.96
2005 Ackerman KG, Huang H, Grasemann H, Puma C, Singer JB, Hill AE, Lander E, Nadeau JH, Churchill GA, Drazen JM, Beier DR. Interacting genetic loci cause airway hyperresponsiveness. Physiological Genomics. 21: 105-11. PMID 15657107 DOI: 10.1152/physiolgenomics.00267.2004  0.96
2004 Jaillon O, Aury JM, Brunet F, Petit JL, Stange-Thomann N, Mauceli E, Bouneau L, Fischer C, Ozouf-Costaz C, Bernot A, Nicaud S, Jaffe D, Fisher S, Lutfalla G, Dossat C, ... ... Lander ES, et al. Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype. Nature. 431: 946-57. PMID 15496914 DOI: 10.1038/nature03025  0.96
2004 Rioux JD, Karinen H, Kocher K, McMahon SG, Kärkkäinen P, Janatuinen E, Heikkinen M, Julkunen R, Pihlajamäki J, Naukkarinen A, Kosma VM, Daly MJ, Lander ES, Laakso M. Genomewide search and association studies in a Finnish celiac disease population: Identification of a novel locus and replication of the HLA and CTLA4 loci. American Journal of Medical Genetics. Part A. 130: 345-50. PMID 15386476 DOI: 10.1002/ajmg.a.30072  0.52
2004 Harbison CT, Gordon DB, Lee TI, Rinaldi NJ, Macisaac KD, Danford TW, Hannett NM, Tagne JB, Reynolds DB, Yoo J, Jennings EG, Zeitlinger J, Pokholok DK, Kellis M, Rolfe PA, ... ... Lander ES, et al. Transcriptional regulatory code of a eukaryotic genome. Nature. 431: 99-104. PMID 15343339 DOI: 10.1038/nature02800  0.96
2004 Michalkiewicz M, Michalkiewicz T, Ettinger RA, Rutledge EA, Fuller JM, Moralejo DH, Van Yserloo B, MacMurray AJ, Kwitek AE, Jacob HJ, Lander ES, Lernmark A. Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat. Physiological Genomics. 19: 228-32. PMID 15328390 DOI: 10.1152/physiolgenomics.00126.2004  0.96
2004 Kellis M, Patterson N, Birren B, Berger B, Lander ES. Methods in comparative genomics: genome correspondence, gene identification and regulatory motif discovery. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 11: 319-55. PMID 15285895 DOI: 10.1089/1066527041410319  0.44
2004 Krewson TD, Supelak PJ, Hill AE, Singer JB, Lander ES, Nadeau JH, Palmert MR. Chromosomes 6 and 13 harbor genes that regulate pubertal timing in mouse chromosome substitution strains. Endocrinology. 145: 4447-51. PMID 15284200 DOI: 10.1210/en.2004-0543  0.96
2004 Sawcer SJ, Maranian M, Singlehurst S, Yeo T, Compston A, Daly MJ, De Jager PL, Gabriel S, Hafler DA, Ivinson AJ, Lander ES, Rioux JD, Walsh E, Gregory SG, Schmidt S, et al. Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping. Human Molecular Genetics. 13: 1943-9. PMID 15238506 DOI: 10.1093/hmg/ddh202  0.96
2004 Tantisira KG, Lake S, Silverman ES, Palmer LJ, Lazarus R, Silverman EK, Liggett SB, Gelfand EW, Rosenwasser LJ, Richter B, Israel E, Wechsler M, Gabriel S, Altshuler D, Lander E, et al. Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Human Molecular Genetics. 13: 1353-9. PMID 15128701 DOI: 10.1093/hmg/ddh149  0.32
2004 Mootha VK, Handschin C, Arlow D, Xie X, St Pierre J, Sihag S, Yang W, Altshuler D, Puigserver P, Patterson N, Willy PJ, Schulman IG, Heyman RA, Lander ES, Spiegelman BM. Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proceedings of the National Academy of Sciences of the United States of America. 101: 6570-5. PMID 15100410 DOI: 10.1073/pnas.0401401101  0.96
