| Year | Citation | Score | |||
|---|---|---|---|---|---|
| 2022 | Ascenção K, Dilek N, Zuhra K, Módis K, Sato T, Szabo C. Sequential Accumulation of 'Driver' Pathway Mutations Induces the Upregulation of Hydrogen-Sulfide-Producing Enzymes in Human Colonic Epithelial Cell Organoids. Antioxidants (Basel, Switzerland). 11. PMID 36139896 DOI: 10.3390/antiox11091823 | 0.618 | |||
| 2022 | Thanki KK, Johnson P, Higgins EJ, Maskey M, Phillips C, Dash S, Almenas FA, Govar AA, Tian B, Villéger R, Beswick E, Wang R, Szabo C, Chao C, Pinchuk IV, et al. Deletion of cystathionine-γ-lyase in bone marrow-derived cells promotes colitis-associated carcinogenesis. Redox Biology. 55: 102417. PMID 35933902 DOI: 10.1016/j.redox.2022.102417 | 0.643 | |||
| 2021 | Hellmich MR, Chao C, Módis K, Ding Y, Zatarain JR, Thanki K, Maskey M, Druzhyna N, Untereiner AA, Ahmad A, Xue Y, Chen H, Russell WK, Wang J, Zhou J, ... Szabo C, et al. Efficacy of Novel Aminooxyacetic Acid Prodrugs in Colon Cancer Models: Towards Clinical Translation of the Cystathionine β-Synthase Inhibition Concept. Biomolecules. 11. PMID 34439739 DOI: 10.3390/biom11081073 | 0.634 | |||
| 2020 | Lopez E, Fukuda S, Modis K, Fujiwara O, Enkhtaivan B, Trujillo-Abarca R, Ihara K, Lima-Lopez F, Perez-Bello D, Szabo C, Prough DS, Enkhbaatar P. ARGININE VASOPRESSIN RECEPTOR 2 ACTIVATION PROMOTES MICROVASCULAR PERMEABILITY IN SEPSIS. Pharmacological Research. 105272. PMID 33160069 DOI: 10.1016/j.phrs.2020.105272 | 0.632 | |||
| 2020 | Curtin NJ, Szabo C. Poly(ADP-ribose) polymerase inhibition: past, present and future. Nature Reviews. Drug Discovery. PMID 32884152 DOI: 10.1038/S41573-020-0076-6 | 0.321 | |||
| 2020 | Dilek N, Papapetropoulos A, Toliver-Kinsky T, Szabo C. Hydrogen sulfide: an endogenous regulator of the immune system. Pharmacological Research. 105119. PMID 32781284 DOI: 10.1016/J.Phrs.2020.105119 | 0.343 | |||
| 2020 | Szabo C, Martins V, Liaudet L. Poly(ADP-ribose) Polymerase Inhibition in Acute Lung Injury: A Re-emerging Concept. American Journal of Respiratory Cell and Molecular Biology. PMID 32640172 DOI: 10.1165/Rcmb.2020-0188Tr | 0.327 | |||
| 2020 | Gallyas F, Sumegi B, Szabo C. Role of Akt Activation in PARP Inhibitor Resistance in Cancer. Cancers. 12. PMID 32106627 DOI: 10.3390/Cancers12030532 | 0.319 | |||
| 2020 | Szabo C. The re-emerging pathophysiological role of the cystathionine-β-synthase - hydrogen sulfide system in Down syndrome. The Febs Journal. PMID 31955501 DOI: 10.1111/Febs.15214 | 0.365 | |||
| 2020 | Randi EB, Vervaet B, Tsachaki M, Porto E, Vermeylen S, Lindenmeyer MT, Thuy LTT, Cohen C, Devuyst O, Kistler AD, Szabo C, Kawada N, Hankeln T, Odermatt A, Dewilde S, et al. The anti-oxidative role of cytoglobin in podocytes: implications for a role in chronic kidney disease. Antioxidants & Redox Signaling. PMID 31910047 DOI: 10.1089/Ars.2019.7868 | 0.316 | |||
| 2019 | Panagaki T, Randi EB, Augsburger F, Szabo C. Overproduction of HS, generated by CBS, inhibits mitochondrial Complex IV and suppresses oxidative phosphorylation in Down syndrome. Proceedings of the National Academy of Sciences of the United States of America. PMID 31481613 DOI: 10.1073/Pnas.1911895116 | 0.337 | |||
| 2019 | Móodis K, Ramanujam VMS, Govar AA, Lopez E, Anderson KE, Wang R, Szabo C. Cystathionine-γ-lyase (CSE) deficiency increases erythropoiesis and promotes mitochondrial electron transport via the upregulation of coproporphyrinogen III oxidase and consequent stimulation of heme biosynthesis. Biochemical Pharmacology. PMID 31421132 DOI: 10.1016/J.Bcp.2019.08.006 | 0.33 | |||
| 2019 | Ahmad A, Haas De Mello A, Szczesny B, Törö G, Marcatti M, Druzhyna N, Liaudet L, Tarantini S, Salomao R, Garcia Soriano F, Szabo C. Effects of The Poly(ADP-ribose) Polymerase Inhibitor Olaparib in Cerulein-Induced Pancreatitis. Shock (Augusta, Ga.). PMID 31274831 DOI: 10.1097/Shk.0000000000001402 | 0.345 | |||
| 2019 | Ahmad A, Vieira JC, de Mello AH, de Lima TM, Ariga SK, Barbeiro DF, Barbeiro HV, Szczesny B, Törö G, Druzhyna N, Randi EB, Marcatti M, Toliver-Kinsky T, Kiss A, Liaudet L, ... ... Szabo C, et al. The PARP inhibitor olaparib exerts beneficial effects in mice subjected to cecal ligature and puncture and in cells subjected to oxidative stress without impairing DNA integrity: A potential opportunity for repurposing a clinically used oncological drug for the experimental therapy of sepsis. Pharmacological Research. 104263. PMID 31071432 DOI: 10.1016/J.Phrs.2019.104263 | 0.362 | |||
| 2019 | Ahmad A, Herndon DN, Szabo C. Oxandrolone protects against the development of multiorgan failure, modulates the systemic inflammatory response and promotes wound healing during burn injury. Burns : Journal of the International Society For Burn Injuries. 45: 671-681. PMID 31018913 DOI: 10.1016/J.Burns.2018.10.006 | 0.312 | |||
| 2019 | Ahmad A, Druzhyna N, Szabo C. Effect of 3-mercaptopyruvate sulfurtransferase deficiency on the development of multiorgan failure, inflammation and wound healing in mice subjected to burn injury. Journal of Burn Care & Research : Official Publication of the American Burn Association. PMID 30649358 DOI: 10.1093/Jbcr/Irz007 | 0.322 | |||
| 2019 | Abdollahi Govar A, Törő G, Szaniszlo P, Pavlidou A, Bibli SI, Thanki K, Resto VA, Chao C, Hellmich MR, Szabo C, Papapetropoulos A, Módis K. 3-mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics. British Journal of Pharmacology. PMID 30644090 DOI: 10.1111/Bph.14574 | 0.668 | |||
| 2019 | Pavlidou A, Bibli S, Modis K, Nagahara N, Szabo C, Fleming I, Papapetropoulos A. Abstract 631: Complementary Roles for 3-mercaptopyruvate Sulfurtransferase and Cystathionine γ-lyase in Angiogenesis Circulation Research. 125. DOI: 10.1161/res.125.suppl_1.631 | 0.658 | |||
| 2018 | Augsburger F, Szabo C. Potential role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (HS) pathway in cancer cells. Pharmacological Research. PMID 30500457 DOI: 10.1016/J.Phrs.2018.11.034 | 0.338 | |||
| 2018 | Merz T, Wepler M, Nußbaum B, Vogt J, Calzia E, Wang R, Szabo C, Radermacher P, McCook O. Cystathionine-γ-lyase expression is associated with mitochondrial respiration during sepsis-induced acute kidney injury in swine with atherosclerosis. Intensive Care Medicine Experimental. 6: 43. PMID 30343340 DOI: 10.1186/S40635-018-0208-Z | 0.336 | |||
| 2018 | Tapodi A, Bognár Z, Szabo C, Gallyas F, Sümegi B, Hocsák E. PARP inhibition induces Akt-mediated cytoprotective effects through the formation of a mitochondria-targeted phospho-ATM-NEMO-Akt-mTOR signalosome. Biochemical Pharmacology. PMID 30296409 DOI: 10.1016/J.Bcp.2018.10.005 | 0.38 | |||
| 2018 | Bibli SI, Hu J, Sigala F, Wittig I, Heidler J, Zukunft S, Tsilimigras DI, Randriamboavonjy V, Wittig J, Kojonazarov B, Schürmann C, Siragusa M, Siuda D, Luck B, Abdel Malik R, ... ... Szabo C, et al. Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein HuR to Preserve Endothelial Cell Function and Delay Atherogenesis. Circulation. PMID 29970364 DOI: 10.1161/Circulationaha.118.034757 | 0.355 | |||
| 2018 | Szczesny B, Marcatti M, Ahmad A, Montalbano M, Brunyánszki A, Bibli SI, Papapetropoulos A, Szabo C. Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells. Scientific Reports. 8: 914. PMID 29343810 DOI: 10.1038/S41598-018-19216-1 | 0.367 | |||
| 2017 | Oláh G, Módis K, Törö G, Hellmich MR, Szczesny B, Szabo C. Role of endogenous and exogenous nitric oxide, carbon monoxide and hydrogen sulfide in HCT116 colon cancer cell proliferation. Biochemical Pharmacology. PMID 29074106 DOI: 10.1016/J.Bcp.2017.10.011 | 0.684 | |||
| 2017 | Untereiner AA, Pavlidou A, Druzhyna N, Papapetropoulos A, Hellmich MR, Szabo C. Drug resistance induces the upregulation of H2S-producing enzymes in HCT116 colon cancer cells. Biochemical Pharmacology. PMID 29061341 DOI: 10.1016/J.Bcp.2017.10.007 | 0.327 | |||
| 2017 | Bibli SI, Szabo C, Chatzianastasiou A, Luck B, Zukunft S, Fleming I, Papapetropoulos A. Hydrogen sulfide preserves eNOS function by inhibiting PYK2: implications for cardiomyocyte survival and cardioprotection. Molecular Pharmacology. PMID 29030392 DOI: 10.1124/Mol.117.109645 | 0.392 | |||
| 2017 | Szabo C, Papapetropoulos A. International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H2S Levels: H2S Donors and H2S Biosynthesis Inhibitors. Pharmacological Reviews. 69: 497-564. PMID 28978633 DOI: 10.1124/Pr.117.014050 | 0.343 | |||
| 2017 | Szabo C. A timeline of hydrogen sulfide (H2S) research: from environmental toxin to biological mediator. Biochemical Pharmacology. PMID 28947277 DOI: 10.1016/J.Bcp.2017.09.010 | 0.308 | |||
| 2017 | Phillips CM, Zatarain J, Nicholls ME, Porter C, Widen SG, Thanki K, Johnson P, Jawad MU, Moyer MP, Randall JW, Hellmich JL, Maskey M, Qiu S, Wood T, Druzhyna N, ... ... Szabo C, et al. Upregulation of Cystathionine-β-synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis. Cancer Research. PMID 28923859 DOI: 10.1158/0008-5472.Can-16-3480 | 0.662 | |||
| 2017 | Korkmaz-Icöz S, Szczesny B, Marcatti M, Li S, Ruppert M, Lasitschka F, Loganathan S, Szabo C, Szabó G. Olaparib, a clinically used poly(ADP-ribose) polymerase inhibitor protects against oxidant-induced cardiac myocyte death in vitro and improves cardiac contractility during early phase after heart transplantation in a rat model in vivo. British Journal of Pharmacology. PMID 28806493 DOI: 10.1111/Bph.13983 | 0.334 | |||
| 2017 | Cross J, Stenton GR, Harwig C, Szabo C, Genovese T, Di Paola R, Esposito E, Cuzzocrea S, Mackenzie LF. AQX-1125, a small molecule SHIP1 activator, inhibits bleomycin-induced pulmonary fibrosis. British Journal of Pharmacology. PMID 28658529 DOI: 10.1111/Bph.13934 | 0.322 | |||
| 2017 | Steiger AK, Marcatti M, Szabo C, Szczesny B, Pluth MD. Inhibition of Mitochondrial Bioenergetics by Esterase-Triggered COS/H2S Donors. Acs Chemical Biology. PMID 28613823 DOI: 10.1021/Acschembio.7B00279 | 0.324 | |||
| 2017 | Bibli SI, Zhou Z, Zukunft S, Fisslthaler B, Andreadou I, Szabo C, Brouckaert P, Fleming I, Papapetropoulos A. Tyrosine phosphorylation of eNOS regulates myocardial survival after an ischaemic insult: role of PYK2. Cardiovascular Research. PMID 28444132 DOI: 10.1093/Cvr/Cvx058 | 0.312 | |||
| 2017 | Untereiner AA, Oláh G, Módis K, Hellmich MR, Szabo C. H2S-induced S-sulfhydration of lactate dehydrogenase A (LDHA) stimulates cellular bioenergetics in HCT116 colon cancer cells. Biochemical Pharmacology. PMID 28404377 DOI: 10.1016/J.Bcp.2017.03.025 | 0.696 | |||
| 2017 | Ahmad A, Druzhyna N, Szabo C. Cystathionine-gamma-lyase deficient mice are protected against the development of multiorgan failure and exhibit reduced inflammatory response during burn. Burns : Journal of the International Society For Burn Injuries. PMID 28318752 DOI: 10.1016/J.Burns.2017.02.011 | 0.318 | |||
| 2017 | Korkmaz-Icöz S, Radovits T, Loganathan S, Li S, Ruppert M, Benke K, Brlecic P, Szabó C, Karck M, Szabó G. Prolonging hypothermic ischaemic cardiac and vascular storage by inhibiting the activation of the nuclear enzyme poly(adenosine diphosphate-ribose) polymerase. European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association For Cardio-Thoracic Surgery. PMID 28204209 DOI: 10.1093/Ejcts/Ezw426 | 0.343 | |||
| 2017 | Kanagy NL, Szabo C, Papapetropoulos A. Vascular Biology of Hydrogen Sulfide. American Journal of Physiology. Cell Physiology. ajpcell.00329.2016. PMID 28148499 DOI: 10.1152/Ajpcell.00329.2016 | 0.345 | |||
| 2017 | Kozlov AV, Bahrami S, Redl H, Szabo C. Alterations in nitric oxide homeostasis during traumatic brain injury. Biochimica Et Biophysica Acta. PMID 28064018 DOI: 10.1016/J.Bbadis.2016.12.020 | 0.3 | |||
| 2017 | Zatarain JR, Thanki K, Nicholls ME, Maskey M, Jawad MU, Phillips C, Modis K, Szabo C, Chao C, Hellmich MR. Abstract 4791: Cystathionine-β-Synthase (CBS) and the progression of colorectal carcinogenesis Cancer Research. 77: 4791-4791. DOI: 10.1158/1538-7445.Am2017-4791 | 0.645 | |||
| 2017 | Phillips CM, Zatarain JR, Nicholls ME, Porter C, Widen S, Thanki K, Randall JW, Hellmich JL, Maskey M, Qiu S, Wood TG, Druzhyna N, Szczesny B, Modis K, Szabo C, et al. Abstract 3548: Hypoxia-induced Cystathionine-β-synthase (CBS) expression: impact on colonic epithelial cells metabolism, proliferation and migration Cancer Research. 77: 3548-3548. DOI: 10.1158/1538-7445.Am2017-3548 | 0.642 | |||
| 2017 | Modis K, Maskey M, Johnson P, Szabo C, Hellmich MR, Chao C. Abstract 2980: Cystathionine-beta-synthase (CBS)-derived hydrogen sulfide (H2S) supports proliferation, migration and bioenergetics in colon cancer-associated fibroblasts (CAFs) Cancer Research. 77: 2980-2980. DOI: 10.1158/1538-7445.Am2017-2980 | 0.679 | |||
| 2017 | Marcatti M, Ahmad A, Szabo C, Szczesny B. Oxidatively Damaged Mitochondrial DNA Induces Inflammation in Lung Epithelial Cells Free Radical Biology and Medicine. 112: 211. DOI: 10.1016/J.Freeradbiomed.2017.10.336 | 0.357 | |||
| 2016 | Oliveira NM, Rios EC, de Lima TM, Victorino VJ, Barbeiro H, Pinheiro da Silva F, Szabo C, Soriano FG. Sepsis induces telomere shortening: a potential mechanism responsible for delayed pathophysiological events in sepsis survivors? Molecular Medicine (Cambridge, Mass.). 22. PMID 27925632 DOI: 10.2119/Molmed.2016.00225 | 0.33 | |||
| 2016 | Grimes L, Doyle A, Miller AL, Pyles RB, Olah G, Szabo C, Hoskins S, Eaves-Pyles T. Intraluminal Flagellin Differentially Contributes to Gut Dysbiosis and Systemic Inflammation following Burn Injury. Plos One. 11: e0166770. PMID 27907005 DOI: 10.1371/Journal.Pone.0166770 | 0.321 | |||
| 2016 | Szczesny B, Marcatti M, Zatarain JR, Druzhyna N, Wiktorowicz JE, Nagy P, Hellmich MR, Szabo C. Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics. Scientific Reports. 6: 36125. PMID 27808278 DOI: 10.1038/Srep36125 | 0.338 | |||
| 2016 | Szabo C. Hydrogen sulfide, an enhancer of vascular nitric oxide signalling: mechanisms and implications. American Journal of Physiology. Cell Physiology. ajpcell.00282.2016. PMID 27784679 DOI: 10.1152/Ajpcell.00282.2016 | 0.327 | |||
| 2016 | Ahmad A, Gerö D, Olah G, Szabo C. Effect of endotoxemia in mice genetically deficient in cystathionine-γ-lyase, cystathionine-β-synthase or 3-mercaptopyruvate sulfurtransferase. International Journal of Molecular Medicine. PMID 27748832 DOI: 10.3892/Ijmm.2016.2771 | 0.319 | |||
| 2016 | López-García I, Gerő D, Szczesny B, Szoleczky P, Olah G, Módis K, Zhang K, Jungling G, Wu P, Sowers LC, DeWitt D, Prough DS, Szabo C. Development of a stretch-induced neurotrauma model for medium-throughput screening in vitro: identification of rifampicin as a neuroprotectant. British Journal of Pharmacology. PMID 27723079 DOI: 10.1111/Bph.13642 | 0.643 | |||
