| Year |
Citation |
Score |
| 2023 |
Onyedibe KI, Mohallem R, Wang M, Aryal UK, Sintim HO. Proteomic and phosphoproteomic analyses of Jurkat T-cell treated with 2'3' cGAMP reveals various signaling axes impacted by cyclic dinucleotides. Journal of Proteomics. 279: 104869. PMID 36889538 DOI: 10.1016/j.jprot.2023.104869 |
0.656 |
|
| 2021 |
Wang M, Chaudhuri R, Ong WWS, Sintim HO. c-di-GMP Induces COX-2 Expression in Macrophages in a STING-Independent Manner. Acs Chemical Biology. PMID 34478263 DOI: 10.1021/acschembio.1c00342 |
0.665 |
|
| 2020 |
Dayal N, Wang M, Sintim HO. HSD1787, a Tetrahydro-3-Pyrazolo[4,3-]Quinoline Compound Synthesized via Povarov Reaction, Potently Inhibits Proliferation of Cancer Cell Lines at Nanomolar Concentrations. Acs Omega. 5: 23799-23807. PMID 32984700 DOI: 10.1021/acsomega.0c03001 |
0.64 |
|
| 2020 |
Aryal UK, Hedrick V, Onyedibe KI, Sobreira TJP, Sooreshjani MA, Wang M, Gürsoy UK, Sintim HO. Global Proteomic Analyses of STING-Positive and -Negative Macrophages Reveal STING and Non-STING Differentially Regulated Cellular and Molecular Pathways. Proteomics. Clinical Applications. e1900109. PMID 32065729 DOI: 10.1002/Prca.201900109 |
0.703 |
|
| 2020 |
Huff K, Sintim H, Lescun T, Figueiredo ML. Effect of Novel Molecules Against Inflammation in Lipopolysaccharide (LPS)‐Stimulated Fibroblast‐Like Synoviocytes (FLS) The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.03509 |
0.601 |
|
| 2019 |
Sintim HO, Mikek CG, Wang M, Sooreshjani MA. Interrupting cyclic dinucleotide-cGAS-STING axis with small molecules. Medchemcomm. 10: 1999-2023. PMID 32206239 DOI: 10.1039/C8Md00555A |
0.758 |
|
| 2019 |
Onyedibe KI, Wang M, Sintim HO. ENPP1, an Old Enzyme with New Functions, and Small Molecule Inhibitors-A STING in the Tale of ENPP1. Molecules (Basel, Switzerland). 24. PMID 31752288 DOI: 10.3390/Molecules24224192 |
0.683 |
|
| 2019 |
Dayal N, Opoku-Temeng C, Mohammad H, Abutaleb NS, Hernandez D, Onyedibe KI, Wang M, Zeller M, Seleem MN, Sintim HO. Inhibitors of Intracellular Gram-positive Bacteria Growth Synthesized via Povarov-Doebner Reactions. Acs Infectious Diseases. PMID 31512848 DOI: 10.1021/Acsinfecdis.9B00022 |
0.683 |
|
| 2019 |
Dayal N, Mikek CG, Hernandez D, Naclerio GA, Yin Chu EF, Carter-Cooper BA, Lapidus RG, Sintim HO. Potently inhibiting cancer cell migration with novel 3H-pyrazolo[4,3-f]quinoline boronic acid ROCK inhibitors. European Journal of Medicinal Chemistry. 180: 449-456. PMID 31330446 DOI: 10.1016/J.Ejmech.2019.06.089 |
0.77 |
|
| 2019 |
Sintim HO, Al Mamari HH, Almohseni HAA, Fegheh-Hassanpour Y, Hodgson DM. Alkylation of lithiated dimethyl tartrate acetonide with unactivated alkyl halides and application to an asymmetric synthesis of the 2,8-dioxabicyclo[3.2.1]octane core of squalestatins/zaragozic acids. Beilstein Journal of Organic Chemistry. 15: 1194-1202. PMID 31293666 DOI: 10.3762/Bjoc.15.116 |
0.479 |
|
| 2019 |
Wang M, Naganna N, Sintim HO. Identification of nicotinamide aminonaphthyridine compounds as potent RET kinase inhibitors and antitumor activities against RET rearranged lung adenocarcinoma. Bioorganic Chemistry. 90: 103052. PMID 31226468 DOI: 10.1016/J.Bioorg.2019.103052 |
0.671 |
|
| 2019 |
