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Howard J Worman, M.D. - Publications

Affiliations: 
Columbia University College of Physicians and Surgeons, New York, NY, United States 
Area:
Lamins, Inner nuclear membrane proteins
Website:
http://asp.cpmc.columbia.edu/facdb/profile_list.asp?uni=hjw14&DepAffil=Medicine

149 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Hernandez-Ono A, Zhao YP, Murray JW, Östlund C, Lee MJ, Shi A, Dauer WT, Worman HJ, Ginsberg HN, Shin JY. Functional interaction of torsinA and its activators in liver lipid metabolism. Biorxiv : the Preprint Server For Biology. PMID 37547008 DOI: 10.1101/2023.06.21.545957  0.581
2022 Östlund C, Hernandez-Ono A, Turk SJ, Dauer WT, Ginsberg HN, Worman HJ, Shin JY. Hepatocytes deficient in nuclear envelope protein lamina-associated polypeptide 1 are an ideal mammalian system to study intranuclear lipid droplets. Journal of Lipid Research. 100277. PMID 36100089 DOI: 10.1016/j.jlr.2022.100277  0.632
2022 Wang Y, Shilagardi K, Hsu T, Odinammadu KO, Maruyama T, Wu W, Lin CS, Damoci CB, Spear ED, Shin JY, Hsu W, Michaelis S, Worman HJ. Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35197292 DOI: 10.1073/pnas.2118695119  0.615
2021 Shin JY, Worman HJ. Molecular Pathology of Laminopathies. Annual Review of Pathology. PMID 34672689 DOI: 10.1146/annurev-pathol-042220-034240  0.679
2021 Vignier N, Chatzifrangkeskou M, Pinton L, Wioland H, Marais T, Lemaitre M, Le Dour C, Peccate C, Cardoso D, Schmitt A, Wu W, Biferi MG, Naouar N, Macquart C, Beuvin M, ... ... Worman HJ, et al. The non-muscle ADF/cofilin-1 controls sarcomeric actin filament integrity and force production in striated muscle laminopathies. Cell Reports. 36: 109601. PMID 34433058 DOI: 10.1016/j.celrep.2021.109601  0.647
2021 Kronenberg-Tenga R, Tatli M, Eibauer M, Wu W, Shin JY, Bonne G, Worman HJ, Medalia O. A lamin A/C variant causing striated muscle disease provides insights into filament organization. Journal of Cell Science. PMID 33536248 DOI: 10.1242/jcs.256156  0.659
2021 Dridi H, Wu W, Reiken SR, Ofer RM, Liu Y, Yuan Q, Sittenfeld L, Kushner J, Muchir A, Worman HJ, Marks AR. Ryanodine receptor remodeling in cardiomyopathy and muscular dystrophy caused by lamin A/C gene mutation. Human Molecular Genetics. PMID 33388782 DOI: 10.1093/hmg/ddaa278  0.689
2020 Marcelot A, Worman HJ, Zinn-Justin S. Protein structural and mechanistic basis of progeroid laminopathies. The Febs Journal. PMID 32799420 DOI: 10.1111/Febs.15526  0.453
2020 Lindenboim L, Zohar H, Worman HJ, Stein R. The nuclear envelope: target and mediator of the apoptotic process. Cell Death Discovery. 6: 29. PMID 32351716 DOI: 10.1038/S41420-020-0256-5  0.319
2019 Antoku S, Wu W, Joseph LC, Morrow JP, Worman HJ, Gundersen GG. ERK1/2 Phosphorylation of FHOD Connects Signaling and Nuclear Positioning Alternations in Cardiac Laminopathy. Developmental Cell. 51: 602-616.e12. PMID 31794718 DOI: 10.1016/J.Devcel.2019.10.023  0.501
2019 Muchir A, Worman HJ. Emery-Dreifuss muscular dystrophy: focal point nuclear envelope. Current Opinion in Neurology. 32: 728-734. PMID 31460960 DOI: 10.1097/Wco.0000000000000741  0.683
2019 Shin JY, Hernandez-Ono A, Fedotova T, Östlund C, Lee MJ, Gibeley SB, Liang CC, Dauer WT, Ginsberg HN, Worman HJ. Nuclear envelope-localized torsinA-LAP1 complex regulates hepatic VLDL secretion and steatosis. The Journal of Clinical Investigation. 130. PMID 31408437 DOI: 10.1172/Jci129769  0.631
2019 Östlund C, Chang W, Gundersen GG, Worman HJ. Pathogenic mutations in genes encoding nuclear envelope proteins and defective nucleocytoplasmic connections. Experimental Biology and Medicine (Maywood, N.J.). 1535370219862243. PMID 31299860 DOI: 10.1177/1535370219862243  0.457
2019 Wang Y, Shin JY, Nakanishi K, Homma S, Kim GJ, Tanji K, Joseph LC, Morrow JP, Stewart CL, Dauer WT, Worman HJ. Postnatal Development of Mice with Combined Genetic Depletions of Lamin A/C, Emerin and Lamina-associated Polypeptide 1. Human Molecular Genetics. PMID 31009944 DOI: 10.1093/Hmg/Ddz082  0.678
2019 Chang W, Wang Y, Luxton GWG, Östlund C, Worman HJ, Gundersen GG. Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging. Proceedings of the National Academy of Sciences of the United States of America. 116: 3578-3583. PMID 30808750 DOI: 10.1073/Pnas.1809683116  0.348
2018 Nagy PL, Worman HJ. Next-Generation Sequencing and Mutational Analysis: Implications for Genes Encoding LINC Complex Proteins. Methods in Molecular Biology (Clifton, N.J.). 1840: 321-336. PMID 30141054 DOI: 10.1007/978-1-4939-8691-0_22  0.308
2018 Worman HJ, Michaelis S. Permanently Farnesylated Prelamin A, Progeria, and Atherosclerosis. Circulation. 138: 283-286. PMID 30012702 DOI: 10.1161/Circulationaha.118.034480  0.409
