Jeffrey L. Wrana - Publications

Affiliations: 
University of Toronto, Toronto, ON, Canada 
Area:
Cell Biology, Molecular Biology

139 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Yanchus C, Drucker KL, Kollmeyer TM, Tsai R, Winick-Ng W, Liang M, Malik A, Pawling J, De Lorenzo SB, Ali A, Decker PA, Kosel ML, Panda A, Al-Zahrani KN, Jiang L, ... ... Wrana J, et al. A noncoding single-nucleotide polymorphism at 8q24 drives -mutant glioma formation. Science (New York, N.Y.). 378: 68-78. PMID 36201590 DOI: 10.1126/science.abj2890  0.529
2022 Zhang T, He X, Caldwell L, Goru SK, Ulloa Severino L, Tolosa MF, Misra PS, McEvoy CM, Christova T, Liu Y, Atin C, Zhang J, Hu C, Vukosa N, Chen X, ... ... Wrana JL, et al. NUAK1 promotes organ fibrosis via YAP and TGF-β/SMAD signaling. Science Translational Medicine. 14: eaaz4028. PMID 35320001 DOI: 10.1126/scitranslmed.aaz4028  0.615
2021 Kagiwada S, Aramaki S, Wu G, Shin B, Kutejova E, Obridge D, Adachi K, Wrana JL, Hübner K, Schöler HR. YAP creates epiblast responsiveness to inductive signals for germ cell fate. Development (Cambridge, England). PMID 34528691 DOI: 10.1242/dev.199732  0.31
2021 Pearson JD, Trcka D, Lu S, Hyduk SJ, Jen M, Aynaud MM, Hernández JJ, Peidis P, Barrios-Rodiles M, Chan K, Woodgett J, Mazzulli T, Attisano L, Pelletier L, Cybulsky MI, ... Wrana JL, et al. Comparison of SARS-CoV-2 indirect and direct RT-qPCR detection methods. Virology Journal. 18: 99. PMID 34001180 DOI: 10.1186/s12985-021-01574-4  0.499
2021 Aynaud MM, Hernandez JJ, Barutcu S, Braunschweig U, Chan K, Pearson JD, Trcka D, Prosser SL, Kim J, Barrios-Rodiles M, Jen M, Song S, Shen J, Bruce C, Hazlett B, ... ... Wrana JL, et al. A multiplexed, next generation sequencing platform for high-throughput detection of SARS-CoV-2. Nature Communications. 12: 1405. PMID 33658502 DOI: 10.1038/s41467-021-21653-y  0.512
2020 Isho B, Abe KT, Zuo M, Jamal AJ, Rathod B, Wang JH, Li Z, Chao G, Rojas OL, Bang YM, Pu A, Christie-Holmes N, Gervais C, Ceccarelli D, Samavarchi-Tehrani P, ... ... Wrana JL, et al. Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients. Science Immunology. 5. PMID 33033173 DOI: 10.1126/sciimmunol.abe5511  0.657
2020 Labibi B, Bashkurov M, Wrana JL, Attisano L. Modeling the Control of TGF-β/Smad Nuclear Accumulation by the Hippo Pathway Effectors, Taz/Yap. Iscience. 23: 101416. PMID 32798968 DOI: 10.1016/J.Isci.2020.101416  0.605
2020 Sivitilli AA, Gosio JT, Ghoshal B, Evstratova A, Trcka D, Ghiasi P, Hernandez JJ, Beaulieu JM, Wrana JL, Attisano L. Robust production of uniform human cerebral organoids from pluripotent stem cells. Life Science Alliance. 3. PMID 32303588 DOI: 10.26508/lsa.202000707  0.569
2018 Gill MK, Christova T, Zhang YY, Gregorieff A, Zhang L, Narimatsu M, Song S, Xiong S, Couzens AL, Tong J, Krieger JR, Moran MF, Zlotta AR, van der Kwast TH, Gingras AC, ... ... Wrana JL, et al. A feed forward loop enforces YAP/TAZ signaling during tumorigenesis. Nature Communications. 9: 3510. PMID 30158528 DOI: 10.1038/S41467-018-05939-2  0.619
2017 Tassew NG, Charish J, Shabanzadeh AP, Luga V, Harada H, Farhani N, D'Onofrio P, Choi B, Ellabban A, Nickerson PEB, Wallace VA, Koeberle PD, Wrana JL, Monnier PP. Exosomes Mediate Mobilization of Autocrine Wnt10b to Promote Axonal Regeneration in the Injured CNS. Cell Reports. 20: 99-111. PMID 28683327 DOI: 10.1016/J.Celrep.2017.06.009  0.764
2017 Ayyaz A, Attisano L, Wrana JL. Recent advances in understanding contextual TGFβ signaling. F1000research. 6: 749. PMID 28649369 DOI: 10.12688/F1000Research.11295.1  0.631
2017 Gregorieff A, Wrana JL. Hippo signalling in intestinal regeneration and cancer. Current Opinion in Cell Biology. 48: 17-25. PMID 28527754 DOI: 10.1016/j.ceb.2017.04.005  0.314
2016 Campbell CI, Samavarchi-Tehrani P, Barrios-Rodiles M, Datti A, Gingras AC, Wrana JL. The RNF146/Tankyrase pathway maintains the junctional Crumbs complex through regulation of Angiomotin. Journal of Cell Science. PMID 27521426 DOI: 10.1242/Jcs.188417  0.715
2016 Zhang L, Luga V, Armitage SK, Musiol M, Won A, Yip CM, Plotnikov SV, Wrana JL. A lateral signalling pathway coordinates shape volatility during cell migration. Nature Communications. 7: 11714. PMID 27226243 DOI: 10.1038/Ncomms11714  0.805