Opoku-Temeng C, Onyedibe KI, Aryal UK, Sintim HO. Proteomic analysis of bacterial response to a 4-hydroxybenzylidene indolinone compound, which re-sensitizes bacteria to traditional antibiotics. Journal of Proteomics. PMID 31028946 DOI: 10.1016/J.Jprot.2019.04.018 |
0.324 |
|
| 2019 |
Robinson SM, Shen Z, Askim JR, Montgomery CB, Sintim HO, Semancik S. Ligand-Based Stability Changes in Duplex DNA Measured with a Microscale Electrochemical Platform. Biosensors. 9. PMID 31013753 DOI: 10.3390/Bios9020054 |
0.324 |
|
| 2019 |
Sintim HO, Naclerio GA, Karanja CW, Opoku-Temeng C. Antibacterial small molecules that potently inhibit Staphylococcus aureus lipoteichoic acid biosynthesis. Chemmedchem. PMID 30939229 DOI: 10.1002/Cmdc.201900053 |
0.317 |
|
| 2019 |
Naganna N, Opoku-Temeng C, Choi EY, Larocque E, Chang ET, Carter-Cooper BA, Wang M, Torregrosa-Allen SE, Elzey BD, Lapidus RG, Sintim HO. Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice. Ebiomedicine. PMID 30686755 DOI: 10.1016/J.Ebiom.2019.01.012 |
0.65 |
|
| 2019 |
Elmanfi S, Zhou J, Sintim HO, Könönen E, Gürsoy M, Gürsoy UK. Regulation of gingival epithelial cytokine response by bacterial cyclic dinucleotides. Journal of Oral Microbiology. 11: 1538927. PMID 30598733 DOI: 10.1080/20002297.2018.1538927 |
0.332 |
|
| 2019 |
Sintim HO, Valade A, Harling DC, Hodgson DM. Squarate desymmetrisation–ozonolysis as an approach to β-substituted-α-ketosuccinates and squalestatin synthesis Tetrahedron. 75: 130747. DOI: 10.1016/J.Tet.2019.130747 |
0.441 |
|
| 2018 |
Wang M, Sintim HO. Discriminating cyclic from linear nucleotides - CRISPR/Cas-related cyclic hexaadenosine monophosphate as a case study. Analytical Biochemistry. 567: 21-26. PMID 30502320 DOI: 10.1016/J.Ab.2018.11.022 |
0.66 |
|
| 2018 |
Mikek CG, West SJ, Gwin JC, Dayal N, Sintim HO, Lewis EA. Berenil Binds Tightly to Parallel and Mixed Parallel/Antiparallel G-Quadruplex Motifs with Varied Thermodynamic Signatures. Acs Omega. 3: 11582-11591. PMID 30320266 DOI: 10.1021/acsomega.8b01621 |
0.77 |
|
| 2018 |
Ilina P, Ma X, Sintim HO, Tammela P. Miniaturized whole-cell bacterial bioreporter assay for identification of quorum-sensing interfering compounds. Journal of Microbiological Methods. PMID 30300658 DOI: 10.1016/J.Mimet.2018.10.005 |
0.323 |
|
| 2018 |
Fegheh-Hassanpour Y, Arif T, Sintim HO, Al Mamari HH, Hodgson DM. Correction to Synthesis of (-)-6,7-Dideoxysqualestatin H5 by Carbonyl Ylide Cycloaddition-Rearrangement and Cross-electrophile Coupling. Organic Letters. PMID 30125117 DOI: 10.1021/Acs.Orglett.8B02330 |
0.442 |
|
| 2018 |
Ha JH, Hauk P, Cho K, Eo Y, Ma X, Stephens K, Cha S, Jeong M, Suh JY, Sintim HO, Bentley WE, Ryu KS. Evidence of link between quorum sensing and sugar metabolism in revealed via cocrystal structures of LsrK and HPr. Science Advances. 4: eaar7063. PMID 29868643 DOI: 10.1126/Sciadv.Aar7063 |
0.323 |
|
| 2018 |
Almohseni HAA, Al Mamari HH, Valade A, Sintim HO, Hodgson DM. Alkene protection against acid using a bromide substituent: application in a total synthesis of (-)-6,7-dideoxysqualestatin H5. Chemical Communications (Cambridge, England). PMID 29741545 DOI: 10.1039/C8Cc02690D |
0.488 |
|
| 2018 |