2018 Chatzifrangkeskou M, Yadin D, Marais T, Chardonnet S, Cohen-Tannoudji M, Mougenot N, Schmitt A, Crasto S, Di Pasquale E, Macquart C, Tanguy Y, Jebeniani I, Pucéat M, Morales Rodriguez B, Goldmann WH, ... ... Worman HJ, et al. Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation. Human Molecular Genetics. PMID 29878125 DOI: 10.1093/Hmg/Ddy215  0.702
2018 Choi JC, Wu W, Phillips E, Plevin R, Sera F, Homma S, Worman HJ. Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival. Human Molecular Genetics. PMID 29668927 DOI: 10.1093/Hmg/Ddy134  0.7
2017 Worman HJ. Cell signaling abnormalities in cardiomyopathy caused by lamin A/C gene mutations. Biochemical Society Transactions. PMID 29196611 DOI: 10.1042/Bst20170236  0.52
2017 Le Dour C, Macquart C, Sera F, Homma S, Bonne G, Morrow JP, Worman HJ, Muchir A. Decreased WNT/β-catenin signalling contributes to the pathogenesis of dilated cardiomyopathy caused by mutations in the lamin a/C gene. Human Molecular Genetics. PMID 28069793 DOI: 10.1093/Hmg/Ddw389  0.672
2016 Wu W, Chordia MD, Hart BP, Kumarasinghe ES, Ji MK, Bhargava A, Lawlor MW, Shin JY, Sera F, Homma S, Muchir A, Khire UR, Worman HJ. Macrocyclic MEK1/2 inhibitor with efficacy in a mouse model of cardiomyopathy caused by lamin A/C gene mutation. Bioorganic & Medicinal Chemistry. PMID 28011205 DOI: 10.1016/J.Bmc.2016.12.014  0.785
2016 Le Dour C, Wu W, Béréziat V, Capeau J, Vigouroux C, Worman HJ. Extracellular Matrix Remodeling and Transforming Growth Factor-β Signaling Abnormalities Induced by Lamin A/C Variants that Cause Lipodystrophy. Journal of Lipid Research. PMID 27845687 DOI: 10.1194/Jlr.M071381  0.388
2016 Shin JY, Méndez-López I, Hong M, Wang Y, Tanji K, Wu W, Shugol L, Krauss RS, Dauer WT, Worman HJ. Lamina-associated polypeptide 1 is dispensable for embryonic myogenesis but required for postnatal skeletal muscle growth. Human Molecular Genetics. PMID 27798115 DOI: 10.1093/Hmg/Ddw368  0.652
2016 Chatzifrangkeskou M, Le Dour C, Wu W, Morrow JP, Joseph LC, Beuvin M, Sera F, Homma S, Vignier N, Mougenot N, Bonne G, Lipson KE, Worman HJ, Muchir A. ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C gene. Human Molecular Genetics. PMID 27131347 DOI: 10.1093/Hmg/Ddw090  0.685
2016 Wang Y, Lichter-Konecki U, Anyane-Yeboa K, Shaw JE, Lu JT, Östlund C, Shin JY, Clark LN, Gundersen GG, Nagy PL, Worman HJ. Mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder. Journal of Cell Science. PMID 27034136 DOI: 10.1242/Jcs.187302  0.662
2016 Wu W, Patel A, Kyöstilä K, Lohi H, Mladkova N, Kiryluk K, Sun X, Lefkowitch JH, Worman HJ, Gharavi AG. Genome-wide Association Study in Mice Identifies Loci Affecting Liver-related Phenotypes Including Sel1l Influencing Serum Bile Acids. Hepatology (Baltimore, Md.). PMID 26857093 DOI: 10.1002/Hep.28495  0.315
2016 Muchir A, Worman HJ. Targeting Mitogen-Activated Protein Kinase Signaling in Mouse Models of Cardiomyopathy Caused by Lamin A/C Gene Mutations. Methods in Enzymology. 568: 557-80. PMID 26795484 DOI: 10.1016/Bs.Mie.2015.07.028  0.724
2015 Herrada I, Samson C, Velours C, Renault L, Östlund C, Chervy P, Puchkov D, Worman HJ, Buendia B, Zinn-Justin S. Muscular Dystrophy Mutations Impair the Nuclear Envelope Emerin Self-assembly Properties. Acs Chemical Biology. PMID 26415001 DOI: 10.1021/Acschembio.5B00648  0.39
2015 Worman HJ, Schirmer EC. Nuclear membrane diversity: underlying tissue-specific pathologies in disease? Current Opinion in Cell Biology. 34: 101-12. PMID 26115475 DOI: 10.1016/J.Ceb.2015.06.003  0.392
2015 Chang W, Antoku S, Östlund C, Worman HJ, Gundersen GG. Linker of nucleoskeleton and cytoskeleton (LINC) complex-mediated actin-dependent nuclear positioning orients centrosomes in migrating myoblasts. Nucleus (Austin, Tex.). 6: 77-88. PMID 25587885 DOI: 10.1080/19491034.2015.1004947  0.331
2015 Chang W, Worman HJ, Gundersen GG. Accessorizing and anchoring the LINC complex for multifunctionality. The Journal of Cell Biology. 208: 11-22. PMID 25559183 DOI: 10.1083/Jcb.201409047  0.304
2014 Lindenboim L, Sasson T, Worman HJ, Borner C, Stein R. Cellular stress induces Bax-regulated nuclear bubble budding and rupture followed by nuclear protein release. Nucleus (Austin, Tex.). 5: 527-41. PMID 25482068 DOI: 10.4161/19491034.2014.970105  0.364
2014 Muchir A, Wu W, Sera F, Homma S, Worman HJ. Mitogen-activated protein kinase kinase 1/2 inhibition and angiotensin II converting inhibition in mice with cardiomyopathy caused by lamin A/C gene mutation. Biochemical and Biophysical Research Communications. 452: 958-61. PMID 25218145 DOI: 10.1016/J.Bbrc.2014.09.020  0.709
