David C. Klein - Publications

Affiliations: 
National Institute of Child Health and Human Development, Bethesda, MD, United States 
Area:
Melatonin Biosynthesis

207 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Carstensen MB, Hertz H, Bering T, Møller M, Rohde K, Klein DC, Coon SL, Rath MF. Circadian regulation and molecular role of the Bsx homeobox gene in the adult pineal gland. Journal of Pineal Research. e12629. PMID 31808568 DOI: 10.1111/jpi.12629  0.399
2019 Hertz H, Carstensen MB, Bering T, Rohde K, Møller M, Granau AM, Coon SL, Klein DC, Rath MF. The Lhx4 homeobox transcript in the rat pineal gland: adrenergic regulation and impact on transcripts encoding melatonin-synthesizing enzymes. Journal of Pineal Research. e12616. PMID 31609018 DOI: 10.1111/jpi.12616  0.405
2018 Mays JC, Kelly MC, Coon SL, Holtzclaw L, Rath MF, Kelley MW, Klein DC. Single-cell RNA sequencing of the mammalian pineal gland identifies two pinealocyte subtypes and cell type-specific daily patterns of gene expression. Plos One. 13: e0205883. PMID 30347410 DOI: 10.1371/Journal.Pone.0205883  0.357
2017 Backlund PS, Urbanski HF, Doll MA, Hein DW, Bozinoski M, Mason CE, Coon SL, Klein DC. Daily Rhythm in Plasma N-acetyltryptamine. Journal of Biological Rhythms. 748730417700458. PMID 28466676 DOI: 10.1177/0748730417700458  0.338
2016 Ben-Moshe Livne Z, Alon S, Vallone D, Bayleyen Y, Tovin A, Shainer I, Nisembaum LG, Aviram I, Smadja-Storz S, Fuentes M, Falcón J, Eisenberg E, Klein DC, Burgess HA, Foulkes NS, et al. Genetically Blocking the Zebrafish Pineal Clock Affects Circadian Behavior. Plos Genetics. 12: e1006445. PMID 27870848 DOI: 10.1371/Journal.Pgen.1006445  0.374
2016 Hartley SW, Mullikin JC, Klein DC, Park M, Coon SL. Alternative Isoform Analysis of Ttc8 Expression in the Rat Pineal Gland Using a Multi-Platform Sequencing Approach Reveals Neural Regulation. Plos One. 11: e0163590. PMID 27684375 DOI: 10.1371/Journal.Pone.0163590  0.311
2016 Rath MF, Coon SL, Amaral FG, Weller JL, Møller M, Klein DC. Melatonin synthesis: Acetylserotonin O-methyltransferase (ASMT) is strongly expressed in a subpopulation of pinealocytes in the male rat pineal gland. Endocrinology. en20151888. PMID 26950199 DOI: 10.1210/en.2015-1888  0.383
2015 Hartley SW, Coon SL, Savastano LE, Mullikin JC, Fu C, Klein DC. Neurotranscriptomics: The Effects of Neonatal Stimulus Deprivation on the Rat Pineal Transcriptome. Plos One. 10: e0137548. PMID 26367423 DOI: 10.1371/Journal.Pone.0137548  0.362
2015 Yamazaki F, Møller M, Fu C, Clokie SJ, Zykovich A, Coon SL, Klein DC, Rath MF. The Lhx9 homeobox gene controls pineal gland development and prevents postnatal hydrocephalus. Brain Structure & Function. 220: 1497-509. PMID 24647753 DOI: 10.1007/s00429-014-0740-x  0.311
2014 Falcón J, Coon SL, Besseau L, Cazaméa-Catalan D, Fuentès M, Magnanou E, Paulin CH, Boeuf G, Sauzet S, Jørgensen EH, Mazan S, Wolf YI, Koonin EV, Steinbach PJ, Hyodo S, ... Klein DC, et al. Drastic neofunctionalization associated with evolution of the timezyme AANAT 500 Mya. Proceedings of the National Academy of Sciences of the United States of America. 111: 314-9. PMID 24351931 DOI: 10.1073/Pnas.1312634110  0.38
2013 Kucka M, Bjelobaba I, Clokie SJ, Klein DC, Stojilkovic SS. Female-specific induction of rat pituitary dentin matrix protein-1 by GnRH. Molecular Endocrinology (Baltimore, Md.). 27: 1840-55. PMID 24085820 DOI: 10.1210/me.2013-1068  0.354
2013 Matsuo M, Coon SL, Klein DC. RGS2 is a feedback inhibitor of melatonin production in the pineal gland. Febs Letters. 587: 1392-8. PMID 23523917 DOI: 10.1016/j.febslet.2013.03.016  0.353
2013 Rath MF, Rohde K, Klein DC, Møller M. Homeobox genes in the rodent pineal gland: roles in development and phenotype maintenance. Neurochemical Research. 38: 1100-12. PMID 23076630 DOI: 10.1007/s11064-012-0906-y  0.331
2012 Tovin A, Alon S, Ben-Moshe Z, Mracek P, Vatine G, Foulkes NS, Jacob-Hirsch J, Rechavi G, Toyama R, Coon SL, Klein DC, Eisenberg E, Gothilf Y. Systematic identification of rhythmic genes reveals camk1gb as a new element in the circadian clockwork. Plos Genetics. 8: e1003116. PMID 23284293 DOI: 10.1371/Journal.Pgen.1003116  0.356
2012 Coon SL, Munson PJ, Cherukuri PF, Sugden D, Rath MF, Møller M, Clokie SJ, Fu C, Olanich ME, Rangel Z, Werner T, Mullikin JC, Klein DC. Circadian changes in long noncoding RNAs in the pineal gland. Proceedings of the National Academy of Sciences of the United States of America. 109: 13319-24. PMID 22864914 DOI: 10.1073/Pnas.1207748109  0.378
2012 Ochocinska MJ, Muñoz EM, Veleri S, Weller JL, Coon SL, Pozdeyev N, Iuvone PM, Goebbels S, Furukawa T, Klein DC. NeuroD1 is required for survival of photoreceptors but not pinealocytes: results from targeted gene deletion studies. Journal of Neurochemistry. 123: 44-59. PMID 22784109 DOI: 10.1111/J.1471-4159.2012.07870.X  0.329
2011 Rovsing L, Clokie S, Bustos DM, Rohde K, Coon SL, Litman T, Rath MF, Møller M, Klein DC. Crx broadly modulates the pineal transcriptome. Journal of Neurochemistry. 119: 262-74. PMID 21797868 DOI: 10.1111/j.1471-4159.2011.07405.x  0.349
2011 Haque R, Chong NW, Ali F, Chaurasia SS, Sengupta T, Chun E, Howell JC, Klein DC, Iuvone PM. Melatonin synthesis in retina: cAMP-dependent transcriptional regulation of chicken arylalkylamine N-acetyltransferase by a CRE-like sequence and a TTATT repeat motif in the proximal promoter. Journal of Neurochemistry. 119: 6-17. PMID 21790603 DOI: 10.1111/J.1471-4159.2011.07397.X  0.34
2011 Rohde K, Klein DC, Møller M, Rath MF. Rax : developmental and daily expression patterns in the rat pineal gland and retina. Journal of Neurochemistry. 118: 999-1007. PMID 21749377 DOI: 10.1111/j.1471-4159.2011.07385.x  0.387
2011 Zilberman-Peled B, Bransburg-Zabary S, Klein DC, Gothilf Y. Molecular evolution of multiple arylalkylamine N-acetyltransferase (AANAT) in fish. Marine Drugs. 9: 906-21. PMID 21673898 DOI: 10.3390/md9050906  0.306
2011 Bustos DM, Bailey MJ, Sugden D, Carter DA, Rath MF, Møller M, Coon SL, Weller JL, Klein DC. Global daily dynamics of the pineal transcriptome. Cell and Tissue Research. 344: 1-11. PMID 21302120 DOI: 10.1007/S00441-010-1094-1  0.374
2010 Pavlicek J, Sauzet S, Besseau L, Coon SL, Weller JL, Boeuf G, Gaildrat P, Omelchenko MV, Koonin EV, Falcón J, Klein DC. Evolution of AANAT: expansion of the gene family in the cephalochordate amphioxus. Bmc Evolutionary Biology. 10: 154. PMID 20500864 DOI: 10.1186/1471-2148-10-154  0.362