| 2016 | Ahmad A, Szabo C. Both the H2S biosynthesis inhibitor aminooxyacetic acid and the mitochondrially targeted H2S donor AP39 exert protective effects in a mouse model of burn injury. Pharmacological Research. PMID 27639598 DOI: 10.1016/J.Phrs.2016.09.013 | 0.347 | |||
| 2016 | Katsouda A, Bibli SI, Pyriochou A, Szabo C, Papapetropoulos A. Regulation and role of endogenously produced hydrogen sulfide in angiogenesis. Pharmacological Research. 113: 175-185. PMID 27569706 DOI: 10.1016/J.Phrs.2016.08.026 | 0.371 | |||
| 2016 | Módis K, Ju Y, Ahmad A, Untereiner AA, Altaany Z, Wu L, Szabo C, Wang R. S-sulfhydration of ATP synthase by hydrogen sulfide stimulates mitochondrial bioenergetics. Pharmacological Research. PMID 27553984 DOI: 10.1016/J.Phrs.2016.08.023 | 0.687 | |||
| 2016 | Druzhyna N, Szczesny B, Olah G, Módis K, Asimakopoulou A, Pavlidou A, Szoleczky P, Gerö D, Yanagi K, Törö G, López-García I, Myrianthopoulos V, Mikros E, Zatarain JR, Chao C, ... ... Szabo C, et al. Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer. Pharmacological Research. PMID 27521834 DOI: 10.1016/J.Phrs.2016.08.016 | 0.665 | |||
| 2016 | Zhou Z, Martin E, Sharina I, Esposito I, Szabo C, Bucci M, Cirino G, Papapetropoulos A. Regulation of soluble guanylyl cyclase redox state by hydrogen sulfide. Pharmacological Research. PMID 27378567 DOI: 10.1016/J.Phrs.2016.06.029 | 0.377 | |||
| 2016 | Chatzianastasiou A, Bibli SI, Andreadou I, Efentakis P, Kaludercic N, Wood ME, Whiteman M, Di Lisa F, Daiber A, Manolopoulos VG, Szabo C, Papapetropoulos A. Cardioprotection by H2S donors: nitric oxide-dependent and -independent mechanisms. The Journal of Pharmacology and Experimental Therapeutics. PMID 27342567 DOI: 10.1124/Jpet.116.235119 | 0.395 | |||
| 2016 | Gersztenkorn D, Coletta C, Zhu S, Ha Y, Liu H, Tie H, Zhou J, Szabo C, Zhang W, Motamedi M. Hydrogen Sulfide Contributes to Retinal Neovascularization in Ischemia-Induced Retinopathy. Investigative Ophthalmology & Visual Science. 57: 3002-3009. PMID 27273718 DOI: 10.1167/Iovs.15-18555 | 0.302 | |||
| 2016 | Chao C, Zatarain JR, Ding Y, Coletta C, Mrazek AA, Druzhyna N, Johnson P, Chen H, Hellmich JL, Asimakopoulou A, Yanagi K, Olah G, Szoleczky P, Törö G, Bohanon FJ, ... ... Szabo C, et al. Cystathionine-beta-synthase inhibition for colon cancer: Enhancement of the efficacy of aminooxyacetic acid via the prodrug approach. Molecular Medicine (Cambridge, Mass.). 22. PMID 27257787 DOI: 10.2119/Molmed.2016.00102 | 0.656 | |||
| 2016 | Gerö D, Szabo C. Glucocorticoids Suppress Mitochondrial Oxidant Production via Upregulation of Uncoupling Protein 2 in Hyperglycemic Endothelial Cells. Plos One. 11: e0154813. PMID 27128320 DOI: 10.1371/Journal.Pone.0154813 | 0.367 | |||
| 2016 | Rios EC, Soriano FG, Olah G, Gerö D, Szczesny B, Szabo C. Hydrogen sulfide modulates chromatin remodeling and inflammatory mediator production in response to endotoxin, but does not play a role in the development of endotoxin tolerance. Journal of Inflammation (London, England). 13: 10. PMID 27042162 DOI: 10.1186/S12950-016-0119-2 | 0.323 | |||
| 2016 | Brunyanszki A, Szczesny B, Virág L, Szabo C. Mitochondrial poly(ADP-ribose) polymerase: The Wizard of Oz at work. Free Radical Biology & Medicine. PMID 26964508 DOI: 10.1016/J.Freeradbiomed.2016.02.024 | 0.325 | |||
| 2016 | Ahmad A, Druzhyna N, Szabo C. Delayed Treatment with Sodium Hydrosulfide Improves Regional Blood Flow and Alleviates Cecal Ligation and Puncture (CLP) - Induced Septic Shock. Shock (Augusta, Ga.). PMID 26863032 DOI: 10.1097/Shk.0000000000000589 | 0.305 | |||
| 2016 | Szabo C. Gasotransmitters in cancer: from pathophysiology to experimental therapy. Nature Reviews. Drug Discovery. 15: 185-203. PMID 26678620 DOI: 10.1038/Nrd.2015.1 | 0.309 | |||
| 2016 | Zatarain JR, Phillips CM, Nicholls ME, Johnson P, Widen SG, Wood TG, Druzhyna N, Szczesny B, Porter C, Modis K, Szabo C, Chao C, Hellmich MR. Abstract 4276: Cystathionine-β-synthase overexpression increases cell proliferation, migration, bioenergetics and tumorigenesis in a non-tumorigenic colorectal cancer (CRC) cell line Cancer Research. 76: 4276-4276. DOI: 10.1158/1538-7445.Am2016-4276 | 0.662 | |||
| 2016 | Marcatti M, Brunyanszki A, Ahmad A, Szabo C, Szczesny B. Damaged Mitochondrial DNA as a Potent Inducer of Lung Inflammation Free Radical Biology and Medicine. 100. DOI: 10.1016/J.Freeradbiomed.2016.10.160 | 0.353 | |||
| 2015 | Szczesny B, Brunyánszki A, Ahmad A, Oláh G, Porter C, Toliver-Kinsky T, Sidossis L, Herndon DN, Szabo C. Time-Dependent and Organ-Specific Changes in Mitochondrial Function, Mitochondrial DNA Integrity, Oxidative Stress and Mononuclear Cell Infiltration in a Mouse Model of Burn Injury. Plos One. 10: e0143730. PMID 26630679 DOI: 10.1371/Journal.Pone.0143730 | 0.349 | |||
| 2015 | Ahmad A, Olah G, Szczesny B, Wood ME, Whiteman M, Szabo C. AP39, A Mitochondrially- Targeted Hydrogen Sulfide Donor, Exerts Protective Effects in Renal Epithelial Cells Subjected to Oxidative Stress in Vitro and in Acute Renal Injury in Vivo. Shock (Augusta, Ga.). PMID 26513708 DOI: 10.1097/Shk.0000000000000478 | 0.378 | |||
| 2015 | Snijder PM, Baratashvili M, Grzeschik NA, Leuvenink HG, Kuijpers L, Huitema S, Schaap O, Giepmans BN, Kuipers J, Miljkovic JL, Mitrovic A, Bos EM, Szabó C, Kampinga HH, Dijkers PF, et al. Overexpression of cystathionine γ-lyase suppresses detrimental effects of spinocerebellar ataxia type 3. Molecular Medicine (Cambridge, Mass.). PMID 26467707 DOI: 10.2119/Molmed.2015.00221 | 0.31 | |||
| 2015 | Pribis JP, Al-Abed Y, Yang H, Gero D, Xu H, Montenegro MF, Bauer EM, Kim S, Chavan SS, Cai C, Li T, Szoleczky P, Szabo C, Tracey KJ, Billiar TR. The HIV protease inhibitor saquinavir inhibits HMGB1 driven inflammation by targeting the interaction of cathepsin V with TLR4/MyD88. Molecular Medicine (Cambridge, Mass.). PMID 26349060 DOI: 10.2119/Molmed.2015.00197 | 0.303 | |||
| 2015 | Brunyanszki A, Erdelyi K, Szczesny B, Olah G, Salomao R, Herndon DN, Szabo C. Upregulation and mitochondrial sequestration of hemoglobins occurs in circulating leukocytes during critical illness, conferring a cytoprotective phenotype. Molecular Medicine (Cambridge, Mass.). PMID 26322851 DOI: 10.2119/Molmed.2015.00187 | 0.389 | |||
| 2015 | Andreadou I, Iliodromitis EK, Szabo C, Papapetropoulos A. Hydrogen sulfide and PKG in ischemia-reperfusion injury: sources, signaling, accelerators and brakes. Basic Research in Cardiology. 110: 510. PMID 26318600 DOI: 10.1007/S00395-015-0510-9 | 0.316 | |||
| 2015 | Oláh G, Szczesny B, Brunyánszki A, López-García IA, Gerö D, Radák Z, Szabo C. Differentiation-Associated Downregulation of Poly(ADP-Ribose) Polymerase-1 Expression in Myoblasts Serves to Increase Their Resistance to Oxidative Stress. Plos One. 10: e0134227. PMID 26218895 DOI: 10.1371/Journal.Pone.0134227 | 0.365 | |||
| 2015 | Hellmich MR, Szabo C. Hydrogen Sulfide and Cancer. Handbook of Experimental Pharmacology. 230: 233-41. PMID 26162838 DOI: 10.1007/978-3-319-18144-8_12 | 0.347 | |||
| 2015 | Wang R, Szabo C, Ichinose F, Ahmed A, Whiteman M, Papapetropoulos A. The role of H2S bioavailability in endothelial dysfunction. Trends in Pharmacological Sciences. PMID 26071118 DOI: 10.1016/J.Tips.2015.05.007 | 0.338 | |||
| 2015 | Porter C, Herndon DN, Bhattarai N, Ogunbileje JO, Szczesny B, Szabo C, Toliver-Kinsky T, Sidossis LS. Severe Burn Injury Induces Thermogenically Functional Mitochondria in Murine White Adipose Tissue. Shock (Augusta, Ga.). PMID 26009824 DOI: 10.1097/Shk.0000000000000410 | 0.307 | |||
| 2015 | Rios EC, Szczesny B, Soriano FG, Olah G, Szabo C. Hydrogen sulfide attenuates cytokine production through the modulation of chromatin remodeling. International Journal of Molecular Medicine. 35: 1741-6. PMID 25873160 DOI: 10.3892/Ijmm.2015.2176 | 0.347 | |||
| 2015 | Bibli SI, Andreadou I, Chatzianastasiou A, Tzimas C, Sanoudou D, Kranias E, Brouckaert P, Coletta C, Szabo C, Kremastinos DT, Iliodromitis EK, Papapetropoulos A. Cardioprotection by H2S engages a cGMP-dependent protein kinase G/phospholamban pathway. Cardiovascular Research. 106: 432-42. PMID 25870184 DOI: 10.1093/Cvr/Cvv129 | 0.369 | |||
| 2015 | Li H, Ma Y, Escaffre O, Ivanciuc T, Komaravelli N, Kelley JP, Coletta C, Szabo C, Rockx B, Garofalo RP, Casola A. Role of hydrogen sulfide in paramyxovirus infections. Journal of Virology. 89: 5557-68. PMID 25740991 DOI: 10.1128/Jvi.00264-15 | 0.332 | |||
| 2015 | Coletta C, Módis K, Szczesny B, Brunyánszki A, Oláh G, Rios EC, Yanagi K, Ahmad A, Papapetropoulos A, Szabo C. Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia and Restoration by DL-α-Lipoic Acid. Molecular Medicine (Cambridge, Mass.). 21: 1-14. PMID 25715337 DOI: 10.2119/Molmed.2015.00035 | 0.7 | |||
| 2015 | Szabo C. Old dog, new tricks: Proangiogenic effect of adenosine via stimulation of thrombospondin-1 in macrophages Journal of Leukocyte Biology. 97: 3-5. PMID 25561440 DOI: 10.1189/Jlb.2Ce0614-304R | 0.348 | |||
| 2015 | Yang H, Wang H, Ju Z, Ragab AA, Lundbäck P, Long W, Valdes-Ferrer SI, He M, Pribis JP, Li J, Lu B, Gero D, Szabo C, Antoine DJ, Harris HE, et al. MD-2 is required for disulfide HMGB1-dependent TLR4 signaling. The Journal of Experimental Medicine. 212: 5-14. PMID 25559892 DOI: 10.1084/Jem.20141318 | 0.32 | |||
| 2015 | Hellmich MR, Coletta C, Chao C, Szabo C. The therapeutic potential of cystathionine β-synthetase/hydrogen sulfide inhibition in cancer. Antioxidants & Redox Signaling. 22: 424-48. PMID 24730679 DOI: 10.1089/Ars.2014.5933 | 0.331 | |||
| 2015 | Zatarain JR, Mrazek AA, Johnson P, Pang L, Ding Y, Zhou J, Szabo C, Chao C, Hellmich MR. Tu1975 H2S Inhibition of Cystathionine-β-Synthase (CBS) Using Novel Prodrug Decreases Colorectal Cancer Xenograft Growth With Less Toxicity Than Aminooxyacetic Acid (AOAA) Gastroenterology. 148: S-950. DOI: 10.1016/S0016-5085(15)33242-X | 0.318 | |||
| 2015 | Módis K, Ju Y, Altaany Z, Untereiner AA, Yang G, Wu L, Szabo C, Wang R. Hydrogen sulfide-induced S-sulfhydration of ATP synthase stimulates mitochondrial bioenergetics Nitric Oxide. 47: S53-S54. DOI: 10.1016/J.Niox.2015.02.128 | 0.65 | |||
| 2015 | Coletta C, Modis K, Brunyanszki A, Olah G, Rios ECS, Yanagi K, Ahmad A, Papapetropoulos A, Szczesny B, Szabo C. PP78 - The biological effects of 3-mercaptopyruvate include vasodilatation, hypotension, stimulation of angiogenesis and stimulation of cellular bioenergetics: Relative contribution of enzymatic versus non-enzymatic hydrogen sulfide production Nitric Oxide. 47. DOI: 10.1016/J.Niox.2015.02.108 | 0.64 | |||
| 2015 | Brunyanszki A, Erdelyi K, Olah G, Coletta C, Yanagi K, Szczesny B, Herndon D, Szabo C. PP77 – Upregulation of hemoglobins in burn injury confers protection against hydrogen sulfide mediated cellular dysfunction Nitric Oxide. 47. DOI: 10.1016/J.Niox.2015.02.107 | 0.306 | |||
| 2014 | Szczesny B, Brunyanszki A, Olah G, Mitra S, Szabo C. Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function. Nucleic Acids Research. 42: 13161-73. PMID 25378300 DOI: 10.1093/Nar/Gku1089 | 0.311 | |||
| 2014 | Coletta C, Módis K, Oláh G, Brunyánszki A, Herzig DS, Sherwood ER, Ungvári Z, Szabo C. Endothelial dysfunction is a potential contributor to multiple organ failure and mortality in aged mice subjected to septic shock: preclinical studies in a murine model of cecal ligation and puncture. Critical Care (London, England). 18: 511. PMID 25223540 DOI: 10.1186/s13054-014-0511-3 | 0.655 | |||
| 2014 | Brunyanszki A, Olah G, Coletta C, Szczesny B, Szabo C. Regulation of mitochondrial poly(ADP-Ribose) polymerase activation by the β-adrenoceptor/cAMP/protein kinase A axis during oxidative stress. Molecular Pharmacology. 86: 450-62. PMID 25069723 DOI: 10.1124/Mol.114.094318 | 0.377 | |||
| 2014 | Matallo J, Vogt J, McCook O, Wachter U, Tillmans F, Groeger M, Szabo C, Georgieff M, Radermacher P, Calzia E. Sulfide-inhibition of mitochondrial respiration at very low oxygen concentrations Nitric Oxide. 41: 79-84. PMID 24963794 DOI: 10.1016/J.Niox.2014.06.004 | 0.301 | |||
| 2014 | Gerö D, Szoleczky P, Chatzianastasiou A, Papapetropoulos A, Szabo C. Modulation of poly(ADP-ribose) polymerase-1 (PARP-1)-mediated oxidative cell injury by ring finger protein 146 (RNF146) in cardiac myocytes. Molecular Medicine (Cambridge, Mass.). 20: 313-28. PMID 24842055 DOI: 10.2119/Molmed.2014.00102 | 0.384 | |||
| 2014 | Szczesny B, Módis K, Yanagi K, Coletta C, Le Trionnaire S, Perry A, Wood ME, Whiteman M, Szabo C. AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 41: 120-30. PMID 24755204 DOI: 10.1016/J.Niox.2014.04.008 | 0.689 | |||
| 2014 | Módis K, Coletta C, Asimakopoulou A, Szczesny B, Chao C, Papapetropoulos A, Hellmich MR, Szabo C. Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-β-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 41: 146-56. PMID 24667534 DOI: 10.1016/J.Niox.2014.03.001 | 0.687 | |||
| 2014 | McCook O, Radermacher P, Volani C, Asfar P, Ignatius A, Kemmler J, Möller P, Szabó C, Whiteman M, Wood ME, Wang R, Georgieff M, Wachter U. H2S during circulatory shock: some unresolved questions. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 41: 48-61. PMID 24650697 DOI: 10.1016/J.Niox.2014.03.163 | 0.328 | |||
| 2014 | Mukhopadhyay P, Rajesh M, Cao Z, Horváth B, Park O, Wang H, Erdelyi K, Holovac E, Wang Y, Liaudet L, Hamdaoui N, Lafdil F, Haskó G, Szabo C, Boulares AH, et al. Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis. Hepatology (Baltimore, Md.). 59: 1998-2009. PMID 24089324 DOI: 10.1002/Hep.26763 | 0.323 | |||
| 2014 | Szabo C, Ransy C, Módis K, Andriamihaja M, Murghes B, Coletta C, Olah G, Yanagi K, Bouillaud F. Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms. British Journal of Pharmacology. 171: 2099-122. PMID 23991830 DOI: 10.1111/Bph.12369 | 0.677 | |||
| 2014 | Módis K, Bos EM, Calzia E, van Goor H, Coletta C, Papapetropoulos A, Hellmich MR, Radermacher P, Bouillaud F, Szabo C. Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II. Pathophysiological and therapeutic aspects. British Journal of Pharmacology. 171: 2123-46. PMID 23991749 DOI: 10.1111/Bph.12368 | 0.377 | |||
| 2014 | Le Trionnaire S, Perry A, Szczesny B, Szabo C, Winyard PG, Whatmore JL, Wood ME, Whiteman M. The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl) triphenylphosphonium bromide (AP39) Medchemcomm. 5: 728-736. DOI: 10.1039/C3Md00323J | 0.355 | |||
| 2014 | Whiteman M, Szabo C. Novel mitochondria-targeted hydrogen sulfide (H2S) donors stimulate cellular bioenergetics and protect endothelial cells from oxidative stress-induced injury and mitochondrial DNA damage. Nitric Oxide. 42: 142. DOI: 10.1016/J.Niox.2014.09.128 | 0.387 | |||
