| Year |
Citation |
Score |
| 2023 |
Rossio V, Paulo JA, Liu X, Gygi SP, King RW. Substrate identification and specificity profiling of deubiquitylases against endogenously-generated ubiquitin-protein conjugates. Biorxiv : the Preprint Server For Biology. PMID 38187689 DOI: 10.1101/2023.12.20.572581 |
0.32 |
|
| 2021 |
Rossio V, Paulo JA, Chick J, Brasher B, Gygi SP, King RW. Proteomics of broad deubiquitylase inhibition unmasks redundant enzyme function to reveal substrates and assess enzyme specificity. Cell Chemical Biology. PMID 33417828 DOI: 10.1016/j.chembiol.2020.12.007 |
0.313 |
|
| 2020 |
Manohar S, Yu Q, Gygi SP, King RW. The insulin receptor adaptor IRS2 is an APC/C substrate that promotes cell cycle protein expression and a robust spindle assembly checkpoint. Molecular & Cellular Proteomics : McP. PMID 32554797 DOI: 10.1074/Mcp.Ra120.002069 |
0.436 |
|
| 2020 |
Richeson KV, Bodrug T, Sackton KL, Yamaguchi M, Paulo JA, Gygi SP, Schulman BA, Brown NG, King RW. Paradoxical mitotic exit induced by a small molecule inhibitor of APC/C. Nature Chemical Biology. PMID 32152539 DOI: 10.1038/S41589-020-0495-Z |
0.421 |
|
| 2017 |
Boselli M, Lee BH, Robert J, Prado MA, Min SW, Cheng C, Silva MC, Seong C, Elsasser S, Hatle KM, Gahman TC, Gygi SP, Haggarty SJ, Gan L, King RW, et al. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. The Journal of Biological Chemistry. PMID 28972160 DOI: 10.1074/Jbc.M117.815126 |
0.44 |
|
| 2016 |
Lee BH, Lu Y, Prado MA, Shi Y, Tian G, Sun S, Elsasser S, Gygi SP, King RW, Finley D. USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites. Nature. PMID 27074503 DOI: 10.1038/Nature17433 |
0.56 |
|
| 2015 |
Lub S, Maes A, Maes K, De Veirman K, De Bruyne E, Menu E, Fostier K, Kassambara A, Moreaux J, Hose D, Leleu X, King RW, Vanderkerken K, Van Valckenborgh E. Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells. Oncotarget. PMID 26716651 DOI: 10.18632/Oncotarget.6768 |
0.395 |
|
| 2015 |
de Lange J, Faramarz A, Oostra AB, de Menezes RX, van der Meulen IH, Rooimans MA, Rockx DA, Brakenhoff RH, van Beusechem VW, King RW, de Winter JP, Wolthuis RM. Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function. Nature Communications. 6: 8399. PMID 26423134 DOI: 10.1038/Ncomms9399 |
0.382 |
|
| 2015 |
Lu Y, Lee BH, King RW, Finley D, Kirschner MW. Substrate degradation by the proteasome: a single-molecule kinetic analysis. Science (New York, N.Y.). 348: 1250834. PMID 25859050 DOI: 10.1126/Science.1250834 |
0.623 |
|
| 2014 |
King RW, Finley D. Sculpting the proteome with small molecules. Nature Chemical Biology. 10: 870-4. PMID 25325686 DOI: 10.1038/Nchembio.1671 |
0.422 |
|
| 2014 |
Sackton KL, Dimova N, Zeng X, Tian W, Zhang M, Sackton TB, Meaders J, Pfaff KL, Sigoillot F, Yu H, Luo X, King RW. Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature. 514: 646-9. PMID 25156254 DOI: 10.1038/Nature13660 |
0.799 |
|
| 2013 |
Lim HJ, Dimova NV, Tan MK, Sigoillot FD, King RW, Shi Y. The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20. Molecular and Cellular Biology. 33: 4166-80. PMID 23979597 DOI: 10.1128/Mcb.00689-13 |
0.764 |
|
| 2013 |
Pfaff KL, King RW. Determinants of human cyclin B1 association with mitotic chromosomes. Plos One. 8: e59169. PMID 23505570 DOI: 10.1371/Journal.Pone.0059169 |
0.362 |
|
| 2012 |
Lee BH, Finley D, King RW. A High-Throughput Screening Method for Identification of Inhibitors of the Deubiquitinating Enzyme USP14. Current Protocols in Chemical Biology. 4: 311-30. PMID 23788557 DOI: 10.1002/9780470559277.Ch120078 |