2014 Meinke P, Mattioli E, Haque F, Antoku S, Columbaro M, Straatman KR, Worman HJ, Gundersen GG, Lattanzi G, Wehnert M, Shackleton S. Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organization. Plos Genetics. 10: e1004605. PMID 25210889 DOI: 10.1371/Journal.Pgen.1004605  0.46
2014 Worman HJ, Dauer WT. The nuclear envelope: an intriguing focal point for neurogenetic disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 11: 764-72. PMID 25119890 DOI: 10.1007/S13311-014-0296-8  0.409
2014 Shin JY, Le Dour C, Sera F, Iwata S, Homma S, Joseph LC, Morrow JP, Dauer WT, Worman HJ. Depletion of lamina-associated polypeptide 1 from cardiomyocytes causes cardiac dysfunction in mice. Nucleus (Austin, Tex.). 5: 260-459. PMID 24859316 DOI: 10.4161/Nucl.29227  0.687
2014 Choi JC, Worman HJ. Nuclear envelope regulation of signaling cascades. Advances in Experimental Medicine and Biology. 773: 187-206. PMID 24563349 DOI: 10.1007/978-1-4899-8032-8_9  0.641
2014 Shin JY, Dauer WT, Worman HJ. Lamina-associated polypeptide 1: protein interactions and tissue-selective functions. Seminars in Cell & Developmental Biology. 29: 164-8. PMID 24508913 DOI: 10.1016/J.Semcdb.2014.01.010  0.701
2014 Wu W, Iwata S, Homma S, Worman HJ, Muchir A. Depletion of extracellular signal-regulated kinase 1 in mice with cardiomyopathy caused by lamin A/C gene mutation partially prevents pathology before isoenzyme activation. Human Molecular Genetics. 23: 1-11. PMID 23933734 DOI: 10.1093/Hmg/Ddt387  0.723
2013 Shin JY, Méndez-López I, Wang Y, Hays AP, Tanji K, Lefkowitch JH, Schulze PC, Worman HJ, Dauer WT. Lamina-associated polypeptide-1 interacts with the muscular dystrophy protein emerin and is essential for skeletal muscle maintenance. Developmental Cell. 26: 591-603. PMID 24055652 DOI: 10.1016/J.Devcel.2013.08.012  0.661
2013 Muchir A, Kim YJ, Reilly SA, Wu W, Choi JC, Worman HJ. Inhibition of extracellular signal-regulated kinase 1/2 signaling has beneficial effects on skeletal muscle in a mouse model of Emery-Dreifuss muscular dystrophy caused by lamin A/C gene mutation. Skeletal Muscle. 3: 17. PMID 23815988 DOI: 10.1186/2044-5040-3-17  0.758
2013 Bourgeois B, Gilquin B, Tellier-Lebègue C, Östlund C, Wu W, Pérez J, El Hage P, Lallemand F, Worman HJ, Zinn-Justin S. Inhibition of TGF-β signaling at the nuclear envelope: characterization of interactions between MAN1, Smad2 and Smad3, and PPM1A. Science Signaling. 6: ra49. PMID 23779087 DOI: 10.1126/Scisignal.2003411  0.363
2013 Worman HJ, Segil N. Nucleocytoplasmic connections and deafness. The Journal of Clinical Investigation. 123: 553-5. PMID 23348730 DOI: 10.1172/Jci67454  0.403
2013 Singh M, Hunt CR, Pandita RK, Kumar R, Yang CR, Horikoshi N, Bachoo R, Serag S, Story MD, Shay JW, Powell SN, Gupta A, Jeffery J, Pandita S, Chen BP, ... ... Worman HJ, et al. Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest. Molecular and Cellular Biology. 33: 1210-22. PMID 23319047 DOI: 10.1128/Mcb.01676-12  0.325
2013 Choi JC, Worman HJ. Reactivation of autophagy ameliorates LMNA cardiomyopathy. Autophagy. 9: 110-1. PMID 23044536 DOI: 10.4161/Auto.22403  0.676
2013 Kamradt M, Zou C, Liu L, Wang Y, Fitchev PP, Worman HJ, Crawford SE, Talamonti M, Gao Q. Abstract 331: Head and neck and skin squamous cell carcinoma developed in a BRCA2 knockout mouse model. Cancer Research. 73: 331-331. DOI: 10.1158/1538-7445.Am2013-331  0.302
2012 Choi JC, Wu W, Muchir A, Iwata S, Homma S, Worman HJ. Dual specificity phosphatase 4 mediates cardiomyopathy caused by lamin A/C (LMNA) gene mutation. The Journal of Biological Chemistry. 287: 40513-24. PMID 23048029 DOI: 10.1074/Jbc.M112.404541  0.791
2012 Frock RL, Chen SC, Da DF, Frett E, Lau C, Brown C, Pak DN, Wang Y, Muchir A, Worman HJ, Santana LF, Ladiges WC, Rabinovitch PS, Kennedy BK. Cardiomyocyte-specific expression of lamin a improves cardiac function in Lmna-/- mice. Plos One. 7: e42918. PMID 22905185 DOI: 10.1371/Journal.Pone.0042918  0.662
2012 Wang Y, Ostlund C, Choi JC, Swayne TC, Gundersen GG, Worman HJ. Blocking farnesylation of the prelamin A variant in Hutchinson-Gilford progeria syndrome alters the distribution of A-type lamins. Nucleus (Austin, Tex.). 3: 452-62. PMID 22895092 DOI: 10.4161/Nucl.21675  0.627
2012 Choi JC, Muchir A, Wu W, Iwata S, Homma S, Morrow JP, Worman HJ. Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation. Science Translational Medicine. 4: 144ra102. PMID 22837537 DOI: 10.1126/Scitranslmed.3003875  0.777
2012 Muchir A, Wu W, Choi JC, Iwata S, Morrow J, Homma S, Worman HJ. Abnormal p38α mitogen-activated protein kinase signaling in dilated cardiomyopathy caused by lamin A/C gene mutation. Human Molecular Genetics. 21: 4325-33. PMID 22773734 DOI: 10.1093/Hmg/Dds265  0.784