| 2014 | Asimakopoulou A, Zhou Z, Coletta C, Szabo C, Papapetropoulos A. P98 Tetracyclin antibiotics as inhibitors of H2S synthesis Nitric Oxide. 39. DOI: 10.1016/J.Niox.2014.03.148 | 0.359 | |||
| 2014 | Coletta C, Szabo C. P35 Exacerbation of the septic response in cystathionine-gamma-lyase deficient mice Nitric Oxide. 39. DOI: 10.1016/J.Niox.2014.03.085 | 0.304 | |||
| 2014 | Gero D, Szczesny B, Módis K, Yanagi K, Wood ME, Perry A, Szabo C, Whiteman M. P22: Mitochondira-targeted hydrogen sulfide donors AP39 and AP123 attenuate hyperglycaemia-induced oxidative stress and loss of bioenergetics in microvascular endothelial cells Nitric Oxide. 39. DOI: 10.1016/J.Niox.2014.03.072 | 0.682 | |||
| 2014 | Szczesny B, Módis K, Yanagi K, Trionnaire SL, Wood ME, Whiteman M, Szabo C. P21: Cytoprotective effects of AP39, a mitochondrially targeted hydrogen sulfide donor in oxidatively stressed endothelial cells: Protection against the loss of cell viability and bioenergetics and attenuation of mitochondrial DNA injury Nitric Oxide. 39. DOI: 10.1016/J.Niox.2014.03.071 | 0.682 | |||
| 2014 | Hellmich MR, Coletta C, Chao C, Dikman A, Szabo C. P20: Pro- and anti-proliferative effects of hydrogen sulfide in colon cancer cells: A unifying hypothesis Nitric Oxide. 39. DOI: 10.1016/J.Niox.2014.03.070 | 0.353 | |||
| 2014 | Chao C, Bohannon FJ, Mrazek A, Coletta C, Szabo C, Hellmich MR. P19 Cysthionine-β-synthetase inhibition in combination with standard-chemotherapy decreases colorectal cancer metastasis to the liver Nitric Oxide. 39. DOI: 10.1016/J.Niox.2014.03.069 | 0.32 | |||
| 2014 | Coletta C, Módis K, Asimakopoulou A, Szczesny B, Chao C, Papapetropoulos A, Hellmich MR, Szabo C. P17 Modulatory effect of S-adenyl-methionine, an allosteric activator of cystathionine-beta-synthase on the proliferation and bioenergetics of colon cancer cells: Mechanism of action Nitric Oxide. 39. DOI: 10.1016/J.Niox.2014.03.067 | 0.68 | |||
| 2014 | Coletta C, Dikman A, Szabo C, Hellmich MR, Chao C. P16 Hydrogen sulfide stimulates colorectal cancer-associated fibroblast proliferation and migration Nitric Oxide. 39. DOI: 10.1016/J.Niox.2014.03.066 | 0.326 | |||
| 2014 | Coletta C, Módis K, Oláh G, Rios E, Yanagi K, Szczesny B, Papapetropoulos A, Szabo C. S8-1 Pathophysiological changes in hyrogen sulfide homeostasis during diabetic complications Nitric Oxide. 39. DOI: 10.1016/J.Niox.2014.03.037 | 0.683 | |||
| 2014 | Hellmich MR, Szabo C. S6-5 Role of cystathionine-beta synthase and its product, hydrogen sulfide in cancer biology Nitric Oxide. 39. DOI: 10.1016/J.Niox.2014.03.030 | 0.344 | |||
| 2014 | Brunyanszki A, Olah G, Coletta C, Szczesny B, Szabo C. Oxidative Stress Induces an Early-Onset Mitochondrial Poly(ADP-Ribose) Polymerase Activation in U937 Cells Free Radical Biology and Medicine. 76. DOI: 10.1016/J.Freeradbiomed.2014.10.550 | 0.347 | |||
| 2014 | Yanagi K, Szczesny B, Brunyanszki A, Rios E, Szabo C. 115 – High Glucose Exposure Induces a Compensatory Up-Regulation of Mitochondrial Function, Resulting in Cellular Resistance to Oxidative Stress in Human Endothelial Cells Free Radical Biology and Medicine. 76. DOI: 10.1016/J.Freeradbiomed.2014.10.430 | 0.332 | |||
| 2014 | Szczesny B, Brunyanszki A, Olah G, Szabo C. 162 - Mitochondrial PARP1 Negatively Regulates Mitochondrial DNA Repair and Biogenesis ensitizing Cells to Oxidative Stress Free Radical Biology and Medicine. 76. DOI: 10.1016/J.Freeradbiomed.2014.10.356 | 0.307 | |||
| 2014 | Gero D, Szczesny B, Perry A, Modis K, Wood ME, Szabo C, Whiteman M. 277 – Novel Mitochondria-Targeted Hydrogen Sulfide (H2S) Donors AP39 and AP123 Attenuate Hyperglycaemia-Induced Oxidative Stress and Loss of Bioenergetics in Microvascular Endothelial Cells Free Radical Biology and Medicine. 76. DOI: 10.1016/J.Freeradbiomed.2014.10.254 | 0.674 | |||
| 2014 | Szabo C, Coletta C, Modis K, Olah G, Brunyanszki A, Rios E, Yanagi K, Szczesny B, Papapetropoulos A. Regulation of Vascular Tone and Angiogenesis by the 3-Mercaptopyruvate Sulfur Transferase / Hydrogen Sulfide System under Physiological Conditions and during Diabetes Free Radical Biology and Medicine. 76. DOI: 10.1016/J.Freeradbiomed.2014.10.251 | 0.631 | |||
| 2014 | Modis K, Coletta C, Szczesny B, Olah G, Szabo C. 267 – Diabetes Impairs the 3-Mercaptopyruvate Sulfurtransferase / Hydrogen Sulfide Mediated Cellular Bioenergetic System: Protection by Alpha-Lipoic Acid Free Radical Biology and Medicine. 76. DOI: 10.1016/J.Freeradbiomed.2014.10.244 | 0.624 | |||
| 2014 | Suzuki K, Tanaka S, Yanagi K, Iijima T, Niitani M, Coletta C, Szabo C, Aso Y. Epalrestat induces cell proliferation and migration in endothelial cells via mTOR activation through PI3/Akt signaling Diabetology International. 5: 105-111. DOI: 10.1007/S13340-013-0138-7 | 0.344 | |||
| 2013 | Szczesny B, Olah G, Walker DK, Volpi E, Rasmussen BB, Szabo C, Mitra S. Deficiency in repair of the mitochondrial genome sensitizes proliferating myoblasts to oxidative damage. Plos One. 8: e75201. PMID 24066171 DOI: 10.1371/Journal.Pone.0075201 | 0.307 | |||
| 2013 | Módis K, Panopoulos P, Coletta C, Papapetropoulos A, Szabo C. Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase A. Biochemical Pharmacology. 86: 1311-9. PMID 24012591 DOI: 10.1016/J.Bcp.2013.08.064 | 0.663 | |||
| 2013 | Szabo C, Hellmich MR. Endogenously produced hydrogen sulfide supports tumor cell growth and proliferation. Cell Cycle (Georgetown, Tex.). 12: 2915-6. PMID 23974103 DOI: 10.4161/Cc.26064 | 0.378 | |||
| 2013 | Eaves-Pyles T, Patel J, Arigi E, Cong Y, Cao A, Garg N, Dhiman M, Pyles RB, Arulanandam B, Miller AL, Popov VL, Soong L, Carlsen ED, Coletta C, Szabo C, et al. Immunomodulatory and antibacterial effects of cystatin 9 against Francisella tularensis. Molecular Medicine (Cambridge, Mass.). 19: 263-75. PMID 23922243 DOI: 10.2119/Molmed.2013.00081 | 0.318 | |||
| 2013 | Szabo C, Coletta C, Chao C, Módis K, Szczesny B, Papapetropoulos A, Hellmich MR. Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer. Proceedings of the National Academy of Sciences of the United States of America. 110: 12474-9. PMID 23836652 DOI: 10.1073/Pnas.1306241110 | 0.348 | |||
| 2013 | Gerö D, Szoleczky P, Módis K, Pribis JP, Al-Abed Y, Yang H, Chevan S, Billiar TR, Tracey KJ, Szabo C. Identification of pharmacological modulators of HMGB1-induced inflammatory response by cell-based screening. Plos One. 8: e65994. PMID 23799067 DOI: 10.1371/Journal.Pone.0065994 | 0.66 | |||
| 2013 | Erdélyi K, Pacher P, Virág L, Szabó C. Role of poly(ADP-ribosyl)ation in a 'two-hit' model of hypoxia and oxidative stress in human A549 epithelial cells in vitro. International Journal of Molecular Medicine. 32: 339-46. PMID 23722590 DOI: 10.3892/Ijmm.2013.1397 | 0.406 | |||
| 2013 | Módis K, Asimakopoulou A, Coletta C, Papapetropoulos A, Szabo C. Oxidative stress suppresses the cellular bioenergetic effect of the 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway. Biochemical and Biophysical Research Communications. 433: 401-7. PMID 23537657 DOI: 10.1016/J.Bbrc.2013.02.131 | 0.7 | |||
| 2013 | Coletta C, Szabo C. Potential role of hydrogen sulfide in the pathogenesis of vascular dysfunction in septic shock Current Vascular Pharmacology. 11: 208-221. PMID 23506499 DOI: 10.2174/1570161111311020010 | 0.354 | |||
| 2013 | Curtin NJ, Szabo C. Therapeutic applications of PARP inhibitors: anticancer therapy and beyond. Molecular Aspects of Medicine. 34: 1217-56. PMID 23370117 DOI: 10.1016/J.Mam.2013.01.006 | 0.312 | |||
| 2013 | Módis K, Gerő D, Stangl R, Rosero O, Szijártó A, Lotz G, Mohácsik P, Szoleczky P, Coletta C, Szabó C. Adenosine and inosine exert cytoprotective effects in an in vitro model of liver ischemia-reperfusion injury. International Journal of Molecular Medicine. 31: 437-46. PMID 23232950 DOI: 10.3892/Ijmm.2012.1203 | 0.676 | |||
| 2013 | Gerö D, Szoleczky P, Suzuki K, Módis K, Oláh G, Coletta C, Szabo C. Cell-based screening identifies paroxetine as an inhibitor of diabetic endothelial dysfunction. Diabetes. 62: 953-64. PMID 23223176 DOI: 10.2337/Db12-0789 | 0.687 | |||
| 2013 | Tucsek Z, Gautam T, Sonntag WE, Toth P, Saito H, Salomao R, Szabo C, Csiszar A, Ungvari Z. Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 68: 652-60. PMID 23183901 DOI: 10.1093/Gerona/Gls232 | 0.35 | |||
| 2013 | Stenton GR, MacKenzie LF, Tam P, Harwig C, Raymond J, Toews J, Wu J, Ogden N, MacRury T, Szabo C. Characterization of AQX-1125, a small-molecule SHIP1 activator Part 1. Effects on inflammatory cell activation and chemotaxis in vitro and pharmacokinetic characterization in vivo British Journal of Pharmacology. 168: 1506-1518. PMID 23121445 DOI: 10.1111/Bph.12039 | 0.363 | |||
| 2013 | Stenton GR, MacKenzie LF, Tam P, Cross JL, Harwig C, Raymond J, Toews J, Chernoff D, MacRury T, Szabo C. Characterization of AQX-1125, a small-molecule SHIP1 activator Part 2. Efficacy studies in allergic and pulmonary inflammation models in vivo British Journal of Pharmacology. 168: 1519-1529. PMID 23121409 DOI: 10.1111/Bph.12038 | 0.306 | |||
| 2013 | Módis K, Coletta C, Erdélyi K, Papapetropoulos A, Szabo C. Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 601-11. PMID 23104984 DOI: 10.1096/Fj.12-216507 | 0.676 | |||
| 2013 | Wesseling S, Abrahams AC, Szabo C, Goor Hv, Joles JA. Circulating Hydrogen Sulfide is Stored as Labile Sulfurs in Albumin Nitric Oxide. 31. DOI: 10.1016/J.Niox.2013.06.107 | 0.309 | |||
| 2013 | Módis K, Coletta C, Chao C, Papapetropoulos A, Hellmich M, Szabo C. P35 Cystathionine-β-synthase (CBS)-derived hydrogen sulfide (H2S) supports cellular bioenergetics in colon cancer cells in vitro Nitric Oxide. 31. DOI: 10.1016/J.Niox.2013.06.097 | 0.703 | |||
| 2013 | McCook O, Scheuerle A, Wagner F, Matallo J, Calzia E, Möller P, Szabó C, Radermacher P. P32 Effect of co-morbidity on kidney expression of H2S-producing enzymes during porcine I/R injury Nitric Oxide. 31. DOI: 10.1016/J.Niox.2013.06.094 | 0.313 | |||
| 2013 | Chao C, Coletta C, Módis K, Papapetropoulos A, Szabo C, Hellmich M. P08 Cystathionine-β-synthase (CBS)-derived hydrogen sulfide (H2S) supports colorectal tumor growth and angiogenesis in vivo Nitric Oxide. 31. DOI: 10.1016/J.Niox.2013.06.070 | 0.659 | |||
| 2013 | Módis K, Panopoulos P, Olah G, Coletta C, Papapetropoulos A, Szabo C. OP21 Role of phosphodiesterase inhibition and modulation of mitochondrial cAMP levels in the bioenergetic effect of hydrogen sulfide in isolated mitochondria Nitric Oxide. 31. DOI: 10.1016/J.Niox.2013.06.051 | 0.677 | |||
| 2013 | Coletta C, Chao C, Módis K, Papapetropoulos A, Hellmich M, Szabo C. OP17 Cystathionine-β-synthase (CBS) is upregulated in colorectal cancer cells and promotes their proliferation Nitric Oxide. 31. DOI: 10.1016/J.Niox.2013.06.047 | 0.668 | |||
| 2013 | Szabo C. PL12 Molecular mechanisms and therapeutic implications of the pro-angiogenic effect of hydrogen sulfide Nitric Oxide. 31. DOI: 10.1016/J.Niox.2013.06.022 | 0.366 | |||
| 2013 | Radermacher P, McCook O, Asfar P, Calzia E, Wood ME, Szabó C, Whiteman M, Wang R. PL03 Expression of H2S-catalyzing enzymes during “acute chronic disease” Nitric Oxide. 31: S12-S13. DOI: 10.1016/J.Niox.2013.06.013 | 0.339 | |||
| 2012 | Coletta C, Papapetropoulos A, Erdelyi K, Olah G, Módis K, Panopoulos P, Asimakopoulou A, Gerö D, Sharina I, Martin E, Szabo C. Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation. Proceedings of the National Academy of Sciences of the United States of America. 109: 9161-6. PMID 22570497 DOI: 10.1073/Pnas.1202916109 | 0.675 | |||
| 2012 | Zhou Z, von Wantoch Rekowski M, Coletta C, Szabo C, Bucci M, Cirino G, Topouzis S, Papapetropoulos A, Giannis A. Thioglycine and L-thiovaline: biologically active H₂S-donors. Bioorganic & Medicinal Chemistry. 20: 2675-8. PMID 22436388 DOI: 10.1016/J.Bmc.2012.02.028 | 0.331 | |||
| 2012 | Lange M, Szabo C, Traber DL, Horvath E, Hamahata A, Nakano Y, Traber LD, Cox RA, Schmalstieg FC, Herndon DN, Enkhbaatar P. Time profile of oxidative stress and neutrophil activation in ovine acute lung injury and sepsis. Shock (Augusta, Ga.). 37: 468-72. PMID 22266977 DOI: 10.1097/Shk.0B013E31824B1793 | 0.31 | |||
| 2012 | Módis K, Gero D, Erdélyi K, Szoleczky P, DeWitt D, Szabo C. Cellular bioenergetics is regulated by PARP1 under resting conditions and during oxidative stress. Biochemical Pharmacology. 83: 633-43. PMID 22198485 DOI: 10.1016/J.Bcp.2011.12.014 | 0.658 | |||
| 2012 | Szabo C. Roles of hydrogen sulfide in the pathogenesis of diabetes mellitus and its complications Antioxidants and Redox Signaling. 17: 68-80. PMID 22149162 DOI: 10.1089/Ars.2011.4451 | 0.304 | |||
| 2012 | Szoleczky P, Módis K, Nagy N, Dóri Tóth Z, Dewitt D, Szabó C, Gero D. Identification of agents that reduce renal hypoxia-reoxygenation injury using cell-based screening: Purine nucleosides are alternative energy sources in LLC-PK1 cells during hypoxia Archives of Biochemistry and Biophysics. 517: 53-70. PMID 22100704 DOI: 10.1016/J.Abb.2011.11.005 | 0.669 | |||
| 2012 | Maybauer MO, Maybauer DM, Fraser JF, Westphal M, Szabó C, Cox RA, Hawkins HK, Traber LD, Traber DL. Combined recombinant human activated protein C and ceftazidime prevent the onset of acute respiratory distress syndrome in severe sepsis. Shock (Augusta, Ga.). 37: 170-6. PMID 22089200 DOI: 10.1097/Shk.0B013E31823Ca8Ee | 0.304 | |||
| 2012 | Modis K, Coletta C, Papapetropoulos A, Szabo C. P25 Exogenous and endogenous H2S stimulates mitochondrial electron transport and cellular bioenergetics in hepatocytes Nitric Oxide. 27. DOI: 10.1016/J.Niox.2012.08.026 | 0.674 | |||
| 2012 | Coletta C, Papapetropoulos A, Erdelyi K, Olah G, Modis K, Panopoulos P, Asimakopoulou A, Gero D, Szabo C. P23 The angiogenic and vasorelaxant effect of H2S require the endogenous production of NO, while the angiogenic and vasorelaxant effect of NO require the endogenous production of H2S Nitric Oxide. 27. DOI: 10.1016/J.Niox.2012.08.024 | 0.685 | |||
| 2011 | Horvath EM, Zsengellér ZK, Szabo C. Quantification of PARP activity in human tissues: ex vivo assays in blood cells and immunohistochemistry in human biopsies. Methods in Molecular Biology (Clifton, N.J.). 780: 267-75. PMID 21870266 DOI: 10.1007/978-1-61779-270-0_16 | 0.345 | |||
| 2011 | Marazioti A, Bucci M, Coletta C, Vellecco V, Baskaran P, Szabó C, Cirino G, Marques AR, Guerreiro B, Gonçalves AM, Seixas JD, Beuve A, Romão CC, Papapetropoulos A. Inhibition of nitric oxide-stimulated vasorelaxation by carbon monoxide-releasing molecules. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 2570-6. PMID 21836072 DOI: 10.1161/Atvbaha.111.229039 | 0.304 | |||
