| Year |
Citation |
Score |
| 2023 |
Munari L, Patel V, Johnson N, Mariottini C, Prabha S, Blitzer RD, Iyengar R. Memory discrimination is promoted by the expression of the transcription repressor WT1 in the dentate gyrus. Frontiers in Behavioral Neuroscience. 17: 1130840. PMID 37830039 DOI: 10.3389/fnbeh.2023.1130840 |
0.599 |
|
| 2023 |
Siddiq MM, Johnson NP, Zorina Y, Yadaw AS, Toro CA, Hansen J, Rabinovich V, Gregorich SM, Xiong Y, Tolentino RE, Hannila SS, Kaplan E, Blitzer RD, Filbin MT, Cardozo CP, ... ... Iyengar R, et al. A spatially specified systems pharmacology therapy for axonal recovery after injury. Frontiers in Pharmacology. 14: 1225759. PMID 37799971 DOI: 10.3389/fphar.2023.1225759 |
0.768 |
|
| 2023 |
Siddiq MM, Toro CA, Johnson NP, Hansen J, Xiong Y, Mellado W, Tolentino RE, Johnson K, Jayaraman G, Suhail Z, Harlow L, Dai J, Beaumont KG, Sebra R, Willis DE, ... ... Iyengar R, et al. Spinal cord injury regulates circular RNA expression in axons. Frontiers in Molecular Neuroscience. 16: 1183315. PMID 37692100 DOI: 10.3389/fnmol.2023.1183315 |
0.504 |
|
| 2023 |
Shim JV, Xiong Y, Dhanan P, Dariolli R, Azeloglu EU, Hu B, Jayaraman G, Schaniel C, Birtwistle MR, Iyengar R, Dubois NC, Sobie EA. Predicting individual-specific cardiotoxicity responses induced by tyrosine kinase inhibitors. Frontiers in Pharmacology. 14: 1158222. PMID 37101545 DOI: 10.3389/fphar.2023.1158222 |
0.731 |
|
| 2023 |
Ferkowicz MJ, Winfree S, Sabo AR, Kamocka MM, Khochare S, Barwinska D, Eadon MT, Cheng YH, Phillips CL, Sutton TA, Kelly KJ, Dagher PC, El-Achkar TM, Dunn KW, Knight R, ... ... Iyengar R, et al. Large-scale, three-dimensional tissue cytometry of the human kidney: a complete and accessible pipeline. Laboratory Investigation; a Journal of Technical Methods and Pathology. 101: 661-676. PMID 36775387 DOI: 10.1038/s41374-020-00518-w |
0.566 |
|
| 2022 |
Hansen J, Siddiq MM, Yadaw AS, Tolentino RE, Rabinovich V, Jayaraman G, Jain MR, Liu T, Li H, Xiong Y, Goldfarb J, Iyengar R. Whole cell response to receptor stimulation involves many deep and distributed subcellular biochemical processes. The Journal of Biological Chemistry. 102325. PMID 35926710 DOI: 10.1016/j.jbc.2022.102325 |
0.626 |
|
| 2022 |
Hansen J, Sealfon R, Menon R, Eadon MT, Lake BB, Steck B, Anjani K, Parikh S, Sigdel TK, Zhang G, Velickovic D, Barwinska D, Alexandrov T, Dobi D, Rashmi P, ... ... Iyengar R, et al. A reference tissue atlas for the human kidney. Science Advances. 8: eabn4965. PMID 35675394 DOI: 10.1126/sciadv.abn4965 |
0.726 |
|
| 2022 |
Xiong Y, Liu T, Chen T, Hansen J, Hu B, Chen Y, Jayaraman G, Schürer S, Vidovic D, Goldfarb J, Sobie EA, Birtwistle MR, Iyengar R, Li H, Azeloglu EU. Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity. Scientific Data. 9: 18. PMID 35058449 DOI: 10.1038/s41597-021-01114-3 |
0.729 |
|
| 2021 |
Siddiq MM, Hannila SS, Zorina Y, Nikulina E, Rabinovich V, Hou J, Huq R, Richman EL, Tolentino RE, Hansen J, Velenosi A, Kwon BK, Tsirka SE, Maze I, Sebra R, ... ... Iyengar R, et al. Extracellular histones, a new class of inhibitory molecules of CNS axonal regeneration. Brain Communications. 3: fcab271. PMID 34993473 DOI: 10.1093/braincomms/fcab271 |
0.757 |
|
| 2021 |
Schaniel C, Dhanan P, Hu B, Xiong Y, Raghunandan T, Gonzalez DM, Dariolli R, D'Souza SL, Yadaw AS, Hansen J, Jayaraman G, Mathew B, Machado M, Berger SI, Tripodig J, ... ... Iyengar R, et al. A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals. Stem Cell Reports. PMID 34739849 DOI: 10.1016/j.stemcr.2021.10.005 |
0.772 |
|
| 2021 |
Siddiq MM, Chan AT, Miorin L, Yadaw AS, Beaumont KG, Kehrer T, Cupic A, White KM, Tolentino RE, Hu B, Stern AD, Tavassoly I, Hansen J, Sebra R, Martinez P, ... ... Iyengar R, et al. Functional Effects of Cardiomyocyte Injury in COVID-19. Journal of Virology. JVI0106321. PMID 34669512 DOI: 10.1128/JVI.01063-21 |
0.679 |
|
| 2021 |
Rahman R, Zatorski N, Hansen J, Xiong Y, van Hasselt JGC, Sobie EA, Birtwistle MR, Azeloglu EU, Iyengar R, Schlessinger A. Protein structure-based gene expression signatures. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33941686 DOI: 10.1073/pnas.2014866118 |
0.711 |
|
| 2021 |
de Boer IH, Alpers CE, Azeloglu EU, Balis UGJ, Barasch JM, Barisoni L, Blank KN, Bomback AS, Brown K, Dagher PC, Dighe AL, Eadon MT, El-Achkar TM, Gaut JP, Hacohen N, ... ... Iyengar R, et al. Rationale and design of the Kidney Precision Medicine Project. Kidney International. 99: 498-510. PMID 33637194 DOI: 10.1016/j.kint.2020.08.039 |
0.562 |
|
| 2020 |
Siddiq MM, Chan AT, Miorin L, Yadaw AS, Beaumont KG, Kehrer T, White KM, Cupic A, Tolentino RE, Hu B, Stern AD, Tavassoly I, Hansen J, Martinez P, Dubois N, ... ... Iyengar R, et al. Physiology of cardiomyocyte injury in COVID-19. Medrxiv : the Preprint Server For Health Sciences. PMID 33200140 DOI: 10.1101/2020.11.10.20229294 |
0.674 |
|
| 2020 |
El-Achkar TM, Eadon MT, Menon R, Lake BB, Sigdel TK, Alexandrov T, Parikh S, Zhang G, Dobib D, Dunn KW, Otto EA, Anderton CR, Carson JM, Luo J, Park C, ... ... Iyengar R, et al. A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: Guidelines from the Kidney Precision Medicine Project. Physiological Genomics. PMID 33197228 DOI: 10.1152/physiolgenomics.00104.2020 |
0.571 |
|
| 2020 |
van Hasselt JGC, Rahman R, Hansen J, Stern A, Shim JV, Xiong Y, Pickard A, Jayaraman G, Hu B, Mahajan M, Gallo JM, Goldfarb J, Sobie EA, Birtwistle MR, Schlessinger A, ... ... Iyengar R, et al. Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity. Nature Communications. 11: 4809. PMID 32968055 DOI: 10.1038/s41467-020-18396-7 |
0.726 |
|
| 2019 |
Mariottini C, Munari L, Gunzel E, Seco JM, Tzavaras N, Hansen J, Stern SA, Gao V, Aleyasin H, Sharma A, Azeloglu EU, Hodes GE, Russo SJ, Huff V, Birtwistle MR, ... ... Iyengar R, et al. Wilm's tumor 1 promotes memory flexibility. Nature Communications. 10: 3756. PMID 31434897 DOI: 10.1038/S41467-019-11781-X |
0.725 |
|
| 2019 |
Cugno A, Bartol TM, Sejnowski TJ, Iyengar R, Rangamani P. Geometric principles of second messenger dynamics in dendritic spines. Scientific Reports. 9: 11676. PMID 31406140 DOI: 10.1038/S41598-019-48028-0 |
0.558 |
|
| 2019 |