Opoku-Temeng C, Dayal N, Aflaki Sooreshjani M, Sintim HO. 3H-pyrazolo[4,3-f]quinoline haspin kinase inhibitors and anticancer properties. Bioorganic Chemistry. 78: 418-426. PMID 29698892 DOI: 10.1016/J.Bioorg.2018.03.031 |
0.32 |
|
| 2018 |
Opoku-Temeng C, Dayal N, Hernandez DE, Naganna N, Sintim HO. Tetrahydro-3H-pyrazolo[4,3-a]phenanthridine-based CDK inhibitor. Chemical Communications (Cambridge, England). PMID 29629444 DOI: 10.1039/C8Cc01154K |
0.305 |
|
| 2018 |
Fegheh-Hassanpour Y, Ebrahim F, Arif T, Sintim HO, Claridge TDW, Amin NT, Hodgson DM. On the ozonolysis of unsaturated tosylhydrazones as a direct approach to diazocarbonyl compounds. Organic & Biomolecular Chemistry. PMID 29611856 DOI: 10.1039/C8Ob00435H |
0.476 |
|
| 2018 |
Wang M, Sooreshjani MA, Mikek C, Opoku-Temeng C, Sintim HO. Suramin potently inhibits cGAMP synthase, cGAS, in THP1 cells to modulate IFN-β levels. Future Medicinal Chemistry. PMID 29558821 DOI: 10.4155/Fmc-2017-0322 |
0.76 |
|
| 2018 |
Sintim HO, Aman MJ, Holtsberg F, Emadi A, Lapidus RG. KRX-101, a Novel FLT3 Inhibitor, Potently Active Against Resistant FLT3-ITD/FLT3-TKD Mutant AML in Vitro and In Vivo Blood. 132: 4049-4049. DOI: 10.1182/Blood-2018-99-115260 |
0.321 |
|
| 2018 |
Sooreshjani MA, Gursoy UK, Aryal UK, Sintim HO. Proteomic analysis of RAW macrophages treated with cGAMP or c-di-GMP reveals differentially activated cellular pathways Rsc Advances. 8: 36840-36851. DOI: 10.1039/C8Ra04603D |
0.309 |
|
| 2017 |
Opoku-Temeng C, Sintim HO. Targeting c-di-GMP Signaling, Biofilm Formation, and Bacterial Motility with Small Molecules. Methods in Molecular Biology (Clifton, N.J.). 1657: 419-430. PMID 28889311 DOI: 10.1007/978-1-4939-7240-1_31 |
0.363 |
|
| 2017 |
Zhou J, Opoku-Temeng C, Sintim HO. Fluorescent 2-Aminopurine c-di-GMP and GpG Analogs as PDE Probes. Methods in Molecular Biology (Clifton, N.J.). 1657: 245-261. PMID 28889299 DOI: 10.1007/978-1-4939-7240-1_19 |
0.337 |
|
| 2017 |
Fteita D, Musrati AA, Könönen E, Ma X, Gürsoy M, Peurla M, Söderling E, Sintim HO, Gürsoy UK. Dipeptidyl peptidase IV and quorum sensing signaling in biofilm-related virulence of Prevotella aurantiaca. Anaerobe. PMID 28821458 DOI: 10.1016/J.Anaerobe.2017.08.009 |
0.301 |
|
| 2017 |
Gürsoy UK, Gürsoy M, Könönen E, Sintim HO. Cyclic Dinucleotides in Oral Bacteria and in Oral Biofilms. Frontiers in Cellular and Infection Microbiology. 7: 273. PMID 28680857 DOI: 10.3389/Fcimb.2017.00273 |
0.313 |
|
| 2017 |
Fegheh-Hassanpour Y, Arif T, Sintim HO, Al Mamari HH, Hodgson DM. Synthesis of (-)-6,7-Dideoxysqualestatin H5 by Carbonyl Ylide Cycloaddition-Rearrangement and Cross-electrophile Coupling. Organic Letters. PMID 28631488 DOI: 10.1021/Acs.Orglett.7B01513 |
0.479 |
|
| 2017 |
Dey RJ, Dey B, Zheng Y, Cheung LS, Zhou J, Sayre D, Kumar P, Guo H, Lamichhane G, Sintim HO, Bishai WR. Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase. Nature Chemical Biology. 13: 210-217. PMID 28106876 DOI: 10.1038/Nchembio.2254 |
0.312 |
|
| 2017 |
Opoku-Temeng C, Dayal N, Miller J, Sintim HO. Hydroxybenzylidene-indolinones, c-di-AMP synthase inhibitors, have antibacterial and anti-biofilm activities and also re-sensitize resistant bacteria to methicillin and vancomycin Rsc Advances. 7: 8288-8294. DOI: 10.1039/C6Ra28443D |