| 2011 | Oláh G, Módis K, Gero D, Suzuki K, Dewitt D, Traber DL, Szabó C. Cytoprotective effect of γ-tocopherol against tumor necrosis factor α induced cell dysfunction in L929 cells. International Journal of Molecular Medicine. 28: 711-20. PMID 21822532 DOI: 10.3892/Ijmm.2011.765 | 0.692 | |||
| 2011 | Suzuki K, Olah G, Modis K, Coletta C, Kulp G, Gerö D, Szoleczky P, Chang T, Zhou Z, Wu L, Wang R, Papapetropoulos A, Szabo C. Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function. Proceedings of the National Academy of Sciences of the United States of America. 108: 13829-34. PMID 21808008 DOI: 10.1073/Pnas.1105121108 | 0.699 | |||
| 2011 | Kiss L, Benko R, Kovács E, Szerafin T, Módis K, Szabó C, Lacza Z. Human internal thoracic artery grafts exhibit severe morphological and functional damage and spasmic vasomotion due to oxidative stress. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research. 17: CR411-6. PMID 21709636 DOI: 10.12659/Msm.881853 | 0.663 | |||
| 2011 | Asmussen S, Bartha E, Olah G, Sbrana E, Rehberg SW, Yamamoto Y, Enkhbaatar P, Hawkins HK, Ito H, Cox RA, Traber LD, Traber DL, Szabo C. The Angiotensin-converting enzyme inhibitor captopril inhibits poly(adp-ribose) polymerase activation and exerts beneficial effects in an ovine model of burn and smoke injury. Shock (Augusta, Ga.). 36: 402-9. PMID 21701415 DOI: 10.1097/Shk.0B013E318228F614 | 0.3 | |||
| 2011 | Bartha E, Solti I, Szabo A, Olah G, Magyar K, Szabados E, Kalai T, Hideg K, Toth K, Gero D, Szabo C, Sumegi B, Halmosi R. Regulation of kinase cascade activation and heat shock protein expression by poly(ADP-ribose) polymerase inhibition in doxorubicin-induced heart failure. Journal of Cardiovascular Pharmacology. 58: 380-91. PMID 21697725 DOI: 10.1097/Fjc.0B013E318225C21E | 0.33 | |||
| 2011 | Oláh G, Finnerty CC, Sbrana E, Elijah I, Gerö D, Herndon DN, Szabó C. Increased poly(ADP-ribosyl)ation in skeletal muscle tissue of pediatric patients with severe burn injury: prevention by propranolol treatment. Shock (Augusta, Ga.). 36: 18-23. PMID 21368715 DOI: 10.1097/Shk.0B013E3182168D8F | 0.323 | |||
| 2011 | Bartha E, Asmussen S, Olah G, Rehberg SW, Yamamoto Y, Traber DL, Szabo C. Burn and smoke injury activates poly(ADP-ribose)polymerase in circulating leukocytes. Shock (Augusta, Ga.). 36: 144-8. PMID 21330947 DOI: 10.1097/Shk.0B013E318212988C | 0.331 | |||
| 2011 | Soriano FG, Lorigados CB, Pacher P, Szabó C. Effects of a potent peroxynitrite decomposition catalyst in murine models of endotoxemia and sepsis. Shock (Augusta, Ga.). 35: 560-6. PMID 21263378 DOI: 10.1097/Shk.0B013E31820Fe5D5 | 0.356 | |||
| 2011 | Szabó C, Papapetropoulos A. Hydrogen sulphide and angiogenesis: mechanisms and applications. British Journal of Pharmacology. 164: 853-65. PMID 21198548 DOI: 10.1111/J.1476-5381.2010.01191.X | 0.365 | |||
| 2011 | Szabó G, Veres G, Radovits T, Gero D, Módis K, Miesel-Gröschel C, Horkay F, Karck M, Szabó C. Cardioprotective effects of hydrogen sulfide. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 25: 201-10. PMID 21094267 DOI: 10.1016/J.Niox.2010.11.001 | 0.676 | |||
| 2011 | Maybauer DM, Maybauer MO, Szabó C, Cox RA, Westphal M, Kiss L, Horvath EM, Traber LD, Hawkins HK, Salzman AL, Southan GJ, Herndon DN, Traber DL. The peroxynitrite catalyst WW-85 improves pulmonary function in ovine septic shock. Shock (Augusta, Ga.). 35: 148-55. PMID 20577150 DOI: 10.1097/Shk.0B013E3181Eb4556 | 0.328 | |||
| 2011 | Stangl R, Szijártó A, Ónody P, Tamás J, Tátrai M, Hegedus V, Blázovics A, Lotz G, Kiss A, Módis K, Gero D, Szabó C, Kupcsulik P, Harsányi L. Reduction of liver ischemia-reperfusion injury via glutamine pretreatment. The Journal of Surgical Research. 166: 95-103. PMID 20080263 DOI: 10.1016/J.Jss.2009.09.047 | 0.63 | |||
| 2011 | Szabo C, Wu CC. Role of Nitric Oxide in the Development of Vascular Contractile Dysfunction in Circulatory Shock Journal of Medical Sciences. 31: 1-16. DOI: 10.6136/Jms.2011.31(1).001 | 0.329 | |||
| 2010 | Melo ES, Barbeiro DF, Gorjão R, Rios EC, Vasconcelos D, Velasco IT, Szabo C, Curi R, de Lima-Salgado TM, Soriano FG. Gene expression reprogramming protects macrophage from septic-induced cell death. Molecular Immunology. 47: 2587-93. PMID 20728938 DOI: 10.1016/J.Molimm.2010.06.011 | 0.303 | |||
| 2010 | Roberts RA, Smith RA, Safe S, Szabo C, Tjalkens RB, Robertson FM. Toxicological and pathophysiological roles of reactive oxygen and nitrogen species. Toxicology. 276: 85-94. PMID 20643181 DOI: 10.1016/J.Tox.2010.07.009 | 0.338 | |||
| 2010 | Szabó C, Módis K. Pathophysiological roles of peroxynitrite in circulatory shock. Shock (Augusta, Ga.). 34: 4-14. PMID 20523270 DOI: 10.1097/Shk.0B013E3181E7E9Ba | 0.695 | |||
| 2010 | Lorigados CB, Soriano FG, Szabo C. Pathomechanisms of myocardial dysfunction in sepsis. Endocrine, Metabolic & Immune Disorders Drug Targets. 10: 274-84. PMID 20509838 DOI: 10.2174/187153010791936856 | 0.324 | |||
| 2010 | Roesner JP, Mersmann J, Bergt S, Bohnenberg K, Barthuber C, Szabo C, Nöldge-Schomburg GE, Zacharowski K. Therapeutic injection of PARP inhibitor INO-1001 preserves cardiac function in porcine myocardial ischemia and reperfusion without reducing infarct size. Shock (Augusta, Ga.). 33: 507-12. PMID 20395771 DOI: 10.1097/Shk.0B013E3181C4Fb08 | 0.303 | |||
| 2010 | Ózsvári B, Puskás LG, Nagy LI, Kanizsai I, Gyuris M, Madácsi R, Fehér LZ, Gerö D, Szabó C. A cell-microelectronic sensing technique for the screening of cytoprotective compounds International Journal of Molecular Medicine. 25: 525-530. PMID 20198300 DOI: 10.3892/Ijmm-00000373 | 0.334 | |||
| 2010 | Osipov RM, Robich MP, Feng J, Chan V, Clements RT, Deyo RJ, Szabo C, Sellke FW. Effect of hydrogen sulfide on myocardial protection in the setting of cardioplegia and cardiopulmonary bypass. Interactive Cardiovascular and Thoracic Surgery. 10: 506-12. PMID 20051450 DOI: 10.1510/Icvts.2009.219535 | 0.329 | |||
| 2010 | Saunders FD, Westphal M, Enkhbaatar P, Wang J, Pazdrak K, Nakano Y, Hamahata A, Jonkam CC, Lange M, Connelly RL, Kulp GA, Cox RA, Hawkins HK, Schmalstieg FC, Horvath E, ... Szabo C, et al. Molecular biological effects of selective neuronal nitric oxide synthase inhibition in ovine lung injury. American Journal of Physiology. Lung Cellular and Molecular Physiology. 298: L427-36. PMID 19965980 DOI: 10.1152/Ajplung.00147.2009 | 0.349 | |||
| 2010 | Melo ES, Goloubkova T, Barbeiro DF, Gorjão R, Vasconcelos D, Szabo C, Curi R, de Lima Salgado TM, Velasco IT, Soriano FG. Endotoxin tolerance: selective alterations in gene expression and protection against lymphocyte death. Immunobiology. 215: 435-42. PMID 19800145 DOI: 10.1016/J.Imbio.2009.09.002 | 0.315 | |||
| 2010 | Wagner F, Simon F, Scheuerle A, Groeger M, Calzia E, Soell A, McCook O, Stahl B, Speit G, Georgieff M, Radermacher P, Szabo C, Schelzig H. Effect of intravenous H2S on porcine aortic occlusion-induced systemic inflammation and kidney ischemia/reperfusion injury Critical Care. 14: 507. DOI: 10.1186/Cc8739 | 0.322 | |||
| 2010 | Groeger M, Wagner F, Baumgart K, Huber-Lang M, Knoeferl M, Georgieff M, Radermacher P, Szabo C, Calzia E. Mitochondrial respiration and cytochrome c inhibition by sulfide in peritoneal macrophages in vitro : effects of temperature and pH Critical Care. 14: 6. DOI: 10.1186/Cc8238 | 0.343 | |||
| 2010 | Baumgart K, Wagner F, Hysa V, Vogt J, Wachter U, Weber S, Georgieff M, Radermacher P, Szabo C, Calzia E. Effects of temperature and H2S inhalation on glucose metabolism in murine resuscitated septic shock Critical Care. 14: 5. DOI: 10.1186/Cc8237 | 0.301 | |||
| 2010 | Bracht H, Simon F, Hauser B, Groeger M, Soell A, McCook O, Georgieff M, Radermacher P, Szabo C, Calzia E. Time-dependent effects of intravenous H2S during long-term, resuscitated porcine hemorrhagic shock Critical Care. 14: 3. DOI: 10.1186/Cc8235 | 0.331 | |||
| 2010 | Szabo C. Medicinal Chemistry and Therapeutic Applications of the Gasotransmitters NO, CO, and H2S and their Prodrugs Burger's Medicinal Chemistry and Drug Discovery. 265-368. DOI: 10.1002/0471266949.Bmc178 | 0.346 | |||
| 2009 | Papapetropoulos A, Pyriochou A, Altaany Z, Yang G, Marazioti A, Zhou Z, Jeschke MG, Branski LK, Herndon DN, Wang R, Szabó C. Hydrogen sulfide is an endogenous stimulator of angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 106: 21972-7. PMID 19955410 DOI: 10.1073/Pnas.0908047106 | 0.354 | |||
| 2009 | Módis K, Gero D, Nagy N, Szoleczky P, Tóth ZD, Szabó C. Cytoprotective effects of adenosine and inosine in an in vitro model of acute tubular necrosis. British Journal of Pharmacology. 158: 1565-78. PMID 19906119 DOI: 10.1111/J.1476-5381.2009.00432.X | 0.644 | |||
| 2009 | Esechie A, Enkhbaatar P, Traber DL, Jonkam C, Lange M, Hamahata A, Djukom C, Whorton EB, Hawkins HK, Traber LD, Szabo C. Beneficial effect of a hydrogen sulphide donor (sodium sulphide) in an ovine model of burn- and smoke-induced acute lung injury. British Journal of Pharmacology. 158: 1442-53. PMID 19845680 DOI: 10.1111/J.1476-5381.2009.00411.X | 0.336 | |||
| 2009 | Sodha NR, Clements RT, Feng J, Liu Y, Bianchi C, Horvath EM, Szabo C, Stahl GL, Sellke FW. Hydrogen sulfide therapy attenuates the inflammatory response in a porcine model of myocardial ischemia/reperfusion injury. The Journal of Thoracic and Cardiovascular Surgery. 138: 977-84. PMID 19660398 DOI: 10.1016/J.Jtcvs.2008.08.074 | 0.312 | |||
| 2009 | Osipov RM, Robich MP, Feng J, Liu Y, Clements RT, Glazer HP, Sodha NR, Szabo C, Bianchi C, Sellke FW. Effect of hydrogen sulfide in a porcine model of myocardial ischemia-reperfusion: comparison of different administration regimens and characterization of the cellular mechanisms of protection. Journal of Cardiovascular Pharmacology. 54: 287-97. PMID 19620880 DOI: 10.1097/Fjc.0B013E3181B2B72B | 0.317 | |||
| 2009 | Cai B, Chen F, Ji Y, Kiss L, de Jonge WJ, Conejero-Goldberg C, Szabo C, Deitch EA, Ulloa L. Alpha7 cholinergic-agonist prevents systemic inflammation and improves survival during resuscitation. Journal of Cellular and Molecular Medicine. 13: 3774-85. PMID 19602049 DOI: 10.1111/J.1582-4934.2008.00550.X | 0.302 | |||
| 2009 | Wagner F, Asfar P, Calzia E, Radermacher P, Szabó C. Bench-to-bedside review: Hydrogen sulfide--the third gaseous transmitter: applications for critical care. Critical Care. 13: 213-213. PMID 19519960 DOI: 10.1186/Cc7700 | 0.359 | |||
| 2009 | Pankotai E, Lacza Z, Murányi M, Szabó C. Intra-mitochondrial poly(ADP-ribosyl)ation: potential role for alpha-ketoglutarate dehydrogenase. Mitochondrion. 9: 159-64. PMID 19460292 DOI: 10.1016/J.Mito.2009.01.013 | 0.346 | |||
| 2009 | Insko MA, Deckwerth TL, Hill P, Toombs CF, Szabo C. Detection of exhaled hydrogen sulphide gas in rats exposed to intravenous sodium sulphide British Journal of Pharmacology. 157: 944-951. PMID 19422378 DOI: 10.1111/J.1476-5381.2009.00248.X | 0.312 | |||
| 2009 | Mukhopadhyay P, Rajesh M, Bátkai S, Kashiwaya Y, Haskó G, Liaudet L, Szabó C, Pacher P. Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro American Journal of Physiology-Heart and Circulatory Physiology. 296. PMID 19286953 DOI: 10.1152/Ajpheart.00795.2008 | 0.344 | |||
| 2009 | Szabo C. Role of nitrosative stress in the pathogenesis of diabetic vascular dysfunction: REVIEW British Journal of Pharmacology. 156: 713-727. PMID 19210748 DOI: 10.1111/J.1476-5381.2008.00086.X | 0.382 | |||
| 2009 | Mabley JG, Pacher P, Szabo C. Activation of the cholinergic antiinflammatory pathway reduces ricin-induced mortality and organ failure in mice Molecular Medicine. 15: 166-172. PMID 19209239 DOI: 10.2119/Molmed.2008.00105 | 0.318 | |||
| 2009 | Rajesh M, Mukhopadhyay P, Bátkai S, Mukhopadhyay B, Patel V, Haskó G, Szabó C, Mabley JG, Liaudet L, Pacher P. Xanthine oxidase inhibitor allopurinol attenuates the development of diabetic cardiomyopathy. Journal of Cellular and Molecular Medicine. 13: 2330-41. PMID 19175688 DOI: 10.1111/J.1582-4934.2008.00564.X | 0.321 | |||
| 2009 | Mabley JG, Pacher P, Murthy KG, Williams W, Southan GJ, Salzman AL, Szabo C. The novel inosine analogue INO-2002 exerts an anti-inflammatory effect in a murine model of acute lung injury. Shock (Augusta, Ga.). 32: 258-62. PMID 19174745 DOI: 10.1097/Shk.0B013E31819C3414 | 0.321 | |||
| 2009 | Enkhbaatar P, Connelly R, Wang J, Nakano Y, Lange M, Hamahata A, Horvath E, Szabo C, Jaroch S, Hölscher P, Hillmann M, Traber LD, Schmalstieg FC, Herndon DN, Traber DL. Inhibition of neuronal nitric oxide synthase in ovine model of acute lung injury. Critical Care Medicine. 37: 208-14. PMID 19050603 DOI: 10.1097/Ccm.0B013E318193226A | 0.304 | |||
| 2008 | Maybauer DM, Maybauer MO, Szabó C, Westphal M, Traber LD, Enkhbaatar P, Murthy KGK, Nakano Y, Salzman AL, Herndon DN, Traber DL. Lung-protective effects of the metalloporphyrinic peroxynitrite decomposition catalyst WW-85 in interleukin-2 induced toxicity. Biochemical and Biophysical Research Communications. 377: 786-791. PMID 18951875 DOI: 10.1016/J.Bbrc.2008.10.066 | 0.32 | |||
| 2008 | Radovits T, Gerö D, Lin LN, Loganathan S, Hoppe-Tichy T, Szabó C, Karck M, Sakurai H, Szabó G. Improvement of aging-associated cardiovascular dysfunction by the orally administered copper(II)-aspirinate complex. Rejuvenation Research. 11: 945-56. PMID 18922047 DOI: 10.1089/Rej.2008.0762 | 0.319 | |||
| 2008 | Kiss L, Deitch EA, Szabó C. Hydrogen sulfide decreases adenosine triphosphate levels in aortic rings and leads to vasorelaxation via metabolic inhibition Life Sciences. 83: 589-594. PMID 18790700 DOI: 10.1016/J.Lfs.2008.08.006 | 0.366 | |||
| 2008 | Pacher P, Szabo C. Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease American Journal of Pathology. 173: 2-13. PMID 18535182 DOI: 10.2353/Ajpath.2008.080019 | 0.375 | |||
| 2008 | Gero D, Szabo C. Poly(ADP-ribose) polymerase: A new therapeutic target? Current Opinion in Anaesthesiology. 21: 111-121. PMID 18443476 DOI: 10.1097/Aco.0B013E3282F63C15 | 0.355 | |||
| 2008 | Hegedus C, Lakatos P, Oláh G, Tóth BI, Gergely S, Szabó E, Bíró T, Szabó C, Virág L. Protein kinase C protects from DNA damage-induced necrotic cell death by inhibiting poly(ADP-ribose) polymerase-1. Febs Letters. 582: 1672-8. PMID 18439913 DOI: 10.1016/J.Febslet.2008.04.023 | 0.334 | |||
| 2008 | Westphal M, Enkhbaatar P, Schmalstieg FC, Kulp GA, Traber LD, Morita N, Cox RA, Hawkins HK, Westphal-Varghese BB, Rudloff HE, Maybauer DM, Maybauer MO, Burke AS, Murakami K, Saunders F, ... ... Szabo C, et al. Neuronal nitric oxide synthase inhibition attenuates cardiopulmonary dysfunctions after combined burn and smoke inhalation injury in sheep. Critical Care Medicine. 36: 1196-204. PMID 18379246 DOI: 10.1097/Ccm.0B013E31816A1A0C | 0.317 | |||
