Yoram Vodovotz - Publications

Affiliations: 
Computational and Systems Biology University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Biostatistics Biology, Bioinformatics Biology, Cell Biology

169 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Schimunek L, Lindberg H, Cohen M, Namas RA, Mi Q, Yin J, Barclay D, El-Dehaibi F, Abboud A, Zamora R, Billiar TR, Vodovotz Y. Computational Derivation of Core, Dynamic Human Blunt Trauma Inflammatory Endotypes. Frontiers in Immunology. 11: 589304. PMID 33537029 DOI: 10.3389/fimmu.2020.589304  0.4
2020 Vodovotz Y, Barclay D, Yin J, Squires RH, Zamora R. Dynamics of Systemic Inflammation as a Function of Developmental Stage in Pediatric Acute Liver Failure. Frontiers in Immunology. 11: 610861. PMID 33519820 DOI: 10.3389/fimmu.2020.610861  0.4
2020 Liu D, Namas RA, Vodovotz Y, Peitzman AB, Simmons RL, Yuan H, Mi Q, Billiar TR. Unsupervised Clustering Analysis Based on MODS Severity Identifies Four Distinct Organ Dysfunction Patterns in Severely Injured Blunt Trauma Patients. Frontiers in Medicine. 7: 46. PMID 32161760 DOI: 10.3389/fmed.2020.00046  0.4
2019 Zaaqoq AM, Namas RA, Abdul-Malak O, Almahmoud K, Barclay D, Yin J, Zamora R, Rosengart MR, Billiar TR, Vodovotz Y. Diurnal Variation in Systemic Acute Inflammation and Clinical Outcomes Following Severe Blunt Trauma. Frontiers in Immunology. 10: 2699. PMID 31824494 DOI: 10.3389/fimmu.2019.02699  0.4
2019 Schimunek L, Namas RA, Yin J, Barclay D, Liu D, El-Dehaibi F, Abboud A, Cohen M, Zamora R, Billiar TR, Vodovotz Y. Polymorphism Is Associated With Altered Systemic Inflammation and Adverse Trauma Outcomes. Frontiers in Genetics. 10: 1115. PMID 31781170 DOI: 10.3389/fgene.2019.01115  0.4
2019 Vodovotz Y, Simmons RL, Barclay D, Yin J, Jefferson BS, Zamora R. Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress . Annals of Translational Medicine. 7: 371. PMID 31555685 DOI: 10.21037/atm.2019.07.09  0.4
2019 Lamparello AJ, Namas RA, Schimunek L, Cohen M, El-Dehaibi F, Yin J, Barclay D, Zamora R, Billiar TR, Vodovotz Y. An Aging-Related Single-Nucleotide Polymorphism is Associated with Altered Clinical Outcomes and Distinct Inflammatory Profiles in Aged Blunt Trauma Patients. Shock (Augusta, Ga.). PMID 31318836 DOI: 10.1097/SHK.0000000000001411  0.4
2019 Vodovotz Y, An G. Agent-based models of inflammation in translational systems biology: A decade later. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. e1460. PMID 31260168 DOI: 10.1002/wsbm.1460  0.4
2019 Seymour CW, Kennedy JN, Wang S, Chang CH, Elliott CF, Xu Z, Berry S, Clermont G, Cooper G, Gomez H, Huang DT, Kellum JA, Mi Q, Opal SM, Talisa V, ... ... Vodovotz Y, et al. Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis. Jama. PMID 31104070 DOI: 10.1001/jama.2019.5791  0.4
2019 Toney NA, Bell MJ, Belle SH, Hardison RM, Rodriguez-Baez N, Loomes KM, Vodovotz Y, Zamora R, Squires RH. Hepatic Encephalopathy in Children with Acute Liver Failure - Utility of Serum Neuromarkers. Journal of Pediatric Gastroenterology and Nutrition. PMID 31058776 DOI: 10.1097/MPG.0000000000002351  0.4
2019 Zamora R, Barclay D, Yin J, Alonso EM, Leonis MA, Mi Q, Billiar TR, Simmons RL, Squires RH, Vodovotz Y. HMGB1 is a Central Driver of Dynamic Pro-inflammatory Networks in Pediatric Acute Liver Failure induced by Acetaminophen. Scientific Reports. 9: 5971. PMID 30979951 DOI: 10.1038/s41598-019-42564-5  0.4
2018 Day JD, Cockrell C, Namas R, Zamora R, An G, Vodovotz Y. Inflammation and Disease: Modelling and Modulation of the Inflammatory Response to Alleviate Critical Illness. Current Opinion in Systems Biology. 12: 22-29. PMID 30886940 DOI: 10.1016/j.coisb.2018.08.008  0.4
2018 Zamora R, Korff S, Mi Q, Barclay D, Schimunek L, Zucca R, Arsiwalla XD, Simmons RL, Verschure P, Billiar TR, Vodovotz Y. A computational analysis of dynamic, multi-organ inflammatory crosstalk induced by endotoxin in mice. Plos Computational Biology. 14: e1006582. PMID 30399158 DOI: 10.1371/journal.pcbi.1006582  0.4
2018 Sachdev U, Vodovotz L, Bitner J, Barclay D, Zamora R, Yin J, Simmons RL, Vodovotz Y. Suppressed networks of inflammatory mediators characterize chronic venous insufficiency. Journal of Vascular Surgery. Venous and Lymphatic Disorders. PMID 29439934 DOI: 10.1016/j.jvsv.2017.11.009  0.4
2017 Vodovotz Y, Simmons RL, Gandhi CR, Barclay D, Jefferson BS, Huang C, Namas R, El-Dehaibi F, Mi Q, Billiar TR, Zamora R. "Thinking" vs. "Talking": Differential Autocrine Inflammatory Networks in Isolated Primary Hepatic Stellate Cells and Hepatocytes under Hypoxic Stress. Frontiers in Physiology. 8: 1104. PMID 29312006 DOI: 10.3389/fphys.2017.01104  0.4
2017 Schimunek L, Namas RA, Yin J, Liu D, Barclay D, El-Dehaibi F, Abboud A, Lindberg H, Zamora R, Timothy RB, Vodovotz Y. An Enrichment Strategy Yields Seven Novel Single Nucleotide Polymorphisms Associated with Mortality and Altered TH17 Responses Following Blunt Trauma. Shock (Augusta, Ga.). PMID 28930911 DOI: 10.1097/SHK.0000000000000987  0.4
2016 Zamora R, Vodovotz Y, Mi Q, Barclay D, Yin J, Horslen S, Rudnick D, Loomes KM, Squires RH. Data-Driven Modeling for Precision Medicine in Pediatric Acute Liver Failure. Molecular Medicine (Cambridge, Mass.). 22. PMID 27900388 DOI: 10.2119/molmed.2016.00183  0.4
2016 Sadowsky D, Zamora R, Barclay D, Yin J, Fontes P, Vodovotz Y. Machine Perfusion of Porcine Livers with Oxygen-Carrying Solution Results in Reprogramming of Dynamic Inflammation Networks. Frontiers in Pharmacology. 7: 413. PMID 27867357 DOI: 10.3389/fphar.2016.00413  0.4
2016 Constantine G, Buliga M, Mi Q, Constantine F, Abboud A, Zamora R, Puccio A, Okonkwo D, Vodovotz Y. Dynamic Profiling: Modeling the Dynamics of Inflammation and Predicting Outcomes in Traumatic Brain Injury Patients. Frontiers in Pharmacology. 7: 383. PMID 27847476 DOI: 10.3389/fphar.2016.00383  0.4
2016 Abboud A, Mi Q, Puccio A, Okonkwo D, Buliga M, Constantine G, Vodovotz Y. Inflammation Following Traumatic Brain Injury in Humans: Insights from Data-Driven and Mechanistic Models into Survival and Death. Frontiers in Pharmacology. 7: 342. PMID 27729864 DOI: 10.3389/fphar.2016.00342  0.4
