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Gregg L. Semenza - Publications

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
Cell Biology, Molecular Biology
Website:
https://www.hopkinsmedicine.org/profiles/results/directory/profile/0800056/gregg-semenza
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482 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Lyu Y, Yang Y, Talwar V, Lu H, Chen C, Salman S, Wicks EE, Huang TY, Drehmer D, Wang Y, Zuo Q, Datan E, Jackson W, Dordai D, Wang R, ... Semenza GL, et al. Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes. Cell Reports. 43: 113972. PMID 38517892 DOI: 10.1016/j.celrep.2024.113972  0.814
2023 Gilkes DM, Bajpai S, Wong CC, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL. Retraction: Procollagen Lysyl Hydroxylase 2 Is Essential for Hypoxia-Induced Breast Cancer Metastasis. Molecular Cancer Research : McR. 21: 1120. PMID 37779464 DOI: 10.1158/1541-7786.MCR-23-0654  0.829
2023 Semenza GL. Mechanisms of Breast Cancer Stem Cell Specification and Self-Renewal Mediated by Hypoxia-Inducible Factor 1. Stem Cells Translational Medicine. PMID 37768037 DOI: 10.1093/stcltm/szad061  0.453
2023 Semenza GL. Targeting intratumoral hypoxia to enhance anti-tumor immunity. Seminars in Cancer Biology. 96: 5-10. PMID 37717718 DOI: 10.1016/j.semcancer.2023.09.002  0.341
2023 Gilkes DM, Bajpai S, Chaturvedi P, Wirtz D, Semenza GL. Withdrawal: Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts. The Journal of Biological Chemistry. 299: 105144. PMID 37586148 DOI: 10.1016/j.jbc.2023.105144  0.82
2023 Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ, Semenza GL. Withdrawal: Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. The Journal of Biological Chemistry. 299: 105125. PMID 37556879 DOI: 10.1016/j.jbc.2023.105125  0.66
2023 Zuo Q, Yang Y, Lyu Y, Yang C, Chen C, Salman S, Huang TY, Wicks EE, Jackson W, Datan E, Qin W, Semenza GL. Plexin-B3 expression stimulates MET signaling, breast cancer stem cell specification, and lung metastasis. Cell Reports. 42: 112164. PMID 36857181 DOI: 10.1016/j.celrep.2023.112164  0.843
2022 Yang Y, Chen C, Zuo Q, Lu H, Salman S, Lyu Y, Huang TY, Wicks EE, Jackson W, Datan E, Wang R, Wang Y, Le N, Zhu Y, Qin W, ... Semenza GL, et al. NARF is a hypoxia-induced coactivator for OCT4-mediated breast cancer stem cell specification. Science Advances. 8: eabo5000. PMID 36490339 DOI: 10.1126/sciadv.abo5000  0.853
2022 Poll SR, Martin R, Wohler E, Partan ES, Walek E, Salman S, Groepper D, Kratz L, Cernach M, Jesus-Garcia R, Haldeman-Englert C, Choi YJ, Morris CD, Cohen B, Hoover-Fong J, ... ... Semenza GL, et al. Disruption of the HIF-1 pathway in individuals with Ollier disease and Maffucci syndrome. Plos Genetics. 18: e1010504. PMID 36480544 DOI: 10.1371/journal.pgen.1010504  0.282
2022 Koyasu S, Horita S, Saito K, Kobayashi M, Ishikita H, Chow CC, Kambe G, Nishikawa S, Menju T, Morinibu A, Okochi Y, Tabuchi Y, Onodera Y, Takeda N, Date H, ... Semenza GL, et al. ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to promote cancer aggressiveness. Embo Reports. e202154042. PMID 36341521 DOI: 10.15252/embr.202154042  0.71
2022 Semenza GL. Regulation of Erythropoiesis by the Hypoxia-Inducible Factor Pathway: Effects of Genetic and Pharmacological Perturbations. Annual Review of Medicine. PMID 35773226 DOI: 10.1146/annurev-med-042921-102602  0.42
2022 Semenza GL. Hypoxia-inducible factors: roles in cardiovascular disease progression, prevention, and treatment. Cardiovascular Research. PMID 35687650 DOI: 10.1093/cvr/cvac089  0.366
2022 Qin Y, Dinabandhu A, Cao X, Sanchez JC, Jee K, Rodrigues M, Guo C, Zhang J, Vancel J, Menon D, Khan NS, Ma T, Tzeng SY, Daoud YJ, Green JJ, ... Semenza GL, et al. ANGPTL4 influences the therapeutic response of neovascular age-related macular degeneration patients by promoting choroidal neovascularization. Jci Insight. PMID 35653189 DOI: 10.1172/jci.insight.157896  0.332
2022 Wicks EE, Semenza GL. Hypoxia-inducible factors: cancer progression and clinical translation. The Journal of Clinical Investigation. 132. PMID 35642641 DOI: 10.1172/JCI159839  0.508
2022 Salman S, Meyers DJ, Wicks EE, Lee SN, Datan E, Thomas AM, Anders NM, Hwang Y, Lyu Y, Yang Y, Jackson W, Dordai D, Rudek MA, Semenza GL. HIF inhibitor 32-134D eradicates murine hepatocellular carcinoma in combination with anti-PD1 therapy. The Journal of Clinical Investigation. 132. PMID 35499076 DOI: 10.1172/JCI156774  0.792
2022 Jiang X, Tian W, Kim D, McQuiston AS, Vinh R, Rockson SG, Semenza GL, Nicolls MR. Hypoxia and Hypoxia-Inducible Factors in Lymphedema. Frontiers in Pharmacology. 13: 851057. PMID 35450048 DOI: 10.3389/fphar.2022.851057  0.316
2022 Samanta D, Park Y, Andrabi SA, Shelton LM, Gilkes DM, Semenza GL. Correction: PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis. Cancer Research. 82: 1153. PMID 35288733 DOI: 10.1158/0008-5472.CAN-21-4328  0.813
2022 Gilkes DM, Chaturvedi P, Bajpai S, Wong CC, Wei H, Pitcairn S, Hubbi ME, Wirtz D, Semenza GL. Editor's Note: Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis. Cancer Research. 82: 943. PMID 35247897 DOI: 10.1158/0008-5472.CAN-21-4312  0.813
2022 Yang Y, Lu H, Chen C, Lyu Y, Cole RN, Semenza GL. HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia. Nature Communications. 13: 316. PMID 35031618 DOI: 10.1038/s41467-021-27944-8  0.429
2021 Casadevall A, Jackson S, Semenza GL, Tomaselli GF, Ahima RS. The Journal of Clinical Investigation in the time of COVID-19. The Journal of Clinical Investigation. 131. PMID 34907915 DOI: 10.1172/JCI156409  0.213
2021 Liu X, Xie P, Hao N, Zhang M, Liu Y, Liu P, Semenza GL, He J, Zhang H. HIF-1-regulated expression of calreticulin promotes breast tumorigenesis and progression through Wnt/β-catenin pathway activation. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34706936 DOI: 10.1073/pnas.2109144118  0.494
2021 Semenza GL. Heritable disorders of oxygen sensing. American Journal of Medical Genetics. Part A. 185: 3334-3339. PMID 34655169 DOI: 10.1002/ajmg.a.62521  0.395
2021 Lu H, Lyu Y, Tran L, Lan J, Xie Y, Yang Y, Murugan NL, Wang YJ, Semenza GL. HIF-1 recruits NANOG as a coactivator for TERT gene transcription in hypoxic breast cancer stem cells. Cell Reports. 36: 109757. PMID 34592152 DOI: 10.1016/j.celrep.2021.109757  0.485
2021 Wang Y, Lyu Y, Tu K, Xu Q, Yang Y, Salman S, Le N, Lu H, Chen C, Zhu Y, Wang R, Liu Q, Semenza GL. Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization. Science Advances. 7. PMID 34452909 DOI: 10.1126/sciadv.abe3771  0.525
2021 Semenza GL. Breakthrough Science: Hypoxia-Inducible Factors, Oxygen Sensing, and Disorders of Hematopoiesis. Blood. PMID 34411243 DOI: 10.1182/blood.2021011043  0.411
2021 Zhang J, Qin Y, Martinez M, Flores-Bellver M, Rodrigues M, Dinabandhu A, Cao X, Deshpande M, Qin Y, Aparicio-Domingo S, Rui Y, Tzeng SY, Salman S, Yuan J, Scott AW, ... ... Semenza GL, et al. HIF-1α and HIF-2α redundantly promote retinal neovascularization in patients with ischemic retinal disease. The Journal of Clinical Investigation. 131. PMID 34128478 DOI: 10.1172/JCI139202  0.407
2021 Semenza GL. Heritable disorders of oxygen sensing. American Journal of Medical Genetics. Part A. PMID 33973706 DOI: 10.1002/ajmg.a.62250  0.395
2021 Wang R, Godet I, Yang Y, Salman S, Lu H, Lyu Y, Zuo Q, Wang Y, Zhu Y, Chen C, He J, Gilkes DM, Semenza GL. Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33952697 DOI: 10.1073/pnas.2020490118  0.845
2021 Hu K, Babapoor-Farrokhran S, Rodrigues M, Deshpande M, Puchner B, Kashiwabuchi F, Hassan SJ, Asnaghi L, Handa JT, Merbs S, Eberhart CG, Semenza GL, Montaner S, Sodhi A. Correction: Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma. Oncotarget. 12: 519-520. PMID 33747364 DOI: 10.18632/oncotarget.27780  0.384
2021 Semenza GL. Intratumoral Hypoxia and Mechanisms of Immune Evasion Mediated by Hypoxia-Inducible Factors. Physiology (Bethesda, Md.). 36: 73-83. PMID 33595388 DOI: 10.1152/physiol.00034.2020  0.443
2021 Lu H, Chen I, Shimoda LA, Park Y, Zhang C, Tran L, Zhang H, Semenza GL. Chemotherapy-Induced Ca Release Stimulates Breast Cancer Stem Cell Enrichment. Cell Reports. 34: 108605. PMID 33406433 DOI: 10.1016/j.celrep.2020.108605  0.376
2021 Liu Z, Sun L, Cai Y, Shen S, Zhang T, Wang N, Wu G, Ma W, Li ST, Suo C, Hao Y, Jia WD, Semenza GL, Gao P, Zhang H. Hypoxia-induced suppression of alternative splicing of MBD2 promotes breast cancer metastasis via activation of FZD1. Cancer Research. PMID 33402389 DOI: 10.1158/0008-5472.CAN-20-2876  0.488
2020 Wang N, Shi XF, Khan SA, Wang B, Semenza GL, Prabhakar NR, Nanduri J. Hypoxia inducible factor-1 mediates pancreatic β-cell dysfunction by intermittent hypoxia. American Journal of Physiology. Cell Physiology. PMID 32936698 DOI: 10.1152/Ajpcell.00309.2020  0.481
2020 Samanta D, Huang TY, Shah R, Yang Y, Pan F, Semenza GL. BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy Efficacy. Cell Reports. 32: 108073. PMID 32846130 DOI: 10.1016/J.Celrep.2020.108073  0.492
2020 Jiang X, Tian W, Granucci EJ, Tu AB, Kim D, Dahms P, Pasupneti S, Peng G, Kim Y, Lim AH, Espinoza FH, Cribb M, Dixon JB, Rockson SG, Semenza GL, et al. Decreased lymphatic HIF-2α accentuates lymphatic remodeling in lymphedema. The Journal of Clinical Investigation. PMID 32673288 DOI: 10.1172/Jci136164  0.507
2020 Pasupneti S, Tian W, Tu AB, Dahms P, Granucci E, Gandjeva A, Xiang M, Butcher E, Semenza GL, Tuder R, Jiang X, Nicolls MR. Endothelial HIF-2α as a Key Endogenous Mediator Preventing Emphysema. American Journal of Respiratory and Critical Care Medicine. PMID 32515984 DOI: 10.1164/Rccm.202001-0078Oc  0.482
2020 Lu H, Xie Y, Tran L, Lan J, Yang Y, Murugan NL, Wang R, Wang YJ, Semenza GL. Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness. The Journal of Clinical Investigation. PMID 32427586 DOI: 10.1172/Jci138577  0.577
2020 Semenza GL. The Genomics and Genetics of Oxygen Homeostasis. Annual Review of Genomics and Human Genetics. PMID 32255719 DOI: 10.1146/Annurev-Genom-111119-073356  0.498
2020 Ahima RS, Jackson S, Casadevall A, Semenza GL, Tomaselli G, Collins KL, Lieberman AP, Martin DM, Reddy P. Changing the editorial process at JCI and JCI Insight in response to the COVID-19 pandemic. The Journal of Clinical Investigation. PMID 32202513 DOI: 10.1172/Jci138305  0.302
2019 Bohuslavova R, Cerychova R, Papousek F, Olejnickova V, Bartos M, Görlach A, Kolar F, Sedmera D, Semenza GL, Pavlinkova G. HIF-1α is required for development of the sympathetic nervous system. Proceedings of the National Academy of Sciences of the United States of America. PMID 31196952 DOI: 10.1073/Pnas.1903510116  0.449
2019 Dabral S, Muecke C, Valasarajan C, Schmoranzer M, Wietelmann A, Semenza GL, Meister M, Muley T, Seeger-Nukpezah T, Samakovlis C, Weissmann N, Grimminger F, Seeger W, Savai R, Pullamsetti SS. A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension. Nature Communications. 10: 2130. PMID 31086178 DOI: 10.1038/S41467-019-10044-Z  0.538
2019 Casadevall A, Semenza GL, Jackson S, Tomaselli G, Ahima RS. Reducing bias: accounting for the order of co-first authors. The Journal of Clinical Investigation. 130. PMID 31033485 DOI: 10.1172/Jci128764  0.328
2019 Xiang L, Semenza GL. Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy. Advances in Cancer Research. 141: 175-212. PMID 30691683 DOI: 10.1016/Bs.Acr.2018.11.001  0.586
2019 Xiang L, Mou J, Shao B, Wei Y, Liang H, Takano N, Semenza GL, Xie G. Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization. Cell Death & Disease. 10: 40. PMID 30674873 DOI: 10.1038/S41419-018-1291-5  0.544
2019 Semenza GL. Pharmacologic Targeting of Hypoxia-Inducible Factors. Annual Review of Pharmacology and Toxicology. 59: 379-403. PMID 30625281 DOI: 10.1146/Annurev-Pharmtox-010818-021637  0.515
2019 Sadek HA, Semenza GL. Editorial overview: Hypoxia Current Opinion in Physiology. 7: iii-v. DOI: 10.1016/J.Cophys.2019.02.002  0.46
2018 Jiang X, Tian W, Tu AB, Pasupneti S, Shuffle E, Dahms P, Zhang P, Cai H, Dinh TT, Liu B, Cain C, Giaccia AJ, Butcher EC, Simon C, Semenza GL, et al. Endothelial HIF-2α is Required for the Maintenance of Airway Microvasculature. Circulation. PMID 30586708 DOI: 10.1161/Circulationaha.118.036157  0.48
2018 Lan J, Lu H, Samanta D, Salman S, Lu Y, Semenza GL. Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment. Proceedings of the National Academy of Sciences of the United States of America. PMID 30242135 DOI: 10.1073/Pnas.1809695115  0.602
2018 Samanta D, Semenza GL. Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors. Biochimica Et Biophysica Acta. PMID 30006019 DOI: 10.1016/J.Bbcan.2018.07.002  0.511
2018 Lu H, Tran L, Park Y, Chen I, Lan J, Xie Y, Semenza GL. Reciprocally Regulation of DUSP9 and DUSP16 Expression by HIF-1 Controls ERK and p38 MAP Kinase Activity and Mediates Chemotherapy-Induced Breast Cancer Stem Cell Enrichment. Cancer Research. PMID 29880481 DOI: 10.1158/0008-5472.Can-18-0270  0.563
2018 Bao L, Chen Y, Lai HT, Wu SY, Wang JE, Hatanpaa KJ, Raisanen JM, Fontenot M, Lega B, Chiang CM, Semenza GL, Wang Y, Luo W. Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration. Nucleic Acids Research. PMID 29860315 DOI: 10.1093/Nar/Gky449  0.745
2018 Li J, Yang Q, Bai Z, Semenza GL, Ge RL. Chronic cold exposure results in subcutaneous adipose tissue browning and altered global metabolism in Qinghai-Tibetan plateau pika (Ochotona curzoniae). Biochemical and Biophysical Research Communications. PMID 29626477 DOI: 10.1016/J.Bbrc.2018.03.147  0.399
2018 Samanta D, Park Y, Ni X, Li H, Zahnow CA, Gabrielson E, Pan F, Semenza GL. Chemotherapy induces enrichment of CD47+/CD73+/PDL1+ immune evasive triple-negative breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 29367423 DOI: 10.1073/Pnas.1718197115  0.492
2018 Semenza GL, Prabhakar NR. The role of hypoxia-inducible factors in carotid body (patho) physiology. The Journal of Physiology. PMID 29359806 DOI: 10.1113/Jp275696  0.509
2018 Samanta D, Semenza GL. In Vitro Assays of Breast Cancer Stem Cells. Methods in Molecular Biology (Clifton, N.J.). 1742: 237-246. PMID 29330805 DOI: 10.1007/978-1-4939-7665-2_21  0.506