2004 Freedman ML, Reich D, Penney KL, McDonald GJ, Mignault AA, Patterson N, Gabriel SB, Topol EJ, Smoller JW, Pato CN, Pato MT, Petryshen TL, Kolonel LN, Lander ES, Sklar P, et al. Assessing the impact of population stratification on genetic association studies. Nature Genetics. 36: 388-93. PMID 15052270 DOI: 10.1038/ng1333  0.96
2004 Singer JB, Hill AE, Burrage LC, Olszens KR, Song J, Justice M, O'Brien WE, Conti DV, Witte JS, Lander ES, Nadeau JH. Genetic dissection of complex traits with chromosome substitution strains of mice. Science (New York, N.Y.). 304: 445-8. PMID 15031436 DOI: 10.1126/science.1093139  0.96
2004 Kellis M, Birren BW, Lander ES. Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae. Nature. 428: 617-24. PMID 15004568 DOI: 10.1038/nature02424  0.44
2004 Sklar P, Pato MT, Kirby A, Petryshen TL, Medeiros H, Carvalho C, Macedo A, Dourado A, Coelho I, Valente J, Soares MJ, Ferreira CP, Lei M, Verner A, Hudson TJ, ... ... Lander E, et al. Genome-wide scan in Portuguese Island families identifies 5q31-5q35 as a susceptibility locus for schizophrenia and psychosis. Molecular Psychiatry. 9: 213-8. PMID 14699422 DOI: 10.1038/sj.mp.4001418  0.96
2003 Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES, Mann M. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell. 115: 629-40. PMID 14651853  0.44
2003 Moses AM, Chiang DY, Kellis M, Lander ES, Eisen MB. Position specific variation in the rate of evolution in transcription factor binding sites. Bmc Evolutionary Biology. 3: 19. PMID 12946282 DOI: 10.1186/1471-2148-3-19  0.96
2003 Walsh EC, Mather KA, Schaffner SF, Farwell L, Daly MJ, Patterson N, Cullen M, Carrington M, Bugawan TL, Erlich H, Campbell J, Barrett J, Miller K, Thomson G, Lander ES, et al. An integrated haplotype map of the human major histocompatibility complex. American Journal of Human Genetics. 73: 580-90. PMID 12920676 DOI: 10.1086/378101  0.96
2003 Chiang DY, Moses AM, Kellis M, Lander ES, Eisen MB. Phylogenetically and spatially conserved word pairs associated with gene-expression changes in yeasts. Genome Biology. 4: R43. PMID 12844359 DOI: 10.1186/gb-2003-4-7-r43  0.96
2003 Lowe CJ, Wu M, Salic A, Evans L, Lander E, Stange-Thomann N, Gruber CE, Gerhart J, Kirschner M. Anteroposterior patterning in hemichordates and the origins of the chordate nervous system. Cell. 113: 853-65. PMID 12837244 DOI: 10.1016/S0092-8674(03)00469-0  0.96
2003 Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, RidderstrÃ¥le M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, ... ... Lander ES, et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nature Genetics. 34: 267-73. PMID 12808457 DOI: 10.1038/ng1180  0.96
2003 Giallourakis C, Stoll M, Miller K, Hampe J, Lander ES, Daly MJ, Schreiber S, Rioux JD. IBD5 is a general risk factor for inflammatory bowel disease: replication of association with Crohn disease and identification of a novel association with ulcerative colitis. American Journal of Human Genetics. 73: 205-11. PMID 12776251 DOI: 10.1086/376417  0.52
2003 Kellis M, Patterson N, Endrizzi M, Birren B, Lander ES. Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature. 423: 241-54. PMID 12748633 DOI: 10.1038/nature01644  0.44
2003 Galagan JE, Calvo SE, Borkovich KA, Selker EU, Read ND, Jaffe D, FitzHugh W, Ma LJ, Smirnov S, Purcell S, Rehman B, Elkins T, Engels R, Wang S, Nielsen CB, ... ... Lander ES, et al. The genome sequence of the filamentous fungus Neurospora crassa. Nature. 422: 859-68. PMID 12712197 DOI: 10.1038/nature01554  0.96