Hansen J, Galatioto J, Caescu CI, Arnaud P, Calizo RC, Spronck B, Murtada SI, Borkar R, Weinberg A, Azeloglu EU, Bintanel-Morcillo M, Gallo JM, Humphrey JD, Jondeau G, Boileau C, ... ... Iyengar R, et al. Systems pharmacology-based integration of human and mouse data for drug repurposing to treat thoracic aneurysms. Jci Insight. 4. PMID 31167969 DOI: 10.1172/Jci.Insight.127652 |
0.623 |
|
| 2019 |
Tavassoly I, Hu Y, Zhao S, Mariottini C, Boran A, Chen Y, Li L, Tolentino RE, Jayaraman G, Goldfarb J, Gallo J, Iyengar R. Genomic signatures defining responsiveness to allopurinol and combination therapy for lung cancer identified by systems therapeutics analyses. Molecular Oncology. PMID 31116490 DOI: 10.1002/1878-0261.12521 |
0.743 |
|
| 2019 |
Rangamani P, Bell M, Cugno A, Ohadi D, Bartol TM, Iyengar R, Sejnowski TJ. Dendritic Spine Geometry and Ultrastructure Dictate the Spatiotemporal Dynamics of Second Messengers Biophysical Journal. 116: 304a. DOI: 10.1016/J.Bpj.2018.11.1651 |
0.533 |
|
| 2018 |
Tavassoly I, Goldfarb J, Iyengar R. Systems biology primer: the basic methods and approaches. Essays in Biochemistry. PMID 30287586 DOI: 10.1042/Ebc20180003 |
0.716 |
|
| 2018 |
Koch RJ, Barrette AM, Stern AD, Hu B, Bouhaddou M, Azeloglu EU, Iyengar R, Birtwistle MR. Validating Antibodies for Quantitative Western Blot Measurements with Microwestern Array. Scientific Reports. 8: 11329. PMID 30054510 DOI: 10.1038/S41598-018-29436-0 |
0.584 |
|
| 2018 |
Galatioto J, Caescu CI, Hansen J, Cook J, Miramontes I, Iyengar R, Ramirez F. Cell Type-Specific Contributions of the Angiotensin II Type 1a Receptor to Aorta Homeostasis and Aneurysmal Disease. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 29371244 DOI: 10.1161/Atvbaha.117.310609 |
0.323 |
|
| 2018 |
Keenan AB, Jenkins SL, Jagodnik KM, Koplev S, He E, Torre D, Wang Z, Dohlman AB, Silverstein MC, Lachmann A, Kuleshov MV, Ma'ayan A, Stathias V, Terryn R, Cooper D, ... ... Iyengar R, et al. The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations. Cell Systems. 6: 13-24. PMID 29199020 DOI: 10.1016/J.Cels.2017.11.001 |
0.757 |
|
| 2018 |
Tavassoly I, Iyengar R. Abstract 4276: Analysis of sensitivity of genomic signatures of therapeutic responses of non-small cell lung cancer in patient-derived xenograft models Cancer Research. 78: 4276-4276. DOI: 10.1158/1538-7445.Am2018-4276 |
0.702 |
|
| 2017 |
Hansen J, Meretzky D, Woldesenbet S, Stolovitzky G, Iyengar R. A flexible ontology for inference of emergent whole cell function from relationships between subcellular processes. Scientific Reports. 7: 17689. PMID 29255142 DOI: 10.1038/S41598-017-16627-4 |
0.332 |
|
| 2017 |
Ron A, Azeloglu EU, Calizo RC, Hu M, Bhattacharya S, Chen Y, Jayaraman G, Lee S, Neves-Zaph SR, Li H, Gordon RE, He JC, Hone JC, Iyengar R. Cell shape information is transduced through tension-independent mechanisms. Nature Communications. 8: 2145. PMID 29247198 DOI: 10.1038/S41467-017-02218-4 |
0.65 |
|
| 2017 |
Xiong Y, Soumillon M, Wu J, Hansen J, Hu B, van Hasselt JGC, Jayaraman G, Lim R, Bouhaddou M, Ornelas L, Bochicchio J, Lenaeus L, Stocksdale J, Shim J, Gomez E, ... ... Iyengar R, et al. A Comparison of mRNA Sequencing with Random Primed and 3'-Directed Libraries. Scientific Reports. 7: 14626. PMID 29116112 DOI: 10.1038/S41598-017-14892-X |
0.718 |
|
| 2017 |
Falkenberg CV, Azeloglu EU, Stothers M, Deerinck TJ, Chen Y, He JC, Ellisman MH, Hone JC, Iyengar R, Loew LM. Fragility of foot process morphology in kidney podocytes arises from chaotic spatial propagation of cytoskeletal instability. Plos Computational Biology. 13: e1005433. PMID 28301477 DOI: 10.1371/Journal.Pcbi.1005433 |
0.623 |
|
| 2017 |
Hu M, Azeloglu EU, Ron A, Tran-Ba KH, Calizo RC, Tavassoly I, Bhattacharya S, Jayaraman G, Chen Y, Rabinovich V, Iyengar R, Hone JC, He JC, Kaufman LJ. A biomimetic gelatin-based platform elicits a pro-differentiation effect on podocytes through mechanotransduction. Scientific Reports. 7: 43934. PMID 28262745 DOI: 10.1038/Srep43934 |
0.783 |
|
| 2017 |
Tavassoly I, Iyengar R. Abstract 5554: Metabolic reprogramming in non-small cell lung cancer: a precision oncology approach Cancer Research. 77: 5554-5554. DOI: 10.1158/1538-7445.Am2017-5554 |
0.686 |
|
| 2016 |
Dohlman A, Zaman S, Duan Q, Wang Z, Iyengar R, Abernethy D, Ma'ayan A. Predicting adverse cardiovascular events for tyrosine kinase inhibitors from molecular features F1000research. 5. DOI: 10.7490/F1000Research.1113434.1 |
0.764 |
|
| 2016 |
Smet MD, Doisne N, Stillitano F, Lissoni A, Wang N, Leybaert L, Grauso M, Mougenot N, Clergue M, Coulombe A, Guicheney P, Neyroud N, Kong C, Hansen J, Funck-Brentano C, ... ... Iyengar R, et al. Control of Rhythm and Rate278Cx43 hemichannels in ventricular cardiomyocytes can be activated by an elevation of cytoplasmic Ca2+ through a CaM-dependent signaling cascade and are a potent contributor to cardiac arrhythmogenesis279Exploration of the dominant-negative effect of a SCN5A mutation in mice using adeno-associated viruses280Modeling susceptibility to drug-induced long qt syndrome with a panel of subject-specific induced pluripotent stem cells Cardiovascular Research. 111. DOI: 10.1093/Cvr/Cvw140 |
0.302 |
|
| 2016 |
Shim JV, Birtwistle MR, Iyengar R, Sobie EA. Integrated Analysis for Quantitative Predictions of Drug Induced Cardiotoxicity Biophysical Journal. 110: 476a-477a. DOI: 10.1016/J.Bpj.2015.11.2549 |
0.373 |
|
| 2015 |
Iyengar R. Can intracellular cAMP dynamics enable scalable computation? Frontiers in Cellular Neuroscience. 9: 112. PMID 25870541 DOI: 10.3389/fncel.2015.00112 |
0.346 |
|
| 2015 |
Azeloglu EU, Iyengar R. Good practices for building dynamical models in systems biology. Science Signaling. 8: fs8. PMID 25852187 DOI: 10.1126/Scisignal.Aab0880 |
0.625 |
|
| 2015 |
Azeloglu EU, Iyengar R. Signaling networks: information flow, computation, and decision making. Cold Spring Harbor Perspectives in Biology. 7: a005934. PMID 25833842 DOI: 10.1101/Cshperspect.A005934 |
0.656 |
|
| 2014 |
Rangamani P, Xiong GY, Iyengar R. Multiscale modeling of cell shape from the actin cytoskeleton. Progress in Molecular Biology and Translational Science. 123: 143-67. PMID 24560144 DOI: 10.1016/B978-0-12-397897-4.00002-4 |
0.577 |
|
| 2014 |