2018 Bao L, Chen Y, Lai H, Chiang C, Semenza GL, Wang Y, Luo W. Abstract 5427: Inhibition of hypoxia-inducible factor 1 (HIF-1) transcriptional activity and cell mobility via G9a/GLP-mediated methylation of HIF-1α Cancer Research. 78: 5427-5427. DOI: 10.1158/1538-7445.Am2018-5427  0.752
2017 Fu C, Tyagi R, Chin AC, Rojas T, Li RJ, Guha P, Bernstein IA, Rao F, Xu R, Cha JY, Xu J, Snowman AM, Semenza GL, Snyder SH. Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation. Circulation Research. PMID 29279301 DOI: 10.1161/Circresaha.117.311983  0.687
2017 Nanduri J, Peng YJ, Wang N, Khan SA, Semenza GL, Prabhakar NR. DNA methylation in the central and efferent limbs of the chemo reflex requires carotid body neural activity. The Journal of Physiology. PMID 29148180 DOI: 10.1113/Jp274833  0.406
2017 Applewhite BP, Babapoor-Farrokhran S, Poon D, Hassan SJ, Wellmann E, Ying HS, Semenza GL, Montaner S, Sodhi A. Lack of Evidence for Vasoactive and Inflammatory Mediators in the Promotion of Macular Edema Associated with Epiretinal Membranes. Scientific Reports. 7: 10608. PMID 28878218 DOI: 10.1038/S41598-017-08997-6  0.388
2017 Meng Q, Qin Y, Deshpande M, Kashiwabuchi F, Rodrigues M, Lu Q, Ren H, Elisseeff JH, Semenza GL, Montaner SV, Sodhi A. Hypoxia-Inducible Factor-Dependent Expression of Angiopoietin-Like 4 by Conjunctival Epithelial Cells Promotes the Angiogenic Phenotype of Pterygia. Investigative Ophthalmology & Visual Science. 58: 4514-4523. PMID 28873177 DOI: 10.1167/Iovs.17-21974  0.524
2017 Nanduri J, Semenza GL, Prabhakar NR. Epigenetic Changes by DNA methylation in Chronic and Intermittent Hypoxia. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00325.2017. PMID 28839104 DOI: 10.1152/Ajplung.00325.2017  0.437
2017 Jee K, Rodrigues M, Kashiwabuchi F, Applewhite BP, Han I, Lutty G, Goldberg MF, Semenza GL, Montaner S, Sodhi A. Expression of the angiogenic mediator, angiopoietin-like 4, in the eyes of patients with proliferative sickle retinopathy. Plos One. 12: e0183320. PMID 28832635 DOI: 10.1371/Journal.Pone.0183320  0.431
2017 Semenza GL. Next-gen cancer research. Journal of Molecular Medicine (Berlin, Germany). 95: 789. PMID 28707082 DOI: 10.1007/S00109-017-1567-8  0.411
2017 Samanta D, Semenza GL. Maintenance of redox homeostasis by hypoxia-inducible factors. Redox Biology. 13: 331-335. PMID 28624704 DOI: 10.1016/J.Redox.2017.05.022  0.438
2017 Pang Y, Yang C, Schovanek J, Wang H, Bullova P, Caisova V, Gupta G, Wolf KI, Semenza GL, Zhuang Z, Pacak K. Anthracyclines suppress pheochromocytoma cell characteristics, including metastasis, through inhibition of the hypoxia signaling pathway. Oncotarget. 8: 22313-22324. PMID 28423608 DOI: 10.18632/Oncotarget.16224  0.541
2017 Semenza GL. A Compendium of Proteins that Interact with HIF-1α. Experimental Cell Research. PMID 28336293 DOI: 10.1016/J.Yexcr.2017.03.041  0.493
2017 Lu H, Chen I, Shimoda LA, Park Y, Zhang C, Tran L, Zhang H, Semenza GL. Chemotherapy-Induced Ca(2+) Release Stimulates Breast Cancer Stem Cell Enrichment. Cell Reports. 18: 1946-1957. PMID 28228260 DOI: 10.1016/J.Celrep.2017.02.001  0.568
2017 Samanta D, Prabhakar NR, Semenza GL. Systems biology of oxygen homeostasis. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. PMID 28221004 DOI: 10.1002/Wsbm.1382  0.432
2017 Ju JA, Godet I, Ye IC, Byun J, Jayatilaka H, Lee SJ, Xiang L, Samanta D, Lee MH, Wu PH, Wirtz D, Semenza GL, Gilkes DM. Hypoxia Selectively Enhances Integrin Receptor Expression to Promote Metastasis. Molecular Cancer Research : McR. PMID 28213554 DOI: 10.1158/1541-7786.Mcr-16-0338  0.841
2017 Peng YJ, Zhang X, Gridina A, Chupikova I, McCormick DL, Thomas RJ, Scammell TE, Kim G, Vasavda C, Nanduri J, Kumar GK, Semenza GL, Snyder SH, Prabhakar NR. Complementary roles of gasotransmitters CO and H2S in sleep apnea. Proceedings of the National Academy of Sciences of the United States of America. PMID 28115703 DOI: 10.1073/Pnas.1620717114  0.334
2017 Semenza G. 2017 SfRBM Discovery Award Lecture Maintenance Of Oxygen And Redox Homeostasis By Hypoxia-Inducible Factor 1 Free Radical Biology and Medicine. 112: 14. DOI: 10.1016/J.Freeradbiomed.2017.10.367  0.553
2016 Schito L, Semenza GL. Hypoxia-Inducible Factors: Master Regulators of Cancer Progression. Trends in Cancer. 2: 758-770. PMID 28741521 DOI: 10.1016/J.Trecan.2016.10.016  0.814
2016 Semenza GL. Hypoxia-inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype. The Embo Journal. PMID 28007895 DOI: 10.15252/Embj.201695204  0.551
2016 Zeng M, Shen J, Liu Y, Lu LY, Ding K, Fortmann SD, Khan M, Wang J, Hackett SF, Semenza GL, Campochiaro PA. The HIF-1 antagonist acriflavine: visualization in retina and suppression of ocular neovascularization. Journal of Molecular Medicine (Berlin, Germany). PMID 28004126 DOI: 10.1007/S00109-016-1498-9  0.397
2016 Rodrigues M, Kashiwabuchi F, Deshpande M, Jee K, Goldberg MF, Lutty G, Semenza GL, Montaner S, Sodhi A. Expression Pattern of HIF-1α and VEGF Supports Circumferential Application of Scatter Laser for Proliferative Sickle Retinopathy. Investigative Ophthalmology & Visual Science. 57: 6739-6746. PMID 27951596 DOI: 10.1167/Iovs.16-19513  0.442
2016 Samanta D, Semenza GL. Serine Synthesis Helps Hypoxic Cancer Stem Cells Regulate Redox. Cancer Research. PMID 27811150 DOI: 10.1158/0008-5472.Can-16-1730  0.533
2016 Semenza GL. Serendipity, Generosity, and Inspiration. Cell. PMID 27634321 DOI: 10.1016/J.Cell.2016.08.045  0.308
2016 Kaelin WG, Ratcliffe PJ, Semenza GL. Pathways for Oxygen Regulation and Homeostasis: The 2016 Albert Lasker Basic Medical Research Award. Jama. PMID 27622845 DOI: 10.1001/Jama.2016.12386  0.652
2016 Zhang C, Zhi WI, Lu H, Samanta D, Chen I, Gabrielson E, Semenza GL. Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells. Oncotarget. PMID 27590511 DOI: 10.18632/Oncotarget.11743  0.592
2016 Elgogary A, Xu Q, Poore B, Alt J, Zimmermann SC, Zhao L, Fu J, Chen B, Xia S, Liu Y, Neisser M, Nguyen C, Lee R, Park JK, Reyes J, ... ... Semenza GL, et al. Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 27559084 DOI: 10.1073/Pnas.1611406113  0.409
2016 Yuan G, Peng YJ, Khan SA, Nanduri J, Singh A, Vasavda C, Semenza GL, Kumar GK, Snyder SH, Prabhakar NR. H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea. Science Signaling. 9: ra80. PMID 27531649 DOI: 10.1126/Scisignal.Aaf3204  0.407
2016 Nanduri J, Peng YJ, Wang N, Khan SA, Semenza GL, Kumar GK, Prabhakar NR. Epigenetic regulation of redox state mediates persistent cardiorespiratory abnormalities after long-term intermittent hypoxia. The Journal of Physiology. PMID 27506145 DOI: 10.1113/Jp272346  0.41
2016 Wang GL, Semenza GL. Oxygen sensing and response to hypoxia by mammalian cells. Redox Report : Communications in Free Radical Research. 2: 89-96. PMID 27405946 DOI: 10.1080/13510002.1996.11747034  0.53
2016 Samanta D, Park Y, Andrabi SA, Shelton LM, Gilkes DM, Semenza GL. PHGDH Expression is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance and Lung Metastasis. Cancer Research. PMID 27280394 DOI: 10.1158/0008-5472.Can-16-0530  0.842
2016 Bullen JW, Tchernyshyov I, Holewinski RJ, DeVine L, Wu F, Venkatraman V, Kass DL, Cole RN, Van Eyk J, Semenza GL. Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1. Science Signaling. 9: ra56. PMID 27245613 DOI: 10.1126/Scisignal.Aaf0583  0.536
2016 Zhang C, Samanta D, Lu H, Bullen JW, Zhang H, Chen I, He X, Semenza GL. Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA. Proceedings of the National Academy of Sciences of the United States of America. PMID 27001847 DOI: 10.1073/Pnas.1602883113  0.587
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin J, Abeliovich H, Arozena AA, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Semenza GL, et al. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 Autophagy. 12: 443-443. PMID 26902590 DOI: 10.1080/15548627.2016.1147886  0.75
2016 Luo W, Chen I, Chen Y, Alkam D, Wang Y, Semenza GL. PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia. Oncotarget. PMID 26837221 DOI: 10.18632/Oncotarget.7142  0.756
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... Semenza GL, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.772
2016 Semenza GL. Novel strategies for cancer therapy. Journal of Molecular Medicine (Berlin, Germany). 94: 119-20. PMID 26780330 DOI: 10.1007/S00109-016-1379-2  0.409
2016 Hu K, Babapoor-Farrokhran S, Rodrigues M, Deshpande M, Puchner B, Kashiwabuchi F, Hassan SJ, Asnaghi L, Handa JT, Merbs S, Eberhart CG, Semenza GL, Montaner S, Sodhi A. Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma. Oncotarget. PMID 26761211 DOI: 10.18632/Oncotarget.6868  0.511
2016 Semenza GL, Ruvolo PP. Introduction to tumor microenvironment regulation of cancer cell survival, metastasis, inflammation, and immune surveillance. Biochimica Et Biophysica Acta. 1863: 379-81. PMID 26721622 DOI: 10.1016/J.Bbamcr.2015.12.015  0.463
2016 Johns RA, Takimoto E, Meuchel LW, Elsaigh E, Zhang A, Heller NM, Semenza GL, Yamaji-Kegan K. Hypoxia-Inducible Factor 1α Is a Critical Downstream Mediator for Hypoxia-Induced Mitogenic Factor (FIZZ1/RELMα)-Induced Pulmonary Hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology. 36: 134-44. PMID 26586659 DOI: 10.1161/Atvbaha.115.306710  0.464
2016 Semenza GL. Dynamic regulation of stem cell specification and maintenance by hypoxia-inducible factors. Molecular Aspects of Medicine. 47: 15-23. PMID 26549347 DOI: 10.1016/j.mam.2015.09.004  0.417
2016 Prabhakar NR, Semenza GL. Regulation of carotid body oxygen sensing by hypoxia-inducible factors. PflüGers Archiv : European Journal of Physiology. 468: 71-5. PMID 26265380 DOI: 10.1007/S00424-015-1719-Z  0.473
2016 Semenza GL. The hypoxic tumor microenvironment: A driving force for breast cancer progression. Biochimica Et Biophysica Acta. 1863: 382-91. PMID 26079100 DOI: 10.1016/J.Bbamcr.2015.05.036  0.583
2016 Semenza GL. Targeting hypoxia-inducible factor 1 to stimulate tissue vascularization. Journal of Investigative Medicine : the Official Publication of the American Federation For Clinical Research. 64: 361-3. PMID 25955799 DOI: 10.1097/Jim.0000000000000206  0.518
2016 Zhi W, Huang C, Gabrielson E, Tully E, Cimino-Mathews A, Santa-Maria C, Jeter S, Kai C, Semenza G, Stearns V. Abstract P3-07-62: Association of overexpression of hypoxia inducible factor 1α with response to neoadjuvant chemotherapy in early stage breast cancer Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P3-07-62  0.525
2015 Zhang H, Lu H, Xiang L, Bullen JW, Zhang C, Samanta D, Gilkes DM, He J, Semenza GL. HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 26512116 DOI: 10.1073/Pnas.1520032112  0.824
2015 Hubbi ME, Semenza GL. Regulation of cell proliferation by hypoxia-inducible factors. American Journal of Physiology. Cell Physiology. 309: C775-82. PMID 26491052 DOI: 10.1152/Ajpcell.00279.2015  0.783
2015 Semenza GL. Regulation of the breast cancer stem cell phenotype by hypoxia-inducible factors. Clinical Science (London, England : 1979). 129: 1037-45. PMID 26405042 DOI: 10.1042/CS20150451  0.499
2015 Semenza GL. AJP-Cell Theme: Cellular Responses to Hypoxia. American Journal of Physiology. Cell Physiology. 309: C349. PMID 26374688 DOI: 10.1152/Ajpcell.Zh0-7805-Editorial.2015  0.455
2015 Prabhakar NR, Semenza GL. Oxygen Sensing and Homeostasis. Physiology (Bethesda, Md.). 30: 340-8. PMID 26328879 DOI: 10.1152/Physiol.00022.2015  0.441
2015 Ganten D, Semenza G, Sommer T. 151 years Berliner Klinische Wochenschrift and the 20th anniversary of the Journal of Molecular Medicine. Journal of Molecular Medicine (Berlin, Germany). 93: 935-6. PMID 26260526 DOI: 10.1007/S00109-015-1324-9  0.307
2015 Lu H, Samanta D, Xiang L, Zhang H, Hu H, Chen I, Bullen JW, Semenza GL. Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype. Proceedings of the National Academy of Sciences of the United States of America. 112: E4600-9. PMID 26229077 DOI: 10.1073/Pnas.1513433112  0.584
2015 Ma T, Patel H, Babapoor-Farrokhran S, Franklin R, Semenza GL, Sodhi A, Montaner S. KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi's sarcoma. Angiogenesis. PMID 26092770 DOI: 10.1007/S10456-015-9475-4  0.514
2015 Xiang L, Gilkes DM, Hu H, Luo W, Bullen JW, Liang H, Semenza GL. HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells. Oncotarget. 6: 11768-78. PMID 26059435 DOI: 10.18632/Oncotarget.4190  0.838
2015 Babapoor-Farrokhran S, Jee K, Puchner B, Hassan SJ, Xin X, Rodrigues M, Kashiwabuchi F, Ma T, Hu K, Deshpande M, Daoud Y, Solomon S, Wenick A, Lutty GA, Semenza GL, et al. Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy. Proceedings of the National Academy of Sciences of the United States of America. 112: E3030-9. PMID 26039997 DOI: 10.1073/Pnas.1423765112  0.428
2015 Semenza GL, Prabhakar NR. Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea. Journal of Applied Physiology (Bethesda, Md. : 1985). 119: 1152-6. PMID 25953833 DOI: 10.1152/Japplphysiol.00162.2015  0.458
2015 Hubbi ME, Semenza GL. An essential role for chaperone-mediated autophagy in cell cycle progression. Autophagy. 11: 850-1. PMID 25945892 DOI: 10.1080/15548627.2015.1037063  0.769
2015 Yuan G, Vasavda C, Peng YJ, Makarenko VV, Raghuraman G, Nanduri J, Gadalla MM, Semenza GL, Kumar GK, Snyder SH, Prabhakar NR. Protein kinase G-regulated production of H2S governs oxygen sensing. Science Signaling. 8: ra37. PMID 25900831 DOI: 10.1126/Scisignal.2005846  0.393
2015 Wang J, Fu X, Yang K, Jiang Q, Chen Y, Jia J, Duan X, Wang EW, He J, Ran P, Zhong N, Semenza GL, Lu W. Hypoxia inducible factor-1-dependent up-regulation of BMP4 mediates hypoxia-induced increase of TRPC expression in PASMCs. Cardiovascular Research. 107: 108-18. PMID 25824146 DOI: 10.1093/Cvr/Cvv122  0.469
2015 Nanduri J, Vaddi DR, Khan SA, Wang N, Makarenko V, Semenza GL, Prabhakar NR. HIF-1α activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase. Plos One. 10: e0119762. PMID 25751622 DOI: 10.1371/Journal.Pone.0119762  0.479
2015 Liu ZJ, Semenza GL, Zhang HF. Hypoxia-inducible factor 1 and breast cancer metastasis. Journal of Zhejiang University. Science. B. 16: 32-43. PMID 25559953 DOI: 10.1631/Jzus.B1400221  0.568
2015 Luo W, Semenza GL. Abstract 525: PHD3-mediated prolyl hydroxylation of non-muscle actin impairs polymerization and cell motility Cancer Research. 75: 525-525. DOI: 10.1158/1538-7445.Am2015-525  0.679