2003 Xu Y, Stange-Thomann N, Weber G, Bo R, Dodge S, David RG, Foley K, Beheshti J, Harris NL, Birren B, Lander ES, Meyerson M. Pathogen discovery from human tissue by sequence-based computational subtraction. Genomics. 81: 329-35. PMID 12659816 DOI: 10.1016/S0888-7543(02)00043-5  0.96
2003 Waterston RH, Lander ES, Sulston JE. More on the sequencing of the human genome. Proceedings of the National Academy of Sciences of the United States of America. 100: 3022-4; author reply. PMID 12631699 DOI: 10.1073/pnas.0634129100  0.96
2003 Mootha VK, Lepage P, Miller K, Bunkenborg J, Reich M, Hjerrild M, Delmonte T, Villeneuve A, Sladek R, Xu F, Mitchell GA, Morin C, Mann M, Hudson TJ, Robinson B, ... ... Lander ES, et al. Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics. Proceedings of the National Academy of Sciences of the United States of America. 100: 605-10. PMID 12529507 DOI: 10.1073/pnas.242716699  0.96
2003 Jaffe DB, Butler J, Gnerre S, Mauceli E, Lindblad-Toh K, Mesirov JP, Zody MC, Lander ES. Whole-genome sequence assembly for mammalian genomes: Arachne 2. Genome Research. 13: 91-6. PMID 12529310 DOI: 10.1101/gr.828403  0.96
2003 Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nature Genetics. 33: 177-82. PMID 12524541 DOI: 10.1038/ng1071  0.96
2003 Ramaswamy S, Ross KN, Lander ES, Golub TR. A molecular signature of metastasis in primary solid tumors. Nature Genetics. 33: 49-54. PMID 12469122 DOI: 10.1038/ng1060  0.96
2002 Wade CM, Kulbokas EJ, Kirby AW, Zody MC, Mullikin JC, Lander ES, Lindblad-Toh K, Daly MJ. The mosaic structure of variation in the laboratory mouse genome. Nature. 420: 574-8. PMID 12466852 DOI: 10.1038/nature01252  0.52
2002 Williams CN, Kocher K, Lander ES, Daly MJ, Rioux JD. Using a genome-wide scan and meta-analysis to identify a novel IBD locus and confirm previously identified IBD loci. Inflammatory Bowel Diseases. 8: 375-81. PMID 12454612 DOI: 10.1097/00054725-200211000-00001  0.96
2002 Chen CZ, Li M, de Graaf D, Monti S, Göttgens B, Sanchez MJ, Lander ES, Golub TR, Green AR, Lodish HF. Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 99: 15468-73. PMID 12438646 DOI: 10.1073/pnas.202614899  0.96
2002 Cowles CR, Hirschhorn JN, Altshuler D, Lander ES. Detection of regulatory variation in mouse genes. Nature Genetics. 32: 432-7. PMID 12410233 DOI: 10.1038/ng992  0.96
2002 Sabeti PC, Reich DE, Higgins JM, Levine HZ, Richter DJ, Schaffner SF, Gabriel SB, Platko JV, Patterson NJ, McDonald GJ, Ackerman HC, Campbell SJ, Altshuler D, Cooper R, Kwiatkowski D, ... ... Lander ES, et al. Detecting recent positive selection in the human genome from haplotype structure. Nature. 419: 832-7. PMID 12397357 DOI: 10.1038/nature01140  0.96
2002 Reich DE, Schaffner SF, Daly MJ, McVean G, Mullikin JC, Higgins JM, Richter DJ, Lander ES, Altshuler D. Human genome sequence variation and the influence of gene history, mutation and recombination. Nature Genetics. 32: 135-42. PMID 12161752 DOI: 10.1038/ng947  0.96
2002 MacMurray AJ, Moralejo DH, Kwitek AE, Rutledge EA, Van Yserloo B, Gohlke P, Speros SJ, Snyder B, Schaefer J, Bieg S, Jiang J, Ettinger RA, Fuller J, Daniels TL, Pettersson A, ... ... Lander ES, et al. Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. Genome Research. 12: 1029-39. PMID 12097339 DOI: 10.1101/gr.412702  0.96