2016 Namas RA, Almahmoud K, Mi Q, Ghuma A, Namas R, Zaaqoq A, Zhu X, Abdul-Malak O, Sperry J, Zamora R, Billiar TR, Vodovotz Y. Individual-specific principal component analysis of circulating inflammatory mediators predicts early organ dysfunction in trauma patients. Journal of Critical Care. 36: 146-153. PMID 27546764 DOI: 10.1016/j.jcrc.2016.07.002  0.4
2016 Abboud A, Namas RA, Ramadan M, Mi Q, Almahmoud K, Abdul-Malak O, Azhar N, Zaaqoq A, Namas R, Barclay DA, Yin J, Sperry J, Peitzman A, Zamora R, Simmons RL, ... ... Vodovotz Y, et al. Computational Analysis Supports an Early, Type 17 Cell-Associated Divergence of Blunt Trauma Survival and Mortality. Critical Care Medicine. PMID 27513538 DOI: 10.1097/CCM.0000000000001951  1
2016 Kassab GS, An G, Sander EA, Miga MI, Guccione JM, Ji S, Vodovotz Y. Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective. Annals of Biomedical Engineering. PMID 27015816 DOI: 10.1007/s10439-016-1596-4  1
2015 Hussain F, Langmead CJ, Mi Q, Dutta-Moscato J, Vodovotz Y, Jha SK. Automated parameter estimation for biological models using Bayesian statistical model checking. Bmc Bioinformatics. 16: S8. PMID 26679759 DOI: 10.1186/1471-2105-16-S17-S8  0.4
2015 Starzl R, Wolfram D, Zamora R, Jefferson B, Barclay D, Ho C, Gorantla V, Brandacher G, Schneeberger S, Andrew Lee WP, Carbonell J, Vodovotz Y. Cardiac Arrest Disrupts Caspase-1 and Patterns of Inflammatory Mediators Differently in Skin and Muscle Following Localized Tissue Injury in Rats: Insights from Data-Driven Modeling. Frontiers in Immunology. 6: 587. PMID 26635801 DOI: 10.3389/fimmu.2015.00587  0.4
2015 Namas RA, Mi Q, Namas R, Almahmoud K, Zaaqoq A, Abdul-Malak O, Azhar N, Day J, Abboud A, Zamora R, Billiar T, Vodovotz Y. Insights into the Role of Chemokines, Damage-Associated Molecular Patterns, and Lymphocyte-derived Mediators from Computational Models of Trauma-Induced Inflammation. Antioxidants & Redox Signaling. PMID 26560096 DOI: 10.1089/ars.2015.6398  1
2015 Ziraldo C, Solovyev A, Allegretti A, Krishnan S, Henzel MK, Sowa GA, Brienza D, An G, Mi Q, Vodovotz Y. A Computational, Tissue-Realistic Model of Pressure Ulcer Formation in Individuals with Spinal Cord Injury. Plos Computational Biology. 11: e1004309. PMID 26111346 DOI: 10.1371/journal.pcbi.1004309  1
2015 Sadowsky D, Nieman G, Barclay D, Mi Q, Zamora R, Constantine G, Golub L, Lee HM, Roy S, Gatto LA, Vodovotz Y. Impact of chemically-modified tetracycline 3 on intertwined physiological, biochemical, and inflammatory networks in porcine sepsis/ARDS. International Journal of Burns and Trauma. 5: 22-35. PMID 26064799  0.4
2015 Vasudeva K, Vodovotz Y, Azhar N, Barclay D, Janjic JM, Pollock JA. In vivo and systems biology studies implicate IL-18 as a central mediator in chronic pain. Journal of Neuroimmunology. 283: 43-9. PMID 26004155 DOI: 10.1016/j.jneuroim.2015.04.012  1
2015 Brown D, Namas RA, Almahmoud K, Zaaqoq A, Sarkar J, Barclay DA, Yin J, Ghuma A, Abboud A, Constantine G, Nieman G, Zamora R, Chang SC, Billiar TR, Vodovotz Y. Trauma in silico: Individual-specific mathematical models and virtual clinical populations. Science Translational Medicine. 7: 285ra61. PMID 25925680 DOI: 10.1126/scitranslmed.aaa3636  1
2015 Nishikawa T, Bell A, Brooks JM, Setoyama K, Melis M, Han B, Fukumitsu K, Handa K, Tian J, Kaestner KH, Vodovotz Y, Locker J, Soto-Gutierrez A, Fox IJ. Resetting the transcription factor network reverses terminal chronic hepatic failure. The Journal of Clinical Investigation. 125: 1533-44. PMID 25774505 DOI: 10.1172/JCI73137  1
2015 Buchholz BM, Shapiro RA, Vodovotz Y, Billiar TR, Sodhi CP, Hackam DJ, Bauer AJ. Myocyte TLR4 enhances enteric and systemic inflammation driving late murine endotoxic ileus. American Journal of Physiology. Gastrointestinal and Liver Physiology. 308: G852-62. PMID 25747352 DOI: 10.1152/ajpgi.00211.2014  1
2015 Zolin SJ, Vodovotz Y, Forsythe RM, Rosengart MR, Namas R, Brown JB, Peitzman AP, Billiar TR, Sperry JL. The early evolving sex hormone environment is associated with significant outcome and inflammatory response differences after injury. The Journal of Trauma and Acute Care Surgery. 78: 451-7; discussion 45. PMID 25710413 DOI: 10.1097/TA.0000000000000550  1
2015 Wang J, Vodovotz Y, Fan L, Li Y, Liu Z, Namas R, Barclay D, Zamora R, Billiar TR, Wilson MA, Fan J, Jiang Y. Injury-induced MRP8/MRP14 stimulates IP-10/CXCL10 in monocytes/macrophages. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 250-62. PMID 25342131 DOI: 10.1096/fj.14-255992  1
2015 Wolf MT, Vodovotz Y, Tottey S, Brown BN, Badylak SF. Predicting in vivo responses to biomaterials via combined in vitro and in silico analysis. Tissue Engineering. Part C, Methods. 21: 148-59. PMID 24980950 DOI: 10.1089/ten.TEC.2014.0167  1
2014 Khalifian S, Nicholson Y, Ziraldo C, Starzl R, Schneeberger S, Thomson A, Brandacher G, Vodovotz Y, Raimondi G. Abstract 102: inflammatory mediators modulate alloreactive T cell susceptibility to immune-regulation in reconstructive transplantation. Plastic and Reconstructive Surgery. 133: 117. PMID 25942213 DOI: 10.1097/01.prs.0000444926.53453.9f  0.4
2014 Azhar N, Vodovotz Y. Innate immunity in disease: insights from mathematical modeling and analysis. Advances in Experimental Medicine and Biology. 844: 227-43. PMID 25480644 DOI: 10.1007/978-1-4939-2095-2_11  1
2014 Namas RA, Vodovotz Y, Almahmoud K, Abdul-Malak O, Zaaqoq A, Namas R, Mi Q, Barclay D, Zuckerbraun B, Peitzman AB, Sperry J, Billiar TR. Temporal Patterns of Circulating Inflammation Biomarker Networks Differentiate Susceptibility to Nosocomial Infection Following Blunt Trauma in Humans. Annals of Surgery. PMID 25371118 DOI: 10.1097/SLA.0000000000001001  1
2014 Dutta-Moscato J, Solovyev A, Mi Q, Nishikawa T, Soto-Gutierrez A, Fox IJ, Vodovotz Y. A Multiscale Agent-Based in silico Model of Liver Fibrosis Progression. Frontiers in Bioengineering and Biotechnology. 2: 18. PMID 25152891 DOI: 10.3389/fbioe.2014.00018  0.4