2015 Lu H, Samanta D, Xiang L, Zhang H, Hu H, Chen I, Bullen JW, Semenza GL. Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype Proceedings of the National Academy of Sciences of the United States of America. 112: E4600-E4609. DOI: 10.1073/pnas.1513433112  0.442
2014 Xiang L, Gilkes DM, Hu H, Takano N, Luo W, Lu H, Bullen JW, Samanta D, Liang H, Semenza GL. Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. Oncotarget. 5: 12509-27. PMID 25587023 DOI: 10.18632/Oncotarget.2997  0.856
2014 Samanta D, Gilkes DM, Chaturvedi P, Xiang L, Semenza GL. Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E5429-38. PMID 25453096 DOI: 10.1073/Pnas.1421438111  0.84
2014 Hu H, Takano N, Xiang L, Gilkes DM, Luo W, Semenza GL. Hypoxia-inducible factors enhance glutamate signaling in cancer cells. Oncotarget. 5: 8853-68. PMID 25326682 DOI: 10.18632/Oncotarget.2593  0.82
2014 Chapiro J, Sur S, Savic LJ, Ganapathy-Kanniappan S, Reyes J, Duran R, Thiruganasambandam SC, Moats CR, Lin M, Luo W, Tran PT, Herman JM, Semenza GL, Ewald AJ, Vogelstein B, et al. Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 6406-17. PMID 25326230 DOI: 10.1158/1078-0432.Ccr-14-1271  0.694
2014 Huang D, Li T, Li X, Zhang L, Sun L, He X, Zhong X, Jia D, Song L, Semenza GL, Gao P, Zhang H. HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression. Cell Reports. 8: 1930-42. PMID 25242319 DOI: 10.1016/J.Celrep.2014.08.028  0.539
2014 Lorenzo FR, Huff C, Myllymäki M, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuren T, Ri-Li G, McClain DA, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, ... Semenza GL, et al. A genetic mechanism for Tibetan high-altitude adaptation. Nature Genetics. 46: 951-6. PMID 25129147 DOI: 10.1038/Ng.3067  0.574
2014 Luo W, Lin B, Wang Y, Zhong J, O'Meally R, Cole RN, Pandey A, Levchenko A, Semenza GL. PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility. Molecular Biology of the Cell. 25: 2788-96. PMID 25079693 DOI: 10.1091/Mbc.E14-02-0775  0.67
2014 Hubbi ME, Gilkes DM, Hu H, Kshitiz, Ahmed I, Semenza GL. Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression. Proceedings of the National Academy of Sciences of the United States of America. 111: E3325-34. PMID 25071185 DOI: 10.1073/Pnas.1412840111  0.817
2014 Takano N, Sarfraz Y, Gilkes DM, Chaturvedi P, Xiang L, Suematsu M, Zagzag D, Semenza GL. Decreased expression of cystathionine β-synthase promotes glioma tumorigenesis. Molecular Cancer Research : McR. 12: 1398-406. PMID 24994751 DOI: 10.1158/1541-7786.Mcr-14-0184  0.814
2014 Peng YJ, Yuan G, Khan S, Nanduri J, Makarenko VV, Reddy VD, Vasavda C, Kumar GK, Semenza GL, Prabhakar NR. Regulation of hypoxia-inducible factor-α isoforms and redox state by carotid body neural activity in rats. The Journal of Physiology. 592: 3841-58. PMID 24973414 DOI: 10.1113/Jphysiol.2014.273789  0.481
2014 Wang T, Gilkes DM, Takano N, Xiang L, Luo W, Bishop CJ, Chaturvedi P, Green JJ, Semenza GL. Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis. Proceedings of the National Academy of Sciences of the United States of America. 111: E3234-42. PMID 24938788 DOI: 10.1073/Pnas.1410041111  0.838
2014 Jiang X, Sung YK, Tian W, Qian J, Semenza GL, Nicolls MR. Graft microvascular disease in solid organ transplantation. Journal of Molecular Medicine (Berlin, Germany). 92: 797-810. PMID 24880953 DOI: 10.1007/S00109-014-1173-Y  0.363
2014 Yang C, Jiang L, Zhang H, Shimoda LA, DeBerardinis RJ, Semenza GL. Analysis of hypoxia-induced metabolic reprogramming. Methods in Enzymology. 542: 425-55. PMID 24862279 DOI: 10.1016/B978-0-12-416618-9.00022-4  0.471
2014 Gilkes DM, Semenza GL, Wirtz D. Hypoxia and the extracellular matrix: drivers of tumour metastasis. Nature Reviews. Cancer. 14: 430-9. PMID 24827502 DOI: 10.1038/Nrc3726  0.8
2014 Chaturvedi P, Gilkes DM, Takano N, Semenza GL. Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment. Proceedings of the National Academy of Sciences of the United States of America. 111: E2120-9. PMID 24799675 DOI: 10.1073/Pnas.1406655111  0.823
2014 Takano N, Peng YJ, Kumar GK, Luo W, Hu H, Shimoda LA, Suematsu M, Prabhakar NR, Semenza GL. Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression. The Biochemical Journal. 458: 203-11. PMID 24328859 DOI: 10.1042/Bj20131350  0.734
2014 Gilkes DM, Xiang L, Lee SJ, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL. Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E384-93. PMID 24324133 DOI: 10.1073/Pnas.1321510111  0.834
2014 Xiang L, Gilkes DM, Chaturvedi P, Luo W, Hu H, Takano N, Liang H, Semenza GL. Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer. Journal of Molecular Medicine (Berlin, Germany). 92: 151-64. PMID 24248265 DOI: 10.1007/S00109-013-1102-5  0.845
2014 Jiang X, Malkovskiy AV, Tian W, Sung YK, Sun W, Hsu JL, Manickam S, Wagh D, Joubert LM, Semenza GL, Rajadas J, Nicolls MR. Promotion of airway anastomotic microvascular regeneration and alleviation of airway ischemia by deferoxamine nanoparticles. Biomaterials. 35: 803-13. PMID 24161166 DOI: 10.1016/J.Biomaterials.2013.09.092  0.437
2014 Semenza GL. Hypoxia-inducible factor 1 and cardiovascular disease. Annual Review of Physiology. 76: 39-56. PMID 23988176 DOI: 10.1146/Annurev-Physiol-021113-170322  0.468
2014 Semenza GL. Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology. Annual Review of Pathology. 9: 47-71. PMID 23937437 DOI: 10.1146/annurev-pathol-012513-104720  0.381
2013 Gilkes DM, Semenza GL. Role of hypoxia-inducible factors in breast cancer metastasis. Future Oncology (London, England). 9: 1623-36. PMID 24156323 DOI: 10.2217/Fon.13.92  0.846
2013 Iwase T, Fu J, Yoshida T, Muramatsu D, Miki A, Hashida N, Lu L, Oveson B, Lima e Silva R, Seidel C, Yang M, Connelly S, Shen J, Han B, Wu M, ... Semenza GL, et al. Sustained delivery of a HIF-1 antagonist for ocular neovascularization. Journal of Controlled Release : Official Journal of the Controlled Release Society. 172: 625-33. PMID 24126220 DOI: 10.1016/J.Jconrel.2013.10.008  0.396
2013 Cai Z, Luo W, Zhan H, Semenza GL. Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart. Proceedings of the National Academy of Sciences of the United States of America. 110: 17462-7. PMID 24101519 DOI: 10.1073/Pnas.1317158110  0.685
2013 Semenza GL. HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. The Journal of Clinical Investigation. 123: 3664-71. PMID 23999440 DOI: 10.1172/Jci67230  0.497
2013 Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, ... ... Semenza GL, et al. The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3. Immunity. 39: 272-85. PMID 23973223 DOI: 10.1016/J.Immuni.2013.08.006  0.691
2013 Xin X, Rodrigues M, Umapathi M, Kashiwabuchi F, Ma T, Babapoor-Farrokhran S, Wang S, Hu J, Bhutto I, Welsbie DS, Duh EJ, Handa JT, Eberhart CG, Lutty G, Semenza GL, et al. Hypoxic retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4. Proceedings of the National Academy of Sciences of the United States of America. 110: E3425-34. PMID 23959876 DOI: 10.1073/Pnas.1217091110  0.505
2013 Rodrigues M, Xin X, Jee K, Babapoor-Farrokhran S, Kashiwabuchi F, Ma T, Bhutto I, Hassan SJ, Daoud Y, Baranano D, Solomon S, Lutty G, Semenza GL, Montaner S, Sodhi A. VEGF secreted by hypoxic Müller cells induces MMP-2 expression and activity in endothelial cells to promote retinal neovascularization in proliferative diabetic retinopathy. Diabetes. 62: 3863-73. PMID 23884892 DOI: 10.2337/Db13-0014  0.443
2013 Jiang X, Hsu JL, Tian W, Yuan K, Olcholski M, Perez Vde J, Semenza GL, Nicolls MR. Tie2-dependent VHL knockdown promotes airway microvascular regeneration and attenuates invasive growth of Aspergillus fumigatus. Journal of Molecular Medicine (Berlin, Germany). 91: 1081-93. PMID 23797537 DOI: 10.1007/S00109-013-1063-8  0.491
2013 Du J, Liu L, Lay F, Wang Q, Dou C, Zhang X, Hosseini SM, Simon A, Rees DJ, Ahmed AK, Sebastian R, Sarkar K, Milner S, Marti GP, Semenza GL, et al. Combination of HIF-1α gene transfection and HIF-1-Activated bone marrow-derived angiogenic cell infusion improves burn wound healing in aged mice Gene Therapy. 20: 1070-1076. PMID 23784441 DOI: 10.1038/Gt.2013.32  0.467
2013 Hubbi ME, Hu H, Kshitiz, Gilkes DM, Semenza GL. Sirtuin-7 inhibits the activity of hypoxia-inducible factors. The Journal of Biological Chemistry. 288: 20768-75. PMID 23750001 DOI: 10.1074/Jbc.M113.476903  0.821
2013 Bohuslavova R, Skvorova L, Sedmera D, Semenza GL, Pavlinkova G. Increased susceptibility of HIF-1α heterozygous-null mice to cardiovascular malformations associated with maternal diabetes. Journal of Molecular and Cellular Cardiology. 60: 129-41. PMID 23619295 DOI: 10.1016/J.Yjmcc.2013.04.015  0.398
2013 Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, ... ... Semenza GL, et al. A physical sciences network characterization of non-tumorigenic and metastatic cells. Scientific Reports. 3: 1449. PMID 23618955 DOI: 10.1038/Srep01449  0.58
2013 Yuan G, Peng YJ, Reddy VD, Makarenko VV, Nanduri J, Khan SA, Garcia JA, Kumar GK, Semenza GL, Prabhakar NR. Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 110: E1788-96. PMID 23610397 DOI: 10.1073/Pnas.1305961110  0.488
2013 Gilkes DM, Chaturvedi P, Bajpai S, Wong CC, Wei H, Pitcairn S, Hubbi ME, Wirtz D, Semenza GL. Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Research. 73: 3285-96. PMID 23539444 DOI: 10.1158/0008-5472.Can-12-3963  0.834
2013 Semenza GL. Advances in cancer biology and therapy. Journal of Molecular Medicine (Berlin, Germany). 91: 409. PMID 23515622 DOI: 10.1007/S00109-013-1024-2  0.508
2013 Hubbi ME, Hu H, Kshitiz, Ahmed I, Levchenko A, Semenza GL. Chaperone-mediated autophagy targets hypoxia-inducible factor-1α (HIF-1α) for lysosomal degradation. The Journal of Biological Chemistry. 288: 10703-14. PMID 23457305 DOI: 10.1074/Jbc.M112.414771  0.798
2013 Semenza GL. Blood vessels, disease pathogenesis, and novel therapies. Journal of Molecular Medicine (Berlin, Germany). 91: 283. PMID 23430241 DOI: 10.1007/S00109-013-1009-1  0.328
2013 Gilkes DM, Bajpai S, Chaturvedi P, Wirtz D, Semenza GL. Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts. The Journal of Biological Chemistry. 288: 10819-29. PMID 23423382 DOI: 10.1074/Jbc.M112.442939  0.838
2013 Pisarcik S, Maylor J, Lu W, Yun X, Undem C, Sylvester JT, Semenza GL, Shimoda LA. Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1. American Journal of Physiology. Lung Cellular and Molecular Physiology. 304: L549-61. PMID 23418090 DOI: 10.1152/Ajplung.00081.2012  0.528
2013 Hubbi ME, Kshitiz, Gilkes DM, Rey S, Wong CC, Luo W, Kim DH, Dang CV, Levchenko A, Semenza GL. A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication Science Signaling. 6. PMID 23405012 DOI: 10.1126/Scisignal.2003417  0.803
2013 Gilkes DM, Bajpai S, Wong CC, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL. Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. Molecular Cancer Research : McR. 11: 456-66. PMID 23378577 DOI: 10.1158/1541-7786.Mcr-12-0629  0.831
2013 Drager LF, Yao Q, Hernandez KL, Shin MK, Bevans-Fonti S, Gay J, Sussan TE, Jun JC, Myers AC, Olivecrona G, Schwartz AR, Halberg N, Scherer PE, Semenza GL, Powell DR, et al. Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4. American Journal of Respiratory and Critical Care Medicine. 188: 240-8. PMID 23328524 DOI: 10.1164/Rccm.201209-1688Oc  0.409
2013 Chaturvedi P, Gilkes DM, Wong CC, Luo W, Zhang H, Wei H, Takano N, Schito L, Levchenko A, Semenza GL. Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. The Journal of Clinical Investigation. 123: 189-205. PMID 23318994 DOI: 10.1172/Jci64993  0.845
2013 Semenza GL. Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis. Oncogene. 32: 4057-63. PMID 23222717 DOI: 10.1038/Onc.2012.578  0.581
2013 Bardia A, Santa-Maria CA, Jacobs LK, Cimino-Mathews A, Huang P, Russell S, Camp M, Habibi M, Lange JR, Jeter S, Powers P, Slater S, Gabrielson E, Carducci MA, Semenza G, et al. Digoxin as an inhibitor of global hypoxia inducible factor-1α (HIF1α) expression and downstream targets in breast cancer: Dig-HIF1 pharmacodynamic trial. Journal of Clinical Oncology. 31: TPS1144-TPS1144. DOI: 10.1200/Jco.2013.31.15_Suppl.Tps1144  0.526
2013 Chaturvedi P, Gilkes DM, Wong CCL, Kshitiz, Luo W, Zhang H, Wei H, Takano N, Schito L, Levchenko A, Semenza GL. Erratum: Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis (Journal of Clinical Investigation (2013) 123: 1 (189-205) DOI: 10.1172/JCI64993) Journal of Clinical Investigation. 123. DOI: 10.1172/Jci69244  0.83
2013 Gilkes DM, Chaturvedi P, Wong C, Bajpai S, Wei H, Hubbi M, Wirtz D, Semenza G. Abstract A3: Collagen hydroxylases are essential for breast cancer metastasis Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-A3  0.828
2013 Chaturvedi P, Gilkes D, Semenza G. Abstract 505: Hypoxia inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. Cancer Research. 73: 505-505. DOI: 10.1158/1538-7445.Am2013-505  0.85
2013 Gilkes DM, Chaturvedi P, Bajpai S, Hubbi M, Wirtz D, Semenza G. Abstract 3937: Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Research. 73: 3937-3937. DOI: 10.1158/1538-7445.Am2013-3937  0.829
2013 Luo W, Chang R, Zhong J, Pandey A, Semenza GL. Abstract 2319: Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. Cancer Research. 73: 2319-2319. DOI: 10.1158/1538-7445.Am2013-2319  0.776
2013 Semenza GL, Hubbi ME, VanHook AM. Science Signaling Podcast: 12 February 2013 Science Signaling. 6: pc5-pc5. DOI: 10.1126/Scisignal.2004007  0.788
2012 Luo W, Chang R, Zhong J, Pandey A, Semenza GL. Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 109: E3367-76. PMID 23129632 DOI: 10.1073/Pnas.1217394109  0.776
2012 Semenza GL, Prabhakar NR. The role of hypoxia-inducible factors in oxygen sensing by the carotid body. Advances in Experimental Medicine and Biology. 758: 1-5. PMID 23080136 DOI: 10.1007/978-94-007-4584-1_1  0.503
2012 Schito L, Rey S, Tafani M, Zhang H, Wong CCL, Russo A, Russo MA, Semenza GL. Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells Proceedings of the National Academy of Sciences of the United States of America. 109: E2707-E2716. PMID 23012449 DOI: 10.1073/Pnas.1214019109  0.846