2002 Ferrando AA, Neuberg DS, Staunton J, Loh ML, Huard C, Raimondi SC, Behm FG, Pui CH, Downing JR, Gilliland DG, Lander ES, Golub TR, Look AT. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell. 1: 75-87. PMID 12086890 DOI: 10.1016/S1535-6108(02)00018-1  0.96
2002 Singh D, Febbo PG, Ross K, Jackson DG, Manola J, Ladd C, Tamayo P, Renshaw AA, D'Amico AV, Richie JP, Lander ES, Loda M, Kantoff PW, Golub TR, Sellers WR. Gene expression correlates of clinical prostate cancer behavior. Cancer Cell. 1: 203-9. PMID 12086878 DOI: 10.1016/S1535-6108(02)00030-2  0.96
2002 Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, ... Lander ES, et al. The structure of haplotype blocks in the human genome. Science (New York, N.Y.). 296: 2225-9. PMID 12029063 DOI: 10.1126/science.1069424  0.52
2002 Waterston RH, Lander ES, Sulston JE. On the sequencing of the human genome. Proceedings of the National Academy of Sciences of the United States of America. 99: 3712-6. PMID 11880605 DOI: 10.1073/pnas.042692499  0.96
2002 Pomeroy SL, Tamayo P, Gaasenbeek M, Sturla LM, Angelo M, McLaughlin ME, Kim JY, Goumnerova LC, Black PM, Lau C, Allen JC, Zagzag D, Olson JM, Curran T, Wetmore C, ... ... Lander ES, et al. Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature. 415: 436-42. PMID 11807556 DOI: 10.1038/415436a  0.96
2002 Lindgren CM, Mahtani MM, Widén E, McCarthy MI, Daly MJ, Kirby A, Reeve MP, Kruglyak L, Parker A, Meyer J, Almgren P, Lehto M, Kanninen T, Tuomi T, Groop LC, ... Lander ES, et al. Genomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families: the Botnia study. American Journal of Human Genetics. 70: 509-16. PMID 11791216 DOI: 10.1086/338629  0.96
2002 Shipp MA, Ross KN, Tamayo P, Weng AP, Kutok JL, Aguiar RC, Gaasenbeek M, Angelo M, Reich M, Pinkus GS, Ray TS, Koval MA, Last KW, Norton A, Lister TA, ... ... Lander ES, et al. Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning. Nature Medicine. 8: 68-74. PMID 11786909 DOI: 10.1038/nm0102-68  0.96
2002 Batzoglou S, Jaffe DB, Stanley K, Butler J, Gnerre S, Mauceli E, Berger B, Mesirov JP, Lander ES. ARACHNE: a whole-genome shotgun assembler. Genome Research. 12: 177-89. PMID 11779843 DOI: 10.1101/gr.208902  0.96
2002 Armstrong SA, Staunton JE, Silverman LB, Pieters R, den Boer ML, Minden MD, Sallan SE, Lander ES, Golub TR, Korsmeyer SJ. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nature Genetics. 30: 41-7. PMID 11731795 DOI: 10.1038/ng765  0.96
2001 Lindblad-Toh K, Lander ES, McPherson JD, Waterston RH, Rodgers J, Birney E. Progress in sequencing the mouse genome. Genesis (New York, N.Y. : 2000). 31: 137-41. PMID 11783003 DOI: 10.1002/gene.10016  0.96
2001 Ramaswamy S, Tamayo P, Rifkin R, Mukherjee S, Yeang CH, Angelo M, Ladd C, Reich M, Latulippe E, Mesirov JP, Poggio T, Gerald W, Loda M, Lander ES, Golub TR. Multiclass cancer diagnosis using tumor gene expression signatures. Proceedings of the National Academy of Sciences of the United States of America. 98: 15149-54. PMID 11742071 DOI: 10.1073/pnas.211566398  0.96
2001 Bhattacharjee A, Richards WG, Staunton J, Li C, Monti S, Vasa P, Ladd C, Beheshti J, Bueno R, Gillette M, Loda M, Weber G, Mark EJ, Lander ES, Wong W, et al. Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proceedings of the National Academy of Sciences of the United States of America. 98: 13790-5. PMID 11707567 DOI: 10.1073/pnas.191502998  0.96