| 2008 | Simon F, Giudici R, Duy CN, Schelzig H, Öter S, Gröger M, Wachter U, Vogt J, Speit G, Szabo C, Radermacher P, Calzia E. Hemodynamic And Metabolic Effects Of Hydrogen Sulfide During Porcine Ischemia/Reperfusion Injury Shock. 30: 359-364. PMID 18323742 DOI: 10.1097/Shk.0B013E3181674185 | 0.314 | |||
| 2008 | Esechie A, Kiss L, Olah G, Horváth EM, Hawkins H, Szabo C, Traber DL. Protective effect of hydrogen sulfide in a murine model of acute lung injury induced by combined burn and smoke inhalation. Clinical Science (London, England : 1979). 115: 91-7. PMID 18315525 DOI: 10.1042/Cs20080021 | 0.368 | |||
| 2008 | Sodha NR, Clements RT, Feng J, Liu Y, Bianchi C, Horvath EM, Szabo C, Sellke FW. The effects of therapeutic sulfide on myocardial apoptosis in response to ischemia-reperfusion injury. European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association For Cardio-Thoracic Surgery. 33: 906-13. PMID 18314343 DOI: 10.1016/J.Ejcts.2008.01.047 | 0.323 | |||
| 2008 | McCourtie AS, Farivar AS, Woolley SM, Merry HE, Wolf PS, Szabo C, Mulligan MS. Poly (ADP) ribose synthetase inhibition in alveolar macrophages undergoing hypoxia and reoxygenation. Experimental and Molecular Pathology. 84: 141-4. PMID 18206870 DOI: 10.1016/J.Yexmp.2007.11.005 | 0.396 | |||
| 2008 | Horváth EM, Benko R, Gero D, Kiss L, Szabó C. Treatment with insulin inhibits poly(ADP-ribose)polymerase activation in a rat model of endotoxemia Life Sciences. 82: 205-209. PMID 18078960 DOI: 10.1016/J.Lfs.2007.11.001 | 0.324 | |||
| 2008 | Lai Y, Chen Y, Watkins SC, Nathaniel PD, Guo F, Kochanek PM, Jenkins LW, Szabó C, Clark RS. Identification of poly-ADP-ribosylated mitochondrial proteins after traumatic brain injury. Journal of Neurochemistry. 104: 1700-11. PMID 17996029 DOI: 10.1111/J.1471-4159.2007.05114.X | 0.337 | |||
| 2008 | Pyriochou A, Olah G, Deitch EA, Szabó C, Papapetropoulos A. Inhibition of angiogenesis by the poly(ADP-ribose) polymerase inhibitor PJ-34. International Journal of Molecular Medicine. 22: 113-118. DOI: 10.3892/Ijmm.22.1.113 | 0.336 | |||
| 2007 | Szabó C. Hydrogen Sulphide and Its Therapeutic Potential Nature Reviews Drug Discovery. 6: 917-935. PMID 17948022 DOI: 10.1038/Nrd2425 | 0.339 | |||
| 2007 | Pacher P, Szabó C. Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors. Cardiovascular Drug Reviews. 25: 235-260. PMID 17919258 DOI: 10.1111/J.1527-3466.2007.00018.X | 0.386 | |||
| 2007 | Gerö D, Módis K, Nagy N, Szoleczky P, Tóth ZD, Dormán G, Szabó C. Oxidant-induced cardiomyocyte injury: identification of the cytoprotective effect of a dopamine 1 receptor agonist using a cell-based high-throughput assay. International Journal of Molecular Medicine. 20: 749-61. PMID 17912470 | 0.661 | |||
| 2007 | Radovits T, Zotkina J, Lin LN, Bömicke T, Arif R, Gero D, Horváth EM, Karck M, Szabo C, Szabó G. Poly(ADP-Ribose) polymerase inhibition improves endothelial dysfunction induced by hypochlorite. Experimental Biology and Medicine. 232: 1204-1212. PMID 17895528 DOI: 10.3181/0701-Rm-16 | 0.39 | |||
| 2007 | Elrod JW, Calvert JW, Morrison J, Doeller JE, Kraus DW, Tao L, Jiao X, Scalia R, Kiss L, Szabo C, Kimura H, Chow CW, Lefer DJ. Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function. Proceedings of the National Academy of Sciences of the United States of America. 104: 15560-5. PMID 17878306 DOI: 10.1073/Pnas.0705891104 | 0.353 | |||
| 2007 | Clark RS, Vagni VA, Nathaniel PD, Jenkins LW, Dixon CE, Szabó C. Local administration of the poly(ADP-ribose) polymerase inhibitor INO-1001 prevents NAD+ depletion and improves water maze performance after traumatic brain injury in mice. Journal of Neurotrauma. 24: 1399-405. PMID 17711401 DOI: 10.1089/Neu.2007.0305 | 0.327 | |||
| 2007 | Szabó C, Ischiropoulos H, Radi R. Peroxynitrite: biochemistry, pathophysiology and development of therapeutics. Nature Reviews. Drug Discovery. 6: 662-80. PMID 17667957 DOI: 10.1038/Nrd2222 | 0.355 | |||
| 2007 | Szijártó A, Batmunkh E, Hahn O, Mihály Z, Kreiss A, Kiss A, Lotz G, Schaff Z, Váli L, Blázovics A, Geró D, Szabó C, Kupcsulik P. Effect of PJ-34 PARP-inhibitor on rat liver microcirculation and antioxidant status. The Journal of Surgical Research. 142: 72-80. PMID 17612561 DOI: 10.1016/J.Jss.2006.08.003 | 0.332 | |||
| 2007 | Horváth EM, Szabo C. Poly(ADP-ribose) polymerase as a drug target for cardiovascular disease and cancer: an update. Drug News & Perspectives. 20: 171-181. PMID 17520094 DOI: 10.1358/Dnp.2007.20.3.1092098 | 0.355 | |||
| 2007 | Bai P, Hegedus C, Erdélyi K, Szabó É, Bakondi E, Gergely S, Szabo C, Virág L. Protein tyrosine nitration and poly(ADP-ribose) polymerase activation in N-methyl-N-nitro-N-nitrosoguanidine-treated thymocytes: implication for cytotoxicity. Toxicology Letters. 170: 203-213. PMID 17428624 DOI: 10.1016/J.Toxlet.2007.03.007 | 0.34 | |||
| 2007 | Radovits T, Lin Ln, Zotkina J, Gero D, Szabó C, Karck M, Szabó G. Poly(ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by reactive oxidant hydrogen peroxide in vitro European Journal of Pharmacology. 564: 158-166. PMID 17397824 DOI: 10.1016/J.Ejphar.2007.02.060 | 0.381 | |||
| 2007 | Radovits T, Seres L, Gero D, Berger I, Szabo C, Karck M, Szabó G. Single dose treatment with PARP-inhibitor INO-1001 improves aging-associated cardiac and vascular dysfunction. Experimental Gerontology. 42: 676-685. PMID 17383839 DOI: 10.1016/J.Exger.2007.01.013 | 0.344 | |||
| 2007 | Seabra AB, Pankotai E, Fehér M, Somlai A, Kiss L, Bíró L, Szabó C, Kollai M, de Oliveira MG, Lacza Z. S-nitrosoglutathione-containing hydrogel increases dermal blood flow in streptozotocin-induced diabetic rats. The British Journal of Dermatology. 156: 814-8. PMID 17263816 DOI: 10.1111/J.1365-2133.2006.07718.X | 0.318 | |||
| 2007 | Lenzsér G, Kis B, Snipes JA, Gáspár T, Sándor P, Komjáti K, Szabó C, Busija DW. Contribution of poly(ADP-ribose) polymerase to postischemic blood-brain barrier damage in rats. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 27: 1318-26. PMID 17213862 DOI: 10.1038/Sj.Jcbfm.9600437 | 0.352 | |||
| 2007 | Radovits T, Seres L, Gero D, Lin LN, Beller CJ, Chen SH, Zotkina J, Berger I, Groves JT, Szabó C, Szabó G. The peroxynitrite decomposition catalyst FP15 improves ageing-associated cardiac and vascular dysfunction. Mechanisms of Ageing and Development. 128: 173-81. PMID 17116320 DOI: 10.1016/J.Mad.2006.09.005 | 0.32 | |||
| 2007 | Csordás A, Pankotai E, Snipes JA, Cselenyák A, Sárszegi Z, Cziráki A, Gaszner B, Papp L, Benko R, Kiss L, Kovács E, Kollai M, Szabó C, Busija DW, Lacza Z. Human heart mitochondria do not produce physiologically relevant quantities of nitric oxide. Life Sciences. 80: 633-7. PMID 17113604 DOI: 10.1016/J.Lfs.2006.10.009 | 0.327 | |||
| 2007 | Beller CJ, Horvath E, Kosse J, Becker A, Radovits T, Krempien R, Berger I, Hagl S, Szabó C, Szabó G. Opposite effects of vascular irradiation on inflammatory response and apoptosis induction in the vessel wall layers via the peroxynitrite-poly(ADP-ribose) polymerase pathway. Clinical Research in Cardiology. 96: 8-16. PMID 17021679 DOI: 10.1007/S00392-006-0446-Z | 0.324 | |||
| 2007 | Quagliaro L, Piconi L, Assaloni R, Ros RD, Szabó C, Ceriello A. Primary role of superoxide anion generation in the cascade of events leading to endothelial dysfunction and damage in high glucose treated HUVEC. Nutrition Metabolism and Cardiovascular Diseases. 17: 257-267. PMID 16891102 DOI: 10.1016/J.Numecd.2006.01.007 | 0.355 | |||
| 2007 | Gerö D, Módis K, Nagy N, Szoleczky P, Tóth ZD, Dormán G, Szabó C. Oxidant-induced cardiomyocyte injury : Identification of the cytoprotective effect of a dopamine 1 receptor agonist using a cell-based high-throughput assay International Journal of Molecular Medicine. 20: 749-761. DOI: 10.3892/Ijmm.20.5.749 | 0.688 | |||
| 2007 | Szabo C, Horvath E, Benko R, Gero D. Insulin therapy inhibits poly(ADP-ribose)polymerase activation in endotoxin shock Critical Care. 11: 123. DOI: 10.1186/Cc5283 | 0.337 | |||
| 2007 | Saunders F, Westphal M, Enkhbaatar P, Wang J, Gonzalez M, Nakano Y, Hamahata A, Jonkam C, Connelly R, Cox R, Hawkins H, Schmalstieg F, Horvath E, Lange M, Szabo C, et al. Effects of neuronal nitric oxide synthase in ovine lung injury Critical Care. 11: 16. DOI: 10.1186/Cc5176 | 0.315 | |||
| 2007 | Szabo C, Kiss L, Pankotai E. Cytoprotective and anti-inflammatory effects of hydrogen sulfide in macrophages and mice Critical Care. 11: 2. DOI: 10.1186/Cc5162 | 0.375 | |||
| 2007 | Saunders F, Lange M, Szabo C, Westphal M, Traber DL. Inhibition of neuronal nitric oxide syhnthase with 7-nitroindazole attenuates oxidative stress after combined burn and smoke injury in sheep: 4AP8-9 European Journal of Anaesthesiology. 24: 54. DOI: 10.1097/00003643-200706001-00199 | 0.302 | |||
| 2007 | Szabo C. Poly (ADP-ribose) polymerase activation and circulatory shock. Novartis Foundation Symposium. 280: 92-107. DOI: 10.1002/9780470059593.Ch7 | 0.384 | |||
| 2006 | Tóth-Zsámboki E, Horváth E, Vargova K, Pankotai E, Murthy K, Zsengellér Z, Bárány T, Pék T, Fekete K, Kiss RG, Préda I, Lacza Z, Gerö D, Szabó C. Activation of poly(ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes. Molecular Medicine (Cambridge, Mass.). 12: 221-8. PMID 17225870 DOI: 10.2119/2006-00055.Toth-Zsamboki | 0.339 | |||
| 2006 | Kiss L, Chen M, Gero D, Módis K, Lacza Z, Szabó C. Effects of 7-ketocholesterol on the activity of endothelial poly(ADP-ribose) polymerase and on endothelium-dependent relaxant function. International Journal of Molecular Medicine. 18: 1113-7. PMID 17089016 | 0.644 | |||
| 2006 | Szabo C, Pacher P, Swanson RA. Novel modulators of poly(ADP-ribose) polymerase. Trends in Pharmacological Sciences. 27: 626-30. PMID 17055069 DOI: 10.1016/J.Tips.2006.10.003 | 0.321 | |||
| 2006 | Beller CJ, Kosse J, Radovits T, Gerö D, Krempien R, Gross ML, Berger I, Hagl S, Szabó C, Szabó G. Poly(ADP-ribose) polymerase inhibition combined with irradiation: A dual treatment concept to prevent neointimal hyperplasia after endarterectomy International Journal of Radiation Oncology Biology Physics. 66: 867-875. PMID 17011459 DOI: 10.1016/J.Ijrobp.2006.06.055 | 0.313 | |||
| 2006 | Gero D, Szabó C. Role of the peroxynitrite-poly (ADP-ribose) polymerase pathway in the pathogenesis of liver injury. Current Pharmaceutical Design. 12: 2903-2910. PMID 16918420 DOI: 10.2174/138161206777947579 | 0.36 | |||
| 2006 | Haddad M, Rhinn H, Bloquel C, Coqueran B, Szabo C, Plotkine M, Scherman D, Margaill I. Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice British Journal of Pharmacology. 149: 23-30. PMID 16865091 DOI: 10.1038/Sj.Bjp.0706837 | 0.335 | |||
| 2006 | Beller CJ, Radovits T, Seres L, Kosse J, Krempien R, Gross ML, Penzel R, Berger I, Huber PE, Hagl S, Szabó C, Szabó G. Poly(ADP-ribose) polymerase inhibition reverses vascular dysfunction after γ-irradiation International Journal of Radiation Oncology Biology Physics. 65: 1528-1535. PMID 16863929 DOI: 10.1016/J.Ijrobp.2006.03.058 | 0.32 | |||
| 2006 | Szabó G, Bährle S, Sivanandam V, Stumpf N, Gerö D, Berger I, Beller C, Hagl S, Szabó C, Dengler TJ. Immunomodulatory Effects of Poly(ADP-ribose) Polymerase Inhibition Contribute to Improved Cardiac Function and Survival During Acute Cardiac Rejection Journal of Heart and Lung Transplantation. 25: 794-804. PMID 16818122 DOI: 10.1016/J.Healun.2006.03.017 | 0.336 | |||
| 2006 | Szabó G, Stumpf N, Radovits T, Sonnenberg K, Gerö D, Hagl S, Szabó C, Bährle S. Effects of inosine on reperfusion injury after heart transplantation European Journal of Cardio-Thoracic Surgery. 30: 96-102. PMID 16730445 DOI: 10.1016/J.Ejcts.2006.04.003 | 0.308 | |||
| 2006 | Hauser B, Gröger M, Ehrmann U, Albicini M, Brückner UB, Schelzig H, Venkatesh B, Li H, Szabó C, Speit G, Radermacher P, Kick J. The parp-1 inhibitor ino-1001 facilitates hemodynamic stabilization without affecting DNA repair in porcine thoracic aortic cross-clamping-induced ischemia/reperfusion. Shock (Augusta, Ga.). 25: 633-40. PMID 16721272 DOI: 10.1097/01.Shk.0000209561.61951.2E | 0.346 | |||
| 2006 | Beller CJ, Radovits T, Kosse J, Gerö D, Szabó C, Szabó G. Activation of the peroxynitrite-poly(adenosine diphosphate-ribose) polymerase pathway during neointima proliferation: A new target to prevent restenosis after endarterectomy Journal of Vascular Surgery. 43: 824-830. PMID 16616243 DOI: 10.1016/J.Jvs.2005.11.021 | 0.314 | |||
| 2006 | Lacza Z, Kozlov AV, Pankotai E, Csordás A, Wolf G, Redl H, Kollai M, Szabó C, Busija DW, Horn TF. Mitochondria produce reactive nitrogen species via an arginine-independent pathway. Free Radical Research. 40: 369-78. PMID 16517501 DOI: 10.1080/10715760500539139 | 0.345 | |||
| 2006 | Paquette DW, Rosenberg A, Lohinai Z, Southan GJ, Williams RC, Offenbacher S, Szabó C. Inhibition of experimental gingivitis in beagle dogs with topical mercaptoalkylguanidines. Journal of Periodontology. 77: 385-91. PMID 16512752 DOI: 10.1902/Jop.2006.050049 | 0.356 | |||
| 2006 | Pacher P, Nivorozhkin A, Szabó C. Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol Pharmacological Reviews. 58: 87-114. PMID 16507884 DOI: 10.1124/Pr.58.1.6 | 0.327 | |||
| 2006 | Pacher P, Szabó C. Role of peroxynitrite in the pathogenesis of cardiovascular complications of diabetes Current Opinion in Pharmacology. 6: 136-141. PMID 16483848 DOI: 10.1016/J.Coph.2006.01.001 | 0.303 | |||
| 2006 | Tóth O, Szabó C, Kecskés M, Pótó L, Nagy Á, Losonczy H. In vitro effect of the potent poly(ADP-ribose) polymerase (PARP) inhibitor INO-1001 alone and in combination with aspirin, eptifibatide, tirofiban, enoxaparin or alteplase on haemostatic parameters. Life Sciences. 79: 317-323. PMID 16480745 DOI: 10.1016/J.Lfs.2006.01.007 | 0.323 | |||
| 2006 | Szabó C. Poly(ADP-ribose) polymerase activation by reactive nitrogen species--relevance for the pathogenesis of inflammation. Nitric Oxide. 14: 169-179. PMID 16111903 DOI: 10.1016/J.Niox.2005.06.008 | 0.365 | |||
| 2006 | Lacza Z, Pankotai E, Csordás A, Gero D, Kiss L, Horváth EM, Kollai M, Busija DW, Szabó C. Mitochondrial NO and reactive nitrogen species production: does mtNOS exist? Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 14: 162-8. PMID 16051505 DOI: 10.1016/J.Niox.2005.05.011 | 0.326 | |||
| 2006 | Kiss L, Chen M, Gero D, Módis K, Lacza Z, Szabó C. Effects of 7-ketocholesterol on the activity of endothelial poly(ADP-ribose) polymerase and on endothelium-dependent relaxant function International Journal of Molecular Medicine. 18: 1113-1117. DOI: 10.3892/Ijmm.18.6.1113 | 0.672 | |||
| 2006 | Pacher P, Liaudet L, Mabley JG, Cziráki A, Haskó G, Szabó C. Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure. International Journal of Molecular Medicine. 17: 369-375. DOI: 10.3892/Ijmm.17.2.369 | 0.318 | |||