2012 Krishnamachary B, Penet MF, Nimmagadda S, Mironchik Y, Raman V, Solaiyappan M, Semenza GL, Pomper MG, Bhujwalla ZM. Hypoxia regulates CD44 and its variant isoforms through HIF-1α in triple negative breast cancer. Plos One. 7: e44078. PMID 22937154 DOI: 10.1371/Journal.Pone.0044078  0.524
2012 Semenza GL. Molecular mechanisms mediating metastasis of hypoxic breast cancer cells. Trends in Molecular Medicine. 18: 534-43. PMID 22921864 DOI: 10.1016/J.Molmed.2012.08.001  0.603
2012 Luo W, Semenza GL. Emerging roles of PKM2 in cell metabolism and cancer progression. Trends in Endocrinology and Metabolism: Tem. 23: 560-6. PMID 22824010 DOI: 10.1016/J.Tem.2012.06.010  0.721
2012 Prabhakar NR, Semenza GL. Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiological Reviews. 92: 967-1003. PMID 22811423 DOI: 10.1152/Physrev.00030.2011  0.522
2012 Sarkar K, Cai Z, Gupta R, Parajuli N, Fox-Talbot K, Darshan MS, Gonzalez FJ, Semenza GL. Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning. Proceedings of the National Academy of Sciences of the United States of America. 109: 10504-9. PMID 22699503 DOI: 10.1073/Pnas.1208314109  0.513
2012 Kshitiz, Hubbi ME, Ahn EH, Downey J, Afzal J, Kim DH, Rey S, Chang C, Kundu A, Semenza GL, Abraham RM, Levchenko A. Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors. Science Signaling. 5: ra41. PMID 22669846 DOI: 10.1126/Scisignal.2003002  0.795
2012 Wei H, Bedja D, Koitabashi N, Xing D, Chen J, Fox-Talbot K, Rouf R, Chen S, Steenbergen C, Harmon JW, Dietz HC, Gabrielson KL, Kass DA, Semenza GL. Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-β signaling. Proceedings of the National Academy of Sciences of the United States of America. 109: E841-50. PMID 22403061 DOI: 10.1073/Pnas.1202081109  0.461
2012 Semenza GL. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends in Pharmacological Sciences. 33: 207-14. PMID 22398146 DOI: 10.1016/J.Tips.2012.01.005  0.549
2012 Semenza GL, Prabhakar NR. Gas biology: small molecular medicine. Journal of Molecular Medicine (Berlin, Germany). 90: 213-5. PMID 22349395 DOI: 10.1007/S00109-012-0877-0  0.465
2012 Prabhakar NR, Semenza GL. Gaseous messengers in oxygen sensing. Journal of Molecular Medicine (Berlin, Germany). 90: 265-72. PMID 22349394 DOI: 10.1007/S00109-012-0876-1  0.464
2012 Semenza GL. Hypoxia-inducible factors in physiology and medicine. Cell. 148: 399-408. PMID 22304911 DOI: 10.1016/J.Cell.2012.01.021  0.506
2012 Abud EM, Maylor J, Undem C, Punjabi A, Zaiman AL, Myers AC, Sylvester JT, Semenza GL, Shimoda LA. Digoxin inhibits development of hypoxic pulmonary hypertension in mice. Proceedings of the National Academy of Sciences of the United States of America. 109: 1239-44. PMID 22232678 DOI: 10.1073/Pnas.1120385109  0.427
2012 Nanduri J, Makarenko V, Reddy VD, Yuan G, Pawar A, Wang N, Khan SA, Zhang X, Kinsman B, Peng YJ, Kumar GK, Fox AP, Godley LA, Semenza GL, Prabhakar NR. Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 109: 2515-20. PMID 22232674 DOI: 10.1073/Pnas.1120600109  0.425
2012 Wong CC, Zhang H, Gilkes DM, Chen J, Wei H, Chaturvedi P, Hubbi ME, Semenza GL. Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. Journal of Molecular Medicine (Berlin, Germany). 90: 803-15. PMID 22231744 DOI: 10.1007/S00109-011-0855-Y  0.839
2012 Hubbi ME, Gilkes DM, Baek JH, Semenza GL. Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1. The Journal of Biological Chemistry. 287: 6139-49. PMID 22219185 DOI: 10.1074/Jbc.M111.278630  0.821
2012 Sarkar K, Rey S, Zhang X, Sebastian R, Marti GP, Fox-Talbot K, Cardona AV, Du J, Tan YS, Liu L, Lay F, Gonzalez FJ, Harmon JW, Semenza GL. Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells. Cardiovascular Research. 93: 162-9. PMID 22028336 DOI: 10.1093/Cvr/Cvr282  0.755
2012 Zhang H, Wong CC, Wei H, Gilkes DM, Korangath P, Chaturvedi P, Schito L, Chen J, Krishnamachary B, Winnard PT, Raman V, Zhen L, Mitzner WA, Sukumar S, Semenza GL. HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene. 31: 1757-70. PMID 21860410 DOI: 10.1038/Onc.2011.365  0.833
2012 Semenza GL. Transcriptional regulation by hypoxia-inducible factor 1 molecular mechanisms of oxygen homeostasis. Trends in Cardiovascular Medicine. 6: 151-7. PMID 21232289 DOI: 10.1016/1050-1738(96)00039-4  0.522
2012 V FRL, Huff CD, Myllymäki M, Swierczek S, Salama ME, Semenza G, Gordeuk VR, Jorde L, Koivunen P, Prchal JT. A Novel EGLN1/PHD2 High-Frequency Variant in Tibetans Protects Against Hypoxia-Induced Polycythemia. Blood. 120: 2079-2079. DOI: 10.1182/Blood.V120.21.2079.2079  0.48
2012 Kshitiz, Hubbi ME, Ahn EH, Downey J, Afzal J, Kim DH, Rey S, Chang C, Kundu A, Semenza GL, Abraham RM, Levchenko A. Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors (Science Signaling (2012) 5) Science Signaling. 5. DOI: 10.1126/Scisignal.5245Er6  0.768
2012 Semenza GL. Shifting paradigms for ischaemic preconditioning: AUTHOR'S RETROSPECTIVE Cardiovascular Research. 96: 216-219. DOI: 10.1093/Cvr/Cvs197  0.394
2011 Suda T, Takubo K, Semenza GL. Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell. 9: 298-310. PMID 21982230 DOI: 10.1016/J.Stem.2011.09.010  0.392
2011 Wong CC, Gilkes DM, Zhang H, Chen J, Wei H, Chaturvedi P, Fraley SI, Wong CM, Khoo US, Ng IO, Wirtz D, Semenza GL. Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proceedings of the National Academy of Sciences of the United States of America. 108: 16369-74. PMID 21911388 DOI: 10.1073/Pnas.1113483108  0.84
2011 Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y, Yen HR, Luo W, Zeller K, Shimoda L, Topalian SL, Semenza GL, et al. Control of TH17/Treg balance by hypoxia-inducible factor 1 Cell. 146: 772-784. PMID 21871655 DOI: 10.1016/J.Cell.2011.07.033  0.661
2011 Hattori H, Okuda K, Murase T, Shigetsura Y, Narise K, Semenza GL, Nagasawa H. Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis. Bioorganic & Medicinal Chemistry. 19: 5392-401. PMID 21865046 DOI: 10.1016/J.Bmc.2011.07.060  0.494
2011 Semenza GL. Oxygen sensing, homeostasis, and disease. The New England Journal of Medicine. 365: 537-47. PMID 21830968 DOI: 10.1056/Nejmra1011165  0.507
2011 Semenza GL. Regulation of metabolism by hypoxia-inducible factor 1. Cold Spring Harbor Symposia On Quantitative Biology. 76: 347-53. PMID 21785006 DOI: 10.1101/Sqb.2011.76.010678  0.543
2011 Luo W, Semenza GL. Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells. Oncotarget. 2: 551-6. PMID 21709315 DOI: 10.18632/Oncotarget.299  0.729
2011 Semenza GL. Hypoxia. Cross talk between oxygen sensing and the cell cycle machinery. American Journal of Physiology. Cell Physiology. 301: C550-2. PMID 21677261 DOI: 10.1152/Ajpcell.00176.2011  0.512
2011 Hubbi ME, Luo W, Baek JH, Semenza GL. MCM proteins are negative regulators of hypoxia-inducible factor 1. Molecular Cell. 42: 700-12. PMID 21658608 DOI: 10.1016/J.Molcel.2011.03.029  0.826
2011 Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole RN, Pandey A, Semenza GL. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell. 145: 732-44. PMID 21620138 DOI: 10.1016/J.Cell.2011.03.054  0.75
2011 Jiang X, Khan MA, Tian W, Beilke J, Natarajan R, Kosek J, Yoder MC, Semenza GL, Nicolls MR. Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection. The Journal of Clinical Investigation. 121: 2336-49. PMID 21606594 DOI: 10.1172/Jci46192  0.447
2011 Zhang X, Sarkar K, Rey S, Sebastian R, Andrikopoulou E, Marti GP, Fox-Talbot K, Semenza GL, Harmon JW. Aging impairs the mobilization and homing of bone marrow-derived angiogenic cells to burn wounds. Journal of Molecular Medicine (Berlin, Germany). 89: 985-95. PMID 21499736 DOI: 10.1007/S00109-011-0754-2  0.707
2011 Rangasamy T, Semenza GL, Georas SN. What is hypoxia-inducible factor-1 doing in the allergic lung? Allergy. 66: 815-7. PMID 21480925 DOI: 10.1111/j.1398-9995.2011.02593.x  0.33
2011 Rey S, Luo W, Shimoda LA, Semenza GL. Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue Blood. 117: 4988-4998. PMID 21389314 DOI: 10.1182/Blood-2010-11-321190  0.809
2011 Keswani SC, Bosch-Marcé M, Reed N, Fischer A, Semenza GL, Höke A. Nitric oxide prevents axonal degeneration by inducing HIF-1-dependent expression of erythropoietin. Proceedings of the National Academy of Sciences of the United States of America. 108: 4986-90. PMID 21383158 DOI: 10.1073/Pnas.1019591108  0.723
2011 Yuan G, Khan SA, Luo W, Nanduri J, Semenza GL, Prabhakar NR. Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia. Journal of Cellular Physiology. 226: 2925-33. PMID 21302291 DOI: 10.1002/Jcp.22640  0.733
2011 Semenza GL. A return to cancer metabolism. Journal of Molecular Medicine (Berlin, Germany). 89: 203-4. PMID 21301793 DOI: 10.1007/S00109-011-0733-7  0.412
2011 Peng YJ, Nanduri J, Khan SA, Yuan G, Wang N, Kinsman B, Vaddi DR, Kumar GK, Garcia JA, Semenza GL, Prabhakar NR. Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Proceedings of the National Academy of Sciences of the United States of America. 108: 3065-70. PMID 21288809 DOI: 10.1073/Pnas.1100064108  0.483
2011 Shimoda LA, Semenza GL. HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease. American Journal of Respiratory and Critical Care Medicine. 183: 152-6. PMID 21242594 DOI: 10.1164/Rccm.201009-1393Pp  0.475
2011 Kannan KB, Colorado I, Reino D, Palange D, Lu Q, Qin X, Abungu B, Watkins A, Caputo FJ, Xu DZ, Semenza GL, Deitch EA, Feinman R. Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury. American Journal of Physiology. Gastrointestinal and Liver Physiology. 300: G853-61. PMID 21183660 DOI: 10.1152/Ajpgi.00459.2010  0.417
2011 Semenza GL. American Journal of Physiology-Cell Physiology theme: hypoxia. American Journal of Physiology. Cell Physiology. 300: C225. PMID 21084643 DOI: 10.1152/Ajpcell.00468.2010  0.419
2011 Semenza GL. Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning. Biochimica Et Biophysica Acta. 1813: 1263-8. PMID 20732359 DOI: 10.1016/J.Bbamcr.2010.08.006  0.48
2011 Korangath PC, Zhang H, Zhang Z, Huso D, Stearns V, Dang C, Semenza G, Sukumar S. Abstract 4088: Targeting glutamine metabolism in breast cancer Cancer Research. 71: 4088-4088. DOI: 10.1158/1538-7445.Am2011-4088  0.523
2011 Wong CCL, Gilkes D, Zhang H, Chen J, Chaturvedi P, Fraley S, Semenza GL. Abstract 1521: Hypoxia inducible factor is an important regulator of metastatic niche formation Cancer Research. 71: 1521-1521. DOI: 10.1158/1538-7445.Am2011-1521  0.851
2011 Sebastian R, Rey S, Zhang X, Sarkar K, Liu L, Marti GP, Amin F, Junkai D, Semenza GL, Harmon JW. Burn wound homing of bone marrow-derived angiogenic cells is impaired by conditional knock out of the hypoxia-inducible factor 1beta gene Journal of the American College of Surgeons. 213: S87-S88. DOI: 10.1016/J.Jamcollsurg.2011.06.409  0.717
2010 Guan Y, Ramasamy Reddy K, Zhu Q, Li Y, Lee K, Weerasinghe P, Prchal J, Semenza GL, Jing N. G-rich Oligonucleotides Inhibit HIF-1α and HIF-2α and Block Tumor Growth. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 188-197. PMID 28178550 DOI: 10.1038/mt.2009.219  0.459
2010 Semenza GL. Oxygen homeostasis. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 2: 336-61. PMID 20836033 DOI: 10.1002/wsbm.69  0.416
2010 Feinman R, Deitch EA, Watkins AC, Abungu B, Colorado I, Kannan KB, Sheth SU, Caputo FJ, Lu Q, Ramanathan M, Attan S, Badami CD, Doucet D, Barlos D, Bosch-Marce M, ... Semenza GL, et al. HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury. American Journal of Physiology. Gastrointestinal and Liver Physiology. 299: G833-43. PMID 20689059 DOI: 10.1152/Ajpgi.00065.2010  0.718
2010 Lee JS, Kim Y, Kim IS, Kim B, Choi HJ, Lee JM, Shin HJ, Kim JH, Kim JY, Seo SB, Lee H, Binda O, Gozani O, Semenza GL, Kim M, et al. Negative regulation of hypoxic responses via induced Reptin methylation. Molecular Cell. 39: 71-85. PMID 20603076 DOI: 10.1016/J.Molcel.2010.06.008  0.42
2010 Zhang X, Wei X, Liu L, Marti GP, Ghanamah MS, Arshad MJ, Strom L, Spence R, Jeng J, Milner S, Harmon JW, Semenza GL. Association of increasing burn severity in mice with delayed mobilization of circulating angiogenic cells. Archives of Surgery (Chicago, Ill. : 1960). 145: 259-66. PMID 20231626 DOI: 10.1001/Archsurg.2009.285  0.369
2010 Rey S, Semenza GL. Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling Cardiovascular Research. 86: 236-242. PMID 20164116 DOI: 10.1093/Cvr/Cvq045  0.753
2010 Zhang X, Liu L, Wei X, Tan YS, Tong L, Chang R, Ghanamah MS, Reinblatt M, Marti GP, Harmon JW, Semenza GL. Impaired angiogenesis and mobilization of circulating angiogenic cells in HIF-1alpha heterozygous-null mice after burn wounding. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 18: 193-201. PMID 20163569 DOI: 10.1111/J.1524-475X.2010.00570.X  0.43
2010 Yoon D, Okhotin DV, Kim B, Okhotina Y, Okhotin DJ, Miasnikova GY, Sergueeva AI, Polyakova LA, Maslow A, Lee Y, Semenza GL, Prchal JT, Gordeuk VR. Increased size of solid organs in patients with Chuvash polycythemia and in mice with altered expression of HIF-1alpha and HIF-2alpha. Journal of Molecular Medicine (Berlin, Germany). 88: 523-30. PMID 20140661 DOI: 10.1007/S00109-010-0599-0  0.466
2010 Le A, Cooper CR, Gouw AM, Dinavahi R, Maitra A, Deck LM, Royer RE, Vander Jagt DL, Semenza GL, Dang CV. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proceedings of the National Academy of Sciences of the United States of America. 107: 2037-42. PMID 20133848 DOI: 10.1073/Pnas.0914433107  0.509
2010 Yoshida T, Zhang H, Iwase T, Shen J, Semenza GL, Campochiaro PA. Digoxin inhibits retinal ischemia-induced HIF-1alpha expression and ocular neovascularization. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 1759-67. PMID 20065104 DOI: 10.1096/Fj.09-145664  0.484
2010 Kojima H, Kobayashi A, Sakurai D, Kanno Y, Hase H, Takahashi R, Totsuka Y, Semenza GL, Sitkovsky MV, Kobata T. Differentiation stage-specific requirement in hypoxia-inducible factor-1alpha-regulated glycolytic pathway during murine B cell development in bone marrow. Journal of Immunology (Baltimore, Md. : 1950). 184: 154-63. PMID 19949104 DOI: 10.4049/Jimmunol.0800167  0.477
2010 Luo W, Zhong J, Chang R, Hu H, Pandey A, Semenza GL. Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha. The Journal of Biological Chemistry. 285: 3651-63. PMID 19940151 DOI: 10.1074/Jbc.M109.068577  0.696