2001 Huang Q, Liu D, Majewski P, Schulte LC, Korn JM, Young RA, Lander ES, Hacohen N. The plasticity of dendritic cell responses to pathogens and their components. Science (New York, N.Y.). 294: 870-5. PMID 11679675 DOI: 10.1126/science.294.5543.870  0.96
2001 Daly MJ, Rioux JD, Schaffner SF, Hudson TJ, Lander ES. High-resolution haplotype structure in the human genome. Nature Genetics. 29: 229-32. PMID 11586305 DOI: 10.1038/ng1001-229  0.96
2001 Rioux JD, Daly MJ, Silverberg MS, Lindblad K, Steinhart H, Cohen Z, Delmonte T, Kocher K, Miller K, Guschwan S, Kulbokas EJ, O'Leary S, Winchester E, Dewar K, Green T, ... ... Lander ES, et al. Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nature Genetics. 29: 223-8. PMID 11586304 DOI: 10.1038/ng1001-223  0.96
2001 Hudson TJ, Church DM, Greenaway S, Nguyen H, Cook A, Steen RG, Van Etten WJ, Castle AB, Strivens MA, Trickett P, Heuston C, Davison C, Southwell A, Hardisty R, Varela-Carver A, ... ... Lander ES, et al. A radiation hybrid map of mouse genes. Nature Genetics. 29: 201-5. PMID 11586302 DOI: 10.1038/ng1001-201  0.96
2001 Staunton JE, Slonim DK, Coller HA, Tamayo P, Angelo MJ, Park J, Scherf U, Lee JK, Reinhold WO, Weinstein JN, Mesirov JP, Lander ES, Golub TR. Chemosensitivity prediction by transcriptional profiling. Proceedings of the National Academy of Sciences of the United States of America. 98: 10787-92. PMID 11553813 DOI: 10.1073/pnas.191368598  0.96
2001 Barclay J, Balaguero N, Mione M, Ackerman SL, Letts VA, Brodbeck J, Canti C, Meir A, Page KM, Kusumi K, Perez-Reyes E, Lander ES, Frankel WN, Gardiner RM, Dolphin AC, et al. Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 6095-104. PMID 11487633  0.96
2001 Ardlie K, Liu-Cordero SN, Eberle MA, Daly M, Barrett J, Winchester E, Lander ES, Kruglyak L. Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion. American Journal of Human Genetics. 69: 582-9. PMID 11473344 DOI: 10.1086/323251  0.96
2001 Yeang CH, Ramaswamy S, Tamayo P, Mukherjee S, Rifkin RM, Angelo M, Reich M, Lander E, Mesirov J, Golub T. Molecular classification of multiple tumor types. Bioinformatics (Oxford, England). 17: S316-22. PMID 11473023  0.96
2001 Hirschhorn JN, Lindgren CM, Daly MJ, Kirby A, Schaffner SF, Burtt NP, Altshuler D, Parker A, Rioux JD, Platko J, Gaudet D, Hudson TJ, Groop LC, Lander ES. Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height. American Journal of Human Genetics. 69: 106-16. PMID 11410839 DOI: 10.1086/321287  0.96
2001 Inoue K, Dewar K, Katsanis N, Reiter LT, Lander ES, Devon KL, Wyman DW, Lupski JR, Birren B. The 1.4-Mb CMT1A duplication/HNPP deletion genomic region reveals unique genome architectural features and provides insights into the recent evolution of new genes. Genome Research. 11: 1018-33. PMID 11381029 DOI: 10.1101/gr.180401  0.44
2001 Reich DE, Cargill M, Bolk S, Ireland J, Sabeti PC, Richter DJ, Lavery T, Kouyoumjian R, Farhadian SF, Ward R, Lander ES. Linkage disequilibrium in the human genome. Nature. 411: 199-204. PMID 11346797 DOI: 10.1038/35075590  0.96
2001 Laitinen T, Daly MJ, Rioux JD, Kauppi P, Laprise C, Petäys T, Green T, Cargill M, Haahtela T, Lander ES, Laitinen LA, Hudson TJ, Kere J. A susceptibility locus for asthma-related traits on chromosome 7 revealed by genome-wide scan in a founder population. Nature Genetics. 28: 87-91. PMID 11326283 DOI: 10.1038/88319  0.96
2001 Sweeney C, Fambrough D, Huard C, Diamonti AJ, Lander ES, Cantley LC, Carraway KL. Growth factor-specific signaling pathway stimulation and gene expression mediated by ErbB receptors. The Journal of Biological Chemistry. 276: 22685-98. PMID 11297548 DOI: 10.1074/jbc.M100602200  0.96