2012 Duarte-Rey C, Bogdanos D, Yang CY, Roberts K, Leung PS, Anaya JM, Worman HJ, Gershwin ME. Primary biliary cirrhosis and the nuclear pore complex. Autoimmunity Reviews. 11: 898-902. PMID 22487189 DOI: 10.1016/J.Autrev.2012.03.005  0.344
2012 Méndez-López I, Worman HJ. Inner nuclear membrane proteins: impact on human disease. Chromosoma. 121: 153-67. PMID 22307332 DOI: 10.1007/S00412-012-0360-2  0.456
2012 Attur M, Ben-Artzi A, Yang Q, Al-Mussawir HE, Worman HJ, Palmer G, Abramson SB. Perturbation of nuclear lamin A causes cell death in chondrocytes. Arthritis and Rheumatism. 64: 1940-9. PMID 22231515 DOI: 10.1002/Art.34360  0.358
2012 Muchir A, Reilly SA, Wu W, Iwata S, Homma S, Bonne G, Worman HJ. Treatment with selumetinib preserves cardiac function and improves survival in cardiomyopathy caused by mutation in the lamin A/C gene. Cardiovascular Research. 93: 311-9. PMID 22068161 DOI: 10.1093/Cvr/Cvr301  0.708
2012 Worman HJ. Nuclear lamins and laminopathies. The Journal of Pathology. 226: 316-25. PMID 21953297 DOI: 10.1002/Path.2999  0.472
2012 Frock RL, Chen SC, Dai D, Frett E, Lau C, Brown C, Pak DN, Wang Y, Muchir A, Worman HJ, Santana LF, Ladiges WC, Rabinovitch PS, Kennedy BK. Correction: Cardiomyocyte-Specific Expression of Lamin A Improves Cardiac Function in Lmna−/−Mice Plos One. 7. DOI: 10.1371/Annotation/92Be6B32-D8E7-44C2-80A9-21097Ad27965  0.622
2011 Duband-Goulet I, Woerner S, Gasparini S, Attanda W, Kondé E, Tellier-Lebègue C, Craescu CT, Gombault A, Roussel P, Vadrot N, Vicart P, Ostlund C, Worman HJ, Zinn-Justin S, Buendia B. Subcellular localization of SREBP1 depends on its interaction with the C-terminal region of wild-type and disease related A-type lamins. Experimental Cell Research. 317: 2800-13. PMID 21993218 DOI: 10.1016/J.Yexcr.2011.09.012  0.43
2011 Luxton GW, Gomes ER, Folker ES, Worman HJ, Gundersen GG. TAN lines: a novel nuclear envelope structure involved in nuclear positioning. Nucleus (Austin, Tex.). 2: 173-81. PMID 21818410 DOI: 10.4161/Nucl.2.3.16243  0.314
2011 Lu JT, Muchir A, Nagy PL, Worman HJ. LMNA cardiomyopathy: cell biology and genetics meet clinical medicine. Disease Models & Mechanisms. 4: 562-8. PMID 21810905 DOI: 10.1242/Dmm.006346  0.692
2011 Wu W, Muchir A, Shan J, Bonne G, Worman HJ. Mitogen-activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by mutation in lamin A/C gene. Circulation. 123: 53-61. PMID 21173351 DOI: 10.1161/Circulationaha.110.970673  0.728
2011 Folker ES, Ostlund C, Luxton GW, Worman HJ, Gundersen GG. Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement. Proceedings of the National Academy of Sciences of the United States of America. 108: 131-6. PMID 21173262 DOI: 10.1073/Pnas.1000824108  0.429
2010 Muchir A, Wu W, Worman HJ. Mitogen-activated protein kinase inhibitor regulation of heart function and fibrosis in cardiomyopathy caused by lamin A/C gene mutation. Trends in Cardiovascular Medicine. 20: 217-21. PMID 22293021 DOI: 10.1016/J.Tcm.2011.11.002  0.728
2010 Wang Y, Ostlund C, Worman HJ. Blocking protein farnesylation improves nuclear shape abnormalities in keratinocytes of mice expressing the prelamin A variant in Hutchinson-Gilford progeria syndrome. Nucleus (Austin, Tex.). 1: 432-9. PMID 21326826 DOI: 10.4161/Nucl.1.5.12972  0.44
2010 Muchir A, Worman HJ. Signaling defects and the nuclear envelope in progeria. Developmental Cell. 19: 355-6. PMID 20833355 DOI: 10.1016/J.Devcel.2010.08.019  0.654
2010 Kondé E, Bourgeois B, Tellier-Lebegue C, Wu W, Pérez J, Caputo S, Attanda W, Gasparini S, Charbonnier JB, Gilquin B, Worman HJ, Zinn-Justin S. Structural analysis of the Smad2-MAN1 interaction that regulates transforming growth factor-β signaling at the inner nuclear membrane. Biochemistry. 49: 8020-32. PMID 20715792 DOI: 10.1021/Bi101153W  0.349
2010 Bruston F, Delbarre E, Ostlund C, Worman HJ, Buendia B, Duband-Goulet I. Loss of a DNA binding site within the tail of prelamin A contributes to altered heterochromatin anchorage by progerin. Febs Letters. 584: 2999-3004. PMID 20580717 DOI: 10.1016/J.Febslet.2010.05.032  0.344
2010 Marji J, O'Donoghue SI, McClintock D, Satagopam VP, Schneider R, Ratner D, Worman HJ, Gordon LB, Djabali K. Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition. Plos One. 5: e11132. PMID 20559568 DOI: 10.1371/Journal.Pone.0011132  0.454
2010 Wu W, Shan J, Bonne G, Worman HJ, Muchir A. Pharmacological inhibition of c-Jun N-terminal kinase signaling prevents cardiomyopathy caused by mutation in LMNA gene. Biochimica Et Biophysica Acta. 1802: 632-8. PMID 20388542 DOI: 10.1016/J.Bbadis.2010.04.001  0.731