0.35 |
|
| 2017 |
Zhou J, Zheng Y, Roembke BT, Robinson SM, Opoku-Temeng C, Sayre DA, Sintim HO. Fluorescent analogs of cyclic and linear dinucleotides as phosphodiesterase and oligoribonuclease activity probes Rsc Advances. 7: 5421-5426. DOI: 10.1039/C6Ra25394F |
0.343 |
|
| 2016 |
Zheng Y, Tsuji G, Opoku-Temeng C, Sintim HO. Inhibition of c-di-GMP phosphodiesterase RocR and swarming motility by a benzoisothiazolinone derivative. Chemical Science. 7: 6238-6244. PMID 30034764 DOI: 10.1039/C6Sc02103D |
0.398 |
|
| 2016 |
Hauk P, Stephens K, Mckay R, Virgile CR, Ueda H, Ostermeier M, Ryu KS, Sintim HO, Bentley WE. Insightful directed evolution of Escherichia coli quorum sensing promoter region of the lsrACDBFG operon: a tool for synthetic biology systems and protein expression. Nucleic Acids Research. 44: 10515-10525. PMID 27915294 DOI: 10.1093/Nar/Gkw981 |
0.302 |
|
| 2016 |
Zhou J, Roembke BT, Paragi G, Laguerre A, Sintim HO, Fonseca Guerra C, Monchaud D. Computational understanding and experimental characterization of twice-as-smart quadruplex ligands as chemical sensors of bacterial nucleotide second messengers. Scientific Reports. 6: 33888. PMID 27667717 DOI: 10.1038/Srep33888 |
0.346 |
|
| 2016 |
Opoku-Temeng C, Zhou J, Zheng Y, Su J, Sintim HO. Cyclic dinucleotide (c-di-GMP, c-di-AMP, and cGAMP) signalings have come of age to be inhibited by small molecules. Chemical Communications (Cambridge, England). PMID 27339003 DOI: 10.1039/C6Cc03439J |
0.389 |
|
| 2016 |
Opoku-Temeng C, Sintim HO. Inhibition of cyclic diadenylate cyclase, DisA, by polyphenols. Scientific Reports. 6: 25445. PMID 27150552 DOI: 10.1038/Srep25445 |
0.383 |
|
| 2016 |
Wang C, Carter-Cooper B, Du Y, Zhou J, Saeed MA, Liu J, Guo M, Roembke B, Mikek C, Lewis EA, Lapidus RG, Sintim HO. Alkyne-substituted diminazene as G-quadruplex binders with anticancer activities. European Journal of Medicinal Chemistry. 118: 266-275. PMID 27132164 DOI: 10.1016/J.Ejmech.2016.04.030 |
0.779 |
|
| 2016 |
Opoku-Temeng C, Sintim HO. Potent inhibition of cyclic diadenylate monophosphate cyclase by the antiparasitic drug, suramin. Chemical Communications (Cambridge, England). PMID 26824279 DOI: 10.1039/C5Cc10446G |
0.345 |
|
| 2016 |
Tsuji G, Sintim HO. Cyclic dinucleotide detection with riboswitch-G-quadruplex hybrid. Molecular Biosystems. PMID 26739090 DOI: 10.1039/C5Mb00751H |
0.307 |
|
| 2015 |
Orr MW, Donaldson GP, Severin GB, Wang J, Sintim HO, Waters CM, Lee VT. Oligoribonuclease is the primary degradative enzyme for pGpG in Pseudomonas aeruginosa that is required for cyclic-di-GMP turnover. Proceedings of the National Academy of Sciences of the United States of America. 112: E5048-57. PMID 26305945 DOI: 10.1073/Pnas.1507245112 |
0.365 |
|
| 2015 |
Zargar A, Quan DN, Carter KK, Guo M, Sintim HO, Payne GF, Bentley WE. Bacterial secretions of nonpathogenic Escherichia coli elicit inflammatory pathways: a closer investigation of interkingdom signaling. Mbio. 6: e00025. PMID 25759496 DOI: 10.1128/Mbio.00025-15 |
0.34 |
|
| 2015 |
Gordon ON, Luis PB, Sintim HO, Schneider C. Unraveling curcumin degradation: autoxidation proceeds through spiroepoxide and vinylether intermediates en route to the main bicyclopentadione. The Journal of Biological Chemistry. 290: 4817-28. PMID 25564617 DOI: 10.1074/Jbc.M114.618785 |