2014 Bielekova B, Vodovotz Y, An G, Hallenbeck J. How implementation of systems biology into clinical trials accelerates understanding of diseases. Frontiers in Neurology. 5: 102. PMID 25018747 DOI: 10.3389/fneur.2014.00102  0.4
2014 Wolfram D, Starzl R, Hackl H, Barclay D, Hautz T, Zelger B, Brandacher G, Lee WP, Eberhart N, Vodovotz Y, Pratschke J, Pierer G, Schneeberger S. Insights from computational modeling in inflammation and acute rejection in limb transplantation. Plos One. 9: e99926. PMID 24926998 DOI: 10.1371/journal.pone.0099926  0.4
2014 Mathew S, Bartels J, Banerjee I, Vodovotz Y. Global sensitivity analysis of a mathematical model of acute inflammation identifies nonlinear dependence of cumulative tissue damage on host interleukin-6 responses. Journal of Theoretical Biology. 358: 132-48. PMID 24909493 DOI: 10.1016/j.jtbi.2014.05.036  1
2014 Aerts JM, Haddad WM, An G, Vodovotz Y. From data patterns to mechanistic models in acute critical illness. Journal of Critical Care. 29: 604-10. PMID 24768566 DOI: 10.1016/j.jcrc.2014.03.018  1
2014 Zaaqoq AM, Namas R, Almahmoud K, Azhar N, Mi Q, Zamora R, Brienza DM, Billiar TR, Vodovotz Y. Inducible protein-10, a potential driver of neurally controlled interleukin-10 and morbidity in human blunt trauma. Critical Care Medicine. 42: 1487-97. PMID 24584064 DOI: 10.1097/CCM.0000000000000248  1
2014 Emr B, Sadowsky D, Azhar N, Gatto LA, An G, Nieman GF, Vodovotz Y. Removal of inflammatory ascites is associated with dynamic modification of local and systemic inflammation along with prevention of acute lung injury: in vivo and in silico studies. Shock (Augusta, Ga.). 41: 317-23. PMID 24430553 DOI: 10.1097/SHK.0000000000000121  1
2014 Huang W, Vodovotz Y, Kusturiss MB, Barclay D, Greenwald K, Boninger ML, Coen PM, Brienza D, Sowa G. Identification of distinct monocyte phenotypes and correlation with circulating cytokine profiles in acute response to spinal cord injury: a pilot study. Pm & R : the Journal of Injury, Function, and Rehabilitation. 6: 332-41. PMID 24140737 DOI: 10.1016/j.pmrj.2013.10.006  1
2014 Zhu X, Pribis JP, Rodriguez PC, Morris SM, Vodovotz Y, Billiar TR, Ochoa JB. The central role of arginine catabolism in T-cell dysfunction and increased susceptibility to infection after physical injury. Annals of Surgery. 259: 171-8. PMID 23470573 DOI: 10.1097/SLA.0b013e31828611f8  1
2013 Vodovotz Y, An G, Androulakis IP. A Systems Engineering Perspective on Homeostasis and Disease. Frontiers in Bioengineering and Biotechnology. 1: 6. PMID 25022216 DOI: 10.3389/fbioe.2013.00006  0.4
2013 Ziraldo C, Mi Q, An G, Vodovotz Y. Computational Modeling of Inflammation and Wound Healing. Advances in Wound Care. 2: 527-537. PMID 24527362 DOI: 10.1089/wound.2012.0416  0.4
2013 Ziraldo C, Vodovotz Y, Namas RA, Almahmoud K, Tapias V, Mi Q, Barclay D, Jefferson BS, Chen G, Billiar TR, Zamora R. Central role for MCP-1/CCL2 in injury-induced inflammation revealed by in vitro, in silico, and clinical studies. Plos One. 8: e79804. PMID 24312451 DOI: 10.1371/journal.pone.0079804  1
2013 Azhar N, Ziraldo C, Barclay D, Rudnick DA, Squires RH, Vodovotz Y. Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure Plos One. 8. PMID 24244295 DOI: 10.1371/journal.pone.0078202  1
2013 Emr B, Gatto LA, Roy S, Satalin J, Ghosh A, Snyder K, Andrews P, Habashi N, Marx W, Ge L, Wang G, Dean DA, Vodovotz Y, Nieman G. Airway pressure release ventilation prevents ventilator-induced lung injury in normal lungs. Jama Surgery. 148: 1005-12. PMID 24026214 DOI: 10.1001/jamasurg.2013.3746  1
2013 Namas RA, Bartels J, Hoffman R, Barclay D, Billiar TR, Zamora R, Vodovotz Y. Combined in silico, in vivo, and in vitro studies shed insights into the acute inflammatory response in middle-aged mice. Plos One. 8: e67419. PMID 23844008 DOI: 10.1371/journal.pone.0067419  0.4
2013 Price I, Ermentrout B, Zamora R, Wang B, Azhar N, Mi Q, Constantine G, Faeder JR, Luckhart S, Vodovotz Y. In vivo, in vitro, and in silico studies suggest a conserved immune module that regulates malaria parasite transmission from mammals to mosquitoes. Journal of Theoretical Biology. 334: 173-86. PMID 23764028 DOI: 10.1016/j.jtbi.2013.05.028  1
2013 Solovyev A, Mi Q, Tzen YT, Brienza D, Vodovotz Y. Hybrid equation/agent-based model of ischemia-induced hyperemia and pressure ulcer formation predicts greater propensity to ulcerate in subjects with spinal cord injury. Plos Computational Biology. 9: e1003070. PMID 23696726 DOI: 10.1371/journal.pcbi.1003070  1
2013 Christley S, Emr B, Ghosh A, Satalin J, Gatto L, Vodovotz Y, Nieman GF, An G. Bayesian inference of the lung alveolar spatial model for the identification of alveolar mechanics associated with acute respiratory distress syndrome. Physical Biology. 10: 036008. PMID 23598859 DOI: 10.1088/1478-3975/10/3/036008  1
2013 Roy S, Habashi N, Sadowitz B, Andrews P, Ge L, Wang G, Roy P, Ghosh A, Kuhn M, Satalin J, Gatto LA, Lin X, Dean DA, Vodovotz Y, Nieman G. Early airway pressure release ventilation prevents ARDS-a novel preventive approach to lung injury. Shock (Augusta, Ga.). 39: 28-38. PMID 23247119 DOI: 10.1097/SHK.0b013e31827b47bb  1
2013 Arciero J, Bard Ermentrout G, Siggers R, Afrazi A, Hackam D, Vodovotz Y, Rubin J. Modeling the interactions of bacteria and Toll-like receptor-mediated inflammation in necrotizing enterocolitis Journal of Theoretical Biology. 321: 83-99. PMID 23238281 DOI: 10.1016/j.jtbi.2012.12.002  1
2013 Barber J, Tronzo M, Harold Horvat C, Clermont G, Upperman J, Vodovotz Y, Yotov I. A three-dimensional mathematical and computational model of necrotizing enterocolitis. Journal of Theoretical Biology. 322: 17-32. PMID 23228363 DOI: 10.1016/j.jtbi.2012.11.018  1
2013 Zhang M, Ueki S, Kimura S, Yoshida O, Castellaneta A, Ozaki KS, Demetris AJ, Ross M, Vodovotz Y, Thomson AW, B Stolz D, Geller DA, Murase N. Roles of dendritic cells in murine hepatic warm and liver transplantation-induced cold ischemia/reperfusion injury. Hepatology (Baltimore, Md.). 57: 1585-96. PMID 23184590 DOI: 10.1002/hep.26129  1
