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Fenfei Leng - Publications

Affiliations: 
Florida International University, Miami, FL, United States 
Area:
Medical Biophysics
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56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Deng Z, Chapagain P, Leng F. Macromolecular Crowding Potently Stimulates DNA Supercoiling Activity of Mycobacterium tuberculosis DNA Gyrase. The Journal of Biological Chemistry. 105439. PMID 37944619 DOI: 10.1016/j.jbc.2023.105439  0.413
2023 Dias M, Chapagain T, Leng F. A Fluorescence-Based, T5 Exonuclease-Amplified DNA Cleavage Assay for Discovering Bacterial DNA Gyrase Poisons. Biorxiv : the Preprint Server For Biology. PMID 37904923 DOI: 10.1101/2023.10.16.562555  0.415
2023 Tantak M, Rayala R, Deng Z, Bunnell A, Wang T, Chaudhari P, Leng F, Nefzi A. Polyheterocyclic peptidomimetics: Parallel solid phase synthesis of oligo cyclic guanidines and their inhibition activity against Mycobacterium tuberculosis DNA gyrase. Bioorganic & Medicinal Chemistry Letters. 93: 129439. PMID 37557925 DOI: 10.1016/j.bmcl.2023.129439  0.325
2022 Alfonso EE, Deng Z, Boaretto D, Hood BL, Vasile S, Smith LH, Chambers JW, Chapagain P, Leng F. Novel and Structurally Diversified Bacterial DNA Gyrase Inhibitors Discovered through a Fluorescence-Based High-Throughput Screening Assay. Acs Pharmacology & Translational Science. 5: 932-944. PMID 36268121 DOI: 10.1021/acsptsci.2c00113  0.377
2022 Alfonso EE, Troche R, Deng Z, Annamalai T, Chapagain P, Tse-Dinh YC, Leng F. Potent Inhibition of Bacterial DNA Gyrase by Digallic Acid and Other Gallate Derivatives. Chemmedchem. e202200301. PMID 36161274 DOI: 10.1002/cmdc.202200301  0.357
2022 Sipe SN, Jeanne Dit Fouque K, Garabedian A, Leng F, Fernandez-Lima F, Brodbelt JS. Exploring the Conformations and Binding Location of HMGA2·DNA Complexes Using Ion Mobility Spectrometry and 193 nm Ultraviolet Photodissociation Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 35687872 DOI: 10.1021/jasms.2c00083  0.488
2022 Jeanne Dit Fouque K, Sipe SN, Garabedian A, Mejia G, Su L, Hossen ML, Chapagain PP, Leng F, Brodbelt JS, Fernandez-Lima F. Exploring the Conformational and Binding Dynamics of HMGA2·DNA Complexes Using Trapped Ion Mobility Spectrometry-Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 35687119 DOI: 10.1021/jasms.2c00101  0.57
2022 Garabedian A, Jeanne Dit Fouque K, Chapagain PP, Leng F, Fernandez-Lima F. AT-hook peptides bind the major and minor groove of AT-rich DNA duplexes. Nucleic Acids Research. 50: 2431-2439. PMID 35212375 DOI: 10.1093/nar/gkac115  0.581
2021 Yan Y, Xu W, Kumar S, Zhang A, Leng F, Dunlap D, Finzi L. Negative DNA supercoiling makes protein-mediated looping deterministic and ergodic within the bacterial doubling time. Nucleic Acids Research. PMID 34723343 DOI: 10.1093/nar/gkab946  0.374
2021 Deng Z, Leng F. A T5 Exonuclease-Based Assay for DNA Topoisomerases and DNA Intercalators. Acs Omega. 6: 12205-12212. PMID 34056374 DOI: 10.1021/acsomega.1c00962  0.382
2020 Su L, Bryan N, Battista S, Freitas J, Garabedian A, D'Alessio F, Romano M, Falanga F, Fusco A, Kos L, Chambers J, Fernandez-Lima F, Chapagain PP, Vasile S, Smith L, ... Leng F, et al. Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays. Scientific Reports. 10: 18850. PMID 33139812 DOI: 10.1038/s41598-020-75890-0  0.614