2010 Worman HJ, Ostlund C, Wang Y. Diseases of the nuclear envelope. Cold Spring Harbor Perspectives in Biology. 2: a000760. PMID 20182615 DOI: 10.1101/Cshperspect.A000760  0.438
2010 Worman HJ, Foisner R. The nuclear envelope from basic biology to therapy. Biochemical Society Transactions. 38: 253-6. PMID 20074069 DOI: 10.1042/Bst0380253  0.387
2010 Worman HJ. Prelamin A prenylation and the treatment of progeria. Journal of Lipid Research. 51: 223-5. PMID 19965579 DOI: 10.1194/Jlr.E004366  0.44
2009 Dauer WT, Worman HJ. The nuclear envelope as a signaling node in development and disease. Developmental Cell. 17: 626-38. PMID 19922868 DOI: 10.1016/J.Devcel.2009.10.016  0.426
2009 Ostlund C, Folker ES, Choi JC, Gomes ER, Gundersen GG, Worman HJ. Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins. Journal of Cell Science. 122: 4099-108. PMID 19843581 DOI: 10.1242/Jcs.057075  0.576
2009 Ostlund C, Guan T, Figlewicz DA, Hays AP, Worman HJ, Gerace L, Schirmer EC. Reduction of a 4q35-encoded nuclear envelope protein in muscle differentiation. Biochemical and Biophysical Research Communications. 389: 279-83. PMID 19716805 DOI: 10.1016/J.Bbrc.2009.08.133  0.616
2009 Worman HJ, Fong LG, Muchir A, Young SG. Laminopathies and the long strange trip from basic cell biology to therapy. The Journal of Clinical Investigation. 119: 1825-36. PMID 19587457 DOI: 10.1172/Jci37679  0.691
2009 Verstraeten VL, Caputo S, van Steensel MA, Duband-Goulet I, Zinn-Justin S, Kamps M, Kuijpers HJ, Ostlund C, Worman HJ, Briedé JJ, Le Dour C, Marcelis CL, van Geel M, Steijlen PM, van den Wijngaard A, et al. The R439C mutation in LMNA causes lamin oligomerization and susceptibility to oxidative stress. Journal of Cellular and Molecular Medicine. 13: 959-71. PMID 19220582 DOI: 10.1111/J.1582-4934.2009.00690.X  0.371
2009 Muchir A, Wu W, Worman HJ. Reduced expression of A-type lamins and emerin activates extracellular signal-regulated kinase in cultured cells. Biochimica Et Biophysica Acta. 1792: 75-81. PMID 19022376 DOI: 10.1016/J.Bbadis.2008.10.012  0.707
2009 Muchir A, Shan J, Bonne G, Lehnart SE, Worman HJ. Inhibition of extracellular signal-regulated kinase signaling to prevent cardiomyopathy caused by mutation in the gene encoding A-type lamins. Human Molecular Genetics. 18: 241-7. PMID 18927124 DOI: 10.1093/Hmg/Ddn343  0.729
2009 Muchir A, Wu W, Shan J, Bonne G, Worman H. G.P.15.06 Inhibition of c-Jun N-terminal kinases signaling to prevent cardiomyopathy caused by mutation in LMNA gene Neuromuscular Disorders. 19: 648-649. DOI: 10.1016/J.Nmd.2009.06.325  0.681
2008 Wang Y, Panteleyev AA, Owens DM, Djabali K, Stewart CL, Worman HJ. Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin. Human Molecular Genetics. 17: 2357-69. PMID 18442998 DOI: 10.1093/Hmg/Ddn136  0.394
2007 Worman HJ. Nuclear envelope protein autoantigens in primary biliary cirrhosis. Hepatology Research : the Official Journal of the Japan Society of Hepatology. 37: S406-11. PMID 17931195 DOI: 10.1111/J.1872-034X.2007.00227.X  0.309
2007 Lüdtke A, Buettner J, Schmidt HH, Worman HJ. New PPARG mutation leads to lipodystrophy and loss of protein function that is partially restored by a synthetic ligand. Journal of Medical Genetics. 44: e88. PMID 17766367 DOI: 10.1136/Jmg.2007.050567  0.422
2007 Muchir A, Pavlidis P, Bonne G, Hayashi YK, Worman HJ. Activation of MAPK in hearts of EMD null mice: similarities between mouse models of X-linked and autosomal dominant Emery Dreifuss muscular dystrophy. Human Molecular Genetics. 16: 1884-95. PMID 17567779 DOI: 10.1093/Hmg/Ddm137  0.726
2007 Worman HJ, Bonne G. "Laminopathies": a wide spectrum of human diseases. Experimental Cell Research. 313: 2121-33. PMID 17467691 DOI: 10.1016/J.Yexcr.2007.03.028  0.449
2007 Muchir A, Pavlidis P, Decostre V, Herron AJ, Arimura T, Bonne G, Worman HJ. Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy. The Journal of Clinical Investigation. 117: 1282-93. PMID 17446932 DOI: 10.1172/Jci29042  0.718
2007 Lüdtke A, Buettner J, Wu W, Muchir A, Schroeter A, Zinn-Justin S, Spuler S, Schmidt HH, Worman HJ. Peroxisome proliferator-activated receptor-gamma C190S mutation causes partial lipodystrophy. The Journal of Clinical Endocrinology and Metabolism. 92: 2248-55. PMID 17356052 DOI: 10.1210/Jc.2005-2624  0.69
2007 Muchir A, Worman HJ. Emery-Dreifuss muscular dystrophy. Current Neurology and Neuroscience Reports. 7: 78-83. PMID 17217858 DOI: 10.1007/S11910-007-0025-3  0.722
2007 Muchir A, Pavlidis P, Decostre V, Herron A, Arimura T, Hayashi Y, Bonne G, Worman H. G.P.5.10 MAPK signaling pathway is commonly activated in hearts of mouse models of autosomal dominant and X-linked Emery–Dreifuss muscular dystrophy Neuromuscular Disorders. 17: 800. DOI: 10.1016/J.Nmd.2007.06.133  0.651