0.302 |
|
| 2015 |
Guo M, Zheng Y, Starks R, Opoku-Temeng C, Ma X, Sintim HO. 3-Aminooxazolidinone AHL analogs as hydrolytically-stable quorum sensing agonists in Gram-negative bacteria Medchemcomm. 6: 1086-1092. DOI: 10.1039/C5Md00015G |
0.382 |
|
| 2015 |
Zheng Y, Zhou J, Cooper SM, Opoku-Temeng C, De Brito AM, Sintim HO. Structure-activity relationship studies of c-di-AMP synthase inhibitor, bromophenol-thiohydantoin Tetrahedron. DOI: 10.1016/J.Tet.2015.10.073 |
0.39 |
|
| 2014 |
Zheng Y, Sintim HO. Molecular insights into how ligands activate or inactivate LasR. Chemistry & Biology. 21: 1261-3. PMID 25373343 DOI: 10.1016/J.Chembiol.2014.10.001 |
0.303 |
|
| 2014 |
Zheng Y, Zhou J, Sayre DA, Sintim HO. Identification of bromophenol thiohydantoin as an inhibitor of DisA, a c-di-AMP synthase, from a 1000 compound library, using the coralyne assay. Chemical Communications (Cambridge, England). 50: 11234-7. PMID 25116237 DOI: 10.1039/C4Cc02916J |
0.385 |
|
| 2014 |
Zhou J, Le V, Kalia D, Nakayama S, Mikek C, Lewis EA, Sintim HO. Diminazene or berenil, a classic duplex minor groove binder, binds to G-quadruplexes with low nanomolar dissociation constants and the amidine groups are also critical for G-quadruplex binding. Molecular Biosystems. 10: 2724-34. PMID 25096593 DOI: 10.1039/C4Mb00359D |
0.728 |
|
| 2014 |
Roembke BT, Zhou J, Zheng Y, Sayre D, Lizardo A, Bernard L, Sintim HO. A cyclic dinucleotide containing 2-aminopurine is a general fluorescent sensor for c-di-GMP and 3',3'-cGAMP. Molecular Biosystems. 10: 1568-75. PMID 24705858 DOI: 10.1039/C3Mb70518H |
0.337 |
|
| 2014 |
Zhou J, Sayre DA, Zheng Y, Szmacinski H, Sintim HO. Unexpected complex formation between coralyne and cyclic diadenosine monophosphate providing a simple fluorescent turn-on assay to detect this bacterial second messenger. Analytical Chemistry. 86: 2412-20. PMID 24494631 DOI: 10.1021/Ac403203X |
0.364 |
|
| 2014 |
Luo Y, Chen B, Zhou J, Sintim HO, Dayie TK. E88, a new cyclic-di-GMP class I riboswitch aptamer from Clostridium tetani, has a similar fold to the prototypical class I riboswitch, Vc2, but differentially binds to c-di-GMP analogs. Molecular Biosystems. 10: 384-90. PMID 24430255 DOI: 10.1039/C3Mb70467J |
0.323 |
|
| 2014 |
Adams BL, Carter KK, Guo M, Wu HC, Tsao CY, Sintim HO, Valdes JJ, Bentley WE. Evolved Quorum sensing regulator, LsrR, for altered switching functions. Acs Synthetic Biology. 3: 210-9. PMID 24111753 DOI: 10.1021/Sb400068Z |
0.31 |
|
| 2013 |
Roembke BT, Nakayama S, Sintim HO. Nucleic acid detection using G-quadruplex amplification methodologies. Methods (San Diego, Calif.). 64: 185-98. PMID 24135042 DOI: 10.1016/J.Ymeth.2013.10.003 |
0.308 |
|
| 2013 |
Ha JH, Eo Y, Grishaev A, Guo M, Smith JA, Sintim HO, Kim EH, Cheong HK, Bentley WE, Ryu KS. Crystal structures of the LsrR proteins complexed with phospho-AI-2 and two signal-interrupting analogues reveal distinct mechanisms for ligand recognition. Journal of the American Chemical Society. 135: 15526-35. PMID 24047255 DOI: 10.1021/Ja407068V |
0.361 |
|
| 2013 |