2016 Narimatsu M, Labibi B, Wrana JL, Attisano L. Analysis of Hippo and TGFβ signaling in polarizing epithelial cells and mouse embryos. Differentiation; Research in Biological Diversity. 91: 109-18. PMID 26803209 DOI: 10.1016/J.Diff.2016.01.003  0.645
2015 Campbell JE, Ussher JR, Mulvihill EE, Kolic J, Baggio LL, Cao X, Liu Y, Lamont BJ, Morii T, Streutker CJ, Tamarina N, Philipson LH, Wrana JL, MacDonald PE, Drucker DJ. TCF1 links GIPR signaling to the control of beta cell function and survival. Nature Medicine. PMID 26642437 DOI: 10.1038/Nm.3997  0.313
2015 Gregorieff A, Liu Y, Inanlou MR, Khomchuk Y, Wrana JL. Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer. Nature. 526: 715-8. PMID 26503053 DOI: 10.1038/nature15382  0.303
2015 Cassar PA, Carpenedo RL, Samavarchi-Tehrani P, Olsen JB, Park CJ, Chang WY, Chen Z, Choey C, Delaney S, Guo H, Guo H, Tanner RM, Perkins TJ, Tenenbaum SA, Emili A, ... Wrana JL, et al. Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network. Embo Reports. 16: 1334-57. PMID 26265008 DOI: 10.15252/Embr.201540974  0.715
2015 Lee EA, Angka L, Rota SG, Hanlon T, Mitchell A, Hurren R, Wang XM, Gronda M, Boyaci E, Bojko B, Minden M, Sriskanthadevan S, Datti A, Wrana JL, Edginton A, et al. Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death. Cancer Research. 75: 2478-88. PMID 26077472 DOI: 10.1158/0008-5472.Can-14-2676  0.305
2015 Narimatsu M, Samavarchi-Tehrani P, Varelas X, Wrana JL. Distinct polarity cues direct Taz/Yap and TGFβ receptor localization to differentially control TGFβ-induced Smad signaling. Developmental Cell. 32: 652-6. PMID 25758863 DOI: 10.1016/J.Devcel.2015.02.019  0.773
2014 Shimoda M, Principe S, Jackson HW, Luga V, Fang H, Molyneux SD, Shao YW, Aiken A, Waterhouse PD, Karamboulas C, Hess FM, Ohtsuka T, Okada Y, Ailles L, Ludwig A, ... Wrana JL, et al. Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state. Nature Cell Biology. 16: 889-901. PMID 25150980 DOI: 10.1038/Ncb3021  0.792
2014 Xu G, Barrios-Rodiles M, Jerkic M, Turinsky AL, Nadon R, Vera S, Voulgaraki D, Wrana JL, Toporsian M, Letarte M. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Molecular & Cellular Proteomics : McP. 13: 489-502. PMID 24319055 DOI: 10.1074/Mcp.M113.033464  0.334
2013 Beyer TA, Weiss A, Khomchuk Y, Huang K, Ogunjimi AA, Varelas X, Wrana JL. Switch enhancers interpret TGF-β and Hippo signaling to control cell fate in human embryonic stem cells. Cell Reports. 5: 1611-24. PMID 24332857 DOI: 10.1016/j.celrep.2013.11.021  0.326
2013 Luga V, Wrana JL. Tumor-stroma interaction: Revealing fibroblast-secreted exosomes as potent regulators of Wnt-planar cell polarity signaling in cancer metastasis. Cancer Research. 73: 6843-7. PMID 24265274 DOI: 10.1158/0008-5472.Can-13-1791  0.799
2013 Attisano L, Wrana JL. Signal integration in TGF-β, WNT, and Hippo pathways. F1000prime Reports. 5: 17. PMID 23755364 DOI: 10.12703/P5-17  0.628
2013 Han H, Irimia M, Ross PJ, Sung HK, Alipanahi B, David L, Golipour A, Gabut M, Michael IP, Nachman EN, Wang E, Trcka D, Thompson T, O'Hanlon D, Slobodeniuc V, ... ... Wrana JL, et al. MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Nature. 498: 241-5. PMID 23739326 DOI: 10.1038/Nature12270  0.794
2012 Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL. Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. Cell. 151: 1542-56. PMID 23260141 DOI: 10.1016/J.Cell.2012.11.024  0.798
2012 Golipour A, David L, Liu Y, Jayakumaran G, Hirsch CL, Trcka D, Wrana JL. A late transition in somatic cell reprogramming requires regulators distinct from the pluripotency network. Cell Stem Cell. 11: 769-82. PMID 23217423 DOI: 10.1016/J.Stem.2012.11.008  0.775
2012 Attisano L, Wrana JL. The return of Dr Jekyll in cancer metastasis. The Embo Journal. 31: 4486-7. PMID 23188084 DOI: 10.1038/Emboj.2012.316  0.586
2012 Klüppel M, Samavarchi-Tehrani P, Liu K, Wrana JL, Hinek A. C4ST-1/CHST11-controlled chondroitin sulfation interferes with oncogenic HRAS signaling in Costello syndrome. European Journal of Human Genetics : Ejhg. 20: 870-7. PMID 22317973 DOI: 10.1038/Ejhg.2012.12  0.721
2011 David L, Samavarchi-Tehrani P, Golipour A, Wrana JL. Looking into the black box: insights into the mechanisms of somatic cell reprogramming. Genes. 2: 81-106. PMID 24710139 DOI: 10.3390/Genes2010081  0.768
2011 Varelas X, Wrana JL. Coordinating developmental signaling: novel roles for the Hippo pathway. Trends in Cell Biology. 22: 88-96. PMID 22153608 DOI: 10.1016/j.tcb.2011.10.002  0.33