2006 Muchir A, Massart C, van Engelen BG, Lammens M, Bonne G, Worman HJ. Proteasome-mediated degradation of integral inner nuclear membrane protein emerin in fibroblasts lacking A-type lamins. Biochemical and Biophysical Research Communications. 351: 1011-7. PMID 17097067 DOI: 10.1016/J.Bbrc.2006.10.147  0.693
2006 Wang Y, Herron AJ, Worman HJ. Pathology and nuclear abnormalities in hearts of transgenic mice expressing M371K lamin A encoded by an LMNA mutation causing Emery-Dreifuss muscular dystrophy. Human Molecular Genetics. 15: 2479-89. PMID 16825283 DOI: 10.1093/Hmg/Ddl170  0.46
2006 Caputo S, Couprie J, Duband-Goulet I, Kondé E, Lin F, Braud S, Gondry M, Gilquin B, Worman HJ, Zinn-Justin S. The carboxyl-terminal nucleoplasmic region of MAN1 exhibits a DNA binding winged helix domain. The Journal of Biological Chemistry. 281: 18208-15. PMID 16648637 DOI: 10.1074/Jbc.M601980200  0.327
2006 Worman HJ. Inner nuclear membrane and regulation of Smad-mediated signaling. Biochimica Et Biophysica Acta. 1761: 626-31. PMID 16574476 DOI: 10.1016/J.Bbalip.2006.02.010  0.404
2006 Ostlund C, Sullivan T, Stewart CL, Worman HJ. Dependence of diffusional mobility of integral inner nuclear membrane proteins on A-type lamins. Biochemistry. 45: 1374-82. PMID 16445279 DOI: 10.1021/Bi052156N  0.394
2006 Boguslavsky RL, Stewart CL, Worman HJ. Nuclear lamin A inhibits adipocyte differentiation: implications for Dunnigan-type familial partial lipodystrophy. Human Molecular Genetics. 15: 653-63. PMID 16415042 DOI: 10.1093/Hmg/Ddi480  0.378
2006 Worman HJ, Gundersen GG. Here come the SUNs: a nucleocytoskeletal missing link. Trends in Cell Biology. 16: 67-9. PMID 16406617 DOI: 10.1016/J.Tcb.2005.12.006  0.406
2005 Lüdtke A, Heck K, Genschel J, Mehnert H, Spuler S, Worman HJ, Schmidt HH. Long-term treatment experience in a subject with Dunnigan-type familial partial lipodystrophy: efficacy of rosiglitazone. Diabetic Medicine : a Journal of the British Diabetic Association. 22: 1611-3. PMID 16241930 DOI: 10.1111/J.1464-5491.2005.01757.X  0.303
2005 Worman HJ. Inner nuclear membrane and signal transduction. Journal of Cellular Biochemistry. 96: 1185-92. PMID 16211582 DOI: 10.1002/Jcb.20650  0.408
2005 Worman HJ, Courvalin JC. Nuclear envelope, nuclear lamina, and inherited disease. International Review of Cytology. 246: 231-79. PMID 16164970 DOI: 10.1016/S0074-7696(05)46006-4  0.481
2005 Paradisi M, McClintock D, Boguslavsky RL, Pedicelli C, Worman HJ, Djabali K. Dermal fibroblasts in Hutchinson-Gilford progeria syndrome with the lamin A G608G mutation have dysmorphic nuclei and are hypersensitive to heat stress. Bmc Cell Biology. 6: 27. PMID 15982412 DOI: 10.1186/1471-2121-6-27  0.429
2005 Worman HJ. Components of the nuclear envelope and their role in human disease. Novartis Foundation Symposium. 264: 35-42; discussion 42. PMID 15773746 DOI: 10.1002/0470093765.Ch4  0.463
2005 Broers JL, Kuijpers HJ, Ostlund C, Worman HJ, Endert J, Ramaekers FC. Both lamin A and lamin C mutations cause lamina instability as well as loss of internal nuclear lamin organization. Experimental Cell Research. 304: 582-92. PMID 15748902 DOI: 10.1016/J.Yexcr.2004.11.020  0.417
2005 Ostlund C, Garcia-Carrasquillo RM, Belayew A, Worman HJ. Intracellular trafficking and dynamics of double homeodomain proteins. Biochemistry. 44: 2378-84. PMID 15709750 DOI: 10.1021/Bi047992W  0.342
2005 Lin F, Morrison JM, Wu W, Worman HJ. MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-beta signaling. Human Molecular Genetics. 14: 437-45. PMID 15601644 DOI: 10.1093/Hmg/Ddi040  0.38
2004 Ostlund C, Worman HJ. Lamin-associated proteins. Methods in Cell Biology. 78: 829-59. PMID 15646641 DOI: 10.1016/S0091-679X(04)78029-2  0.386
2004 Gilchrist S, Gilbert N, Perry P, Ostlund C, Worman HJ, Bickmore WA. Altered protein dynamics of disease-associated lamin A mutants. Bmc Cell Biology. 5: 46. PMID 15596010 DOI: 10.1186/1471-2121-5-46  0.421
2004 Hutchison CJ, Worman HJ. A-type lamins: guardians of the soma? Nature Cell Biology. 6: 1062-7. PMID 15517000 DOI: 10.1038/Ncb1104-1062  0.36
2004 Muchir A, Worman HJ. The nuclear envelope and human disease. Physiology (Bethesda, Md.). 19: 309-14. PMID 15381760 DOI: 10.1152/Physiol.00022.2004  0.707
2004 Muchir A, Medioni J, Laluc M, Massart C, Arimura T, van der Kooi AJ, Desguerre I, Mayer M, Ferrer X, Briault S, Hirano M, Worman HJ, Mallet A, Wehnert M, Schwartz K, et al. Nuclear envelope alterations in fibroblasts from patients with muscular dystrophy, cardiomyopathy, and partial lipodystrophy carrying lamin A/C gene mutations. Muscle & Nerve. 30: 444-50. PMID 15372542 DOI: 10.1002/Mus.20122  0.704