2019 Wang Y, Rakela S, Chambers JW, Hua ZC, Muller MT, Nitiss JL, Tse-Dinh YC, Leng F. Kinetic Study of DNA Topoisomerases by Supercoiling-Dependent Fluorescence Quenching. Acs Omega. 4: 18413-18422. PMID 31720544 DOI: 10.1021/acsomega.9b02676  0.424
2019 Dages S, Zhi X, Leng F. Fis protein forms DNA topological barriers to confine transcription-coupled DNA supercoiling in Escherichia coli. Febs Letters. PMID 31639222 DOI: 10.1002/1873-3468.13643  0.45
2019 Jeanne Dit Fouque K, Garabedian A, Leng F, Tse-Dinh YC, Fernandez-Lima F. Microheterogeneity of Topoisomerase IA/IB and Their DNA-Bound States. Acs Omega. 4: 3619-3626. PMID 30842985 DOI: 10.1021/acsomega.8b02887  0.506
2019 Su L, Chambers J, Leng F. Tight Binding of Natural Polyphenols to the Intrinsically Disordered Mammalian High Mobility Group Protein At-Hook 2 Biophysical Journal. 116: 482a. DOI: 10.1016/j.bpj.2018.11.2601  0.427
2018 Dages S, Dages K, Zhi X, Leng F. Inhibition of the gyrA promoter by transcription-coupled DNA supercoiling in Escherichia coli. Scientific Reports. 8: 14759. PMID 30282997 DOI: 10.1038/s41598-018-33089-4  0.349
2018 Garabedian A, Bolufer A, Leng F, Fernandez-Lima F. Peptide Sequence Influence on the Conformational Dynamics and DNA binding of the Intrinsically Disordered AT-Hook 3 Peptide. Scientific Reports. 8: 10783. PMID 30018295 DOI: 10.1038/s41598-018-28956-z  0.401
2018 Butcher D, Chapagain PP, Leng F, Fernandez-Lima F. Differentiating Parallel and Antiparallel DNA Duplexes in the Gas Phase Using Trapped Ion Mobility Spectrometry. The Journal of Physical Chemistry. B. PMID 29886735 DOI: 10.1021/Acs.Jpcb.7B12544  0.342
2018 Yan Y, Ding Y, Leng F, Dunlap D, Finzi L. Protein-mediated loops in supercoiled DNA create large topological domains. Nucleic Acids Research. PMID 29538766 DOI: 10.1093/Nar/Gky153  0.522
2018 Yan Y, Leng F, Finzi L, Dunlap D. Protein-mediated looping of DNA under tension requires supercoiling. Nucleic Acids Research. PMID 29365152 DOI: 10.1093/Nar/Gky021  0.443
2018 Liu Y, Hua ZC, Leng F. DNA Supercoiling Measurement in Bacteria. Methods in Molecular Biology (Clifton, N.J.). 1703: 63-73. PMID 29177733 DOI: 10.1007/978-1-4939-7459-7_4  0.388
2018 Su L, Vasile S, Smith L, Leng F. Identification of Suramin as a Potent and Specific Inhibitor of the Mammalian High Mobility Group Protein at-Hook 2 (HMGA2)-DNA Interactions Biophysical Journal. 114: 443a. DOI: 10.1016/j.bpj.2017.11.2450  0.473
2017 Liu Y, Berrido AM, Hua ZC, Tse-Dinh YC, Leng F. Biochemical and biophysical properties of positively supercoiled DNA. Biophysical Chemistry. PMID 28887044 DOI: 10.1016/J.Bpc.2017.08.008  0.474
2017 Zhi X, Dages S, Dages K, Liu Y, Hua ZC, Makemson J, Leng F. Transient and dynamic DNA supercoiling potently stimulates the leu-500 promoter in Escherichia coli. The Journal of Biological Chemistry. PMID 28696257 DOI: 10.1074/jbc.M117.794628  0.306
2017 Ranjan N, Story S, Fulcrand G, Leng F, Ahmad M, King A, Sur S, Wang W, Tse-Dinh YC, Arya DP. Selective Inhibition of E. coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono and Bisbenzimidazoles. Journal of Medicinal Chemistry. PMID 28513176 DOI: 10.1021/Acs.Jmedchem.7B00191  0.396
2016 Leng F. Protein-induced DNA linking number change by sequence-specific DNA binding proteins and its biological effects. Biophysical Reviews. 8: 197-207. PMID 28510223 DOI: 10.1007/s12551-016-0204-z  0.592