0.399 |
|
| 2012 |
Zeng X, King RW. An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nature Chemical Biology. 8: 383-92. PMID 22366722 DOI: 10.1038/Nchembio.801 |
0.647 |
|
| 2012 |
Adamson B, Smogorzewska A, Sigoillot FD, King RW, Elledge SJ. A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Nature Cell Biology. 14: 318-28. PMID 22344029 DOI: 10.1038/Ncb2426 |
0.34 |
|
| 2012 |
Sigoillot FD, Lyman S, Huckins JF, Adamson B, Chung E, Quattrochi B, King RW. A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens. Nature Methods. 9: 363-6. PMID 22343343 DOI: 10.1038/Nmeth.1898 |
0.322 |
|
| 2012 |
Dimova NV, Hathaway NA, Lee BH, Kirkpatrick DS, Berkowitz ML, Gygi SP, Finley D, King RW. APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1. Nature Cell Biology. 14: 168-76. PMID 22286100 DOI: 10.1038/Ncb2425 |
0.781 |
|
| 2011 |
Miduturu CV, Deng X, Kwiatkowski N, Yang W, Brault L, Filippakopoulos P, Chung E, Yang Q, Schwaller J, Knapp S, King RW, Lee JD, Herrgard S, Zarrinkar P, Gray NS. High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chemistry & Biology. 18: 868-79. PMID 21802008 DOI: 10.1016/J.Chembiol.2011.05.010 |
0.349 |
|
| 2011 |
Harper JW, King RW. Stuck in the middle: drugging the ubiquitin system at the e2 step. Cell. 145: 1007-9. PMID 21703444 DOI: 10.1016/J.Cell.2011.06.002 |
0.362 |
|
| 2011 |
Krajcovic M, Johnson NB, Sun Q, Normand G, Hoover N, Yao E, Richardson AL, King RW, Cibas ES, Schnitt SJ, Brugge JS, Overholtzer M. A non-genetic route to aneuploidy in human cancers. Nature Cell Biology. 13: 324-30. PMID 21336303 DOI: 10.1038/Ncb2174 |
0.314 |
|
| 2011 |
Sigoillot FD, King RW. Vigilance and validation: Keys to success in RNAi screening. Acs Chemical Biology. 6: 47-60. PMID 21142076 DOI: 10.1021/Cb100358F |
0.32 |
|
| 2011 |
Lee MJ, Lee BH, Hanna J, King RW, Finley D. Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes. Molecular & Cellular Proteomics : McP. 10: R110.003871. PMID 20823120 DOI: 10.1074/Mcp.R110.003871 |
0.429 |
|
| 2010 |
Zeng X, Sigoillot F, Gaur S, Choi S, Pfaff KL, Oh DC, Hathaway N, Dimova N, Cuny GD, King RW. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 18: 382-95. PMID 20951947 DOI: 10.1016/J.Ccr.2010.08.010 |
0.76 |
|
| 2010 |
Lee BH, Lee MJ, Park S, Oh DC, Elsasser S, Chen PC, Gartner C, Dimova N, Hanna J, Gygi SP, Wilson SM, King RW, Finley D. Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature. 467: 179-84. PMID 20829789 DOI: 10.1038/Nature09299 |
0.788 |
|
| 2010 |
Normand G, King RW. Understanding cytokinesis failure. Advances in Experimental Medicine and Biology. 676: 27-55. PMID 20687468 DOI: 10.1007/978-1-4419-6199-0_3 |
0.383 |
|
| 2008 |
King RW. When 2+2=5: the origins and fates of aneuploid and tetraploid cells. Biochimica Et Biophysica Acta. 1786: 4-14. PMID 18703117 DOI: 10.1016/J.Bbcan.2008.07.007 |
0.323 |
|
| 2007 |
Overholtzer M, Mailleux AA, Mouneimne G, Normand G, Schnitt SJ, King RW, Cibas ES, Brugge JS. A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion. Cell. 131: 966-79. PMID 18045538 DOI: 10.1016/J.Cell.2007.10.040 |
0.31 |
|
| 2007 |
Kleijnen MF, Roelofs J, Park S, Hathaway NA, Glickman M, King RW, Finley D. Stability of the proteasome can be regulated allosterically through engagement of its proteolytic active sites. Nature Structural & Molecular Biology. 14: 1180-8. PMID 18026118 DOI: 10.1038/Nsmb1335 |
0.738 |
|
| 2007 |
Bentley AM, Normand G, Hoyt J, King RW. Distinct sequence elements of cyclin B1 promote localization to chromatin, centrosomes, and kinetochores during mitosis. Molecular Biology of the Cell. 18: 4847-58. PMID 17881737 DOI: 10.1091/Mbc.E06-06-0539 |