2010 Haque R, Ali FG, Biscoglia R, Abey J, Weller J, Klein D, Iuvone PM. CLOCK and NPAS2 have overlapping roles in the circadian oscillation of arylalkylamine N-acetyltransferase mRNA in chicken cone photoreceptors. Journal of Neurochemistry. 113: 1296-306. PMID 20345751 DOI: 10.1111/J.1471-4159.2010.06698.X  0.376
2010 Kim JS, Bailey MJ, Weller JL, Sugden D, Rath MF, Møller M, Klein DC. Thyroid hormone and adrenergic signaling interact to control pineal expression of the dopamine receptor D4 gene (Drd4). Molecular and Cellular Endocrinology. 314: 128-35. PMID 19482058 DOI: 10.1016/j.mce.2009.05.013  0.344
2009 Toyama R, Chen X, Jhawar N, Aamar E, Epstein J, Reany N, Alon S, Gothilf Y, Klein DC, Dawid IB. Transcriptome analysis of the zebrafish pineal gland. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 238: 1813-26. PMID 19504458 DOI: 10.1002/dvdy.21988  0.309
2009 Kim JS, Coon SL, Weller JL, Blackshaw S, Rath MF, Møller M, Klein DC. Muscleblind-like 2: circadian expression in the mammalian pineal gland is controlled by an adrenergic-cAMP mechanism. Journal of Neurochemistry. 110: 756-64. PMID 19457059 DOI: 10.1111/j.1471-4159.2009.06184.x  0.401
2009 Kim SM, Power A, Brown TM, Constance CM, Coon SL, Nishimura T, Hirai H, Cai T, Eisner C, Weaver DR, Piggins HD, Klein DC, Schnermann J, Notkins AL. Deletion of the secretory vesicle proteins IA-2 and IA-2beta disrupts circadian rhythms of cardiovascular and physical activity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 3226-32. PMID 19433624 DOI: 10.1096/Fj.09-132019  0.301
2009 Bailey MJ, Coon SL, Carter DA, Humphries A, Kim JS, Shi Q, Gaildrat P, Morin F, Ganguly S, Hogenesch JB, Weller JL, Rath MF, Møller M, Baler R, Sugden D, ... ... Klein DC, et al. Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling. The Journal of Biological Chemistry. 284: 7606-22. PMID 19103603 DOI: 10.1074/Jbc.M808394200  0.351
2009 Rath MF, Bailey MJ, Kim JS, Coon SL, Klein DC, Møller M. Developmental and daily expression of the Pax4 and Pax6 homeobox genes in the rat retina: localization of Pax4 in photoreceptor cells. Journal of Neurochemistry. 108: 285-94. PMID 19012751 DOI: 10.1111/j.1471-4159.2008.05765.x  0.331
2009 Rath MF, Bailey MJ, Kim JS, Ho AK, Gaildrat P, Coon SL, Møller M, Klein DC. Developmental and diurnal dynamics of Pax4 expression in the mammalian pineal gland: nocturnal down-regulation is mediated by adrenergic-cyclic adenosine 3',5'-monophosphate signaling. Endocrinology. 150: 803-11. PMID 18818287 DOI: 10.1210/en.2008-0882  0.406
2008 Klitten LL, Rath MF, Coon SL, Kim JS, Klein DC, Møller M. Localization and regulation of dopamine receptor D4 expression in the adult and developing rat retina. Experimental Eye Research. 87: 471-7. PMID 18778704 DOI: 10.1016/j.exer.2008.08.004  0.364
2008 Pavlicek J, Coon SL, Ganguly S, Weller JL, Hassan SA, Sackett DL, Klein DC. Evidence that proline focuses movement of the floppy loop of arylalkylamine N-acetyltransferase (EC 2.3.1.87). The Journal of Biological Chemistry. 283: 14552-8. PMID 18362150 DOI: 10.1074/jbc.M800593200  0.326
2007 Ganguly S, Grodzki C, Sugden D, Møller M, Odom S, Gaildrat P, Gery I, Siraganian RP, Rivera J, Klein DC. Neural adrenergic/cyclic AMP regulation of the immunoglobulin E receptor alpha-subunit expression in the mammalian pinealocyte: a neuroendocrine/immune response link? The Journal of Biological Chemistry. 282: 32758-64. PMID 17728245 DOI: 10.1074/Jbc.M705950200  0.355
2007 Muñoz EM, Bailey MJ, Rath MF, Shi Q, Morin F, Coon SL, Møller M, Klein DC. NeuroD1: developmental expression and regulated genes in the rodent pineal gland. Journal of Neurochemistry. 102: 887-99. PMID 17630985 DOI: 10.1111/j.1471-4159.2007.04605.x  0.364
2007 Rath MF, Morin F, Shi Q, Klein DC, Møller M. Ontogenetic expression of the Otx2 and Crx homeobox genes in the retina of the rat. Experimental Eye Research. 85: 65-73. PMID 17467693 DOI: 10.1016/j.exer.2007.02.016  0.304
2007 Humphries A, Wells T, Baler R, Klein DC, Carter DA. Rodent Aanat: intronic E-box sequences control tissue specificity but not rhythmic expression in the pineal gland. Molecular and Cellular Endocrinology. 270: 43-9. PMID 17363136 DOI: 10.1016/J.Mce.2007.02.003  0.341
2007 Hwang Y, Ganguly S, Ho AK, Klein DC, Cole PA. Enzymatic and cellular study of a serotonin N-acetyltransferase phosphopantetheine-based prodrug. Bioorganic & Medicinal Chemistry. 15: 2147-55. PMID 17258461 DOI: 10.1016/J.Bmc.2006.12.016  0.337
2007 Kim JS, Bailey MJ, Ho AK, Møller M, Gaildrat P, Klein DC. Daily rhythm in pineal phosphodiesterase (PDE) activity reflects adrenergic/3',5'-cyclic adenosine 5'-monophosphate induction of the PDE4B2 variant. Endocrinology. 148: 1475-85. PMID 17204557 DOI: 10.1210/en.2006-1420  0.41
2007 Zilberman-Peled B, Appelbaum L, Vallone D, Foulkes NS, Anava S, Anzulovich A, Coon SL, Klein DC, Falcón J, Ron B, Gothilf Y. Transcriptional regulation of arylalkylamine-N-acetyltransferase-2 gene in the pineal gland of the gilthead seabream. Journal of Neuroendocrinology. 19: 46-53. PMID 17184485 DOI: 10.1111/j.1365-2826.2006.01501.x  0.398
2007 Klein DC. Arylalkylamine N-acetyltransferase: "the Timezyme". The Journal of Biological Chemistry. 282: 4233-7. PMID 17164235 DOI: 10.1074/jbc.R600036200  0.366
2006 Pozdeyev N, Taylor C, Haque R, Chaurasia SS, Visser A, Thazyeen A, Du Y, Fu H, Weller J, Klein DC, Iuvone PM. Photic regulation of arylalkylamine N-acetyltransferase binding to 14-3-3 proteins in retinal photoreceptor cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 9153-61. PMID 16957072 DOI: 10.1523/Jneurosci.1384-06.2006  0.362
2006 Klein DC. Evolution of the vertebrate pineal gland: the AANAT hypothesis. Chronobiology International. 23: 5-20. PMID 16687276 DOI: 10.1080/07420520500545839  0.371
2006 Rath MF, Muñoz E, Ganguly S, Morin F, Shi Q, Klein DC, Møller M. Expression of the Otx2 homeobox gene in the developing mammalian brain: embryonic and adult expression in the pineal gland. Journal of Neurochemistry. 97: 556-66. PMID 16539656 DOI: 10.1111/j.1471-4159.2006.03773.x  0.333
2006 Vuilleumier R, Besseau L, Boeuf G, Piparelli A, Gothilf Y, Gehring WG, Klein DC, Falcón J. Starting the zebrafish pineal circadian clock with a single photic transition. Endocrinology. 147: 2273-9. PMID 16497800 DOI: 10.1210/en.2005-1565  0.379
2006 Besseau L, Benyassi A, Møller M, Coon SL, Weller JL, Boeuf G, Klein DC, Falcón J. Melatonin pathway: breaking the 'high-at-night' rule in trout retina. Experimental Eye Research. 82: 620-7. PMID 16289161 DOI: 10.1016/j.exer.2005.08.025  0.37
2005 Iuvone PM, Tosini G, Pozdeyev N, Haque R, Klein DC, Chaurasia SS. Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina. Progress in Retinal and Eye Research. 24: 433-56. PMID 15845344 DOI: 10.1016/j.preteyeres.2005.01.003  0.363