2001 Sachidanandam R, Weissman D, Schmidt SC, Kakol JM, Stein LD, Marth G, Sherry S, Mullikin JC, Mortimore BJ, Willey DL, Hunt SE, Cole CG, Coggill PC, Rice CM, Ning Z, ... ... Lander ES, et al. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature. 409: 928-33. PMID 11237013 DOI: 10.1038/35057149  0.96
2001 Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, et al. Initial sequencing and analysis of the human genome. Nature. 409: 860-921. PMID 11237011 DOI: 10.1038/35057062  0.96
2001 Causton HC, Ren B, Koh SS, Harbison CT, Kanin E, Jennings EG, Lee TI, True HL, Lander ES, Young RA. Remodeling of yeast genome expression in response to environmental changes. Molecular Biology of the Cell. 12: 323-37. PMID 11179418  0.96
2001 Lee N, Daly MJ, Delmonte T, Lander ES, Xu F, Hudson TJ, Mitchell GA, Morin CC, Robinson BH, Rioux JD. A genomewide linkage-disequilibrium scan localizes the Saguenay-Lac-Saint-Jean cytochrome oxidase deficiency to 2p16. American Journal of Human Genetics. 68: 397-409. PMID 11156535 DOI: 10.1086/318197  0.96
2001 Jackson-Grusby L, Beard C, Possemato R, Tudor M, Fambrough D, Csankovszki G, Dausman J, Lee P, Wilson C, Lander E, Jaenisch R. Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Nature Genetics. 27: 31-9. PMID 11137995 DOI: 10.1038/83730  0.96
2000 Hirschhorn JN, Sklar P, Lindblad-Toh K, Lim YM, Ruiz-Gutierrez M, Bolk S, Langhorst B, Schaffner S, Winchester E, Lander ES. SBE-TAGS: an array-based method for efficient single-nucleotide polymorphism genotyping. Proceedings of the National Academy of Sciences of the United States of America. 97: 12164-9. PMID 11035790 DOI: 10.1073/pnas.210394597  0.96
2000 Altshuler D, Pollara VJ, Cowles CR, Van Etten WJ, Baldwin J, Linton L, Lander ES. An SNP map of the human genome generated by reduced representation shotgun sequencing. Nature. 407: 513-6. PMID 11029002 DOI: 10.1038/35035083  0.32
2000 Altshuler D, Hirschhorn JN, Klannemark M, Lindgren CM, Vohl MC, Nemesh J, Lane CR, Schaffner SF, Bolk S, Brewer C, Tuomi T, Gaudet D, Hudson TJ, Daly M, Groop L, ... Lander ES, et al. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nature Genetics. 26: 76-80. PMID 10973253 DOI: 10.1038/79216  0.96
2000 Lindblad-Toh K, Tanenbaum DM, Daly MJ, Winchester E, Lui WO, Villapakkam A, Stanton SE, Larsson C, Hudson TJ, Johnson BE, Lander ES, Meyerson M. Loss-of-heterozygosity analysis of small-cell lung carcinomas using single-nucleotide polymorphism arrays. Nature Biotechnology. 18: 1001-5. PMID 10973224 DOI: 10.1038/79269  0.96
2000 Clark EA, Golub TR, Lander ES, Hynes RO. Genomic analysis of metastasis reveals an essential role for RhoC. Nature. 406: 532-5. PMID 10952316 DOI: 10.1038/35020106  0.96
2000 Cormier RT, Bilger A, Lillich AJ, Halberg RB, Hong KH, Gould KA, Borenstein N, Lander ES, Dove WF. The Mom1AKR intestinal tumor resistance region consists of Pla2g2a and a locus distal to D4Mit64. Oncogene. 19: 3182-92. PMID 10918573 DOI: 10.1038/sj.onc.1203646  0.96
2000 Batzoglou S, Pachter L, Mesirov JP, Berger B, Lander ES. Human and mouse gene structure: comparative analysis and application to exon prediction. Genome Research. 10: 950-8. PMID 10899144 DOI: 10.1101/gr.10.7.950  0.96