Azeloglu EU, Hardy SV, Eungdamrong NJ, Chen Y, Jayaraman G, Chuang PY, Fang W, Xiong H, Neves SR, Jain MR, Li H, Ma'ayan A, Gordon RE, He JC, Iyengar R. Interconnected network motifs control podocyte morphology and kidney function. Science Signaling. 7: ra12. PMID 24497609 DOI: 10.1126/Scisignal.2004621 |
0.806 |
|
| 2014 |
Karakikes I, Senyei GD, Hansen J, Kong CW, Azeloglu EU, Stillitano F, Lieu DK, Wang J, Ren L, Hulot JS, Iyengar R, Li RA, Hajjar RJ. Small molecule-mediated directed differentiation of human embryonic stem cells toward ventricular cardiomyocytes. Stem Cells Translational Medicine. 3: 18-31. PMID 24324277 DOI: 10.5966/Sctm.2013-0110 |
0.63 |
|
| 2014 |
Iyengar R, He JC, VanHook AM. Science Signaling Podcast: 4 February 2014 Science Signaling. 7: pc4-pc4. DOI: 10.1126/Scisignal.2005106 |
0.306 |
|
| 2013 |
Zhao S, Nishimura T, Chen Y, Azeloglu EU, Gottesman O, Giannarelli C, Zafar MU, Benard L, Badimon JJ, Hajjar RJ, Goldfarb J, Iyengar R. Systems pharmacology of adverse event mitigation by drug combinations. Science Translational Medicine. 5: 206ra140. PMID 24107779 DOI: 10.1126/Scitranslmed.3006548 |
0.665 |
|
| 2013 |
Rangamani P, Lipshtat A, Azeloglu EU, Calizo RC, Hu M, Ghassemi S, Hone J, Scarlata S, Neves SR, Iyengar R. Decoding information in cell shape. Cell. 154: 1356-69. PMID 24034255 DOI: 10.1016/J.Cell.2013.08.026 |
0.796 |
|
| 2013 |
Rangamani P, Lipshtat A, Azeloglu E, Calizo R, Scarlata S, Neves S, Iyengar R. Cell Shape can Dynamically Process Information during Signal Flow in Regulatory Pathways Biophysical Journal. 104: 613a. DOI: 10.1016/J.Bpj.2012.11.3397 |
0.802 |
|
| 2012 |
Boran AD, Seco J, Jayaraman V, Jayaraman G, Zhao S, Reddy S, Chen Y, Iyengar R. A potential peptide therapeutic derived from the juxtamembrane domain of the epidermal growth factor receptor. Plos One. 7: e49702. PMID 23166750 DOI: 10.1371/Journal.Pone.0049702 |
0.457 |
|
| 2012 |
Iyengar R, Zhao S, Chung SW, Mager DE, Gallo JM. Merging systems biology with pharmacodynamics. Science Translational Medicine. 4: 126ps7. PMID 22440734 DOI: 10.1126/Scitranslmed.3003563 |
0.462 |
|
| 2012 |
Hwangpo TA, Jordan JD, Premsrirut PK, Jayamaran G, Licht JD, Iyengar R, Neves SR. G Protein-regulated inducer of neurite outgrowth (GRIN) modulates Sprouty protein repression of mitogen-activated protein kinase (MAPK) activation by growth factor stimulation. The Journal of Biological Chemistry. 287: 13674-85. PMID 22383529 DOI: 10.1074/Jbc.M111.320705 |
0.73 |
|
| 2012 |
Zhao S, Iyengar R. Systems pharmacology: network analysis to identify multiscale mechanisms of drug action. Annual Review of Pharmacology and Toxicology. 52: 505-21. PMID 22235860 DOI: 10.1146/Annurev-Pharmtox-010611-134520 |
0.474 |
|
| 2012 |
He JC, Chuang PY, Ma'ayan A, Iyengar R. Systems biology of kidney diseases. Kidney International. 81: 22-39. PMID 21881558 DOI: 10.1038/Ki.2011.314 |
0.529 |
|
| 2012 |
Azeloglu EU, Stothers M, Deerinck TJ, Falkenberg C, Chen Y, He JC, Hone JC, Loew LM, Ellisman MH, Iyengar R. 3-D quantitative microanatomy of rat kidney podocytes as determined by serial block-face scanning electron microscopy Asme 2012 Summer Bioengineering Conference, Sbc 2012. 1213-1214. DOI: 10.1115/SBC2012-80650 |
0.537 |
|
| 2012 |
Falkenberg CV, Blinov ML, Azeloglu EU, Neves SR, Iyengar R, Loew LM. A Mathematical Model for Nephrin Localization in Podocyte Foot Processes Biophysical Journal. 102: 593a-594a. DOI: 10.1016/J.Bpj.2011.11.3235 |
0.796 |
|
| 2011 |
Hansen J, Zhao S, Iyengar R. Systems pharmacology of complex diseases. Annals of the New York Academy of Sciences. 1245: E1-5. PMID 22417173 DOI: 10.1111/J.1749-6632.2011.06382.X |
0.452 |
|
| 2011 |
Mazloom AR, Dannenfelser R, Clark NR, Grigoryan AV, Linder KM, Cardozo TJ, Bond JC, Boran AD, Iyengar R, Malovannaya A, Lanz RB, Ma'ayan A. Recovering protein-protein and domain-domain interactions from aggregation of IP-MS proteomics of coregulator complexes. Plos Computational Biology. 7: e1002319. PMID 22219718 DOI: 10.1371/Journal.Pcbi.1002319 |
0.769 |
|
| 2011 |
Rangamani P, Fardin MA, Xiong Y, Lipshtat A, Rossier O, Sheetz MP, Iyengar R. Signaling network triggers and membrane physical properties control the actin cytoskeleton-driven isotropic phase of cell spreading. Biophysical Journal. 100: 845-57. PMID 21320428 DOI: 10.1016/J.Bpj.2010.12.3732 |
0.743 |
|
| 2011 |
Michailidis IE, Rusinova R, Georgakopoulos A, Chen Y, Iyengar R, Robakis NK, Logothetis DE, Baki L. Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation. Pflã¼Gers Archiv : European Journal of Physiology. 461: 387-97. PMID 21107857 DOI: 10.1007/S00424-010-0904-3 |
0.325 |
|
| 2011 |
Berger SI, Iyengar R. Role of systems pharmacology in understanding drug adverse events. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 3: 129-35. PMID 20803507 DOI: 10.1002/Wsbm.114 |
0.631 |
|
| 2011 |
Rangamani P, Fardin M, Xiong Y, Lipshtat A, Rossier O, Sheetz M, Iyengar R. Membrane Feedback Controls Signaling Regulation of Cell Spreading Biophysical Journal. 100: 442a. DOI: 10.1016/J.Bpj.2010.12.2605 |
0.745 |
|
| 2011 |
Weng G, Chen Y, Iyengar R. Mammalian Gs‐Stimulated Adenylyl Cyclases Comprehensive Physiology. DOI: 10.1002/Cphy.Cp070108 |
0.325 |
|
| 2010 |
Fardin MA, Rossier OM, Rangamani P, Avigan PD, Gauthier NC, Vonnegut W, Mathur A, Hone J, Iyengar R, Sheetz MP. Cell spreading as a hydrodynamic process. Soft Matter. 6: 4788-4799. PMID 23908673 DOI: 10.1039/C0Sm00252F |
0.581 |
|
| 2010 |
Xiong Y, Rangamani P, Fardin MA, Lipshtat A, Dubin-Thaler B, Rossier O, Sheetz MP, Iyengar R. Mechanisms controlling cell size and shape during isotropic cell spreading. Biophysical Journal. 98: 2136-46. PMID 20483321 DOI: 10.1016/J.Bpj.2010.01.059 |
0.718 |
|
| 2010 |
Berger SI, Ma'ayan A, Iyengar R. Systems pharmacology of arrhythmias. Science Signaling. 3: ra30. PMID 20407125 DOI: 10.1126/Scisignal.2000723 |
0.713 |
|
| 2010 |
Zorina Y, Iyengar R, Bromberg KD. Cannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowth. The Journal of Biological Chemistry. 285: 1358-70. PMID 19861414 DOI: 10.1074/Jbc.M109.049841 |
0.802 |
|
| 2010 |
Berger SI, Iyengar R, Van Hook AM. Science Signaling podcast: 20 April 2010 Science Signaling. 3: pc8. DOI: 10.1126/Scisignal.3118Pc8 |
0.618 |
|
| 2010 |