2010 Ugocsai P, Hohenstatt A, Paragh G, Liebisch G, Langmann T, Wolf Z, Weiss T, Groitl P, Dobner T, Kasprzak P, Göbölös L, Falkert A, Seelbach-Goebel B, Gellhaus A, Winterhager E, ... ... Semenza GL, et al. HIF-1beta determines ABCA1 expression under hypoxia in human macrophages. The International Journal of Biochemistry & Cell Biology. 42: 241-52. PMID 19828131 DOI: 10.1016/J.Biocel.2009.10.002  0.455
2010 Guan Y, Reddy KR, Zhu Q, Li Y, Lee K, Weerasinghe P, Prchal J, Semenza GL, Jing N. G-rich oligonucleotides inhibit HIF-1alpha and HIF-2alpha and block tumor growth. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 188-97. PMID 19755960 DOI: 10.1038/Mt.2009.219  0.512
2010 Semenza GL. Vascular responses to hypoxia and ischemia. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 648-52. PMID 19729615 DOI: 10.1161/Atvbaha.108.181644  0.51
2010 Semenza GL. HIF-1 inhibitors for cancer therapy: from gene expression to drug discovery. Current Pharmaceutical Design. 15: 3839-43. PMID 19671047 DOI: 10.2174/138161209789649402  0.562
2010 Le A, Cooper CR, Gouw A, Maitra A, Dinavahi R, Deck L, Royer R, Jagt DV, Semenza G, Dang CV. Abstract 5453: Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression Cancer Research. 70: 5453-5453. DOI: 10.1158/1538-7445.Am10-5453  0.509
2010 Sarkar K, Fox-Talbot K, Steenbergen C, Bosch-Marcé M, Semenza GL. Adenoviral transfer of HIF-1α enhances vascular responses to critical limb ischemia in diabetic mice (Proceedings of the National Academy Sciences of United States of America (2009) 106, 44 (18769-18774) DOI: 10.1073/pnas. 0910561106) Proceedings of the National Academy of Sciences of the United States of America. 107. DOI: 10.1073/Pnas.0913116107  0.706
2010 Zhang X, Sarkar K, Andrikopoulou E, Xing D, Liu L, Reinblatt M, Laines RS, Marti GP, Semenza GL, Harmon JW. Delayed wound healing in aged mice is associated with diminished mobilization of circulating angiogenic cells Journal of the American College of Surgeons. 211: S78. DOI: 10.1016/J.Jamcollsurg.2010.06.205  0.363
2009 Rey S, Lee K, Wang CJ, Gupta K, Chen S, McMillan A, Bhise N, Levchenko A, Semenza GL. Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. Proceedings of the National Academy of Sciences of the United States of America. 106: 20399-404. PMID 19948968 DOI: 10.1073/Pnas.0911921106  0.753
2009 Semenza GL. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene. 29: 625-34. PMID 19946328 DOI: 10.1038/Onc.2009.441  0.566
2009 Semenza GL. HIF-1: upstream and downstream of cancer metabolism. Current Opinion in Genetics & Development. 20: 51-6. PMID 19942427 DOI: 10.1016/J.Gde.2009.10.009  0.506
2009 Semenza GL. Regulation of vascularization by hypoxia-inducible factor 1. Annals of the New York Academy of Sciences. 1177: 2-8. PMID 19845601 DOI: 10.1111/J.1749-6632.2009.05032.X  0.526
2009 Sarkar K, Fox-Talbot K, Steenbergen C, Bosch-Marcé M, Semenza GL. Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 18769-74. PMID 19841279 DOI: 10.1073/Pnas.0910561106  0.702
2009 Lee K, Zhang H, Qian DZ, Rey S, Liu JO, Semenza GL. Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Proceedings of the National Academy of Sciences of the United States of America. 106: 17910-5. PMID 19805192 DOI: 10.1073/Pnas.0909353106  0.761
2009 Wikenheiser J, Wolfram JA, Gargesha M, Yang K, Karunamuni G, Wilson DL, Semenza GL, Agani F, Fisher SA, Ward N, Watanabe M. Altered hypoxia-inducible factor-1 alpha expression levels correlate with coronary vessel anomalies. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 238: 2688-700. PMID 19777592 DOI: 10.1002/Dvdy.22089  0.471
2009 Siddiq A, Aminova LR, Troy CM, Suh K, Messer Z, Semenza GL, Ratan RR. Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 8828-38. PMID 19587290 DOI: 10.1523/Jneurosci.1779-09.2009  0.439
2009 Schipani E, Maes C, Carmeliet G, Semenza GL. Regulation of osteogenesis-angiogenesis coupling by HIFs and VEGF. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 24: 1347-53. PMID 19558314 DOI: 10.1359/Jbmr.090602  0.427
2009 Xia M, Huang R, Sun Y, Semenza GL, Aldred SF, Witt KL, Inglese J, Tice RR, Austin CP. Identification of chemical compounds that induce HIF-1alpha activity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 112: 153-63. PMID 19502547 DOI: 10.1093/Toxsci/Kfp123  0.526
2009 Semenza GL. Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis. Blood. 114: 2015-9. PMID 19494350 DOI: 10.1182/Blood-2009-05-189985  0.486
2009 Semenza G. Recent advances in vascular biology and their clinical relevance. Journal of Molecular Medicine (Berlin, Germany). 87: 547-8. PMID 19449144 DOI: 10.1007/S00109-009-0480-1  0.353
2009 Kizaka-Kondoh S, Itasaka S, Zeng L, Tanaka S, Zhao T, Takahashi Y, Shibuya K, Hirota K, Semenza GL, Hiraoka M. Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 3433-41. PMID 19417024 DOI: 10.1158/1078-0432.Ccr-08-2267  0.558
2009 Roman J, Rangasamy T, Guo J, Sugunan S, Meednu N, Packirisamy G, Shimoda LA, Golding A, Semenza G, Georas SN. T-cell activation under hypoxic conditions enhances IFN-gamma secretion. American Journal of Respiratory Cell and Molecular Biology. 42: 123-8. PMID 19372249 DOI: 10.1165/Rcmb.2008-0139Oc  0.437
2009 Semenza GL. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology (Bethesda, Md.). 24: 97-106. PMID 19364912 DOI: 10.1152/Physiol.00045.2008  0.53
2009 Lee K, Qian DZ, Rey S, Wei H, Liu JO, Semenza GL. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 2353-8. PMID 19168635 DOI: 10.1073/Pnas.0812801106  0.77
2009 Guo J, Lu W, Shimoda LA, Semenza GL, Georas SN. Enhanced interferon-gamma gene expression in T Cells and reduced ovalbumin-dependent lung eosinophilia in hypoxia-inducible factor-1-alpha-deficient mice. International Archives of Allergy and Immunology. 149: 98-102. PMID 19127065 DOI: 10.1159/000189191  0.5
2009 Semenza GL. Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells? Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 7969-70. PMID 19088010 DOI: 10.1158/1078-0432.Ccr-08-2417  0.549
2009 Ganten D, Semenza GL, Nolte C. Fostering trust-- Mol Med's scientific integrity policy. Journal of Molecular Medicine (Berlin, Germany). 87: 1-2. PMID 19066832 DOI: 10.1007/S00109-008-0428-X  0.323
2009 Yoon D, Okhotin D, Kim B, Okhotina Y, Okhotin DJ, Miasnikova GY, Sergueeva AI, Polyakova LA, Maslow A, Lee Y, Semenza GL, Prchal JT, Gordeuk VR. Increased Ratios of Internal Organ Volume to Body Mass in Chuvash Polycythemia and HIF-2α Repression of p21Cip Expression through C-MYC. Blood. 114: 5039-5039. DOI: 10.1182/Blood.V114.22.5039.5039  0.458
2009 Zhang H, Semenza GL. Reply to Lopez-Lazaro: Evidence that digoxin inhibits human cancer Proceedings of the National Academy of Sciences. 106: E27-E27. DOI: 10.1073/Pnas.0900125106  0.446
2009 Semenza G. 5 Hypoxia-inducible factor 1 in cancer pathogenesis and therapy European Journal of Cancer Supplements. 7: 4. DOI: 10.1016/S1359-6349(09)70012-6  0.422
2009 Xing D, Marti G, Liu L, Zhang X, Reinblatt M, Semenza GL, Harmon JW. Hypoxia colocalizes with increased levels of HIF-1 alpha and its angiogenic transcription products SDF-1 and VEGF in the burn wound Journal of the American College of Surgeons. 209: S74. DOI: 10.1016/J.Jamcollsurg.2009.06.179  0.458
2008 Semenza GL. Regulation of cancer cell metabolism by hypoxia-inducible factor 1. Seminars in Cancer Biology. 19: 12-6. PMID 19114105 DOI: 10.1016/J.Semcancer.2008.11.009  0.511
2008 Ratan RR, Siddiq A, Aminova L, Langley B, McConoughey S, Karpisheva K, Lee HH, Carmichael T, Kornblum H, Coppola G, Geschwind DH, Hoke A, Smirnova N, Rink C, Roy S, ... ... Semenza GL, et al. Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury. Annals of the New York Academy of Sciences. 1147: 383-94. PMID 19076458 DOI: 10.1196/Annals.1427.033  0.454
2008 Semenza GL. Tumor metabolism: cancer cells give and take lactate. The Journal of Clinical Investigation. 118: 3835-7. PMID 19033652 DOI: 10.1172/Jci37373  0.496
2008 Zhang H, Qian DZ, Tan YS, Lee K, Gao P, Ren YR, Rey S, Hammers H, Chang D, Pili R, Dang CV, Liu JO, Semenza GL. Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth Proceedings of the National Academy of Sciences of the United States of America. 105: 19579-19586. PMID 19020076 DOI: 10.1073/Pnas.0809763105  0.762
2008 Nanduri J, Yuan G, Kumar GK, Semenza GL, Prabhakar NR. Transcriptional responses to intermittent hypoxia. Respiratory Physiology & Neurobiology. 164: 277-81. PMID 18692603 DOI: 10.1016/J.Resp.2008.07.006  0.501
2008 Yuan G, Nanduri J, Khan S, Semenza GL, Prabhakar NR. Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR. Journal of Cellular Physiology. 217: 674-85. PMID 18651560 DOI: 10.1002/Jcp.21537  0.473
2008 Sullivan R, Paré GC, Frederiksen LJ, Semenza GL, Graham CH. Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity. Molecular Cancer Therapeutics. 7: 1961-73. PMID 18645006 DOI: 10.1158/1535-7163.Mct-08-0198  0.49
2008 Zhang H, Semenza GL. The expanding universe of hypoxia. Journal of Molecular Medicine (Berlin, Germany). 86: 739-46. PMID 18551266 DOI: 10.1007/S00109-008-0364-9  0.453
2008 Semenza GL. Hypoxia-inducible factor 1 and cancer pathogenesis. Iubmb Life. 60: 591-7. PMID 18506846 DOI: 10.1002/Iub.93  0.556
2008 Liu L, Marti GP, Wei X, Zhang X, Zhang H, Liu YV, Nastai M, Semenza GL, Harmon JW. Age-dependent impairment of HIF-1alpha expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells. Journal of Cellular Physiology. 217: 319-27. PMID 18506785 DOI: 10.1002/Jcp.21503  0.456
2008 Oda S, Oda T, Nishi K, Takabuchi S, Wakamatsu T, Tanaka T, Adachi T, Fukuda K, Semenza GL, Hirota K. Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner. Plos One. 3: e2215. PMID 18493321 DOI: 10.1371/Journal.Pone.0002215  0.567
2008 Semenza GL. A new weapon for attacking tumor blood vessels. The New England Journal of Medicine. 358: 2066-7. PMID 18463385 DOI: 10.1056/Nejmcibr0800272  0.416
2008 Semenza GL. O2 sensing: only skin deep? Cell. 133: 206-8. PMID 18423190 DOI: 10.1016/J.Cell.2008.04.004  0.407
2008 Semenza GL. Mitochondrial autophagy: life and breath of the cell. Autophagy. 4: 534-6. PMID 18376135 DOI: 10.4161/Auto.5956  0.461
2008 Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ, Semenza GL. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. The Journal of Biological Chemistry. 283: 10892-903. PMID 18281291 DOI: 10.1074/Jbc.M800102200  0.732
2008 Nishi K, Oda T, Takabuchi S, Oda S, Fukuda K, Adachi T, Semenza GL, Shingu K, Hirota K. LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner. Antioxidants & Redox Signaling. 10: 983-95. PMID 18199003 DOI: 10.1089/Ars.2007.1825  0.526
2008 Whitman EM, Pisarcik S, Luke T, Fallon M, Wang J, Sylvester JT, Semenza GL, Shimoda LA. Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes. American Journal of Physiology. Lung Cellular and Molecular Physiology. 294: L309-18. PMID 18065659 DOI: 10.1152/Ajplung.00091.2007  0.419
2008 Kimura M, Takabuchi S, Tanaka T, Murata M, Nishi K, Oda S, Oda T, Kanai M, Fukuda K, Kizaka-Kondoh S, Adachi T, Takabayashi A, Semenza GL, Hirota K. n-Propyl gallate activates hypoxia-inducible factor 1 by modulating intracellular oxygen-sensing systems. The Biochemical Journal. 411: 97-105. PMID 18047470 DOI: 10.1042/Bj20070824  0.538
2008 Cai Z, Zhong H, Bosch-Marce M, Fox-Talbot K, Wang L, Wei C, Trush MA, Semenza GL. Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha. Cardiovascular Research. 77: 463-70. PMID 18006459 DOI: 10.1093/Cvr/Cvm035  0.725
2008 Krishnamachary B, Semenza GL. Analysis of hypoxia-inducible factor 1alpha expression and its effects on invasion and metastasis. Methods in Enzymology. 435: 347-54. PMID 17998062 DOI: 10.1016/S0076-6879(07)35017-9  0.569
2008 Semenza GL. Vasculogenesis, angiogenesis, and arteriogenesis: mechanisms of blood vessel formation and remodeling. Journal of Cellular Biochemistry. 102: 840-7. PMID 17891779 DOI: 10.1002/JCB.21523  0.288
2008 Semenza GL. HIF-1 mediates the Warburg effect in clear cell renal carcinoma. Journal of Bioenergetics and Biomembranes. 39: 231-4. PMID 17551816 DOI: 10.1007/S10863-007-9081-2  0.525
2008 Ratan RR, Semenza G, Ryu H, Zaman K, Aminova L, Lee J, Kung A, Mwidau A. Transcriptional mechanisms of neuroprotection by iron chelators Journal of Neurochemistry. 81: 80-80. DOI: 10.1046/j.1471-4159.81.s1.102.x  0.246
2008 Semenza GL. Regulation of Ischemia-Induced Vascularization by Hypoxia-Inducible Factor 1 Journal of Molecular and Cellular Cardiology. 45: S7. DOI: 10.1016/J.Yjmcc.2008.09.613  0.499
2008 Zhang X, Wei X, Liu L, Marti G, Ghanamah M, Strom L, Spence R, Milner S, Semenza GL, Harmon JW. Increasing severity of thermal injury causes delayed mobilization of circulating angiogenic cells (CACs) and impaired perfusion in a murine burn wound model Journal of the American College of Surgeons. 207: S69-S70. DOI: 10.1016/J.Jamcollsurg.2008.06.173  0.353
2007 Semenza GL. Hypoxia and human disease-and the Journal of Molecular Medicine. Journal of Molecular Medicine (Berlin, Germany). 85: 1293-4. PMID 18026915 DOI: 10.1007/S00109-007-0285-Z  0.514
2007 Liu YV, Hubbi ME, Pan F, McDonald KR, Mansharamani M, Cole RN, Liu JO, Semenza GL. Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization. The Journal of Biological Chemistry. 282: 37064-73. PMID 17965024 DOI: 10.1074/Jbc.M705015200  0.762
2007 Semenza GL. Evaluation of HIF-1 inhibitors as anticancer agents. Drug Discovery Today. 12: 853-9. PMID 17933687 DOI: 10.1016/J.Drudis.2007.08.006  0.572
2007 Bosch-Marce M, Okuyama H, Wesley JB, Sarkar K, Kimura H, Liu YV, Zhang H, Strazza M, Rey S, Savino L, Zhou YF, McDonald KR, Na Y, Vandiver S, Rabi A, ... ... Semenza GL, et al. Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. Circulation Research. 101: 1310-8. PMID 17932327 DOI: 10.1161/Circresaha.107.153346  0.825
2007 Semenza GL. Hypoxia-inducible factor 1 (HIF-1) pathway. Science's Stke : Signal Transduction Knowledge Environment. 2007: cm8. PMID 17925579 DOI: 10.1126/Stke.4072007Cm8  0.497
2007 Semenza GL. Life with oxygen. Science (New York, N.Y.). 318: 62-4. PMID 17916722 DOI: 10.1126/Science.1147949  0.49
2007 Baek JH, Liu YV, McDonald KR, Wesley JB, Zhang H, Semenza GL. Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha. The Journal of Biological Chemistry. 282: 33358-66. PMID 17875644 DOI: 10.1074/Jbc.M705627200  0.466