2005 Gaildrat P, Møller M, Mukda S, Humphries A, Carter DA, Ganapathy V, Klein DC. A novel pineal-specific product of the oligopeptide transporter PepT1 gene: circadian expression mediated by cAMP activation of an intronic promoter. The Journal of Biological Chemistry. 280: 16851-60. PMID 15684415 DOI: 10.1074/Jbc.M414587200  0.38
2005 Ganguly S, Weller JL, Ho A, Chemineau P, Malpaux B, Klein DC. Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. Proceedings of the National Academy of Sciences of the United States of America. 102: 1222-7. PMID 15644438 DOI: 10.1073/pnas.0406871102  0.302
2005 Zheng W, Schwarzer D, Lebeau A, Weller JL, Klein DC, Cole PA. Cellular stability of serotonin N-acetyltransferase conferred by phosphonodifluoromethylene alanine (Pfa) substitution for Ser-205. The Journal of Biological Chemistry. 280: 10462-7. PMID 15632116 DOI: 10.1074/Jbc.M412283200  0.355
2005 Kim JS, Coon SL, Blackshaw S, Cepko CL, Møller M, Mukda S, Zhao WQ, Charlton CG, Klein DC. Methionine adenosyltransferase:adrenergic-cAMP mechanism regulates a daily rhythm in pineal expression. The Journal of Biological Chemistry. 280: 677-84. PMID 15504733 DOI: 10.1074/jbc.M408438200  0.387
2004 Price DM, Chik CL, Terriff D, Weller J, Humphries A, Carter DA, Klein DC, Ho AK. Mitogen-activated protein kinase phosphatase-1 (MKP-1): >100-fold nocturnal and norepinephrine-induced changes in the rat pineal gland. Febs Letters. 577: 220-6. PMID 15527789 DOI: 10.1016/J.Febslet.2004.09.083  0.399
2004 Humphries A, Weller J, Klein D, Baler R, Carter DA. NGFI-B (Nurr77/Nr4a1) orphan nuclear receptor in rat pinealocytes: Circadian expression involves an adrenergic-cyclic AMP mechanism Journal of Neurochemistry. 91: 946-955. PMID 15525348 DOI: 10.1111/J.1471-4159.2004.02777.X  0.345
2004 Klein DC. The 2004 Aschoff/Pittendrigh lecture: Theory of the origin of the pineal gland--a tale of conflict and resolution. Journal of Biological Rhythms. 19: 264-79. PMID 15245646 DOI: 10.1177/0748730404267340  0.357
2004 Appelbaum L, Toyama R, Dawid IB, Klein DC, Baler R, Gothilf Y. Zebrafish serotonin-N-acetyltransferase-2 gene regulation: pineal-restrictive downstream module contains a functional E-box and three photoreceptor conserved elements. Molecular Endocrinology (Baltimore, Md.). 18: 1210-21. PMID 14988431 DOI: 10.1210/me.2003-0439  0.325
2003 Zheng W, Zhang Z, Ganguly S, Weller JL, Klein DC, Cole PA. Cellular stabilization of the melatonin rhythm enzyme induced by nonhydrolyzable phosphonate incorporation. Nature Structural Biology. 10: 1054-7. PMID 14578935 DOI: 10.1038/Nsb1005  0.349
2003 Chong NW, Chaurasia SS, Haque R, Klein DC, Iuvone PM. Temporal-spatial characterization of chicken clock genes: circadian expression in retina, pineal gland, and peripheral tissues. Journal of Neurochemistry. 85: 851-60. PMID 12716417 DOI: 10.1046/J.1471-4159.2003.01723.X  0.35
2003 Falcón J, Gothilf Y, Coon SL, Boeuf G, Klein DC. Genetic, temporal and developmental differences between melatonin rhythm generating systems in the teleost fish pineal organ and retina. Journal of Neuroendocrinology. 15: 378-82. PMID 12622837 DOI: 10.1046/j.1365-2826.2003.00993.x  0.374
2002 Gothilf Y, Toyama R, Coon SL, Du SJ, Dawid IB, Klein DC. Pineal-specific expression of green fluorescent protein under the control of the serotonin-N-acetyltransferase gene regulatory regions in transgenic zebrafish. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 225: 241-9. PMID 12412006 DOI: 10.1002/dvdy.10152  0.31
2002 Coon SL, Del Olmo E, Young WS, Klein DC. Melatonin synthesis enzymes in Macaca mulatta: focus on arylalkylamine N-acetyltransferase (EC 2.3.1.87). The Journal of Clinical Endocrinology and Metabolism. 87: 4699-706. PMID 12364461 DOI: 10.1210/jc.2002-020683  0.42
2002 Klein DC, Ganguly S, Coon S, Weller JL, Obsil T, Hickman A, Dyda F. 14-3-3 Proteins and photoneuroendocrine transduction: role in controlling the daily rhythm in melatonin. Biochemical Society Transactions. 30: 365-73. PMID 12196096 DOI: 10.1042/Bst0300365  0.371
2002 Schomerus C, Laedtke E, Olcese J, Weller JL, Klein DC, Korf HW. Signal transduction and regulation of melatonin synthesis in bovine pinealocytes: impact of adrenergic, peptidergic and cholinergic stimuli. Cell and Tissue Research. 309: 417-28. PMID 12195298 DOI: 10.1007/S00441-002-0588-X  0.379
2002 Ganguly S, Coon SL, Klein DC. Control of melatonin synthesis in the mammalian pineal gland: the critical role of serotonin acetylation. Cell and Tissue Research. 309: 127-37. PMID 12111543 DOI: 10.1007/s00441-002-0579-y  0.38
2002 Chik CL, Liu Q, Li B, Klein DC, Zylka M, Kim DS, Chin H, Karpinski E, Ho AK. α1D L-Type Ca2+-Channel Currents: Inhibition by a β-Adrenergic Agonist and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Rat Pinealocytes Journal of Neurochemistry. 68: 1078-1087. DOI: 10.1046/j.1471-4159.1997.68031078.x  0.703
2001 Ganguly S, Mummaneni P, Steinbach PJ, Klein DC, Coon SL. Characterization of the Saccharomyces cerevisiae homolog of the melatonin rhythm enzyme arylalkylamine N-acetyltransferase (EC 2.3.1.87). The Journal of Biological Chemistry. 276: 47239-47. PMID 11559708 DOI: 10.1074/jbc.M107222200  0.33
2001 Ganguly S, Gastel JA, Weller JL, Schwartz C, Jaffe H, Namboodiri MA, Coon SL, Hickman AB, Rollag M, Obsil T, Beauverger P, Ferry G, Boutin JA, Klein DC. Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis. Proceedings of the National Academy of Sciences of the United States of America. 98: 8083-8. PMID 11427721 DOI: 10.1073/Pnas.141118798  0.349
2001 Smith M, Burke Z, Humphries A, Wells T, Klein D, Carter D, Baler R. Tissue-specific transgenic knockdown of Fos-related antigen 2 (Fra-2) expression mediated by dominant negative Fra-2 Molecular and Cellular Biology. 21: 3704-3713. PMID 11340164 DOI: 10.1128/Mcb.21.11.3704-3713.2001  0.34
2001 Obsil T, Ghirlando R, Klein DC, Ganguly S, Dyda F. Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation. Cell. 105: 257-67. PMID 11336675 DOI: 10.1016/S0092-8674(01)00316-6  0.313
2001 Falcón J, Galarneau KM, Weller JL, Ron B, Chen G, Coon SL, Klein DC. Regulation of arylalkylamine N-acetyltransferase-2 (AANAT2, EC 2.3.1.87) in the fish pineal organ: evidence for a role of proteasomal proteolysis. Endocrinology. 142: 1804-13. PMID 11316744 DOI: 10.1210/endo.142.5.8129  0.421