Zorina Y, Iyengar R, Bromberg KD. Effectors of gαo Handbook of Cell Signaling, 2/E. 2: 1655-1663. DOI: 10.1016/B978-0-12-374145-5.00203-5 |
0.748 |
|
| 2009 |
Cordeddu V, Di Schiavi E, Pennacchio LA, Ma'ayan A, Sarkozy A, Fodale V, Cecchetti S, Cardinale A, Martin J, Schackwitz W, Lipzen A, Zampino G, Mazzanti L, Digilio MC, Martinelli S, ... ... Iyengar R, et al. Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair. Nature Genetics. 41: 1022-6. PMID 19684605 DOI: 10.1038/Ng.425 |
0.553 |
|
| 2009 |
Berger SI, Iyengar R. Network analyses in systems pharmacology. Bioinformatics (Oxford, England). 25: 2466-72. PMID 19648136 DOI: 10.1093/Bioinformatics/Btp465 |
0.641 |
|
| 2009 |
Abul-Husn NS, Bushlin I, Morón JA, Jenkins SL, Dolios G, Wang R, Iyengar R, Ma'ayan A, Devi LA. Systems approach to explore components and interactions in the presynapse. Proteomics. 9: 3303-15. PMID 19562802 DOI: 10.1002/Pmic.200800767 |
0.551 |
|
| 2009 |
Wist AD, Berger SI, Iyengar R. Systems pharmacology and genome medicine: a future perspective. Genome Medicine. 1: 11. PMID 19348698 DOI: 10.1186/Gm11 |
0.637 |
|
| 2009 |
Lipshtat A, Neves SR, Iyengar R. Specification of spatial relationships in directed graphs of cell signaling networks. Annals of the New York Academy of Sciences. 1158: 44-56. PMID 19348631 DOI: 10.1111/J.1749-6632.2008.03748.X |
0.724 |
|
| 2009 |
Ma'ayan A, Jenkins SL, Barash A, Iyengar R. Neuro2A differentiation by Galphai/o pathway. Science Signaling. 2: cm1. PMID 19155528 DOI: 10.1126/Scisignal.254Cm1 |
0.589 |
|
| 2009 |
Ma'ayan A, Jenkins SL, Webb RL, Berger SI, Purushothaman SP, Abul-Husn NS, Posner JM, Flores T, Iyengar R. SNAVI: Desktop application for analysis and visualization of large-scale signaling networks. Bmc Systems Biology. 3: 10. PMID 19154595 DOI: 10.1186/1752-0509-3-10 |
0.73 |
|
| 2009 |
Neves SR, Iyengar R. Models of spatially restricted biochemical reaction systems. The Journal of Biological Chemistry. 284: 5445-9. PMID 18940805 DOI: 10.1074/Jbc.R800058200 |
0.726 |
|
| 2009 |
Iyengar R. Computational biochemistry: systems biology minireview series. The Journal of Biological Chemistry. 284: 5425-6. PMID 18940804 DOI: 10.1074/jbc.R800066200 |
0.368 |
|
| 2009 |
Iyengar R. Information is critical for cellular life Biophysical Journal. 96: 15a. DOI: 10.1016/J.BPJ.2008.12.976 |
0.345 |
|
| 2008 |
Ma'ayan A, Cecchi GA, Wagner J, Rao AR, Iyengar R, Stolovitzky G. Ordered cyclic motifs contribute to dynamic stability in biological and engineered networks. Proceedings of the National Academy of Sciences of the United States of America. 105: 19235-40. PMID 19033453 DOI: 10.1073/Pnas.0805344105 |
0.537 |
|
| 2008 |
Rangamani P, Iyengar R. Modelling cellular signalling systems. Essays in Biochemistry. 45: 83-94. PMID 18793125 DOI: 10.1042/Bse0450083 |
0.608 |
|
| 2008 |
Lu TC, Wang Z, Feng X, Chuang P, Fang W, Chen Y, Neves S, Maayan A, Xiong H, Liu Y, Iyengar R, Klotman PE, He JC. Retinoic acid utilizes CREB and USF1 in a transcriptional feed-forward loop in order to stimulate MKP1 expression in human immunodeficiency virus-infected podocytes. Molecular and Cellular Biology. 28: 5785-94. PMID 18625721 DOI: 10.1128/Mcb.00245-08 |
0.715 |
|
| 2008 |
Ma'ayan A, Lipshtat A, Iyengar R, Sontag ED. Proximity of intracellular regulatory networks to monotone systems. Iet Systems Biology. 2: 103-12. PMID 18537452 DOI: 10.1049/Iet-Syb:20070036 |
0.539 |
|
| 2008 |
Bromberg KD, Iyengar R, He JC. Regulation of neurite outgrowth by G(i/o) signaling pathways. Frontiers in Bioscience : a Journal and Virtual Library. 13: 4544-57. PMID 18508528 DOI: 10.2741/3022 |
0.334 |
|
| 2008 |
Bromberg KD, Ma'ayan A, Neves SR, Iyengar R. Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth. Science (New York, N.Y.). 320: 903-9. PMID 18487186 DOI: 10.1126/Science.1152662 |
0.777 |
|
| 2008 |
Neves SR, Tsokas P, Sarkar A, Grace EA, Rangamani P, Taubenfeld SM, Alberini CM, Schaff JC, Blitzer RD, Moraru II, Iyengar R. Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks. Cell. 133: 666-80. PMID 18485874 DOI: 10.1016/J.Cell.2008.04.025 |
0.798 |
|
| 2008 |
Pagano M, Jordan JD, Neves SR, Nguyen T, Iyengar R. Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways. Cellular Signalling. 20: 1190-7. PMID 18407463 DOI: 10.1016/J.Cellsig.2008.02.008 |
0.768 |
|
| 2008 |
Iyengar R. Teaching resource. Quantitative models of mammalian cell signaling pathways. Science Signaling. 1: tr1. PMID 18290302 DOI: 10.1126/stke.17tr1 |
0.326 |
|
| 2008 |
Lu TC, He JC, Wang ZH, Feng X, Fukumi-Tominaga T, Chen N, Xu J, Iyengar R, Klotman PE. HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting protein. The Journal of Biological Chemistry. 283: 8173-82. PMID 18234668 DOI: 10.1074/Jbc.M708920200 |
0.324 |
|
| 2008 |
Lipshtat A, Purushothaman SP, Iyengar R, Ma'ayan A. Functions of bifans in context of multiple regulatory motifs in signaling networks. Biophysical Journal. 94: 2566-79. PMID 18178648 DOI: 10.1529/biophysj.107.116673 |
0.592 |
|
| 2007 |
Berger SI, Iyengar R, Ma'ayan A. AVIS: AJAX viewer of interactive signaling networks. Bioinformatics (Oxford, England). 23: 2803-5. PMID 17855420 DOI: 10.1093/Bioinformatics/Btm444 |
0.728 |
|
| 2007 |
Zaidel-Bar R, Itzkovitz S, Ma'ayan A, Iyengar R, Geiger B. Functional atlas of the integrin adhesome. Nature Cell Biology. 9: 858-67. PMID 17671451 DOI: 10.1038/Ncb0807-858 |
0.569 |
|
| 2007 |
Tsokas P, Ma T, Iyengar R, Landau EM, Blitzer RD. Mitogen-activated protein kinase upregulates the dendritic translation machinery in long-term potentiation by controlling the mammalian target of rapamycin pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 5885-94. PMID 17537959 DOI: 10.1523/Jneurosci.4548-06.2007 |
0.676 |
|
| 2007 |
Ma'ayan A, Jenkins SL, Goldfarb J, Iyengar R. Network analysis of FDA approved drugs and their targets. The Mount Sinai Journal of Medicine, New York. 74: 27-32. PMID 17516560 DOI: 10.1002/Msj.20002 |
0.527 |
|
| 2007 |
Rangamani P, Iyengar R. Modelling spatio-temporal interactions within the cell. Journal of Biosciences. 32: 157-67. PMID 17426388 DOI: 10.1007/S12038-007-0014-3 |
0.595 |
|
| 2007 |
Aaronson DS, Muller M, Neves SR, Chung WC, Jayaram G, Iyengar R, Ram PT. An androgen-IL-6-Stat3 autocrine loop re-routes EGF signal in prostate cancer cells. Molecular and Cellular Endocrinology. 270: 50-6. PMID 17374439 DOI: 10.1016/J.Mce.2007.02.006 |