2013 Scheff JD, Mavroudis PD, Foteinou PT, An G, Calvano SE, Doyle J, Dick TE, Lowry SF, Vodovotz Y, Androulakis IP. A multiscale modeling approach to inflammation: A case study in human endotoxemia Journal of Computational Physics. 244: 279-289. DOI: 10.1016/j.jcp.2012.09.024  1
2013 Azhar N, Mi Q, Ziraldo C, Buliga M, Constantine GM, Vodovotz Y. Integrating data-driven and mechanistic models of the inflammatory response in sepsis and trauma Complex Systems and Computational Biology Approaches to Acute Inflammation. 143-157. DOI: 10.1007/978-1-4614-8008-2_8  1
2013 An G, Vodovotz Y. The rationale and implementation of translational systems biology as a new paradigm for the study of inflammation Complex Systems and Computational Biology Approaches to Acute Inflammation. 283-287. DOI: 10.1007/978-1-4614-8008-2_15  1
2013 Stern JR, Ziraldo C, Vodovotz Y, An G. Agent-based models of wound healing Complex Systems and Computational Biology Approaches to Acute Inflammation. 209-228. DOI: 10.1007/978-1-4614-8008-2_12  1
2012 Namas RA, Mikheev M, Yin J, Over P, Young M, Constantine GM, Zamora R, Gerlach J, Vodovotz Y. A Biohybrid Device for the Systemic Control of Acute Inflammation. Disruptive Science and Technology. 1. PMID 24205448 DOI: 10.1089/dst.2012.0001  0.4
2012 An G, Namas RA, Vodovotz Y. Sepsis: from pattern to mechanism and back. Critical Reviews in Biomedical Engineering. 40: 341-51. PMID 23140124  0.4
2012 Vodovotz Y, Prelich J, Lagoa C, Barclay D, Zamora R, Murase N, Gandhi CR. Augmenter of liver regeneration (ALR) is a novel biomarker of hepatocellular stress/inflammation: in vitro, in vivo and in silico studies. Molecular Medicine (Cambridge, Mass.). 18: 1421-9. PMID 23073658 DOI: 10.2119/molmed.2012.00183  1
2012 Sumpter TL, Dangi A, Matta BM, Huang C, Stolz DB, Vodovotz Y, Thomson AW, Gandhi CR. Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO. Journal of Immunology (Baltimore, Md. : 1950). 189: 3848-58. PMID 22962681 DOI: 10.4049/jimmunol.1200819  1
2012 An G, Nieman G, Vodovotz Y. Computational and systems biology in trauma and sepsis: current state and future perspectives. International Journal of Burns and Trauma. 2: 1-10. PMID 22928162  0.4
2012 Roy S, Sadowitz B, Andrews P, Gatto LA, Marx W, Ge L, Wang G, Lin X, Dean DA, Kuhn M, Ghosh A, Satalin J, Snyder K, Vodovotz Y, Nieman G, et al. Early stabilizing alveolar ventilation prevents acute respiratory distress syndrome: a novel timing-based ventilatory intervention to avert lung injury. The Journal of Trauma and Acute Care Surgery. 73: 391-400. PMID 22846945 DOI: 10.1097/TA.0b013e31825c7a82  1
2012 Zamora R, Azhar N, Namas R, Metukuri MR, Clermont T, Gladstone C, Namas RA, Hermus L, Megas C, Constantine G, Billiar TR, Fink MP, Vodovotz Y. Identification of a novel pathway of transforming growth factor-β1 regulation by extracellular NAD+ in mouse macrophages: in vitro and in silico studies. The Journal of Biological Chemistry. 287: 31003-14. PMID 22829588 DOI: 10.1074/jbc.M112.344309  1
2012 Dick TE, Molkov YI, Nieman G, Hsieh YH, Jacono FJ, Doyle J, Scheff JD, Calvano SE, Androulakis IP, An G, Vodovotz Y. Linking Inflammation, Cardiorespiratory Variability, and Neural Control in Acute Inflammation via Computational Modeling. Frontiers in Physiology. 3: 222. PMID 22783197 DOI: 10.3389/fphys.2012.00222  1
2012 Namas RA, Namas R, Lagoa C, Barclay D, Mi Q, Zamora R, Peng Z, Wen X, Fedorchak MV, Valenti IE, Federspiel WJ, Kellum JA, Vodovotz Y. Hemoadsorption reprograms inflammation in experimental gram-negative septic peritonitis: insights from in vivo and in silico studies. Molecular Medicine (Cambridge, Mass.). 18: 1366-74. PMID 22751621 DOI: 10.2119/molmed.2012.00106  1
2012 An G, Nieman G, Vodovotz Y. Toward computational identification of multiscale "tipping points" in acute inflammation and multiple organ failure. Annals of Biomedical Engineering. 40: 2414-24. PMID 22527009 DOI: 10.1007/s10439-012-0565-9  0.4
2012 Sperry JL, Vodovotz Y, Ferrell RE, Namas R, Chai YM, Feng QM, Jia WP, Forsythe RM, Peitzman AB, Billiar TR. Racial disparities and sex-based outcomes differences after severe injury. Journal of the American College of Surgeons. 214: 973-80. PMID 22521668 DOI: 10.1016/j.jamcollsurg.2012.02.020  1
2012 Dangi A, Sumpter TL, Kimura S, Stolz DB, Murase N, Raimondi G, Vodovotz Y, Huang C, Thomson AW, Gandhi CR. Selective expansion of allogeneic regulatory T cells by hepatic stellate cells: role of endotoxin and implications for allograft tolerance. Journal of Immunology (Baltimore, Md. : 1950). 188: 3667-77. PMID 22427640 DOI: 10.4049/jimmunol.1102460  1
2012 Nieman G, Brown D, Sarkar J, Kubiak B, Ziraldo C, Dutta-Moscato J, Vieau C, Barclay D, Gatto L, Maier K, Constantine G, Billiar TR, Zamora R, Mi Q, Chang S, ... Vodovotz Y, et al. A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine. Critical Care Medicine. 40: 1052-63. PMID 22425816 DOI: 10.1097/CCM.0b013e31823e986a  0.4
2012 Weber M, Lambeck S, Ding N, Henken S, Kohl M, Deigner HP, Enot DP, Igwe EI, Frappart L, Kiehntopf M, Claus RA, Kamradt T, Weih D, Vodovotz Y, Briles DE, et al. Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 2424-36. PMID 22415311 DOI: 10.1096/fj.11-191957  1
2012 Lee JS, Sperry JL, Ochoa JB, Barclay D, Namas R, Vodovotz Y, Rosengart MR. Persistence of elevated plasma CXCL8 concentrations following red blood cell transfusion in a trauma cohort. Shock (Augusta, Ga.). 37: 373-7. PMID 22293598 DOI: 10.1097/SHK.0b013e31824bcb72  0.4
2012 Liu L, Yannam GR, Nishikawa T, Yamamoto T, Basma H, Ito R, Nagaya M, Dutta-Moscato J, Stolz DB, Duan F, Kaestner KH, Vodovotz Y, Soto-Gutierrez A, Fox IJ. The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis. Hepatology (Baltimore, Md.). 55: 1529-39. PMID 22109844 DOI: 10.1002/hep.24815  1
2012 Namas R, Zamora R, Namas R, An G, Doyle J, Dick TE, Jacono FJ, Androulakis IP, Nieman GF, Chang S, Billiar TR, Kellum JA, Angus DC, Vodovotz Y. Sepsis: Something old, something new, and a systems view. Journal of Critical Care. 27: 314.e1-11. PMID 21798705 DOI: 10.1016/j.jcrc.2011.05.025  0.4