2001 Coon SL, Weller JL, Korf HW, Namboodiri MA, Rollag M, Klein DC. cAmp regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87): a new cell line (1E7) provides evidence of intracellular AANAT activation. The Journal of Biological Chemistry. 276: 24097-107. PMID 11313340 DOI: 10.1074/jbc.M011298200  0.378
2000 Schomerus C, Korf HW, Laedtke E, Weller JL, Klein DC. Selective adrenergic/cyclic AMP-dependent switch-off of proteasomal proteolysis alone switches on neural signal transduction: an example from the pineal gland. Journal of Neurochemistry. 75: 2123-32. PMID 11032902 DOI: 10.1046/j.1471-4159.2000.0752123.x  0.365
2000 Chong NW, Bernard M, Klein DC. Characterization of the chicken serotonin N-acetyltransferase gene. Activation via clock gene heterodimer/E box interaction. The Journal of Biological Chemistry. 275: 32991-8. PMID 10931848 DOI: 10.1074/jbc.M005671200  0.364
2000 Schwartz WJ, Carpino A, de la Iglesia HO, Baler R, Klein DC, Nakabeppu Y, Aronin N. Differential regulation of fos family genes in the ventrolateral and dorsomedial subdivisions of the rat suprachiasmatic nucleus. Neuroscience. 98: 535-47. PMID 10869847 DOI: 10.1016/S0306-4522(00)00140-8  0.359
2000 Zatz M, Gastel JA, Heath JR, Klein DC. Chick pineal melatonin synthesis: light and cyclic AMP control abundance of serotonin N-acetyltransferase protein. Journal of Neurochemistry. 74: 2315-21. PMID 10820191 DOI: 10.1046/j.1471-4159.2000.0742315.x  0.409
2000 Benyassi A, Schwartz C, Coon SL, Klein DC, Falcón J. Melatonin synthesis: arylalkylamine N-acetyltransferases in trout retina and pineal organ are different. Neuroreport. 11: 255-8. PMID 10674465 DOI: 10.1097/00001756-200002070-00006  0.366
1999 Iuvone PM, Chong NW, Bernard M, Brown AD, Thomas KB, Klein DC. Melatonin biosynthesis in chicken retina. Regulation of tryptophan hydroxylase and arylalkylamine N-acetyltransferase. Advances in Experimental Medicine and Biology. 460: 31-41. PMID 10810497 DOI: 10.1007/0-306-46814-X_4  0.355
1999 Baler R, Covington S, Klein DC. Rat arylalkylamine N-acetyltransferase gene: upstream and intronic components of a bipartite promoter. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 91: 699-705. PMID 10668100 DOI: 10.1016/S0248-4900(00)88533-0  0.375
1999 Burke Z, Wells T, Carter D, Klein D, Baler R. Genetic targeting: The serotonin N-acetyltransferase promoter imparts circadian expression selectively in the pineal gland and retina of transgenic rats Journal of Neurochemistry. 73: 1343-1349. PMID 10501177 DOI: 10.1046/J.1471-4159.1999.0731343.X  0.372
1999 Gothilf Y, Coon SL, Toyama R, Chitnis A, Namboodiri MA, Klein DC. Zebrafish serotonin N-acetyltransferase-2: marker for development of pineal photoreceptors and circadian clock function. Endocrinology. 140: 4895-903. PMID 10499549 DOI: 10.1210/Endo.140.10.6975  0.387
1999 Bernard M, Guerlotté J, Grève P, Gréchez-Cassiau A, Iuvone MP, Zatz M, Chong NW, Klein DC, Voisin P. Melatonin synthesis pathway: circadian regulation of the genes encoding the key enzymes in the chicken pineal gland and retina. Reproduction, Nutrition, Development. 39: 325-34. PMID 10420435 DOI: 10.1051/Rnd:19990305  0.395
1999 Coon SL, Bégay V, Deurloo D, Falcón J, Klein DC. Two arylalkylamine N-acetyltransferase genes mediate melatonin synthesis in fish. The Journal of Biological Chemistry. 274: 9076-82. PMID 10085157 DOI: 10.1074/jbc.274.13.9076  0.391
1999 Hickman AB, Klein DC, Dyda F. Melatonin biosynthesis: the structure of serotonin N-acetyltransferase at 2.5 A resolution suggests a catalytic mechanism. Molecular Cell. 3: 23-32. PMID 10024876 DOI: 10.1016/S1097-2765(00)80171-9  0.314
1999 Fleming JV, Barrett P, Coon SL, Klein DC, Morgan PJ. Ovine arylalkylamine N-acetyltransferase in the pineal and pituitary glands: differences in function and regulation. Endocrinology. 140: 972-8. PMID 9927331 DOI: 10.1210/endo.140.2.6496  0.34
1998 Roseboom PH, Namboodiri MA, Zimonjic DB, Popescu NC, Rodriguez IR, Gastel JA, Klein DC. Natural melatonin 'knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase. Brain Research. Molecular Brain Research. 63: 189-97. PMID 9838107 DOI: 10.1016/S0169-328X(98)00273-3  0.301
1998 Coon SL, Bégay V, Falcón J, Klein DC. Expression of melatonin synthesis genes is controlled by a circadian clock in the pike pineal organ but not in the trout. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 90: 399-405. PMID 9835014 DOI: 10.1016/S0248-4900(98)80089-0  0.396
1998 Chong NW, Cassone VM, Bernard M, Klein DC, Iuvone PM. Circadian expression of tryptophan hydroxylase mRNA in the chicken retina. Brain Research. Molecular Brain Research. 61: 243-50. PMID 9795235 DOI: 10.1016/S0169-328X(98)00219-8  0.368
1998 Bégay V, Falcón J, Cahill GM, Klein DC, Coon SL. Transcripts encoding two melatonin synthesis enzymes in the teleost pineal organ: circadian regulation in pike and zebrafish, but not in trout. Endocrinology. 139: 905-12. PMID 9492019 DOI: 10.1210/endo.139.3.5790  0.359
1998 Gastel JA, Roseboom PH, Rinaldi PA, Weller JL, Klein DC. Melatonin production: proteasomal proteolysis in serotonin N-acetyltransferase regulation. Science (New York, N.Y.). 279: 1358-60. PMID 9478897 DOI: 10.1126/science.279.5355.1358  0.387
1998 De Angelis J, Gastel J, Klein DC, Cole PA. Kinetic analysis of the catalytic mechanism of serotonin N-acetyltransferase (EC 2.3.1.87). The Journal of Biological Chemistry. 273: 3045-50. PMID 9446620 DOI: 10.1074/Jbc.273.5.3045  0.327
1997 Iuvone PM, Bernard M, Alonso-Gomez A, Greve P, Cassone VM, Klein DC. Cellular and molecular regulation of serotonin N-acetyltransferase activity in chicken retinal photoreceptors. Biological Signals. 6: 217-24. PMID 9500659 DOI: 10.1159/000109131  0.402
1997 Klein DC, Coon SL, Roseboom PH, Weller JL, Bernard M, Gastel JA, Zatz M, Iuvone PM, Rodriguez IR, Bégay V, Falcón J, Cahill GM, Cassone VM, Baler R. The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland. Recent Progress in Hormone Research. 52: 307-57; discussion 3. PMID 9238858  0.308
1997 Baler R, Covington S, Klein DC. The rat arylalkylamine N-acetyltransferase gene promoter. cAMP activation via a cAMP-responsive element-CCAAT complex. The Journal of Biological Chemistry. 272: 6979-85. PMID 9054387 DOI: 10.1074/jbc.272.11.6979  0.396
1997 Chik CL, Liu QY, Li B, Klein DC, Zylka M, Kim DS, Chin H, Karpinski E, Ho AK. Alpha 1D L-type Ca(2+)-channel currents: inhibition by a beta-adrenergic agonist and pituitary adenylate cyclase-activating polypeptide (PACAP) in rat pinealocytes. Journal of Neurochemistry. 68: 1078-87. PMID 9048753  0.687
1997 Bernard M, Klein DC, Zatz M. Chick pineal clock regulates serotonin N-acetyltransferase mRNA rhythm in culture. Proceedings of the National Academy of Sciences of the United States of America. 94: 304-9. PMID 8990204 DOI: 10.1073/pnas.94.1.304  0.399