0.418 |
|
| 2006 |
Crosas B, Hanna J, Kirkpatrick DS, Zhang DP, Tone Y, Hathaway NA, Buecker C, Leggett DS, Schmidt M, King RW, Gygi SP, Finley D. Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities. Cell. 127: 1401-13. PMID 17190603 DOI: 10.1016/J.Cell.2006.09.051 |
0.746 |
|
| 2006 |
Hanna J, Hathaway NA, Tone Y, Crosas B, Elsasser S, Kirkpatrick DS, Leggett DS, Gygi SP, King RW, Finley D. Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation. Cell. 127: 99-111. PMID 17018280 DOI: 10.1016/J.Cell.2006.07.038 |
0.743 |
|
| 2006 |
Kirkpatrick DS, Hathaway NA, Hanna J, Elsasser S, Rush J, Finley D, King RW, Gygi SP. Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology. Nature Cell Biology. 8: 700-10. PMID 16799550 DOI: 10.1038/Ncb1436 |
0.761 |
|
| 2006 |
Shi Q, King RW. Cell biology: Shi & King reply Nature. 442: E10. DOI: 10.1038/Nature05140 |
0.337 |
|
| 2005 |
Stern HM, Murphey RD, Shepard JL, Amatruda JF, Straub CT, Pfaff KL, Weber G, Tallarico JA, King RW, Zon LI. Small molecules that delay S phase suppress a zebrafish bmyb mutant. Nature Chemical Biology. 1: 366-70. PMID 16372403 DOI: 10.1038/Nchembio749 |
0.449 |
|
| 2005 |
Hoyt J, King RW. Adenoviral expression of reporter proteins for high-throughput cell-based screening. Methods in Molecular Biology (Clifton, N.J.). 310: 187-95. PMID 16353377 DOI: 10.1007/978-1-59259-948-6_13 |
0.331 |
|
| 2005 |
Salic A, King RW. Identifying small molecule inhibitors of the ubiquitin-proteasome pathway in Xenopus egg extracts. Methods in Enzymology. 399: 567-85. PMID 16338382 DOI: 10.1016/S0076-6879(05)99038-1 |
0.733 |
|
| 2005 |
Shi Q, King RW. Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. Nature. 437: 1038-42. PMID 16222248 DOI: 10.1038/Nature03958 |
0.317 |
|
| 2005 |
Lorang J, King RW. Cytological profiling: providing more haystacks for chemists' needles. Genome Biology. 6: 228. PMID 16086858 DOI: 10.1186/Gb-2005-6-8-228 |
0.393 |
|
| 2005 |
Hathaway NA, King RW. Dissecting cell biology with chemical scalpels. Current Opinion in Cell Biology. 17: 12-9. PMID 15661514 DOI: 10.1016/J.Ceb.2004.12.004 |
0.758 |
|
| 2004 |
Tochtrop GP, King RW. Target identification strategies in chemical genetics. Combinatorial Chemistry & High Throughput Screening. 7: 677-88. PMID 15578930 DOI: 10.2174/1386207043328391 |
0.652 |
|
| 2004 |
Verma R, Peters NR, D'Onofrio M, Tochtrop GP, Sakamoto KM, Varadan R, Zhang M, Coffino P, Fushman D, Deshaies RJ, King RW. Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain. Science (New York, N.Y.). 306: 117-20. PMID 15459393 DOI: 10.1126/Science.1100946 |
0.787 |
|
| 2004 |
Cheng D, Yadav N, King RW, Swanson MS, Weinstein EJ, Bedford MT. Small molecule regulators of protein arginine methyltransferases. The Journal of Biological Chemistry. 279: 23892-9. PMID 15056663 DOI: 10.1074/Jbc.M401853200 |
0.46 |
|
| 2002 |
King RW. Roughing up Smoothened: chemical modulators of hedgehog signaling. Journal of Biology. 1: 8. PMID 12437769 DOI: 10.1186/1475-4924-1-8 |
0.328 |
|
| 2001 |
Clemons PA, Koehler AN, Wagner BK, Sprigings TG, Spring DR, King RW, Schreiber SL, Foley MA. A one-bead, one-stock solution approach to chemical genetics: part 2. Chemistry & Biology. 8: 1183-95. PMID 11755397 DOI: 10.1016/S1074-5521(01)00086-2 |
0.475 |
|
| 2001 |
Haggarty SJ, Mayer TU, Miyamoto DT, Fathi R, King RW, J. Mitchison T, Schreiber SL. Erratum to ‘Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis’ Chemistry & Biology. 8: 1265. DOI: 10.1016/S1074-5521(01)00083-7 |