2011 Li NY, Vodovotz Y, Kim KH, Mi Q, Hebda PA, Abbott KV. Biosimulation of acute phonotrauma: an extended model. The Laryngoscope. 121: 2418-28. PMID 22020892 DOI: 10.1002/lary.22226  1
2011 Edmonds RD, Vodovotz Y, Lagoa C, Dutta-Moscato J, Yang Y, Fink MP, Levy RM, Prince JM, Kaczorowski DJ, Tseng GC, Billiar TR. Transcriptomic response of murine liver to severe injury and hemorrhagic shock: a dual-platform microarray analysis. Physiological Genomics. 43: 1170-83. PMID 21828244 DOI: 10.1152/physiolgenomics.00020.2011  1
2011 Ramsgaard L, Englert JM, Manni ML, Milutinovic PS, Gefter J, Tobolewski J, Crum L, Coudriet GM, Piganelli J, Zamora R, Vodovotz Y, Enghild JJ, Oury TD. Lack of the receptor for advanced glycation end-products attenuates e. coli pneumonia in mice Plos One. 6. PMID 21629785 DOI: 10.1371/journal.pone.0020132  1
2011 Mi Q, Constantine G, Ziraldo C, Solovyev A, Torres A, Namas R, Bentley T, Billiar TR, Zamora R, Puyana JC, Vodovotz Y. A dynamic view of trauma/hemorrhage-induced inflammation in mice: principal drivers and networks. Plos One. 6: e19424. PMID 21573002 DOI: 10.1371/journal.pone.0019424  0.4
2011 Namas RA, Metukuri MR, Dhupar R, Velosa C, Jefferson BS, Myer E, Constantine GM, Billiar TR, Vodovotz Y, Zamora R. Hypoxia-induced overexpression of BNIP3 is not dependent on hypoxia-inducible factor 1α in mouse hepatocytes. Shock (Augusta, Ga.). 36: 196-202. PMID 21558981 DOI: 10.1097/SHK.0b013e3182205e07  1
2011 An G, Bartels J, Vodovotz Y. In Silico Augmentation of the Drug Development Pipeline: Examples from the study of Acute Inflammation. Drug Development Research. 72: 187-200. PMID 21552346 DOI: 10.1002/ddr.20415  0.4
2011 Brown BN, Price IM, Toapanta FR, DeAlmeida DR, Wiley CA, Ross TM, Oury TD, Vodovotz Y. An agent-based model of inflammation and fibrosis following particulate exposure in the lung. Mathematical Biosciences. 231: 186-96. PMID 21385589 DOI: 10.1016/j.mbs.2011.03.005  1
2011 Menzel CL, Pfeifer R, Darwiche SS, Kobbe P, Gill R, Shapiro RA, Loughran P, Vodovotz Y, Scott MJ, Zenati MS, Billiar TR, Pape HC. Models of lower extremity damage in mice: time course of organ damage and immune response. The Journal of Surgical Research. 166: e149-56. PMID 21276982 DOI: 10.1016/j.jss.2010.11.914  1
2010 Constantine GM, Buliga M, Vodovotz Y, Bohnen NI. TWO AUTOCOVARIANCE-BASED MEASURES OF BALANCE IN PARKINSONIANS AND NORMAL CONTROLS. International Journal of Pure and Applied Mathematics : Ijpam. 63: 269-278. PMID 28845122  0.4
2010 Solovyev A, Mikheev M, Zhou L, Dutta-Moscato J, Ziraldo C, An G, Vodovotz Y, Mi Q. SPARK: A Framework for Multi-Scale Agent-Based Biomedical Modeling. International Journal of Agent Technologies and Systems. 2: 18-30. PMID 24163721 DOI: 10.4018/jats.2010070102  0.4
2010 Mi Q, Li NY, Ziraldo C, Ghuma A, Mikheev M, Squires R, Okonkwo DO, Verdolini-Abbott K, Constantine G, An G, Vodovotz Y. Translational systems biology of inflammation: potential applications to personalized medicine. Personalized Medicine. 7: 549-559. PMID 21339856 DOI: 10.2217/pme.10.45  1
2010 Vodovotz Y, An G. Systems biology and inflammation. Methods in Molecular Biology (Clifton, N.J.). 662: 181-201. PMID 20824472 DOI: 10.1007/978-1-60761-800-3_9  1
2010 Arciero JC, Ermentrout GB, Upperman JS, Vodovotz Y, Rubin JE. Using a mathematical model to analyze the role of probiotics and inflammation in necrotizing enterocolitis. Plos One. 5: e10066. PMID 20419099 DOI: 10.1371/journal.pone.0010066  1
2010 Vodovotz Y, Constantine G, Faeder J, Mi Q, Rubin J, Bartels J, Sarkar J, Squires RH, Okonkwo DO, Gerlach J, Zamora R, Luckhart S, Ermentrout B, An G. Translational systems approaches to the biology of inflammation and healing. Immunopharmacology and Immunotoxicology. 32: 181-95. PMID 20170421 DOI: 10.3109/08923970903369867  1
2010 Martins-Green M, Vodovotz Y, Liu P. Systems biology applied to wound healing. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 18: 1-2. PMID 20082673 DOI: 10.1111/j.1524-475X.2009.00567.x  1
2010 Li NY, Abbott KV, Rosen C, An G, Hebda PA, Vodovotz Y. Translational systems biology and voice pathophysiology. The Laryngoscope. 120: 511-5. PMID 20025041 DOI: 10.1002/lary.20755  1
2010 Raimondi G, Sumpter TL, Matta BM, Pillai M, Corbitt N, Vodovotz Y, Wang Z, Thomson AW. Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients. Journal of Immunology (Baltimore, Md. : 1950). 184: 624-36. PMID 20007530 DOI: 10.4049/jimmunol.0900936  1
2010 Prince JM, Vodovotz Y, Baun MJ, Monga SP, Billiar TR, Gerlach JC. The nitric oxide donor S-nitrosoglutathione reduces apoptotic primary liver cell loss in a three-dimensional perfusion bioreactor culture model developed for liver support. Tissue Engineering. Part A. 16: 861-6. PMID 19814591 DOI: 10.1089/ten.TEA.2009.0256  1
2010 Tyagi P, Barclay D, Zamora R, Yoshimura N, Peters K, Vodovotz Y, Chancellor M. Urine cytokines suggest an inflammatory response in the overactive bladder: a pilot study. International Urology and Nephrology. 42: 629-35. PMID 19784793 DOI: 10.1007/s11255-009-9647-5  0.4
2010 Loughran PA, Bagci EZ, Zamora R, Vodovotz Y, Billiar TR. The Role of Nitric Oxide in Apoptosis and Autophagy. Biochemical and Computational Studies Nitric Oxide. 513-537. DOI: 10.1016/B978-0-12-373866-0.00015-0  1
2009 Namas R, Ghuma A, Hermus L, Zamora R, Okonkwo DO, Billiar TR, Vodovotz Y. The acute inflammatory response in trauma / hemorrhage and traumatic brain injury: current state and emerging prospects. The Libyan Journal of Medicine. 4: 97-103. PMID 21483522 DOI: 10.4176/090325  1
2009 An G, Mi Q, Dutta-Moscato J, Vodovotz Y. Agent-based models in translational systems biology. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 1: 159-71. PMID 20835989 DOI: 10.1002/wsbm.45  0.4
2009 Namas R, Ghuma A, Torres A, Polanco P, Gomez H, Barclay D, Gordon L, Zenker S, Kim HK, Hermus L, Zamora R, Rosengart MR, Clermont G, Peitzman A, Billiar TR, ... ... Vodovotz Y, et al. An adequately robust early TNF-alpha response is a hallmark of survival following trauma/hemorrhage. Plos One. 4: e8406. PMID 20027315 DOI: 10.1371/journal.pone.0008406  0.4