Sintim HO, Nakayama S. Detection of single-stranded nucleic acids via colorimetric means, using G-quadruplex probes. Methods in Molecular Biology (Clifton, N.J.). 1039: 153-9. PMID 24026694 DOI: 10.1007/978-1-62703-535-4_13 |
0.316 |
|
| 2013 |
Guo M, Gamby S, Zheng Y, Sintim HO. Small molecule inhibitors of AI-2 signaling in bacteria: state-of-the-art and future perspectives for anti-quorum sensing agents. International Journal of Molecular Sciences. 14: 17694-728. PMID 23994835 DOI: 10.3390/Ijms140917694 |
0.311 |
|
| 2013 |
Kalia D, Merey G, Guo M, Sintim HO. N-O tethered carbenoid cyclopropanation facilitates the synthesis of a functionalized cyclopropyl-fused pyrrolidine. The Journal of Organic Chemistry. 78: 6131-42. PMID 23701258 DOI: 10.1021/Jo400788A |
0.738 |
|
| 2013 |
Zhou J, Watt S, Wang J, Nakayama S, Sayre DA, Lam YF, Lee VT, Sintim HO. Potent suppression of c-di-GMP synthesis via I-site allosteric inhibition of diguanylate cyclases with 2'-F-c-di-GMP. Bioorganic & Medicinal Chemistry. 21: 4396-404. PMID 23685177 DOI: 10.1016/J.Bmc.2013.04.050 |
0.383 |
|
| 2013 |
Luo Y, Zhou J, Wang J, Dayie TK, Sintim HO. Selective binding of 2'-F-c-di-GMP to Ct-E88 and Cb-E43, new class I riboswitches from Clostridium tetani and Clostridium botulinum respectively. Molecular Biosystems. 9: 1535-9. PMID 23559271 DOI: 10.1039/C3Mb25560C |
0.324 |
|
| 2013 |
Roy V, Meyer MT, Smith JA, Gamby S, Sintim HO, Ghodssi R, Bentley WE. AI-2 analogs and antibiotics: a synergistic approach to reduce bacterial biofilms. Applied Microbiology and Biotechnology. 97: 2627-38. PMID 23053069 DOI: 10.1007/S00253-012-4404-6 |
0.313 |
|
| 2013 |
Kalia D, Merey G, Nakayama S, Zheng Y, Zhou J, Luo Y, Guo M, Roembke BT, Sintim HO. Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp signaling in bacteria and implications in pathogenesis. Chemical Society Reviews. 42: 305-41. PMID 23023210 DOI: 10.1039/C2Cs35206K |
0.768 |
|
| 2013 |
Roembke BT, Wang J, Nakayama S, Zhou J, Sintim HO. Octameric G8 c-di-GMP is an efficient peroxidase and this suggests that an open G-tetrad site can effectively enhance hemin peroxidation reactions Rsc Advances. 3: 6305-6310. DOI: 10.1039/C3Ra23308A |
0.379 |
|
| 2012 |
Zhou J, Sayre DA, Wang J, Pahadi N, Sintim HO. Endo-S-c-di-GMP analogues-polymorphism and binding studies with class I riboswitch. Molecules (Basel, Switzerland). 17: 13376-89. PMID 23143150 DOI: 10.3390/Molecules171113376 |
0.377 |
|
| 2012 |
Nakayama S, Luo Y, Zhou J, Dayie TK, Sintim HO. Nanomolar fluorescent detection of c-di-GMP using a modular aptamer strategy. Chemical Communications (Cambridge, England). 48: 9059-61. PMID 22854718 DOI: 10.1039/C2Cc34379G |
0.309 |
|
| 2012 |
Guo M, Gamby S, Nakayama S, Smith J, Sintim HO. A pro-drug approach for selective modulation of AI-2-mediated bacterial cell-to-cell communication. Sensors (Basel, Switzerland). 12: 3762-72. PMID 22737036 DOI: 10.3390/S120303762 |
0.316 |
|
| 2012 |
Gamby S, Roy V, Guo M, Smith JA, Wang J, Stewart JE, Wang X, Bentley WE, Sintim HO. Altering the communication networks of multispecies microbial systems using a diverse toolbox of AI-2 analogues. Acs Chemical Biology. 7: 1023-30. PMID 22433054 DOI: 10.1021/Cb200524Y |
0.358 |
|