2000 Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, McLeod RS, Griffiths AM, Green T, Brettin TS, Stone V, Bull SB, Bitton A, Williams CN, Greenberg GR, Cohen Z, Lander ES, et al. Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. American Journal of Human Genetics. 66: 1863-70. PMID 10777714 DOI: 10.1086/302913  0.52
2000 Lander ES, Weinberg RA. Genomics: journey to the center of biology. Science (New York, N.Y.). 287: 1777-82. PMID 10755930  0.96
2000 Bulman MP, Kusumi K, Frayling TM, McKeown C, Garrett C, Lander ES, Krumlauf R, Hattersley AT, Ellard S, Turnpenny PD. Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis. Nature Genetics. 24: 438-41. PMID 10742114 DOI: 10.1038/74307  0.96
2000 Lindblad-Toh K, Winchester E, Daly MJ, Wang DG, Hirschhorn JN, Laviolette JP, Ardlie K, Reich DE, Robinson E, Sklar P, Shah N, Thomas D, Fan JB, Gingeras T, Warrington J, ... ... Lander ES, et al. Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse. Nature Genetics. 24: 381-6. PMID 10742102 DOI: 10.1038/74215  0.96
2000 Coller HA, Grandori C, Tamayo P, Colbert T, Lander ES, Eisenman RN, Golub TR. Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Proceedings of the National Academy of Sciences of the United States of America. 97: 3260-5. PMID 10737792 DOI: 10.1073/pnas.97.7.3260  0.96
1999 Batzoglou S, Berger B, Mesirov J, Lander ES. Sequencing a genome by walking with clone-end sequences: a mathematical analysis. Genome Research. 9: 1163-74. PMID 10613838 DOI: 10.1101/gr.9.12.1163  0.96
1999 De Sanctis GT, Singer JB, Jiao A, Yandava CN, Lee YH, Haynes TC, Lander ES, Beier DR, Drazen JM. Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice. The American Journal of Physiology. 277: L1118-23. PMID 10600881  0.96
1999 Wyrick JJ, Holstege FC, Jennings EG, Causton HC, Shore D, Grunstein M, Lander ES, Young RA. Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast. Nature. 402: 418-21. PMID 10586882 DOI: 10.1038/46567  0.96
1999 Pachter L, Batzoglou S, Spitkovsky VI, Banks E, Lander ES, Kleitman DJ, Berger B. A dictionary-based approach for gene annotation. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 6: 419-30. PMID 10582576 DOI: 10.1089/106652799318364  0.96
1999 Madhani HD, Galitski T, Lander ES, Fink GR. Effectors of a developmental mitogen-activated protein kinase cascade revealed by expression signatures of signaling mutants. Proceedings of the National Academy of Sciences of the United States of America. 96: 12530-5. PMID 10535956 DOI: 10.1073/pnas.96.22.12530  0.96
1999 Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP, Coller H, Loh ML, Downing JR, Caligiuri MA, Bloomfield CD, Lander ES. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science (New York, N.Y.). 286: 531-7. PMID 10521349 DOI: 10.1126/science.286.5439.531  0.96
1998 McCarthy MI, Kruglyak L, Lander ES. Sib-pair collection strategies for complex diseases. Genetic Epidemiology. 15: 317-40. PMID 9671984 DOI: 10.1002/(SICI)1098-2272(1998)15:4<317::AID-GEPI1>3.0.CO;2-#  0.96
1998 Altshuler D, Kruglyak L, Lander E. Genetic polymorphisms and disease. The New England Journal of Medicine. 338: 1626. PMID 9606122 DOI: 10.1056/NEJM199805283382214  0.96
1998 Wang DG, Fan JB, Siao CJ, Berno A, Young P, Sapolsky R, Ghandour G, Perkins N, Winchester E, Spencer J, Kruglyak L, Stein L, Hsie L, Topaloglou T, Hubbell E, ... ... Lander ES, et al. Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science (New York, N.Y.). 280: 1077-82. PMID 9582121 DOI: 10.1126/science.280.5366.1077  0.96