2009 Tyagi P, Tyagi V, Yoshimura N, Witteemer E, Barclay D, Loughran PA, Zamora R, Vodovotz Y. Gender-based reciprocal expression of transforming growth factor-beta1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis. Journal of Inflammation (London, England). 6: 23. PMID 19691848 DOI: 10.1186/1476-9255-6-23  0.4
2009 Metukuri MR, Namas R, Gladstone C, Clermont T, Jefferson B, Barclay D, Hermus L, Billiar TR, Zamora R, Vodovotz Y. Activation of latent transforming growth factor-beta1 by nitric oxide in macrophages: role of soluble guanylate cyclase and MAP kinases. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 17: 578-88. PMID 19614923 DOI: 10.1111/j.1524-475X.2009.00509.x  1
2009 Wognum S, Lagoa CE, Nagatomi J, Sacks MS, Vodovotz Y. An exploratory pathways analysis of temporal changes induced by spinal cord injury in the rat bladder wall: insights on remodeling and inflammation. Plos One. 4: e5852. PMID 19513121 DOI: 10.1371/journal.pone.0005852  1
2009 Metukuri MR, Beer-Stolz D, Namas RA, Dhupar R, Torres A, Loughran PA, Jefferson BS, Tsung A, Billiar TR, Vodovotz Y, Zamora R. Expression and subcellular localization of BNIP3 in hypoxic hepatocytes and liver stress. American Journal of Physiology. Gastrointestinal and Liver Physiology. 296: G499-509. PMID 19147804 DOI: 10.1152/ajpgi.90526.2008  1
2009 Torres A, Bentley T, Bartels J, Sarkar J, Barclay D, Namas R, Constantine G, Zamora R, Puyana JC, Vodovotz Y. Mathematical modeling of posthemorrhage inflammation in mice: studies using a novel, computer-controlled, closed-loop hemorrhage apparatus. Shock (Augusta, Ga.). 32: 172-8. PMID 19008782 DOI: 10.1097/SHK.0b013e318193cc2b  0.4
2009 Rivière B, Epshteyn Y, Swigon D, Vodovotz Y. A simple mathematical model of signaling resulting from the binding of lipopolysaccharide with Toll-like receptor 4 demonstrates inherent preconditioning behavior. Mathematical Biosciences. 217: 19-26. PMID 18950647 DOI: 10.1016/j.mbs.2008.10.002  1
2009 Smaldone MC, Vodovotz Y, Tyagi V, Barclay D, Philips BJ, Yoshimura N, Chancellor MB, Tyagi P. Multiplex analysis of urinary cytokine levels in rat model of cyclophosphamide-induced cystitis. Urology. 73: 421-6. PMID 18848347 DOI: 10.1016/j.urology.2008.07.031  1
2009 Vodovotz Y, Constantine G, Rubin J, Csete M, Voit EO, An G. Mechanistic simulations of inflammation: current state and future prospects. Mathematical Biosciences. 217: 1-10. PMID 18835282 DOI: 10.1016/j.mbs.2008.07.013  1
2009 Constantine GM, Bartels J, Chow CC, Clermont G, Vodovotz Y. A linear code parameter search algorithm with applications to immunology Computational Optimization and Applications. 42: 155-171. DOI: 10.1007/s10589-007-9118-9  1
2008 Daun S, Rubin J, Vodovotz Y, Clermont G. Equation-based models of dynamic biological systems Journal of Critical Care. 23: 585-594. PMID 19056027 DOI: 10.1016/j.jcrc.2008.02.003  1
2008 Li NY, Verdolini K, Clermont G, Mi Q, Rubinstein EN, Hebda PA, Vodovotz Y. A patient-specific in silico model of inflammation and healing tested in acute vocal fold injury. Plos One. 3: e2789. PMID 18665229 DOI: 10.1371/journal.pone.0002789  0.4
2008 Barclay D, Zamora R, Torres A, Namas R, Steed D, Vodovotz Y. A simple, rapid, and convenient Luminex-compatible method of tissue isolation. Journal of Clinical Laboratory Analysis. 22: 278-81. PMID 18623112 DOI: 10.1002/jcla.20253  0.4
2008 Kobbe P, Vodovotz Y, Kaczorowski DJ, Mollen KP, Billiar TR, Pape HC. Patterns of cytokine release and evolution of remote organ dysfunction after bilateral femur fracture. Shock (Augusta, Ga.). 30: 43-7. PMID 18562923 DOI: 10.1097/SHK.0b013e31815d190b  1
2008 Daun S, Rubin J, Vodovotz Y, Roy A, Parker R, Clermont G. An ensemble of models of the acute inflammatory response to bacterial lipopolysaccharide in rats: Results from parameter space reduction Journal of Theoretical Biology. 253: 843-853. PMID 18550083 DOI: 10.1016/j.jtbi.2008.04.033  1
2008 Bagci EZ, Vodovotz Y, Billiar TR, Ermentrout B, Bahar I. Computational insights on the competing effects of nitric oxide in regulating apoptosis. Plos One. 3: e2249. PMID 18509469 DOI: 10.1371/journal.pone.0002249  1
2008 Kobbe P, Kaczorowski DJ, Vodovotz Y, Tzioupis CH, Mollen KP, Billiar TR, Pape HC. Local exposure of bone components to injured soft tissue induces Toll-like receptor 4-dependent systemic inflammation with acute lung injury. Shock (Augusta, Ga.). 30: 686-91. PMID 18461022 DOI: 10.1097/SHK.0b013e31816f257e  1
2008 Vodovotz Y, Csete M, Bartels J, Chang S, An G. Translational systems biology of inflammation. Plos Computational Biology. 4: e1000014. PMID 18437239 DOI: 10.1371/journal.pcbi.1000014  0.4
2008 An G, Faeder J, Vodovotz Y. Translational systems biology: Introduction of an engineering approach to the pathophysiology of the burn patient Journal of Burn Care and Research. 29: 277-285. PMID 18354282 DOI: 10.1097/BCR.0b013e31816677c8  1
2008 Mollen KP, Levy RM, Prince JM, Hoffman RA, Scott MJ, Kaczorowski DJ, Vallabhaneni R, Vodovotz Y, Billiar TR. Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells. Journal of Leukocyte Biology. 83: 80-8. PMID 17925504 DOI: 10.1189/jlb.0407201  1
2007 Mi Q, Rivière B, Clermont G, Steed DL, Vodovotz Y. Agent-based model of inflammation and wound healing: insights into diabetic foot ulcer pathology and the role of transforming growth factor-beta1. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 15: 671-82. PMID 17971013 DOI: 10.1111/j.1524-475X.2007.00271.x  0.4
2007 Mi Q, Swigon D, Rivière B, Cetin S, Vodovotz Y, Hackam DJ. One-dimensional elastic continuum model of enterocyte layer migration. Biophysical Journal. 93: 3745-52. PMID 17704181 DOI: 10.1529/biophysj.107.112326  1
2007 Levy RM, Mollen KP, Prince JM, Kaczorowski DJ, Vallabhaneni R, Liu S, Tracey KJ, Lotze MT, Hackam DJ, Fink MP, Vodovotz Y, Billiar TR. Systemic inflammation and remote organ injury following trauma require HMGB1. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 293: R1538-44. PMID 17652366 DOI: 10.1152/ajpregu.00272.2007  1
