| Year |
Citation |
Score |
| 2022 |
Fang F, Goldstein JL, Shi X, Liang G, Brown MS. Unexpected role for IGF-1 in starvation: Maintenance of blood glucose. Proceedings of the National Academy of Sciences of the United States of America. 119: e2208855119. PMID 35914126 DOI: 10.1073/pnas.2208855119 |
0.316 |
|
| 2022 |
Trinh MN, Brown MS, Seemann J, Vale G, McDonald JG, Goldstein JL, Lu F. Interplay between Asters/GRAMD1s and phosphatidylserine in intermembrane transport of LDL cholesterol. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 34992143 DOI: 10.1073/pnas.2120411119 |
0.487 |
|
| 2021 |
Kober DL, Radhakrishnan A, Goldstein JL, Brown MS, Clark LD, Bai XC, Rosenbaum DM. Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing. Cell. PMID 34139175 DOI: 10.1016/j.cell.2021.05.019 |
0.446 |
|
| 2020 |
Trinh MN, Brown MS, Goldstein JL, Han J, Vale G, McDonald JG, Seemann J, Mendell JT, Lu F. Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine. Proceedings of the National Academy of Sciences of the United States of America. PMID 32690708 DOI: 10.1073/Pnas.2010682117 |
0.578 |
|
| 2019 |
Fang F, Shi X, Brown MS, Goldstein JL, Liang G. Growth hormone acts on liver to stimulate autophagy, support glucose production, and preserve blood glucose in chronically starved mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 30910968 DOI: 10.1073/pnas.1901867116 |
0.411 |
|
| 2018 |
Trinh MN, Brown MS, Seemann J, Goldstein JL, Lu F. Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1. Elife. 7. PMID 30047864 DOI: 10.7554/eLife.38564 |
0.533 |
|
| 2018 |
Tian J, Wu J, Chen X, Guo T, Chen ZJ, Goldstein JL, Brown MS. BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver. Elife. 7. PMID 29952285 DOI: 10.7554/eLife.36826 |
0.423 |
|
| 2018 |
Trinh MN, Brown MS, Seemann J, Goldstein JL, Lu F. Author response: Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1 Elife. DOI: 10.7554/Elife.38564.013 |
0.477 |
|
| 2018 |
Tian J, Wu J, Chen X, Guo T, Chen ZJ, Goldstein JL, Brown MS. Author response: BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver Elife. DOI: 10.7554/Elife.36826.016 |
0.407 |
|
| 2017 |
Brown MS, Radhakrishnan A, Goldstein JL. Retrospective on Cholesterol Homeostasis: The Central Role of Scap. Annual Review of Biochemistry. PMID 28841344 DOI: 10.1146/Annurev-Biochem-062917-011852 |
0.555 |
|
| 2017 |
Gao Y, Zhou Y, Goldstein JL, Brown MS, Radhakrishnan A. Cholesterol-induced conformation changes in the sterol-sensing domain of the scap protein suggest feedback mechanism to control cholesterol synthesis. The Journal of Biological Chemistry. PMID 28377508 DOI: 10.1074/Jbc.M117.783894 |
0.558 |
|
| 2016 |
Trinh MN, Lu F, Li X, Das A, Liang Q, De Brabander JK, Brown MS, Goldstein JL. Triazoles inhibit cholesterol export from lysosomes by binding to NPC1. Proceedings of the National Academy of Sciences of the United States of America. PMID 27994139 DOI: 10.1073/Pnas.1619571114 |
0.501 |
|
| 2016 |
Tian J, Goldstein JL, Brown MS. Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complex. Proceedings of the National Academy of Sciences of the United States of America. PMID 27382175 DOI: 10.1073/pnas.1608987113 |
0.442 |
|
| 2016 |
Zhang Y, Lee KM, Kinch LN, Clark L, Grishin NV, Rosenbaum DM, Brown MS, Goldstein JL, Radhakrishnan A. Direct Demonstration that Loop1 of Scap Binds to Loop7, a crucial event in cholesterol homeostasis. The Journal of Biological Chemistry. PMID 27068746 DOI: 10.1074/Jbc.M116.729798 |
0.514 |
|
| 2015 |
Lu F, Liang Q, Abi-Mosleh L, Das A, De Brabander JK, Goldstein JL, Brown MS. Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection. Elife. 4. PMID 26646182 DOI: 10.7554/Elife.12177 |
0.653 |
|
| 2015 |
Goldstein JL, Brown MS. A century of cholesterol and coronaries: from plaques to genes to statins. Cell. 161: 161-72. PMID 25815993 DOI: 10.1016/j.cell.2015.01.036 |
0.509 |
|
| 2015 |
Zhang Y, Fang F, Goldstein JL, Brown MS, Zhao TJ. Reduced autophagy in livers of fasted, fat-depleted, ghrelin-deficient mice: reversal by growth hormone. Proceedings of the National Academy of Sciences of the United States of America. 112: 1226-31. PMID 25583513 DOI: 10.1073/pnas.1423643112 |
0.421 |
|
| 2015 |
Lu F, Liang Q, Abi-Mosleh L, Das A, Brabander JKD, Goldstein JL, Brown MS. Author response: Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection Elife. DOI: 10.7554/Elife.12177.012 |
0.439 |
|
| 2014 |
Das A, Brown MS, Anderson DD, Goldstein JL, Radhakrishnan A. Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis. Elife. 3. PMID 24920391 DOI: 10.7554/Elife.02882 |
0.517 |
|
| 2014 |
McFarlane MR, Brown MS, Goldstein JL, Zhao TJ. Induced ablation of ghrelin cells in adult mice does not decrease food intake, body weight, or response to high-fat diet. Cell Metabolism. 20: 54-60. PMID 24836560 DOI: 10.1016/j.cmet.2014.04.007 |
0.414 |
|
| 2014 |
Nurse P, Goldstein JL, Brown MS, Greider C, Baltimore D. Emerging themes in biology: Hints for the future Cell. 157: 272-273. DOI: 10.1016/J.Cell.2014.03.013 |
0.36 |
|
| 2013 |
Das A, Goldstein JL, Anderson DD, Brown MS, Radhakrishnan A. Use of mutant 125I-perfringolysin O to probe transport and organization of cholesterol in membranes of animal cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 10580-5. PMID 23754385 DOI: 10.1073/Pnas.1309273110 |
0.545 |
|
| 2013 |
Zhang Y, Motamed M, Seemann J, Brown MS, Goldstein JL. Point mutation in luminal loop 7 of Scap protein blocks interaction with loop 1 and abolishes movement to Golgi. The Journal of Biological Chemistry. 288: 14059-67. PMID 23564452 DOI: 10.1074/jbc.M113.469528 |
0.487 |
|
| 2012 |
Goldstein JL, Brown MS. History of science. A golden era of Nobel laureates. Science (New York, N.Y.). 338: 1033-4. PMID 23180848 DOI: 10.1126/science.1231699 |
0.393 |
|
| 2012 |
Owen JL, Zhang Y, Bae SH, Farooqi MS, Liang G, Hammer RE, Goldstein JL, Brown MS. Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase. Proceedings of the National Academy of Sciences of the United States of America. 109: 16184-9. PMID 22927400 DOI: 10.1073/pnas.1213343109 |
0.423 |
|
| 2012 |
Brown MS, Goldstein JL. Scientific side trips: six excursions from the beaten path. The Journal of Biological Chemistry. 287: 22418-35. PMID 22584575 DOI: 10.1074/jbc.X112.381681 |
0.333 |
|
| 2012 |
Li RL, Sherbet DP, Elsbernd BL, Goldstein JL, Brown MS, Zhao TJ. Profound hypoglycemia in starved, ghrelin-deficient mice is caused by decreased gluconeogenesis and reversed by lactate or fatty acids. The Journal of Biological Chemistry. 287: 17942-50. PMID 22474325 DOI: 10.1074/jbc.M112.358051 |
0.405 |
|
| 2012 |
Moon YA, Liang G, Xie X, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V, Brown MS, Goldstein JL, Horton JD. The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals. Cell Metabolism. 15: 240-6. PMID 22326225 DOI: 10.1016/j.cmet.2011.12.017 |
0.459 |
|
| 2012 |
Sherbet DP, Zhao T, Li RL, Brown MS, Goldstein JL. The ghrelin-growth hormone axis preserves gluconeogenesis to maintain blood glucose levels during starvation Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S3-P65 |
0.394 |
|
| 2011 |
Xie X, Brown MS, Shelton JM, Richardson JA, Goldstein JL, Liang G. Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice. Proceedings of the National Academy of Sciences of the United States of America. 108: 15330-5. PMID 21896731 DOI: 10.1073/pnas.1112751108 |
0.552 |
|
| 2011 |
Goldstein JL, Zhao TJ, Li RL, Sherbet DP, Liang G, Brown MS. Surviving starvation: essential role of the ghrelin-growth hormone axis. Cold Spring Harbor Symposia On Quantitative Biology. 76: 121-7. PMID 21785007 DOI: 10.1101/sqb.2011.76.010447 |
0.401 |
|
| 2011 |
Brown MS, Goldstein JL. Richard G.W. Anderson (1940-2011) and the birth of receptor-mediated endocytosis. The Journal of Cell Biology. 193: 601-3. PMID 21576388 DOI: 10.1083/jcb.201104136 |
0.406 |
|
| 2011 |
Motamed M, Zhang Y, Wang ML, Seemann J, Kwon HJ, Goldstein JL, Brown MS. Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis. The Journal of Biological Chemistry. 286: 18002-12. PMID 21454655 DOI: 10.1074/jbc.M111.238311 |
0.579 |
|
| 2010 |
Zhao TJ, Sakata I, Li RL, Liang G, Richardson JA, Brown MS, Goldstein JL, Zigman JM. Ghrelin secretion stimulated by {beta}1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 15868-73. PMID 20713709 DOI: 10.1073/Pnas.1011116107 |
0.457 |
|
| 2010 |
Wang ML, Motamed M, Infante RE, Abi-Mosleh L, Kwon HJ, Brown MS, Goldstein JL. Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomes. Cell Metabolism. 12: 166-73. PMID 20674861 DOI: 10.1016/j.cmet.2010.05.016 |
0.523 |
|
| 2010 |
Brown MS, Ye J, Goldstein JL. Medicine. HDL miR-ed down by SREBP introns. Science (New York, N.Y.). 328: 1495-6. PMID 20558698 DOI: 10.1126/Science.1192409 |
0.635 |
|
| 2010 |
Goldstein J, Brown M. Joseph Goldstein and Michael Brown: demoting egos, promoting success. Interview by Ruth Williams Circulation Research. 106: 1006-1010. PMID 20360260 DOI: 10.1161/RES.0b013e3181dcab4d |
0.371 |
|
| 2010 |
Zhao TJ, Liang G, Li RL, Xie X, Sleeman MW, Murphy AJ, Valenzuela DM, Yancopoulos GD, Goldstein JL, Brown MS. Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 7467-72. PMID 20231469 DOI: 10.1073/pnas.1002271107 |
0.404 |
|
| 2010 |
Li S, Brown MS, Goldstein JL. Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proceedings of the National Academy of Sciences of the United States of America. 107: 3441-6. PMID 20133650 DOI: 10.1073/pnas.0914798107 |
0.398 |
|
| 2010 |
Evers BM, Farooqi MS, Shelton JM, Richardson JA, Goldstein JL, Brown MS, Liang G. Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin. The Journal of Investigative Dermatology. 130: 1237-48. PMID 20090767 DOI: 10.1038/jid.2009.442 |
0.462 |
|
| 2010 |
Okazaki H, Goldstein JL, Brown MS, Liang G. LXR-SREBP-1c-phospholipid transfer protein axis controls very low density lipoprotein (VLDL) particle size. The Journal of Biological Chemistry. 285: 6801-10. PMID 20037162 DOI: 10.1074/jbc.M109.079459 |
0.521 |
|
| 2010 |
Radhakrishnan A, Sun LP, Espenshade PJ, Goldstein JL, Brown MS. The SREBP pathway. gene regulation through sterol sensing and gated protein trafficking Handbook of Cell Signaling, 2/E. 3: 2505-2510. DOI: 10.1016/B978-0-12-374145-5.00298-9 |
0.354 |
|
| 2009 |
Abi-Mosleh L, Infante RE, Radhakrishnan A, Goldstein JL, Brown MS. Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 19316-21. PMID 19884502 DOI: 10.1073/Pnas.0910916106 |
0.58 |
|
| 2009 |
Ikeda Y, Demartino GN, Brown MS, Lee JN, Goldstein JL, Ye J. Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes. The Journal of Biological Chemistry. 284: 34889-900. PMID 19815544 DOI: 10.1074/Jbc.M109.044875 |
0.62 |
|
| 2009 |
Guan HP, Goldstein JL, Brown MS, Liang G. Accelerated fatty acid oxidation in muscle averts fasting-induced hepatic steatosis in SJL/J mice. The Journal of Biological Chemistry. 284: 24644-52. PMID 19581301 DOI: 10.1074/jbc.M109.034397 |
0.401 |
|
| 2009 |
Kwon HJ, Abi-Mosleh L, Wang ML, Deisenhofer J, Goldstein JL, Brown MS, Infante RE. Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol. Cell. 137: 1213-24. PMID 19563754 DOI: 10.1016/J.Cell.2009.03.049 |
0.568 |
|
| 2009 |
Goldstein JL, Brown MS. The LDL receptor. Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 431-8. PMID 19299327 DOI: 10.1161/ATVBAHA.108.179564 |
0.532 |
|
| 2009 |
Brown MS, Goldstein JL. Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL. Journal of Lipid Research. 50: S15-27. PMID 18974038 DOI: 10.1194/jlr.R800054-JLR200 |
0.553 |
|
| 2009 |
Brown MS, Goldstein JL. Erratum: Cholesterol feedback: From Schoenheimer's bottle to Scap's MELADL (Journal of Lipid Research (2009) 50 (S15-S27)) Journal of Lipid Research. 50. DOI: 10.1194/Jlr.Volume50Omission |
0.43 |
|
| 2009 |
BROWN MS, GOLDSTEIN JL. Familial Hypercholesterolemia: Defective Binding of Lipoproteins to Cultured Fibroblasts Associated with Impaired Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity Nutrition Reviews. 43: 279-282. DOI: 10.1111/J.1753-4887.1985.TB02449.X |
0.476 |
|
| 2009 |
Infante R, Wang M, Radhakrishnan A, Kwon H, Brown M, Goldstein J. 69. NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a potential step in cholesterol egress from lysosomes Molecular Genetics and Metabolism. 96: S27. DOI: 10.1016/J.Ymgme.2008.11.070 |
0.563 |
|
| 2008 |
Radhakrishnan A, Goldstein JL, McDonald JG, Brown MS. Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance. Cell Metabolism. 8: 512-21. PMID 19041766 DOI: 10.1016/J.Cmet.2008.10.008 |
0.546 |
|
| 2008 |
Infante RE, Wang ML, Radhakrishnan A, Kwon HJ, Brown MS, Goldstein JL. NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes. Proceedings of the National Academy of Sciences of the United States of America. 105: 15287-92. PMID 18772377 DOI: 10.1073/Pnas.0807328105 |
0.572 |
|
| 2008 |
Yang J, Zhao TJ, Goldstein JL, Brown MS. Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides. Proceedings of the National Academy of Sciences of the United States of America. 105: 10750-5. PMID 18669668 DOI: 10.1073/pnas.0805353105 |
0.424 |
|
| 2008 |
Goldstein JL, Brown MS. From fatty streak to fatty liver: 33 years of joint publications in the JCI. The Journal of Clinical Investigation. 118: 1220-2. PMID 18382725 DOI: 10.1172/JCI34973 |
0.419 |
|
| 2008 |
Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell. 132: 387-96. PMID 18267071 DOI: 10.1016/J.Cell.2008.01.017 |
0.448 |
|
| 2008 |
Brown MS, Goldstein JL. Selective versus total insulin resistance: a pathogenic paradox. Cell Metabolism. 7: 95-6. PMID 18249166 DOI: 10.1016/j.cmet.2007.12.009 |
0.378 |
|
| 2008 |
Infante RE, Abi-Mosleh L, Radhakrishnan A, Dale JD, Brown MS, Goldstein JL. Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein. The Journal of Biological Chemistry. 283: 1052-63. PMID 17989073 DOI: 10.1074/Jbc.M707943200 |
0.555 |
|
| 2008 |
Infante RE, Radhakrishnan A, Abi-Mosleh L, Kinch LN, Wang ML, Grishin NV, Goldstein JL, Brown MS. Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop. The Journal of Biological Chemistry. 283: 1064-75. PMID 17989072 DOI: 10.1074/Jbc.M707944200 |
0.547 |
|
| 2007 |