1998 Kruglyak L, Lander ES. Faster multipoint linkage analysis using Fourier transforms. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 5: 1-7. PMID 9541867  0.96
1997 Slonim D, Kruglyak L, Stein L, Lander E. Building human genome maps with radiation hybrids. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 4: 487-504. PMID 9385541  0.96
1997 Laitinen T, Kauppi P, Ignatius J, Ruotsalainen T, Daly MJ, Kääriäinen H, Kruglyak L, Laitinen H, de la Chapelle A, Lander ES, Laitinen LA, Kere J. Genetic control of serum IgE levels and asthma: linkage and linkage disequilibrium studies in an isolated population. Human Molecular Genetics. 6: 2069-76. PMID 9328470 DOI: 10.1093/hmg/6.12.2069  0.96
1997 Hamilton BA, Smith DJ, Mueller KL, Kerrebrock AW, Bronson RT, van Berkel V, Daly MJ, Kruglyak L, Reeve MP, Nemhauser JL, Hawkins TL, Rubin EM, Lander ES. The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron. 18: 711-22. PMID 9182797 DOI: 10.1016/S0896-6273(00)80312-8  0.96
1996 Mahtani MM, Widén E, Lehto M, Thomas J, McCarthy M, Brayer J, Bryant B, Chan G, Daly M, Forsblom C, Kanninen T, Kirby A, Kruglyak L, Munnelly K, Parkkonen M, ... ... Lander ES, et al. Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nature Genetics. 14: 90-4. PMID 8782826 DOI: 10.1038/ng0996-90  1
1996 Gschwend M, Levran O, Kruglyak L, Ranade K, Verlander PC, Shen S, Faure S, Weissenbach J, Altay C, Lander ES, Auerbach AD, Botstein D. A locus for Fanconi anemia on 16q determined by homozygosity mapping. American Journal of Human Genetics. 59: 377-84. PMID 8755924  0.96
1996 Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. Parametric and nonparametric linkage analysis: a unified multipoint approach. American Journal of Human Genetics. 58: 1347-63. PMID 8651312  0.96
1996 Kruglyak L, Lander ES. Limits on fine mapping of complex traits. American Journal of Human Genetics. 58: 1092-3. PMID 8651271  0.96
1996 Hamilton BA, Frankel WN, Kerrebrock AW, Hawkins TL, FitzHugh W, Kusumi K, Russell LB, Mueller KL, van Berkel V, Birren BW, Kruglyak L, Lander ES. Disruption of the nuclear hormone receptor RORalpha in staggerer mice. Nature. 379: 736-9. PMID 8602221 DOI: 10.1038/379736a0  0.96
1995 Hudson TJ, Stein LD, Gerety SS, Ma J, Castle AB, Silva J, Slonim DK, Baptista R, Kruglyak L, Xu SH, Hu X, Colbert AM, Rosenberg C, Reeve-Daly MP, Rozen S, ... ... Lander ES, et al. An STS-based map of the human genome. Science (New York, N.Y.). 270: 1945-54. PMID 8533086  0.96
1995 Kruglyak L, Daly MJ, Lander ES. Rapid multipoint linkage analysis of recessive traits in nuclear families, including homozygosity mapping. American Journal of Human Genetics. 56: 519-27. PMID 7847388  0.96
1995 Kruglyak L, Lander ES. A nonparametric approach for mapping quantitative trait loci. Genetics. 139: 1421-8. PMID 7768449  0.96
1995 Kruglyak L, Lander ES. High-resolution genetic mapping of complex traits. American Journal of Human Genetics. 56: 1212-23. PMID 7726179  0.96
1995 Kruglyak L, Lander ES. Complete multipoint sib-pair analysis of qualitative and quantitative traits. American Journal of Human Genetics. 57: 439-54. PMID 7668271  0.96
1995 Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genetics. 11: 241-7. PMID 7581446 DOI: 10.1038/ng1195-241  0.96
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