| Year |
Citation |
Score |
| 2023 |
Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA, Abbracchio MP, Abraham G, Agoulnik A, Alexander W, ... ... Karnik S, et al. The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. British Journal of Pharmacology. S23-S144. PMID 38123151 DOI: 10.1111/bph.16177 |
0.686 |
|
| 2022 |
Singh KD, Karnik SS. Structural Perspective on the Mechanism of Signal Activation, Ligand Selectivity and Allosteric Modulation in Angiotensin Receptors: IUPHAR Review 34. British Journal of Pharmacology. PMID 35318654 DOI: 10.1111/bph.15840 |
0.447 |
|
| 2021 |
Alexander SP, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Abbracchio MP, Alexander W, ... ... Karnik S, et al. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. British Journal of Pharmacology. 178: S27-S156. PMID 34529832 DOI: 10.1111/bph.15538 |
0.686 |
|
| 2021 |
Singh KD, Jara ZP, Harford T, Saha PP, Pardhi TR, Desnoyer R, Karnik SS. Novel allosteric ligands of the angiotensin receptor AT1R as autoantibody blockers. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34380734 DOI: 10.1073/pnas.2019126118 |
0.405 |
|
| 2021 |
Singh KD, Karnik SS. Current Trends in GPCR Allostery. The Journal of Membrane Biology. PMID 33471142 DOI: 10.1007/s00232-020-00167-6 |
0.385 |
|
| 2021 |
Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Dhanachandra Singh K, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, et al. Class A Orphans in GtoPdb v.2021.3 Iuphar/Bps Guide to Pharmacology Cite. 2021. DOI: 10.2218/gtopdb/f16/2021.3 |
0.381 |
|
| 2020 |
Chung MK, Karnik S, Saef J, Bergmann C, Barnard J, Lederman MM, Tilton J, Cheng F, Harding CV, Young JB, Mehta N, Cameron SJ, McCrae KR, Schmaier AH, Smith JD, et al. SARS-CoV-2 and ACE2: The biology and clinical data settling the ARB and ACEI controversy. Ebiomedicine. 58: 102907. PMID 32771682 DOI: 10.1016/J.Ebiom.2020.102907 |
0.404 |
|
| 2020 |
Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Dhanachandra Singh K, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, et al. Class A Orphans (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2020. DOI: 10.2218/gtopdb/f16/2020.5 |
0.41 |
|
| 2019 |
Jara ZP, Singh KD, Unal H, Desnoyer R, Yokota R, Pesquero JL, Casarini DE, Karnik SS. Effect of novel GPCR ligands on blood pressure and vascular homeostasis. Methods in Cell Biology. 149: 215-238. PMID 30616822 DOI: 10.1016/bs.mcb.2018.10.001 |
0.314 |
|
| 2019 |
Alexander W, Bernstein KE, Catt KJ, De Gasparo M, Dhanachandra Singh K, Eguchi S, Escher E, Goodfriend TL, Horiuchi M, Hunyady L, Husain A, Inagami T, Karnik S, Kemp J, Thomas WG, et al. Angiotensin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f6/2019.4 |
0.414 |
|
| 2019 |
Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, Mpamhanga C, et al. Class A Orphans (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f16/2019.4 |
0.395 |
|
| 2018 |
Takezako T, Unal H, Karnik SS, Node K. The non-biphenyl-tetrazole AT1 receptor blocker eprosartan is a unique and robust inverse agonist of the active state of AT1 receptor. British Journal of Pharmacology. PMID 29570771 DOI: 10.1111/bph.14213 |
0.36 |
|
| 2018 |
Seara F, Nakagawa P, Gomez JA, Deng G, Sebag JA, Karnik SS, Grobe JL, Sigmund CD. Abstract 104: DOCA Induced Natriorexigenic and Hypertensive Effects are Blunted by Central Infusion of AT1 Receptor Biased Agonist TRV120027 Hypertension. 72. DOI: 10.1161/Hyp.72.Suppl_1.104 |
0.361 |
|
| 2017 |