Radhakrishnan A, Ikeda Y, Kwon HJ, Brown MS, Goldstein JL. Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig. Proceedings of the National Academy of Sciences of the United States of America. 104: 6511-8. PMID 17428920 DOI: 10.1073/Pnas.0700899104 |
0.53 |
|
| 2007 |
Sun LP, Seemann J, Goldstein JL, Brown MS. Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins. Proceedings of the National Academy of Sciences of the United States of America. 104: 6519-26. PMID 17428919 DOI: 10.1073/pnas.0700907104 |
0.518 |
|
| 2007 |
Goldstein JL. The Central Role of Insig Proteins in Regulating Cholesterol Homeostasis The Faseb Journal. 21. DOI: 10.1096/FASEBJ.21.5.A146-F |
0.392 |
|
| 2006 |
Engelking LJ, Evers BM, Richardson JA, Goldstein JL, Brown MS, Liang G. Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin. The Journal of Clinical Investigation. 116: 2356-65. PMID 16955138 DOI: 10.1172/JCI28988 |
0.477 |
|
| 2006 |
Gong Y, Lee JN, Brown MS, Goldstein JL, Ye J. Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 103: 6154-9. PMID 16606821 DOI: 10.1073/Pnas.0601923103 |
0.664 |
|
| 2006 |
Brown MS, Goldstein JL. Biomedicine. Lowering LDL--not only how low, but how long? Science (New York, N.Y.). 311: 1721-3. PMID 16556829 DOI: 10.1126/science.1125884 |
0.472 |
|
| 2006 |
Goldstein JL, DeBose-Boyd RA, Brown MS. Protein sensors for membrane sterols. Cell. 124: 35-46. PMID 16413480 DOI: 10.1016/j.cell.2005.12.022 |
0.477 |
|
| 2006 |
Gong Y, Lee JN, Lee PC, Goldstein JL, Brown MS, Ye J. Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake. Cell Metabolism. 3: 15-24. PMID 16399501 DOI: 10.1016/J.Cmet.2005.11.014 |
0.652 |
|
| 2005 |
Engelking LJ, Liang G, Hammer RE, Takaishi K, Kuriyama H, Evers BM, Li WP, Horton JD, Goldstein JL, Brown MS. Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. The Journal of Clinical Investigation. 115: 2489-98. PMID 16100574 DOI: 10.1172/JCI25614 |
0.539 |
|
| 2005 |
Kuriyama H, Liang G, Engelking LJ, Horton JD, Goldstein JL, Brown MS. Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver. Cell Metabolism. 1: 41-51. PMID 16054043 DOI: 10.1016/j.cmet.2004.11.004 |
0.458 |
|
| 2005 |
Sun LP, Li L, Goldstein JL, Brown MS. Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro. The Journal of Biological Chemistry. 280: 26483-90. PMID 15899885 DOI: 10.1074/jbc.M504041200 |
0.526 |
|
| 2005 |
Wang C, Gale M, Keller BC, Huang H, Brown MS, Goldstein JL, Ye J. Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. Molecular Cell. 18: 425-34. PMID 15893726 DOI: 10.1016/J.Molcel.2005.04.004 |
0.546 |
|
| 2005 |
Feramisco JD, Radhakrishnan A, Ikeda Y, Reitz J, Brown MS, Goldstein JL. Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change. Proceedings of the National Academy of Sciences of the United States of America. 102: 3242-7. PMID 15728349 DOI: 10.1073/Pnas.0500206102 |
0.562 |
|
| 2005 |
Brown M, Flier J, Friedman J, Goldstein J, Kahn CR, Lifton R, O'Rahilly S, Spiegelman B. Cell Metabolism: Why, and why now? Cell Metabolism. 1: 3. DOI: 10.1016/J.Cmet.2004.12.007 |
0.54 |
|
| 2004 |
Bilheimer DW, Grundy SM, Brown MS, Goldstein JL. Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholeserolemia heterozygotes. 1983. Atherosclerosis. Supplements. 5: 61-5. PMID 15531277 DOI: 10.1016/j.atherosclerosissup.2004.08.025 |
0.549 |
|
| 2004 |
Brown MS, Goldstein JL. Lowering plasma cholesterol by raising ldl receptors. 1981. Atherosclerosis. Supplements. 5: 57-9. PMID 15531276 DOI: 10.1016/j.atherosclerosissup.2004.08.024 |
0.528 |
|
| 2004 |
Adams CM, Reitz J, De Brabander JK, Feramisco JD, Li L, Brown MS, Goldstein JL. Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs. The Journal of Biological Chemistry. 279: 52772-80. PMID 15452130 DOI: 10.1074/jbc.M410302200 |
0.578 |
|
| 2004 |
Chen G, Liang G, Ou J, Goldstein JL, Brown MS. Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Proceedings of the National Academy of Sciences of the United States of America. 101: 11245-50. PMID 15266058 DOI: 10.1073/pnas.0404297101 |
0.477 |
|
| 2004 |
Radhakrishnan A, Sun LP, Kwon HJ, Brown MS, Goldstein JL. Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain. Molecular Cell. 15: 259-68. PMID 15260976 DOI: 10.1016/J.Molcel.2004.06.019 |
0.547 |
|
| 2004 |
Engelking LJ, Kuriyama H, Hammer RE, Horton JD, Brown MS, Goldstein JL, Liang G. Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis. The Journal of Clinical Investigation. 113: 1168-75. PMID 15085196 DOI: 10.1172/JCI20978 |
0.56 |
|
| 2004 |
Feramisco JD, Goldstein JL, Brown MS. Membrane topology of human insig-1, a protein regulator of lipid synthesis. The Journal of Biological Chemistry. 279: 8487-96. PMID 14660594 DOI: 10.1074/jbc.M312623200 |
0.53 |
|
| 2004 |
Brown MS, Goldstein JL. A tribute to Akira Endo, discoverer of a “Penicillin” for cholesterol Atherosclerosis Supplements. 5: 13-16. DOI: 10.1016/J.ATHEROSCLEROSISSUP.2004.08.007 |
0.505 |
|
| 2003 |
Ye J, Wang C, Sumpter R, Brown MS, Goldstein JL, Gale M. Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation. Proceedings of the National Academy of Sciences of the United States of America. 100: 15865-70. PMID 14668447 DOI: 10.1073/Pnas.2237238100 |
0.54 |
|
| 2003 |
Sever N, Song BL, Yabe D, Goldstein JL, Brown MS, DeBose-Boyd RA. Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. The Journal of Biological Chemistry. 278: 52479-90. PMID 14563840 DOI: 10.1074/jbc.M310053200 |
0.495 |
|
| 2003 |
Horton JD, Shah NA, Warrington JA, Anderson NN, Park SW, Brown MS, Goldstein JL. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proceedings of the National Academy of Sciences of the United States of America. 100: 12027-32. PMID 14512514 DOI: 10.1073/pnas.1534923100 |
0.48 |
|
| 2003 |
Adams CM, Goldstein JL, Brown MS. Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles. Proceedings of the National Academy of Sciences of the United States of America. 100: 10647-52. PMID 12963821 DOI: 10.1073/pnas.1534833100 |
0.544 |
|
| 2003 |
Dobrosotskaya IY, Goldstein JL, Brown MS, Rawson RB. Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs. The Journal of Biological Chemistry. 278: 35837-43. PMID 12842885 DOI: 10.1074/jbc.M306476200 |
0.473 |
|
| 2003 |
Kasus-Jacobi A, Ou J, Bashmakov YK, Shelton JM, Richardson JA, Goldstein JL, Brown MS. Characterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteins. The Journal of Biological Chemistry. 278: 32380-9. PMID 12807874 DOI: 10.1074/jbc.M304969200 |
0.486 |
|
| 2003 |
Yabe D, Komuro R, Liang G, Goldstein JL, Brown MS. Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis. Proceedings of the National Academy of Sciences of the United States of America. 100: 3155-60. PMID 12624180 DOI: 10.1073/pnas.0130116100 |
0.492 |
|
| 2003 |
Sever N, Yang T, Brown MS, Goldstein JL, DeBose-Boyd RA. Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. Molecular Cell. 11: 25-33. PMID 12535518 DOI: 10.1016/S1097-2765(02)00822-5 |
0.517 |
|
| 2003 |
Horton J, Brown M, Goldstein J. 1SY01-4 Activators or inhibitors of SREBPs for the treatment of hypercholesterolemia Atherosclerosis Supplements. 4: 3. DOI: 10.1016/S1567-5688(03)90016-X |
0.377 |
|
| 2003 |
Espenshade PJ, Goldstein JL, Brown MS. SREPBs: Gene Regulation through Controlled Protein Trafficking Handbook of Cell Signaling. 3: 353-358. DOI: 10.1016/B978-012124546-7/50686-0 |
0.34 |
|
| 2002 |
Horton JD, Goldstein JL, Brown MS. SREBPs: transcriptional mediators of lipid homeostasis. Cold Spring Harbor Symposia On Quantitative Biology. 67: 491-8. PMID 12858575 DOI: 10.1101/Sqb.2002.67.491 |
0.48 |
|
| 2002 |
Goldstein JL, Brown MS. Acceptance remarks of Joseph L Goldstein and Michael S. Brown on the occasion of the presentation of the Kober Medal, 2002. The Journal of Clinical Investigation. 110: S11-3. PMID 12506883 DOI: 10.1172/Jci120038 |
0.343 |
|
| 2002 |
Rudenko G, Henry L, Henderson K, Ichtchenko K, Brown MS, Goldstein JL, Deisenhofer J. Structure of the LDL receptor extracellular domain at endosomal pH. Science (New York, N.Y.). 298: 2353-8. PMID 12459547 DOI: 10.1126/Science.1078124 |
0.491 |
|
| 2002 |
Yabe D, Brown MS, Goldstein JL. Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proceedings of the National Academy of Sciences of the United States of America. 99: 12753-8. PMID 12242332 DOI: 10.1073/pnas.162488899 |
0.522 |
|
| 2002 |
Yang T, Espenshade PJ, Wright ME, Yabe D, Gong Y, Aebersold R, Goldstein JL, Brown MS. Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell. 110: 489-500. PMID 12202038 DOI: 10.1016/S0092-8674(02)00872-3 |
0.534 |
|
| 2002 |
Brown AJ, Sun L, Feramisco JD, Brown MS, Goldstein JL. Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism. Molecular Cell. 10: 237-45. PMID 12191470 DOI: 10.1016/S1097-2765(02)00591-9 |
0.546 |
|
| 2002 |
Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. The Journal of Clinical Investigation. 109: 1125-31. PMID 11994399 DOI: 10.1172/JCI15593 |
0.544 |
|
| 2002 |
Dobrosotskaya IY, Seegmiller AC, Brown MS, Goldstein JL, Rawson RB. Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila. Science (New York, N.Y.). 296: 879-83. PMID 11988566 DOI: 10.1126/science.1071124 |
0.49 |
|
| 2002 |
Seegmiller AC, Dobrosotskaya I, Goldstein JL, Ho YK, Brown MS, Rawson RB. The SREBP pathway in Drosophila: regulation by palmitate, not sterols. Developmental Cell. 2: 229-38. PMID 11832248 DOI: 10.1016/S1534-5807(01)00119-8 |
0.516 |
|
| 2002 |
Goldstein JL, Rawson RB, Brown MS. Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis. Archives of Biochemistry and Biophysics. 397: 139-48. PMID 11795864 DOI: 10.1006/abbi.2001.2615 |
0.546 |
|
| 2002 |
Liang G, Yang J, Horton JD, Hammer RE, Goldstein JL, Brown MS. Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c. The Journal of Biological Chemistry. 277: 9520-8. PMID 11782483 DOI: 10.1074/jbc.M111421200 |
0.487 |
|
| 2001 |
Yang J, Goldstein JL, Hammer RE, Moon YA, Brown MS, Horton JD. Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene. Proceedings of the National Academy of Sciences of the United States of America. 98: 13607-12. PMID 11717426 DOI: 10.1073/pnas.201524598 |
0.541 |
|
| 2001 |
Ou J, Tu H, Shan B, Luk A, DeBose-Boyd RA, Bashmakov Y, Goldstein JL, Brown MS. Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR. Proceedings of the National Academy of Sciences of the United States of America. 98: 6027-32. PMID 11371634 DOI: 10.1073/pnas.111138698 |
0.495 |
|
| 2001 |
Goldstein JL, Brown MS. Molecular medicine. The cholesterol quartet. Science (New York, N.Y.). 292: 1310-2. PMID 11360986 DOI: 10.1126/science.1061815 |
0.547 |
|
| 2001 |
Matsuda M, Korn BS, Hammer RE, Moon YA, Komuro R, Horton JD, Goldstein JL, Brown MS, Shimomura I. SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. Genes & Development. 15: 1206-16. PMID 11358865 DOI: 10.1101/gad.891301 |
0.556 |
|
| 2001 |
Zhang J, Ou J, Bashmakov Y, Horton JD, Brown MS, Goldstein JL. Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes. Proceedings of the National Academy of Sciences of the United States of America. 98: 3756-61. PMID 11259670 DOI: 10.1073/pnas.071054598 |
0.404 |
|
| 2001 |
DeBose-Boyd RA, Ou J, Goldstein JL, Brown MS. Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands. Proceedings of the National Academy of Sciences of the United States of America. 98: 1477-82. PMID 11171976 DOI: 10.1073/pnas.98.4.1477 |
0.516 |
|
| 2001 |
Hannah VC, Ou J, Luong A, Goldstein JL, Brown MS. Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells. The Journal of Biological Chemistry. 276: 4365-72. PMID 11085986 DOI: 10.1074/jbc.M007273200 |
0.475 |
|
| 2000 |
Ye J, Rawson RB, Komuro R, Chen X, Davé UP, Prywes R, Brown MS, Goldstein JL. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Molecular Cell. 6: 1355-64. PMID 11163209 DOI: 10.1016/S1097-2765(00)00133-7 |
0.589 |
|
| 2000 |
Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, Shan B, Brown MS, Goldstein JL, Mangelsdorf DJ. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes & Development. 14: 2819-30. PMID 11090130 DOI: 10.1101/gad.844900 |
0.542 |
|
| 2000 |
Nohturfft A, Yabe D, Goldstein JL, Brown MS, Espenshade PJ. Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes. Cell. 102: 315-23. PMID 10975522 DOI: 10.1016/S0092-8674(00)00037-4 |
0.506 |
|
| 2000 |
Shimomura I, Matsuda M, Hammer RE, Bashmakov Y, Brown MS, Goldstein JL. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Molecular Cell. 6: 77-86. PMID 10949029 DOI: 10.1016/S1097-2765(05)00010-9 |
0.395 |
|
| 2000 |
Yang T, Goldstein JL, Brown MS. Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum. The Journal of Biological Chemistry. 275: 29881-6. PMID 10896675 DOI: 10.1074/jbc.M005439200 |
0.499 |
|
| 2000 |
Luong A, Hannah VC, Brown MS, Goldstein JL. Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins. The Journal of Biological Chemistry. 275: 26458-66. PMID 10843999 DOI: 10.1074/jbc.M004160200 |
0.496 |
|
| 2000 |
Ye J, Davé UP, Grishin NV, Goldstein JL, Brown MS. Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease. Proceedings of the National Academy of Sciences of the United States of America. 97: 5123-8. PMID 10805775 DOI: 10.1073/Pnas.97.10.5123 |
0.6 |
|
| 2000 |
Brown MS, Ye J, Rawson RB, Goldstein JL. Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell. 100: 391-8. PMID 10693756 DOI: 10.1016/S0092-8674(00)80675-3 |
0.551 |
|
| 2000 |
Shimomura I, Hammer RE, Ikemoto S, Brown MS, Goldstein JL. reply: Leptin and diabetes in lipoatrophic mice Nature. 403: 850-851. DOI: 10.1038/35002667 |
0.375 |
|
| 1999 |
DeBose-Boyd RA, Brown MS, Li WP, Nohturfft A, Goldstein JL, Espenshade PJ. Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi. Cell. 99: 703-12. PMID 10619424 DOI: 10.1016/S0092-8674(00)81668-2 |
0.495 |
|
| 1999 |
Shimomura I, Bashmakov Y, Ikemoto S, Horton JD, Brown MS, Goldstein JL. Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. Proceedings of the National Academy of Sciences of the United States of America. 96: 13656-61. PMID 10570128 DOI: 10.1073/pnas.96.24.13656 |
0.451 |
|
| 1999 |
Nohturfft A, DeBose-Boyd RA, Scheek S, Goldstein JL, Brown MS. Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi. Proceedings of the National Academy of Sciences of the United States of America. 96: 11235-40. PMID 10500160 DOI: 10.1073/Pnas.96.20.11235 |