2011 Skrti? M, Sriskanthadevan S, Jhas B, Gebbia M, Wang X, Wang Z, Hurren R, Jitkova Y, Gronda M, Maclean N, Lai CK, Eberhard Y, Bartoszko J, Spagnuolo P, Rutledge AC, ... ... Wrana J, et al. Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell. 20: 674-88. PMID 22094260 DOI: 10.1016/J.Ccr.2011.10.015  0.301
2011 Song S, Christova T, Perusini S, Alizadeh S, Bao RY, Miller BW, Hurren R, Jitkova Y, Gronda M, Isaac M, Joseph B, Subramaniam R, Aman A, Chau A, Hogge DE, ... ... Wrana JL, et al. Wnt inhibitor screen reveals iron dependence of β-catenin signaling in cancers. Cancer Research. 71: 7628-39. PMID 22009536 DOI: 10.1158/0008-5472.Can-11-2745  0.658
2011 Gabut M, Samavarchi-Tehrani P, Wang X, Slobodeniuc V, O'Hanlon D, Sung HK, Alvarez M, Talukder S, Pan Q, Mazzoni EO, Nedelec S, Wichterle H, Woltjen K, Hughes TR, Zandstra PW, ... ... Wrana JL, et al. An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 147: 132-46. PMID 21924763 DOI: 10.1016/J.Cell.2011.08.023  0.726
2011 Mao X, Cao B, Wood TE, Hurren R, Tong J, Wang X, Wang W, Li J, Jin Y, Sun W, Spagnuolo PA, MacLean N, Moran MF, Datti A, Wrana J, et al. A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway. Blood. 117: 1986-97. PMID 21135258 DOI: 10.1182/Blood-2010-05-284810  0.307
2010 Varelas X, Samavarchi-Tehrani P, Narimatsu M, Weiss A, Cockburn K, Larsen BG, Rossant J, Wrana JL. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Developmental Cell. 19: 831-44. PMID 21145499 DOI: 10.1016/J.Devcel.2010.11.012  0.761
2010 Samavarchi-Tehrani P, Golipour A, David L, Sung HK, Beyer TA, Datti A, Woltjen K, Nagy A, Wrana JL. Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell. 7: 64-77. PMID 20621051 DOI: 10.1016/J.Stem.2010.04.015  0.779
2010 Gumienny TL, Macneil L, Zimmerman CM, Wang H, Chin L, Wrana JL, Padgett RW. Caenorhabditis elegans SMA-10/LRIG is a conserved transmembrane protein that enhances bone morphogenetic protein signaling. Plos Genetics. 6: e1000963. PMID 20502686 DOI: 10.1371/journal.pgen.1000963  0.331
2010 Varelas X, Miller BW, Sopko R, Song S, Gregorieff A, Fellouse FA, Sakuma R, Pawson T, Hunziker W, McNeill H, Wrana JL, Attisano L. The Hippo pathway regulates Wnt/beta-catenin signaling. Developmental Cell. 18: 579-91. PMID 20412773 DOI: 10.1016/J.Devcel.2010.03.007  0.672
2010 Garamszegi N, Garamszegi SP, Samavarchi-Tehrani P, Walford E, Schneiderbauer MM, Wrana JL, Scully SP. Extracellular matrix-induced transforming growth factor-beta receptor signaling dynamics. Oncogene. 29: 2368-80. PMID 20101206 DOI: 10.1038/Onc.2009.514  0.785
2009 Miller BW, Lau G, Grouios C, Mollica E, Barrios-Rodiles M, Liu Y, Datti A, Morris Q, Wrana JL, Attisano L. Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway. Molecular Systems Biology. 5: 315. PMID 19888210 DOI: 10.1038/Msb.2009.72  0.628
2009 Narimatsu M, Bose R, Pye M, Zhang L, Miller B, Ching P, Sakuma R, Luga V, Roncari L, Attisano L, Wrana JL. Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell. 137: 295-307. PMID 19379695 DOI: 10.1016/J.Cell.2009.02.025  0.794
2009 Luga V, McLean S, Le Roy C, O'Connor-McCourt M, Wrana JL, Di Guglielmo GM. The extracellular domain of the TGFbeta type II receptor regulates membrane raft partitioning. The Biochemical Journal. 421: 119-31. PMID 19356148 DOI: 10.1042/Bj20081131  0.783
2009 MacNeil LT, Hardy WR, Pawson T, Wrana JL, Culotti JG. UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways. Nature Neuroscience. 12: 150-5. PMID 19169249 DOI: 10.1038/nn.2256  0.387
2008 Varelas X, Sakuma R, Samavarchi-Tehrani P, Peerani R, Rao BM, Dembowy J, Yaffe MB, Zandstra PW, Wrana JL. TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nature Cell Biology. 10: 837-48. PMID 18568018 DOI: 10.1038/Ncb1748  0.751
2008 Townsend TA, Wrana JL, Davis GE, Barnett JV. Transforming growth factor-beta-stimulated endocardial cell transformation is dependent on Par6c regulation of RhoA. The Journal of Biological Chemistry. 283: 13834-41. PMID 18343818 DOI: 10.1074/Jbc.M710607200  0.341
2008 Silvestri C, Narimatsu M, von Both I, Liu Y, Tan NB, Izzi L, McCaffery P, Wrana JL, Attisano L. Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development. Developmental Cell. 14: 411-23. PMID 18331719 DOI: 10.1016/J.Devcel.2008.01.004  0.589