Singh KD, Unal H, Desnoyer R, Karnik SS. Divergent Spatiotemporal Interaction of Angiotensin Receptor Blocking Drugs with Angiotensin Type 1 Receptor. Journal of Chemical Information and Modeling. PMID 29195045 DOI: 10.1021/acs.jcim.7b00424 |
0.371 |
|
| 2017 |
Takezako T, Unal H, Karnik SS, Node K. Current Topics in Angiotensin II Type 1 Receptor Research: Focus on Inverse Agonism, Receptor Dimerization and Biased Agonism. Pharmacological Research. PMID 28648738 DOI: 10.1016/j.phrs.2017.06.013 |
0.482 |
|
| 2017 |
Karnik SS, Khuraijam D, Tirupula K, Unal H. Significance of Ang(1-7) coupling with MAS1 and other GPCRs to the Renin-Angiotensin System: IUPHAR Review "X". British Journal of Pharmacology. PMID 28194766 DOI: 10.1111/bph.13742 |
0.477 |
|
| 2016 |
Singh KD, Karnik SS. Angiotensin Receptors: Structure, Function, Signaling and Clinical Applications. Journal of Cell Signaling. 1. PMID 27512731 DOI: 10.4172/jcs.1000111 |
0.527 |
|
| 2015 |
Tirupula KC, Ithychanda SS, Mohan ML, Naga Prasad SV, Qin J, Karnik SS. G protein-coupled receptors directly bind Filamin A with high-affinity and promote Filamin phosphorylation. Biochemistry. PMID 26460884 DOI: 10.1021/acs.biochem.5b00975 |
0.314 |
|
| 2015 |
Zhang H, Unal H, Desnoyer R, Han GW, Patel N, Katritch V, Karnik SS, Cherezov V, Stevens RC. Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor. The Journal of Biological Chemistry. PMID 26420482 DOI: 10.1074/Jbc.M115.689000 |
0.382 |
|
| 2015 |
Karnik SS, Unal H, Kemp JR, Tirupula KC, Eguchi S, Vanderheyden PM, Thomas WG. International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli [corrected]. Pharmacological Reviews. 67: 754-819. PMID 26315714 DOI: 10.1124/pr.114.010454 |
0.67 |
|
| 2015 |
Takezako T, Unal H, Karnik SS, Node K. Structure-Function Basis of Attenuated Inverse Agonism of Angiotensin II Type 1 Receptor Blockers for Active-State Angiotensin II Type 1 Receptor. Molecular Pharmacology. 88: 488-501. PMID 26121982 DOI: 10.1124/mol.115.099176 |
0.372 |
|
| 2014 |
Kemp JR, Unal H, Desnoyer R, Yue H, Bhatnagar A, Karnik SS. Angiotensin II-regulated microRNA 483-3p directly targets multiple components of the renin-angiotensin system. Journal of Molecular and Cellular Cardiology. 75: 25-39. PMID 24976017 DOI: 10.1016/J.Yjmcc.2014.06.008 |
0.621 |
|
| 2014 |
Unal H, Karnik SS. Constitutive activity in the angiotensin II type 1 receptor: discovery and applications. Advances in Pharmacology (San Diego, Calif.). 70: 155-74. PMID 24931196 DOI: 10.1016/B978-0-12-417197-8.00006-7 |
0.481 |
|
| 2013 |
Miura S, Nakao N, Hanzawa H, Matsuo Y, Saku K, Karnik SS. Reassessment of the unique mode of binding between angiotensin II type 1 receptor and their blockers. Plos One. 8: e79914. PMID 24260317 DOI: 10.1371/journal.pone.0079914 |
0.385 |
|
| 2013 |
Bhatnagar A, Unal H, Jagannathan R, Kaveti S, Duan ZH, Yong S, Vasanji A, Kinter M, Desnoyer R, Karnik SS. Interaction of G-protein βγ complex with chromatin modulates GPCR-dependent gene regulation. Plos One. 8: e52689. PMID 23326349 DOI: 10.1371/Journal.Pone.0052689 |
0.303 |
|
| 2013 |
Unal H, Jagannathan R, Bhatnagar A, Tirupula K, Desnoyer R, Karnik SS. Long range effect of mutations on specific conformational changes in the extracellular loop 2 of angiotensin II type 1 receptor. The Journal of Biological Chemistry. 288: 540-51. PMID 23139413 DOI: 10.1074/jbc.M112.392514 |
0.343 |
|
| 2013 |
Miura S, Okabe A, Matsuo Y, Karnik SS, Saku K. Unique binding behavior of the recently approved angiotensin II receptor blocker azilsartan compared with that of candesartan. Hypertension Research : Official Journal of the Japanese Society of Hypertension. 36: 134-9. PMID 23034464 DOI: 10.1038/HR.2013.16 |