2004 Worman HJ, Courvalin JC. How do mutations in lamins A and C cause disease? The Journal of Clinical Investigation. 113: 349-51. PMID 14755330 DOI: 10.1172/Jci20832  0.468
2003 Sharma GG, Hwang KK, Pandita RK, Gupta A, Dhar S, Parenteau J, Agarwal M, Worman HJ, Wellinger RJ, Pandita TK. Human heterochromatin protein 1 isoforms HP1(Hsalpha) and HP1(Hsbeta) interfere with hTERT-telomere interactions and correlate with changes in cell growth and response to ionizing radiation. Molecular and Cellular Biology. 23: 8363-76. PMID 14585993 DOI: 10.1128/Mcb.23.22.8363-8376.2003  0.326
2003 Worman HJ, Courvalin JC. Antinuclear antibodies specific for primary biliary cirrhosis. Autoimmunity Reviews. 2: 211-7. PMID 12848948 DOI: 10.1016/S1568-9972(03)00013-2  0.315
2003 Holt I, Ostlund C, Stewart CL, Man Nt, Worman HJ, Morris GE. Effect of pathogenic mis-sense mutations in lamin A on its interaction with emerin in vivo. Journal of Cell Science. 116: 3027-35. PMID 12783988 DOI: 10.1242/Jcs.00599  0.431
2003 Stierlé V, Couprie J, Ostlund C, Krimm I, Zinn-Justin S, Hossenlopp P, Worman HJ, Courvalin JC, Duband-Goulet I. The carboxyl-terminal region common to lamins A and C contains a DNA binding domain. Biochemistry. 42: 4819-28. PMID 12718522 DOI: 10.1021/Bi020704G  0.322
2003 Ostlund C, Worman HJ. Nuclear envelope proteins and neuromuscular diseases. Muscle & Nerve. 27: 393-406. PMID 12661041 DOI: 10.1002/Mus.10302  0.454
2003 Favreau C, Dubosclard E, Ostlund C, Vigouroux C, Capeau J, Wehnert M, Higuet D, Worman HJ, Courvalin JC, Buendia B. Expression of lamin A mutated in the carboxyl-terminal tail generates an aberrant nuclear phenotype similar to that observed in cells from patients with Dunnigan-type partial lipodystrophy and Emery-Dreifuss muscular dystrophy. Experimental Cell Research. 282: 14-23. PMID 12490190 DOI: 10.1006/excr.2002.5669  0.323
2002 Worman HJ, Courvalin JC. The nuclear lamina and inherited disease. Trends in Cell Biology. 12: 591-8. PMID 12495848 DOI: 10.1016/S0962-8924(02)02401-7  0.446
2002 Krimm I, Ostlund C, Gilquin B, Couprie J, Hossenlopp P, Mornon JP, Bonne G, Courvalin JC, Worman HJ, Zinn-Justin S. The Ig-like structure of the C-terminal domain of lamin A/C, mutated in muscular dystrophies, cardiomyopathy, and partial lipodystrophy. Structure (London, England : 1993). 10: 811-23. PMID 12057196 DOI: 10.1016/S0969-2126(02)00777-3  0.416
2002 Hwang KK, Worman HJ. Gene regulation by human orthologs of Drosophila heterochromatin protein 1. Biochemical and Biophysical Research Communications. 293: 1217-22. PMID 12054505 DOI: 10.1016/S0006-291X(02)00377-7  0.348
2001 Holmer L, Worman HJ. Inner nuclear membrane proteins: functions and targeting. Cellular and Molecular Life Sciences : Cmls. 58: 1741-7. PMID 11766875 DOI: 10.1007/Pl00000813  0.37
2001 Hwang KK, Eissenberg JC, Worman HJ. Transcriptional repression of euchromatic genes by Drosophila heterochromatin protein 1 and histone modifiers. Proceedings of the National Academy of Sciences of the United States of America. 98: 11423-7. PMID 11562500 DOI: 10.1073/Pnas.211303598  0.367
2001 Wolff N, Gilquin B, Courchay K, Callebaut I, Worman HJ, Zinn-Justin S. Structural analysis of emerin, an inner nuclear membrane protein mutated in X-linked Emery-Dreifuss muscular dystrophy Febs Letters. 501: 171-176. PMID 11470279 DOI: 10.1016/S0014-5793(01)02649-7  0.451
2001 Laguri C, Gilquin B, Wolff N, Romi-Lebrun R, Courchay K, Callebaut I, Worman HJ, Zinn-Justin S. Structural characterization of the LEM motif common to three human inner nuclear membrane proteins Structure. 9: 503-511. PMID 11435115 DOI: 10.1016/S0969-2126(01)00611-6  0.346
2001 Ma J, Hwang KK, Worman HJ, Courvalin JC, Eissenberg JC. Expression and functional analysis of three isoforms of human heterochromatin-associated protein HP1 in Drosophila. Chromosoma. 109: 536-44. PMID 11305786 DOI: 10.1007/S004120000113  0.339
2001 Wilson KL, Benavente R, Burke B, Craigie R, Foisner R, Furukawa K, Gerace L, Goldman RD, Gruenbaum Y, Harris C, Hutchison CJ, Krohne G, Morris GE, Otto H, Simon AJ, ... Worman HJ, et al. Problems with LAP nomenclature. Nature Cell Biology. 3: E90. PMID 11283624 DOI: 10.1038/35070147  0.494
2000 Terjung B, Spengler U, Sauerbruch T, Worman HJ. 'Atypical p-ANCA' in IBD and hepatobiliary disorders react with a 50-kilodalton nuclear envelope protein of neutrophils and myeloid cell lines Gastroenterology. 119: 310-322. PMID 10930366 DOI: 10.1053/Gast.2000.9366  0.342
2000 Lin F, Blake DL, Callebaut I, Skerjanc IS, Holmer L, McBurney MW, Paulin-Levasseur M, Worman HJ. MAN1, an inner nuclear membrane protein that shares the LEM domain with lamina-associated polypeptide 2 and emerin Journal of Biological Chemistry. 275: 4840-4847. PMID 10671519 DOI: 10.1074/Jbc.275.7.4840  0.375