2007 Tan M, Gu Q, He H, Pamarthy D, Semenza GL, Sun Y. SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation. Oncogene. 27: 1404-11. PMID 17828303 DOI: 10.1038/Sj.Onc.1210780  0.513
2007 Kim JW, Gao P, Liu YC, Semenza GL, Dang CV. Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1 Molecular and Cellular Biology. 27: 7381-7393. PMID 17785433 DOI: 10.1128/Mcb.00440-07  0.557
2007 Gao P, Zhang H, Dinavahi R, Li F, Xiang Y, Raman V, Bhujwalla ZM, Felsher DW, Cheng L, Pevsner J, Lee LA, Semenza GL, Dang CV. HIF-dependent antitumorigenic effect of antioxidants in vivo. Cancer Cell. 12: 230-8. PMID 17785204 DOI: 10.1016/J.Ccr.2007.08.004  0.454
2007 Semenza GL. Regulation of tissue perfusion in mammals by hypoxia-inducible factor 1. Experimental Physiology. 92: 988-91. PMID 17720748 DOI: 10.1113/Expphysiol.2006.036343  0.529
2007 Semenza GL, Prabhakar NR. HIF-1-dependent respiratory, cardiovascular, and redox responses to chronic intermittent hypoxia. Antioxidants & Redox Signaling. 9: 1391-6. PMID 17627473 DOI: 10.1089/Ars.2007.1691  0.489
2007 Prabhakar NR, Kumar GK, Nanduri J, Semenza GL. ROS signaling in systemic and cellular responses to chronic intermittent hypoxia. Antioxidants & Redox Signaling. 9: 1397-403. PMID 17627465 DOI: 10.1089/Ars.2007.1732  0.433
2007 Tomita M, Semenza GL, Michiels C, Matsuda T, Uchihara JN, Okudaira T, Tanaka Y, Taira N, Ohshiro K, Mori N. Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells. The Biochemical Journal. 406: 317-23. PMID 17576198 DOI: 10.1042/Bj20070286  0.514
2007 Baek JH, Liu YV, McDonald KR, Wesley JB, Hubbi ME, Byun H, Semenza GL. Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha. The Journal of Biological Chemistry. 282: 23572-80. PMID 17558023 DOI: 10.1074/Jbc.M703504200  0.769
2007 Semenza GL. Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1. The Biochemical Journal. 405: 1-9. PMID 17555402 DOI: 10.1042/Bj20070389  0.468
2007 Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller KI, Dang CV, Semenza GL. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell. 11: 407-20. PMID 17482131 DOI: 10.1016/J.Ccr.2007.04.001  0.497
2007 Fukuda R, Zhang H, Kim Jw, Shimoda L, Dang CV, Semenza G. HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells Cell. 129: 111-122. PMID 17418790 DOI: 10.1016/J.Cell.2007.01.047  0.377
2007 Semenza GL. Hypoxia and cancer. Cancer Metastasis Reviews. 26: 223-4. PMID 17404692 DOI: 10.1007/S10555-007-9058-Y  0.496
2007 Liu YV, Semenza GL. RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization. Cell Cycle (Georgetown, Tex.). 6: 656-9. PMID 17361105 DOI: 10.4161/cc.6.6.3981  0.366
2007 Liu YV, Baek JH, Zhang H, Diez R, Cole RN, Semenza GL. RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha. Molecular Cell. 25: 207-17. PMID 17244529 DOI: 10.1016/J.Molcel.2007.01.001  0.452
2007 Komatsu DE, Bosch-Marce M, Semenza GL, Hadjiargyrou M. Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1alpha deficiency. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 22: 366-74. PMID 17181398 DOI: 10.1359/Jbmr.061207  0.733
2007 Xu B, Doughman Y, Turakhia M, Jiang W, Landsettle CE, Agani FH, Semenza GL, Watanabe M, Yang YC. Partial rescue of defects in Cited2-deficient embryos by HIF-1alpha heterozygosity. Developmental Biology. 301: 130-40. PMID 17022961 DOI: 10.1016/J.Ydbio.2006.08.072  0.485
2007 Liu L, Zhang X, Marti G, Mohebi P, Brown S, Zhang H, Savino L, Miyashita T, Semenza G, Harmon J. Hypoxia-inducible factor-1 alpha deficiency correlates with impaired dermal wound healing in older diabetic mice Journal of the American College of Surgeons. 205: S41-S42. DOI: 10.1016/J.Jamcollsurg.2007.06.096  0.414
2007 Semenza GL. Biographical sketch—Gregg L. Semenza Cancer and Metastasis Reviews. 26: 221-221. DOI: 10.1007/S10555-007-9057-Z  0.288
2006 Tatum JL, Kelloff GJ, Gillies RJ, Arbeit JM, Brown JM, Chao KS, Chapman JD, Eckelman WC, Fyles AW, Giaccia AJ, Hill RP, Koch CJ, Krishna MC, Krohn KA, Lewis JS, ... ... Semenza GL, et al. Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. International Journal of Radiation Biology. 82: 699-757. PMID 17118889 DOI: 10.1080/09553000601002324  0.578
2006 Zhou YF, Bosch-Marce M, Okuyama H, Krishnamachary B, Kimura H, Zhang L, Huso DL, Semenza GL. Spontaneous transformation of cultured mouse bone marrow-derived stromal cells. Cancer Research. 66: 10849-54. PMID 17108121 DOI: 10.1158/0008-5472.Can-06-2146  0.714
2006 Cai Z, Semenza GL. Is 15-min ischemia too lethal to be an ischemic preconditioning stimulus? Circulation Research. 99: e86. PMID 17095727 DOI: 10.1161/01.Res.0000249066.23049.70  0.342
2006 Semenza GL. Baffled by bafilomycin: an anticancer agent that induces hypoxia-inducible factor-1alpha expression. Molecular Pharmacology. 70: 1841-3. PMID 17000862 DOI: 10.1124/Mol.106.031062  0.513
2006 Peng YJ, Yuan G, Ramakrishnan D, Sharma SD, Bosch-Marce M, Kumar GK, Semenza GL, Prabhakar NR. Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia. The Journal of Physiology. 577: 705-16. PMID 16973705 DOI: 10.1113/Jphysiol.2006.114033  0.742
2006 Semenza GL. Hypoxia pathway linked to kidney failure. Nature Medicine. 12: 996-7. PMID 16960569 DOI: 10.1038/Nm0906-996  0.488
2006 Yoon D, Pastore YD, Divoky V, Liu E, Mlodnicka AE, Rainey K, Ponka P, Semenza GL, Schumacher A, Prchal JT. Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. The Journal of Biological Chemistry. 281: 25703-11. PMID 16787915 DOI: 10.1074/Jbc.M602329200  0.467
2006 Shimoda LA, Fallon M, Pisarcik S, Wang J, Semenza GL. HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes. American Journal of Physiology. Lung Cellular and Molecular Physiology. 291: L941-9. PMID 16766575 DOI: 10.1152/Ajplung.00528.2005  0.471
2006 Semenza GL. Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia-inducible factor 1. Experimental Physiology. 91: 803-6. PMID 16740642 DOI: 10.1113/Expphysiol.2006.033498  0.522
2006 Hirota K, Semenza GL. Regulation of angiogenesis by hypoxia-inducible factor 1. Critical Reviews in Oncology/Hematology. 59: 15-26. PMID 16716598 DOI: 10.1016/J.Critrevonc.2005.12.003  0.557
2006 Semenza GL. VHL and p53: tumor suppressors team up to prevent cancer. Molecular Cell. 22: 437-9. PMID 16713574 DOI: 10.1016/J.Molcel.2006.05.001  0.44
2006 Wang J, Weigand L, Lu W, Sylvester JT, Semenza GL, Shimoda LA. Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells. Circulation Research. 98: 1528-37. PMID 16709899 DOI: 10.1161/01.Res.0000227551.68124.98  0.416
2006 Semenza GL. Therapeutic angiogenesis: another passing phase? Circulation Research. 98: 1115-6. PMID 16690890 DOI: 10.1161/01.Res.0000223485.43020.9E  0.446
2006 Semenza GL, Shimoda LA, Prabhakar NR. Regulation of gene expression by HIF-1. Novartis Foundation Symposium. 272: 2-8; discussion 8-14. PMID 16686426 DOI: 10.1002/9780470035009.Ch2  0.521
2006 Melillo G, Semenza GL. Meeting report: exploiting the tumor microenvironment for therapeutics. Cancer Research. 66: 4558-60. PMID 16651404 DOI: 10.1158/0008-5472.Can-06-0069  0.48
2006 Okuyama H, Krishnamachary B, Zhou YF, Nagasawa H, Bosch-Marce M, Semenza GL. Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1. The Journal of Biological Chemistry. 281: 15554-63. PMID 16574650 DOI: 10.1074/Jbc.M602003200  0.759
2006 Semenza GL. Development of novel therapeutic strategies that target HIF-1. Expert Opinion On Therapeutic Targets. 10: 267-80. PMID 16548775 DOI: 10.1517/14728222.10.2.267  0.559
2006 Kim JW, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia Cell Metabolism. 3: 177-185. PMID 16517405 DOI: 10.1016/J.Cmet.2006.02.002  0.472
2006 Krishnamachary B, Zagzag D, Nagasawa H, Rainey K, Okuyama H, Baek JH, Semenza GL. Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Research. 66: 2725-31. PMID 16510593 DOI: 10.1158/0008-5472.Can-05-3719  0.501
2006 Li J, Bosch-Marce M, Nanayakkara A, Savransky V, Fried SK, Semenza GL, Polotsky VY. Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1alpha. Physiological Genomics. 25: 450-7. PMID 16507783 DOI: 10.1152/Physiolgenomics.00293.2005  0.72
2006 Oda T, Hirota K, Nishi K, Takabuchi S, Oda S, Yamada H, Arai T, Fukuda K, Kita T, Adachi T, Semenza GL, Nohara R. Activation of hypoxia-inducible factor 1 during macrophage differentiation. American Journal of Physiology. Cell Physiology. 291: C104-13. PMID 16481368 DOI: 10.1152/Ajpcell.00614.2005  0.474
2006 Campochiaro PA, Alani R, Alitalo K, Brooks P, Caldwell R, Carmeliet P, Claudio PP, D'Amato R, Das A, De Martin R, Detmar M, Ferrara N, Frank RN, Fruttiger M, Giordano A, ... ... Semenza G, et al. Ocular versus extraocular neovascularization: Mirror images or vague resemblances Investigative Ophthalmology and Visual Science. 47: 462-474. PMID 16431938 DOI: 10.1167/Iovs.05-1494  0.297
2006 Semenza GL. Involvement of hypoxia-inducible factor 1 in pulmonary pathophysiology. Chest. 128: 592S-594S. PMID 16373853 DOI: 10.1378/Chest.128.6_Suppl.592S  0.498
2006 Semenza GL. New insights into nNOS regulation of vascular homeostasis. The Journal of Clinical Investigation. 115: 2976-8. PMID 16276412 DOI: 10.1172/Jci26792  0.462
2006 Lahiri S, Roy A, Baby SM, Hoshi T, Semenza GL, Prabhakar NR. Oxygen sensing in the body. Progress in Biophysics and Molecular Biology. 91: 249-86. PMID 16137743 DOI: 10.1016/J.Pbiomolbio.2005.07.001  0.447
2006 Semenza GL. EC does it with HIF Blood. 107: 419-420. DOI: 10.1182/Blood-2005-10-4263  0.49
2006 Watkins A, Abungu B, Sentil M, Lu Q, Barlos D, Prescott L, Caputo F, McCracken B, Xu D, Bosch-Marce M, Semenza G, Deitch E, Feinman R. PARTIAL HIF-1?? DEFICIENCY ATTENUATES ISCHEMIA REPERFUSION-MEDIATED GUT AND LUNG INJURY Shock. 25: 5-6. DOI: 10.1097/00024382-200606001-00016  0.67
2006 Zhou Y, Su Q, Kimura H, Okuyama H, Bosch-Marce M, Johns RA, Semenza GL. Increased expression of fractalkine and its receptor in mouse hind limb ischemic tissues and bone marrow-derives stem cells under hypoxic condition Vascular Pharmacology. 45: e26. DOI: 10.1016/J.Vph.2006.08.113  0.708
2005 Cai Z, Semenza GL. PTEN activity is modulated during ischemia and reperfusion: involvement in the induction and decay of preconditioning. Circulation Research. 97: 1351-9. PMID 16284183 DOI: 10.1161/01.Res.0000195656.52760.30  0.342
2005 Hirota K, Semenza GL. Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases. Biochemical and Biophysical Research Communications. 338: 610-6. PMID 16154531 DOI: 10.1016/J.Bbrc.2005.08.193  0.502
2005 Semenza GL. Pulmonary vascular responses to chronic hypoxia mediated by hypoxia-inducible factor 1. Proceedings of the American Thoracic Society. 2: 68-70. PMID 16113471 DOI: 10.1513/pats.200404-029MS  0.426
2005 Resar JR, Roguin A, Voner J, Nasir K, Hennebry TA, Miller JM, Ingersoll R, Kasch LM, Semenza GL. Hypoxia-inducible factor 1alpha polymorphism and coronary collaterals in patients with ischemic heart disease. Chest. 128: 787-91. PMID 16100168 DOI: 10.1378/Chest.128.2.787  0.441
2005 Maloyan A, Eli-Berchoer L, Semenza GL, Gerstenblith G, Stern MD, Horowitz M. HIF-1alpha-targeted pathways are activated by heat acclimation and contribute to acclimation-ischemic cross-tolerance in the heart. Physiological Genomics. 23: 79-88. PMID 16046617 DOI: 10.1152/Physiolgenomics.00279.2004  0.454
2005 Zagzag D, Krishnamachary B, Yee H, Okuyama H, Chiriboga L, Ali MA, Melamed J, Semenza GL. Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor. Cancer Research. 65: 6178-88. PMID 16024619 DOI: 10.1158/0008-5472.Can-04-4406  0.482
2005 Xu Q, Briggs J, Park S, Niu G, Kortylewski M, Zhang S, Gritsko T, Turkson J, Kay H, Semenza GL, Cheng JQ, Jove R, Yu H. Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways Oncogene. 24: 5552-5560. PMID 16007214 DOI: 10.1038/Sj.Onc.1208719  0.516
2005 Patel TH, Kimura H, Weiss CR, Semenza GL, Hofmann LV. Constitutively active HIF-1alpha improves perfusion and arterial remodeling in an endovascular model of limb ischemia. Cardiovascular Research. 68: 144-54. PMID 15921668 DOI: 10.1016/J.Cardiores.2005.05.002  0.417
2005 Greijer AE, van der Groep P, Kemming D, Shvarts A, Semenza GL, Meijer GA, van de Wiel MA, Belien JA, van Diest PJ, van der Wall E. Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1). The Journal of Pathology. 206: 291-304. PMID 15906272 DOI: 10.1002/Path.1778  0.52
2005 Gray MJ, Zhang J, Ellis LM, Semenza GL, Evans DB, Watowich SS, Gallick GE. HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene. 24: 3110-20. PMID 15735682 DOI: 10.1038/Sj.Onc.1208513  0.537
2005 Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL. OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha. Molecular Cell. 17: 503-12. PMID 15721254 DOI: 10.1016/J.Molcel.2005.01.011  0.489
2005 Yuan G, Nanduri J, Bhasker CR, Semenza GL, Prabhakar NR. Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia. The Journal of Biological Chemistry. 280: 4321-8. PMID 15569687 DOI: 10.1074/Jbc.M407706200  0.501
2005 Manalo DJ, Rowan A, Lavoie T, Natarajan L, Kelly BD, Ye SQ, Garcia JG, Semenza GL. Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood. 105: 659-69. PMID 15374877 DOI: 10.1182/Blood-2004-07-2958  0.548
2005 Dang CV, Semenza GL. Cancer energy metabolism Drug Discovery Today: Disease Mechanisms. 2. DOI: 10.1016/J.Ddmec.2005.05.039  0.39
2004 Takabuchi S, Hirota K, Nishi K, Oda S, Oda T, Shingu K, Takabayashi A, Adachi T, Semenza GL, Fukuda K. The intravenous anesthetic propofol inhibits hypoxia-inducible factor 1 activity in an oxygen tension-dependent manner. Febs Letters. 577: 434-8. PMID 15556623 DOI: 10.1016/J.Febslet.2004.10.042  0.54
2004 Takabuchi S, Hirota K, Nishi K, Oda S, Oda T, Shingu K, Takabayashi A, Adachi T, Semenza GL, Fukuda K. The inhibitory effect of sodium nitroprusside on HIF-1 activation is not dependent on nitric oxide-soluble guanylyl cyclase pathway. Biochemical and Biophysical Research Communications. 324: 417-23. PMID 15465035 DOI: 10.1016/J.Bbrc.2004.09.064  0.518
2004 Semenza GL. Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology (Bethesda, Md.). 19: 176-82. PMID 15304631 DOI: 10.1152/Physiol.00001.2004  0.474
2004 Hirota K, Fukuda R, Takabuchi S, Kizaka-Kondoh S, Adachi T, Fukuda K, Semenza GL. Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling. The Journal of Biological Chemistry. 279: 41521-8. PMID 15280370 DOI: 10.1074/Jbc.M405164200  0.504