2008 To C, Kulkarni S, Pawson T, Honda T, Gribble GW, Sporn MB, Wrana JL, Di Guglielmo GM. The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid-imidazolide alters transforming growth factor β-dependent signaling and cell migration by affecting the cytoskeleton and the polarity complex Journal of Biological Chemistry. 283: 11700-11713. PMID 18283107 DOI: 10.1074/Jbc.M704064200  0.373
2008 Groppe J, Hinck CS, Samavarchi-Tehrani P, Zubieta C, Schuermann JP, Taylor AB, Schwarz PM, Wrana JL, Hinck AP. Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding. Molecular Cell. 29: 157-68. PMID 18243111 DOI: 10.1016/J.Molcel.2007.11.039  0.767
2007 Mao X, Stewart AK, Hurren R, Datti A, Zhu X, Zhu Y, Shi C, Lee K, Tiedemann R, Eberhard Y, Trudel S, Liang S, Corey SJ, Gillis LC, Barber DL, ... Wrana JL, et al. A chemical biology screen identifies glucocorticoids that regulate c-maf expression by increasing its proteasomal degradation through up-regulation of ubiquitin. Blood. 110: 4047-54. PMID 17875808 DOI: 10.1182/Blood-2007-05-088666  0.305
2007 Izzi L, Silvestri C, von Both I, Labbé E, Zakin L, Wrana JL, Attisano L. Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. The Embo Journal. 26: 3132-43. PMID 17568773 DOI: 10.1038/Sj.Emboj.7601753  0.644
2007 Gumienny TL, MacNeil LT, Wang H, de Bono M, Wrana JL, Padgett RW. Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans. Current Biology : Cb. 17: 159-64. PMID 17240342 DOI: 10.1016/j.cub.2006.11.065  0.314
2006 Park HJ, Partridge E, Cheung P, Pawling J, Donovan R, Wrana JL, Dennis JW. Chemical enhancers of cytokine signaling that suppress microfilament turnover and tumor cell growth. Cancer Research. 66: 3558-66. PMID 16585180 DOI: 10.1158/0008-5472.CAN-05-2542  0.382
2006 Bose R, Wrana JL. Regulation of Par6 by extracellular signals. Current Opinion in Cell Biology. 18: 206-12. PMID 16490351 DOI: 10.1016/J.CEB.2006.02.005  0.319
2005 Ogunjimi AA, Briant DJ, Pece-Barbara N, Le Roy C, Di Guglielmo GM, Kavsak P, Rasmussen RK, Seet BT, Sicheri F, Wrana JL. Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain Molecular Cell. 19: 297-308. PMID 16061177 DOI: 10.1016/J.Molcel.2005.06.028  0.475
2005 Pece-Barbara N, Vera S, Kathirkamathamby K, Liebner S, Di Guglielmo GM, Dejana E, Wrana JL, Letarte M. Endoglin null endothelial cells proliferate faster and are more responsive to transforming growth factor beta1 with higher affinity receptors and an activated Alk1 pathway. The Journal of Biological Chemistry. 280: 27800-8. PMID 15923183 DOI: 10.1074/Jbc.M503471200  0.371
2005 Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, ... ... Wrana JL, et al. High-throughput mapping of a dynamic signaling network in mammalian cells. Science (New York, N.Y.). 307: 1621-5. PMID 15761153 DOI: 10.1126/Science.1105776  0.8
2005 Ozdamar B, Bose R, Barrios-Rodiles M, Wang HR, Zhang Y, Wrana JL. Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science (New York, N.Y.). 307: 1603-9. PMID 15761148 DOI: 10.1126/science.1105718  0.349
2005 Klüppel M, Wrana JL. Turning it up a Notch: cross-talk between TGF beta and Notch signaling. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 27: 115-8. PMID 15666349 DOI: 10.1002/bies.20187  0.381
2004 Lee-Hoeflich ST, Causing CG, Podkowa M, Zhao X, Wrana JL, Attisano L. Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis. The Embo Journal. 23: 4792-801. PMID 15538389 DOI: 10.1038/Sj.Emboj.7600418  0.632
2004 Partridge EA, Le Roy C, Di Guglielmo GM, Pawling J, Cheung P, Granovsky M, Nabi IR, Wrana JL, Dennis JW. Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis. Science (New York, N.Y.). 306: 120-4. PMID 15459394 DOI: 10.1126/science.1102109  0.302
2004 Swallow CJ, Partridge EA, Macmillan JC, Tajirian T, DiGuglielmo GM, Hay K, Szweras M, Jahnen-Dechent W, Wrana JL, Redston M, Gallinger S, Dennis JW. alpha2HS-glycoprotein, an antagonist of transforming growth factor beta in vivo, inhibits intestinal tumor progression. Cancer Research. 64: 6402-9. PMID 15374947 DOI: 10.1158/0008-5472.Can-04-1117  0.318
2004 von Both I, Silvestri C, Erdemir T, Lickert H, Walls JR, Henkelman RM, Rossant J, Harvey RP, Attisano L, Wrana JL. Foxh1 is essential for development of the anterior heart field. Developmental Cell. 7: 331-45. PMID 15363409 DOI: 10.1016/J.Devcel.2004.07.023  0.573
2004 Massagué J, Attisano L, Wrana JL. The TGF-beta family and its composite receptors. Trends in Cell Biology. 4: 172-8. PMID 14731645 DOI: 10.1016/0962-8924(94)90202-X  0.731