1997 Bernard M, Iuvone PM, Cassone VM, Roseboom PH, Coon SL, Klein DC. Avian melatonin synthesis: photic and circadian regulation of serotonin N-acetyltransferase mRNA in the chicken pineal gland and retina. Journal of Neurochemistry. 68: 213-24. PMID 8978728 DOI: 10.1046/J.1471-4159.1997.68010213.X  0.388
1996 Klein DC, Roseboom PH, Coon SL. New light is shining on the melatonin rhythm enzyme: the first postcloning view. Trends in Endocrinology and Metabolism: Tem. 7: 106-12. PMID 18406734 DOI: 10.1016/1043-2760(96)00033-1  0.392
1996 Bernard M, Voisin P, Klein DC. Hydroxyindole-O-methyltransferase in Y-79 cells: regulation by serum. Brain Research. 727: 118-24. PMID 8842389 DOI: 10.1016/0006-8993(96)00359-9  0.314
1996 Roseboom PH, Coon SL, Baler R, McCune SK, Weller JL, Klein DC. Melatonin synthesis: analysis of the more than 150-fold nocturnal increase in serotonin N-acetyltransferase messenger ribonucleic acid in the rat pineal gland. Endocrinology. 137: 3033-45. PMID 8770929 DOI: 10.1210/endo.137.7.8770929  0.43
1996 Weller JL, Jaffe H, Roseboom PH, Zylka MJ, Klein DC. 2D-PAGE analysis: adrenergically regulated pineal protein AIP 37/6 is a phosphorylated isoform of cytosolic malate dehydrogenase. Brain Research. 713: 8-16. PMID 8724970 DOI: 10.1016/0006-8993(95)01412-8  0.702
1996 Coon SL, Mazuruk K, Bernard M, Roseboom PH, Klein DC, Rodriguez IR. The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression. Genomics. 34: 76-84. PMID 8661026 DOI: 10.1006/geno.1996.0243  0.375
1996 Baler R, Coon S, Klein DC. Orphan nuclear receptor RZRbeta: cyclic AMP regulates expression in the pineal gland. Biochemical and Biophysical Research Communications. 220: 975-8. PMID 8607878 DOI: 10.1006/bbrc.1996.0517  0.348
1995 Bernard M, Donohue SJ, Klein DC. Human hydroxyindole-O-methyltransferase in pineal gland, retina and Y79 retinoblastoma cells. Brain Research. 696: 37-48. PMID 8574683 DOI: 10.1016/0006-8993(95)00651-6  0.339
1995 Vanecek J, Klein DC. Mechanism of melatonin signal transduction in the neonatal rat pituitary. Neurochemistry International. 27: 273-8. PMID 8520466 DOI: 10.1016/0197-0186(95)00032-4  0.327
1995 Vanecek J, Klein DC. Melatonin inhibition of GnRH-induced LH release from neonatal rat gonadotroph: involvement of Ca2+ not cAMP. The American Journal of Physiology. 269: E85-90. PMID 7631782 DOI: 10.1152/Ajpendo.1995.269.1.E85  0.305
1995 Baler R, Klein DC. Circadian expression of transcription factor Fra-2 in the rat pineal gland. The Journal of Biological Chemistry. 270: 27319-25. PMID 7592994 DOI: 10.1074/jbc.270.45.27319  0.382
1995 Coon SL, Roseboom PH, Baler R, Weller JL, Namboodiri MA, Koonin EV, Klein DC. Pineal serotonin N-acetyltransferase: expression cloning and molecular analysis. Science (New York, N.Y.). 270: 1681-3. PMID 7502081 DOI: 10.1126/Science.270.5242.1681  0.378
1994 Babila T, Klein DC. Cholera toxin-induced Gs alpha down-regulation in neural tissue: studies on the pineal gland. Brain Research. 638: 151-6. PMID 8199855 DOI: 10.1016/0006-8993(94)90644-0  0.309
1994 Roseboom PH, Weller JL, Babila T, Aitken A, Sellers LA, Moffett JR, Namboodiri MA, Klein DC. Cloning and characterization of the epsilon and zeta isoforms of the 14-3-3 proteins. Dna and Cell Biology. 13: 629-40. PMID 8024705 DOI: 10.1089/DNA.1994.13.629  0.343
1994 Lin AM, Schaad NC, Schulz PE, Coon SL, Klein DC. Pineal nitric oxide synthase: characteristics, adrenergic regulation and function. Brain Research. 651: 160-8. PMID 7522930 DOI: 10.1016/0006-8993(94)90693-9  0.357
1993 Vanecek J, Klein DC. A subpopulation of neonatal gonadotropin-releasing hormone-sensitive pituitary cells is responsive to melatonin. Endocrinology. 133: 360-7. PMID 8319582 DOI: 10.1210/endo.133.1.8319582  0.313
1993 White BH, Klein DC. Developmental appearance of pineal adrenergic-->guanosine 3',5'-monophosphate response is determined by a process down-stream from elevation of intracellular Ca2+: possible involvement of a diffusible factor. Endocrinology. 132: 1026-34. PMID 8095011 DOI: 10.1210/endo.132.3.8095011  0.365
1993 Yu L, Schaad NC, Klein DC. Calcium potentiates cyclic AMP stimulation of pineal arylalkylamine N-acetyltransferase. Journal of Neurochemistry. 60: 1436-43. PMID 7681102 DOI: 10.1111/J.1471-4159.1993.Tb03306.X  0.314
1992 Vanecek J, Klein DC. Melatonin inhibits gonadotropin-releasing hormone-induced elevation of intracellular Ca2+ in neonatal rat pituitary cells. Endocrinology. 130: 701-7. PMID 1733718 DOI: 10.1210/endo.130.2.1733718  0.323
1992 Babila T, Schaad NC, Klein DC. Rat pineal Gsa, Gia and Goa: relative abundance and development. Brain Research. 572: 232-5. PMID 1611517 DOI: 10.1016/0006-8993(92)90474-N  0.316
1992 Babila T, Schaad NC, Simonds WF, Shinohara T, Klein DC. Development of MEKA (phosducin), G beta, G gamma and S-antigen in the rat pineal gland and retina. Brain Research. 585: 141-8. PMID 1511297 DOI: 10.1016/0006-8993(92)91199-O  0.383
1992 Korf HW, White BH, Schaad NC, Klein DC. Recoverin in pineal organs and retinae of various vertebrate species including man. Brain Research. 595: 57-66. PMID 1467959 DOI: 10.1016/0006-8993(92)91452-K  0.34
1992 Babila T, Klein DC. Stimulus deprivation increases pineal Gs alpha and G beta. Journal of Neurochemistry. 59: 1356-62. PMID 1402887 DOI: 10.1111/j.1471-4159.1992.tb08448.x  0.364
1992 Weller JL, Klein DC. The pineal adrenergic----cyclic GMP response develops two weeks after the adrenergic----cyclic AMP response. Brain Research. Developmental Brain Research. 68: 144-7. PMID 1325876 DOI: 10.1016/0165-3806(92)90258-X  0.332
1992 Vanecek J, Klein DC. Sodium-dependent effects of melatonin on membrane potential of neonatal rat pituitary cells. Endocrinology. 131: 939-46. PMID 1322288 DOI: 10.1210/endo.131.2.1322288  0.313
1991 Schaad NC, Shinohara T, Abe T, Klein DC. Photoneural control of the synthesis and phosphorylation of pineal MEKA (phosducin). Endocrinology. 129: 3289-98. PMID 1659528 DOI: 10.1210/endo-129-6-3289  0.33
1990 Voisin P, Harrington MG, Weller JL, Goldman D, Merril CR, Klein DC. Noradrenergic control of the synthesis of two rat pineal proteins. Brain Research. 517: 25-34. PMID 2165434 DOI: 10.1016/0006-8993(90)91003-Y  0.366
1989 Ho AK, Chik CL, Klein DC. Forskolin stimulates pinealocyte cGMP accumulation. Dramatic potentiation by an alpha 1-adrenergic----[Ca2+]i mechanism involving protein kinase C. Febs Letters. 249: 207-12. PMID 2544448 DOI: 10.1016/0014-5793(89)80625-8  0.337
