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Nicholas Denko - Publications

Affiliations: 
Stanford University, Palo Alto, CA 
Area:
Molecular Biology, Cell Biology
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29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Wolfe AR, Cui T, Baie S, Corrales-Guerrero S, Webb A, Castro-Aceituno V, Shyu DL, Karasinska JM, Topham JT, Renouf DJ, Schaeffer DF, Halloran M, Packard R, Robb R, Chen W, ... Denko N, et al. Nutrient scavenging-fueled growth in pancreatic cancer depends on caveolae-mediated endocytosis under nutrient-deprived conditions. Science Advances. 10: eadj3551. PMID 38427741 DOI: 10.1126/sciadv.adj3551  0.317
2021 Benej M, Wu J, Kreamer M, Kery M, Corrales-Guerrero S, Papandreou I, Williams TM, Li Z, Graves EE, Selmic LE, Denko NC. Pharmacological Regulation of Tumor Hypoxia in Model Murine Tumors and Spontaneous Canine Tumors. Cancers. 13. PMID 33916656 DOI: 10.3390/cancers13071696  0.304
2018 Benej M, Hong X, Vibhute S, Scott S, Wu J, Graves E, Le QT, Koong AC, Giaccia AJ, Yu B, Chen SC, Papandreou I, Denko NC. Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism. Proceedings of the National Academy of Sciences of the United States of America. PMID 30201710 DOI: 10.1073/Pnas.1808945115  0.371
2017 O'Neill W, Golias T, Benej M, Denko N. Abstract 5467: Phosphoproteomic analysis of pyruvate dehydrogenase in response to environmental stress Cancer Research. 77: 5467-5467. DOI: 10.1158/1538-7445.Am2017-5467  0.302
2015 Cerniglia GJ, Dey S, Gallagher-Colombo SM, Daurio NA, Tuttle S, Busch TM, Lin A, Sun R, Esipova TV, Vinogradov SA, Denko N, Koumenis C, Maity A. The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation. Molecular Cancer Therapeutics. 14: 1928-38. PMID 25995437 DOI: 10.1158/1535-7163.Mct-14-0888  0.334
2014 Denko NC. Hypoxic regulation of metabolism offers new opportunities for anticancer therapy. Expert Review of Anticancer Therapy. 14: 979-81. PMID 24930453 DOI: 10.1586/14737140.2014.930345  0.344
2014 Sun RC, Denko NC. Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth. Cell Metabolism. 19: 285-92. PMID 24506869 DOI: 10.1016/j.cmet.2013.11.022  0.325
2012 Jaitin D, Sayles L, Goliazova T, Denko N, Sweet-Cordero A. Abstract 1000: Oncogenic Kras inhibits mitochondrial metabolism by regulating the pyruvate dehydrogenase complex under conditions of nutrient stress Cancer Research. 72: 1000-1000. DOI: 10.1158/1538-7445.Am2012-1000  0.421
2010 Spiotto MT, Banh A, Papandreou I, Cao H, Galvez MG, Gurtner GC, Denko NC, Le QT, Koong AC. Imaging the unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict tumor growth. Cancer Research. 70: 78-88. PMID 20028872 DOI: 10.1158/0008-5472.Can-09-2747  0.32
2009 Chen Y, Cairns R, Papandreou I, Koong A, Denko NC. Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect. Plos One. 4: e7033. PMID 19753307 DOI: 10.1371/Journal.Pone.0007033  0.333
2008 Verras M, Papandreou I, Lim AL, Denko NC. Tumor hypoxia blocks Wnt processing and secretion through the induction of endoplasmic reticulum stress. Molecular and Cellular Biology. 28: 7212-24. PMID 18824543 DOI: 10.1128/Mcb.00947-08  0.594
2008 Papandreou I, Lim AL, Laderoute K, Denko NC. Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L. Cell Death and Differentiation. 15: 1572-81. PMID 18551130 DOI: 10.1038/Cdd.2008.84  0.638
2008 Johnson AB, Denko N, Barton MC. Hypoxia induces a novel signature of chromatin modifications and global repression of transcription. Mutation Research. 640: 174-9. PMID 18294659 DOI: 10.1016/J.Mrfmmm.2008.01.001  0.439