0.505 |
|
| 1999 |
Brown MS, Goldstein JL. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proceedings of the National Academy of Sciences of the United States of America. 96: 11041-8. PMID 10500120 DOI: 10.1073/Pnas.96.20.11041 |
0.536 |
|
| 1999 |
Rawson RB, DeBose-Boyd R, Goldstein JL, Brown MS. Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein. The Journal of Biological Chemistry. 274: 28549-56. PMID 10497220 DOI: 10.1074/Jbc.274.40.28549 |
0.55 |
|
| 1999 |
Shimomura I, Hammer RE, Ikemoto S, Brown MS, Goldstein JL. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature. 401: 73-6. PMID 10485707 DOI: 10.1038/43448 |
0.415 |
|
| 1999 |
Cheng D, Espenshade PJ, Slaughter CA, Jaen JC, Brown MS, Goldstein JL. Secreted site-1 protease cleaves peptides corresponding to luminal loop of sterol regulatory element-binding proteins. The Journal of Biological Chemistry. 274: 22805-12. PMID 10428865 DOI: 10.1074/Jbc.274.32.22805 |
0.491 |
|
| 1999 |
Espenshade PJ, Cheng D, Goldstein JL, Brown MS. Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins. The Journal of Biological Chemistry. 274: 22795-804. PMID 10428864 DOI: 10.1074/Jbc.274.32.22795 |
0.483 |
|
| 1999 |
Zelenski NG, Rawson RB, Brown MS, Goldstein JL. Membrane topology of S2P, a protein required for intramembranous cleavage of sterol regulatory element-binding proteins. The Journal of Biological Chemistry. 274: 21973-80. PMID 10419520 DOI: 10.1074/Jbc.274.31.21973 |
0.488 |
|
| 1999 |
Lanza RP, Arrow KJ, Axelrod J, Baltimore D, Benacerraf B, Bloch KE, Bloembergen N, Brown HC, Brown MS, Cibelli JB, Cohen S, Cooper LN, Corey EJ, Dulbecco R, Fischer EH, ... ... Goldstein JL, et al. Science over politics. Science (New York, N.Y.). 283: 1849-50. PMID 10206888 DOI: 10.1126/Science.283.5409.1849B |
0.383 |
|
| 1999 |
Horton JD, Shimano H, Hamilton RL, Brown MS, Goldstein JL. Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL. The Journal of Clinical Investigation. 103: 1067-76. PMID 10194480 DOI: 10.1172/JCI6246 |
0.532 |
|
| 1999 |
Horton J, Shimano H, Hamilton R, Brown M, Goldstein J. Disruption of the LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia and atherosclerosis resulting from the production of lipid-rich VLDL Atherosclerosis. 144: 165. DOI: 10.1016/S0021-9150(99)80632-7 |
0.497 |
|
| 1999 |
Horton J, Shimano H, Shimomura I, Hammer R, Brown M, Goldstein J. SREBPs: Activators of cholesterol and monounsaturated fatty acid synthesis Atherosclerosis. 144: 10. DOI: 10.1016/S0021-9150(99)80031-8 |
0.485 |
|
| 1998 |
Korn BS, Shimomura I, Bashmakov Y, Hammer RE, Horton JD, Goldstein JL, Brown MS. Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N). The Journal of Clinical Investigation. 102: 2050-60. PMID 9854040 DOI: 10.1172/JCI5341 |
0.537 |
|
| 1998 |
Sakai J, Rawson RB, Espenshade PJ, Cheng D, Seegmiller AC, Goldstein JL, Brown MS. Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells. Molecular Cell. 2: 505-14. PMID 9809072 DOI: 10.1016/S1097-2765(00)80150-1 |
0.514 |
|
| 1998 |
Nohturfft A, Brown MS, Goldstein JL. Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N. Proceedings of the National Academy of Sciences of the United States of America. 95: 12848-53. PMID 9789003 DOI: 10.1073/Pnas.95.22.12848 |
0.52 |
|
| 1998 |
Shimomura I, Hammer RE, Richardson JA, Ikemoto S, Bashmakov Y, Goldstein JL, Brown MS. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes & Development. 12: 3182-94. PMID 9784493 DOI: 10.1101/Gad.12.20.3182 |
0.443 |
|
| 1998 |
Rawson RB, Cheng D, Brown MS, Goldstein JL. Isolation of cholesterol-requiring mutant Chinese hamster ovary cells with defects in cleavage of sterol regulatory element-binding proteins at site 1. The Journal of Biological Chemistry. 273: 28261-9. PMID 9774448 DOI: 10.1074/Jbc.273.43.28261 |
0.533 |
|
| 1998 |
Pai JT, Guryev O, Brown MS, Goldstein JL. Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins. The Journal of Biological Chemistry. 273: 26138-48. PMID 9748295 DOI: 10.1074/Jbc.273.40.26138 |
0.542 |
|
| 1998 |
Duncan EA, Davé UP, Sakai J, Goldstein JL, Brown MS. Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning. The Journal of Biological Chemistry. 273: 17801-9. PMID 9651382 DOI: 10.1074/Jbc.273.28.17801 |
0.476 |
|
| 1998 |
Nohturfft A, Brown MS, Goldstein JL. Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain. The Journal of Biological Chemistry. 273: 17243-50. PMID 9642295 DOI: 10.1074/Jbc.273.27.17243 |
0.474 |
|
| 1998 |
Horton JD, Shimomura I, Brown MS, Hammer RE, Goldstein JL, Shimano H. Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. The Journal of Clinical Investigation. 101: 2331-9. PMID 9616204 DOI: 10.1172/JCI2961 |
0.527 |
|
| 1998 |
Brown MS, Goldstein JL. Sterol regulatory element binding proteins (SREBPs): controllers of lipid synthesis and cellular uptake. Nutrition Reviews. 56: S1-3; discussion S54. PMID 9564170 DOI: 10.1111/J.1753-4887.1998.Tb01680.X |
0.575 |
|
| 1998 |
Sakai J, Nohturfft A, Goldstein JL, Brown MS. Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies. The Journal of Biological Chemistry. 273: 5785-93. PMID 9488713 DOI: 10.1074/Jbc.273.10.5785 |
0.493 |
|
| 1997 |
Rawson RB, Zelenski NG, Nijhawan D, Ye J, Sakai J, Hasan MT, Chang TY, Brown MS, Goldstein JL. Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs. Molecular Cell. 1: 47-57. PMID 9659902 DOI: 10.1016/S1097-2765(00)80006-4 |
0.637 |
|
| 1997 |
Shimomura I, Bashmakov Y, Shimano H, Horton JD, Goldstein JL, Brown MS. Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver. Proceedings of the National Academy of Sciences of the United States of America. 94: 12354-9. PMID 9356453 DOI: 10.1073/Pnas.94.23.12354 |
0.584 |
|
| 1997 |
Shimano H, Shimomura I, Hammer RE, Herz J, Goldstein JL, Brown MS, Horton JD. Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. The Journal of Clinical Investigation. 100: 2115-24. PMID 9329978 DOI: 10.1172/Jci119746 |
0.642 |
|
| 1997 |
Scheek S, Brown MS, Goldstein JL. Sphingomyelin depletion in cultured cells blocks proteolysis of sterol regulatory element binding proteins at site 1. Proceedings of the National Academy of Sciences of the United States of America. 94: 11179-83. PMID 9326582 DOI: 10.1073/Pnas.94.21.11179 |
0.558 |
|
| 1997 |
Brown MS, Herz J, Goldstein JL. LDL-receptor structure. Calcium cages, acid baths and recycling receptors. Nature. 388: 629-30. PMID 9262394 DOI: 10.1038/41672 |
0.597 |
|
| 1997 |
Sakai J, Nohturfft A, Cheng D, Ho YK, Brown MS, Goldstein JL. Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein. The Journal of Biological Chemistry. 272: 20213-21. PMID 9242699 DOI: 10.1074/Jbc.272.32.20213 |
0.49 |
|
| 1997 |
Goldstein JL, Brown MS. The clinical investigator: bewitched, bothered, and bewildered--but still beloved. The Journal of Clinical Investigation. 99: 2803-12. PMID 9185499 DOI: 10.1172/JCI119470 |
0.334 |
|
| 1997 |
Brown MS, Goldstein JL. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell. 89: 331-40. PMID 9150132 DOI: 10.1016/S0092-8674(00)80213-5 |
0.468 |
|
| 1997 |
Duncan EA, Brown MS, Goldstein JL, Sakai J. Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2. The Journal of Biological Chemistry. 272: 12778-85. PMID 9139737 DOI: 10.1074/Jbc.272.19.12778 |
0.525 |
|
| 1997 |
Shimano H, Horton JD, Shimomura I, Hammer RE, Brown MS, Goldstein JL. Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. The Journal of Clinical Investigation. 99: 846-54. PMID 9062341 DOI: 10.1172/JCI119248 |
0.501 |
|
| 1997 |
Shimomura I, Shimano H, Horton JD, Goldstein JL, Brown MS. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. The Journal of Clinical Investigation. 99: 838-45. PMID 9062340 DOI: 10.1172/JCI119247 |
0.431 |
|
| 1996 |
Nohturfft A, Hua X, Brown MS, Goldstein JL. Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines. Proceedings of the National Academy of Sciences of the United States of America. 93: 13709-14. PMID 8942999 DOI: 10.1073/Pnas.93.24.13709 |
0.5 |
|
| 1996 |
Hua X, Nohturfft A, Goldstein JL, Brown MS. Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein. Cell. 87: 415-26. PMID 8898195 DOI: 10.1016/S0092-8674(00)81362-8 |
0.524 |
|
| 1996 |
Shimano H, Horton JD, Hammer RE, Shimomura I, Brown MS, Goldstein JL. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. The Journal of Clinical Investigation. 98: 1575-84. PMID 8833906 DOI: 10.1172/JCI118951 |
0.541 |
|
| 1996 |
Sakai J, Duncan EA, Rawson RB, Hua X, Brown MS, Goldstein JL. Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment. Cell. 85: 1037-46. PMID 8674110 DOI: 10.1016/S0092-8674(00)81304-5 |
0.507 |
|
| 1996 |
Cao G, Goldstein JL, Brown MS. Complementation of mutation in acyl-CoA:cholesterol acyltransferase (ACAT) fails to restore sterol regulation in ACAT-defective sterol-resistant hamster cells. The Journal of Biological Chemistry. 271: 14642-8. PMID 8662991 DOI: 10.1074/Jbc.271.24.14642 |
0.531 |
|
| 1996 |
Breslow JI, Brown MS, Goldstein JL, Labarthe DR. Battling Heart Disease Science. 273: 15-16. PMID 8658181 DOI: 10.1126/Science.273.5271.15A |
0.389 |
|
| 1996 |
Pai JT, Brown MS, Goldstein JL. Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins. Proceedings of the National Academy of Sciences of the United States of America. 93: 5437-42. PMID 8643593 DOI: 10.1073/Pnas.93.11.5437 |
0.519 |
|
| 1996 |
James G, Goldstein JL, Brown MS. Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells. Proceedings of the National Academy of Sciences of the United States of America. 93: 4454-8. PMID 8633088 DOI: 10.1073/Pnas.93.9.4454 |
0.391 |
|
| 1996 |
Hua X, Sakai J, Brown MS, Goldstein JL. Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane. The Journal of Biological Chemistry. 271: 10379-84. PMID 8626610 DOI: 10.1074/Jbc.271.17.10379 |
0.552 |
|
| 1996 |
Brown MS, Goldstein JL. Heart attacks: gone with the century? Science (New York, N.Y.). 272: 629. PMID 8614809 DOI: 10.1126/Science.272.5262.629 |
0.519 |
|
| 1996 |
Wang X, Zelenski NG, Yang J, Sakai J, Brown MS, Goldstein JL. Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. The Embo Journal. 15: 1012-20. PMID 8605870 DOI: 10.1002/J.1460-2075.1996.Tb00438.X |
0.554 |
|
| 1996 |
James GL, Brown MS, Goldstein JL. Assays for inhibitors of CAAX farnesyltransferase in vitro and in intact cells. Methods in Enzymology. 255: 38-46. PMID 8524124 DOI: 10.1016/S0076-6879(95)55007-0 |
0.403 |
|
| 1995 |
Armstrong SA, Brown MS, Goldstein JL, Seabra MC. Preparation of recombinant Rab geranylgeranyltransferase and Rab escort proteins Methods in Enzymology. 257: 30-41. PMID 8583933 DOI: 10.1016/S0076-6879(95)57007-1 |
0.595 |
|
| 1995 |
James GL, Goldstein JL, Brown MS. Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro. The Journal of Biological Chemistry. 270: 6221-6. PMID 7890759 DOI: 10.1074/JBC.270.11.6221 |
0.384 |
|
| 1995 |
Sheng Z, Otani H, Brown MS, Goldstein JL. Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. Proceedings of the National Academy of Sciences of the United States of America. 92: 935-8. PMID 7862668 DOI: 10.1073/PNAS.92.4.935 |
0.567 |
|
| 1995 |
Garcia CK, Brown MS, Pathak RK, Goldstein JL. cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1. The Journal of Biological Chemistry. 270: 1843-9. PMID 7829520 DOI: 10.1074/jbc.270.4.1843 |
0.414 |
|
| 1995 |
Hua X, Wu J, Goldstein JL, Brown MS, Hobbs HH. Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13. Genomics. 25: 667-73. PMID 7759101 DOI: 10.1016/0888-7543(95)80009-B |
0.657 |
|
| 1995 |
Yang J, Brown MS, Ho YK, Goldstein JL. Three different rearrangements in a single intron truncate sterol regulatory element binding protein-2 and produce sterol-resistant phenotype in three cell lines. Role of introns in protein evolution. The Journal of Biological Chemistry. 270: 12152-61. PMID 7744865 DOI: 10.1074/jbc.270.20.12152 |
0.559 |
|
| 1995 |
Armstrong SA, Hannah VC, Goldstein JL, Brown MS. CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB Journal of Biological Chemistry. 270: 7864-7868. PMID 7713879 DOI: 10.1074/Jbc.270.14.7864 |
0.588 |
|
| 1995 |
Frykman PK, Brown MS, Yamamoto T, Goldstein JL, Herz J. Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor. Proceedings of the National Academy of Sciences of the United States of America. 92: 8453-7. PMID 7667310 DOI: 10.1073/Pnas.92.18.8453 |
0.66 |
|
| 1995 |
Wang X, Pai JT, Wiedenfeld EA, Medina JC, Slaughter CA, Goldstein JL, Brown MS. Purification of an interleukin-1 beta converting enzyme-related cysteine protease that cleaves sterol regulatory element-binding proteins between the leucine zipper and transmembrane domains. The Journal of Biological Chemistry. 270: 18044-50. PMID 7629113 DOI: 10.1074/Jbc.270.30.18044 |
0.563 |
|
| 1995 |
Hua X, Sakai J, Ho YK, Goldstein JL, Brown MS. Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection. The Journal of Biological Chemistry. 270: 29422-7. PMID 7493979 DOI: 10.1074/Jbc.270.49.29422 |
0.498 |
|
| 1994 |
Ishibashi S, Herz J, Maeda N, Goldstein JL, Brown MS. The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins. Proceedings of the National Academy of Sciences of the United States of America. 91: 4431-5. PMID 8183926 DOI: 10.1073/Pnas.91.10.4431 |
0.638 |
|
| 1994 |
Ishibashi S, Goldstein JL, Brown MS, Herz J, Burns DK. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. The Journal of Clinical Investigation. 93: 1885-93. PMID 8182121 DOI: 10.1172/Jci117179 |
0.642 |
|
| 1994 |
Wang X, Sato R, Brown MS, Hua X, Goldstein JL. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell. 77: 53-62. PMID 8156598 DOI: 10.1016/0092-8674(94)90234-8 |
0.57 |
|
| 1994 |
Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS. Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle. Cell. 76: 865-73. PMID 8124722 DOI: 10.1016/0092-8674(94)90361-1 |
0.414 |
|
| 1994 |
Sato R, Yang J, Wang X, Evans MJ, Ho YK, Goldstein JL, Brown MS. Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1). The Journal of Biological Chemistry. 269: 17267-73. PMID 8006035 |
0.444 |
|
| 1994 |
