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Andrew Scharenberg - Publications

Affiliations: 
Immunology University of Washington, Seattle, Seattle, WA 
Area:
Molecular Biology, Biochemistry, Immunology
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45 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Schmidt MJ, Gupta A, Bednarski C, Gehrig-Giannini S, Richter F, Pitzler C, Gamalinda M, Galonska C, Takeuchi R, Wang K, Reiss C, Dehne K, Lukason MJ, Noma A, Park-Windhol C, ... ... Scharenberg AM, et al. Improved CRISPR genome editing using small highly active and specific engineered RNA-guided nucleases. Nature Communications. 12: 4219. PMID 34244505 DOI: 10.1038/s41467-021-24454-5  0.355
2019 Pattabhi S, Lotti SN, Berger MP, Singh S, Lux CT, Jacoby K, Lee C, Negre O, Scharenberg AM, Rawlings DJ. In Vivo Outcome of Homology-Directed Repair at the HBB Gene in HSC Using Alternative Donor Template Delivery Methods. Molecular Therapy. Nucleic Acids. 17: 277-288. PMID 31279229 DOI: 10.1016/J.Omtn.2019.05.025  0.792
2019 Lux CT, Pattabhi S, Berger M, Nourigat C, Flowers DA, Negre O, Humbert O, Yang JG, Lee C, Jacoby K, Bernstein I, Kiem HP, Scharenberg A, Rawlings DJ. TALEN-Mediated Gene Editing of in Human Hematopoietic Stem Cells Leads to Therapeutic Fetal Hemoglobin Induction. Molecular Therapy. Methods & Clinical Development. 12: 175-183. PMID 30705922 DOI: 10.1016/J.Omtm.2018.12.008  0.764
2017 Lux CT, Scharenberg AM. Therapeutic Gene Editing Safety and Specificity. Hematology/Oncology Clinics of North America. 31: 787-795. PMID 28895847 DOI: 10.1016/j.hoc.2017.05.002  0.404
2017 Shaw KL, Garabedian E, Mishra S, Barman P, Davila A, Carbonaro D, Shupien S, Silvin C, Geiger S, Nowicki B, Smogorzewska EM, Brown B, Wang X, de Oliveira S, Choi Y, ... ... Scharenberg A, et al. Clinical efficacy of gene-modified stem cells in adenosine deaminase-deficient immunodeficiency. The Journal of Clinical Investigation. PMID 28346229 DOI: 10.1172/Jci90367  0.314
2017 Jacoby K, Lambert AR, Scharenberg AM. Characterization of homing endonuclease binding and cleavage specificities using yeast surface display SELEX (YSD-SELEX). Nucleic Acids Research. 45: e11. PMID 28180328 DOI: 10.1093/Nar/Gkw864  0.793
2016 Jacoby K, Lambert AR, Scharenberg AM. Characterization of homing endonuclease binding and cleavage specificities using yeast surface display SELEX (YSD-SELEX). Nucleic Acids Research. PMID 27683221 DOI: 10.1093/nar/gkw864  0.413
2016 Gwiazda KS, Grier AE, Sahni J, Burleigh SM, Martin U, Yang JG, Popp NA, Krutein MC, Khan IF, Jacoby K, Jensen MC, Rawlings DJ, Scharenberg AM. High efficiency CRISPR/Cas9-mediated gene editing in primary human T-cells using mutant adenoviral E4orf6/E1b55k "helper" proteins. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 27203437 DOI: 10.1038/Mt.2016.105  0.756
2016 Lambert AR, Hallinan JP, Shen BW, Chik JK, Bolduc JM, Kulshina N, Robins LI, Kaiser BK, Jarjour J, Havens K, Scharenberg AM, Stoddard BL. Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity. Structure (London, England : 1993). PMID 27133026 DOI: 10.1016/J.Str.2016.03.024  0.459