0.4 |
|
| 2013 |
Miura SI, Kiya Y, Hanzawa H, Nakao N, Fujino M, Imaizumi S, Matsuo Y, Yanagisawa H, Koike H, Komuro I, Karnik SS, Saku K. Correction: Small molecules with similar structures exhibit agonist, neutral antagonist or inverse agonist activity toward angiotensin II type 1 receptor (PLoS ONE) Plos One. 8. DOI: 10.1371/annotation/158ee8e2-b9da-4d86-9085-457700f96b92 |
0.356 |
|
| 2012 |
Miura S, Kiya Y, Hanzawa H, Nakao N, Fujino M, Imaizumi S, Matsuo Y, Yanagisawa H, Koike H, Komuro I, Karnik SS, Saku K. Small molecules with similar structures exhibit agonist, neutral antagonist or inverse agonist activity toward angiotensin II type 1 receptor. Plos One. 7: e37974. PMID 22719858 DOI: 10.1371/journal.pone.0037974 |
0.444 |
|
| 2012 |
Unal H, Karnik SS. Domain coupling in GPCRs: the engine for induced conformational changes. Trends in Pharmacological Sciences. 33: 79-88. PMID 22037017 DOI: 10.1016/j.tips.2011.09.007 |
0.368 |
|
| 2012 |
Kiya Y, Miura S, Matsuo Y, Karnik SS, Saku K. Abilities of candesartan and other AT(1) receptor blockers to impair angiotensin II-induced AT(1) receptor activation after wash-out. Journal of the Renin-Angiotensin-Aldosterone System : Jraas. 13: 76-83. PMID 21824992 DOI: 10.1177/1470320311417478 |
0.397 |
|
| 2011 |
Miura S, Karnik SS, Saku K. Review: angiotensin II type 1 receptor blockers: class effects versus molecular effects. Journal of the Renin-Angiotensin-Aldosterone System : Jraas. 12: 1-7. PMID 20603272 DOI: 10.1177/1470320310370852 |
0.344 |
|
| 2010 |
Jagannathan R, Kaveti S, Desnoyer RW, Willard B, Kinter M, Karnik SS. AT1 receptor induced alterations in histone H2A reveal novel insights into GPCR control of chromatin remodeling. Plos One. 5: e12552. PMID 20838438 DOI: 10.1371/Journal.Pone.0012552 |
0.313 |
|
| 2010 |
Fujino M, Miura S, Kiya Y, Tominaga Y, Matsuo Y, Karnik SS, Saku K. A small difference in the molecular structure of angiotensin II receptor blockers induces AT₁ receptor-dependent and -independent beneficial effects. Hypertension Research : Official Journal of the Japanese Society of Hypertension. 33: 1044-52. PMID 20668453 DOI: 10.1038/hr.2010.135 |
0.432 |
|
| 2010 |
Unal H, Jagannathan R, Bhat MB, Karnik SS. Ligand-specific conformation of extracellular loop-2 in the angiotensin II type 1 receptor. The Journal of Biological Chemistry. 285: 16341-50. PMID 20299456 DOI: 10.1074/jbc.M109.094870 |
0.438 |
|
| 2010 |
Miura S, Matsuo Y, Kiya Y, Karnik SS, Saku K. Molecular mechanisms of the antagonistic action between AT1 and AT2 receptors. Biochemical and Biophysical Research Communications. 391: 85-90. PMID 19896468 DOI: 10.1016/j.bbrc.2009.11.008 |
0.453 |
|
| 2008 |
Miura S, Kiya Y, Kanazawa T, Imaizumi S, Fujino M, Matsuo Y, Karnik SS, Saku K. Differential bonding interactions of inverse agonists of angiotensin II type 1 receptor in stabilizing the inactive state. Molecular Endocrinology (Baltimore, Md.). 22: 139-46. PMID 17901125 DOI: 10.1210/me.2007-0312 |
0.415 |
|
| 2007 |
Senanayake Pd, Drazba J, Shadrach K, Milsted A, Rungger-Brandle E, Nishiyama K, Miura S, Karnik S, Sears JE, Hollyfield JG. Angiotensin II and its receptor subtypes in the human retina. Investigative Ophthalmology & Visual Science. 48: 3301-11. PMID 17591902 DOI: 10.1167/Iovs.06-1024 |
0.31 |
|
| 2007 |