2004 Stoeltzing O, McCarty MF, Wey JS, Fan F, Liu W, Belcheva A, Bucana CD, Semenza GL, Ellis LM. Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation. Journal of the National Cancer Institute. 96: 946-56. PMID 15199114 DOI: 10.1093/Jnci/Djh168  0.535
2004 Semenza GL. Intratumoral hypoxia, radiation resistance, and HIF-1. Cancer Cell. 5: 405-6. PMID 15144945 DOI: 10.1016/S1535-6108(04)00118-7  0.475
2004 Kaufman B, Scharf O, Arbeit J, Ashcroft M, Brown JM, Bruick RK, Chapman JD, Evans SM, Giaccia AJ, Harris AL, Huang E, Johnson R, Kaelin W, Koch CJ, Maxwell P, ... ... Semenza GL, et al. Proceedings of the Oxygen Homeostasis/Hypoxia Meeting. Cancer Research. 64: 3350-6. PMID 15126380 DOI: 10.1158/0008-5472.Can-03-2611  0.626
2004 Cai Z, Semenza GL. Phosphatidylinositol-3-kinase signaling is required for erythropoietin-mediated acute protection against myocardial ischemia/reperfusion injury. Circulation. 109: 2050-3. PMID 15117842 DOI: 10.1161/01.Cir.0000127954.98131.23  0.361
2004 Zhong H, Semenza GL, Simons JW, De Marzo AM. Up-regulation of hypoxia-inducible factor 1alpha is an early event in prostate carcinogenesis. Cancer Detection and Prevention. 28: 88-93. PMID 15068831 DOI: 10.1016/J.Cdp.2003.12.009  0.409
2004 Shimoda LA, Semenza GL. Functional analysis of the role of hypoxia-inducible factor 1 in the pathogenesis of hypoxic pulmonary hypertension. Methods in Enzymology. 381: 121-9. PMID 15063669 DOI: 10.1016/S0076-6879(04)81007-3  0.498
2004 Semenza GL. O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1. Journal of Applied Physiology (Bethesda, Md. : 1985). 96: 1173-7; discussion 1. PMID 14766767 DOI: 10.1152/Japplphysiol.00770.2003  0.508
2004 Kasuno K, Takabuchi S, Fukuda K, Kizaka-Kondoh S, Yodoi J, Adachi T, Semenza GL, Hirota K. Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling. The Journal of Biological Chemistry. 279: 2550-8. PMID 14600153 DOI: 10.1074/jbc.M308197200  0.44
2004 Stoeltzing O, McCarty MF, Wey J, Fan F, Liu W, Bucana CD, Mansfield P, Semenza GL, Ellis LM. Inhibition of HIF-1α reduces tumor growth and angiogenesis of human gastric cancer Annals of Surgical Oncology. 11. DOI: 10.1007/Bf02524012  0.459
2003 Kelly BD, Hackett SF, Hirota K, Oshima Y, Cai Z, Berg-Dixon S, Rowan A, Yan Z, Campochiaro PA, Semenza GL. Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circulation Research. 93: 1074-81. PMID 14576200 DOI: 10.1161/01.Res.0000102937.50486.1B  0.533
2003 Semenza GL. Targeting HIF-1 for cancer therapy. Nature Reviews. Cancer. 3: 721-32. PMID 13130303 DOI: 10.1038/Nrc1187  0.57
2003 Stoeltzing O, Liu W, Reinmuth N, Fan F, Parikh AA, Bucana CD, Evans DB, Semenza GL, Ellis LM. Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer. The American Journal of Pathology. 163: 1001-11. PMID 12937141 DOI: 10.1016/S0002-9440(10)63460-8  0.501
2003 Cai Z, Manalo DJ, Wei G, Rodriguez ER, Fox-Talbot K, Lu H, Zweier JL, Semenza GL. Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury. Circulation. 108: 79-85. PMID 12796124 DOI: 10.1161/01.Cir.0000078635.89229.8A  0.432
2003 Fukuda R, Kelly B, Semenza GL. Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1. Cancer Research. 63: 2330-4. PMID 12727858  0.464
2003 Bos R, van der Groep P, Greijer AE, Shvarts A, Meijer S, Pinedo HM, Semenza GL, van Diest PJ, van der Wall E. Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer. 97: 1573-81. PMID 12627523 DOI: 10.1002/cncr.11246  0.468
2003 Krishnamachary B, Berg-Dixon S, Kelly B, Agani F, Feldser D, Ferreira G, Iyer N, LaRusch J, Pak B, Taghavi P, Semenza GL. Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Research. 63: 1138-43. PMID 12615733  0.474
2003 Büchler P, Reber HA, Büchler M, Shrinkante S, Büchler MW, Friess H, Semenza GL, Hines OJ. Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer. Pancreas. 26: 56-64. PMID 12499918 DOI: 10.1097/00006676-200301000-00010  0.45
2003 Janssen HL, Haustermans KM, Sprong D, Blommestijn G, Hofland I, Hoebers FJ, Blijweert E, Raleigh JA, Semenza GL, Varia MA, Balm AJ, van Velthuysen ML, Delaere P, Sciot R, Begg AC. HIF-1A, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors. International Journal of Radiation Oncology, Biology, Physics. 54: 1537-49. PMID 12459383 DOI: 10.1016/S0360-3016(02)03935-4  0.397
2002 Ang SO, Chen H, Hirota K, Gordeuk VR, Jelinek J, Guan Y, Liu E, Sergueeva AI, Miasnikova GY, Mole D, Maxwell PH, Stockton DW, Semenza GL, Prchal JT. Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia Nature Genetics. 32: 614-621. PMID 12415268 DOI: 10.1038/Ng1019  0.447
2002 Semenza G. Signal transduction to hypoxia-inducible factor 1. Biochemical Pharmacology. 64: 993-8. PMID 12213597 DOI: 10.1016/S0006-2952(02)01168-1  0.517
2002 Semenza GL. Physiology meets biophysics: visualizing the interaction of hypoxia-inducible factor 1 alpha with p300 and CBP. Proceedings of the National Academy of Sciences of the United States of America. 99: 11570-2. PMID 12186981 DOI: 10.1073/Pnas.192442299  0.463
2002 Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM, Semenza GL. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. The Journal of Biological Chemistry. 277: 38205-11. PMID 12149254 DOI: 10.1074/Jbc.M203781200  0.521
2002 Treins C, Giorgetti-Peraldi S, Murdaca J, Semenza GL, Van Obberghen E. Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. The Journal of Biological Chemistry. 277: 27975-81. PMID 12032158 DOI: 10.1074/Jbc.M204152200  0.504
2002 Cargile CB, Goh DL, Goodman BK, Chen XN, Korenberg JR, Semenza GL, Thomas GH. Molecular cytogenetic characterization of a subtle interstitial del(3)(p25.3p26.2) in a patient with deletion 3p syndrome. American Journal of Medical Genetics. 109: 133-8. PMID 11977162 DOI: 10.1002/Ajmg.10323  0.322
2002 Semenza GL. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends in Molecular Medicine. 8: S62-7. PMID 11927290 DOI: 10.1016/S1471-4914(02)02317-1  0.567
2002 Semenza GL. Involvement of hypoxia-inducible factor 1 in human cancer. Internal Medicine (Tokyo, Japan). 41: 79-83. PMID 11868612 DOI: 10.2169/Internalmedicine.41.79  0.55
2002 Kojima H, Gu H, Nomura S, Caldwell CC, Kobata T, Carmeliet P, Semenza GL, Sitkovsky MV. Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 2170-4. PMID 11854513 DOI: 10.1073/Pnas.052706699  0.476
2002 Kline DD, Peng YJ, Manalo DJ, Semenza GL, Prabhakar NR. Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha. Proceedings of the National Academy of Sciences of the United States of America. 99: 821-6. PMID 11792862 DOI: 10.1073/Pnas.022634199  0.641
2002 Bos R, van Der Hoeven JJ, van Der Wall E, van Der Groep P, van Diest PJ, Comans EF, Joshi U, Semenza GL, Hoekstra OS, Lammertsma AA, Molthoff CF. Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 20: 379-87. PMID 11786564  0.407
2002 Itoh T, Namba T, Fukuda K, Semenza GL, Hirota K. Reversible inhibition of hypoxia-inducible factor 1 activation by exposure of hypoxic cells to the volatile anesthetic halothane. Febs Letters. 509: 225-9. PMID 11741593 DOI: 10.1016/S0014-5793(01)03119-2  0.552
2001 Semenza GL. Angiogenesis in ischemic and neoplastic disorders. Annual Review of Medicine. 54: 17-28. PMID 12359828 DOI: 10.1146/Annurev.Med.54.101601.152418  0.499
2001 Semenza GL, Artemov D, Bedi A, Bhujwalla Z, Chiles K, Feldser D, Laughner E, Ravi R, Simons J, Taghavi P, Zhong H. 'The metabolism of tumours': 70 years later Novartis Foundation Symposium. 240: 251-260. PMID 11727934 DOI: 10.1002/0470868716.Ch17  0.538
2001 Tuder RM, Chacon M, Alger L, Wang J, Taraseviciene-Stewart L, Kasahara Y, Cool CD, Bishop AE, Geraci M, Semenza GL, Yacoub M, Polak JM, Voelkel NF. Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis. The Journal of Pathology. 195: 367-74. PMID 11673836 DOI: 10.1002/Path.953  0.463
2001 Mahon PC, Hirota K, Semenza GL. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes & Development. 15: 2675-86. PMID 11641274 DOI: 10.1101/Gad.924501  0.498
2001 Semenza GL. HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell. 107: 1-3. PMID 11595178 DOI: 10.1016/S0092-8674(01)00518-9  0.491
2001 Semenza GL. Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends in Molecular Medicine. 7: 345-50. PMID 11516994 DOI: 10.1016/S1471-4914(01)02090-1  0.545
2001 Semenza GL. Regulation of hypoxia-induced angiogenesis: a chaperone escorts VEGF to the dance. The Journal of Clinical Investigation. 108: 39-40. PMID 11435455 DOI: 10.1172/Jci13374  0.534
2001 Shimoda LA, Manalo DJ, Sham JS, Semenza GL, Sylvester JT. Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia. American Journal of Physiology. Lung Cellular and Molecular Physiology. 281: L202-8. PMID 11404263 DOI: 10.1152/Ajplung.2001.281.1.L202  0.432
2001 Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Molecular and Cellular Biology. 21: 3995-4004. PMID 11359907 DOI: 10.1128/Mcb.21.12.3995-4004.2001  0.55
2001 Semenza GL. Hypoxia-inducible factor 1: control of oxygen homeostasis in health and disease. Pediatric Research. 49: 614-7. PMID 11328942 DOI: 10.1203/00006450-200105000-00002  0.561
2001 Hirota K, Semenza GL. Rac1 activity is required for the activation of hypoxia-inducible factor 1. The Journal of Biological Chemistry. 276: 21166-72. PMID 11283021 DOI: 10.1074/Jbc.M100677200  0.534
2001 Dong Z, Venkatachalam MA, Wang J, Patel Y, Saikumar P, Semenza GL, Force T, Nishiyama J. Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms. The Journal of Biological Chemistry. 276: 18702-9. PMID 11278985 DOI: 10.1074/Jbc.M011774200  0.549
2001 Semenza GL. HIF-1 and mechanisms of hypoxia sensing. Current Opinion in Cell Biology. 13: 167-71. PMID 11248550 DOI: 10.1016/S0955-0674(00)00194-0  0.506
2001 Semenza GL. HIF-1: using two hands to flip the angiogenic switch. Cancer Metastasis Reviews. 19: 59-65. PMID 11191064 DOI: 10.1023/A:1026544214667  0.555
2001 Bos R, Zhong H, Hanrahan CF, Mommers EC, Semenza GL, Pinedo HM, Abeloff MD, Simons JW, van Diest PJ, van der Wall E. Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis. Journal of the National Cancer Institute. 93: 309-14. PMID 11181778 DOI: 10.1093/Jnci/93.4.309  0.554
2001 Gardner LB, Li Q, Park MS, Flanagan WM, Semenza GL, Dang CV. Hypoxia Inhibits G1/S Transition through Regulation of p27 Expression Journal of Biological Chemistry. 276: 7919-7926. PMID 11112789 DOI: 10.1074/Jbc.M010189200  0.481
2001 Maloyan A, Semenza G, Gerstenblith G, Stern M, Horowitz M. Heat-acclimation-ischemia cross-tolerance: Does HIF-1α play a role? Journal of Molecular and Cellular Cardiology. 33: A72. DOI: 10.1016/S0022-2828(01)90285-8  0.384
2000 Semenza GL. Oxygen-regulated transcription factors and their role in pulmonary disease. Respiratory Research. 1: 159-62. PMID 11667980 DOI: 10.1186/Rr27  0.46
2000 Zagzag D, Friedlander DR, Margolis B, Grumet M, Semenza GL, Zhong H, Simons JW, Holash J, Wiegand SJ, Yancopoulos GD. Molecular events implicated in brain tumor angiogenesis and invasion. Pediatric Neurosurgery. 33: 49-55. PMID 11025423 DOI: 10.1159/000028975  0.465
2000 Semenza GL. Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1. The Journal of Clinical Investigation. 106: 809-12. PMID 11018065 DOI: 10.1172/Jci11223  0.485
2000 Bergeron M, Gidday JM, Yu AY, Semenza GL, Ferriero DM, Sharp FR. Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain. Annals of Neurology. 48: 285-96. PMID 10976634 DOI: 10.1002/1531-8249(200009)48:3<285::Aid-Ana2>3.0.Co;2-8  0.498
2000 Semenza GL. Series Introduction: Tissue ischemia: pathophysiology and therapeutics Journal of Clinical Investigation. 106: 613-614. PMID 10974010 DOI: 10.1172/Jci10913  0.435
2000 Rivard A, Berthou-Soulie L, Principe N, Kearney M, Curry C, Branellec D, Semenza GL, Isner JM. Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity. The Journal of Biological Chemistry. 275: 29643-7. PMID 10882714 DOI: 10.1074/Jbc.M001029200  0.509
2000 Zagzag D, Zhong H, Scalzitti JM, Laughner E, Simons JW, Semenza GL. Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. Cancer. 88: 2606-18. PMID 10861440 DOI: 10.1002/1097-0142(20000601)88:11<2606::AID-CNCR25>3.0.CO;2-W  0.397
2000 Semenza GL. Chairman's summary: mechanisms of oxygen homeostasis, circa 1999. Advances in Experimental Medicine and Biology. 475: 303-10. PMID 10849671 DOI: 10.1007/0-306-46825-5_29  0.42
2000 Semenza GL, Agani F, Feldser D, Iyer N, Kotch L, Laughner E, Yu A. Hypoxia, HIF-1, and the pathophysiology of common human diseases Advances in Experimental Medicine and Biology. 475: 123-130. PMID 10849654  0.427
2000 Semenza GL. Hypoxia, clonal selection, and the role of HIF-1 in tumor progression. Critical Reviews in Biochemistry and Molecular Biology. 35: 71-103. PMID 10821478 DOI: 10.1080/10409230091169186  0.53
2000 Sutter CH, Laughner E, Semenza GL. Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations. Proceedings of the National Academy of Sciences of the United States of America. 97: 4748-53. PMID 10758161 DOI: 10.1073/Pnas.080072497  0.499
2000 Semenza GL. HIF-1: mediator of physiological and pathophysiological responses to hypoxia. Journal of Applied Physiology (Bethesda, Md. : 1985). 88: 1474-80. PMID 10749844 DOI: 10.1152/Jappl.2000.88.4.1474  0.501
2000 Becker PM, Alcasabas A, Yu AY, Semenza GL, Bunton TE. Oxygen-independent upregulation of vascular endothelial growth factor and vascular barrier dysfunction during ventilated pulmonary ischemia in isolated ferret lungs. American Journal of Respiratory Cell and Molecular Biology. 22: 272-9. PMID 10696063 DOI: 10.1165/Ajrcmb.22.3.3814  0.462
2000 Semenza GL. Cellular and molecular dissection of reperfusion injury: ROS within and without. Circulation Research. 86: 117-8. PMID 10666403 DOI: 10.1161/01.Res.86.2.117  0.429
2000 Semenza GL. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annual Review of Cell and Developmental Biology. 15: 551-78. PMID 10611972 DOI: 10.1146/Annurev.Cellbio.15.1.551  0.534
2000 Semenza GL. Expression of hypoxia-inducible factor 1: mechanisms and consequences. Biochemical Pharmacology. 59: 47-53. PMID 10605934 DOI: 10.1016/S0006-2952(99)00292-0  0.567
2000 Semenza GL. HIF-1 and human disease: one highly involved factor Genes & Development. 14: 1983-1991. DOI: 10.1101/Gad.14.16.1983  0.432
2000 Ravi R, Mookerjee B, Bhujwalla ZM, Sutter CH, Artemov D, Zeng Q, Dillehay LE, Madan A, Semenza GL, Bedi A. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α Genes & Development. 14: 34-44. DOI: 10.1101/Gad.14.1.34  0.542