2016 Grier AE, Burleigh S, Sahni J, Clough CA, Cardot V, Choe DC, Krutein MC, Rawlings DJ, Jensen MC, Scharenberg AM, Jacoby K. pEVL: A Linear Plasmid for Generating mRNA IVT Templates With Extended Encoded Poly(A) Sequences. Molecular Therapy. Nucleic Acids. 5: e306. PMID 27093168 DOI: 10.1038/Mtna.2016.21  0.747
2016 Hubbard N, Hagin D, Sommer K, Song Y, Khan I, Clough C, Ochs HD, Rawlings DJ, Scharenberg AM, Torgerson TR. Targeted gene editing restores regulated CD40L expression and function in X-HIGM T cells. Blood. PMID 26903548 DOI: 10.1182/blood-2015-11-683235  0.324
2016 Chan F, Humbert O, Burtner C, Humphrys D, Adair J, Trobridge G, O'Donnell P, Hubbard N, Torgerson T, Scharenberg A, Rawlings D, Felsburg PJ, Kiem H. 284. Long-Term Therapeutic Immune Reconstitution in XSCID Canine Model via In Vivo Foamy Virus Delivery of Common Gamma Chain Molecular Therapy. 24: S114. DOI: 10.1016/S1525-0016(16)33093-3  0.386
2015 Sather BD, Romano Ibarra GS, Sommer K, Curinga G, Hale M, Khan IF, Singh S, Song Y, Gwiazda K, Sahni J, Jarjour J, Astrakhan A, Wagner TA, Scharenberg AM, Rawlings DJ. Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template. Science Translational Medicine. 7: 307ra156. PMID 26424571 DOI: 10.1126/Scitranslmed.Aac5530  0.778
2015 Corrigan-Curay J, O'Reilly M, Kohn DB, Cannon PM, Bao G, Bushman FD, Carroll D, Cathomen T, Joung JK, Roth D, Sadelain M, Scharenberg AM, von Kalle C, Zhang F, Jambou R, et al. Genome editing technologies: defining a path to clinic. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 796-806. PMID 25943494 DOI: 10.1038/Mt.2015.54  0.304
2015 Boissel S, Scharenberg AM. Assembly and characterization of megaTALs for hyperspecific genome engineering applications. Methods in Molecular Biology (Clifton, N.J.). 1239: 171-96. PMID 25408406 DOI: 10.1007/978-1-4939-1862-1_9  0.373
2015 Hubbard N, Song Y, Hagin D, Sommer K, Scharenberg A, Torgerson T, Rawlings D. 482. Editing of the CD40L Gene Restores Regulated CD40L Expression in X-HIGM Patient T Cells Molecular Therapy. 23. DOI: 10.1016/S1525-0016(16)34091-6  0.433
2014 Galetto R, Lebuhotel C, Poirot L, Gouble A, Toribio ML, Smith J, Scharenberg A. Pre-TCRα supports CD3-dependent reactivation and expansion of TCRα-deficient primary human T-cells. Molecular Therapy. Methods & Clinical Development. 1: 14021. PMID 26015965 DOI: 10.1038/Mtm.2014.21  0.324
2014 Scharenberg A. Gene targeting with nucleases: capped templates, semper fidelis? Nature Methods. 11: 1029-30. PMID 25264781 DOI: 10.1038/Nmeth.3110  0.463
2014 Wang Y, Khan IF, Boissel S, Jarjour J, Pangallo J, Thyme S, Baker D, Scharenberg AM, Rawlings DJ. Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus. Nucleic Acids Research. 42: 6463-75. PMID 24682825 DOI: 10.1093/Nar/Gku224  0.456
2014 Baxter SK, Scharenberg AM, Lambert AR. Engineering and flow-cytometric analysis of chimeric LAGLIDADG homing endonucleases from homologous I-OnuI-family enzymes. Methods in Molecular Biology (Clifton, N.J.). 1123: 191-221. PMID 24510269 DOI: 10.1007/978-1-62703-968-0_14  0.387