0.466 |
|
| 2000 |
Haggarty SJ, Mayer TU, Miyamoto DT, Fathi R, King RW, Mitchison TJ, Schreiber SL. Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis. Chemistry & Biology. 7: 275-86. PMID 10780927 DOI: 10.1016/S1074-5521(00)00101-0 |
0.639 |
|
| 2000 |
Rotella DP, Mayer TU, Kapoor TM, Haggarty SJ, King RW, Schreiber SL, Mitchison TJ. Small-molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen Chemtracts. 13: 256-258. |
0.472 |
|
| 1999 |
King RW. Chemistry or biology: which comes first after the genome is sequenced? Chemistry & Biology. 6: R327-33. PMID 10631509 DOI: 10.1016/S1074-5521(00)80002-2 |
0.337 |
|
| 1999 |
Mayer TU, Kapoor TM, Haggarty SJ, King RW, Schreiber SL, Mitchison TJ. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science (New York, N.Y.). 286: 971-4. PMID 10542155 DOI: 10.1126/Science.286.5441.971 |
0.666 |
|
| 1998 |
Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. Science (New York, N.Y.). 279: 1219-22. PMID 9469815 DOI: 10.1126/Science.279.5354.1219 |
0.621 |
|
| 1997 |
Yamashita YM, Peters JM, King RW, Höög C, Kirschner MW, Zachariae W, Shin TH, Galova M, Obermaier B, Nasmyth K. BIME joins the destruction team. Trends in Cell Biology. 7: 49. PMID 17708905 DOI: 10.1016/S0962-8924(97)82669-4 |
0.345 |
|
| 1997 |
King RW, Lustig KD, Stukenberg PT, McGarry TJ, Kirschner MW. Expression cloning in the test tube. Science (New York, N.Y.). 277: 973-4. PMID 9281074 DOI: 10.1126/Science.277.5328.973 |
0.672 |
|
| 1997 |
Lustig KD, Stukenberg PT, McGarry TJ, King RW, Cryns VL, Mead PE, Zon LI, Yuan J, Kirschner MW. Small pool expression screening: identification of genes involved in cell cycle control, apoptosis, and early development. Methods in Enzymology. 283: 83-99. PMID 9251013 DOI: 10.1016/S0076-6879(97)83009-1 |
0.679 |
|
| 1997 |
Stukenberg PT, Lustig KD, McGarry TJ, King RW, Kuang J, Kirschner MW. Systematic identification of mitotic phosphoproteins. Current Biology : Cb. 7: 338-48. PMID 9115395 DOI: 10.1016/S0960-9822(06)00157-6 |
0.73 |
|
| 1996 |
King RW, Deshaies RJ, Peters JM, Kirschner MW. How proteolysis drives the cell cycle. Science (New York, N.Y.). 274: 1652-9. PMID 8939846 DOI: 10.1126/Science.274.5293.1652 |
0.726 |
|
| 1996 |
Peters JM, King RW, Höög C, Kirschner MW. Identification of BIME as a subunit of the anaphase-promoting complex. Science (New York, N.Y.). 274: 1199-201. PMID 8895470 DOI: 10.1126/Science.274.5290.1199 |
0.615 |
|
| 1996 |
King RW, Glotzer M, Kirschner MW. Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates. Molecular Biology of the Cell. 7: 1343-57. PMID 8885231 DOI: 10.1091/Mbc.7.9.1343 |
0.736 |
|
| 1996 |
Yu H, King RW, Peters JM, Kirschner MW. Identification of a novel ubiquitin-conjugating enzyme involved in mitotic cyclin degradation. Current Biology : Cb. 6: 455-66. PMID 8723350 DOI: 10.1016/S0960-9822(02)00513-4 |
0.584 |
|
| 1995 |
King RW, Peters JM, Tugendreich S, Rolfe M, Hieter P, Kirschner MW. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell. 81: 279-88. PMID 7736580 DOI: 10.1016/0092-8674(95)90338-0 |
0.645 |
|
| 1994 |
King RW, Jackson PK, Kirschner MW. Mitosis in transition. Cell. 79: 563-71. PMID 7954823 DOI: 10.1016/0092-8674(94)90542-8 |
0.549 |
|
| 1993 |
Holloway SL, Glotzer M, King RW, Murray AW. Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor. Cell. 73: 1393-402. PMID 8391932 DOI: 10.1016/0092-8674(93)90364-V |
0.723 |
|
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