2007 An G, Hunt CA, Clermont G, Neugebauer E, Vodovotz Y. Challenges and rewards on the road to translational systems biology in acute illness: four case reports from interdisciplinary teams Journal of Critical Care. 22: 169-175. PMID 17548029 DOI: 10.1016/j.jcrc.2006.12.011  1
2007 Fan J, Li Y, Levy RM, Fan JJ, Hackam DJ, Vodovotz Y, Yang H, Tracey KJ, Billiar TR, Wilson MA. Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling. Journal of Immunology (Baltimore, Md. : 1950). 178: 6573-80. PMID 17475888  1
2007 Vodovotz Y, Clermont G, Hunt CA, Lefering R, Bartels J, Seydel R, Hotchkiss J, Ta'asan S, Neugebauer E, An G. Evidence-based modeling of critical illness: an initial consensus from the Society for Complexity in Acute Illness. Journal of Critical Care. 22: 77-84. PMID 17371750 DOI: 10.1016/j.jcrc.2006.12.001  1
2007 Upperman JS, Camerini V, Lugo B, Yotov I, Sullivan J, Rubin J, Rubin J, Clermont G, Zamora R, Ermentrout GB, Ford HR, Vodovotz Y. Mathematical modeling in necrotizing enterocolitis--a new look at an ongoing problem. Journal of Pediatric Surgery. 42: 445-53. PMID 17336179 DOI: 10.1016/j.jpedsurg.2006.10.053  1
2007 Prince JM, Ming MJ, Levy RM, Liu S, Pinsky DJ, Vodovotz Y, Billiar TR. Early growth response 1 mediates the systemic and hepatic inflammatory response initiated by hemorrhagic shock. Shock (Augusta, Ga.). 27: 157-64. PMID 17224790 DOI: 10.1097/01.shk.0000245025.01365.8e  1
2006 Lagoa CE, Bartels J, Baratt A, Tseng G, Clermont G, Fink MP, Billiar TR, Vodovotz Y. The role of initial trauma in the host's response to injury and hemorrhage: insights from a correlation of mathematical simulations and hepatic transcriptomic analysis. Shock (Augusta, Ga.). 26: 592-600. PMID 17117135 DOI: 10.1097/01.shk.0000232272.03602.0a  1
2006 Prince JM, Levy RM, Bartels J, Baratt A, Kane JM, Lagoa C, Rubin J, Day J, Wei J, Fink MP, Goyert SM, Clermont G, Billiar TR, Vodovotz Y. In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice. Molecular Medicine (Cambridge, Mass.). 12: 88-96. PMID 16953560 DOI: 10.2119/2006-00012.Prince  1
2006 Vodovotz Y, Chow CC, Bartels J, Lagoa C, Prince JM, Levy RM, Kumar R, Day J, Rubin J, Constantine G, Billiar TR, Fink MP, Clermont G. In silico models of acute inflammation in animals. Shock (Augusta, Ga.). 26: 235-44. PMID 16912648 DOI: 10.1097/01.shk.0000225413.13866.fo  1
2006 Levy RM, Prince JM, Yang R, Mollen KP, Liao H, Watson GA, Fink MP, Vodovotz Y, Billiar TR. Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 291: R970-6. PMID 16675630 DOI: 10.1152/ajpregu.00793.2005  1
2006 Day J, Rubin J, Vodovotz Y, Chow CC, Reynolds A, Clermont G. A reduced mathematical model of the acute inflammatory response II. Capturing scenarios of repeated endotoxin administration. Journal of Theoretical Biology. 242: 237-56. PMID 16616206 DOI: 10.1016/j.jtbi.2006.02.015  1
2006 Reynolds A, Rubin J, Clermont G, Day J, Vodovotz Y, Bard Ermentrout G. A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation Journal of Theoretical Biology. 242: 220-236. PMID 16584750 DOI: 10.1016/j.jtbi.2006.02.016  1
2006 Wang Y, Kim PKM, Peng X, Loughran P, Vodovotz Y, Zhang B, Billiar TR. Cyclic AMP and Cyclic GMP suppress TNFα-induced hepatocyte apoptosis by inhibiting FADD up-regulation via a protein kinase A-dependent pathway Apoptosis. 11: 441-451. PMID 16538385 DOI: 10.1007/s10495-005-4293-6  1
2006 Prince JM, Levy RM, Yang R, Mollen KP, Fink MP, Vodovotz Y, Billiar TR. Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock. Journal of the American College of Surgeons. 202: 407-17. PMID 16500244 DOI: 10.1016/j.jamcollsurg.2005.11.021  1
2006 Bagci EZ, Vodovotz Y, Billiar TR, Ermentrout GB, Bahar I. Bistability in apoptosis: roles of bax, bcl-2, and mitochondrial permeability transition pores. Biophysical Journal. 90: 1546-59. PMID 16339882 DOI: 10.1529/biophysj.105.068122  1
2005 Nathan C, Calingasan N, Nezezon J, Ding A, Lucia MS, La Perle K, Fuortes M, Lin M, Ehrt S, Kwon NS, Chen J, Vodovotz Y, Kipiani K, Beal MF. Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase. The Journal of Experimental Medicine. 202: 1163-9. PMID 16260491 DOI: 10.1084/jem.20051529  1
2005 Loughran PA, Stolz DB, Vodovotz Y, Watkins SC, Simmons RL, Billiar TR. Monomeric inducible nitric oxide synthase localizes to peroxisomes in hepatocytes. Proceedings of the National Academy of Sciences of the United States of America. 102: 13837-42. PMID 16172396 DOI: 10.1073/pnas.0503926102  1
2005 Lagoa CE, Vodovotz Y, Stolz DB, Lhuillier F, McCloskey C, Gallo D, Yang R, Ustinova E, Fink MP, Billiar TR, Mars WM. The role of hepatic type 1 plasminogen activator inhibitor (PAI-1) during murine hemorrhagic shock Hepatology. 42: 390-399. PMID 16025510 DOI: 10.1002/hep.20797  1
2005 Zamora R, Vodovotz Y, Betten B, Wong C, Zuckerbraun B, Gibson KF, Ford HR. Intestinal and hepatic expression of BNIP3 in necrotizing enterocolitis: regulation by nitric oxide and peroxynitrite. American Journal of Physiology. Gastrointestinal and Liver Physiology. 289: G822-30. PMID 16002567 DOI: 10.1152/ajpgi.00181.2005  1
2005 Chow CC, Clermont G, Kumar R, Lagoa C, Tawadrous Z, Gallo D, Betten B, Bartels J, Constantine G, Fink MP, Billiar TR, Vodovotz Y. The acute inflammatory response in diverse shock states. Shock (Augusta, Ga.). 24: 74-84. PMID 15988324 DOI: 10.1097/01.shk.0000168526.97716.f3  1
2004 Vodovotz Y, Kim PK, Bagci EZ, Ermentrout GB, Chow CC, Bahar I, Billiar TR. Inflammatory modulation of hepatocyte apoptosis by nitric oxide: in vivo, in vitro, and in silico studies. Current Molecular Medicine. 4: 753-62. PMID 15579022 DOI: 10.2174/1566524043359944  1
2004 Clermont G, Bartels J, Kumar R, Constantine G, Vodovotz Y, Chow C. In silico design of clinical trials: a method coming of age. Critical Care Medicine. 32: 2061-70. PMID 15483415 DOI: 10.1097/01.CCM.0000142394.28791.C3  1
2004 Vodovotz Y, Clermont G, Chow C, An G. Mathematical models of the acute inflammatory response Current Opinion in Critical Care. 10: 383-390. PMID 15385756 DOI: 10.1097/01.ccx.0000139360.30327.69  1