2016 Leng F. Protein-induced DNA linking number change by sequence-specific DNA binding proteins and its biological effects. Biophysical Reviews. 8: 123-133. PMID 28510217 DOI: 10.1007/s12551-016-0239-1  0.592
2016 Gu M, Berrido A, Gonzalez WG, Miksovska J, Chambers JW, Leng F. Fluorescently labeled circular DNA molecules for DNA topology and topoisomerases. Scientific Reports. 6: 36006. PMID 27796331 DOI: 10.1038/Srep36006  0.389
2016 Fulcrand G, Chapagain P, Dunlap D, Leng F. Direct observation of a 91 bp LacI-mediated, negatively supercoiled DNA loop by atomic force microscope. Febs Letters. 590: 613-8. PMID 26878689 DOI: 10.1002/1873-3468.12094  0.338
2016 Fulcrand G, Dages S, Zhi X, Chapagain P, Gerstman BS, Dunlap D, Leng F. DNA supercoiling, a critical signal regulating the basal expression of the lac operon in Escherichia coli. Scientific Reports. 6: 19243. PMID 26763930 DOI: 10.1038/Srep19243  0.477
2016 Yan Y, Leng F, Dunlap DD, Finzi L. HU Protein and DNA Supercoiling Dramatically Enhance Lac-Repressor-Mediated DNA Looping Biophysical Journal. 110: 236a. DOI: 10.1016/J.Bpj.2015.11.1302  0.501
2015 Alonso N, Guillen R, Chambers JW, Leng F. A rapid and sensitive high-throughput screening method to identify compounds targeting protein-nucleic acids interactions. Nucleic Acids Research. 43: e52. PMID 25653160 DOI: 10.1093/Nar/Gkv069  0.551
2014 Ding Y, Manzo C, Fulcrand G, Leng F, Dunlap D, Finzi L. DNA supercoiling: a regulatory signal for the λ repressor. Proceedings of the National Academy of Sciences of the United States of America. 111: 15402-7. PMID 25319264 DOI: 10.1073/Pnas.1320644111  0.428
2014 Schenk ER, Ridgeway ME, Park MA, Leng F, Fernandez-Lima F. Isomerization kinetics of AT hook decapeptide solution structures. Analytical Chemistry. 86: 1210-4. PMID 24364733 DOI: 10.1021/Ac403386Q  0.308
2014 Ding Y, Manzo C, Fulcrand G, Leng F, Dunlap D, Finzi L. DNA supercoiling: A regulatory signal for the λ repressor Proceedings of the National Academy of Sciences of the United States of America. 111: 15402-15407. DOI: 10.1073/pnas.1320644111  0.34
2013 Leng F. DNA bending by proteins: utilizing plasmid pBendAT as a tool. Methods in Molecular Biology (Clifton, N.J.). 1054: 267-82. PMID 23913299 DOI: 10.1007/978-1-62703-565-1_18  0.538
2013 Fulcrand G, Zhi X, Leng F. Transcription-coupled DNA supercoiling in defined protein systems and in E. coli topA mutant strains. Iubmb Life. 65: 615-22. PMID 23757201 DOI: 10.1002/iub.1179  0.403
2013 Zhi X, Leng F. Dependence of transcription-coupled DNA supercoiling on promoter strength in Escherichia coli topoisomerase I deficient strains. Gene. 514: 82-90. PMID 23201416 DOI: 10.1016/j.gene.2012.11.011  0.345
2012 Xu X, Zhi X, Leng F. Determining DNA supercoiling enthalpy by isothermal titration calorimetry. Biochimie. 94: 2665-72. PMID 22940593 DOI: 10.1016/j.biochi.2012.08.002  0.475
2011 Leng F, Chen B, Dunlap DD. Dividing a supercoiled DNA molecule into two independent topological domains. Proceedings of the National Academy of Sciences of the United States of America. 108: 19973-8. PMID 22123985 DOI: 10.1073/pnas.1109854108  0.541
2011 Xu X, Leng F. A rapid procedure to purify Escherichia coli DNA topoisomerase I. Protein Expression and Purification. 77: 214-9. PMID 21310243 DOI: 10.1016/j.pep.2011.02.002  0.357