Lee C, Hwang SA, Jang SH, Chung HS, Bhat MB, Karnik SS. Manifold active-state conformations in GPCRs: agonist-activated constitutively active mutant AT1 receptor preferentially couples to Gq compared to the wild-type AT1 receptor. Febs Letters. 581: 2517-22. PMID 17498700 DOI: 10.1016/j.febslet.2007.04.069 |
0.425 |
|
| 2006 |
Miura S, Fujino M, Hanzawa H, Kiya Y, Imaizumi S, Matsuo Y, Tomita S, Uehara Y, Karnik SS, Yanagisawa H, Koike H, Komuro I, Saku K. Molecular mechanism underlying inverse agonist of angiotensin II type 1 receptor. The Journal of Biological Chemistry. 281: 19288-95. PMID 16690611 DOI: 10.1074/jbc.M602144200 |
0.447 |
|
| 2006 |
Baleanu-Gogonea C, Karnik S. Model of the whole rat AT1 receptor and the ligand-binding site. Journal of Molecular Modeling. 12: 325-37. PMID 16404618 DOI: 10.1007/S00894-005-0049-Z |
0.48 |
|
| 2005 |
Feng YH, Ding Y, Ren S, Zhou L, Xu C, Karnik SS. Unconventional homologous internalization of the angiotensin II type-1 receptor induced by G-protein-independent signals. Hypertension. 46: 419-25. PMID 15998700 DOI: 10.1161/01.HYP.0000172621.68061.22 |
0.448 |
|
| 2005 |
Perez DM, Karnik SS. Multiple signaling states of G-protein-coupled receptors. Pharmacological Reviews. 57: 147-61. PMID 15914464 DOI: 10.1124/pr.57.2.2 |
0.38 |
|
| 2005 |
Miura S, Karnik SS, Saku K. Constitutively active homo-oligomeric angiotensin II type 2 receptor induces cell signaling independent of receptor conformation and ligand stimulation. The Journal of Biological Chemistry. 280: 18237-44. PMID 15746093 DOI: 10.1074/jbc.M500639200 |
0.442 |
|
| 2004 |
Miura S, Zhang J, Matsuo Y, Saku K, Karnik SS. Activation of extracellular signal-activated kinase by angiotensin II-induced Gq-independent epidermal growth factor receptor transactivation. Hypertension Research : Official Journal of the Japanese Society of Hypertension. 27: 765-70. PMID 15785012 DOI: JST.JSTAGE/hypres/27.765 |
0.307 |
|
| 2004 |
Pucadyil TJ, Kalipatnapu S, Harikumar KG, Rangaraj N, Karnik SS, Chattopadhyay A. G-protein-dependent cell surface dynamics of the human serotonin1A receptor tagged to yellow fluorescent protein. Biochemistry. 43: 15852-62. PMID 15595840 DOI: 10.1021/Bi0480887 |
0.427 |
|
| 2004 |
Takezako T, Gogonea C, Saad Y, Noda K, Karnik SS. "Network leaning" as a mechanism of insurmountable antagonism of the angiotensin II type 1 receptor by non-peptide antagonists. The Journal of Biological Chemistry. 279: 15248-57. PMID 14754891 DOI: 10.1074/Jbc.M312728200 |
0.394 |
|
| 2003 |
Miura S, Saku K, Karnik SS. Molecular analysis of the structure and function of the angiotensin II type 1 receptor. Hypertension Research : Official Journal of the Japanese Society of Hypertension. 26: 937-43. PMID 14717335 DOI: 10.1291/hypres.26.937 |
0.466 |
|
| 2003 |
Karnik SS, Gogonea C, Patil S, Saad Y, Takezako T. Activation of G-protein-coupled receptors: a common molecular mechanism. Trends in Endocrinology and Metabolism: Tem. 14: 431-7. PMID 14580763 DOI: 10.1016/J.Tem.2003.09.007 |
0.349 |
|
| 2003 |
Miura S, Zhang J, Boros J, Karnik SS. TM2-TM7 interaction in coupling movement of transmembrane helices to activation of the angiotensin II type-1 receptor. The Journal of Biological Chemistry. 278: 3720-5. PMID 12446719 DOI: 10.1074/jbc.M211338200 |
0.329 |
|
| 2002 |
Miura S, Karnik SS. Constitutive activation of angiotensin II type 1 receptor alters the orientation of transmembrane Helix-2. The Journal of Biological Chemistry. 277: 24299-305. PMID 11983705 DOI: 10.1074/jbc.M202743200 |
0.367 |
|
| 2002 |