0.739 |
|
| 2007 |
He JC, Lu TC, Fleet M, Sunamoto M, Husain M, Fang W, Neves S, Chen Y, Shankland S, Iyengar R, Klotman PE. Retinoic acid inhibits HIV-1-induced podocyte proliferation through the cAMP pathway. Journal of the American Society of Nephrology : Jasn. 18: 93-102. PMID 17182884 DOI: 10.1681/Asn.2006070727 |
0.694 |
|
| 2007 |
Eungdamrong NJ, Iyengar R. Compartment-specific feedback loop and regulated trafficking can result in sustained activation of Ras at the Golgi. Biophysical Journal. 92: 808-15. PMID 17098795 DOI: 10.1529/biophysj.106.093104 |
0.309 |
|
| 2007 |
Xiong YP, Rangamani P, Dubin-Thaler B, Sheetz M, Iyengar R. A three-dimensional stochastic spatio-temporal model of cell spreading Nature Precedings. 2: 1-1. DOI: 10.1038/Npre.2007.62.2 |
0.575 |
|
| 2007 |
Ma'ayan A, Iyengar R, Sontag ED. Intracellular Regulatory Networks are close to Monotone Systems Nature Precedings. 2: 1-1. DOI: 10.1038/Npre.2007.25.1 |
0.541 |
|
| 2007 |
Iyengar R. Dynamic Topology of Biological Networks Nature Precedings. 2: 1-1. DOI: 10.1038/Npre.2007.24.1 |
0.368 |
|
| 2006 |
He JC, Neves SR, Jordan JD, Iyengar R. Role of the Go/i signaling network in the regulation of neurite outgrowth. Canadian Journal of Physiology and Pharmacology. 84: 687-94. PMID 16998532 DOI: 10.1139/y06-025 |
0.731 |
|
| 2006 |
Ma'ayan A, Lipshtat A, Iyengar R. Topology of resultant networks shaped by evolutionary pressure. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. 73: 061912. PMID 16906869 DOI: 10.1103/PhysRevE.73.061912 |
0.544 |
|
| 2006 |
Ma'ayan A, Gardiner K, Iyengar R. The cognitive phenotype of Down syndrome: insights from intracellular network analysis. Neurorx : the Journal of the American Society For Experimental Neurotherapeutics. 3: 396-406. PMID 16815222 DOI: 10.1016/J.Nurx.2006.05.036 |
0.552 |
|
| 2006 |
Ma'ayan A, Iyengar R. From components to regulatory motifs in signalling networks. Briefings in Functional Genomics & Proteomics. 5: 57-61. PMID 16769680 DOI: 10.1093/Bfgp/Ell004 |
0.578 |
|
| 2005 |
Ma'ayan A, Jenkins SL, Neves S, Hasseldine A, Grace E, Dubin-Thaler B, Eungdamrong NJ, Weng G, Ram PT, Rice JJ, Kershenbaum A, Stolovitzky GA, Blitzer RD, Iyengar R. Formation of regulatory patterns during signal propagation in a Mammalian cellular network. Science (New York, N.Y.). 309: 1078-83. PMID 16099987 DOI: 10.1126/Science.1108876 |
0.79 |
|
| 2005 |
He JC, Gomes I, Nguyen T, Jayaram G, Ram PT, Devi LA, Iyengar R. The G alpha(o/i)-coupled cannabinoid receptor-mediated neurite outgrowth involves Rap regulation of Src and Stat3. The Journal of Biological Chemistry. 280: 33426-34. PMID 16046413 DOI: 10.1074/Jbc.M502812200 |
0.59 |
|
| 2005 |
Tsokas P, Grace EA, Chan P, Ma T, Sealfon SC, Iyengar R, Landau EM, Blitzer RD. Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5833-43. PMID 15958750 DOI: 10.1523/Jneurosci.0599-05.2005 |
0.655 |
|
| 2005 |
Ma'ayan A, Blitzer RD, Iyengar R. Toward predictive models of mammalian cells. Annual Review of Biophysics and Biomolecular Structure. 34: 319-49. PMID 15869393 DOI: 10.1146/Annurev.Biophys.34.040204.144415 |
0.733 |
|
| 2005 |
Iyengar R. Teaching resources. Structure of G-protein-coupled receptors and G proteins. Science's Stke : Signal Transduction Knowledge Environment. 2005: tr10. PMID 15784881 DOI: 10.1126/stke.2762005tr10 |
0.31 |
|
| 2005 |
Iyengar R. Teaching resources. Introduction: Overview of pathways and networks and GPCR signaling. Science's Stke : Signal Transduction Knowledge Environment. 2005: tr4. PMID 15701895 DOI: 10.1126/stke.2702005tr4 |
0.363 |
|
| 2005 |
Iyengar R, Diverse-Pierluissi M, Weinstein D, Devi LA. Teaching resources. Cell signaling systems: a course for graduate students. Science's Stke : Signal Transduction Knowledge Environment. 2005: tr3. PMID 15687508 DOI: 10.1126/Stke.2692005Tr3 |
0.309 |
|
| 2005 |
Jordan JD, He JC, Eungdamrong NJ, Gomes I, Ali W, Nguyen T, Bivona TG, Philips MR, Devi LA, Iyengar R. Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII. The Journal of Biological Chemistry. 280: 11413-21. PMID 15657046 DOI: 10.1074/Jbc.M411521200 |
0.517 |
|
| 2005 |
Blitzer RD, Iyengar R, Landau EM. Postsynaptic signaling networks: cellular cogwheels underlying long-term plasticity. Biological Psychiatry. 57: 113-9. PMID 15652868 DOI: 10.1016/J.Biopsych.2004.02.031 |
0.639 |
|
| 2004 |
Eungdamrong NJ, Iyengar R. Computational approaches for modeling regulatory cellular networks. Trends in Cell Biology. 14: 661-9. PMID 15564042 DOI: 10.1016/j.tcb.2004.10.007 |
0.336 |
|
| 2004 |
He JC, Husain M, Sunamoto M, D'Agati VD, Klotman ME, Iyengar R, Klotman PE. Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways. The Journal of Clinical Investigation. 114: 643-51. PMID 15343382 DOI: 10.1172/Jci21004 |
0.317 |
|
| 2004 |
Campagne F, Neves S, Chang CW, Skrabanek L, Ram PT, Iyengar R, Weinstein H. Quantitative information management for the biochemical computation of cellular networks. Science's Stke : Signal Transduction Knowledge Environment. 2004: pl11. PMID 15340175 DOI: 10.1126/Stke.2482004Pl11 |
0.694 |
|
| 2004 |
Eungdamrong NJ, Iyengar R. Modeling cell signaling networks. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 96: 355-62. PMID 15207904 DOI: 10.1016/j.biolcel.2004.03.004 |
0.374 |
|
| 2003 |
Buck E, Iyengar R. Organization and functions of interacting domains for signaling by protein-protein interactions. Science's Stke : Signal Transduction Knowledge Environment. 2003: re14. PMID 14625370 DOI: 10.1126/Stke.2092003Re14 |
0.709 |
|
| 2002 |
Neves SR, Iyengar R. Modeling of signaling networks. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 24: 1110-7. PMID 12447976 DOI: 10.1002/Bies.1154 |
0.715 |
|
| 2002 |
Obrink B, Sawa H, Scheffrahn I, Singer BB, Sigmundsson K, Sundberg U, Heymann R, Beauchemin N, Weng G, Ram P, Iyengar R. Computational analysis of isoform-specific signal regulation by CEACAM1-A cell adhesion molecule expressed in PC12 cells. Annals of the New York Academy of Sciences. 971: 597-607. PMID 12438192 DOI: 10.1111/J.1749-6632.2002.Tb04536.X |
0.38 |
|
| 2002 |