2004 Kumar R, Clermont G, Vodovotz Y, Chow CC. The dynamics of acute inflammation. Journal of Theoretical Biology. 230: 145-55. PMID 15321710 DOI: 10.1016/j.jtbi.2004.04.044  1
2004 Kim PKM, Zuckerbraun BS, Otterbein LE, Vodovotz Y, Billiar TR. 'Til cell death do us part: Nitric oxide and mechanisms of hepatotoxicity Biological Chemistry. 385: 11-15. PMID 14977041 DOI: 10.1515/BC.2004.002  1
2003 Luckhart S, Crampton AL, Zamora R, Lieber MJ, Dos Santos PC, Peterson TM, Emmith N, Lim J, Wink DA, Vodovotz Y. Mammalian transforming growth factor beta1 activated after ingestion by Anopheles stephensi modulates mosquito immunity. Infection and Immunity. 71: 3000-9. PMID 12761076 DOI: 10.1128/IAI.71.6.3000-3009.2003  1
2002 Zamora R, Vodovotz Y, Aulak KS, Kim PKM, Kane JM, Alarcon L, Stuehr DJ, Billiar TR. A DNA microarray study of nitric oxide-induced genes in mouse hepatocytes: Implications for hepatic heme oxygenase-1 expression in ischemia/reperfusion Nitric Oxide - Biology and Chemistry. 7: 165-186. PMID 12381414 DOI: 10.1016/S1089-8603(02)00104-0  1
2002 Stolz DB, Zamora R, Vodovotz Y, Loughran PA, Billiar TR, Kim YM, Simmons RL, Watkins SC. Peroxisomal localization of inducible nitric oxide synthase in hepatocytes. Hepatology (Baltimore, Md.). 36: 81-93. PMID 12085352 DOI: 10.1053/jhep.2002.33716  1
2002 Wang Y, Vodovotz Y, Kim PKM, Zamora R, Billiar TR. Mechanisms of hepatoprotection by nitric oxide Annals of the New York Academy of Sciences. 962: 415-422. PMID 12076992 DOI: 10.1111/j.1749-6632.2002.tb04085.x  1
2002 Liu S, Gallo DJ, Green AM, Williams DL, Gong X, Shapiro RA, Gambotto AA, Humphris EL, Vodovotz Y, Billiar TR. Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide. Infection and Immunity. 70: 3433-42. PMID 12065483 DOI: 10.1128/IAI.70.7.3433-3442.2002  1
2001 Zamora R, Alarcon L, Vodovotz Y, Betten B, Kim PKM, Gibson KF, Billiar TR. Nitric Oxide Suppresses the Expression of Bcl-2 Binding Protein BNIP3 in Hepatocytes Journal of Biological Chemistry. 276: 46887-46895. PMID 11592958 DOI: 10.1074/jbc.M101865200  1
2001 Zamora R, Vodovotz Y, Alarcon L, Betten B, Loughran PA, Aulak KS, Stuehr DJ, Gibson KF, Billiar TR. Nitric oxide from the inducible nitric oxide synthase (iNOS) increases the expression of cytochrome P450 2E1 in iNOS-null hepatocytes in the absence of inflammatory stimuli Archives of Biochemistry and Biophysics. 390: 287-294. PMID 11396931 DOI: 10.1006/abbi.2001.2391  1
2000 Liu S, Salyapongse AN, Geller DA, Vodovotz Y, Billiar TR. Hepatocyte Toll-Like Receptor 2 expression in vivo and in vitro: Role of cytokines in induction of rat TLR2 gene expression by lipopolysaccharide Shock. 14: 361-365. PMID 11028557 DOI: 10.1097/00024382-200014030-00021  1
1999 Vodovotz Y, Coffin D, DeLuca AM, McKinney L, Cook JA, Wink D, Mitchell JB. Induction of nitric oxide production in infiltrating leukocytes following in vivo irradiation of tumor-bearing mice. Radiation Oncology Investigations. 7: 86-97. PMID 10333249 DOI: 10.1002/(SICI)1520-6823(1999)7:2<86::AID-ROI4>3.0.CO;2-L  1
1999 Jourd'heuil D, Miranda KM, Kim SM, Espey MG, Vodovotz Y, Laroux S, Mai CT, Miles AM, Grisham MB, Wink DA. The oxidative and nitrosative chemistry of the nitric oxide/superoxide reaction in the presence of bicarbonate. Archives of Biochemistry and Biophysics. 365: 92-100. PMID 10222043 DOI: 10.1006/abbi.1999.1143  1
1999 Chong H, Vodovotz Y, Cox GW, Barcellos-Hoff MH. Immunocytochemical localization of latent transforming growth factor-beta1 activation by stimulated macrophages. Journal of Cellular Physiology. 178: 275-83. PMID 9989773 DOI: 10.1002/(SICI)1097-4652(199903)178:3<275::AID-JCP1>3.0.CO;2-Q  1
1999 Wink DA, Kim S, Coffin D, Cook JC, Vodovotz Y, Chistodoulou D, Jourd'heuil D, Grisham MB. Detection of S-nitrosothiols by fluorometric and colorimetric methods. Methods in Enzymology. 301: 201-11. PMID 9919568 DOI: 10.1016/S0076-6879(99)01083-6  1
1998 Wink DA, Feelisch M, Fukuto J, Chistodoulou D, Jourd'heuil D, Grisham MB, Vodovotz Y, Cook JA, Krishna M, DeGraff WG, Kim S, Gamson J, Mitchell JB. The cytotoxicity of nitroxyl: Possible implications for the pathophysiological role of NO Archives of Biochemistry and Biophysics. 351: 66-74. PMID 9501920 DOI: 10.1006/abbi.1997.0565  1
1997 Wink DA, Cook JA, Christodoulou D, Krishna MC, Pacelli R, Kim S, Degraff W, Gamson J, Vodovotz Y, Russo A, Mitchell JB. Nitric oxide and some nitric oxide donor compounds enhance the cytotoxicity of cisplatin Nitric Oxide - Biology and Chemistry. 1: 88-94. PMID 9701048 DOI: 10.1006/niox.1996.0108  1
1997 Vodovotz Y, Hsing A, Cook JA, Miller RW, Wink DA, Ritt DM, Mitchell JB, Danielpour D. Qualitative and quantitative analysis of DNA fragmentation using digital imaging Analytical Biochemistry. 250: 147-152. PMID 9245431 DOI: 10.1006/abio.1997.2226  1
1997 Wink DA, Cook JA, Kim SY, Vodovotz Y, Pacelli R, Krishna MC, Russo A, Mitchell JB, Jourd'heuil D, Miles AM, Grisham MB. Superoxide modulates the oxidation and nitrosation of thiols by nitric oxide-derived reactive intermediates. Chemical aspects involved in the balance between oxidative and nitrosative stress Journal of Biological Chemistry. 272: 11147-11151. PMID 9111012 DOI: 10.1074/jbc.272.17.11147  1
1994 Sparrow JR, Nathan C, Vodovotz Y. Cytokine regulation of nitric oxide synthase in mouse retinal pigment epithelial cells in culture Experimental Eye Research. 59: 129-139. PMID 7530664 DOI: 10.1006/exer.1994.1091  1
1992 Roberts AB, Vodovotz Y, Roche NS, Sporn MB, Nathan CF. Role of nitric oxide in antagonistic effects of transforming growth factor-beta and interleukin-1 beta on the beating rate of cultured cardiac myocytes. Molecular Endocrinology (Baltimore, Md.). 6: 1921-30. PMID 1282674 DOI: 10.1210/mend.6.11.1282674  1
1991 Bogdan C, Vodovotz Y, Nathan C. Macrophage deactivation by interleukin 10. The Journal of Experimental Medicine. 174: 1549-55. PMID 1744584 DOI: 10.1084/JEM.174.6.1549  1
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