2014 Jacoby K, Scharenberg AM. Homing endonuclease target determination using SELEX adapted for yeast surface display. Methods in Molecular Biology (Clifton, N.J.). 1123: 165-90. PMID 24510268 DOI: 10.1007/978-1-62703-968-0_13  0.798
2014 Aubert M, Boyle NM, Stone D, Stensland L, Huang ML, Magaret AS, Galetto R, Rawlings DJ, Scharenberg AM, Jerome KR. In vitro Inactivation of Latent HSV by Targeted Mutagenesis Using an HSV-specific Homing Endonuclease. Molecular Therapy. Nucleic Acids. 3: e146. PMID 24496438 DOI: 10.1038/mtna.2013.75  0.347
2014 Boissel S, Jarjour J, Astrakhan A, Adey A, Gouble A, Duchateau P, Shendure J, Stoddard BL, Certo MT, Baker D, Scharenberg AM. MegaTALs: A rare-cleaving nuclease architecture for therapeutic genome engineering Nucleic Acids Research. 42: 2591-2601. PMID 24285304 DOI: 10.1093/Nar/Gkt1224  0.789
2014 Kuhar R, Gwiazda KS, Humbert O, Mandt T, Pangallo J, Brault M, Khan I, Maizels N, Rawlings DJ, Scharenberg AM, Certo MT. Novel fluorescent genome editing reporters for monitoring DNA repair pathway utilization at endonuclease-induced breaks. Nucleic Acids Research. 42: e4. PMID 24121685 DOI: 10.1093/Nar/Gkt872  0.783
2013 Scharenberg AM, Duchateau P, Smith J. Genome engineering with TAL-effector nucleases and alternative modular nuclease technologies Current Gene Therapy. 13: 291-303. PMID 23888878 DOI: 10.2174/15665232113139990026  0.397
2013 Eyquem J, Poirot L, Galetto R, Scharenberg AM, Smith J. Characterization of three loci for homologous gene targeting and transgene expression. Biotechnology and Bioengineering. 110: 2225-35. PMID 23475535 DOI: 10.1002/bit.24892  0.351
2013 Baxter SK, Lambert AR, Scharenberg AM, Jarjour J. Flow cytometric assays for interrogating LAGLIDADG homing endonuclease DNA-binding and cleavage properties. Methods in Molecular Biology (Clifton, N.J.). 978: 45-61. PMID 23423888 DOI: 10.1007/978-1-62703-293-3_4  0.442
2013 Mannioui CS, Lemaire L, Poirot L, Gouble A, Arnould S, Galetto R, Smith J, Scharenberg A. Treatment of B cells malignancies with anti-CD19 CAR+, TCR-, CD52- allogeneic T cells Journal For Immunotherapy of Cancer. 1: 34. DOI: 10.1186/2051-1426-1-S1-P34  0.329
2013 Poirot L, Schiffer-Mannioui C, Philip B, Derniame S, Gouble A, Chion-Sotinel I, Clerre DL, Lemaire L, Grosse S, Cheung G, Arnould S, Smith J, Pule M, Scharenberg A. T-Cell Engineering For “off-The-shelf” Adoptive Immunotherapy Blood. 122: 1661-1661. DOI: 10.1182/Blood.V122.21.1661.1661  0.357
2013 Poirot L, Chion-Sotinel I, Smith J, Scharenberg A, Clerre DL. T-cell engineering for adoptive immunotherapy using tal-effector nucleases (TALEN) Cytotherapy. 15. DOI: 10.1016/J.Jcyt.2013.01.145  0.305
2012 Certo MT, Gwiazda KS, Kuhar R, Sather B, Curinga G, Mandt T, Brault M, Lambert AR, Baxter SK, Jacoby K, Ryu BY, Kiem HP, Gouble A, Paques F, Rawlings DJ, ... Scharenberg AM, et al. Coupling endonucleases with DNA end-processing enzymes to drive gene disruption. Nature Methods. 9: 973-5. PMID 22941364 DOI: 10.1038/Nmeth.2177  0.733
2012 Ramirez CL, Certo MT, Mussolino C, Goodwin MJ, Cradick TJ, McCaffrey AP, Cathomen T, Scharenberg AM, Joung JK. Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects. Nucleic Acids Research. 40: 5560-8. PMID 22373919 DOI: 10.1093/Nar/Gks179  0.79