Holloway AC, Qian H, Pipolo L, Ziogas J, Miura S, Karnik S, Southwell BR, Lew MJ, Thomas WG. Side-chain substitutions within angiotensin II reveal different requirements for signaling, internalization, and phosphorylation of type 1A angiotensin receptors. Molecular Pharmacology. 61: 768-77. PMID 11901215 DOI: 10.1124/MOL.61.4.768 |
0.393 |
|
| 2002 |
Karnik SS. Analysis of structure-function from expression of G protein-coupled receptor fragments. Methods in Enzymology. 343: 248-59. PMID 11665571 DOI: 10.1016/S0076-6879(02)43140-0 |
0.345 |
|
| 2000 |
Feng YH, Saad Y, Karnik SS. Reversible inactivation of AT2 angiotensin II receptor from cysteine-disulfide bond exchange Febs Letters. 484: 133-138. PMID 11068047 DOI: 10.1016/S0014-5793(00)02141-4 |
0.339 |
|
| 2000 |
Miura S, Karnik SS. Ligand-independent signals from angiotensin II type 2 receptor induce apoptosis. The Embo Journal. 19: 4026-35. PMID 10921883 DOI: 10.1093/emboj/19.15.4026 |
0.439 |
|
| 2000 |
Thomas WG, Qian HW, Chang C, Karnik S. Agonist-induced phosphorylation of the angiotensin II (AT(1A)) receptor requires generation of a conformation that is distinct from the inositol phosphate-signaling state. Journal of Biological Chemistry. 275: 2893-2900. PMID 10644757 DOI: 10.1074/Jbc.275.4.2893 |
0.521 |
|
| 2000 |
Ramchandran R, Barrett-Stull L, Wilk D, Vince G, Miura S, Zhang J, Boros J, Husain A, Moravec C, Karnik S. Attenuated Angiotensin Ii-Response in Transgenic Mice Expressing the At1 Receptor in the Vascular Endothelial Cells. Hypertension. 36: 727-727. DOI: 10.1161/01.Hyp.36.Suppl_1.727 |
0.345 |
|
| 1999 |
Feng YH, Karnik SS. Role of transmembrane helix IV in G-protein specificity of the angiotensin II type 1 receptor. The Journal of Biological Chemistry. 274: 35546-52. PMID 10585429 DOI: 10.1074/jbc.274.50.35546 |
0.418 |
|
| 1999 |
Miura S, Karnik SS. Angiotensin II type 1 and type 2 receptors bind angiotensin II through different types of epitope recognition. Journal of Hypertension. 17: 397-404. PMID 10100078 DOI: 10.1097/00004872-199917030-00013 |
0.403 |
|
| 1999 |
Miura S, Feng YH, Husain A, Karnik SS. Role of aromaticity of agonist switches of angiotensin II in the activation of the AT1 receptor. The Journal of Biological Chemistry. 274: 7103-10. PMID 10066768 DOI: 10.1074/jbc.274.11.7103 |
0.377 |
|
| 1998 |
Feng YH, Miura S, Husain A, Karnik SS. Mechanism of constitutive activation of the AT1 receptor: influence of the size of the agonist switch binding residue Asn(111). Biochemistry. 37: 15791-8. PMID 9843384 DOI: 10.1021/bi980863t |
0.344 |
|
| 1996 |
Karnik SS, Husain A, Graham RM. Molecular determinants of peptide and non-peptide binding to the AT1 receptor. Clinical and Experimental Pharmacology & Physiology. 23: S58-66. PMID 21143275 DOI: 10.1111/j.1440-1681.1996.tb02815.x |
0.45 |
|
| 1995 |
Feng YH, Noda K, Saad Y, Liu XP, Husain A, Karnik SS. The docking of Arg2 of angiotensin II with Asp281 of AT1 receptor is essential for full agonism. The Journal of Biological Chemistry. 270: 12846-50. PMID 7759541 DOI: 10.1074/Jbc.270.21.12846 |
0.403 |
|
| 1995 |
Noda K, Saad Y, Kinoshita A, Boyle TP, Graham RM, Husain A, Karnik SS. Tetrazole and carboxylate groups of angiotensin receptor antagonists bind to the same subsite by different mechanisms. The Journal of Biological Chemistry. 270: 2284-9. PMID 7530721 DOI: 10.1074/Jbc.270.5.2284 |
0.317 |
|
| 1995 |
Noda K, Saad Y, Karnik SS. Interaction of Phe8 of angiotensin II with Lys199 and His256 of AT1 receptor in agonist activation Journal of Biological Chemistry. 270: 28511-28514. PMID 7499361 DOI: 10.1074/Jbc.270.48.28511 |
0.369 |
|
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