Buck E, Schatz P, Scarlata S, Iyengar R. Role of dynamic interactions in effective signal transfer for Gbeta stimulation of phospholipase C-beta 2. The Journal of Biological Chemistry. 277: 49707-15. PMID 12388553 DOI: 10.1074/Jbc.M205553200 |
0.707 |
|
| 2002 |
Li G, Iyengar R. Calpain as an effector of the Gq signaling pathway for inhibition of Wnt/beta -catenin-regulated cell proliferation. Proceedings of the National Academy of Sciences of the United States of America. 99: 13254-9. PMID 12239346 DOI: 10.1073/Pnas.202355799 |
0.53 |
|
| 2002 |
Bhalla US, Ram PT, Iyengar R. MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science (New York, N.Y.). 297: 1018-23. PMID 12169734 DOI: 10.1126/science.1068873 |
0.653 |
|
| 2002 |
Neves SR, Ram PT, Iyengar R. G protein pathways. Science (New York, N.Y.). 296: 1636-9. PMID 12040175 DOI: 10.1126/Science.1071550 |
0.738 |
|
| 2002 |
Santore TA, Chen Y, Smit MJ, Iyengar R. Adenovirus-directed expression of Q227L-G alpha(s) inhibits growth of established tumors of later-stage human breast cancer cells in athymic mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 1671-6. PMID 11805301 DOI: 10.1073/Pnas.032661999 |
0.781 |
|
| 2002 |
Buck E, Iyengar R. Use of peptide probes to determine function of interaction sites in G protein interactions with effectors. Methods in Enzymology. 344: 513-21. PMID 11771407 DOI: 10.1016/S0076-6879(02)44737-4 |
0.681 |
|
| 2002 |
Santore TA, Iyengar R. Construction of replication defective adenovirus that expresses mutant G alpha s Q227L. Methods in Enzymology. 344: 328-43. PMID 11771394 DOI: 10.1016/S0076-6879(02)44725-8 |
0.757 |
|
| 2002 |
Jordan JD, Iyengar R. Identification of putative direct effectors for G alpha o, using yeast two-hybrid method. Methods in Enzymology. 345: 140-9. PMID 11665601 DOI: 10.1016/S0076-6879(02)45013-6 |
0.355 |
|
| 2001 |
Bhalla US, Iyengar R. Robustness of the bistable behavior of a biological signaling feedback loop. Chaos (Woodbury, N.Y.). 11: 221-226. PMID 12779455 DOI: 10.1063/1.1350440 |
0.636 |
|
| 2001 |
Giovannini MG, Blitzer RD, Wong T, Asoma K, Tsokas P, Morrison JH, Iyengar R, Landau EM. Mitogen-activated protein kinase regulates early phosphorylation and delayed expression of Ca2+/calmodulin-dependent protein kinase II in long-term potentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 7053-62. PMID 11549715 DOI: 10.1523/Jneurosci.21-18-07053.2001 |
0.668 |
|
| 2001 |
Bhalla US, Iyengar R. Functional modules in biological signalling networks. Novartis Foundation Symposium. 239: 4-13; discussion 13-. PMID 11529315 DOI: 10.1002/0470846674.Ch2 |
0.65 |
|
| 2001 |
Buck E, Iyengar R. Modular design of Gbeta as the basis for reversible specificity in effector stimulation. The Journal of Biological Chemistry. 276: 36014-9. PMID 11457830 DOI: 10.1074/Jbc.M103228200 |
0.704 |
|
| 2001 |
Ram PT, Iyengar R. G protein coupled receptor signaling through the Src and Stat3 pathway: role in proliferation and transformation. Oncogene. 20: 1601-6. PMID 11313907 DOI: 10.1038/sj.onc.1204186 |
0.391 |
|
| 2001 |
Holness W, Santore TA, Brown GP, Fallon JT, Taubman MB, Iyengar R. Expression of Q227L-Galpha(s) inhibits intimal vessel wall hyperplasia after balloon injury. Proceedings of the National Academy of Sciences of the United States of America. 98: 1288-93. PMID 11158632 DOI: 10.1073/Pnas.98.3.1288 |
0.767 |
|
| 2000 |
Jordan JD, Landau EM, Iyengar R. Signaling networks: the origins of cellular multitasking. Cell. 103: 193-200. PMID 11057893 DOI: 10.1016/S0092-8674(00)00112-4 |
0.393 |
|
| 2000 |
Brown GP, Blitzer RD, Connor JH, Wong T, Shenolikar S, Iyengar R, Landau EM. Long-term potentiation induced by theta frequency stimulation is regulated by a protein phosphatase-1-operated gate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 7880-7. PMID 11050107 |
0.63 |
|
| 2000 |
Ram PT, Horvath CM, Iyengar R. Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Galphao protein. Science (New York, N.Y.). 287: 142-4. PMID 10615050 DOI: 10.1126/Science.287.5450.142 |
0.36 |
|
| 2000 |
Brown GP, Blitzer RD, Connor JH, Wong T, Shenolikar S, Iyengar R, Landau EM. Long-Term Potentiation Induced by θ Frequency Stimulation Is Regulated by a Protein Phosphatase-1-Operated Gate The Journal of Neuroscience. 20: 7880-7887. DOI: 10.1523/Jneurosci.20-21-07880.2000 |
0.659 |
|
| 1999 |
Weng G, Bhalla US, Iyengar R. Complexity in biological signaling systems. Science (New York, N.Y.). 284: 92-6. PMID 10102825 DOI: 10.1126/science.284.5411.92 |
0.623 |
|
| 1999 |
Buck E, Li J, Chen Y, Weng G, Scarlata S, Iyengar R. Resolution of a signal transfer region from a general binding domain in gbeta for stimulation of phospholipase C-beta2. Science (New York, N.Y.). 283: 1332-5. PMID 10037604 DOI: 10.1126/Science.283.5406.1332 |
0.711 |
|
| 1999 |
Bhalla US, Iyengar R. Emergent properties of networks of biological signaling pathways. Science (New York, N.Y.). 283: 381-7. PMID 9888852 DOI: 10.1126/science.283.5400.381 |
0.648 |
|
| 1998 |
Jordan JD, Iyengar R. Modes of interactions between signaling pathways. Biochemical Pharmacology. 55: 1347-52. PMID 10076524 DOI: 10.1016/S0006-2952(97)00620-5 |
0.376 |
|
| 1998 |
Smit MJ, Verzijl D, Iyengar R. Identity of adenylyl cyclase isoform determines the rate of cell cycle progression in NIH 3T3 cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 15084-9. PMID 9844019 DOI: 10.1073/Pnas.95.25.15084 |
0.38 |
|
| 1998 |
Blitzer RD, Connor JH, Brown GP, Wong T, Shenolikar S, Iyengar R, Landau EM. Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP. Science (New York, N.Y.). 280: 1940-2. PMID 9632393 DOI: 10.1126/Science.280.5371.1940 |
0.667 |
|
| 1998 |
Ford CE, Skiba NP, Bae H, Daaka Y, Reuveny E, Shekter LR, Rosal R, Weng G, Yang CS, Iyengar R, Miller RJ, Jan LY, Lefkowitz RJ, Hamm HE. Molecular basis for interactions of G protein betagamma subunits with effectors. Science (New York, N.Y.). 280: 1271-4. PMID 9596582 DOI: 10.1126/Science.280.5367.1271 |
0.508 |
|
| 1998 |
Chen J, Bander JA, Santore TA, Chen Y, Ram PT, Smit MJ, Iyengar R. Expression of Q227L-galphas in MCF-7 human breast cancer cells inhibits tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 95: 2648-52. PMID 9482941 DOI: 10.1073/Pnas.95.5.2648 |
0.791 |
|
| 1997 |