2012 Jacoby K, Metzger M, Shen BW, Certo MT, Jarjour J, Stoddard BL, Scharenberg AM. Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space. Nucleic Acids Research. 40: 4954-64. PMID 22334611 DOI: 10.1093/Nar/Gkr1303  0.784
2012 Muñoz NM, Beard BC, Ryu BY, Luche RM, Trobridge GD, Rawlings DJ, Scharenberg AM, Kiem HP. Novel reporter systems for facile evaluation of I-SceI-mediated genome editing. Nucleic Acids Research. 40: e14. PMID 22110042 DOI: 10.1093/Nar/Gkr897  0.402
2011 Takeuchi R, Lambert AR, Mak AN, Jacoby K, Dickson RJ, Gloor GB, Scharenberg AM, Edgell DR, Stoddard BL. Tapping natural reservoirs of homing endonucleases for targeted gene modification. Proceedings of the National Academy of Sciences of the United States of America. 108: 13077-82. PMID 21784983 DOI: 10.1073/Pnas.1107719108  0.823
2011 Certo MT, Ryu BY, Annis JE, Garibov M, Jarjour J, Rawlings DJ, Scharenberg AM. Tracking genome engineering outcome at individual DNA breakpoints. Nature Methods. 8: 671-6. PMID 21743461 DOI: 10.1038/nmeth.1648  0.769
2011 Aubert M, Ryu BY, Banks L, Rawlings DJ, Scharenberg AM, Jerome KR. Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI. Plos One. 6: e16825. PMID 21399673 DOI: 10.1371/journal.pone.0016825  0.389
2010 Paddock MN, Buelow BD, Takeda S, Scharenberg AM. The BRCT domain of PARP-1 is required for immunoglobulin gene conversion. Plos Biology. 8: e1000428. PMID 20652015 DOI: 10.1371/journal.pbio.1000428  0.401
2010 Rémy S, Tesson L, Ménoret S, Usal C, Scharenberg AM, Anegon I. Zinc-finger nucleases: a powerful tool for genetic engineering of animals. Transgenic Research. 19: 363-71. PMID 19821047 DOI: 10.1007/s11248-009-9323-7  0.341
2009 Thyme SB, Jarjour J, Takeuchi R, Havranek JJ, Ashworth J, Scharenberg AM, Stoddard BL, Baker D. Exploitation of binding energy for catalysis and design. Nature. 461: 1300-4. PMID 19865174 DOI: 10.1038/Nature08508  0.359
2009 Jarjour J, West-Foyle H, Certo MT, Hubert CG, Doyle L, Getz MM, Stoddard BL, Scharenberg AM. High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display. Nucleic Acids Research. 37: 6871-80. PMID 19740766 DOI: 10.1093/Nar/Gkp726  0.776
2009 Buelow B, Uzunparmak B, Paddock M, Scharenberg AM. Structure/function analysis of PARP-1 in oxidative and nitrosative stress-induced monomeric ADPR formation. Plos One. 4: e6339. PMID 19641624 DOI: 10.1371/journal.pone.0006339  0.306
2009 Takeuchi R, Certo M, Caprara MG, Scharenberg AM, Stoddard BL. Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation. Nucleic Acids Research. 37: 877-90. PMID 19103658 DOI: 10.1093/Nar/Gkn1007  0.75
2007 Volná P, Jarjour J, Baxter S, Roffler SR, Monnat RJ, Stoddard BL, Scharenberg AM. Flow cytometric analysis of DNA binding and cleavage by cell surface-displayed homing endonucleases. Nucleic Acids Research. 35: 2748-58. PMID 17426121 DOI: 10.1093/Nar/Gkm182  0.437
2003 Shen BW, Perraud AL, Scharenberg A, Stoddard BL. The crystal structure and mutational analysis of human NUDT9. Journal of Molecular Biology. 332: 385-98. PMID 12948489 DOI: 10.1016/S0022-2836(03)00954-9  0.304
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