1999 Bergeron M, Yu AY, Solway KE, Semenza GL, Sharp FR. Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain. The European Journal of Neuroscience. 11: 4159-70. PMID 10594641 DOI: 10.1046/J.1460-9568.1999.00845.X  0.508
1999 Zaman K, Ryu H, Hall D, O'Donovan K, Lin KI, Miller MP, Marquis JC, Baraban JM, Semenza GL, Ratan RR. Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 9821-30. PMID 10559391 DOI: 10.1523/Jneurosci.19-22-09821.1999  0.445
1999 Semenza GL. Perspectives on oxygen sensing. Cell. 98: 281-4. PMID 10458603 DOI: 10.1016/S0092-8674(00)81957-1  0.433
1999 Yu A, Alcasabas A, Semenza G, Becker P. Differential regulation of vascular endothelial growth factor during ventilated pulmonary ischemia. Chest. 116: 32S. PMID 10424577 DOI: 10.1378/Chest.116.Suppl_1.32S  0.441
1999 Semenza GL, Agani F, Iyer N, Kotch L, Laughner E, Leung S, Yu A. Regulation of cardiovascular development and physiology by hypoxia-inducible factor 1. Annals of the New York Academy of Sciences. 874: 262-8. PMID 10415537 DOI: 10.1111/J.1749-6632.1999.Tb09241.X  0.538
1999 Kotch LE, Iyer NV, Laughner E, Semenza GL. Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Developmental Biology. 209: 254-67. PMID 10328919 DOI: 10.1006/Dbio.1999.9253  0.492
1999 Dang CV, Semenza GL. Oncogenic alterations of metabolism Trends in Biochemical Sciences. 24: 68-72. PMID 10098401 DOI: 10.1016/S0968-0004(98)01344-9  0.447
1999 Yu AY, Shimoda LA, Iyer NV, Huso DL, Sun X, McWilliams R, Beaty T, Sham JS, Wiener CM, Sylvester JT, Semenza GL. Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha. The Journal of Clinical Investigation. 103: 691-6. PMID 10074486 DOI: 10.1172/Jci5912  0.498
1999 Zaman K, Ryu H, Hall D, O'Donovan K, Lin K, Miller MP, Marquis JC, Baraban JM, Semenza GL, Ratan RR. Protection from Oxidative Stress–Induced Apoptosis in Cortical Neuronal Cultures by Iron Chelators Is Associated with Enhanced DNA Binding of Hypoxia-Inducible Factor-1 and ATF-1/CREB and Increased Expression of Glycolytic Enzymes, p21waf1/cip1, and Erythropoietin The Journal of Neuroscience. 19: 9821-9830. DOI: 10.1523/JNEUROSCI.19-22-09821.1999  0.312
1998 Palmer LA, Semenza GL, Stoler MH, Johns RA. Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1. American Journal of Physiology. Lung Cellular and Molecular Physiology. 274: L212-L219. PMID 29585685 DOI: 10.1152/ajplung.1998.274.2.L212  0.42
1998 Yu AY, Frid MG, Shimoda LA, Wiener CM, Stenmark K, Semenza GL. Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung. American Journal of Physiology. Lung Cellular and Molecular Physiology. 275: L818-L826. PMID 29585640 DOI: 10.1152/ajplung.1998.275.4.L818  0.435
1998 Agani F, Semenza GL. Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity. Molecular Pharmacology. 54: 749-54. PMID 9804609 DOI: 10.1124/Mol.54.5.749  0.546
1998 Semenza GL. Hypoxia-inducible factor 1: master regulator of O2 homeostasis. Current Opinion in Genetics & Development. 8: 588-94. PMID 9794818 DOI: 10.1016/S0959-437X(98)80016-6  0.504
1998 Iyer NV, Leung SW, Semenza GL. The human hypoxia-inducible factor 1α gene: HIF1A structure and evolutionary conservation Genomics. 52: 159-165. PMID 9782081 DOI: 10.1006/Geno.1998.5416  0.457
1998 Yu AY, Frid MG, Shimoda LA, Wiener CM, Stenmark K, Semenza GL. Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung. The American Journal of Physiology. 275: L818-26. PMID 9755115 DOI: 10.1152/Ajplung.1998.275.4.L818  0.516
1998 Semenza GL, Agani F, Iyer N, Jiang BH, Leung S, Wiener C, Yu A. Hypoxia-inducible factor 1: from molecular biology to cardiopulmonary physiology. Chest. 114: 40S-45S. PMID 9676622 DOI: 10.1378/Chest.114.1_Supplement.40S  0.467
1998 Liu Y, Christou H, Morita T, Laughner E, Semenza GL, Kourembanas S. Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5' enhancer. The Journal of Biological Chemistry. 273: 15257-62. PMID 9614141 DOI: 10.1074/Jbc.273.24.15257  0.506
1998 Martin C, Yu AY, Jiang BH, Davis L, Kimberly D, Hohimer AR, Semenza GL. Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1. American Journal of Obstetrics and Gynecology. 178: 527-34. PMID 9539521 DOI: 10.1016/S0002-9378(98)70433-8  0.475
1998 Semenza GL. Hypoxia-inducible factor 1 and the molecular physiology of oxygen homeostasis. The Journal of Laboratory and Clinical Medicine. 131: 207-14. PMID 9523843 DOI: 10.1016/S0022-2143(98)90091-9  0.467
1998 Palmer LA, Semenza GL, Stoler MH, Johns RA. Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1. The American Journal of Physiology. 274: L212-9. PMID 9486205 DOI: 10.1152/Ajplung.1998.274.2.L212  0.403
1998 Iyer NV, Kotch LE, Agani F, Leung SW, Laughner E, Wenger RH, Gassmann M, Gearhart JD, Lawler AM, Yu AY, Semenza GL. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes & Development. 12: 149-62. PMID 9436976 DOI: 10.1101/Gad.12.2.149  0.531
1998 Semenza G, Leung S, Agani F, Iyer N, Kotch L, Laughner E, Yu A. Hypoxia-inducible factor 1α: Essential role in cardiovascular development and physiology Pathophysiology. 5: 28. DOI: 10.1016/S0928-4680(98)80385-4  0.469
1998 Semenza GL, Agani F, Iyer N, Jiang B, Laughner E, Leung S, Roe R, Wiener C, Yu A. Transcriptional Responses Mediated by Hypoxia-Inducible Factor 1 The Keio Journal of Medicine. 45: 421-427. DOI: 10.1007/978-4-431-68476-3_52  0.546
1997 Wang GL, Semenza GL. Molecular basis of hypoxia-induced erythropoietin expression. Current Opinion in Hematology. 3: 156-62. PMID 9372067 DOI: 10.1097/00062752-199603020-00009  0.507
1997 Jiang BH, Zheng JZ, Leung SW, Roe R, Semenza GL. Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension. The Journal of Biological Chemistry. 272: 19253-60. PMID 9235919 DOI: 10.1074/Jbc.272.31.19253  0.497
1997 Winograd J, Reilly MP, Roe R, Lutz J, Laughner E, Xu X, Hu L, Asakura T, vander Kolk C, Strandberg JD, Semenza GL. Perinatal lethality and multiple craniofacial malformations in MSX2 transgenic mice. Human Molecular Genetics. 6: 369-79. PMID 9147639 DOI: 10.1093/Hmg/6.3.369  0.411
1997 Doheny KF, Rasmussen SA, Rutberg J, Semenza GL, Stamberg J, Schwartz M, Batista DA, Stetten G, Thomas GH. Segregation of a familial balanced (12;10) insertion resulting in Dup(10)(q21.2q22.1) and Del(10)(q21.2q22.1) in first cousins. American Journal of Medical Genetics. 69: 188-93. PMID 9056559 DOI: 10.1002/(Sici)1096-8628(19970317)69:2<188::Aid-Ajmg14>3.0.Co;2-H  0.293
1997 Lee PJ, Jiang BH, Chin BY, Iyer NV, Alam J, Semenza GL, Choi AMK. Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia Journal of Biological Chemistry. 272: 5375-5381. PMID 9038135 DOI: 10.1074/Jbc.272.9.5375  0.538
1997 Semenza GL, Agani F, Booth G, Forsythe J, Iyer N, Jiang BH, Leung S, Roe R, Wiener C, Yu A. Structural and functional analysis of hypoxia-inducible factor 1. Kidney International. 51: 553-5. PMID 9027737 DOI: 10.1038/Ki.1997.77  0.516
1997 Semenza GL, Jiang BH, Leung SW, Passantino R, Concordet JP, Maire P, Giallongo A. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. The Journal of Biological Chemistry. 271: 32529-37. PMID 8955077 DOI: 10.1074/Jbc.271.51.32529  0.516
1996 Jiang BH, Semenza GL, Bauer C, Marti HH. Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. The American Journal of Physiology. 271: C1172-80. PMID 8897823 DOI: 10.1152/Ajpcell.1996.271.4.C1172  0.477
1996 Semenza GL, Rue EA, Iyer NV, Pang MG, Kearns WG. Assignment of the hypoxia-inducible factor 1alpha gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q. Genomics. 34: 437-9. PMID 8786149 DOI: 10.1006/Geno.1996.0311  0.384
1996 Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, Semenza GL. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Molecular and Cellular Biology. 16: 4604-13. PMID 8756616 DOI: 10.1128/Mcb.16.9.4604  0.55
1996 Wiener CM, Booth G, Semenza GL. In vivo expression of mRNAs encoding hypoxia-inducible factor 1. Biochemical and Biophysical Research Communications. 225: 485-8. PMID 8753788 DOI: 10.1006/Bbrc.1996.1199  0.514
1996 Jiang BH, Rue E, Wang GL, Roe R, Semenza GL. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. The Journal of Biological Chemistry. 271: 17771-8. PMID 8663540 DOI: 10.1074/Jbc.271.30.17771  0.474
1995 Wang GL, Semenza GL. Purification and characterization of hypoxia-inducible factor 1. The Journal of Biological Chemistry. 270: 1230-7. PMID 7836384 DOI: 10.1074/Jbc.270.3.1230  0.522
1995 Semenza GL, Wang GL, Kundu R. DNA Binding and Transcriptional Properties of Wild-Type and Mutant Forms of the Homeodomain Protein Msx2 Biochemical and Biophysical Research Communications. 209: 257-262. PMID 7726844 DOI: 10.1006/Bbrc.1995.1497  0.384
1995 Wang GL, Jiang BH, Semenza GL. Effect of altered redox states on expression and DNA-binding activity of hypoxia-inducible factor 1. Biochemical and Biophysical Research Communications. 212: 550-6. PMID 7626069 DOI: 10.1006/Bbrc.1995.2005  0.511
1995 Prchal JT, Semenza GL, Prchal J, Sokol L. Familial polycythemia. Science (New York, N.Y.). 268: 1831-2. PMID 7604250 DOI: 10.1126/science.7604250  0.176
1995 Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proceedings of the National Academy of Sciences of the United States of America. 92: 5510-4. PMID 7539918 DOI: 10.1073/Pnas.92.12.5510  0.508
1995 Wang GL, Jiang BH, Semenza GL. Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1. Biochemical and Biophysical Research Communications. 216: 669-75. PMID 7488163 DOI: 10.1006/Bbrc.1995.2674  0.494
1995 Sokol L, Luhovy M, Guan Y, Prchal J, Semenza G, Prchal J. Primary familial polycythemia: a frameshift mutation in the erythropoietin receptor gene and increased sensitivity of erythroid progenitors to erythropoietin Blood. 86: 15-22. DOI: 10.1182/blood.V86.1.15.bloodjournal86115  0.286
1994 Semenza GL. Erythropoietin gene expression in transgenic mice and human hepatoma cells. Annals of the New York Academy of Sciences. 718: 41-7; discussion 47-. PMID 8185250 DOI: 10.1111/J.1749-6632.1994.Tb55702.X  0.406
1994 Semenza GL. Transcriptional regulation of gene expression: mechanisms and pathophysiology. Human Mutation. 3: 180-99. PMID 8019554 DOI: 10.1002/Humu.1380030304  0.443
1994 Semenza GL. Regulation of Erythropoietin Production: New Insights Into Molecular Mechanisms of Oxygen Homeostasis Hematology/Oncology Clinics of North America. 8: 863-884. DOI: 10.1016/S0889-8588(18)30134-5  0.48
1993 Wang GL, Semenza GL. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proceedings of the National Academy of Sciences of the United States of America. 90: 4304-8. PMID 8387214 DOI: 10.1073/Pnas.90.9.4304  0.514
1993 Koury ST, Bondurant MC, Semenza GL, Koury MJ. The use of in situ hybridization to study erythropoietin gene expression in murine kidney and liver Microscopy Research and Technique. 25: 29-39. PMID 8353306 DOI: 10.1002/Jemt.1070250106  0.415
1993 Wang G, Semenza G. Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction Blood. 82: 3610-3615. DOI: 10.1182/Blood.V82.12.3610.Bloodjournal82123610  0.551
1992 Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Molecular and Cellular Biology. 12: 5447-54. PMID 1448077 DOI: 10.1128/Mcb.12.12.5447  0.498
1991 Semenza GL, Nejfelt MK, Chi SM, Antonarakis SE. Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene. Proceedings of the National Academy of Sciences of the United States of America. 88: 5680-4. PMID 2062846 DOI: 10.1073/Pnas.88.13.5680  0.652
1991 Semenza GL, Koury ST, Nejfelt MK, Gearhart JD, Antonarakis SE. Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 88: 8725-9. PMID 1924331 DOI: 10.1073/Pnas.88.19.8725  0.651
1991 Koury S, Bondurant M, Koury M, Semenza G. Localization of cells producing erythropoietin in murine liver by in situ hybridization [see comments] Blood. 77: 2497-2503. DOI: 10.1182/Blood.V77.11.2497.Bloodjournal77112497  0.389
1991 Koury S, Bondurant M, Koury M, Semenza G. Localization of cells producing erythropoietin in murine liver by in situ hybridization [see comments] Blood. 77: 2497-2503. DOI: 10.1182/blood.v77.11.2497.2497  0.288
1990 Semenza GL, Dureza RC, Traystman MD, Gearhart JD, Antonarakis SE. Human erythropoietin gene expression in transgenic mice: multiple transcription initiation sites and cis-acting regulatory elements. Molecular and Cellular Biology. 10: 930-8. PMID 2304468 DOI: 10.1128/mcb.10.3.930-938.1990  0.617
1989 Semenza GL, Traystman MD, Gearhart JD, Antonarakis SE. Polycythemia in transgenic mice expressing the human erythropoietin gene. Proceedings of the National Academy of Sciences of the United States of America. 86: 2301-5. PMID 2928334 DOI: 10.1073/Pnas.86.7.2301  0.601
1989 Semenza GL, Dowling CE, Kazazian HH. Hinf I polymorphism 3' to the human beta-globin gene detected by the polymerase chain reaction (PCR). Nucleic Acids Research. 17: 2376. PMID 2565032 DOI: 10.1093/Nar/17.6.2376  0.612
1988 Semenza GL, Pyeritz RE. Respiratory complications of mucopolysaccharide storage disorders. Medicine. 67: 209-19. PMID 3134589 DOI: 10.1097/00005792-198807000-00002  0.343
1987 Semenza GL, Ladias JA, Antonarakis SE. An Xba I polymorphism 3' to the human erythropoietin (EPO) gene. Nucleic Acids Research. 15: 6768. PMID 2888094 DOI: 10.1093/Nar/15.16.6768  0.572
1984 Semenza GL, Malladi P, Surrey S, Delgrosso K, Poncz M, Schwartz E. Detection of a novel DNA polymorphism in the beta-globin gene cluster. The Journal of Biological Chemistry. 259: 6045-8. PMID 6327661  0.652
1984 Semenza GL, Delgrosso K, Poncz M, Malladi P, Schwartz E, Surrey S. The silent carrier allele: beta thalassemia without a mutation in the beta-globin gene or its immediate flanking regions. Cell. 39: 123-8. PMID 6091904 DOI: 10.1016/0092-8674(84)90197-1  0.76
1984 Semenza GL, Delgrosso K, Surrey S, Malladi P, Schwartz E, Ponca M. THE SILENT CARRIER ALLELE: β-THALASSEMIA WITHOUT A MUTATION IN THE β-GLOBIN GENE REGION Pediatric Research. 18: 248A-248A. DOI: 10.1203/00006450-198404001-00931  0.779
1984 Semenza GL, Malladi P, Poncz M, Delgrosso K, Schwartz E, Surrey S. DETECTION OF A NOVEL DNA POLYMORPHISM IN THE β-GLOBIN CLUSTER AND EVIDENCE FOR SITE-SPECIFIC RECOMBINATION Pediatric Research. 18: 225A-225A. DOI: 10.1203/00006450-198404001-00794  0.765
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