1989 McCabe RT, Schoenheimer JA, Skolnick P, Newman AH, Rice KC, Reig JA, Klein DC. [3H]AHN 086 acylates peripheral benzodiazepine receptors in the rat pineal gland. Febs Letters. 244: 263-7. PMID 2537753 DOI: 10.1016/0014-5793(89)80541-1  0.324
1988 Sugden D, Ho AK, Sugden AL, Klein DC. Negative feedback mechanisms: evidence that desensitization of pineal alpha 1-adrenergic responses involves protein kinase-C. Endocrinology. 123: 1425-32. PMID 2841094 DOI: 10.1210/Endo-123-3-1425  0.306
1988 Ho AK, Chik CL, Klein DC. Effects of protein kinase inhibitor (1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7) on protein kinase C activity and adrenergic stimulation of cAMP and cGMP in rat pinealocytes. Biochemical Pharmacology. 37: 1015-20. PMID 2833269 DOI: 10.1016/0006-2952(88)90503-5  0.316
1988 Chik CL, Ho AK, Klein DC. Dual receptor regulation of cyclic nucleotides: alpha 1-adrenergic potentiation of vasoactive intestinal peptide stimulation of pinealocyte adenosine 3',5'-monophosphate. Endocrinology. 122: 1646-51. PMID 2831037 DOI: 10.1210/endo-122-4-1646  0.322
1988 Sugden D, Klein DC. Activators of protein kinase C act at a postreceptor site to amplify cyclic AMP production in rat pinealocytes. Journal of Neurochemistry. 50: 149-55. PMID 2447232 DOI: 10.1111/J.1471-4159.1988.Tb13242.X  0.313
1987 Ho AK, Klein DC. Phosphatidylinositol phosphodiesterase (phospholipase C) activity in the pineal gland: characterization and photoneural regulation. Journal of Neurochemistry. 48: 1033-8. PMID 3819719 DOI: 10.1111/J.1471-4159.1987.Tb05622.X  0.313
1987 Yanovski J, Witcher J, Adler N, Markey SP, Klein DC. Stimulation of the paraventricular nucleus area of the hypothalamus elevates urinary 6-hydroxymelatonin during daytime. Brain Research Bulletin. 19: 129-33. PMID 3651836 DOI: 10.1016/0361-9230(87)90175-4  0.318
1987 Namboodiri MA, Brownstein MJ, Weller J, Voisin P, Klein DC. Multiple forms of arylalkylamine N-acetyltransferases in the rat pineal gland: purification of one molecular form. Journal of Pineal Research. 4: 235-46. PMID 3625455 DOI: 10.1111/J.1600-079X.1987.Tb00861.X  0.316
1987 Ho AK, Chik CL, Klein DC. Transmembrane receptor cross-talk: concurrent VIP and alpha 1-adrenergic activation rapidly elevates pinealocyte cGMP greater than 100-fold. Biochemical and Biophysical Research Communications. 146: 1478-84. PMID 3040005 DOI: 10.1016/0006-291X(87)90816-3  0.358
1986 Ho AK, Somers RL, Klein DC. Development and regulation of rhodopsin kinase in rat pineal and retina. Journal of Neurochemistry. 46: 1176-9. PMID 3950623 DOI: 10.1111/J.1471-4159.1986.Tb00634.X  0.382
1986 Sugden D, Voisin P, Klein DC. Purification of rat pineal hydroxyindole-O-methyltransferase using S-adenosyl-L-homocysteine agarose chromatography. Journal of Pineal Research. 3: 389-95. PMID 3783420 DOI: 10.1111/j.1600-079X.1986.tb00761.x  0.308
1986 Vanecek J, Sugden D, Weller JL, Klein DC. See-saw signal processing in pinealocytes involves reciprocal changes in the alpha 1-adrenergic component of the cyclic GMP response and the beta-adrenergic component of the cyclic AMP response. Journal of Neurochemistry. 47: 678-86. PMID 3016179 DOI: 10.1111/j.1471-4159.1986.tb00665.x  0.316
1985 Namboodiri MA, Sugden D, Klein DC, Tamarkin L, Mefford IN. Serum melatonin and pineal indoleamine metabolism in a species with a small day/night N-acetyltransferase rhythm. Comparative Biochemistry and Physiology. B, Comparative Biochemistry. 80: 731-6. PMID 3995918 DOI: 10.1016/0305-0491(85)90453-5  0.39
1985 Klein DC, Voisin P, Namboodiri MA. The pineal family of aromatic amine N-acetyltransferases. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 3: 217-20. PMID 3842594 DOI: 10.1002/bies.950030508  0.325
1985 Vanecek J, Sugden D, Weller J, Klein DC. Atypical synergistic alpha 1- and beta-adrenergic regulation of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in rat pinealocytes. Endocrinology. 116: 2167-73. PMID 2986940 DOI: 10.1210/endo-116-6-2167  0.321
1985 Sugden D, Vanecek J, Klein DC, Thomas TP, Anderson WB. Activation of protein kinase C potentiates isoprenaline-induced cyclic AMP accumulation in rat pinealocytes. Nature. 314: 359-61. PMID 2984573 DOI: 10.1038/314359A0  0.34
1985 Sugden D, Klein DC. Regulation of rat pineal alpha 1-adrenoceptors. Journal of Neurochemistry. 44: 63-7. PMID 2856885 DOI: 10.1111/j.1471-4159.1985.tb07113.x  0.357
1985 Namboodiri MA, Sugden D, Klein DC, Grady R, Mefford IN. Rapid nocturnal increase in ovine pineal N-acetyltransferase activity and melatonin synthesis: effects of cycloheximide. Journal of Neurochemistry. 45: 832-5. PMID 2411856 DOI: 10.1111/J.1471-4159.1985.Tb04069.X  0.334
1984 Klein DC. Melatonin and puberty. Science (New York, N.Y.). 224: 6. PMID 6701534 DOI: 10.1126/Science.6701534  0.331
1984 Rollag MD, Welsh MG, Klein DC. Effect of acute light exposure upon melatonin content, NAT activity, and nuclear volume in the gerbil pineal complex. Journal of Pineal Research. 1: 339-47. PMID 6545826 DOI: 10.1111/J.1600-079X.1984.Tb00224.X  0.398
1984 Reppert SM, Perlow MJ, Artman HG, Ungerleider LG, Fisher DA, Klein DC. The circadian rhythm of oxytocin in primate cerebrospinal fluid: effects of destruction of the suprachiasmatic nuclei. Brain Research. 307: 384-7. PMID 6467006 DOI: 10.1016/0006-8993(84)90501-8  0.562
1984 Klein DC, Somers R. Presence of rhodopsin kinase in the rat pineal gland Journal of Steroid Biochemistry. 20: 1455. DOI: 10.1016/0022-4731(84)90596-X  0.309
1983 Sugden D, Klein DC. Regulation of rat pineal hydroxyindole-O-methyltransferase in neonatal and adult rats. Journal of Neurochemistry. 40: 1647-53. PMID 6854324 DOI: 10.1111/J.1471-4159.1983.Tb08138.X  0.375
1983 Sugden D, Klein DC. Adrenergic stimulation of rat pineal hydroxyindole-O-methyltransferase. Brain Research. 265: 348-51. PMID 6850338 DOI: 10.1016/0006-8993(83)90355-4  0.348
1983 Klein DC, Smoot R, Weller JL, Higa S, Markey SP, Creed GJ, Jacobowitz DM. Lesions of the paraventricular nucleus area of the hypothalamus disrupt the suprachiasmatic leads to spinal cord circuit in the melatonin rhythm generating system. Brain Research Bulletin. 10: 647-52. PMID 6307491 DOI: 10.1016/0361-9230(83)90033-3  0.316
1983 Sugden D, Klein DC. Beta-adrenergic receptor control of rat pineal hydroxyindole-O-methyltransferase. Endocrinology. 113: 348-53. PMID 6305637 DOI: 10.1210/endo-113-1-348  0.354
1983 Mefford IN, Chang P, Klein DC, Namboodiri MA, Sugden D, Barchas J. Reciprocal day/night relationship between serotonin oxidation and N-acetylation products in the rat pineal gland. Endocrinology. 113: 1582-6. PMID 6194975 DOI: 10.1210/Endo-113-5-1582  0.31