2004 Reguly T, Wrana JL. In or out? The dynamics of Smad nucleocytoplasmic shuttling. Trends in Cell Biology. 13: 216-20. PMID 12742164 DOI: 10.1016/S0962-8924(03)00075-8  0.789
2004 Viloria-Petit A, Ozdamar B, Bose R, Wang H, Barrios-Rodiles M, Zhang Y, Wrana J. 365 Identification of a novel TGF-beta-induced signaling cascade involved in EMT and invasion of breast cancer cells European Journal of Cancer Supplements. 2: 110. DOI: 10.1016/S1359-6349(04)80372-0  0.306
2003 Xiao C, Shim JH, Klüppel M, Zhang SS, Dong C, Flavell RA, Fu XY, Wrana JL, Hogan BL, Ghosh S. Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes & Development. 17: 2933-49. PMID 14633973 DOI: 10.1101/Gad.1145603  0.395
2003 Rebbapragada A, Benchabane H, Wrana JL, Celeste AJ, Attisano L. Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis. Molecular and Cellular Biology. 23: 7230-42. PMID 14517293 DOI: 10.1128/MCB.23.20.7230-7242.2003  0.695
2003 Benchabane H, Wrana JL. GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations. Molecular and Cellular Biology. 23: 6646-61. PMID 12944489 DOI: 10.1128/MCB.23.18.6646-6661.2003  0.353
2003 Di Guglielmo GM, Le Roy C, Goodfellow AF, Wrana JL. Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. Nature Cell Biology. 5: 410-21. PMID 12717440 DOI: 10.1038/ncb975  0.386
2002 Mehra A, Wrana JL. TGF-β and the Smad signal transduction pathway Biochemistry and Cell Biology. 80: 605-622. PMID 12440701 DOI: 10.1139/O02-161  0.34
2002 Attisano L, Wrana JL. Signal transduction by the TGF-beta superfamily. Science (New York, N.Y.). 296: 1646-7. PMID 12040180 DOI: 10.1126/Science.1071809  0.685
2002 Panopoulou E, Gillooly DJ, Wrana JL, Zerial M, Stenmark H, Murphy C, Fotsis T. Early endosomal regulation of Smad-dependent signaling in endothelial cells. The Journal of Biological Chemistry. 277: 18046-52. PMID 11877415 DOI: 10.1074/Jbc.M107983200  0.4
2002 Wrana JL. Phosphoserine-dependent regulation of protein-protein interactions in the Smad pathway. Structure (London, England : 1993). 10: 5-7. PMID 11796104 DOI: 10.1016/S0969-2126(01)00702-X  0.391
2001 Stroschein SL, Bonni S, Wrana JL, Luo K. Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN. Genes & Development. 15: 2822-36. PMID 11691834 DOI: 10.1101/Gad.912901  0.371
2001 Bonni S, Wang HR, Causing CG, Kavsak P, Stroschein SL, Luo K, Wrana JL. TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation. Nature Cell Biology. 3: 587-95. PMID 11389444 DOI: 10.1038/35078562  0.58
2001 Quinn ZA, Yang CC, Wrana JL, McDermott JC. Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins. Nucleic Acids Research. 29: 732-42. PMID 11160896 DOI: 10.1093/Nar/29.3.732  0.321
2000 Wrana JL. Crossing Smads. Science's Stke : Signal Transduction Knowledge Environment. 2000: re1. PMID 11752591 DOI: 10.1126/stke.2000.23.re1  0.429
2000 Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. Molecular Cell. 6: 1365-75. PMID 11163210 DOI: 10.1016/S1097-2765(00)00134-9  0.583
2000 Miura S, Takeshita T, Asao H, Kimura Y, Murata K, Sasaki Y, Hanai JI, Beppu H, Tsukazaki T, Wrana JL, Miyazono K, Sugamura K. Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA. Molecular and Cellular Biology. 20: 9346-55. PMID 11094085 DOI: 10.1128/MCB.20.24.9346-9355.2000  0.374
2000 Hua X, Miller ZA, Benchabane H, Wrana JL, Lodish HF. Synergism between transcription factors TFE3 and Smad3 in transforming growth factor-beta-induced transcription of the Smad7 gene. The Journal of Biological Chemistry. 275: 33205-8. PMID 10973944 DOI: 10.1074/Jbc.C000568200  0.326
2000 Sirard C, Kim S, Mirtsos C, Tadich P, Hoodless PA, Itié A, Maxson R, Wrana JL, Mak TW. Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling. The Journal of Biological Chemistry. 275: 2063-70. PMID 10636910 DOI: 10.1074/JBC.275.3.2063  0.414
1999 Zhu H, Kavsak P, Abdollah S, Wrana JL, Thomsen GH. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature. 400: 687-93. PMID 10458166 DOI: 10.1038/23293  0.635
1999 Hoodless PA, Tsukazaki T, Nishimatsu S, Attisano L, Wrana JL, Thomsen GH. Dominant-negative Smad2 mutants inhibit activin/Vg1 signaling and disrupt axis formation in Xenopus. Developmental Biology. 207: 364-79. PMID 10068469 DOI: 10.1006/Dbio.1998.9168  0.651
1999 Brummel T, Abdollah S, Haerry TE, Shimell MJ, Merriam J, Raftery L, Wrana JL, O'Connor MB. The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development. Genes & Development. 13: 98-111. PMID 9887103 DOI: 10.1101/GAD.13.1.98  0.449