Yang J, Sato R, Goldstein JL, Brown MS. Sterol-resistant transcription in CHO cells caused by gene rearrangement that truncates SREBP-2. Genes & Development. 8: 1910-9. PMID 7958866 DOI: 10.1101/GAD.8.16.1910 |
0.523 |
|
| 1994 |
Smeland TE, Seabra MC, Goldstein JL, Brown MS. Geranylgeranylated Rab proteins terminating in Cys-Ala-Cys, but not Cys-Cys, are carboxyl-methylated by bovine brain membranes in vitro. Proceedings of the National Academy of Sciences of the United States of America. 91: 10712-6. PMID 7938016 DOI: 10.1073/PNAS.91.22.10712 |
0.42 |
|
| 1994 |
Brown MS, Goldstein JL, Havel RJ, Steinberg D. Gene therapy for cholesterol [1] Nature Genetics. 7: 349-350. PMID 7920651 DOI: 10.1038/ng0794-349 |
0.46 |
|
| 1994 |
Cremers F, Armstrong S, Seabra M, Brown M, Goldstein J. REP-2, a Rab escort protein encoded by the choroideremia-like gene. Journal of Biological Chemistry. 269: 2111-2117. DOI: 10.1016/s0021-9258(17)42142-9 |
0.336 |
|
| 1994 |
James G, Goldstein J, Pathak R, Anderson R, Brown M. PxF, a prenylated protein of peroxisomes. Journal of Biological Chemistry. 269: 14182-14190. DOI: 10.1016/s0021-9258(17)36772-8 |
0.323 |
|
| 1994 |
Marsters JC, McDowelll RS, Reynolds ME, Somers TC, Goldstein JL, Brown MS, James GL. Peptidomimetic inhibitors of Ras farnesylation Chemistry & Biology. 1: viii-ix. DOI: 10.1016/1074-5521(94)90021-3 |
0.427 |
|
| 1994 |
Ishibashi S, Herz J, Burns D, Hammer R, Gerard R, Brown M, Goldstein J. Low density lipoprotein receptor knockout mouse Pathophysiology. 1: 363. DOI: 10.1016/0928-4680(94)90743-9 |
0.469 |
|
| 1993 |
Andres DA, Seabra MC, Brown MS, Armstrong SA, Smeland TE, Cremers FPM, Goldstein JL. cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein Cell. 73: 1091-1099. PMID 8513495 DOI: 10.1016/0092-8674(93)90639-8 |
0.715 |
|
| 1993 |
Armstrong SA, Seabra MC, Südhof TC, Goldstein JL, Brown MS. cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase. The Journal of Biological Chemistry. 268: 12221-9. PMID 8505342 |
0.615 |
|
| 1993 |
Sato R, Goldstein JL, Brown MS. Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion. Proceedings of the National Academy of Sciences of the United States of America. 90: 9261-5. PMID 8415689 DOI: 10.1073/PNAS.90.20.9261 |
0.466 |
|
| 1993 |
Yokoyama C, Wang X, Briggs MR, Admon A, Wu J, Hua X, Goldstein JL, Brown MS. SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell. 75: 187-97. PMID 8402897 DOI: 10.1016/S0092-8674(05)80095-9 |
0.628 |
|
| 1993 |
Briggs MR, Yokoyama C, Wang X, Brown MS, Goldstein JL. Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence. The Journal of Biological Chemistry. 268: 14490-6. PMID 8390995 |
0.458 |
|
| 1993 |
Seabra MC, Brown MS, Goldstein JL. Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase. Science (New York, N.Y.). 259: 377-81. PMID 8380507 DOI: 10.1126/SCIENCE.8380507 |
0.449 |
|
| 1993 |
Ishibashi S, Brown MS, Goldstein JL, Gerard RD, Hammer RE, Herz J. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. The Journal of Clinical Investigation. 92: 883-93. PMID 8349823 DOI: 10.1172/Jci116663 |
0.666 |
|
| 1993 |
James GL, Goldstein JL, Brown MS, Rawson TE, Somers TC, McDowell RS, Crowley CW, Lucas BK, Levinson AD, Marsters JC. Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells. Science (New York, N.Y.). 260: 1937-42. PMID 8316834 DOI: 10.1126/SCIENCE.8316834 |
0.407 |
|
| 1993 |
Wang X, Briggs MR, Hua X, Yokoyama C, Goldstein JL, Brown MS. Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization. The Journal of Biological Chemistry. 268: 14497-504. PMID 8314806 |
0.478 |
|
| 1993 |
Andres DA, Milatovich A, Ozçelik T, Wenzlau JM, Brown MS, Goldstein JL, Francke U. cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences. Genomics. 18: 105-12. PMID 8276393 DOI: 10.1006/Geno.1993.1432 |
0.635 |
|
| 1993 |
Brown MS, Goldstein JL. Protein prenylation. Mad bet for Rab. Nature. 366: 14-5. PMID 8232528 DOI: 10.1038/366014A0 |
0.41 |
|
| 1993 |
Hua X, Yokoyama C, Wu J, Briggs MR, Brown MS, Goldstein JL, Wang X. SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proceedings of the National Academy of Sciences of the United States of America. 90: 11603-7. PMID 7903453 DOI: 10.1073/Pnas.90.24.11603 |
0.552 |
|
| 1993 |
Hobbs HH, Brown MS, Goldstein JL. Molecular genetics of the LDL receptor gene in familial hypercholesterolemia. Human Mutation. 1: 445-66. PMID 1301956 DOI: 10.1002/HUMU.1380010602 |
0.692 |
|
| 1993 |
Andres D, Goldstein J, Ho Y, Brown M. Mutational analysis of alpha-subunit of protein farnesyltransferase. Evidence for a catalytic role. Journal of Biological Chemistry. 268: 1383-1390. DOI: 10.1016/s0021-9258(18)54087-4 |
0.303 |
|
| 1992 |
Chen WJ, Andres DA, Goldstein JL, Brown MS. Cloning and expression of a cDNA encoding the alpha subunit of rat p21ras protein farnesyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 88: 11368-72. PMID 1763049 DOI: 10.1073/Pnas.88.24.11368 |
0.625 |
|
| 1992 |
Ridgway ND, Dawson PA, Ho YK, Brown MS, Goldstein JL. Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding. The Journal of Cell Biology. 116: 307-19. PMID 1730758 DOI: 10.1083/jcb.116.2.307 |
0.492 |
|
| 1992 |
Goldstein JL, Brown MS. Lipoprotein receptors and the control of plasma LDL cholesterol levels. European Heart Journal. 34-6. PMID 1644100 DOI: 10.1093/EURHEARTJ/13.SUPPL_B.34 |
0.545 |
|
| 1992 |
Yokode M, Pathak RK, Hammer RE, Brown MS, Goldstein JL, Anderson RG. Cytoplasmic sequence required for basolateral targeting of LDL receptor in livers of transgenic mice. The Journal of Cell Biology. 117: 39-46. PMID 1556156 DOI: 10.1083/JCB.117.1.39 |
0.52 |
|
| 1992 |
Seabra MC, Brown MS, Slaughter CA, Südhof TC, Goldstein JL. Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product. Cell. 70: 1049-57. PMID 1525821 DOI: 10.1016/0092-8674(92)90253-9 |
0.569 |
|
| 1992 |
Brown MS, Goldstein JL, Paris KJ, Burnier JP, Marsters JC. Tetrapeptide inhibitors of protein farnesyltransferase: amino-terminal substitution in phenylalanine-containing tetrapeptides restores farnesylation. Proceedings of the National Academy of Sciences of the United States of America. 89: 8313-6. PMID 1518863 DOI: 10.1073/PNAS.89.17.8313 |
0.411 |
|
| 1992 |
Willnow TE, Goldstein JL, Orth K, Brown MS, Herz J. Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance. The Journal of Biological Chemistry. 267: 26172-80. PMID 1464627 |
0.615 |
|
| 1992 |
Brown MS, Goldstein JL. Koch's postulates for cholesterol. Cell. 71: 187-8. PMID 1423585 DOI: 10.1016/0092-8674(92)90346-E |
0.436 |
|
| 1992 |
Reiss Y, Seabra MC, Brown MS, Goldstein JL. p21ras farnesyltransferase: purification and properties of the enzyme. Biochemical Society Transactions. 20: 487-8. PMID 1397646 DOI: 10.1042/BST0200487 |
0.367 |
|
| 1992 |
Seabra MC, Goldstein JL, Südhof TC, Brown MS. Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys. The Journal of Biological Chemistry. 267: 14497-503. PMID 1321151 |
0.543 |
|
| 1992 |
Kim C, Goldstein J, Brown M. cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function Journal of Biological Chemistry. 267: 23113-23121. DOI: 10.1016/s0021-9258(18)50064-8 |
0.336 |
|
| 1992 |
Yokode M, Hammer RE, Pathak RK, Ishibashi S, Anderson RG, Brown MS, Goldstein JL. Transgenic mice: A new approach to lipoprotein metabolism and atherogenesis Journal of Molecular and Cellular Cardiology. 24: 39. DOI: 10.1016/0022-2828(92)90146-Q |
0.415 |
|
| 1991 |
Yokode M, Hammer RE, Ishibashi S, Brown MS, Goldstein JL. Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors. Science (New York, N.Y.). 250: 1273-5. PMID 2244210 DOI: 10.1126/SCIENCE.2244210 |
0.523 |
|
| 1991 |
Hobbs HH, Russell DW, Brown MS, Goldstein JL. The LDL receptor locus in familial hypercholesterolemia: mutational analysis of a membrane protein. Annual Review of Genetics. 24: 133-70. PMID 2088165 DOI: 10.1146/Annurev.Ge.24.120190.001025 |
0.657 |
|
| 1991 |
Seabra MC, Reiss Y, Casey PJ, Brown MS, Goldstein JL. Protein farnesyltransferase and geranylgeranyltransferase share a common α subunit Cell. 65: 429-434. PMID 2018975 DOI: 10.1016/0092-8674(91)90460-G |
0.409 |
|
| 1991 |
Reiss Y, Stradley SJ, Gierasch LM, Brown MS, Goldstein JL. Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 88: 732-6. PMID 1992464 DOI: 10.1073/Pnas.88.3.732 |
0.425 |
|
| 1991 |
Chen WJ, Andres DA, Goldstein JL, Russell DW, Brown MS. cDNA cloning and expression of the peptide-binding beta subunit of rat p21ras farnesyltransferase, the counterpart of yeast DPR1/RAM1. Cell. 66: 327-34. PMID 1855253 DOI: 10.1016/0092-8674(91)90622-6 |
0.652 |
|
| 1991 |
Herz J, Goldstein JL, Strickland DK, Ho YK, Brown MS. 39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. The Journal of Biological Chemistry. 266: 21232-8. PMID 1718973 |
0.604 |
|
| 1991 |
Brown MS, Herz J, Kowal RC, Goldstein JL. The low-density lipoprotein receptor-related protein: double agent or decoy? Current Opinion in Lipidology. 2: 65-72. DOI: 10.1097/00041433-199104000-00002 |
0.66 |
|
| 1991 |
Mehta K, Brown M, Bilheimer D, Goldstein J. The low density lipoprotein receptor in Xenopus laevis. II. Feedback repression mediated by conserved sterol regulatory element Journal of Biological Chemistry. 266: 10415-10419. DOI: 10.1016/s0021-9258(18)99241-0 |
0.444 |
|
| 1991 |
Mehta K, Chen W, Goldstein J, Brown M. The low density lipoprotein receptor in Xenopus laevis. I. Five domains that resemble the human receptor Journal of Biological Chemistry. 266: 10406-10414. DOI: 10.1016/s0021-9258(18)99240-9 |
0.45 |
|
| 1991 |
Metherall J, Ridgway N, Dawson P, Goldstein J, Brown M. A 25-hydroxycholesterol-resistant cell line deficient in acyl-CoA: cholesterol acyltransferase Journal of Biological Chemistry. 266: 12734-12740. DOI: 10.1016/s0021-9258(18)98960-x |
0.388 |
|
| 1991 |
Goldstein J, Brown M, Stradley S, Reiss Y, Gierasch L. Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase Journal of Biological Chemistry. 266: 15575-15578. DOI: 10.1016/s0021-9258(18)98441-3 |
0.306 |
|
| 1991 |
Dawson P, Metherall J, Ridgway N, Brown M, Goldstein J. Genetic distinction between sterol-mediated transcriptional and posttranscriptional control of 3-hydroxy-3-methylglutaryl-coenzyme A reductase Journal of Biological Chemistry. 266: 9128-9134. DOI: 10.1016/s0021-9258(18)31560-6 |
0.329 |
|
| 1990 |
Kowal RC, Herz J, Weisgraber KH, Mahley RW, Brown MS, Goldstein JL. Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein. The Journal of Biological Chemistry. 265: 10771-9. PMID 2355022 |
0.637 |
|
| 1990 |
Brown MS, Goldstein JL. Atherosclerosis. Scavenging for receptors. Nature. 343: 508-9. PMID 2300201 DOI: 10.1038/343508A0 |
0.468 |
|
| 1990 |
Weisgraber KH, Mahley RW, Kowal RC, Herz J, Goldstein JL, Brown MS. Apolipoprotein C-I modulates the interaction of apolipoprotein E with beta-migrating very low density lipoproteins (beta-VLDL) and inhibits binding of beta-VLDL to low density lipoprotein receptor-related protein. The Journal of Biological Chemistry. 265: 22453-9. PMID 2266137 |
0.584 |
|
| 1990 |
Herz J, Kowal RC, Ho YK, Brown MS, Goldstein JL. Low density lipoprotein receptor-related protein mediates endocytosis of monoclonal antibodies in cultured cells and rabbit liver. The Journal of Biological Chemistry. 265: 21355-62. PMID 2250029 |
0.598 |
|
| 1990 |
Pathak RK, Yokode M, Hammer RE, Hofmann SL, Brown MS, Goldstein JL, Anderson RG. Tissue-specific sorting of the human LDL receptor in polarized epithelia of transgenic mice. The Journal of Cell Biology. 111: 347-59. PMID 2199454 DOI: 10.1083/JCB.111.2.347 |
0.527 |
|
| 1990 |
Reiss Y, Goldstein JL, Seabra MC, Casey PJ, Brown MS. Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides Cell. 62: 81-88. PMID 2194674 DOI: 10.1016/0092-8674(90)90242-7 |
0.435 |
|
| 1990 |
Brown MS, Goldstein JL. Lipoprotein receptors: therapeutic implications. Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension. 8: S33-5; discussion S3. PMID 2185351 DOI: 10.1097/00004872-199003001-00007 |
0.565 |
|
| 1990 |
Hofmann SL, Eaton DL, Brown MS, McConathy WJ, Goldstein JL, Hammer RE. Overexpression of human low density lipoprotein receptors leads to accelerated catabolism of Lp(a) lipoprotein in transgenic mice. The Journal of Clinical Investigation. 85: 1542-7. PMID 2139667 DOI: 10.1172/JCI114602 |
0.528 |
|
| 1990 |
Herz J, Kowal RC, Goldstein JL, Brown MS. Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment. The Embo Journal. 9: 1769-76. PMID 2112085 DOI: 10.1002/J.1460-2075.1990.Tb08301.X |
0.65 |
|
| 1990 |
Levanon D, Hsieh CL, Francke U, Dawson PA, Ridgway ND, Brown MS, Goldstein JL. cDNA cloning of human oxysterol-binding protein and localization of the gene to human chromosome 11 and mouse chromosome 19. Genomics. 7: 65-74. PMID 1970801 DOI: 10.1016/0888-7543(90)90519-Z |
0.464 |
|
| 1990 |
Goldstein JL, Brown MS. Regulation of the mevalonate pathway. Nature. 343: 425-30. PMID 1967820 DOI: 10.1038/343425A0 |
0.501 |
|
| 1990 |
REISS Y, SEABRA M, GOLDSTEIN J, BROWN M. Purification of ras farnesyl:Protein transferase Methods. 1: 241-245. DOI: 10.1016/S1046-2023(05)80323-8 |
0.415 |
|
| 1990 |
Smith JR, Osborne TF, Goldstein JL, Brown MS. Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene. Journal of Biological Chemistry. 265: 2306-2310. DOI: 10.1016/s0021-9258(19)39976-4 |
0.445 |
|
| 1990 |
Chen WJ, Goldstein JL, Brown MS. NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor. Journal of Biological Chemistry. 265: 3116-3123. DOI: 10.1016/s0021-9258(19)39742-x |
0.435 |
|
| 1989 |
Kowal RC, Herz J, Goldstein JL, Esser V, Brown MS. Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins. Proceedings of the National Academy of Sciences of the United States of America. 86: 5810-4. PMID 2762297 DOI: 10.1073/Pnas.86.15.5810 |
0.677 |
|
| 1989 |
Hobbs HH, Leitersdorf E, Leffert CC, Cryer DR, Brown MS, Goldstein JL. Evidence for a dominant gene that suppresses hypercholesterolemia in a family with defective low density lipoprotein receptors. The Journal of Clinical Investigation. 84: 656-64. PMID 2760205 DOI: 10.1172/JCI114212 |
0.71 |
|
| 1989 |
Hofmann SL, Brown MS, Lee E, Pathak RK, Anderson RGW, Goldstein JL. Purification of a sarcoplasmic reticulum protein that binds Ca2+ and plasma lipoproteins Journal of Biological Chemistry. 264: 8260-8270. DOI: 10.1016/s0021-9258(18)83178-7 |