2010 Chen B, Xiao Y, Liu C, Li C, Leng F. DNA linking number change induced by sequence-specific DNA-binding proteins. Nucleic Acids Research. 38: 3643-54. PMID 20185570 DOI: 10.1093/Nar/Gkq078  0.615
2010 Chen B, Young J, Leng F. DNA bending by the mammalian high-mobility group protein AT hook 2. Biochemistry. 49: 1590-5. PMID 20108983 DOI: 10.1021/bi901881c  0.55
2009 Joynt S, Morillo V, Leng F. Binding the mammalian high mobility group protein AT-hook 2 to AT-rich deoxyoligonucleotides: enthalpy-entropy compensation. Biophysical Journal. 96: 4144-52. PMID 19450485 DOI: 10.1016/j.bpj.2009.02.015  0.619
2008 Miao Y, Cui T, Leng F, Wilson WD. Inhibition of high-mobility-group A2 protein binding to DNA by netropsin: a biosensor-surface plasmon resonance assay. Analytical Biochemistry. 374: 7-15. PMID 18023407 DOI: 10.1016/J.Ab.2007.10.023  0.65
2007 Cui T, Leng F. Specific recognition of AT-rich DNA sequences by the mammalian high mobility group protein AT-hook 2: a SELEX study. Biochemistry. 46: 13059-66. PMID 17956125 DOI: 10.1021/bi701269s  0.664
2007 Cui T, Joynt S, Morillo V, Baez M, Hua Z, Wang X, Leng F. Large scale preparation of the mammalian high mobility group protein A2 for biophysical studies. Protein and Peptide Letters. 14: 87-91. PMID 17266655  0.599
2005 Cui T, Wei S, Brew K, Leng F. Energetics of binding the mammalian high mobility group protein HMGA2 to poly(dA-dT)2 and poly(dA)-poly(dT). Journal of Molecular Biology. 352: 629-45. PMID 16109425 DOI: 10.1016/J.Jmb.2005.07.048  0.656
2004 Leng F, Amado L, McMacken R. Coupling DNA supercoiling to transcription in defined protein systems. The Journal of Biological Chemistry. 279: 47564-71. PMID 15342629 DOI: 10.1074/Jbc.M403798200  0.398
2003 Leng F, Chaires JB, Waring MJ. Energetics of echinomycin binding to DNA Nucleic Acids Research. 31: 6191-6197. PMID 14576305 DOI: 10.1093/Nar/Gkg826  0.517
2002 Leng F, McMacken R. Potent stimulation of transcription-coupled DNA supercoiling by sequence-specific DNA-binding proteins. Proceedings of the National Academy of Sciences of the United States of America. 99: 9139-44. PMID 12093906 DOI: 10.1073/Pnas.142002099  0.497
1998 Leng F, Graves D, Chaires JB. Chemical cross-linking of ethidium to DNA by glyoxal Biochimica Et Biophysica Acta - Gene Structure and Expression. 1442: 71-81. PMID 9767119 DOI: 10.1016/S0167-4781(98)00122-5  0.34
1998 Leng F, Priebe W, Chaires JB. Ultratight DNA binding of a new bisintercalating anthracycline antibiotic Biochemistry. 37: 1743-1753. PMID 9485299 DOI: 10.1021/Bi9720742  0.589
1997 Hu GG, Shui X, Leng F, Priebe W, Chaires JB, Williams LD. Structure of a DNA-bisdaunomycin complex. Biochemistry. 36: 5940-6. PMID 9166763 DOI: 10.1021/Bi9705218  0.33
1997 Chaires JB, Leng F, Przewloka T, Fokt I, Ling YH, Perez-Soler R, Priebe W. Structure-based design of a new bisintercalating anthracycline antibiotic Journal of Medicinal Chemistry. 40: 261-266. PMID 9022792 DOI: 10.1021/Jm9607414  0.481
1996 Leng F, Savkur R, Fokt I, Przewloka T, Priebe W, Chaires JB. Base specific and regioselective chemical cross-linking of daunorubicin to DNA Journal of the American Chemical Society. 118: X-4737. DOI: 10.1021/Ja9542606  0.405
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