1999 Barbara NP, Wrana JL, Letarte M. Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily. The Journal of Biological Chemistry. 274: 584-94. PMID 9872992 DOI: 10.1074/Jbc.274.2.584  0.354
1999 Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL. SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell. 95: 779-91. PMID 9865696 DOI: 10.1016/S0092-8674(00)81701-8  0.666
1998 Li J, Tsuji K, Komori T, Miyazono K, Wrana JL, Ito Y, Nifuji A, Noda M. Smad2 overexpression enhances Smad4 gene expression and suppresses CBFA1 gene expression in osteoblastic osteosarcoma ROS17/2.8 cells and primary rat calvaria cells. The Journal of Biological Chemistry. 273: 31009-15. PMID 9812998 DOI: 10.1074/JBC.273.47.31009  0.385
1998 Macías-Silva M, Hoodless PA, Tang SJ, Buchwald M, Wrana JL. Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. The Journal of Biological Chemistry. 273: 25628-36. PMID 9748228 DOI: 10.1074/Jbc.273.40.25628  0.411
1998 Labbé E, Silvestri C, Hoodless PA, Wrana JL, Attisano L. Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Molecular Cell. 2: 109-20. PMID 9702197 DOI: 10.1016/S1097-2765(00)80119-7  0.637
1998 Attisano L, Wrana JL. Mads and Smads in TGF beta signalling. Current Opinion in Cell Biology. 10: 188-94. PMID 9561843 DOI: 10.1016/S0955-0674(98)80141-5  0.668
1998 Wrana JL. TGF-beta receptors and signalling mechanisms. Mineral and Electrolyte Metabolism. 24: 120-30. PMID 9525694 DOI: 10.1159/000057359  0.411
1998 Hoodless PA, Wrana JL. Mechanism and function of signaling by the TGF beta superfamily. Current Topics in Microbiology and Immunology. 228: 235-72. PMID 9401209 DOI: 10.1007/978-3-642-80481-6_10  0.311
1997 Piscione TD, Yager TD, Gupta IR, Grinfeld B, Pei Y, Attisano L, Wrana JL, Rosenblum ND. BMP-2 and OP-1 exert direct and opposite effects on renal branching morphogenesis. American Journal of Physiology. Renal Physiology. 273: F961-F975. PMID 29586124 DOI: 10.1152/ajprenal.1997.273.6.F961  0.566
1997 Li M, Li J, Hoodless PA, Tzukazaki T, Wrana JL, Attisano L, Tsang BK. Mothers Against Decapentaplegic-Related Protein 2 Expression in Avian Granulosa Cells Is Up-Regulated by Transforming Growth Factor β during Ovarian Follicular Development. Endocrinology. 138: 3659-3665. PMID 28200210 DOI: 10.1210/Endo.138.9.5376  0.64
1997 Abdollah S, Macías-Silva M, Tsukazaki T, Hayashi H, Attisano L, Wrana JL. TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling. The Journal of Biological Chemistry. 272: 27678-85. PMID 9346908 DOI: 10.1074/Jbc.272.44.27678  0.668
1997 Wrana JL, Attisano L. MAD-related proteins in TGF-beta signalling. Trends in Genetics : Tig. 12: 493-6. PMID 9257525 DOI: 10.1016/S0168-9525(96)30109-1  0.642
1997 Hayashi H, Abdollah S, Qiu Y, Cai J, Xu YY, Grinnell BW, Richardson MA, Topper JN, Gimbrone MA, Wrana JL, Falb D. The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell. 89: 1165-73. PMID 9215638 DOI: 10.1016/S0092-8674(00)80303-7  0.367
1997 Attisano L, Wrana JL. Signal transduction by members of the transforming growth factor-beta superfamily. Cytokine & Growth Factor Reviews. 7: 327-39. PMID 9023056 DOI: 10.1016/S1359-6101(96)00042-1  0.675
1997 Macías-Silva M, Abdollah S, Hoodless PA, Pirone R, Attisano L, Wrana JL. MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell. 87: 1215-24. PMID 8980228 DOI: 10.1016/S0092-8674(00)81817-6  0.63
1996 Holley SA, Neul JL, Attisano L, Wrana JL, Sasai Y, O'Connor MB, De Robertis EM, Ferguson EL. The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor. Cell. 86: 607-17. PMID 8752215 DOI: 10.1016/S0092-8674(00)80134-8  0.613
1996 Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui LC, Bapat B, Gallinger S, Andrulis IL, Thomsen GH, Wrana JL, Attisano L. MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell. 86: 543-52. PMID 8752209 DOI: 10.1016/S0092-8674(00)80128-2  0.601
1996 Hoodless PA, Haerry T, Abdollah S, Stapleton M, O'Connor MB, Attisano L, Wrana JL. MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell. 85: 489-500. PMID 8653785 DOI: 10.1016/S0092-8674(00)81250-7  0.671
1996 Attisano L, Wrana JL, Montalvo E, Massagué J. Activation of signalling by the activin receptor complex. Molecular and Cellular Biology. 16: 1066-73. PMID 8622651 DOI: 10.1128/Mcb.16.3.1066  0.705