1983 Klein DC, Sugden D, Weller JL. Postsynaptic alpha-adrenergic receptors potentiate the beta-adrenergic stimulation of pineal serotonin N-acetyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 80: 599-603. PMID 6132380 DOI: 10.1073/Pnas.80.2.599  0.322
1982 Klein DC, Namboodiri M. Control of the circadian rhythm in pineal serotonin N-acetyltransferase activity: possible role of protein thiol: disulfide exchange Trends in Biochemical Sciences. 7: 98-102. DOI: 10.1016/0968-0004(82)90156-6  0.37
1981 Reppert SM, Perlow MJ, Ungerleider LG, Mishkin M, Tamarkin L, Orloff DG, Hoffman HJ, Klein DC. Effects of damage to the suprachiasmatic area of the anterior hypothalamus on the daily melatonin and cortisol rhythms in the rhesus monkey. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 1: 1414-25. PMID 7320754 DOI: 10.1523/Jneurosci.01-12-01414.1981  0.588
1981 Reppert SM, Perlow MJ, Tamarkin L, Orloff D, Klein DC. The effects of environmental lighting on the daily melatonin rhythm in primate cerebrospinal fluid. Brain Research. 223: 313-23. PMID 7284813 DOI: 10.1016/0006-8993(81)91144-6  0.585
1981 Perlow MJ, Reppert SM, Boyar RM, Klein DC. Daily rhythms in cortisol and melatonin in primate cerebrospinal fluid. Effects of constant light and dark. Neuroendocrinology. 32: 193-6. PMID 7194425 DOI: 10.1159/000123157  0.581
1981 Klein DC, Auerbach DA, Weller JL. Seesaw signal processing in pineal cells: homologous sensitization of adrenergic stimulation of cyclic GMP accompanies homologous desensitization of beta-adrenergic stimulation of cyclic AMP. Proceedings of the National Academy of Sciences of the United States of America. 78: 4625-9. PMID 6270688 DOI: 10.1073/Pnas.78.7.4625  0.343
1981 Klein DC, Namboodiri MA, Auerbach DA. The melatonin rhythm generating system: developmental aspects. Life Sciences. 28: 1975-86. PMID 6264261 DOI: 10.1016/0024-3205(81)90644-5  0.315
1981 Kapatos G, Kaufman S, Weller JL, Klein DC. Biosynthesis of biopterin: adrenergic cyclic adenosine monophosphate-dependent inhibition in the pineal gland. Science (New York, N.Y.). 213: 1129-31. PMID 6168019 DOI: 10.1126/Science.6168019  0.329
1980 Tamarkin L, Reppert SM, Klein DC, Pratt B, Goldman BD. Studies on the daily pattern of pineal melatonin in the Syrian hamster. Endocrinology. 107: 1525-9. PMID 7428680 DOI: 10.1210/Endo-107-5-1525  0.604
1980 Tamarkin L, Reppert SM, Orloff DJ, Klein DC, Yellon SM, Goldman BD. Ontogeny of the pineal melatonin rhythm in the Syrian (Mesocricetus auratus) and Siverian (Phodopus sungorus) hamsters and in the rat. Endocrinology. 107: 1061-4. PMID 7408759 DOI: 10.1210/Endo-107-4-1061  0.6
1980 Martin JE, McKellar S, Klein DC. Melatonin inhibition of the in vivo pituitary response to luteinizing hormone-releasing hormone in the neonatal rat. Neuroendocrinology. 31: 13-7. PMID 6993981 DOI: 10.1159/000123044  0.361
1980 Martin JE, Kirk KL, Klein DC. Effects of 6-hydroxy-, 6-fluoro-, and 4,6-difluoromelatonin on the in vitro pituitary response to luteinizing hormone-releasing hormone. Endocrinology. 106: 398-401. PMID 6985588 DOI: 10.1210/endo-106-1-398  0.341
1980 Perlow MJ, Reppert SM, Tamarkin L, Wyatt RJ, Klein DC. Photic regulation of the melatonin rhythm: monkey and man are not the same. Brain Research. 182: 211-6. PMID 6766079 DOI: 10.1016/0006-8993(80)90848-3  0.575
1980 Namboodiri MA, Weller JL, Klein DC. Rapid and reversible activation of acetyl CoA hydrolase in intact pineal cells by disulfide exchange. Biochemical and Biophysical Research Communications. 96: 188-95. PMID 6108107 DOI: 10.1016/0006-291X(80)91199-7  0.32
1979 Klein DC, Moore RY. Pineal N-acetyltransferase and hydroxyindole-O-methyltransferase: control by the retinohypothalamic tract and the suprachiasmatic nucleus. Brain Research. 174: 245-62. PMID 487129 DOI: 10.1016/0006-8993(79)90848-5  0.345
1979 Tamarkin L, Reppert SM, Klein DC. Regulation of pineal melatonin in the Syrian hamster. Endocrinology. 104: 385-9. PMID 446367 DOI: 10.1210/endo-104-2-385  0.594
1979 Wheler GH, Weller JL, Klein DC. Taurine: stimulation of pineal N-acetyltransferase activity and melatonin production via a beta-adrenergic mechanism. Brain Research. 166: 65-74. PMID 217502 DOI: 10.1016/0006-8993(79)90650-4  0.345
1979 Reppert SM, Chez RA, Anderson A, Klein DC. Maternal-fetal transfer of melatonin in the non-human primate. Pediatric Research. 13: 788-91. PMID 113767 DOI: 10.1203/00006450-197906000-00015  0.561
1979 Reppert SM, Perlow MJ, Tamarkin L, Klein DC. A diurnal melatonin rhythm in primate cerebrospinal fluid. Endocrinology. 104: 295-301. PMID 109277 DOI: 10.1210/endo-104-2-295  0.571
1979 Namboodiri MA, Favilla JT, Klein DC. Activation of pineal and brain acetyl-COA hydrolase by cystamine: an apparent case of disulfide exchange. Biochemical and Biophysical Research Communications. 91: 1166-73. PMID 43149 DOI: 10.1016/0006-291X(79)92002-3  0.321
1979 Namboodiri MA, Namboodiri MA, Weller JL, Klein DC. A comparative study of pineal acetyl-CoA hydrolase and N-acetyltransferase activities. Journal of Neurochemistry. 32: 31-3. PMID 32232 DOI: 10.1111/J.1471-4159.1979.Tb04506.X  0.374
1978 Buda M, Klein DC. A suspension culture of pinealocytes: regulation of N-acetyltransferase activity. Endocrinology. 103: 1483-93. PMID 744160 DOI: 10.1210/endo-103-4-1483  0.361
1978 Reppert SM, Klein DC. Transport of maternal[3H]melatonin to suckling rats and the fate of [3H]melatonin in the neonatal rat. Endocrinology. 102: 582-8. PMID 743980 DOI: 10.1210/endo-102-2-582  0.576
1978 Reppert SM, Chez RA, Klein DC. Maternal-fetal transfer of melatonin in the nonhuman primate Pediatric Research. 12: No. 331.  0.449
1977 Yuwiler A, Klein DC, Buda M, Weller JL. Adrenergic control of pineal N-acetyltransferase activity: developmental aspects. The American Journal of Physiology. 233: E141-6. PMID 910899 DOI: 10.1152/Ajpendo.1977.233.3.E141  0.387
1977 Martin JE, Engel JN, Klein DC. Inhibition of the in vitro pituitary response to luteinizing hormone-releasing hormone by melatonin, serotonin, and 5-methoxytryptamine. Endocrinology. 100: 675-80. PMID 401360 DOI: 10.1210/Endo-100-3-675  0.334
1977 Reppert SM, Klein DC, Schulman JD. MILK TRANSPORT OF |[lsqb]|3H|[rsqb]|MELATONIN TO SUCKLING RATS Pediatric Research. 11: 420-420. DOI: 10.1203/00006450-197704000-00306  0.57
1977 Reppert SM, Klein DC. Milk transport of [3H]melatonin to suckling rats Pediatric Research. 11: No.292.  0.5
1976 Chen CH, Klein DC, Robinson JC. Monoamine oxidase in rat placenta, human placenta, and cultured choriocarcinoma. Journal of Reproduction and Fertility. 46: 477-9. PMID 1255585 DOI: 10.1530/Jrf.0.0460477  0.332