| 2012 |
Nakayama S, Roelofs K, Lee VT, Sintim HO. A C-di-GMP-proflavine-hemin supramolecular complex has peroxidase activity--implication for a simple colorimetric detection. Molecular Biosystems. 8: 726-9. PMID 22252690 DOI: 10.1039/C2Mb05430B |
0.341 |
|
| 2012 |
Kelsey I, Nakayama S, Sintim HO. Diamidinium and iminium aromatics as new aggregators of the bacterial signaling molecule, c-di-GMP. Bioorganic & Medicinal Chemistry Letters. 22: 881-5. PMID 22217869 DOI: 10.1016/J.Bmcl.2011.12.039 |
0.372 |
|
| 2012 |
Donaldson GP, Roelofs KG, Luo Y, Sintim HO, Lee VT. A rapid assay for affinity and kinetics of molecular interactions with nucleic acids. Nucleic Acids Research. 40: e48. PMID 22210888 DOI: 10.1093/Nar/Gkr1299 |
0.334 |
|
| 2012 |
Luo Y, Zhou J, Watt SK, Lee VT, Dayie TK, Sintim HO. Differential binding of 2'-biotinylated analogs of c-di-GMP with c-di-GMP riboswitches and binding proteins. Molecular Biosystems. 8: 772-8. PMID 22182995 DOI: 10.1039/C2Mb05338A |
0.359 |
|
| 2011 |
Wang J, Zhou J, Donaldson GP, Nakayama S, Yan L, Lam YF, Lee VT, Sintim HO. Conservative change to the phosphate moiety of cyclic diguanylic monophosphate remarkably affects its polymorphism and ability to bind DGC, PDE, and PilZ proteins. Journal of the American Chemical Society. 133: 9320-30. PMID 21612220 DOI: 10.1021/Ja1112029 |
0.379 |
|
| 2011 |
Nakayama S, Wang J, Sintim HO. DNA-based peroxidation catalyst--what is the exact role of topology on catalysis and is there a special binding site for catalysis? Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 5691-8. PMID 21469226 DOI: 10.1002/Chem.201002349 |
0.317 |
|
| 2011 |
Nakayama S, Kelsey I, Wang J, Sintim HO. c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators. Chemical Communications (Cambridge, England). 47: 4766-8. PMID 21399808 DOI: 10.1039/C0Cc05432A |
0.381 |
|
| 2011 |
Nakayama S, Kelsey I, Wang J, Roelofs K, Stefane B, Luo Y, Lee VT, Sintim HO. Thiazole orange-induced c-di-GMP quadruplex formation facilitates a simple fluorescent detection of this ubiquitous biofilm regulating molecule. Journal of the American Chemical Society. 133: 4856-64. PMID 21384923 DOI: 10.1021/Ja1091062 |
0.38 |
|
| 2010 |
Sintim HO, Smith JA, Wang J, Nakayama S, Yan L. Paradigm shift in discovering next-generation anti-infective agents: targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules. Future Medicinal Chemistry. 2: 1005-35. PMID 21426116 DOI: 10.4155/Fmc.10.185 |
0.335 |
|
| 2010 |
Roy V, Smith JA, Wang J, Stewart JE, Bentley WE, Sintim HO. Synthetic analogs tailor native AI-2 signaling across bacterial species. Journal of the American Chemical Society. 132: 11141-50. PMID 20698680 DOI: 10.1021/Ja102587W |
0.351 |
|
| 2010 |
Wang J, Stefane B, Jaber D, Smith JA, Vickery C, Diop M, Sintim HO. Remote C-H functionalization: using the N-O moiety as an atom-economical tether to obtain 1,5- and the rare 1,7-C-H insertions. Angewandte Chemie (International Ed. in English). 49: 3964-8. PMID 20401885 DOI: 10.1002/Anie.201000160 |
0.756 |
|
| 2009 |
Jarchow-Choy SK, Sjuvarsson E, Sintim HO, Eriksson S, Kool ET. Nonpolar nucleoside mimics as active substrates for human thymidine kinases. Journal of the American Chemical Society. 131: 5488-94. PMID 20560637 DOI: 10.1021/Ja808244T |