1995 Manova K, De Leon V, Angeles M, Kalantry S, Giarré M, Attisano L, Wrana J, Bachvarova RF. mRNAs for activin receptors II and IIB are expressed in mouse oocytes and in the epiblast of pregastrula and gastrula stage mouse embryos. Mechanisms of Development. 49: 3-11. PMID 7748787 DOI: 10.1016/0925-4773(94)00295-X  0.565
1995 Vivien D, Attisano L, Wrana JL, Massagué J. Signaling activity of homologous and heterologous transforming growth factor-beta receptor kinase complexes. The Journal of Biological Chemistry. 270: 7134-41. PMID 7706250 DOI: 10.1074/Jbc.270.13.7134  0.681
1995 Letsou A, Arora K, Wrana JL, Simin K, Twombly V, Jamal J, Staehling-Hampton K, Hoffmann FM, Gelbart WM, Massagué J. Drosophila Dpp signaling is mediated by the punt gene product: a dual ligand-binding type II receptor of the TGF beta receptor family. Cell. 80: 899-908. PMID 7697720 DOI: 10.1016/0092-8674(95)90293-7  0.566
1995 Vivien D, Wrana JL. Ligand-induced recruitment and phosphorylation of reduced TGF-beta type I receptor. Experimental Cell Research. 221: 60-5. PMID 7589256 DOI: 10.1006/excr.1995.1352  0.5
1995 Wieser R, Wrana J, Massagué J. GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex. The Embo Journal. 14: 2199-2208. DOI: 10.1002/J.1460-2075.1995.Tb07214.X  0.537
1994 Shapiro HS, Chen J, Wrana JL, Zhang Q, Blum M, Sodek J. Characterization of porcine bone sialoprotein: primary structure and cellular expression. Matrix (Stuttgart, Germany). 13: 431-40. PMID 8309422 DOI: 10.1016/S0934-8832(11)80109-5  0.488
1994 Wrana JL, Tran H, Attisano L, Arora K, Childs SR, Massagué J, O'Connor MB. Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex Molecular and Cellular Biology. 14: 944-950. PMID 8289834 DOI: 10.1128/Mcb.14.2.944  0.719
1994 Cárcamo J, Weis FM, Ventura F, Wieser R, Wrana JL, Attisano L, Massagué J. Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin. Molecular and Cellular Biology. 14: 3810-21. PMID 8196624 DOI: 10.1128/Mcb.14.6.3810  0.725
1994 Attisano L, Wrana JL, López-Casillas F, Massagué J. TGF-beta receptors and actions. Biochimica Et Biophysica Acta. 1222: 71-80. PMID 8186268 DOI: 10.1016/0167-4889(94)90026-4  0.697
1994 Kim RH, Shapiro HS, Li JJ, Wrana JL, Sodek J. Characterization of the Human Bone SialoProtein (BSP) Gene and its Promoter Sequence Matrix Biology. 14: 31-40. PMID 8061918 DOI: 10.1016/0945-053X(94)90027-2  0.509
1994 Wrana JL, Attisano L, Wieser R, Ventura F, Massagué J. Mechanism of activation of the TGF-beta receptor. Nature. 370: 341-7. PMID 8047140 DOI: 10.1038/370341A0  0.734
1994 Brummel TJ, Twombly V, Marqués G, Wrana JL, Newfeld SJ, Attisano L, Massagué J, O'Connor MB, Gelbart WM. Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila. Cell. 78: 251-61. PMID 8044839 DOI: 10.1016/0092-8674(94)90295-X  0.706
1994 Penton A, Chen Y, Staehling-Hampton K, Wrana JL, Attisano L, Szidonya J, Cassill JA, Massagué J, Hoffmann FM. Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor. Cell. 78: 239-50. PMID 8044838 DOI: 10.1016/0092-8674(94)90294-1  0.712
1994 Ventura F, Doody J, Liu F, Wrana J, Massagué J. Reconstitution and transphosphorylation of TGF-beta receptor complexes. The Embo Journal. 13: 5581-5589. DOI: 10.1002/J.1460-2075.1994.Tb06895.X  0.497
1993 Childs SR, Wrana JL, Arora K, Attisano L, O'Connor MB, Massagué J. Identification of a Drosophila activin receptor Proceedings of the National Academy of Sciences of the United States of America. 90: 9475-9479. PMID 8415726 DOI: 10.1073/Pnas.90.20.9475  0.716
1993 López-Casillas F, Wrana JL, Massagué J. Betaglycan presents ligand to the TGF beta signaling receptor. Cell. 73: 1435-44. PMID 8391934 DOI: 10.1016/0092-8674(93)90368-Z  0.573
1993 Wieser R, Attisano L, Wrana JL, Massagué J. Signaling activity of transforming growth factor beta type II receptors lacking specific domains in the cytoplasmic region. Molecular and Cellular Biology. 13: 7239-47. PMID 8246946 DOI: 10.1128/Mcb.13.12.7239  0.721
1993 Attisano L, Cárcamo J, Ventura F, Weis FM, Massagué J, Wrana JL. Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors. Cell. 75: 671-80. PMID 8242742 DOI: 10.1016/0092-8674(93)90488-C  0.723
1993 Wrana JL, Cárcamo J, Attisano L, Cheifetz S, Zentella A, López-Casillas F, Massagué J. The type II TGF-beta receptor signals diverse responses in cooperation with the type I receptor. Cold Spring Harbor Symposia On Quantitative Biology. 57: 81-6. PMID 1339707 DOI: 10.1101/Sqb.1992.057.01.011  0.711