| 2005 | Pacher P, Szabó C. Role of Poly(ADP-Ribose) Polymerase-1 Activation in the Pathogenesis of Diabetic Complications: Endothelial Dysfunction, as a Common Underlying Theme Antioxidants & Redox Signaling. 7: 1568-1580. PMID 16356120 DOI: 10.1089/Ars.2005.7.1568 | 0.361 | |||
| 2005 | Kendirci M, Zsengellér Z, Bivalacqua TJ, Gur S, Usta MF, Chen M, Szabó C, Hellstrom WJG. Poly(adenosine diphosphate-ribose) polymerase inhibition preserves erectile function in rats after cavernous nerve injury Journal of Urology. 174: 2054-2059. PMID 16217393 DOI: 10.1097/01.Ju.0000176484.35636.E5 | 0.3 | |||
| 2005 | Mabley JG, Horváth EM, Murthy KG, Zsengellér Z, Vaslin A, Benko R, Kollai M, Szabó C. Gender differences in the endotoxin-induced inflammatory and vascular responses: potential role of poly(ADP-ribose) polymerase activation. The Journal of Pharmacology and Experimental Therapeutics. 315: 812-20. PMID 16079296 DOI: 10.1124/Jpet.105.090480 | 0.322 | |||
| 2005 | Szabo C. Pharmacological inhibition of poly(ADP-ribose) polymerase in cardiovascular disorders: future directions. Current Vascular Pharmacology. 3: 301-303. PMID 16026326 DOI: 10.2174/1570161054368553 | 0.327 | |||
| 2005 | Erdèlyi K, Kiss A, Bakondi E, Bai P, Szabó C, Gergely P, Erdodi F, Virág L. Gallotannin inhibits the expression of chemokines and inflammatory cytokines in A549 cells Molecular Pharmacology. 68: 895-904. PMID 15976037 DOI: 10.1124/Mol.105.012518 | 0.327 | |||
| 2005 | Kiss L, Szabó C. The pathogenesis of diabetic complications: the role of DNA injury and poly(ADP-ribose) polymerase activation in peroxynitrite-mediated cytotoxicity Memorias Do Instituto Oswaldo Cruz. 100: 29-37. PMID 15962096 DOI: 10.1590/S0074-02762005000900007 | 0.34 | |||
| 2005 | Pacher P, Schulz R, Liaudet L, Szabó C. Nitrosative stress and pharmacological modulation of heart failure Trends in Pharmacological Sciences. 26: 302-310. PMID 15925705 DOI: 10.1016/J.Tips.2005.04.003 | 0.321 | |||
| 2005 | Graziani G, Szabó C. Clinical perspectives of PARP inhibitors Pharmacological Research. 52: 109-118. PMID 15911339 DOI: 10.1016/J.Phrs.2005.02.013 | 0.32 | |||
| 2005 | Szabó C. Roles of poly(ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and its complications Pharmacological Research. 52: 60-71. PMID 15911334 DOI: 10.1016/J.Phrs.2005.02.015 | 0.308 | |||
| 2005 | Szabó C. Cardioprotective effects of poly(ADP-ribose) polymerase inhibition. Pharmacological Research. 52: 34-43. PMID 15911332 DOI: 10.1016/J.Phrs.2005.02.017 | 0.362 | |||
| 2005 | Erdélyi K, Bakondi E, Gergely P, Szabo C, Virág L. Pathophysiologic role of oxidative stress-induced poly(ADP-ribose) polymerase-1 activation: Focus on cell death and transcriptional regulation Cellular and Molecular Life Sciences. 62: 751-759. PMID 15868400 DOI: 10.1007/S00018-004-4506-0 | 0.381 | |||
| 2005 | Jagtap P, Szabo C. Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors Nature Reviews Drug Discovery. 4: 421-440. PMID 15864271 DOI: 10.1038/Nrd1718 | 0.354 | |||
| 2005 | Komjáti K, Besson VC, Szabo C. Poly (adp-ribose) polymerase inhibitors as potential therapeutic agents in stroke and neurotrauma. Current Drug Targets - Cns & Neurological Disorders. 4: 179-194. PMID 15857303 DOI: 10.2174/1568007053544138 | 0.323 | |||
| 2005 | Li F, Drel VR, Szabó C, Stevens MJ, Obrosova IG. Low-dose poly(ADP-ribose) polymerase inhibitor-containing combination therapies reverse early peripheral diabetic neuropathy. Diabetes. 54: 1514-22. PMID 15855340 DOI: 10.2337/Diabetes.54.5.1514 | 0.305 | |||
| 2005 | Besson VC, Zsengellér Z, Plotkine M, Szabó C, Marchand-Verrecchia C. Beneficial effects of PJ34 and INO-1001, two novel water-soluble poly(ADP-ribose) polymerase inhibitors, on the consequences of traumatic brain injury in rat. Brain Research. 1041: 149-156. PMID 15829224 DOI: 10.1016/J.Brainres.2005.01.096 | 0.319 | |||
| 2005 | Crocker IP, Kenny LC, Thornton WA, Szabo C, Baker PN. Excessive stimulation of poly(ADP-ribosyl)ation contributes to endothelial dysfunction in pre-eclampsia. British Journal of Pharmacology. 144: 772-80. PMID 15778700 DOI: 10.1038/Sj.Bjp.0706055 | 0.383 | |||
| 2005 | Pacher P, Obrosova IG, Mabley JG, Szabo C. Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies. Current Medicinal Chemistry. 12: 267-275. PMID 15723618 DOI: 10.2174/0929867053363207 | 0.303 | |||
| 2005 | Szenczi O, Kemecsei P, Holthuijsen MF, van Riel NA, van der Vusse GJ, Pacher P, Szabó C, Kollai M, Ligeti L, Ivanics T. Poly(ADP-ribose) polymerase regulates myocardial calcium handling in doxorubicin-induced heart failure. Biochemical Pharmacology. 69: 725-32. PMID 15710350 DOI: 10.1016/J.Bcp.2004.11.023 | 0.329 | |||
| 2005 | Szabó G, Soós P, Heger U, Flechtenmacher C, Bährle S, Zsengellér Z, Szabó C, Hagl S. Poly(ADP-ribose) polymerase inhibition attenuates biventricular reperfusion injury after orthotopic heart transplantation European Journal of Cardio-Thoracic Surgery. 27: 226-234. PMID 15691675 DOI: 10.1016/J.Ejcts.2004.10.055 | 0.322 | |||
| 2005 | Mabley JG, Pacher P, Deb A, Wallace R, Elder RH, Szabó C. Potential role for 8-oxoguanine DNA glycosylase in regulating inflammation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 290-2. PMID 15677345 DOI: 10.1096/Fj.04-2278Fje | 0.317 | |||
| 2005 | Obrosova IG, Pacher P, Szabó C, Zsengeller Z, Hirooka H, Stevens MJ, Yorek MA. Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications. Diabetes. 54: 234-42. PMID 15616034 DOI: 10.2337/Diabetes.54.1.234 | 0.319 | |||
| 2005 | Xiao CY, Chen M, Zsengellér Z, Li H, Kiss L, Kollai M, Szabó C. Poly(ADP-Ribose) polymerase promotes cardiac remodeling, contractile failure, and translocation of apoptosis-inducing factor in a murine experimental model of aortic banding and heart failure. The Journal of Pharmacology and Experimental Therapeutics. 312: 891-8. PMID 15523000 DOI: 10.1124/Jpet.104.077164 | 0.337 | |||
| 2005 | Hauser B, Ehrmann U, Albicini M, Gröger M, Radermacher P, Szabó C, Kick J. Selective poly(ADP-ribose)-polymerase inhibition affects neither DNA repair nor cell senescence after ischemia-reperfusion Critical Care. 9: 199. DOI: 10.1186/Cc3262 | 0.301 | |||
| 2004 | Murthy KGK, Szabo C, Salzman AL. Cytokines stimulate expression of inducible nitric oxide synthase in DLD-1 human adenocarcinoma cells by activating poly(A) polymerase. Inflammation Research. 53: 604-608. PMID 15693609 DOI: 10.1007/S00011-004-1301-1 | 0.364 | |||
| 2004 | Szabó G, Soós P, Mandera S, Heger U, Flechtenmacher C, Seres L, Zsengellér Z, Sack FU, Szabo C, Hagl S. Mesenteric injury after cardiopulmonary bypass: role of poly(adenosine 5'-diphosphate-ribose) polymerase. Critical Care Medicine. 32: 2392-2397. PMID 15599141 DOI: 10.1097/01.Ccm.0000148009.48919.6A | 0.346 | |||
| 2004 | Szabó G, Seres L, Soós P, Flechtenmacher C, Zsengellér Z, Sack FU, Szabo C, Hagl S. Poly-ADP-ribose polymerase inhibition reduces mesenteric injury after cardiopulmonary bypass Thoracic and Cardiovascular Surgeon. 52: 338-343. PMID 15573274 DOI: 10.1055/S-2004-821274 | 0.327 | |||
| 2004 | Woolley SM, Farivar AS, Naidu BV, Salzman A, Szabo C, Thomas R, Fraga C, Mulligan MS. Role of poly (ADP) ribose synthetase in lung ischemia-reperfusion injury. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 23: 1290-6. PMID 15539128 DOI: 10.1016/J.Healun.2003.08.036 | 0.383 | |||
| 2004 | Zheng L, Szabó C, Kern TS. Poly(ADP-Ribose) Polymerase Is Involved in the Development of Diabetic Retinopathy via Regulation of Nuclear Factor-κB Diabetes. 53: 2960-2967. PMID 15504977 DOI: 10.2337/Diabetes.53.11.2960 | 0.322 | |||
| 2004 | Szabó C, Pacher P, Zsengellér Z, Vaslin A, Komjáti K, Benkö R, Chen M, Mabley JG, Kollai M. Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activation. Molecular Medicine (Cambridge, Mass.). 10: 28-35. PMID 15502880 DOI: 10.2119/2004-00001.Szabo | 0.369 | |||
| 2004 | Chen M, Zsengellér Z, Xiao CY, Szabo C. Mitochondrial-to-nuclear translocation of apoptosis-inducing factor in cardiac myocytes during oxidant stress: potential role of poly(ADP-ribose) polymerase-1 Cardiovascular Research. 63: 682-688. PMID 15306224 DOI: 10.1016/J.Cardiores.2004.04.018 | 0.354 | |||
| 2004 | Piconi L, Quagliaro L, Ros RD, Assaloni R, Giugliano D, Esposito K, Szabó C, Ceriello A. Intermittent high glucose enhances ICAM-1, VCAM-1, E-selectin and interleukin-6 expression in human umbilical endothelial cells in culture: the role of poly(ADP-ribose) polymerase. Journal of Thrombosis and Haemostasis. 2: 1453-1459. PMID 15304054 DOI: 10.1111/J.1538-7836.2004.00835.X | 0.323 | |||
| 2004 | Lacza Z, Horn TF, Snipes JA, Zhang J, Roychowdhury S, Horváth EM, Figueroa JP, Kollai M, Szabó C, Busija DW. Lack of mitochondrial nitric oxide production in the mouse brain. Journal of Neurochemistry. 90: 942-51. PMID 15287900 DOI: 10.1111/J.1471-4159.2004.02553.X | 0.306 | |||
| 2004 | Benkö R, Pacher P, Vaslin A, Kollai M, Szabó C. Restoration of the endothelial function in the aortic rings of apolipoprotein E deficient mice by pharmacological inhibition of the nuclear enzyme poly(ADP-ribose) polymerase. Life Sciences. 75: 1255-61. PMID 15219813 DOI: 10.1016/J.Lfs.2004.04.007 | 0.339 | |||
| 2004 | Pacher P, Vaslin A, Benko R, Mabley JG, Liaudet L, Haskó G, Marton A, Bátkai S, Kollai M, Szabó C. A new, potent poly(ADP-ribose) polymerase inhibitor improves cardiac and vascular dysfunction associated with advanced aging. The Journal of Pharmacology and Experimental Therapeutics. 311: 485-91. PMID 15213249 DOI: 10.1124/Jpet.104.069658 | 0.341 | |||
| 2004 | Farivar AS, Woolley SM, Fraga CH, Thomas R, Salzman AL, Szabo C, Mulligan MS. Intratracheal poly (ADP) ribose synthetase inhibition ameliorates lung ischemia reperfusion injury. The Annals of Thoracic Surgery. 77: 1938-43. PMID 15172241 DOI: 10.1016/J.Athoracsur.2003.10.120 | 0.329 | |||
| 2004 | Scott GS, Kean RB, Mikheeva T, Fabis MJ, Mabley JG, Szabó C, Hooper DC. The therapeutic effects of PJ34 [N-(6-oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide.HCl], a selective inhibitor of poly(ADP-ribose) polymerase, in experimental allergic encephalomyelitis are associated with immunomodulation. The Journal of Pharmacology and Experimental Therapeutics. 310: 1053-61. PMID 15159442 DOI: 10.1124/Jpet.103.063214 | 0.316 | |||
| 2004 | Mabley JG, Pacher P, Bai P, Wallace R, Goonesekera S, Virag L, Southan GJ, Szabó C. Suppression of intestinal polyposis in Apcmin/+ mice by targeting the nitric oxide or poly(ADP-ribose) pathways. Mutation Research. 548: 107-16. PMID 15063141 DOI: 10.1016/J.Mrfmmm.2004.01.006 | 0.334 | |||
| 2004 | Xiao CY, Chen M, Zsengellér Z, Szabo C. Poly(ADP-Ribose) Polymerase Contributes to the Development of Myocardial Infarction in Diabetic Rats and Regulates the Nuclear Translocation of Apoptosis-Inducing Factor Journal of Pharmacology and Experimental Therapeutics. 310: 498-504. PMID 15054118 DOI: 10.1124/Jpet.104.066803 | 0.329 | |||
| 2004 | Brock WA, Milas L, Bergh S, Lo R, Szabó C, Mason KA. Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase Cancer Letters. 205: 155-160. PMID 15036647 DOI: 10.1016/J.Canlet.2003.10.029 | 0.324 | |||
| 2004 | Mabley JG, Southan GJ, Salzman AL, Szabó C. The combined inducible nitric oxide synthase inhibitor and free radical scavenger guanidinoethyldisulfide prevents multiple low-dose streptozotocin-induced diabetes in vivo and interleukin-1beta-induced suppression of islet insulin secretion in vitro. Pancreas. 28: 39-44. PMID 15028959 DOI: 10.1097/00006676-200403000-00018 | 0.345 | |||
| 2004 | Haskó G, Sitkovsky MV, Szabó C. Immunomodulatory and neuroprotective effects of inosine. Trends in Pharmacological Sciences. 25: 152-7. PMID 15019271 DOI: 10.1016/J.Tips.2004.01.006 | 0.355 | |||
| 2004 | Bakondi E, Bai P, Erdélyi K, Szabó C, Gergely P, Virág L. Cytoprotective effect of gallotannin in oxidatively stressed HaCaT keratinocytes: the role of poly(ADP-ribose) metabolism. Experimental Dermatology. 13: 170-178. PMID 14987257 DOI: 10.1111/J.0906-6705.2004.0150.X | 0.382 | |||
| 2004 | Szabó G, Liaudet L, Hagl S, Szabó C. Poly(ADP-ribose) polymerase activation in the reperfused myocardium Cardiovascular Research. 61: 471-480. PMID 14962478 DOI: 10.1016/J.Cardiores.2003.09.029 | 0.361 | |||
| 2004 | Murthy KGK, Xiao CY, Mabley JG, Chen M, Szabó C. Activation of poly(ADP-ribose) polymerase in circulating leukocytes during myocardial infarction. Shock. 21: 230-234. PMID 14770035 DOI: 10.1097/01.Shk.0000110621.42625.10 | 0.351 | |||
| 2004 | Murakami K, Enkhbaatar P, Shimoda K, Cox RA, Burke AS, Hawkins HK, Traber LD, Schmalstieg FC, Salzman AL, Mabley JG, Komjáti K, Pacher P, Zsengellér Z, Szabó C, Traber DL. Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis. Shock (Augusta, Ga.). 21: 126-33. PMID 14752285 DOI: 10.1097/01.Shk.0000108397.56565.4A | 0.364 | |||
| 2004 | Németh ZH, Wong HR, Odoms K, Deitch EA, Szabó C, Vizi ES, Haskó G. Proteasome inhibitors induce inhibitory kappa B (I kappa B) kinase activation, I kappa B alpha degradation, and nuclear factor kappa B activation in HT-29 cells. Molecular Pharmacology. 65: 342-9. PMID 14742676 DOI: 10.1124/Mol.65.2.342 | 0.301 | |||
| 2004 | Komjáti K, Mabley JG, Virág L, Southan GJ, Salzman AL, Szabó C. Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke. International Journal of Molecular Medicine. 13: 373-382. DOI: 10.3892/Ijmm.13.3.373 | 0.326 | |||
| 2004 | Németh ZH, Deitch EA, Davidson MT, Szabó C, Vizi ES, Haskó G. Erratum: Disruption of the actin cytoskeleton results in nuclear factor-κB activation and inflammatory mediator production in cultured human intestinal epithelial cells (Journal of Cellular Physiology (2004) (71-81) DOI:10.1002/jcp.10477) Journal of Cellular Physiology. 200: 167-168. DOI: 10.1002/Jcp.20117 | 0.302 | |||
| 2003 | Lohinai Z, Mabley JG, Fehér E, Marton A, Komjáti K, Szabó C. Role of the activation of the nuclear enzyme poly(ADP-ribose) polymerase in the pathogenesis of periodontitis. Journal of Dental Research. 82: 987-92. PMID 14630900 DOI: 10.1177/154405910308201210 | 0.349 | |||
| 2003 | Lacza Z, Snipes JA, Zhang J, Horváth EM, Figueroa JP, Szabó C, Busija DW. Mitochondrial nitric oxide synthase is not eNOS, nNOS or iNOS. Free Radical Biology & Medicine. 35: 1217-28. PMID 14607521 DOI: 10.1016/S0891-5849(03)00510-0 | 0.355 | |||
| 2003 | Szabo C. Pathophysiological aspects of cellular pyridine nucleotide metabolism: focus on the vascular endothelium. Review. Acta Physiologica Hungarica. 90: 175-193. PMID 14594189 DOI: 10.1556/Aphysiol.90.2003.3.1 | 0.374 | |||