1976 Martin JE, Klein DC. Melatonin inhibition of the neonatal pituitary response to luteinizing hormone-releasing factor. Science (New York, N.Y.). 191: 301-2. PMID 1108199 DOI: 10.1126/Science.1108199  0.327
1976 Parfitt AG, Klein DC. Sympathetic nerve endings in the pineal gland protect against acute stress-induced increase in N-acetyltransferase (EC 2.3.1.5.) activity. Endocrinology. 99: 840-51. PMID 954673 DOI: 10.1210/endo-99-3-840  0.347
1976 Martin JE, Klein DC. Long-term organ culture of rat anterior pituitary glands. Endocrinology. 99: 1189-98. PMID 791638 DOI: 10.1210/endo-99-5-1189  0.344
1976 Parfitt A, Weller JL, Klein DC. Beta adrenergic-blockers decrease adrenergically stimulated N-acetyltransferase activity in pineal glands in organ culture. Neuropharmacology. 15: 353-8. PMID 6923 DOI: 10.1016/0028-3908(76)90083-6  0.338
1975 Ralph CL, Binkley S, MacBride SE, Klein DC. Regulation of pineal rhythms in chickens: effects of blinding, constant light, constant dark, and superior cervical ganglionectomy. Endocrinology. 97: 1373-8. PMID 1239366 DOI: 10.1210/endo-97-6-1373  0.371
1975 Binkley S, Macbride SE, Klein DC, Ralph CL. Regulation of pineal rhythms in chickens: refractory period and nonvisual light perception. Endocrinology. 96: 848-53. PMID 1120473 DOI: 10.1210/endo-96-4-848  0.389
1974 Moore RY, Klein DC. Visual pathways and the central neural control of a circadian rhythm in pineal serotonin N-acetyltransferase activity. Brain Research. 71: 17-33. PMID 4595289 DOI: 10.1016/0006-8993(74)90188-7  0.362
1974 Bensinger RE, Klein DC, Weller JL, Lovenberg W. Radiometric assay of total tryptophan hydroxylation by intact cultured pineal glands. Journal of Neurochemistry. 23: 111-7. PMID 4546896 DOI: 10.1111/J.1471-4159.1974.Tb06923.X  0.327
1974 Schrier BK, Klein DC. Absence of choline acetyltransferase in rat and rabbit pineal gland. Brain Research. 79: 347-51. PMID 4422287 DOI: 10.1016/0006-8993(74)90431-4  0.327
1974 Chen CH, Klein DC, Robinson JC. Catechol-O-methyltransferase in rat placenta, human placenta and choriocarcinoma grown in culture. Journal of Reproduction and Fertility. 39: 407-10. PMID 4412347 DOI: 10.1530/Jrf.0.0390407  0.317
1973 Ulrich R, Yuwiler A, Wetterberg L, Klein D. Effects of light and temperature on the pineal gland in suckling rats. Neuroendocrinology. 13: 255-63. PMID 4779326 DOI: 10.1159/000122210  0.345
1973 Binkley SA, Klein DC, Weller JL. Dark induced increase in pineal serotonin N-acetyltransferase activity: a refractory period. Experientia. 29: 1339-40. PMID 4761229 DOI: 10.1007/Bf01922804  0.334
1973 Klein DC, Yuwiler A, Weller JL, Plotkin S. Postsynaptic adrenergic-cyclic AMP control of the serotonin content of cultured rat pineal glands. Journal of Neurochemistry. 21: 1261-71. PMID 4357502 DOI: 10.1111/J.1471-4159.1973.Tb07580.X  0.321
1973 Binkley S, Macbride SE, Klein DC, Ralph CL. Pineal Enzymes: Regulation of Avian Melatonin Synthesis Science. 181: 273-275. DOI: 10.1126/science.181.4096.273-a  0.381
1973 Klein DC, Yuwiler A, Bensinger R. Beta adrenergic regulation of serotonin in the cultured rat pineal gland Life Sciences. 13: LXXXVI-LXXXVII. DOI: 10.1016/0024-3205(73)90310-X  0.32
1972 Klein DC, Weller JL. Rapid light-induced decrease in pineal serotonin N-acetyltransferase activity. Science (New York, N.Y.). 177: 532-3. PMID 5050487 DOI: 10.1126/Science.177.4048.532  0.395
1972 Ellison N, Weller JL, Klein DC. Development of a circadian rhythm in the activity of pineal serotonin N-acetyltransferase. Journal of Neurochemistry. 19: 1335-41. PMID 5025129 DOI: 10.1111/J.1471-4159.1972.Tb01458.X  0.402
1972 Klein DC. Evidence for the placental transfer of 3 H-acetyl-melatonin. Nature: New Biology. 237: 117-8. PMID 4503849 DOI: 10.1038/Newbio237117A0  0.364
1972 Strada SJ, Klein DC, Weller J, Weiss B. Effect of norepinephrine on the concentration of adenosine 3',5'-monophosphate of rat pineal gland in organ culture. Endocrinology. 90: 1470-5. PMID 4401741 DOI: 10.1210/endo-90-6-1470  0.348
1972 Klein DC, Weller J. Input and output signals in a model neural system: the regulation of melatonin production in the pineal gland. In Vitro. 6: 197-204. PMID 4331703 DOI: 10.1007/BF02617764  0.367
1972 Silberstein SD, Lemberger L, Klein DC, Axelrod J, Kopin IJ. Induction of adrenal tyrosine hydroxylase in organ culture. Neuropharmacology. 11: 721-6. PMID 4151251 DOI: 10.1016/0028-3908(72)90081-0  0.325
1971 Klein DC, Reiter RJ, Weller JL. Pineal N-acetyltransferase activity in blinded and anosmic male rats. Endocrinology. 89: 1020-3. PMID 5092653 DOI: 10.1210/endo-89-4-1020  0.348
1971 Klein DC, Weller JL, Moore RY. Melatonin metabolism: neural regulation of pineal serotonin: acetyl coenzyme A N-acetyltransferase activity. Proceedings of the National Academy of Sciences of the United States of America. 68: 3107-10. PMID 4332009 DOI: 10.1073/Pnas.68.12.3107  0.396
1971 Berg GR, Klein DC. Pineal gland in organ culture. II. Role of adenosine 3',5'-monophosphate in the regulation of radiolabeled melatonin production. Endocrinology. 89: 453-64. PMID 4326791 DOI: 10.1210/endo-89-2-453  0.362
1971 Reiter RJ, Klein DC. Observations on the pineal gland, the Harderian glands, the retina, and the reproductive organs of adult female rats exposed to continuous light. The Journal of Endocrinology. 51: 117-25. PMID 4108164 DOI: 10.1677/Joe.0.0510117  0.334
1970 Rowe JW, Richert JR, Klein DC, Reichlin S. Relation of the pineal gland and environmental lighting to thyroid function in the rat. Neuroendocrinology. 6: 247-54. PMID 5473375 DOI: 10.1159/000121930  0.344
1970 Klein DC, Weller JL. Indole metabolism in the pineal gland: a circadian rhythm in N-acetyltransferase. Science (New York, N.Y.). 169: 1093-5. PMID 4915470 DOI: 10.1126/science.169.3950.1093  0.409
1970 Klein DC, Berg GR, Weller J. Melatonin synthesis: adenosine 3',5'-monophosphate and norepinephrine stimulate N-acetyltransferase. Science (New York, N.Y.). 168: 979-80. PMID 4314985 DOI: 10.1126/science.168.3934.979  0.351
1970 Klein DC, Berg GR, Weller J, Glinsmann W. Pineal gland: dibutyryl cyclic adenosine monophosphate stimulation of labeled melatonin production. Science (New York, N.Y.). 167: 1738-40. PMID 4313580 DOI: 10.1126/science.167.3926.1738  0.325
1969 Klein DC, Lines SV. Pineal hydroxyindole-O-methyl transferase activity in the growing rat. Endocrinology. 84: 1523-5. PMID 5781132 DOI: 10.1210/endo-84-6-1523  0.348
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