1993 Wrana JL, Attisano L, Cárcamo J, Zentella A, Doody J, Laiho M, Wang XF, Massagué J. TGF beta signals through a heteromeric protein kinase receptor complex. Cell. 71: 1003-14. PMID 1333888 DOI: 10.1016/0092-8674(92)90395-S  0.726
1993 López-Casillas F, Wrana J, Massagué J. Receptor of the third kind Trends in Cell Biology. 3: 334. DOI: 10.1016/0962-8924(93)90100-F  0.439
1992 Zhang Q, Wrana JL, Sodek J. Characterization of the promoter region of the porcine opn (osteopontin, secreted phosphoprotein 1) gene. Identification of positive and negative regulatory elements and a 'silent' second promoter. European Journal of Biochemistry. 207: 649-59. PMID 1633816 DOI: 10.1111/J.1432-1033.1992.Tb17092.X  0.514
1992 Massagué J, Andres J, Attisano L, Cheifetz S, López-Casillas F, Ohtsuki M, Wrana JL. TGF-beta receptors. Molecular Reproduction and Development. 32: 99-104. PMID 1322148 DOI: 10.1002/Mrd.1080320204  0.736
1992 Attisano L, Wrana JL, Cheifetz S, Massagué J. Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors. Cell. 68: 97-108. PMID 1310075 DOI: 10.1016/0092-8674(92)90209-U  0.678
1991 Chen JK, Shapiro HS, Wrana JL, Reimers S, Heersche JN, Sodek J. Localization of bone sialoprotein (BSP) expression to sites of mineralized tissue formation in fetal rat tissues by in situ hybridization. Matrix (Stuttgart, Germany). 11: 133-43. PMID 2072878 DOI: 10.1016/S0934-8832(11)80217-9  0.487
1991 Wrana JL, Kubota T, Zhang Q, Overall CM, Aubin JE, Butler WT, Sodek J. Regulation of transformation-sensitive secreted phosphoprotein (SPPI/osteopontin) expression by transforming growth factor-beta. Comparisons with expression of SPARC (secreted acidic cysteine-rich protein). The Biochemical Journal. 273: 523-31. PMID 1996953 DOI: 10.1042/Bj2730523  0.689
1991 Kasugai S, Zhang Q, Overall CM, Wrana JL, Butler WT, Sodek J. Differential regulation of the 55 and 44 kDa forms of secreted phosphoprotein 1 (SPP-1, osteopontin) in normal and transformed rat bone cells by osteotropic hormones, growth factors and a tumor promoter. Bone and Mineral. 13: 235-50. PMID 1863811 DOI: 10.1016/0169-6009(91)90071-7  0.667
1991 Overall CM, Wrana JL, Sodek J. Induction of formative and resorptive cellular phenotypes in human gingival fibroblasts by TGF-beta 1 and concanavalin A: regulation of matrix metalloproteinases and TIMP. Journal of Periodontal Research. 26: 279-82. PMID 1831853 DOI: 10.1111/J.1600-0765.1991.Tb01658.X  0.67
1991 Wrana JL, Overall CM, Sodek J. Regulation of the expression of a secreted acidic protein rich in cysteine (SPARC) in human fibroblasts by transforming growth factor beta. Comparison of transcriptional and post-transcriptional control with fibronectin and type I collagen. European Journal of Biochemistry. 197: 519-28. PMID 1709099 DOI: 10.1111/J.1432-1033.1991.Tb15940.X  0.685
1990 Wrana JL, Zhang Q, Sodek J. Full length cDNA sequence of porcine secreted phosphoprotein-I (SPP-I, osteopontin). Nucleic Acids Research. 17: 10119. PMID 2602123 DOI: 10.1093/Nar/17.23.10119  0.431
1989 Kubota T, Zhang Q, Wrana JL, Ber R, Aubin JE, Butler WT, Sodek J. Multiple forms of SppI (secreted phosphoprotein, osteopontin) synthesized by normal and transformed rat bone cell populations: regulation by TGF-beta. Biochemical and Biophysical Research Communications. 162: 1453-9. PMID 2764941 DOI: 10.1016/0006-291X(89)90837-1  0.53
1989 Overall CM, Wrana JL, Sodek J. Transforming growth factor-beta regulation of collagenase, 72 kDa-progelatinase, TIMP and PAI-1 expression in rat bone cell populations and human fibroblasts. Connective Tissue Research. 20: 289-94. PMID 2558843 DOI: 10.3109/03008208909023899  0.687
1988 Wrana JL, Maeno M, Hawrylyshyn B, Yao KL, Domenicucci C, Sodek J. Differential effects of transforming growth factor-beta on the synthesis of extracellular matrix proteins by normal fetal rat calvarial bone cell populations. The Journal of Cell Biology. 106: 915-24. PMID 3162238 DOI: 10.1083/Jcb.106.3.915  0.574
1986 Wrana JL, Sodek J, Ber RL, Bellows CG. The effects of platelet-derived transforming growth factor beta on normal human diploid gingival fibroblasts. European Journal of Biochemistry. 159: 69-76. PMID 3488905 DOI: 10.1111/J.1432-1033.1986.Tb09834.X  0.587
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