| 2003 | Du X, Matsumura T, Edelstein D, Rossetti L, Zsengellér Z, Szabó C, Brownlee M. Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. The Journal of Clinical Investigation. 112: 1049-57. PMID 14523042 DOI: 10.1172/Jci18127 | 0.377 | |||
| 2003 | Szabó G, Buhmann V, Andrási T, Stumpf N, Bährle S, Kékesi V, Hagl S, Szabó C, Juhász-Nagy A. Poly-ADP-ribose polymerase inhibition protects against myocardial and endothelial reperfusion injury after hypothermic cardiac arrest. The Journal of Thoracic and Cardiovascular Surgery. 126: 651-658. PMID 14502135 DOI: 10.1016/S0022-5223(02)73235-2 | 0.324 | |||
| 2003 | Naidu BV, Fraga C, Salzman AL, Szabo C, Verrier ED, Mulligan MS. Critical role of reactive nitrogen species in lung ischemia-reperfusion injury Journal of Heart and Lung Transplantation. 22: 784-793. PMID 12873547 DOI: 10.1016/S1053-2498(02)00556-9 | 0.33 | |||
| 2003 | Bakondi E, Gönczi M, Szabó É, Bai P, Pacher P, Gergely P, Kovács L, Hunyadi J, Szabó C, Csernoch L, Virág L. Role of Intracellular Calcium Mobilization and Cell-Density-Dependent Signaling in Oxidative-Stress-Induced Cytotoxicity in HaCaT Keratinocytes Journal of Investigative Dermatology. 121: 88-95. PMID 12839568 DOI: 10.1046/J.1523-1747.2003.12329.X | 0.355 | |||
| 2003 | Suarez-Pinzon WL, Mabley JG, Power R, Szabó C, Rabinovitch A. Poly (ADP-ribose) polymerase inhibition prevents spontaneous and recurrent autoimmune diabetes in NOD mice by inducing apoptosis of islet-infiltrating leukocytes. Diabetes. 52: 1683-1688. PMID 12829633 DOI: 10.2337/Diabetes.52.7.1683 | 0.315 | |||
| 2003 | Németh ZH, Leibovich SJ, Deitch EA, Vizi ES, Szabó C, Hasko G. cDNA microarray analysis reveals a nuclear factor-kappaB-independent regulation of macrophage function by adenosine. The Journal of Pharmacology and Experimental Therapeutics. 306: 1042-9. PMID 12766259 DOI: 10.1124/Jpet.103.052944 | 0.303 | |||
| 2003 | Iványi Z, Hauser B, Pittner A, Asfar P, Vassilev D, Nalos M, Altherr J, Brückner UB, Szabó C, Radermacher P, Fröba G. Systemic and hepatosplanchnic hemodynamic and metabolic effects of the PARP inhibitor PJ34 during hyperdynamic porcine endotoxemia Shock. 19: 415-421. PMID 12744483 DOI: 10.1097/01.Shk.0000048904.46342.22 | 0.348 | |||
| 2003 | Veres B, Gallyas F, Varbiro G, Berente Z, Osz E, Szekeres G, Szabo C, Sumegi B. Decrease of the inflammatory response and induction of the Akt/protein kinase B pathway by poly-(ADP-ribose) polymerase 1 inhibitor in endotoxin-induced septic shock. Biochemical Pharmacology. 65: 1373-82. PMID 12694878 DOI: 10.1016/S0006-2952(03)00077-7 | 0.352 | |||
| 2003 | Mabley J, Soriano F, Pacher P, Haskó G, Marton A, Wallace R, Salzman A, Szabó C. The adenosine A3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide, is protective in two murine models of colitis. European Journal of Pharmacology. 466: 323-9. PMID 12694816 DOI: 10.1016/S0014-2999(03)01570-X | 0.301 | |||
| 2003 | Virág L, Szabó É, Gergely P, Szabó C. Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention Toxicology Letters. 140: 113-124. PMID 12676457 DOI: 10.1016/S0378-4274(02)00508-8 | 0.373 | |||
| 2003 | Szabó C. Multiple pathways of peroxynitrite cytotoxicity Toxicology Letters. 140: 105-112. PMID 12676456 DOI: 10.1016/S0378-4274(02)00507-6 | 0.375 | |||
| 2003 | Liaudet L, Szabó G, Szabó C. Oxidative stress and regional ischemia-reperfusion injury: the peroxynitrite-poly(ADP-ribose) polymerase connection. Coronary Artery Disease. 14: 115-122. PMID 12655275 DOI: 10.1097/00019501-200304000-00004 | 0.305 | |||
| 2003 | Shimoda K, Murakami K, Enkhbaatar P, Traber LD, Cox RA, Hawkins HK, Schmalstieg FC, Komjati K, Mabley JG, Szabo C, Salzman AL, Traber DL. Effect of poly(ADP ribose) synthetase inhibition on burn and smoke inhalation injury in sheep. American Journal of Physiology. Lung Cellular and Molecular Physiology. 285: L240-9. PMID 12626333 DOI: 10.1152/Ajplung.00319.2002 | 0.321 | |||
| 2003 | Pacher P, Liaudet L, Bai P, Mabley JG, Kaminski PM, Virág L, Deb A, Szabó E, Ungvári Z, Wolin MS, Groves JT, Szabó C. Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction. Circulation. 107: 896-904. PMID 12591762 DOI: 10.1161/01.Cir.0000048192.52098.Dd | 0.386 | |||
| 2003 | Southan GJ, Szabó C. Poly(ADP-ribose) polymerase inhibitors. Current Medicinal Chemistry. 10: 321-340. PMID 12570705 DOI: 10.2174/0929867033368376 | 0.369 | |||
| 2003 | Scott GS, Virág L, Szabó C, Hooper DC. Peroxynitrite-induced oligodendrocyte toxicity is not dependent on poly(ADP-ribose) polymerase activation Glia. 41: 105-116. PMID 12509801 DOI: 10.1002/Glia.10137 | 0.353 | |||
| 2003 | Mabley JG, Pacher P, Liaudet L, Soriano FG, Haskó G, Marton A, Szabo C, Salzman AL. Inosine reduces inflammation and improves survival in a murine model of colitis. American Journal of Physiology. Gastrointestinal and Liver Physiology. 284: G138-44. PMID 12388199 DOI: 10.1152/Ajpgi.00060.2002 | 0.322 | |||
| 2003 | Huang H, McIntosh JL, Fang L, Szabo C, Hoyt DG. Integrin-mediated suppression of endotoxin-induced DNA damage in lung endothelial cells is sensitive to poly(ADP-ribose) polymerase-1 gene deletion. International Journal of Molecular Medicine. 12: 533-540. DOI: 10.3892/Ijmm.12.4.533 | 0.317 | |||
| 2002 | Szabo C. PARP as a Drug Target for the Therapy of Diabetic Cardiovascular Dysfunction. Drug News & Perspectives. 15: 197-205. PMID 12677203 DOI: 10.1358/Dnp.2002.15.4.840052 | 0.361 | |||
| 2002 | Kirov MY, Evgenov OV, Kuklin VN, Virág L, Pacher P, Southan GJ, Salzman AL, Szabó C, Bjertnaes LJ. Aerosolized linear polyethylenimine-nitric oxide/nucleophile adduct attenuates endotoxin-induced lung injury in sheep. American Journal of Respiratory and Critical Care Medicine. 166: 1436-1442. PMID 12450933 DOI: 10.1164/Rccm.2202021 | 0.324 | |||
| 2002 | Pacher P, Cziráki A, Mabley JG, Liaudet L, Papp L, Szabó C. Role of poly(ADP-ribose) polymerase activation in endotoxin-induced cardiac collapse in rodents Biochemical Pharmacology. 64: 1785-1791. PMID 12445868 DOI: 10.1016/S0006-2952(02)01421-1 | 0.351 | |||
| 2002 | Bianchi C, Wakiyama H, Faro R, Khan T, McCully JD, Levitsky S, Szabó C, Sellke FW. A novel peroxynitrite decomposer catalyst (FP-15) reduces myocardial infarct size in an in vivo peroxynitrite decomposer and acute ischemia-reperfusion in pigs. The Annals of Thoracic Surgery. 74: 1201-7. PMID 12400769 DOI: 10.1016/S0003-4975(02)03953-X | 0.321 | |||
| 2002 | Pacher P, Liaudet L, Mabley JG, Komjáti K, Szabó C. Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure. Journal of the American College of Cardiology. 40: 1006-1016. PMID 12225730 DOI: 10.1016/S0735-1097(02)02062-4 | 0.331 | |||
| 2002 | Virág L, Szabó C. The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors Pharmacological Reviews. 54: 375-429. PMID 12223530 DOI: 10.1124/Pr.54.3.375 | 0.362 | |||
| 2002 | Németh ZH, Deitch EA, Szabó C, Haskó G. Hyperosmotic stress induces nuclear factor-kappaB activation and interleukin-8 production in human intestinal epithelial cells. The American Journal of Pathology. 161: 987-96. PMID 12213727 DOI: 10.1016/S0002-9440(10)64259-9 | 0.334 | |||
| 2002 | Németh ZH, Deitch EA, Lu Q, Szabó C, Haskó G. NHE blockade inhibits chemokine production and NF-kappaB activation in immunostimulated endothelial cells. American Journal of Physiology. Cell Physiology. 283: C396-403. PMID 12107048 DOI: 10.1152/Ajpcell.00491.2001 | 0.348 | |||
| 2002 | Virág L, Szabó É, Bakondi E, Bai P, Gergely P, Hunyadi J, Szabó C. Nitric oxide-peroxynitrite-poly(ADP-ribose) polymerase pathway in the skin. Experimental Dermatology. 11: 189-202. PMID 12102657 DOI: 10.1034/J.1600-0625.2002.110301.X | 0.321 | |||
| 2002 | Németh ZH, Deitch EA, Szabó C, Mabley JG, Pacher P, Fekete Z, Hauser CJ, Haskó G. Na+/H+ exchanger blockade inhibits enterocyte inflammatory response and protects against colitis. American Journal of Physiology. Gastrointestinal and Liver Physiology. 283: G122-32. PMID 12065299 DOI: 10.1152/Ajpgi.00015.2002 | 0.345 | |||
| 2002 | Szabó C. Does the activation of poly (ADP-ribose) synthetase mediate tissue injury in the sepsis induced by cecal ligation and puncture? Shock 16:137-142, 2001. Shock. 17: 439-440. PMID 12022768 DOI: 10.1097/00024382-200205000-00017 | 0.31 | |||
| 2002 | Soriano FG, Liaudet L, Szabó É, Virág L, Mabley JG, Pacher P, Szabó C. Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice. Shock. 17: 286-292. PMID 11954828 DOI: 10.1097/00024382-200204000-00008 | 0.329 | |||
| 2002 | Liaudet L, Mabley JG, Pacher P, Virág L, Soriano FG, Marton A, Haskó G, Deitch EA, Szabó C. Inosine exerts a broad range of antiinflammatory effects in a murine model of acute lung injury. Annals of Surgery. 235: 568-78. PMID 11923614 DOI: 10.1097/00000658-200204000-00016 | 0.333 | |||
| 2002 | Haskó G, Deitch EA, Németh ZH, Kuhel DG, Szabó C. Inhibitors of ATP-binding cassette transporters suppress interleukin-12 p40 production and major histocompatibility complex II up-regulation in macrophages. The Journal of Pharmacology and Experimental Therapeutics. 301: 103-10. PMID 11907163 DOI: 10.1124/Jpet.301.1.103 | 0.312 | |||
| 2002 | Pacher P, Mabley JG, Soriano FG, Liaudet L, Komjáti K, Szabó C. Endothelial dysfunction in aging animals: The role of poly(ADP-ribose) polymerase activation British Journal of Pharmacology. 135: 1347-1350. PMID 11906946 DOI: 10.1038/Sj.Bjp.0704627 | 0.33 | |||
| 2002 | Pacher P, Liaudet L, Bai P, Virag L, Mabley JG, Haskó G, Szabó C. Activation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failure. Journal of Pharmacology and Experimental Therapeutics. 300: 862-867. PMID 11861791 DOI: 10.1124/Jpet.300.3.862 | 0.379 | |||
| 2002 | Faro R, Toyoda Y, McCully JD, Jagtap P, Szabo E, Virag L, Bianchi C, Levitsky S, Szabo C, Sellke FW. Myocardial protection by PJ34, a novel potent poly (ADP-ribose) synthetase inhibitor. The Annals of Thoracic Surgery. 73: 575-81. PMID 11845877 DOI: 10.1016/S0003-4975(01)03329-X | 0.322 | |||
| 2002 | Liaudet L, Pacher PÁL, Mabley JG, Virág L, Soriano FG, Haskó G, Szabo C. Activation of poly(ADP-Ribose) polymerase-1 is a central mechanism of lipopolysaccharide-induced acute lung inflammation. American Journal of Respiratory and Critical Care Medicine. 165: 372-377. PMID 11818323 DOI: 10.1164/Ajrccm.165.3.2106050 | 0.378 | |||
| 2002 | Pacher P, Liaudet L, Soriano FG, Mabley JG, Szabó É, Szabó C. The Role of Poly(ADP-Ribose) Polymerase Activation in the Development of Myocardial and Endothelial Dysfunction in Diabetes Diabetes. 51: 514-521. PMID 11812763 DOI: 10.2337/Diabetes.51.2.514 | 0.303 | |||
| 2002 | Szabó G, Bährle S, Stumpf N, Sonnenberg K, Szabó É, Pacher P, Csont T, Schulz R, Dengler TJ, Liaudet L, Jagtap PG, Southan GJ, Vahl CF, Hagl S, Szabó C. Poly(ADP-Ribose) Polymerase Inhibition Reduces Reperfusion Injury After Heart Transplantation Circulation Research. 90: 100-106. PMID 11786525 DOI: 10.1161/Hh0102.102657 | 0.315 | |||
| 2002 | Németh ZH, Deitch EA, Szabó C, Fekete Z, Hauser CJ, Haskó G. Lithium induces NF-kappa B activation and interleukin-8 production in human intestinal epithelial cells. The Journal of Biological Chemistry. 277: 7713-9. PMID 11756416 DOI: 10.1074/Jbc.M109711200 | 0.303 | |||
| 2002 | Bakondi E, Bai P, Szabó É, Hunyadi J, Gergely P, Szabó C, Virág L. Detection of Poly(ADP-ribose) Polymerase Activation in Oxidatively Stressed Cells and Tissues Using Biotinylated NAD Substrate Journal of Histochemistry and Cytochemistry. 50: 91-98. PMID 11748298 DOI: 10.1177/002215540205000110 | 0.368 | |||
| 2002 | Liaudet L, Murthy KGK, Mabley JG, Pacher P, Soriano FG, Salzman AL, Szabó C. Comparison of Inflammation, Organ Damage, and Oxidant Stress Induced by Salmonella enterica Serovar Muenchen Flagellin and Serovar Enteritidis Lipopolysaccharide Infection and Immunity. 70: 192-198. PMID 11748182 DOI: 10.1128/Iai.70.1.192-198.2002 | 0.339 | |||
| 2002 | Pacher P, Mabley JG, Soriano FG, Liaudet L, Szabó C. Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging International Journal of Molecular Medicine. 9: 659-664. DOI: 10.3892/Ijmm.9.6.659 | 0.359 | |||
| 2002 | Mabley JG, Liaudet L, Pacher P, Southan GJ, Salzman AL, Szabó C. Part II: beneficial effects of the peroxynitrite decomposition catalyst FP15 in murine models of arthritis and colitis. Molecular Medicine. 8: 581-590. DOI: 10.1007/Bf03402168 | 0.334 | |||
| 2002 | Haskó G, Mabley JG, Németh ZH, Pacher P, Deitch EA, Szabó C. Poly(ADP-ribose) polymerase is a regulator of chemokine production: relevance for the pathogenesis of shock and inflammation Molecular Medicine. 8: 283-289. DOI: 10.1007/Bf03402154 | 0.353 | |||
| 2001 | Lohinai Z, Stachlewitz R, Székely AD, Fehér E, Dézsi L, Szabo C. Evidence for the expression of cyclooxygenase-2 enzyme in periodontitis. Life Sciences. 70: 279-290. PMID 12005261 DOI: 10.1016/S0024-3205(01)01391-1 | 0.316 | |||
| 2001 | Mabley JG, Jagtap P, Perretti M, Getting SJ, Salzman AL, Virág L, Szabó E, Soriano FG, Liaudet L, Abdelkarim GE, Haskó G, Marton A, Southan GJ, Szabó C. Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. 50: 561-9. PMID 11766996 DOI: 10.1007/Pl00000234 | 0.372 | |||
| 2001 | Bai P, Bakondi E, Szabó É, Gergely P, Szabó C, Virág L. Partial protection by poly(ADP-ribose) polymerase inhibitors from nitroxyl-induced cytotoxicity in thymocytes Free Radical Biology and Medicine. 31: 1616-1623. PMID 11744336 DOI: 10.1016/S0891-5849(01)00756-0 | 0.358 | |||
| 2001 | Lakey JRT, Suarez-Pinzon WL, Strynadka K, Korbutt GS, Rajotte RV, Mabley JG, Szabo C, Rabinovitch A. Peroxynitrite Is a Mediator of Cytokine-Induced Destruction of Human Pancreatic Islet β Cells Laboratory Investigation. 81: 1683-1692. PMID 11742038 DOI: 10.1038/Labinvest.3780381 | 0.34 | |||
| 2001 | Soejima K, Schmalstieg FC, Traber LD, Szabo C, Salzman A, Traber DL. Role of nitric oxide in myocardial dysfunction after combined burn and smoke inhalation injury Burns. 27: 809-815. PMID 11718983 DOI: 10.1016/S0305-4179(01)00051-1 | 0.315 | |||
| 2001 | Liaudet L, Mabley JG, Soriano FG, Pacher P, Marton A, Haskó G, Szabó C. Inosine reduces systemic inflammation and improves survival in septic shock induced by cecal ligation and puncture. American Journal of Respiratory and Critical Care Medicine. 164: 1213-20. PMID 11673212 DOI: 10.1164/Ajrccm.164.7.2101013 | 0.347 | |||
| 2001 | Soriano FG, Pacher P, Mabley J, Liaudet L, Szabó C. Rapid Reversal of the Diabetic Endothelial Dysfunction by Pharmacological Inhibition of Poly(ADP-Ribose) Polymerase Circulation Research. 89: 684-691. PMID 11597991 DOI: 10.1161/Hh2001.097797 | 0.333 | |||