0.374 |
|
| 1989 |
Dawson PA, Van der Westhuyzen DR, Goldstein JL, Brown MS. Purification of Oxysterol Binding Protein from Hamster Liver Cytosol Journal of Biological Chemistry. 264: 9046-9052. DOI: 10.1016/s0021-9258(18)81900-7 |
0.359 |
|
| 1989 |
Van Driel IR, Brown MS, Goldstein JL. Stoichiometric Binding of Low Density Lipoprotein (LDL) and Monoclonal Antibodies to Ldl Receptors in a Solid Phase Assay Journal of Biological Chemistry. 264: 9533-9538. DOI: 10.1016/s0021-9258(18)60564-2 |
0.449 |
|
| 1988 |
Hofmann SL, Russell DW, Brown MS, Goldstein JL, Hammer RE. Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice. Science (New York, N.Y.). 239: 1277-81. PMID 3344433 DOI: 10.1126/Science.3344433 |
0.535 |
|
| 1988 |
Hobbs HH, Leitersdorf E, Goldstein JL, Brown MS, Russell DW. Multiple crm- mutations in familial hypercholesterolemia. Evidence for 13 alleles, including four deletions. The Journal of Clinical Investigation. 81: 909-17. PMID 3343347 DOI: 10.1172/Jci113402 |
0.638 |
|
| 1988 |
Dawson PA, Hofmann SL, van der Westhuyzen DR, Südhof TC, Brown MS, Goldstein JL. Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1. The Journal of Biological Chemistry. 263: 3372-9. PMID 3277969 |
0.585 |
|
| 1988 |
Gil G, Smith JR, Goldstein JL, Slaughter CA, Orth K, Brown MS, Osborne TF. Multiple genes encode nuclear factor 1-like proteins that bind to the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proceedings of the National Academy of Sciences of the United States of America. 85: 8963-7. PMID 3194401 DOI: 10.1073/Pnas.85.23.8963 |
0.466 |
|
| 1988 |
Pathak RK, Merkle RK, Cummings RD, Goldstein JL, Brown MS, Anderson RG. Immunocytochemical localization of mutant low density lipoprotein receptors that fail to reach the Golgi complex. The Journal of Cell Biology. 106: 1831-41. PMID 2898477 DOI: 10.1083/jcb.106.6.1831 |
0.532 |
|
| 1988 |
Swanson LW, Simmons DM, Hofmann SL, Goldstein JL, Brown MS. Localization of mRNA for low density lipoprotein receptor and a cholesterol synthetic enzyme in rabbit nervous system by in situ hybridization. Proceedings of the National Academy of Sciences of the United States of America. 85: 9821-5. PMID 2462254 DOI: 10.1073/Pnas.85.24.9821 |
0.569 |
|
| 1988 |
Osborne TF, Gil G, Goldstein JL, Brown MS. Operator constitutive mutation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter abolishes protein binding to sterol regulatory element. Journal of Biological Chemistry. 263: 3380-3387. DOI: 10.1016/s0021-9258(18)69082-9 |
0.357 |
|
| 1988 |
Peacock SL, Bates MP, Russell DW, Brown MS, Goldstein JL. Human low density lipoprotein receptor expressed in Xenopus oocytes. Conserved signals for O-linked glycosylation and receptor-mediated endocytosis. Journal of Biological Chemistry. 263: 7838-7845. DOI: 10.1016/s0021-9258(18)68574-6 |
0.43 |
|
| 1988 |
Nakanishi M, Goldstein JL, Brown MS. Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme. Journal of Biological Chemistry. 263: 8929-8937. DOI: 10.1016/s0021-9258(18)68397-8 |
0.31 |
|
| 1988 |
Esser V, Limbird LE, Brown MS, Goldstein JL, Russell DW. Mutational analysis of the ligand binding domain of the low density lipoprotein receptor. Journal of Biological Chemistry. 263: 13282-13290. DOI: 10.1016/s0021-9258(18)37702-0 |
0.436 |
|
| 1988 |
Gil G, Osborne TF, Goldstein JL, Brown MS. Purification of a protein doublet that binds to six TGG-containing sequences in the promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Journal of Biological Chemistry. 263: 19009-19019. DOI: 10.1016/s0021-9258(18)37382-4 |
0.383 |
|
| 1987 |
Lehrman MA, Goldstein JL, Russell DW, Brown MS. Duplication of seven exons in LDL receptor gene caused by Alu-Alu recombination in a subject with familial hypercholesterolemia. Cell. 48: 827-35. PMID 3815525 DOI: 10.1016/0092-8674(87)90079-1 |
0.54 |
|
| 1987 |
Brown MS, Goldstein JL. Plasma lipoproteins: teaching old dogmas new tricks. Nature. 330: 113-4. PMID 3670399 DOI: 10.1038/330113A0 |
0.436 |
|
| 1987 |
Hobbs HH, Brown MS, Russell DW, Davignon J, Goldstein JL. Deletion in the gene for the low-density-lipoprotein receptor in a majority of French Canadians with familial hypercholesterolemia. The New England Journal of Medicine. 317: 734-7. PMID 3627182 DOI: 10.1056/Nejm198709173171204 |
0.672 |
|
| 1987 |
Goldstein JL, Brown MS. Regulation of low-density lipoprotein receptors: implications for pathogenesis and therapy of hypercholesterolemia and atherosclerosis. Circulation. 76: 504-7. PMID 3621516 DOI: 10.1161/01.CIR.76.3.504 |
0.582 |
|
| 1987 |
Südhof TC, Van der Westhuyzen DR, Goldstein JL, Brown MS, Russell DW. Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene. The Journal of Biological Chemistry. 262: 10773-9. PMID 3611089 |
0.565 |
|
| 1987 |
Jingami H, Brown MS, Goldstein JL, Anderson RG, Luskey KL. Partial deletion of membrane-bound domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase eliminates sterol-enhanced degradation and prevents formation of crystalloid endoplasmic reticulum. The Journal of Cell Biology. 104: 1693-704. PMID 3584246 DOI: 10.1083/JCB.104.6.1693 |
0.48 |
|
| 1987 |
Davis CG, Goldstein JL, Südhof TC, Anderson RG, Russell DW, Brown MS. Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region. Nature. 326: 760-5. PMID 3494949 DOI: 10.1038/326760A0 |
0.619 |
|
| 1987 |
Hofmann SL, Russell DW, Goldstein JL, Brown MS. mRNA for low density lipoprotein receptor in brain and spinal cord of immature and mature rabbits. Proceedings of the National Academy of Sciences of the United States of America. 84: 6312-6. PMID 3476946 DOI: 10.1073/Pnas.84.17.6312 |
0.502 |
|
| 1987 |
Osborne TF, Gil G, Brown MS, Kowal RC, Goldstein JL. Identification of promoter elements required for in vitro transcription of hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase gene. Proceedings of the National Academy of Sciences of the United States of America. 84: 3614-8. PMID 3473472 DOI: 10.1073/pnas.84.11.3614 |
0.46 |
|
| 1987 |
Gil G, Smith JR, Goldstein JL, Brown MS. Optional exon in the 5'-untranslated region of 3-hydroxy-3-methylglutaryl coenzyme A synthase gene: conserved sequence and splicing pattern in humans and hamsters. Proceedings of the National Academy of Sciences of the United States of America. 84: 1863-6. PMID 3470763 DOI: 10.1073/PNAS.84.7.1863 |
0.459 |
|
| 1987 |
van Driel IR, Goldstein JL, Südhof TC, Brown MS. First cysteine-rich repeat in ligand-binding domain of low density lipoprotein receptor binds Ca2+ and monoclonal antibodies, but not lipoproteins. The Journal of Biological Chemistry. 262: 17443-9. PMID 3320043 |
0.596 |
|
| 1987 |
Südhof TC, Russell DW, Brown MS, Goldstein JL. 42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter. Cell. 48: 1061-9. PMID 3030558 DOI: 10.1016/0092-8674(87)90713-6 |
0.622 |
|
| 1987 |
Goldstein JL, Brown MS, Anderson RG, Russell DW, Schneider WJ. Receptor-mediated endocytosis: concepts emerging from the LDL receptor system. Annual Review of Cell Biology. 1: 1-39. PMID 2881559 DOI: 10.1146/Annurev.Cb.01.110185.000245 |
0.477 |
|
| 1987 |
Lehrman MA, Schneider WJ, Brown MS, Davis CG, Elhammer A, Russell DW, Goldstein JL. The Lebanese allele at the low density lipoprotein receptor locus. Nonsense mutation produces truncated receptor that is retained in endoplasmic reticulum. Journal of Biological Chemistry. 262: 401-410. DOI: 10.1016/s0021-9258(19)75941-9 |
0.442 |
|
| 1987 |
Kishimoto A, Brown MS, Slaughter CA, Goldstein JL. Phosphorylation of serine 833 in cytoplasmic domain of low density lipoprotein receptor by a high molecular weight enzyme resembling casein kinase II. Journal of Biological Chemistry. 262: 1344-1351. DOI: 10.1016/s0021-9258(19)75792-5 |
0.385 |
|
| 1987 |
Lehrman M, Russell D, Goldstein J, Brown M. Alu-Alu recombination deletes splice acceptor sites and produces secreted low density lipoprotein receptor in a subject with familial hypercholesterolemia. Journal of Biological Chemistry. 262: 3354-3361. DOI: 10.1016/s0021-9258(18)61510-8 |
0.448 |
|
| 1987 |
Davis C, van Driel I, Russell D, Brown M, Goldstein J. The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosis. Journal of Biological Chemistry. 262: 4075-4082. DOI: 10.1016/s0021-9258(18)61313-4 |
0.444 |
|
| 1987 |
Kishimoto A, Goldstein JL, Brown MS. Purification of catalytic subunit of low density lipoprotein receptor kinase and identification of heat-stable activator protein. Journal of Biological Chemistry. 262: 9367-9373. DOI: 10.1016/s0021-9258(18)48089-1 |
0.422 |
|
| 1987 |
van Driel IR, Davis CG, Goldstein JL, Brown MS. Self-association of the low density lipoprotein receptor mediated by the cytoplasmic domain. Journal of Biological Chemistry. 262: 16127-16134. DOI: 10.1016/s0021-9258(18)47706-x |
0.417 |
|
| 1986 |
Brown MS, Goldstein JL. The LDL receptor and HMG-CoA reductase--two membrane molecules that regulate cholesterol homeostasis. Current Topics in Cellular Regulation. 26: 3-15. PMID 4075823 DOI: 10.1016/B978-0-12-152826-3.50008-5 |
0.553 |
|
| 1986 |
Davis CG, Lehrman MA, Russell DW, Anderson RG, Brown MS, Goldstein JL. The J.D. mutation in familial hypercholesterolemia: amino acid substitution in cytoplasmic domain impedes internalization of LDL receptors. Cell. 45: 15-24. PMID 3955657 DOI: 10.1016/0092-8674(86)90533-7 |
0.521 |
|
| 1986 |
Goldstein JL, Brown MS. The LDL receptor and the regulation of cellular cholesterol metabolism. Journal of Cell Science. Supplement. 3: 131-7. PMID 3914990 DOI: 10.1242/jcs.1985.Supplement_3.13 |
0.542 |
|
| 1986 |
Brown MS, Goldstein JL. The receptor model for transport of cholesterol in plasma. Annals of the New York Academy of Sciences. 454: 178-82. PMID 3907461 DOI: 10.1111/j.1749-6632.1985.tb11856.x |
0.505 |
|
| 1986 |
Brown MS, Goldstein JL. A receptor-mediated pathway for cholesterol homeostasis. Science (New York, N.Y.). 232: 34-47. PMID 3513311 DOI: 10.1126/SCIENCE.3513311 |
0.54 |
|
| 1986 |
Russell DW, Lehrman MA, Südhof TC, Yamamoto T, Davis CG, Hobbs HH, Brown MS, Goldstein JL. The LDL receptor in familial hypercholesterolemia: use of human mutations to dissect a membrane protein. Cold Spring Harbor Symposia On Quantitative Biology. 51: 811-9. PMID 3472763 DOI: 10.1101/Sqb.1986.051.01.094 |
0.727 |
|
| 1986 |
Ma PT, Gil G, Südhof TC, Bilheimer DW, Goldstein JL, Brown MS. Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits. Proceedings of the National Academy of Sciences of the United States of America. 83: 8370-4. PMID 3464957 DOI: 10.1073/Pnas.83.21.8370 |
0.656 |
|
| 1986 |
Lehrman MA, Russell DW, Goldstein JL, Brown MS. Exon-Alu recombination deletes 5 kilobases from the low density lipoprotein receptor gene, producing a null phenotype in familial hypercholesterolemia. Proceedings of the National Academy of Sciences of the United States of America. 83: 3679-83. PMID 3012527 DOI: 10.1073/Pnas.83.11.3679 |
0.509 |
|
| 1986 |
Yamamoto T, Bishop RW, Brown MS, Goldstein JL, Russell DW. Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit. Science (New York, N.Y.). 232: 1230-7. PMID 3010466 DOI: 10.1126/Science.3010466 |
0.552 |
|
| 1986 |
Ma PT, Yamamoto T, Goldstein JL, Brown MS. Increased mRNA for low density lipoprotein receptor in livers of rabbits treated with 17 alpha-ethinyl estradiol. Proceedings of the National Academy of Sciences of the United States of America. 83: 792-6. PMID 2418443 DOI: 10.1073/PNAS.83.3.792 |
0.533 |
|
| 1986 |
Hobbs HH, Brown MS, Goldstein JL, Russell DW. Deletion of exon encoding cysteine-rich repeat of low density lipoprotein receptor alters its binding specificity in a subject with familial hypercholesterolemia. Journal of Biological Chemistry. 261: 13114-13120. DOI: 10.1016/s0021-9258(18)69278-6 |
0.471 |
|
| 1986 |
BROWN MS, GOLDSTEIN JL. ChemInform Abstract: A Receptor-Mediated Pathway for Cholesterol Homeostasis (Nobel Lecture) Chemischer Informationsdienst. 17. DOI: 10.1002/CHIN.198645362 |
0.47 |
|
| 1986 |
Brown MS, Goldstein JL. A Receptor-Mediated Pathway for Cholesterol Homeostasis(Nobel Lecture) Angewandte Chemie International Edition in English. 25: 583-602. DOI: 10.1002/ANIE.198605833 |
0.54 |
|
| 1986 |
Brown MS, Goldstein JL. Ein Rezeptor-vermittelter Stoffwechselweg für die Cholesterin-Homöostase (Nobel-Vortrag) Angewandte Chemie. 98: 579-599. DOI: 10.1002/ANGE.19860980702 |
0.338 |
|
| 1985 |
Huettinger M, Corbett JR, Schneider WJ, Willerson JT, Brown MS, Goldstein JL. Imaging of hepatic low density lipoprotein receptors by radionuclide scintiscanning in vivo. Proceedings of the National Academy of Sciences of the United States of America. 81: 7599-603. PMID 6594702 DOI: 10.1073/PNAS.81.23.7599 |
0.537 |
|
| 1985 |
Brown MS, Goldstein JL. How LDL receptors influence cholesterol and atherosclerosis. Scientific American. 251: 58-66. PMID 6390676 DOI: 10.1038/SCIENTIFICAMERICAN1184-58 |
0.558 |
|
| 1985 |
Bilheimer DW, Goldstein JL, Grundy SM, Starzl TE, Brown MS. Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia. The New England Journal of Medicine. 311: 1658-64. PMID 6390206 DOI: 10.1056/Nejm198412273112603 |
0.571 |
|
| 1985 |
Brown MS, Goldstein JL. Scavenger cell receptor shared. Nature. 316: 680-1. PMID 4033768 DOI: 10.1038/316680A0 |
0.465 |
|
| 1985 |
Gil G, Faust JR, Chin DJ, Goldstein JL, Brown MS. Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme. Cell. 41: 249-58. PMID 3995584 DOI: 10.1016/0092-8674(85)90078-9 |
0.504 |
|
| 1985 |
Schneider WJ, Goldstein JL, Brown MS. Purification of the LDL receptor. Methods in Enzymology. 109: 405-17. PMID 3990570 DOI: 10.1016/0076-6879(85)09106-6 |
0.577 |
|
| 1985 |
Goldstein JL, Brown MS. Familial hypercholesterolemia: a genetic receptor disease. Hospital Practice (Office Ed.). 20: 35-41, 45-6. PMID 3932389 DOI: 10.1080/21548331.1985.11703185 |
0.411 |
|
| 1985 |
Lehrman MA, Goldstein JL, Brown MS, Russell DW, Schneider WJ. Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain. Cell. 41: 735-43. PMID 3924410 DOI: 10.1016/S0092-8674(85)80054-4 |
0.536 |
|
| 1985 |