2007 Cairns RA, Papandreou I, Sutphin PD, Denko NC. Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy. Proceedings of the National Academy of Sciences of the United States of America. 104: 9445-50. PMID 17517659 DOI: 10.1073/Pnas.0611662104  0.389
2006 Ameri K, Hammond EM, Culmsee C, Raida M, Katschinski DM, Wenger RH, Wagner E, Davis RJ, Hai T, Denko N, Harris AL. Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway. Oncogene. 26: 284-9. PMID 16847457 DOI: 10.1038/Sj.Onc.1209781  0.455
2006 Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metabolism. 3: 187-97. PMID 16517406 DOI: 10.1016/J.Cmet.2006.01.012  0.612
2006 Cairns R, Papandreou I, Denko N. Overcoming physiologic barriers to cancer treatment by molecularly targeting the tumor microenvironment. Molecular Cancer Research : McR. 4: 61-70. PMID 16513837 DOI: 10.1158/1541-7786.Mcr-06-0002  0.422
2005 Papandreou I, Krishna C, Kaper F, Cai D, Giaccia AJ, Denko NC. Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment. Cancer Research. 65: 3171-8. PMID 15833847 DOI: 10.1158/0008-5472.Can-04-3395  0.467
2005 Papandreou I, Powell A, Lim AL, Denko N. Cellular reaction to hypoxia: sensing and responding to an adverse environment. Mutation Research. 569: 87-100. PMID 15603754 DOI: 10.1016/J.Mrfmmm.2004.06.054  0.612
2004 Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee AH, Yoshida H, Mori K, Glimcher LH, Denko NC, Giaccia AJ, Le QT, Koong AC. XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Research. 64: 5943-7. PMID 15342372 DOI: 10.1158/0008-5472.Can-04-1606  0.388
2004 Leo C, Giaccia AJ, Denko NC. The hypoxic tumor microenvironment and gene expression. Seminars in Radiation Oncology. 14: 207-14. PMID 15254863 DOI: 10.1016/J.Semradonc.2004.04.007  0.345
2004 Le QT, Denko NC, Giaccia AJ. Hypoxic gene expression and metastasis Cancer and Metastasis Reviews. 23: 293-310. PMID 15197330 DOI: 10.1023/B:Canc.0000031768.89246.D7  0.42
2003 Denko NC, Fontana LA, Hudson KM, Sutphin PD, Raychaudhuri S, Altman R, Giaccia AJ. Investigating hypoxic tumor physiology through gene expression patterns. Oncogene. 22: 5907-14. PMID 12947397 DOI: 10.1038/Sj.Onc.1206703  0.367
2003 Denko N, Wernke-Dollries K, Johnson AB, Hammond E, Chiang CM, Barton MC. Hypoxia actively represses transcription by inducing negative cofactor 2 (Dr1/DrAP1) and blocking preinitiation complex assembly. The Journal of Biological Chemistry. 278: 5744-9. PMID 12477712 DOI: 10.1074/Jbc.M212534200  0.414
2001 Le Q, Sutphin P, Raychaudhuri S, Terris D, Lin H, Koong A, Chen U, Tibshirani R, Denko N, Giaccia A. Osteopontin - a new serum marker for tumor hypoxia International Journal of Radiation Oncology*Biology*Physics. 51: 80. DOI: 10.1016/S0360-3016(01)01971-X  0.326
1998 Giaccia AJ, Brown JM, Wouters B, Denko N, Koumenis C. Cancer therapy and tumor physiology. Science (New York, N.Y.). 279: 12-3. PMID 9441397 DOI: 10.1126/Science.279.5347.10E  0.374
1997 Denko N, Langland R, Barton M, Lieberman MA. Uncoupling of S-phase and mitosis by recombinant cytotoxic necrotizing factor 2 (CNF2). Experimental Cell Research. 234: 132-8. PMID 9223378 DOI: 10.1006/Excr.1997.3595  0.365
1996 Hudson K, Denko N, Schwab E, Oswald E, Weiss A, Lieberman M. Megakaryocytic cell line-specific hyperploidy by cytotoxic necrotizing factor bacterial toxins Blood. 88: 3465-3473. DOI: 10.1182/Blood.V88.9.3465.Bloodjournal8893465  0.33
1993 Shaw-white JR, Denko N, Albers L, Doetschman TC, Stringer JR. Expression of the lacZ gene targeted to the HPRT locus in embryonic stem cells and their derivatives Transgenic Research. 2: 1-13. PMID 8513334 DOI: 10.1007/Bf01977675  0.328
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