Chen Y, Harry A, Li J, Smit MJ, Bai X, Magnusson R, Pieroni JP, Weng G, Iyengar R. Adenylyl cyclase 6 is selectively regulated by protein kinase A phosphorylation in a region involved in Galphas stimulation. Proceedings of the National Academy of Sciences of the United States of America. 94: 14100-4. PMID 9391159 DOI: 10.1073/Pnas.94.25.14100 |
0.331 |
|
| 1997 |
Chen Y, Weng G, Li J, Harry A, Pieroni J, Dingus J, Hildebrandt JD, Guarnieri F, Weinstein H, Iyengar R. A surface on the G protein beta-subunit involved in interactions with adenylyl cyclases. Proceedings of the National Academy of Sciences of the United States of America. 94: 2711-4. PMID 9122261 DOI: 10.1073/Pnas.94.6.2711 |
0.307 |
|
| 1997 |
Iyengar R. There are GAPS and there are GAPS. Science (New York, N.Y.). 275: 42-3. PMID 8999536 DOI: 10.1126/science.275.5296.42 |
0.329 |
|
| 1996 |
Iyengar R. Gating by cyclic AMP: expanded role for an old signaling pathway. Science (New York, N.Y.). 271: 461-3. PMID 8560257 DOI: 10.1126/science.271.5248.461 |
0.331 |
|
| 1995 |
Blitzer RD, Wong T, Nouranifar R, Iyengar R, Landau EM. Postsynaptic cAMP pathway gates early LTP in hippocampal CA1 region. Neuron. 15: 1403-14. PMID 8845163 DOI: 10.1016/0896-6273(95)90018-7 |
0.644 |
|
| 1995 |
Mons N, Harry A, Dubourg P, Premont RT, Iyengar R, Cooper DM. Immunohistochemical localization of adenylyl cyclase in rat brain indicates a highly selective concentration at synapses. Proceedings of the National Academy of Sciences of the United States of America. 92: 8473-7. PMID 7667314 DOI: 10.1073/Pnas.92.18.8473 |
0.527 |
|
| 1994 |
Chen J, Iyengar R. Suppression of Ras-induced transformation of NIH 3T3 cells by activated G alpha s. Science (New York, N.Y.). 263: 1278-81. PMID 8122111 DOI: 10.1126/Science.8122111 |
0.352 |
|
| 1994 |
Jacobowitz O, Iyengar R. Phorbol ester-induced stimulation and phosphorylation of adenylyl cyclase 2. Proceedings of the National Academy of Sciences of the United States of America. 91: 10630-4. PMID 7938004 DOI: 10.1073/pnas.91.22.10630 |
0.361 |
|
| 1994 |
Chen J, Carty DJ, Iyengar R. Adenylyl cyclase assay for beta gamma subunits of G proteins. Methods in Enzymology. 237: 451-6. PMID 7935019 DOI: 10.1016/S0076-6879(94)37082-6 |
0.341 |
|
| 1994 |
Ma HW, Iyengar R, Premont RT. Amplification of phosphatidylinositol-specific phospholipase C-beta isoforms using degenerate primers. Methods in Enzymology. 238: 244-52. PMID 7799790 DOI: 10.1016/0076-6879(94)38022-8 |
0.52 |
|
| 1994 |
Landau E, Wong T, Nouranifar R, Iyengar R, Blitzer R. Post-synaptic camp-dependent protein kinase participates in longterm potentiation Biological Psychiatry. 35: 733. DOI: 10.1016/0006-3223(94)91082-0 |
0.64 |
|
| 1993 |
Pieroni JP, Miller D, Premont RT, Iyengar R. Type 5 adenylyl cyclase distribution. Nature. 363: 679-80. PMID 8515810 DOI: 10.1038/363679A0 |
0.445 |
|
| 1993 |
Jacobowitz O, Chen J, Premont RT, Iyengar R. Stimulation of specific types of Gs-stimulated adenylyl cyclases by phorbol ester treatment. The Journal of Biological Chemistry. 268: 3829-32. PMID 8440678 |
0.531 |
|
| 1993 |
Ma HW, Blitzer RD, Healy EC, Premont RT, Landau EM, Iyengar R. Receptor-evoked Cl- current in Xenopus oocytes is mediated through a beta-type phospholipase C. Cloning of a new form of the enzyme. The Journal of Biological Chemistry. 268: 19915-8. PMID 8397190 |
0.701 |
|
| 1993 |
Iyengar R. Molecular and functional diversity of mammalian Gs-stimulated adenylyl cyclases. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 7: 768-75. PMID 8330684 DOI: 10.1096/Fasebj.7.9.8330684 |
0.407 |
|
| 1992 |
Kroll SD, Chen J, De Vivo M, Carty DJ, Buku A, Premont RT, Iyengar R. The Q205LGo-alpha subunit expressed in NIH-3T3 cells induces transformation. The Journal of Biological Chemistry. 267: 23183-8. PMID 1429665 |
0.509 |
|
| 1992 |
Premont RT, Chen J, Ma HW, Ponnapalli M, Iyengar R. Two members of a widely expressed subfamily of hormone-stimulated adenylyl cyclases. Proceedings of the National Academy of Sciences of the United States of America. 89: 9809-13. PMID 1409703 DOI: 10.1073/Pnas.89.20.9809 |
0.58 |
|
| 1992 |
Premont RT, Jacobowitz O, Iyengar R. Lowered responsiveness of the catalyst of adenylyl cyclase to stimulation by GS in heterologous desensitization: a role for adenosine 3',5'-monophosphate-dependent phosphorylation. Endocrinology. 131: 2774-84. PMID 1332848 DOI: 10.1210/Endo.131.6.1332848 |
0.593 |
|
| 1991 |
Carty DJ, Premont RT, Iyengar R. Quantitative immunoblotting of G-protein subunits. Methods in Enzymology. 195: 302-15. PMID 1903493 DOI: 10.1016/0076-6879(91)95175-J |
0.548 |
|
| 1991 |
Codina J, Carty DJ, Birnbaumer L, Iyengar R. Purification of G proteins. Methods in Enzymology. 195: 177-88. PMID 1851927 DOI: 10.1016/0076-6879(91)95164-F |
0.454 |
|
| 1991 |
Kroll SD, Omri G, Landau EM, Iyengar R. Activated alpha subunit of Go protein induces oocyte maturation. Proceedings of the National Academy of Sciences of the United States of America. 88: 5182-6. PMID 1828893 DOI: 10.1073/Pnas.88.12.5182 |
0.312 |
|
| 1990 |
Iyengar R, Birnbaumer L. Roles of G proteins and G protein subunits in signal transduction. Lymphokine Research. 9: 533-7. PMID 2128642 |
0.444 |
|
| 1990 |
Carty DJ, Padrell E, Codina J, Birnbaumer L, Hildebrandt JD, Iyengar R. Distinct guanine nucleotide binding and release properties of the three Gi proteins. The Journal of Biological Chemistry. 265: 6268-73. PMID 2108158 |
0.398 |
|
| 1989 |
Premont RT, Buku A, Iyengar R. The G alpha z gene product in human erythrocytes. Identification as a 41-kilodalton protein. The Journal of Biological Chemistry. 264: 14960-4. PMID 2504714 |
0.488 |
|
| 1989 |
Premont RT, Iyengar R. Heterologous desensitization of the liver adenylyl cyclase: analysis of the role of G-proteins. Endocrinology. 125: 1151-60. PMID 2503363 DOI: 10.1210/Endo-125-3-1151 |
0.605 |
|
| 1988 |
Yatani A, Mattera R, Codina J, Graf R, Okabe K, Padrell E, Iyengar R, Brown AM, Birnbaumer L. The G protein-gated atrial K+ channel is stimulated by three distinct Gi alpha-subunits. Nature. 336: 680-2. PMID 3143915 DOI: 10.1038/336680a0 |
0.45 |
|
| 1988 |
Premont RT, Iyengar R. Glucagon-induced desensitization of adenylyl cyclase in primary cultures of chick hepatocytes. Evidence for multiple pathways. The Journal of Biological Chemistry. 263: 16087-95. PMID 2846535 |