Südhof TC, Russell DW, Goldstein JL, Brown MS, Sanchez-Pescador R, Bell GI. Cassette of eight exons shared by genes for LDL receptor and EGF precursor. Science (New York, N.Y.). 228: 893-5. PMID 3873704 DOI: 10.1126/Science.3873704 |
0.626 |
|
| 1985 |
Osborne TF, Goldstein JL, Brown MS. 5' end of HMG CoA reductase gene contains sequences responsible for cholesterol-mediated inhibition of transcription. Cell. 42: 203-12. PMID 3860301 DOI: 10.1016/S0092-8674(85)80116-1 |
0.472 |
|
| 1985 |
Chin DJ, Gil G, Faust JR, Goldstein JL, Brown MS, Luskey KL. Sterols accelerate degradation of hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase encoded by a constitutively expressed cDNA. Molecular and Cellular Biology. 5: 634-41. PMID 3838796 DOI: 10.1128/MCB.5.4.634 |
0.547 |
|
| 1985 |
Lehrman MA, Schneider WJ, Südhof TC, Brown MS, Goldstein JL, Russell DW. Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains. Science (New York, N.Y.). 227: 140-6. PMID 3155573 DOI: 10.1126/Science.3155573 |
0.649 |
|
| 1985 |
Südhof TC, Goldstein JL, Brown MS, Russell DW. The LDL receptor gene: a mosaic of exons shared with different proteins. Science (New York, N.Y.). 228: 815-22. PMID 2988123 DOI: 10.1126/Science.2988123 |
0.604 |
|
| 1985 |
Liscum L, Finer-Moore J, Stroud RM, Luskey KL, Brown MS, Goldstein JL. Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum. Journal of Biological Chemistry. 260: 522-530. DOI: 10.1016/s0021-9258(18)89764-2 |
0.307 |
|
| 1985 |
Reynolds GA, Goldstein JL, Brown MS. Multiple mRNAs for 3-hydroxy-3-methylglutaryl coenzyme A reductase determined by multiple transcription initiation sites and intron splicing sites in the 5'-untranslated region. Journal of Biological Chemistry. 260: 10369-10377. DOI: 10.1016/s0021-9258(17)39257-8 |
0.3 |
|
| 1984 |
Orci L, Brown MS, Goldstein JL, Garcia-Segura LM, Anderson RG. Increase in membrane cholesterol: a possible trigger for degradation of HMG CoA reductase and crystalloid endoplasmic reticulum in UT-1 cells. Cell. 36: 835-45. PMID 6705048 DOI: 10.1016/0092-8674(84)90033-3 |
0.553 |
|
| 1984 |
Chin DJ, Gil G, Russell DW, Liscum L, Luskey KL, Basu SK, Okayama H, Berg P, Goldstein JL, Brown MS. Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum Nature. 308: 613-617. PMID 6546784 DOI: 10.1038/308613A0 |
0.467 |
|
| 1984 |
Russell DW, Schneider WJ, Yamamoto T, Luskey KL, Brown MS, Goldstein JL. Domain map of the LDL receptor: sequence homology with the epidermal growth factor precursor. Cell. 37: 577-85. PMID 6327078 DOI: 10.1016/0092-8674(84)90388-X |
0.5 |
|
| 1984 |
Francke U, Brown MS, Goldstein JL. Assignment of the human gene for the low density lipoprotein receptor to chromosome 19: synteny of a receptor, a ligand, and a genetic disease. Proceedings of the National Academy of Sciences of the United States of America. 81: 2826-30. PMID 6326146 DOI: 10.1073/Pnas.81.9.2826 |
0.512 |
|
| 1984 |
Goldstein JL, Basu SK, Brown MS. Receptor-mediated endocytosis of low-density lipoprotein in cultured cells. Methods in Enzymology. 98: 241-60. PMID 6321901 DOI: 10.1016/0076-6879(83)98152-1 |
0.572 |
|
| 1984 |
Larkin JM, Brown MS, Goldstein JL, Anderson RG. Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts. Cell. 33: 273-85. PMID 6147196 DOI: 10.1016/0092-8674(83)90356-2 |
0.442 |
|
| 1984 |
Anderson RG, Falck JR, Goldstein JL, Brown MS. Visualization of acidic organelles in intact cells by electron microscopy. Proceedings of the National Academy of Sciences of the United States of America. 81: 4838-42. PMID 6146980 DOI: 10.1073/Pnas.81.15.4838 |
0.408 |
|
| 1984 |
Russell DW, Yamamoto T, Schneider WJ, Slaughter CJ, Brown MS, Goldstein JL. cDNA cloning of the bovine low density lipoprotein receptor: feedback regulation of a receptor mRNA. Proceedings of the National Academy of Sciences of the United States of America. 80: 7501-5. PMID 6143315 DOI: 10.1073/Pnas.80.24.7501 |
0.537 |
|
| 1984 |
Yamamoto T, Davis CG, Brown MS, Schneider WJ, Casey ML, Goldstein JL, Russell DW. The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell. 39: 27-38. PMID 6091915 DOI: 10.1016/0092-8674(84)90188-0 |
0.545 |
|
| 1984 |
Huettinger M, Schneider WJ, Ho YK, Goldstein JL, Brown MS. Use of monoclonal anti-receptor antibodies to probe the expression of the low density lipoprotein receptor in tissues of normal and Watanabe heritable hyperlipidemic rabbits. The Journal of Clinical Investigation. 74: 1017-26. PMID 6088578 DOI: 10.1172/JCI111469 |
0.521 |
|
| 1984 |
Reynolds GA, Basu SK, Osborne TF, Chin DJ, Gil G, Brown MS, Goldstein JL, Luskey KL. HMG CoA reductase: a negatively regulated gene with unusual promoter and 5' untranslated regions. Cell. 38: 275-85. PMID 6088070 DOI: 10.1016/0092-8674(84)90549-X |
0.457 |
|
| 1983 |
Chin DJ, Luskey KL, Faust JR, MacDonald RJ, Brown MS, Goldstein JL. Molecular cloning of 3-hydroxy-3-methylglutaryl coenzyme a reductase and evidence for regulation of its mRNA. Proceedings of the National Academy of Sciences of the United States of America. 79: 7704-8. PMID 6961444 DOI: 10.1073/PNAS.79.24.7704 |
0.466 |
|
| 1983 |
Buja LM, Kita T, Goldstein JL, Watanabe Y, Brown MS. Cellular pathology of progressive atherosclerosis in the WHHL rabbit. An animal model of familial hypercholesterolemia. Arteriosclerosis (Dallas, Tex.). 3: 87-101. PMID 6824499 DOI: 10.1161/01.ATV.3.1.87 |
0.501 |
|
| 1983 |
Basu SK, Goldstein JL, Brown MS. Independent pathways for secretion of cholesterol and apolipoprotein E by macrophages. Science (New York, N.Y.). 219: 871-3. PMID 6823554 DOI: 10.1126/SCIENCE.6823554 |
0.541 |
|
| 1983 |
Schneider WJ, Slaughter CJ, Goldstein JL, Anderson RG, Capra JD, Brown MS. Use of antipeptide antibodies to demonstrate external orientation of the NH2-terminus of the low density lipoprotein receptor in the plasma membrane of fibroblasts. The Journal of Cell Biology. 97: 1635-40. PMID 6313699 DOI: 10.1083/JCB.97.5.1635 |
0.542 |
|
| 1983 |
Brown MS, Goldstein JL. Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Annual Review of Biochemistry. 52: 223-61. PMID 6311077 DOI: 10.1146/ANNUREV.BI.52.070183.001255 |
0.49 |
|
| 1983 |
Brown MS, Goldstein JL. Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic. The Journal of Clinical Investigation. 72: 743-7. PMID 6309907 DOI: 10.1172/JCI111044 |
0.571 |
|
| 1983 |
Goldstein JL, Kita T, Brown MS. Defective lipoprotein receptors and atherosclerosis. Lessons from an animal counterpart of familial hypercholesterolemia. The New England Journal of Medicine. 309: 288-96. PMID 6306464 DOI: 10.1056/NEJM198308043090507 |
0.537 |
|
| 1983 |
Daniel TO, Schneider WJ, Goldstein JL, Brown MS. Visualization of lipoprotein receptors by ligand blotting. The Journal of Biological Chemistry. 258: 4606-11. PMID 6300091 |
0.678 |
|
| 1983 |
Tolleshaug H, Hobgood KK, Brown MS, Goldstein JL. The LDL receptor locus in familial hypercholesterolemia: multiple mutations disrupt transport and processing of a membrane receptor. Cell. 32: 941-51. PMID 6299582 DOI: 10.1016/0092-8674(83)90079-X |
0.511 |
|
| 1983 |
Brown MS, Anderson RG, Goldstein JL. Recycling receptors: the round-trip itinerary of migrant membrane proteins. Cell. 32: 663-7. PMID 6299572 DOI: 10.1016/0092-8674(83)90052-1 |
0.47 |
|
| 1983 |
Tolleshaug H, Goldstein JL, Schneider WJ, Brown MS. Posttranslational processing of the LDL receptor and its genetic disruption in familial hypercholesterolemia. Cell. 30: 715-24. PMID 6291781 DOI: 10.1016/0092-8674(82)90276-8 |
0.526 |
|
| 1983 |
Goldstein JL, Anderson RG, Brown MS. Receptor-mediated endocytosis and the cellular uptake of low density lipoprotein. Ciba Foundation Symposium. 77-95. PMID 6129958 DOI: 10.1002/9780470720745.CH5 |
0.51 |
|
| 1983 |
Mosley ST, Brown MS, Anderson RG, Goldstein JL. Mutant clone of Chinese hamster ovary cells lacking 3-hydroxy-3 -methylglutaryl coenzyme A reductase. Journal of Biological Chemistry. 258: 13875-13881. DOI: 10.1016/s0021-9258(17)43999-8 |
0.354 |
|
| 1983 |
Cummings RD, Kornfeld S, Schneider WJ, Hobgood KK, Tolleshaug H, Brown MS, Goldstein JL. Biosynthesis of N- and O-linked oligosaccharides of the low density lipoprotein receptor. Journal of Biological Chemistry. 258: 15261-15273. DOI: 10.1016/s0021-9258(17)43802-6 |
0.411 |
|
| 1982 |
Havel RJ, Kita T, Kotite L, Kane JP, Hamilton RL, Goldstein JL, Brown MS. Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia. Arteriosclerosis (Dallas, Tex.). 2: 467-74. PMID 6960858 DOI: 10.1161/01.ATV.2.6.467 |
0.557 |
|
| 1982 |
Luskey KL, Chin DJ, MacDonald RJ, Liscum L, Goldstein JL, Brown MS. Identification of a cholesterol-regulated 53,000-dalton cytosolic protein in UT-1 cells and cloning of its cDNA Proceedings of the National Academy of Sciences of the United States of America. 79: 6210-6214. PMID 6959111 DOI: 10.1073/Pnas.79.20.6210 |
0.503 |
|
| 1982 |
Kita T, Brown MS, Bilheimer DW, Goldstein JL. Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits. Proceedings of the National Academy of Sciences of the United States of America. 79: 5693-7. PMID 6957885 DOI: 10.1073/PNAS.79.18.5693 |
0.568 |
|
| 1982 |
Faust JR, Luskey KL, Chin DJ, Goldstein JL, Brown MS. Regulation of synthesis and degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by low density lipoprotein and 25-hydroxycholesterol in UT-1 cells. Proceedings of the National Academy of Sciences of the United States of America. 79: 5205-9. PMID 6957860 DOI: 10.1073/PNAS.79.17.5205 |
0.514 |
|
| 1982 |
Chin DJ, Luskey KL, Anderson RG, Faust JR, Goldstein JL, Brown MS. Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proceedings of the National Academy of Sciences of the United States of America. 79: 1185-9. PMID 6951166 DOI: 10.1073/PNAS.79.4.1185 |
0.492 |
|
| 1982 |
Basu SK, Brown MS, Ho YK, Havel RJ, Goldstein JL. Mouse macrophages synthesize and secrete a protein resembling apolipoprotein E. Proceedings of the National Academy of Sciences of the United States of America. 78: 7545-9. PMID 6950395 DOI: 10.1073/PNAS.78.12.7545 |
0.545 |
|
| 1982 |
Anderson RG, Brown MS, Beisiegel U, Goldstein JL. Surface distribution and recycling of the low density lipoprotein receptor as visualized with antireceptor antibodies. The Journal of Cell Biology. 93: 523-31. PMID 6288727 DOI: 10.1083/JCB.93.3.523 |
0.472 |
|
| 1982 |
Brown MS, Anderson RG, Basu SK, Goldstein JL. Recycling of cell-surface receptors: observations from the LDL receptor system. Cold Spring Harbor Symposia On Quantitative Biology. 713-21. PMID 6286220 DOI: 10.1101/SQB.1982.046.01.068 |
0.493 |
|
| 1982 |
Kita T, Goldstein JL, Brown MS, Watanabe Y, Hornick CA, Havel RJ. Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor. Proceedings of the National Academy of Sciences of the United States of America. 79: 3623-7. PMID 6285353 DOI: 10.1073/PNAS.79.11.3623 |
0.557 |
|
| 1982 |
Goldstein JL, Brown MS. The LDL receptor defect in familial hypercholesterolemia. Implications for pathogenesis and therapy. The Medical Clinics of North America. 66: 335-62. PMID 6279983 DOI: 10.1016/S0025-7125(16)31424-9 |
0.507 |
|
| 1982 |
Anderson RG, Goldstein JL, Brown MS. Fluorescence visualization of receptor-bound low density lipoprotein in human fibroblasts. Journal of Receptor Research. 1: 17-39. PMID 6271950 DOI: 10.3109/10799898009039253 |
0.443 |
|
| 1982 |
Carpentier JL, Gorden P, Anderson RG, Goldstein JL, Brown MS, Cohen S, Orci L. Co-localization of 125I-epidermal growth factor and ferritin-low density lipoprotein in coated pits: a quantitative electron microscopic study in normal and mutant human fibroblasts. The Journal of Cell Biology. 95: 73-7. PMID 6128346 DOI: 10.1083/Jcb.95.1.73 |
0.507 |
|
| 1982 |
Schneider WJ, Beisiegel U, Goldstein JL, Brown MS. Purification of the low density lipoprotein receptor, an acidic glycoprotein of 164,000 molecular weight. Journal of Biological Chemistry. 257: 2664-2673. DOI: 10.1016/s0021-9258(18)34975-5 |
0.419 |
|
| 1982 |
Beisiegel U, Schneider WJ, Brown MS, Goldstein JL. Immunoblot analysis of low density lipoprotein receptors in fibroblasts from subjects with familial hypercholesterolemia. Journal of Biological Chemistry. 257: 13150-13156. DOI: 10.1016/s0021-9258(18)33635-4 |
0.44 |
|
| 1981 |
Goldstein JL, Hoff HF, Ho YK, Basu SK, Brown MS. Stimulation of cholesteryl ester synthesis in macrophages by extracts of atherosclerotic human aortas and complexes of albumin/cholesteryl esters. Arteriosclerosis (Dallas, Tex.). 1: 210-26. PMID 7295194 DOI: 10.1161/01.ATV.1.3.210 |
0.483 |
|
| 1981 |
Kita T, Brown MS, Goldstein JL. Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase. The Journal of Clinical Investigation. 66: 1094-100. PMID 6903572 DOI: 10.1172/JCI109938 |
0.502 |
|
| 1981 |
Krieger M, Brown MS, Goldstein JL. Isolation of Chinese hamster cell mutants defective in the receptor-mediated endocytosis of low density lipoprotein. Journal of Molecular Biology. 150: 167-84. PMID 6275086 DOI: 10.1016/0022-2836(81)90447-2 |
0.679 |
|
| 1981 |
Mosley ST, Goldstein JL, Brown MS, Falck JR, Anderson RG. Targeted killing of cultured cells by receptor-dependent photosensitization Proceedings of the National Academy of Sciences of the United States of America. 78: 5717-5721. PMID 6272315 DOI: 10.1073/Pnas.78.9.5717 |
0.529 |
|
| 1981 |
Schneider WJ, Kovanen PT, Brown MS, Goldstein JL, Utermann G, Weber W, Havel RJ, Kotite L, Kane JP, Innerarity TL, Mahley RW. Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows. The Journal of Clinical Investigation. 68: 1075-85. PMID 6270194 DOI: 10.1172/JCI110330 |
0.512 |
|
| 1981 |
Brown MS, Goldstein JL. Lowering plasma cholesterol by raising LDL receptors. The New England Journal of Medicine. 305: 515-7. PMID 6265781 DOI: 10.1056/NEJM198108273050909 |
0.545 |
|
| 1981 |
Kita T, Brown MS, Watanabe Y, Goldstein JL. Deficiency of low density lipoprotein receptors in liver and adrenal gland of the WHHL rabbit, an animal model of familial hypercholesterolemia. Proceedings of the National Academy of Sciences of the United States of America. 78: 2268-72. PMID 6264472 DOI: 10.1073/PNAS.78.4.2268 |
0.582 |
|
| 1981 |
Basu SK, Goldstein JL, Anderson RG, Brown MS. Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts. Cell. 24: 493-502. PMID 6263497 DOI: 10.1016/0092-8674(81)90340-8 |