0.51 |
|
| 2009 |
Smith JA, Wang J, Nguyen-Mau SM, Lee V, Sintim HO. Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous. Chemical Communications (Cambridge, England). 7033-5. PMID 19904385 DOI: 10.1039/B909666C |
0.305 |
|
| 2009 |
Nakayama S, Sintim HO. Colorimetric split G-quadruplex probes for nucleic acid sensing: improving reconstituted DNAzyme's catalytic efficiency via probe remodeling. Journal of the American Chemical Society. 131: 10320-33. PMID 19621970 DOI: 10.1021/Ja902951B |
0.33 |
|
| 2009 |
Wang J, Lee V, Sintim HO. Efforts towards the identification of simpler platensimycin analogues--the total synthesis of oxazinidinyl platensimycin. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 2747-50. PMID 19212990 DOI: 10.1002/Chem.200802568 |
0.313 |
|
| 2009 |
Sintim HO, Kool ET. Enhanced base pairing and replication efficiency of thiothymidines, expanded-size variants of thymidine (Journal of the American Chemical Society (2006) 128, (396-397)) Journal of the American Chemical Society. 131: 11270. DOI: 10.1021/ja905423u |
0.378 |
|
| 2008 |
Kiburu I, Shurer A, Yan L, Sintim HO. A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues. Molecular Biosystems. 4: 518-20. PMID 18493648 DOI: 10.1039/B719423D |
0.365 |
|
| 2006 |
Kool ET, Sintim HO. The difluorotoluene debate--a decade later. Chemical Communications (Cambridge, England). 3665-75. PMID 17047807 DOI: 10.1039/B605414E |
0.478 |
|
| 2006 |
Sintim HO, Kool ET. Remarkable sensitivity to DNA base shape in the DNA polymerase active site. Angewandte Chemie (International Ed. in English). 45: 1974-9. PMID 16506248 DOI: 10.1002/Anie.200504296 |
0.482 |
|
| 2006 |
Sintim HO, Kool ET. Enhanced base pairing and replication efficiency of thiothymidines, expanded-size variants of thymidine. Journal of the American Chemical Society. 128: 396-7. PMID 16402811 DOI: 10.1021/Ja0562447 |
0.483 |
|
| 2005 |
Donohoe TJ, Sintim HO, Hollinshead J. A noncarbohydrate based approach to polyhydroxylated pyrrolidizines: total syntheses of the natural products hyacinthacine A1 and 1-epiaustraline. The Journal of Organic Chemistry. 70: 7297-304. PMID 16122251 DOI: 10.1021/Jo050977S |
0.532 |
|
| 2005 |
Donohoe TJ, Sintim HO, Sisangia L, Ace KW, Guyo PM, Cowley A, Harling JD. Utility of the ammonia-free Birch reduction of electron-deficient pyrroles: total synthesis of the 20s proteasome inhibitor, clasto-lactacystin beta-lactone. Chemistry (Weinheim An Der Bergstrasse, Germany). 11: 4227-38. PMID 15864801 DOI: 10.1002/Chem.200401119 |
0.55 |
|
| 2004 |
Donohoe TJ, Sintim HO. A concise total synthesis of (+/-)-1-epiaustraline. Organic Letters. 6: 2003-6. PMID 15176804 DOI: 10.1021/Ol049397S |
0.545 |
|
| 2004 |
Donohoe TJ, Sintim HO, Sisangia L, Harling JD. An efficient synthesis of lactacystin beta-lactone. Angewandte Chemie (International Ed. in English). 43: 2293-6. PMID 15108149 DOI: 10.1002/Anie.200453843 |
0.482 |
|
| 2004 |
Donohoe TJ, Sintim HO, Sisangia L, Harling JD. An Efficient Synthesis of Lactacystinβ-Lactone Angewandte Chemie. 116: 2343-2346. DOI: 10.1002/Ange.200453843 |
0.503 |
|
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