1999 Barton RM, Worman HJ. Prenylated prelamin A interacts with Narf, a novel nuclear protein Journal of Biological Chemistry. 274: 30008-30018. PMID 10514485 DOI: 10.1074/Jbc.274.42.30008  0.373
1999 Minc E, Allory Y, Worman HJ, Courvalin JC, Buendia B. Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells Chromosoma. 108: 220-234. PMID 10460410 DOI: 10.1007/S004120050372  0.346
1999 Pierce T, Worman HJ, Holy J. Neuronal differentiation of NT2/D1 teratocarcinoma cells is accompanied by a loss of lamin A/C expression and an increase in lamin B1 expression Experimental Neurology. 157: 241-250. PMID 10364436 DOI: 10.1006/Exnr.1999.7060  0.301
1998 Ye Q, Barton RM, Worman HJ. Nuclear lamin-binding proteins. Sub-Cellular Biochemistry. 31: 587-610. PMID 9932507  0.424
1998 Holmer L, Pezhman A, Worman HJ. The human lamin B receptor/sterol reductase multigene family Genomics. 54: 469-476. PMID 9878250 DOI: 10.1006/Geno.1998.5615  0.367
1997 Lin F, Worman HJ. Expression of nuclear lamins in human tissues and cancer cell lines and transcription from the promoters of the lamin A/C and B1 genes Experimental Cell Research. 236: 378-384. PMID 9367621 DOI: 10.1006/Excr.1997.3735  0.336
1997 Ellenberg J, Siggia ED, Moreira JE, Smith CL, Presley JF, Worman HJ, Lippincott-Schwartz J. Nuclear membrane dynamics and reassembly in living cells: Targeting of an inner nuclear membrane protein in interphase and mitosis Journal of Cell Biology. 138: 1193-1206. PMID 9298976 DOI: 10.1083/Jcb.138.6.1193  0.308
1997 Worman HJ. Molecular biological methods in diagnosis and treatment of liver diseases Clinical Chemistry. 43: 1476-1486. PMID 9265898 DOI: 10.1093/Clinchem/43.8.1476  0.314
1997 Ye Q, Callebaut I, Pezhman A, Courvalin JC, Worman HJ. Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR. The Journal of Biological Chemistry. 272: 14983-9. PMID 9169472 DOI: 10.1074/Jbc.272.23.14983  0.504
1997 Courvalin JC, Worman HJ. Nuclear envelope protein autoantibodies in primary biliary cirrhosis Seminars in Liver Disease. 17: 79-90. PMID 9089913 DOI: 10.1055/S-2007-1007185  0.366
1996 Favreau C, Worman HJ, Wozniak RW, Frappier T, Courvalin JC. Cell cycle-dependent phosphorylation of nucleoporins and nuclear pore membrane protein Gp210 Biochemistry. 35: 8035-8044. PMID 8672508 DOI: 10.1021/Bi9600660  0.364
1996 Ye Q, Worman HJ. Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1. The Journal of Biological Chemistry. 271: 14653-6. PMID 8663349 DOI: 10.1074/Jbc.271.25.14653  0.528
1996 Lin F, Noyer CM, Ye Q, Courvalin JC, Worman HJ. Autoantibodies from patients with primary biliary cirrhosis recognize a region within the nucleoplasmic domain of inner nuclear membrane protein LBR. Hepatology (Baltimore, Md.). 23: 57-61. PMID 8550049 DOI: 10.1002/Hep.510230109  0.489
1995 Soullam B, Worman HJ. Signals and structural features involved in integral membrane protein targeting to the inner nuclear membrane Journal of Cell Biology. 130: 15-27. PMID 7790369 DOI: 10.1083/Jcb.130.1.15  0.357
1995 Ye Q, Worman HJ. Protein-protein interactions between human nuclear lamins expressed in yeast. Experimental Cell Research. 219: 292-8. PMID 7628545 DOI: 10.1006/Excr.1995.1230  0.529
1995 Lin F, Worman HJ. Structural organization of the human gene (LMNB1) encoding nuclear lamin B1 Genomics. 27: 230-236. PMID 7557986 DOI: 10.1006/Geno.1995.1036  0.369
1994 Ye Q, Worman HJ. Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane. The Journal of Biological Chemistry. 269: 11306-11. PMID 8157662  0.44
1992 Courvalin JC, Segil N, Blobel G, Worman HJ. The lamin B receptor of the inner nuclear membrane undergoes mitosis-specific phosphorylation and is a substrate for p34cdc2-type protein kinase. The Journal of Biological Chemistry. 267: 19035-8. PMID 1326541  0.473
1990 Worman HJ, Evans CD, Blobel G. The lamin B receptor of the nuclear envelope inner membrane: a polytopic protein with eight potential transmembrane domains. The Journal of Cell Biology. 111: 1535-42. PMID 2170422  0.47
1990 Courvalin JC, Lassoued K, Worman HJ, Blobel G. Identification and characterization of autoantibodies against the nuclear envelope lamin B receptor from patients with primary biliary cirrhosis. The Journal of Experimental Medicine. 172: 961-7. PMID 2167346 DOI: 10.1084/Jem.172.3.961  0.449
1988 Worman HJ, Yuan J, Blobel G, Georgatos SD. A lamin B receptor in the nuclear envelope. Proceedings of the National Academy of Sciences of the United States of America. 85: 8531-4. PMID 2847165 DOI: 10.1073/Pnas.85.22.8531  0.436
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