0.525 |
|
| 1981 |
Kovanen PT, Brown MS, Basu SK, Bilheimer DW, Goldstein JL. Saturation and suppression of hepatic lipoprotein receptors: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits. Proceedings of the National Academy of Sciences of the United States of America. 78: 1396-400. PMID 6262794 DOI: 10.1073/PNAS.78.3.1396 |
0.56 |
|
| 1981 |
Kovanen PT, Bilheimer DW, Goldstein JL, Jaramillo JJ, Brown MS. Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog. Proceedings of the National Academy of Sciences of the United States of America. 78: 1194-8. PMID 6262757 DOI: 10.1073/PNAS.78.2.1194 |
0.591 |
|
| 1981 |
Brown MS, Kovanen PT, Goldstein JL. Regulation of plasma cholesterol by lipoprotein receptors. Science (New York, N.Y.). 212: 628-35. PMID 6261329 DOI: 10.1126/SCIENCE.6261329 |
0.573 |
|
| 1981 |
Anderson RG, Brown MS, Goldstein JL. Inefficient internalization of receptor-bound low density lipoprotein in human carcinoma A-431 cells. The Journal of Cell Biology. 88: 441-52. PMID 6259181 DOI: 10.1083/JCB.88.2.441 |
0.549 |
|
| 1981 |
Brown MS, Basu SK, Falck JR, Ho YK, Goldstein JL. The scavenger cell pathway for lipoprotein degradation: specificity of the binding site that mediates the uptake of negatively-charged LDL by macrophages. Journal of Supramolecular Structure. 13: 67-81. PMID 6255257 DOI: 10.1002/JSS.400130107 |
0.522 |
|
| 1981 |
Beisiegel U, Kita T, Anderson R, Schneider W, Brown M, Goldstein J. Immunologic cross-reactivity of the low density lipoprotein receptor from bovine adrenal cortex, human fibroblasts, canine liver and adrenal gland, and rat liver. Journal of Biological Chemistry. 256: 4071-4078. DOI: 10.1016/s0021-9258(19)69566-9 |
0.393 |
|
| 1981 |
Kita T, Beisiegel U, Goldstein J, Schneider W, Brown M. Antibody against low density lipoprotein receptor blocks uptake of low density lipoprotein (but not high density lipoprotein) by the adrenal gland of the mouse in vivo. Journal of Biological Chemistry. 256: 4701-4703. DOI: 10.1016/s0021-9258(19)69305-1 |
0.454 |
|
| 1981 |
Beisiegel U, Schneider W, Goldstein J, Anderson R, Brown M. Monoclonal antibodies to the low density lipoprotein receptor as probes for study of receptor-mediated endocytosis and the genetics of familial hypercholesterolemia. Journal of Biological Chemistry. 256: 11923-11931. DOI: 10.1016/s0021-9258(19)68494-2 |
0.428 |
|
| 1981 |
Falck JR, Krieger M, Goldstein JL, Brown MS. Preparation and spectral properties of lipophilic fluorescein derivatives: application to plasma low-density lipoprotein Journal of the American Chemical Society. 103: 7396-7398. DOI: 10.1002/Chin.198213304 |
0.61 |
|
| 1980 |
Chen GC, Krieger M, Kane JP, Wu CS, Brown MS, Goldstein JL. beta-Carotene as a probe of lipid domains of reconstituted human plasma low-density lipoprotein: induced circular dichroism. Biochemistry. 19: 4706-12. PMID 7426623 DOI: 10.1021/Bi00561A025 |
0.621 |
|
| 1980 |
Brown MS, Kovanen PT, Goldstein JL. Evolution of the LDL receptor concept-from cultured cells to intact animals. Annals of the New York Academy of Sciences. 348: 48-68. PMID 6994567 DOI: 10.1111/j.1749-6632.1980.tb21290.x |
0.566 |
|
| 1980 |
Mello RJ, Brown MS, Goldstein JL, Anderson RG. LDL receptors in coated vesicles isolated from bovine adrenal cortex: binding sites unmasked by detergent treatment. Cell. 20: 829-37. PMID 6251975 DOI: 10.1016/0092-8674(80)90329-3 |
0.498 |
|
| 1980 |
Krieger M, Peterson J, Goldstein JL, Brown MS. Mobility of apolar lipids of reconstituted low density lipoprotein as monitored by electron spin resonance spectroscopy. The Journal of Biological Chemistry. 255: 3330-3. PMID 6245076 |
0.554 |
|
| 1980 |
Goldstein JL, Brown MS. The LDL receptor locus and the genetics of familial hypercholesterolemia. Annual Review of Genetics. 13: 259-89. PMID 231932 DOI: 10.1146/ANNUREV.GE.13.120179.001355 |
0.475 |
|
| 1980 |
Schneider WJ, Basu SK, McPhaul MJ, Goldstein JL, Brown MS. Solubilization of the low density lipoprotein receptor. Proceedings of the National Academy of Sciences of the United States of America. 76: 5577-81. PMID 230482 DOI: 10.1073/PNAS.76.11.5577 |
0.588 |
|
| 1980 |
Brown MS, Kovanen PT, Goldstein JL. Receptor-mediated uptake of lipoprotein-cholesterol and its utilization for steroid synthesis in the adrenal cortex. Recent Progress in Hormone Research. 35: 215-57. PMID 229524 DOI: 10.1016/B978-0-12-571135-7.50009-6 |
0.575 |
|
| 1980 |
Faust JR, Goldstein JL, Brown MS. Squalene synthetase activity in human fibroblasts: regulation via the low density lipoprotein receptor. Proceedings of the National Academy of Sciences of the United States of America. 76: 5018-22. PMID 228272 DOI: 10.1073/PNAS.76.10.5018 |
0.577 |
|
| 1980 |
Kovanen P, Goldstein J, Chappell D, Brown M. Regulation of low density lipoprotein receptors by adrenocorticotropin in the adrenal gland of mice and rats in vivo. Journal of Biological Chemistry. 255: 5591-5598. DOI: 10.1016/s0021-9258(19)70671-1 |
0.435 |
|
| 1980 |
Brown M, Ho Y, Goldstein J. The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters. Journal of Biological Chemistry. 255: 9344-9352. DOI: 10.1016/s0021-9258(19)70568-7 |
0.342 |
|
| 1980 |
Windler E, Kovanen P, Chao Y, Brown M, Havel R, Goldstein J. The estradiol-stimulated lipoprotein receptor of rat liver. A binding site that membrane mediates the uptake of rat lipoproteins containing apoproteins B and E. Journal of Biological Chemistry. 255: 10464-10471. DOI: 10.1016/s0021-9258(19)70487-6 |
0.411 |
|
| 1980 |
Schneider W, Goldstein J, Brown M. Partial purification and characterization of the low density lipoprotein receptor from bovine adrenal cortex. Journal of Biological Chemistry. 255: 11442-11447. DOI: 10.1016/s0021-9258(19)70311-1 |
0.441 |
|
| 1980 |
Faust J, Brown M, Goldstein J. Synthesis of delta 2-isopentenyl tRNA from mevalonate in cultured human fibroblasts. Journal of Biological Chemistry. 255: 6546-6548. DOI: 10.1016/s0021-9258(18)43600-9 |
0.301 |
|
| 1979 |
Krieger M, Smith LC, Anderson RG, Goldstein JL, Kao YJ, Pownall HJ, Gotto AM, Brown MS. Reconstituted low density lipoprotein: a vehicle for the delivery of hydrophobic fluorescent probes to cells. Journal of Supramolecular Structure. 10: 467-78. PMID 229357 DOI: 10.1002/Jss.400100409 |
0.632 |
|
| 1979 |
Brown MS, Goldstein JL, Krieger M, Ho YK, Anderson RG. Reversible accumulation of cholesteryl esters in macrophages incubated with acetylated lipoproteins. The Journal of Cell Biology. 82: 597-613. PMID 229107 DOI: 10.1083/Jcb.82.3.597 |
0.665 |
|
| 1979 |
Brown MS, Goldstein JL. Receptor-mediated endocytosis: insights from the lipoprotein receptor system. Proceedings of the National Academy of Sciences of the United States of America. 76: 3330-7. PMID 226968 DOI: 10.1073/PNAS.76.7.3330 |
0.579 |
|
| 1979 |
Goldstein JL, Brown MS, Krieger M, Anderson RG, Mintz B. Demonstration of low density lipoprotein receptors in mouse teratocarcinoma stem cells and description of a method for producing receptor-deficient mutant mice. Proceedings of the National Academy of Sciences of the United States of America. 76: 2843-7. PMID 223161 DOI: 10.1073/Pnas.76.6.2843 |
0.682 |
|
| 1979 |
Goldstein JL, Anderson RG, Brown MS. Coated pits, coated vesicles, and receptor-mediated endocytosis. Nature. 279: 679-85. PMID 221835 DOI: 10.1038/279679A0 |
0.467 |
|
| 1979 |
Carpentier JL, Gorden P, Goldstein JL, Anderson RG, Brown MS, Orci L. Binding and internalization of 125I-LDL in normal and mutant human fibroblasts. A quantitative autoradiographic study. Experimental Cell Research. 121: 135-42. PMID 221225 DOI: 10.1016/0014-4827(79)90453-1 |
0.509 |
|
| 1979 |
Krieger M, McPhaul MJ, Goldstein JL, Brown MS. Replacement of neutral lipids of low density lipoprotein with esters of long chain unsaturated fatty acids. The Journal of Biological Chemistry. 254: 3845-53. PMID 220222 |
0.585 |
|
| 1979 |
Kovanen PT, Basu SK, Goldstein JL, Brown MS. Low density lipoprotein receptors in bovine adrenal cortex. II. Low density lipoprotein binding to membranes prepared from fresh tissue. Endocrinology. 104: 610-6. PMID 220015 DOI: 10.1210/ENDO-104-3-610 |
0.559 |
|
| 1979 |
Kovanen PT, Faust JR, Brown MS, Goldstein JL. Low density lipoprotein receptors in bovine adrenal cortex. I. Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured adrenocortical cells. Endocrinology. 104: 599-609. PMID 220014 DOI: 10.1210/ENDO-104-3-599 |
0.6 |
|
| 1979 |
Faust JR, Goldstein JL, Brown MS. Synthesis of ubiquinone and cholesterol in human fibroblasts: regulation of a branched pathway. Archives of Biochemistry and Biophysics. 192: 86-99. PMID 219777 DOI: 10.1016/0003-9861(79)90074-2 |
0.543 |
|
| 1979 |
Goldstein JL, Ho YK, Basu SK, Brown MS. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proceedings of the National Academy of Sciences of the United States of America. 76: 333-7. PMID 218198 DOI: 10.1073/PNAS.76.1.333 |
0.563 |
|
| 1979 |
Anderson RG, Vasile E, Mello RJ, Brown MS, Goldstein JL. Immunocytochemical visualization of coated pits and vesicles in human fibroblasts: relation to low density lipoprotein receptor distribution. Cell. 15: 919-33. PMID 215316 DOI: 10.1016/0092-8674(78)90276-3 |
0.448 |
|
| 1979 |
Brown MS, Deuel TF, Basu SK, Goldstein JL. Inhibition of the binding of low-density lipoprotein to its cell surface receptor in human fibroblasts by positively charged proteins. Journal of Supramolecular Structure. 8: 223-34. PMID 214639 DOI: 10.1002/JSS.400080302 |
0.531 |
|
| 1979 |
Kovanen PT, Schneider WJ, Hillman GM, Goldstein JL, Brown MS. Separate mechanisms for the uptake of high and low density lipoproteins by mouse adrenal gland in vivo. Journal of Biological Chemistry. 254: 5498-5505. DOI: 10.1016/s0021-9258(18)50623-2 |
0.419 |
|
| 1979 |
Goldstein JL, Helgeson JA, Brown MS. Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low density lipoprotein receptor. Journal of Biological Chemistry. 254: 5403-5409. DOI: 10.1016/s0021-9258(18)50610-4 |
0.474 |
|
| 1979 |
Brown MS, Goldstein JL, Dietschy JM. Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. Comparison with the rate of cholesterol synthesis in different physiological states. Journal of Biological Chemistry. 254: 5144-5149. DOI: 10.1016/s0021-9258(18)50571-8 |
0.377 |
|
| 1979 |
Basu SK, Brown MS, Ho YK, Goldstein JL. Degradation of low density lipoprotein . dextran sulfate complexes associated with deposition of cholesteryl esters in mouse macrophages. Journal of Biological Chemistry. 254: 7141-7146. DOI: 10.1016/s0021-9258(18)50296-9 |
0.393 |
|
| 1978 |
Krieger M, Goldstein JL, Brown MS. Receptor-mediated uptake of low density lipoprotein reconstituted with 25-hydroxycholesteryl oleate suppresses 3-hydroxy-3-methylglutaryl-coenzyme A reductase and inhibits growth of human fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 75: 5052-6. PMID 217011 DOI: 10.1073/Pnas.75.10.5052 |
0.671 |
|
| 1978 |
Brown MS, Goldstein JL. Regulation of the activity of the low density lipoprotein receptor in human fibroblasts. Cell. 6: 307-16. PMID 212203 DOI: 10.1016/0092-8674(75)90182-8 |
0.599 |
|
| 1978 |
Krieger M, Brown MS, Faust JR, Goldstein JL. Replacement of endogenous cholesteryl esters of low density lipoprotein with exogenous cholesteryl linoleate. Reconstitution of a biologically active lipoprotein particle. The Journal of Biological Chemistry. 253: 4093-101. PMID 207690 |
0.595 |
|
| 1978 |
Goldstein JL, Faust JR, Dygos JH, Chorvat RJ, Brown MS. Inhibition of cholesteryl ester formation in human fibroblasts by an analogue of 7-ketocholesterol and by progesterone. Proceedings of the National Academy of Sciences of the United States of America. 75: 1877-81. PMID 205874 DOI: 10.1073/PNAS.75.4.1877 |
0.522 |
|
| 1978 |
Bilheimer DW, Ho YK, Brown MS, Anderson RG, Goldstein JL. Genetics of the low density lipoprotein receptor. Diminished receptor activity in lymphocytes from heterozygotes with familial hypercholesterolemia. The Journal of Clinical Investigation. 61: 678-96. PMID 205553 DOI: 10.1172/JCI108980 |
0.552 |
|
| 1978 |
Orci L, Carpentier JL, Perrelet A, Anderson RG, Goldstein JL, Brown MS. Occurrence of low density lipoprotein receptors within large pits on the surface of human fibroblasts as demonstrated by freeze-etching. Experimental Cell Research. 113: 1-13. PMID 205424 DOI: 10.1016/0014-4827(78)90081-2 |
0.508 |
|
| 1978 |
Anderson RG, Goldstein JL, Brown MS. A mutation that impairs the ability of lipoprotein receptors to localise in coated pits on the cell surface of human fibroblasts. Nature. 270: 695-9. PMID 201867 DOI: 10.1038/270695a0 |
0.534 |
|
| 1978 |
Reichl D, Myant NB, Brown MS, Goldstein JL. Biologically active low density lipoprotein in human peripheral lymph. The Journal of Clinical Investigation. 61: 64-71. PMID 201669 DOI: 10.1172/JCI108926 |
0.431 |
|
| 1978 |
Goldstein JL, Brown MS, Stone NJ. Genetics of the LDL receptor: evidence that the mutations affecting binding and internalization are allelic. Cell. 12: 629-41. PMID 200368 DOI: 10.1016/0092-8674(77)90263-X |
0.525 |
|
| 1978 |
Brown M, Goldstein J, Vandenberghe K, Fryns J, Kovanen P, Eeckels R, Berghe HVD, Cassiman J. PRENATAL DIAGNOSIS OF HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLÆMIA. Expression of a Genetic Receptor Disease in Utero The Lancet. 311: 526-529. PMID 76071 DOI: 10.1016/S0140-6736(78)90552-4 |
0.306 |
|
| 1978 |
Ho Y, Smith R, Brown M, Goldstein J. Low-density lipoprotein (LDL) receptor activity in human acute myelogenous leukemia cells Blood. 52: 1099-1114. DOI: 10.1182/BLOOD.V52.6.1099.BLOODJOURNAL5261099 |
0.563 |
|
| 1978 |
Brown M, Faust J, Goldstein J, Kaneko I, Endo A. Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase Journal of Biological Chemistry. 253: 1121-1128. DOI: 10.1016/s0021-9258(17)38120-6 |
0.309 |
|
| 1977 |
Goldstein JL, Brown MS. Atherosclerosis: the low-density lipoprotein receptor hypothesis. Metabolism: Clinical and Experimental. 26: 1257-75. PMID 198627 DOI: 10.1016/0026-0495(77)90119-6 |
0.588 |
|
| 1977 |
Goldstein JL, Brown MS. The low-density lipoprotein pathway and its relation to atherosclerosis. Annual Review of Biochemistry. 46: 897-930. PMID 197883 DOI: 10.1146/ANNUREV.BI.46.070177.004341 |