0.529 |
|
| 1988 |
Iyengar R, Rich KA, Herberg JT, Premont RT, Codina J. Glucagon receptor-mediated activation of Gs is accompanied by subunit dissociation. The Journal of Biological Chemistry. 263: 15348-53. PMID 2844810 |
0.532 |
|
| 1988 |
Moriarty TM, Gillo B, Carty DJ, Premont RT, Landau EM, Iyengar R. Beta gamma subunits of GTP-binding proteins inhibit muscarinic receptor stimulation of phospholipase C. Proceedings of the National Academy of Sciences of the United States of America. 85: 8865-9. PMID 2461557 DOI: 10.1073/Pnas.85.23.8865 |
0.534 |
|
| 1987 |
Padrell E, Herberg JT, Monsatirsky B, Floyd G, Premont RT, Iyengar R. The hepatic glucagon receptor: a comparative study of the regulatory and structural properties. Endocrinology. 120: 2316-25. PMID 3032585 DOI: 10.1210/Endo-120-6-2316 |
0.531 |
|
| 1985 |
Birnbaumer L, Codina J, Mattera R, Cerione RA, Hildebrandt JD, Sunyer T, Rojas FJ, Caron MG, Lefkowitz RJ, Iyengar R. Regulation of hormone receptors and adenylyl cyclases by guanine nucleotide binding N proteins. Recent Progress in Hormone Research. 41: 41-99. PMID 2996090 DOI: 10.1016/B978-0-12-571141-8.50006-8 |
0.595 |
|
| 1983 |
Kirchick HJ, Iyengar R, Birnbaumer L. Human chorionic gonadotropin-induced heterologous desensitization of adenylyl cyclase from highly luteinized rat ovaries: attenuation of regulatory N component activity. Endocrinology. 113: 1638-46. PMID 6313327 DOI: 10.1210/endo-113-5-1638 |
0.484 |
|
| 1983 |
Codina J, Hildebrandt J, Iyengar R, Birnbaumer L, Sekura RD, Manclark CR. Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium. Proceedings of the National Academy of Sciences of the United States of America. 80: 4276-80. PMID 6308612 DOI: 10.1073/Pnas.80.14.4276 |
0.472 |
|
| 1983 |
Rojas FJ, Swartz TL, Iyengar R, Garber AJ, Birnbaumer L. Monoiodoglucagon: synthesis, purification by high pressure liquid chromatography, and characteristics as a receptor probe. Endocrinology. 113: 711-9. PMID 6307649 DOI: 10.1210/endo-113-2-711 |
0.445 |
|
| 1983 |
Briggs MM, Stadel JM, Iyengar R, Lefkowitz RJ. Functional modification of the guanine nucleotide regulatory protein after desensitization of turkey erythrocytes by catecholamines. Archives of Biochemistry and Biophysics. 224: 142-51. PMID 6307146 DOI: 10.1016/0003-9861(83)90198-4 |
0.477 |
|
| 1983 |
Hildebrandt JD, Sekura RD, Codina J, Iyengar R, Manclark CR, Birnbaumer L. Stimulation and inhibition of adenylyl cyclases mediated by distinct regulatory proteins. Nature. 302: 706-9. PMID 6300694 DOI: 10.1038/302706A0 |
0.519 |
|
| 1982 |
Iyengar R, Birnbaumer L. Hormone receptor modulates the regulatory component of adenylyl cyclase by reducing its requirement for Mg2+ and enhancing its extent of activation by guanine nucleotides. Proceedings of the National Academy of Sciences of the United States of America. 79: 5179-83. PMID 6291028 DOI: 10.1073/PNAS.79.17.5179 |
0.466 |
|
| 1982 |
Abramowitz J, Iyengar R, Birnbaumer L. Guanine nucleotide and magnesium ion regulation of the interaction of gonadotropic and beta-adrenergic receptors with their hormones: a comparative study using a single membrane system. Endocrinology. 110: 336-46. PMID 6276131 DOI: 10.1210/endo-110-2-336 |
0.46 |
|
| 1981 |
Iyengar R, Birnbaumer L. Hysteretic activation of adenylyl cyclases. I. Effect of Mg ion on the rate of activation by guanine nucleotides and fluoride. The Journal of Biological Chemistry. 256: 11036-41. PMID 7287749 |
0.347 |
|
| 1981 |
Iyengar R, Bhat MK, Riser ME, Birnbaumer L. Receptor-specific desensitization of the S49 lymphoma cell adenylyl cyclase. Unaltered behavior of the regulatory component. The Journal of Biological Chemistry. 256: 4810-5. PMID 6262304 |
0.405 |
|
| 1980 |
Birnbaumer L, Swartz TL, Abramowitz J, Mintz PW, Iyengar R. Transient and steady state kinetics of the interaction of guanyl nucleotides with the adenylyl cyclase system from rat liver plasma membranes. Interpretation in terms of a simple two-state model. The Journal of Biological Chemistry. 255: 3542-51. PMID 7364755 |
0.382 |
|
| 1980 |
Bhat MK, Iyengar R, Abramowitz J, Bordelon-Riser ME, Birnbaumer L. Naturally soluble component(s) that confer(s) guanine nucleotide and fluoride sensitivity to adenylate cyclase. Proceedings of the National Academy of Sciences of the United States of America. 77: 3836-40. PMID 6933440 DOI: 10.1073/Pnas.77.7.3836 |
0.415 |
|
| 1980 |
Iyengar R, Mintz PW, Swartz TL, Birnbaumer L. Divalent cation-induced desensitization of glucagon-stimulable adenylyl cyclase in rat liver plasma membrane. GTP-dependent stimulation by glucagon. The Journal of Biological Chemistry. 255: 11875-82. PMID 6777386 |
0.368 |
|
| 1980 |
Iyengar R, Abramowitz J, Bordelon-Riser M, Blume AJ, Birnbaumer L. Regulation of hormone-receptor coupling to adenylyl cyclase. Effects of GTP and GDP. The Journal of Biological Chemistry. 255: 10312-21. PMID 6253469 |
0.426 |
|
| 1980 |
Birnbaumer L, Bearer CF, Iyengar R. A two-state model of an enzyme with an allosteric regulatory site capable of metabolizing the regulatory ligand. Simplified mathematical treatments of transient and steady state kinetics of an activator and its competitive inhibition as applied to adenylyl cyclases. The Journal of Biological Chemistry. 255: 3552-7. PMID 6102566 |
0.367 |
|
| 1979 |
Abramowitz J, Iyengar R, Birnbaumer L. Guanyl nucleotide regulation of hormonally-responsive adenylyl cyclases. Molecular and Cellular Endocrinology. 16: 129-46. PMID 230102 DOI: 10.1016/0303-7207(79)90022-4 |
0.474 |
|
| 1979 |
Iyengar R, Birnbaumer L. Coupling of the glucagon receptor to adenylyl cyclase by GDP: evidence for two levels of regulation of adenylyl cyclase. Proceedings of the National Academy of Sciences of the United States of America. 76: 3189-93. PMID 226958 DOI: 10.1073/PNAS.76.7.3189 |
0.515 |
|
| 1979 |
Iyengar R, Swartz TL, Birnbaumer L. Coupling of glucagon receptor to adenylyl cyclase. Requirement of a receptor-related guanyl nucleotide binding site for coupling of receptor to the enzyme. The Journal of Biological Chemistry. 254: 1119-23. PMID 216687 |
0.391 |
|
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