0.568 |
|
| 1977 |
Brown MS, Anderson RG, Goldstein JL. Mutations affecting the binding, internalization, and lysosomal hydrolysis of low density lipoprotein in cultured human fibroblasts, lymphocytes, and aortic smooth muscle cells. Journal of Supramolecular Structure. 6: 85-94. PMID 197319 DOI: 10.1002/JSS.400060107 |
0.552 |
|
| 1977 |
Basu S, Anderson R, Goldstein J, Brown. Metabolism of cationized lipoproteins by human fibroblasts. Biochemical and morphologic correlations. Journal of Cell Biology. 74: 119-135. PMID 194905 DOI: 10.1083/Jcb.74.1.119 |
0.476 |
|
| 1977 |
Brown MS, Goldstein JL. Human mutations affecting the low density lipoprotein pathway. The American Journal of Clinical Nutrition. 30: 975-8. PMID 194472 DOI: 10.1093/AJCN/30.6.975 |
0.476 |
|
| 1977 |
Ho Y, Faust, Bilheimer D, Brown, Goldstein J. Regulation of cholesterol synthesis by low density lipoprotein in isolated human lymphocytes Journal of Experimental Medicine. 145: 1531-1549. PMID 194011 DOI: 10.1084/Jem.145.6.1531 |
0.451 |
|
| 1977 |
Goldstein JL, Anderson RG, Buja LM, Basu SK, Brown MS. Overloading human aortic smooth muscle cells with low density lipoprotein-cholesteryl esters reproduces features of atherosclerosis in vitro. The Journal of Clinical Investigation. 59: 1196-202. PMID 193874 DOI: 10.1172/JCI108744 |
0.515 |
|
| 1977 |
Anderson RG, Brown MS, Goldstein JL. Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts. Cell. 10: 351-64. PMID 191195 DOI: 10.1016/0092-8674(77)90022-8 |
0.532 |
|
| 1977 |
Dana SE, Brown MS, Goldstein JL. Specific, saturable, and high affinity binding of 125I-low density lipoprotein to glass beads. Biochemical and Biophysical Research Communications. 74: 1369-76. PMID 191022 DOI: 10.1016/0006-291X(77)90593-9 |
0.531 |
|
| 1977 |
Brown MS, Goldstein JL. Analysis of a mutant strain of human fibroblasts with a defect in the internalization of receptor-bound low density lipoprotein. Cell. 9: 663-74. PMID 189940 DOI: 10.1016/0092-8674(76)90130-6 |
0.574 |
|
| 1977 |
Brown MS, Ho YK, Goldstein JL. The low-density lipoprotein pathway in human fibroblasts: relation between cell surface receptor binding and endocytosis of low-density lipoprotein. Annals of the New York Academy of Sciences. 275: 244-57. PMID 188367 DOI: 10.1111/j.1749-6632.1976.tb43358.x |
0.59 |
|
| 1977 |
Goldstein JL, Brown MS. The LDL pathway in human fibroblasts: a receptor-mediated mechanism for the regulation of cholesterol metabolism. Current Topics in Cellular Regulation. 11: 147-81. PMID 187385 DOI: 10.1016/B978-0-12-152811-9.50011-0 |
0.518 |
|
| 1977 |
Ho YK, Brown S, Bilheimer DW, Goldstein JL. Regulation of low density lipoprotein receptor activity in freshly isolated human lymphocytes. The Journal of Clinical Investigation. 58: 1465-74. PMID 186492 DOI: 10.1172/JCI108603 |
0.395 |
|
| 1977 |
Balasubramaniam S, Goldstein JL, Brown MS. Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities. Proceedings of the National Academy of Sciences of the United States of America. 74: 1421-5. PMID 16260 DOI: 10.1073/PNAS.74.4.1421 |
0.522 |
|
| 1977 |
Balasubramaniam S, Goldstein JL, Faust JR, Brunschede GY, Brown MS. Lipoprotein-mediated regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesteryl ester metabolism in the adrenal gland of the rat. Journal of Biological Chemistry. 252: 1771-1779. DOI: 10.1016/s0021-9258(17)40617-x |
0.376 |
|
| 1977 |
Faust JR, Goldstein JL, Brown MS. Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured mouse adrenal cells. Journal of Biological Chemistry. 252: 4861-4871. DOI: 10.1016/s0021-9258(17)40133-5 |
0.497 |
|
| 1976 |
Balasubramaniam S, Goldstein JL, Faust JR, Brown MS. Evidence for regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in nonhepatic tissues of rat. Proceedings of the National Academy of Sciences of the United States of America. 73: 2564-8. PMID 1066664 DOI: 10.1073/PNAS.73.8.2564 |
0.521 |
|
| 1976 |
Brown MS, Dana SE, Goldstein JL. Receptor-dependent hydrolysis of cholesteryl esters contained in plasma low density lipoprotein. Proceedings of the National Academy of Sciences of the United States of America. 72: 2925-9. PMID 241998 DOI: 10.1073/PNAS.72.8.2925 |
0.579 |
|
| 1976 |
Goldstein JL, Sobhani MK, Faust JR, Brown MS. Heterozygous familial hypercholesterolemia: failure of normal allele to compensate for mutant allele at a regulated genetic locus. Cell. 9: 195-203. PMID 184960 DOI: 10.1016/0092-8674(76)90110-0 |
0.578 |
|
| 1976 |
Basu SK, Goldstein JL, Anderson GW, Brown MS. Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 73: 3178-82. PMID 184464 DOI: 10.1073/pnas.73.9.3178 |
0.57 |
|
| 1976 |
Ho YK, Brown MS, Kayden HJ, Goldstein JL. Binding, internalization, and hydrolysis of low density lipoprotein in long-term lymphoid cell lines from a normal subject and a patient with homozygous familial hypercholesterolemia. The Journal of Experimental Medicine. 144: 444-55. PMID 182894 DOI: 10.1084/JEM.144.2.444 |
0.583 |
|
| 1976 |
Anderson RG, Goldstein JL, Brown MS. Localization of low density lipoprotein receptors on plasma membrane of normal human fibroblasts and their absence in cells from a familial hypercholesterolemia homozygote. Proceedings of the National Academy of Sciences of the United States of America. 73: 2434-8. PMID 181751 DOI: 10.1073/PNAS.73.7.2434 |
0.56 |
|
| 1976 |
Goldstein JL, Basu SK, Brunschede GY, Brown MS. Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans. Cell. 7: 85-95. PMID 181140 DOI: 10.1016/0092-8674(76)90258-0 |
0.537 |
|
| 1976 |
Brown MS, Goldstein JL. Familial hypercholesterolemia: A genetic defect in the low-density lipoprotein receptor. The New England Journal of Medicine. 294: 1386-90. PMID 177875 DOI: 10.1056/NEJM197606172942509 |
0.485 |
|
| 1976 |
Brown MS, Goldstein JL. Receptor-mediated control of cholesterol metabolism. Science (New York, N.Y.). 191: 150-4. PMID 174194 DOI: 10.1126/SCIENCE.174194 |
0.52 |
|
| 1976 |
Goldstein JL, Faust JR, Brunschede GY, Brown MS. Steroid requirements for suppression of HMG CoA reductase activity in cultured human fibroblasts. Advances in Experimental Medicine and Biology. 63: 77-84. PMID 173156 DOI: 10.1007/978-1-4684-3258-9_5 |
0.59 |
|
| 1976 |
Brown MS, Goldstein JL. Lipoprotein receptors and genetic control of cholesterol metabolism in cultured human cells. Die Naturwissenschaften. 62: 385-9. PMID 172803 DOI: 10.1007/BF00625346 |
0.483 |
|
| 1976 |
Bilheimer DW, Goldstein JL, Grundy SM, Brown MS. Reduction in cholesterol and low density lipoprotein synthesis after portacaval shunt surgery in a patient with homozygous familial hypercholesterolemia. The Journal of Clinical Investigation. 56: 1420-30. PMID 172531 DOI: 10.1172/JCI108223 |
0.542 |
|
| 1976 |
Brown MS, Goldstein JL. The low density lipoprotein pathway in human fibroblasts Trends in Biochemical Sciences. 1: 193-195. DOI: 10.1016/S0968-0004(76)80027-8 |
0.553 |
|
| 1975 |
Goldstein JL, Dana SE, Brown MS. Esterification of low density lipoprotein cholesterol in human fibroblasts and its absence in homozygous familial hypercholesterolemia. Proceedings of the National Academy of Sciences of the United States of America. 71: 4288-92. PMID 4373706 DOI: 10.1073/PNAS.71.11.4288 |
0.576 |
|
| 1975 |
Harrod MJE, Brown MS, Weinberg AG, Harkness WN, Goldstein JL. Familial pseudomembranous colitis and its relation to lincomycin therapy The American Journal of Digestive Diseases. 20: 808-812. PMID 1163517 DOI: 10.1007/BF01070948 |
0.377 |
|
| 1975 |
Goldstein JL, Dana SE, Brunschede GY, Brown MS. Genetic heterogeneity in familial hypercholesterolemia: evidence for two different mutations affecting functions of low-density lipoprotein receptor. Proceedings of the National Academy of Sciences of the United States of America. 72: 1092-6. PMID 236556 DOI: 10.1073/PNAS.72.3.1092 |
0.574 |
|
| 1975 |
Goldstein JL, Brown MS, Greene AE, Coriell LL. Homozygous familial hypercholesterolemia (receptor negative type). Repository identification No. GM 361 Cytogenetics and Cell Genetics. 15: 357-359. PMID 177249 DOI: 10.1159/000130531 |
0.443 |
|
| 1975 |
Brown MS, Faust JR, Goldstein JL. Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts. The Journal of Clinical Investigation. 55: 783-93. PMID 164482 DOI: 10.1172/JCI107989 |
0.592 |
|
| 1975 |
Brown MS, Brannan PG, Bohmfalk HA, Brunschede GY, Dana SE, Helgeson J, Goldstein JL. Use of mutant fibroblasts in the analysis of the regulation of cholesterol metabolism in human cells. Journal of Cellular Physiology. 85: 425-36. PMID 164479 DOI: 10.1002/jcp.1040850409 |
0.588 |
|
| 1975 |
Goldstein JL, Brown MS. Familial hypercholesterolemia. A genetic regulatory defect in cholesterol metabolism. The American Journal of Medicine. 58: 147-50. PMID 163579 DOI: 10.1016/0002-9343(75)90563-X |
0.469 |
|
| 1975 |
Hoehn H, Bryant EM, Au K, Norwood TH, Boman H, Martin GM, Chern CJ, Croce CM, Wurster-Hill DH, Gray CW, Diamond JR, Dunn HO, Howell WM, Cohen MM, Shaham M, ... ... Goldstein JL, et al. Data on cytogenetic registers Cytogenetic and Genome Research. 15: 281-281. DOI: 10.1159/000130525 |
0.342 |
|
| 1975 |
Brown M, Brunschede G, Goldstein J. Inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro. An adenine nucleotide-dependent reaction catalyzed by a factor in human fibroblasts. Journal of Biological Chemistry. 250: 2502-2509. DOI: 10.1016/s0021-9258(19)41629-3 |
0.311 |
|
| 1975 |
Brown M, Dana S, Goldstein J. Cholesterol ester formation in cultured human fibroblasts. Stimulation by oxygenated sterols. Journal of Biological Chemistry. 250: 4025-4027. DOI: 10.1016/s0021-9258(19)41498-1 |
0.369 |
|
| 1975 |
Goldstein J, Brunschede G, Brown M. Inhibition of proteolytic degradation of low density lipoprotein in human fibroblasts by chloroquine, concanavalin A, and Triton WR 1339. Journal of Biological Chemistry. 250: 7854-7862. DOI: 10.1016/s0021-9258(19)40894-6 |
0.427 |
|
| 1975 |
Goldstein J, Dana S, Faust J, Beaudet A, Brown M. Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease. Journal of Biological Chemistry. 250: 8487-8495. DOI: 10.1016/s0021-9258(19)40786-2 |
0.4 |
|
| 1974 |
Goldstein JL, Albers JJ, Schrott HG, Hazzard WR, Bierman EL, Motulsky AG. Plasma lipid levels and coronary heart disease in adult relatives of newborns with normal and elevated cord blood lipids. American Journal of Human Genetics. 26: 727-35. PMID 4440681 |
0.457 |
|
| 1974 |
Brown MS, Goldstein JL. Expression of the familial hypercholesterolemia gene in heterozygotes: mechanism for a dominant disorder in man. Science (New York, N.Y.). 185: 61-3. PMID 4366052 DOI: 10.1126/science.185.4145.61 |
0.584 |
|
| 1974 |
Brown MS, Goldstein JL. Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. Proceedings of the National Academy of Sciences of the United States of America. 71: 788-92. PMID 4362634 DOI: 10.1073/PNAS.71.3.788 |
0.556 |
|
| 1974 |
Ott J, Schrott HG, Goldstein JL, Hazzard WR, Allen FH, Falk CT, Motulsky AG. Linkage studies in a large kindred with familial hypercholesterolemia. American Journal of Human Genetics. 26: 598-603. PMID 4213615 |
0.404 |
|
| 1974 |
Brown MS, Dana SE, Goldstein JL. Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity in Cultured Human Fibroblasts Journal of Biological Chemistry. 249: 789-796. DOI: 10.1016/s0021-9258(19)42998-0 |
0.325 |
|
| 1974 |
Goldstein JL, Brown MS. Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts Journal of Biological Chemistry. 249: 5153-5162. DOI: 10.1016/s0021-9258(19)42341-7 |
0.421 |
|
| 1974 |
Brown MS, Goldstein JL. Suppression of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity and Inhibition of Growth of Human Fibroblasts by 7-Ketocholesterol Journal of Biological Chemistry. 249: 7306-7314. DOI: 10.1016/s0021-9258(19)42106-6 |
0.309 |
|
| 1973 |
Goldstein JL, Schrott HG, Hazzard WR, Bierman EL, Motulsky AG. Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia. The Journal of Clinical Investigation. 52: 1544-68. PMID 4718953 DOI: 10.1172/Jci107332 |
0.551 |
|
| 1973 |
Goldstein JL, Hazzard WR, Schrott HG, Bierman EL, Motulsky AG. Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction. The Journal of Clinical Investigation. 52: 1533-43. PMID 4718952 DOI: 10.1172/Jci107331 |
0.533 |
|
| 1973 |
Goldstein JL, Brown MS. Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol. Proceedings of the National Academy of Sciences of the United States of America. 70: 2804-8. PMID 4355366 DOI: 10.1073/PNAS.70.10.2804 |
0.506 |
|
| 1973 |
Brown MS, Dana SE, Goldstein JL. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by lipoproteins. Proceedings of the National Academy of Sciences of the United States of America. 70: 2162-6. PMID 4352976 DOI: 10.1073/PNAS.70.7.2162 |
0.515 |
|
| 1973 |
Hazzard WR, Goldstein JL, Schrott MG, Motulsky AG, Bierman EL. Hyperlipidemia in coronary heart disease. 3. Evaluation of lipoprotein phenotypes of 156 genetically defined survivors of myocardial infarction. The Journal of Clinical Investigation. 52: 1569-77. PMID 4352458 DOI: 10.1172/Jci107333 |
0.576 |
|
| 1972 |
Goldstein JL, Caskey CT. Peptide chain termination: effect of protein S on ribosomal binding of release factors. Proceedings of the National Academy of Sciences of the United States of America. 67: 537-43. PMID 5289007 DOI: 10.1073/PNAS.67.2.537 |
0.41 |
|
| 1972 |
Schrott HG, Goldstein JL, Hazzard WR, McGoodwin MM, Motulsky AG. Familial hypercholesterolemia in a large indred. Evidence for a monogenic mechanism. Annals of Internal Medicine. 76: 711-20. PMID 5025321 DOI: 10.7326/0003-4819-76-5-711 |
0.475 |
|
| 1972 |
Goldstein JL, Hazzard WR, Schrott HG, Bierman EL, Motulsky AG. Genetics of hyperlipidemia in coronary heart disease. Transactions of the Association of American Physicians. 85: 120-38. PMID 4349620 |
0.382 |
|
| 1970 |
Goldstein JL, Beaudet AL, Caskey CT. Peptide chain termination with mammalian release factor. Proceedings of the National Academy of Sciences of the United States of America. 67: 99-106. PMID 4917818 DOI: 10.1073/PNAS.67.1.99 |
0.532 |
|
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