| 2001 | Scott GS, Kean RB, Southan GJ, Szabó C, Hooper DC. Effect of mercaptoethylguanidine scavengers of peroxynitrite on the development of experimental allergic encephalomyelitis in PLSJL mice. Neuroscience Letters. 311: 125-8. PMID 11567794 DOI: 10.1016/S0304-3940(01)02160-7 | 0.321 | |||
| 2001 | Haskó G, Szabó C, Németh ZH, Deitch EA. Sulphasalazine inhibits macrophage activation: inhibitory effects on inducible nitric oxide synthase expression, interleukin-12 production and major histocompatibility complex II expression. Immunology. 103: 473-478. PMID 11529938 DOI: 10.1046/J.1365-2567.2001.01272.X | 0.344 | |||
| 2001 | Soriano FG, Virag L, Szabo C. Diabetic endothelial dysfunction: role of reactive oxygen and nitrogen species production and poly(ADP-ribose) polymerase activation. Journal of Molecular Medicine. 79: 437-448. PMID 11511974 DOI: 10.1007/S001090100236 | 0.378 | |||
| 2001 | Ploner F, Radermacher P, Theisen M, Tugtekin IF, Matejovic M, Stehr A, Szabo C, Southan GJ, Georgieff M, Brückner UB, Träger K. Effects of combined selective iNOS inhibition and peroxynitrite blockade during endotoxemia in pigs. Shock. 16: 130-136. PMID 11508865 DOI: 10.1097/00024382-200116020-00008 | 0.359 | |||
| 2001 | Liaudet L, Szabó É, Timashpolsky L, Virág L, Cziráki A, Szabó C. Suppression of poly (ADP-ribose) polymerase activation by 3-aminobenzamide in a rat model of myocardial infarction : long-term morphological and functional consequences British Journal of Pharmacology. 133: 1424-1430. PMID 11498530 DOI: 10.1038/Sj.Bjp.0704185 | 0.354 | |||
| 2001 | Mabley JG, Suarez-Pinzon WL, Haskó G, Salzman AL, Rabinovitch A, Kun E, SzabÓ C. Inhibition of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetes British Journal of Pharmacology. 133: 909-919. PMID 11454665 DOI: 10.1038/Sj.Bjp.0704156 | 0.349 | |||
| 2001 | Szabó É, Virág L, Bakondi E, Gyüre L, Haskó G, Bai P, Hunyadi J, Gergely P, Szabó C. Peroxynitrite Production, DNA Breakage, and Poly(ADP-ribose) Polymerase Activation in a Mouse Model of Oxazolone-Induced Contact Hypersensitivity Journal of Investigative Dermatology. 117: 74-80. PMID 11442752 DOI: 10.1046/J.0022-202X.2001.01388.X | 0.382 | |||
| 2001 | Suarez-Pinzon WL, Mabley JG, Strynadka K, Power RF, Szabó C, Rabinovitch A. An Inhibitor of Inducible Nitric Oxide Synthase and Scavenger of Peroxynitrite Prevents Diabetes Development in NOD Mice Journal of Autoimmunity. 16: 449-455. PMID 11437493 DOI: 10.1006/Jaut.2001.0507 | 0.333 | |||
| 2001 | Scott GS, Hake P, Kean RB, Virág L, Szabó C, Hooper DC. Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis. Journal of Neuroimmunology. 117: 78-86. PMID 11431007 DOI: 10.1016/S0165-5728(01)00329-0 | 0.316 | |||
| 2001 | Lohinai Z, Stachlewitz R, Virág L, Székely AD, Haskó G, Szabo C. Evidence for Reactive Nitrogen Species Formation in the Gingivomucosal Tissue Journal of Dental Research. 80: 470-475. PMID 11332535 DOI: 10.1177/00220345010800021401 | 0.317 | |||
| 2001 | Soejima K, Traber LD, Schmalstieg FC, Hawkins H, Jodoin JM, Szabo C, Szabo E, Varig L, Salzman A, Traber DL. Role of nitric oxide in vascular permeability after combined burns and smoke inhalation injury. American Journal of Respiratory and Critical Care Medicine. 163: 745-752. PMID 11254534 DOI: 10.1164/Ajrccm.163.3.9912052 | 0.332 | |||
| 2001 | Zsengellér ZK, Ross GF, Trapnell BC, Szabó C, Whitsett JA. Adenovirus infection increases iNOS and peroxynitrite production in the lung. American Journal of Physiology. Lung Cellular and Molecular Physiology. 280: L503-11. PMID 11159034 DOI: 10.1152/Ajplung.2001.280.3.L503 | 0.301 | |||
| 2001 | Virág L, Szabó C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death The Faseb Journal. 15: 99-107. PMID 11149897 DOI: 10.1096/Fj.00-0299Com | 0.395 | |||
| 2001 | Eaves-Pyles T, Murthy K, Liaudet L, Virág L, Ross G, Soriano FG, Szabó C, Salzman AL. Flagellin, a Novel Mediator of Salmonella-Induced Epithelial Activation and Systemic Inflammation: IκBα Degradation, Induction of Nitric Oxide Synthase, Induction of Proinflammatory Mediators, and Cardiovascular Dysfunction Journal of Immunology. 166: 1248-1260. PMID 11145708 DOI: 10.4049/Jimmunol.166.2.1248 | 0.347 | |||
| 2001 | Garcia Soriano F, Virág L, Jagtap P, Szabó E, Mabley JG, Liaudet L, Marton A, Hoyt DG, Murthy KG, Salzman AL, Southan GJ, Szabó C. Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation. Nature Medicine. 7: 108-13. PMID 11135624 DOI: 10.1038/83241 | 0.36 | |||
| 2001 | Marton A, Pacher P, Murthy KG, Nemeth ZH, Hasko G, Szabo C. Anti-inflammatory effects of inosine in human monocytes, neutrophils and epithelial cells in vitro. International Journal of Molecular Medicine. 8: 617-621. DOI: 10.3892/Ijmm.8.6.617 | 0.33 | |||
| 2001 | Abdelkarim GE, Gertz K, Harms C, Katchanov J, Dirnagl U, Szabo C, Endres M. Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke. International Journal of Molecular Medicine. 7: 255-260. DOI: 10.3892/Ijmm.7.3.255 | 0.373 | |||
| 2001 | Liaudet L, Yang Z, Al-Affar EB, Szabo C. Myocardial ischemic preconditioning in rodents is dependent on poly (ADP-ribose) synthetase. Molecular Medicine. 7: 406-417. DOI: 10.1007/Bf03402187 | 0.36 | |||
| 2000 | Bernstein T, Szabó C, Salzman AL. Maturation-dependent sequential expression of interferon regulatory factor-1 and inducible nitric oxide synthase in cultured human enterocytes. Shock. 14: 514-521. PMID 11092683 DOI: 10.1097/00024382-200014050-00004 | 0.318 | |||
| 2000 | Virág L, Szabó C. BCL-2 protects peroxynitrite-treated thymocytes from poly(ADP-ribose) synthase (PARS)-independent apoptotic but not from PARS-mediated necrotic cell death. Free Radical Biology and Medicine. 29: 704-713. PMID 11053771 DOI: 10.1016/S0891-5849(00)00359-2 | 0.334 | |||
| 2000 | Liaudet L, Soriano FG, Szabó É, Virág L, Mabley JG, Salzman AL, Szabó C. Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymerase. Proceedings of the National Academy of Sciences of the United States of America. 97: 10203-10208. PMID 10954738 DOI: 10.1073/Pnas.170226797 | 0.361 | |||
| 2000 | Liaudet L, Szabó A, Soriano FG, Zingarelli B, Szabó C, Salzman AL. Poly (ADP-ribose) synthetase mediates intestinal mucosal barrier dysfunction after mesenteric ischemia. Shock. 14: 134-141. PMID 10947156 DOI: 10.1097/00024382-200014020-00010 | 0.393 | |||
| 2000 | Salzman AL, Linn SC, Szabo C. Progesterone inhibits inducible nitric oxide synthase mRNA expression in human intestinal epithelial cells. International Journal of Molecular Medicine. 6: 209-216. PMID 10891568 DOI: 10.3892/Ijmm.6.2.209 | 0.357 | |||
| 2000 | Lorch SA, Foust R, Gow A, Arkovitz M, Salzman AL, Szabo C, Vayert B, Geffard M, Ischiropoulos H. Immunohistochemical localization of protein 3-nitrotyrosine and S- nitrosocysteine in a murine model of inhaled nitric oxide therapy Pediatric Research. 47: 798-805. PMID 10832741 DOI: 10.1203/00006450-200006000-00020 | 0.317 | |||
| 2000 | Haskó G, Kuhel DG, Salzman AL, Szabó C. ATP suppression of interleukin-12 and tumour necrosis factor-α release from macrophages British Journal of Pharmacology. 129: 909-914. PMID 10696089 DOI: 10.1038/Sj.Bjp.0703134 | 0.313 | |||
| 2000 | Zingarelli B, Scott GS, Hake P, Salzman AL, Szabo C. Effects of nicaraven on nitric oxide-related pathways and in shock and inflammation Shock. 13: 126-134. PMID 10670842 DOI: 10.1097/00024382-200013020-00006 | 0.414 | |||
| 2000 | Yang Z, Zingarelli B, Szabó C. Effect of genetic disruption of poly (ADP-ribose) synthetase on delayed production of inflammatory mediators and delayed necrosis during myocardial ischemia-reperfusion injury. Shock. 13: 60-66. PMID 10638671 DOI: 10.1097/00024382-200013010-00011 | 0.327 | |||
| 2000 | Wolfárd A, Kaszaki J, Szabó C, Szalay L, Nagy S, Boros M. Prevention of early myocardial depression in hyperdynamic endotoxemia in dogs. Shock. 13: 46-51. PMID 10638669 DOI: 10.1097/00024382-200013010-00009 | 0.356 | |||
| 2000 | Parikh AA, Moon MR, Pritts TA, Fischer JE, Szabó C, Hasselgren PO, Salzman AL. IL-1beta induction of NF-kappaB activation in human intestinal epithelial cells is independent of oxyradical signaling. Shock (Augusta, Ga.). 13: 8-13. PMID 10638662 DOI: 10.1097/00024382-200013010-00002 | 0.322 | |||
| 2000 | Haskó G, Kuhel DG, Németh ZH, Mabley JG, Stachlewitz RF, Virág L, Lohinai Z, Southan GJ, Salzman AL, Szabó C. Inosine Inhibits Inflammatory Cytokine Production by a Posttranscriptional Mechanism and Protects Against Endotoxin-Induced Shock Journal of Immunology. 164: 1013-1019. PMID 10623851 DOI: 10.4049/Jimmunol.164.2.1013 | 0.329 | |||
| 1999 | Salzman AL, Preiser J, Setchell KDR, Szabo C. Isoflavone-mediated inhibition of tyrosine kinase: a novel antiinflammatory approach. Journal of Medicinal Food. 2: 179-181. PMID 19281374 DOI: 10.1089/Jmf.1999.2.179 | 0.355 | |||
| 1999 | Kennedy M, Wilson L, Szabö C, Salzman AL. 5-aminosalicylic acid inhibits iNOS transcription in human intestinal epithelial cells. International Journal of Molecular Medicine. 4: 437-443. PMID 10493988 DOI: 10.3892/Ijmm.4.4.437 | 0.362 | |||
| 1999 | Szabó C, Billiar TR. Novel roles of nitric oxide in hemorrhagic shock. Shock. 12: 1-9. PMID 10468045 DOI: 10.1097/00024382-199907000-00001 | 0.305 | |||
| 1999 | Wolfárd A, Kaszaki J, Szabo C, Balogh Z, Nagy S, Boros M. Effects of Selective Nitric Oxide Synthase Inhibition in Hyperdynamic Endotoxemia in Dogs European Surgical Research. 31: 314-323. PMID 10449990 DOI: 10.1159/000008708 | 0.366 | |||
| 1999 | Szabo A, Hake P, Salzman AL, Szabo C. Beneficial effects of mercaptoethylguanidine, an inhibitor of the inducible isoform of nitric oxide synthase and a scavenger of peroxynitrite, in a porcine model of delayed hemorrhagic shock. Critical Care Medicine. 27: 1343-1350. PMID 10446830 DOI: 10.1097/00003246-199907000-00027 | 0.326 | |||
| 1999 | Zingarelli B, Szabo C, Salzman AL. Reduced oxidative and nitrosative damage in murine experimental colitis in the absence of inducible nitric oxide synthase Gut. 45: 199-209. PMID 10403731 DOI: 10.1136/Gut.45.2.199 | 0.367 | |||
| 1999 | Whiteman M, Szabó C, Halliwell B. Modulation of peroxynitrite- and hypochlorous acid-induced inactivation of α1-antiproteinase by mercaptoethylguanidine British Journal of Pharmacology. 126: 1646-1652. PMID 10323598 DOI: 10.1038/Sj.Bjp.0702465 | 0.308 | |||
| 1999 | Virág L, Szabó C. Inhibition of poly(ADP‐ribose) synthetase (PARS) and protection against peroxynitrite‐induced cytotoxicity by zinc chelation British Journal of Pharmacology. 126: 769-777. PMID 10188990 DOI: 10.1038/Sj.Bjp.0702332 | 0.393 | |||
| 1999 | Zingarelli B, Szabó C, Salzman AL. Blockade of poly(ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis Gastroenterology. 116: 335-345. PMID 9922314 DOI: 10.1016/S0016-5085(99)70130-7 | 0.373 | |||
| 1999 | Eaves-Pyles T, Szabó C, Salzman AL. Bacterial Invasion Is Not Required for Activation of NF-κB in Enterocytes Infection and Immunity. 67: 800-804. PMID 9916093 DOI: 10.1128/Iai.67.2.800-804.1999 | 0.301 | |||
| 1999 | Kilicturgay AS, Traber LD, Salzman A, Szabo C, Traber DL. Is Inducible Nitric Oxide Synthase Inhibition Benificial In Non-Controled Hemorrhagic Shock?: 161 Shock. 12: 44. DOI: 10.1097/00024382-199911001-00137 | 0.339 | |||
| 1999 | Shanley TP, Salzman AL, Szabo C, Ward PA. The Role Of Nitric Oxide In Igg Immune Complex-Induced Lung Injury In Rats Shock. 11: 57. DOI: 10.1097/00024382-199906001-00200 | 0.304 | |||
| 1999 | Zingarelli B, Szabo C, Salzman AL. Blockade of poly (ADP-Ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis Critical Care Medicine. 27. DOI: 10.1097/00003246-199901001-00078 | 0.343 | |||
| 1998 | Panas D, Khadour FH, Szabó C, Schulz R. Proinflammatory cytokines depress cardiac efficiency by a nitric oxide-dependent mechanism. American Journal of Physiology. Heart and Circulatory Physiology. 275: H1016-H1023. PMID 29591927 DOI: 10.1152/Ajpheart.1998.275.3.H1016 | 0.311 | |||
| 1998 | Zingarelli B, Haskó G, Salzman AL, Szabó C. Effects of a novel guanylyl cyclase inhibitor on the vascular actions of nitric oxide and peroxynitrite in immunostimulated smooth muscle cells and in endotoxic shock. Critical Care Medicine. 27: 1701-1707. PMID 10507586 DOI: 10.1097/00003246-199909000-00001 | 0.379 | |||
| 1998 | Ajuebor MN, Virág L, Flower RJ, Perretti M, Szabó C. Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan‐induced inflammation Immunology. 95: 625-630. PMID 9893055 DOI: 10.1046/J.1365-2567.1998.00644.X | 0.341 | |||
| 1998 | Virág L, Marmer DJ, Szabó C. Crucial Role Of Apopain In The Peroxynitrite-Induced Apoptotic Dna Fragmentation Free Radical Biology and Medicine. 25: 1075-1082. PMID 9870561 DOI: 10.1016/S0891-5849(98)00139-7 | 0.354 | |||
| 1998 | Zingarelli B, Virág L, Szabó A, Cuzzocrea S, Salzman AL, Szabo C. Oxidation, tyrosine nitration and cytostasis induction in the absence of inducible nitric oxide synthase. International Journal of Molecular Medicine. 1: 787-795. PMID 9852297 DOI: 10.3892/Ijmm.1.5.787 | 0.367 | |||
| 1998 | Southan GJ, Salzman AL, Szabó C. Hydroxyguanidines inhibit peroxynitrite-induced oxidation Free Radical Biology and Medicine. 25: 914-925. PMID 9840736 DOI: 10.1016/S0891-5849(98)00120-8 | 0.37 | |||
| 1998 | Szabó A, Hake P, Salzman AL, Szabo C. 3-Aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase, improves hemodynamics and prolongs survival in a porcine model of hemorrhagic shock. Shock. 10: 347-353. PMID 9840650 DOI: 10.1097/00024382-199811000-00007 | 0.333 | |||
| 1998 | Szabó A, Salzman AL, Szabó C. Poly (ADP-ribose) synthetase activation mediates pulmonary microvascular and intestinal mucosal dysfunction in endotoxin shock. Life Sciences. 63: 2133-2139. PMID 9839537 DOI: 10.1016/S0024-3205(99)80010-1 | 0.361 | |||
| 1998 | Haskó G, Németh ZH, Vizi ES, Salzman AL, Szabó C. An agonist of adenosine A3 receptors decreases interleukin-12 and interferon-γ production and prevents lethality in endotoxemic mice European Journal of Pharmacology. 358: 261-268. PMID 9822893 DOI: 10.1016/S0014-2999(98)00619-0 | 0.317 | |||
| 1998 | Haskó G, Szabó C. Regulation of cytokine and chemokine production by transmitters and co-transmitters of the autonomic nervous system Biochemical Pharmacology. 56: 1079-1087. PMID 9802316 DOI: 10.1016/S0006-2952(98)00153-1 | 0.326 | |||
| 1998 | Virág L, Scott GS, Cuzzocrea S, Marmer D, Salzman AL, Szabó C. Peroxynitrite-induced thymocyte apoptosis: the role of caspases and poly (ADP-ribose) synthetase (PARS) activation. Immunology. 94: 345-355. PMID 9767416 DOI: 10.1046/J.1365-2567.1998.00534.X | 0.358 | |||
| 1998 | Endres M, Scott GS, Salzman AL, Kun E, Moskowitz MA, Szabó C. Protective effects of 5-iodo-6-amino-1,2-benzopyrone, an inhibitor of poly(ADP-ribose) synthetase against peroxynitrite-induced glial damage and stroke development. European Journal of Pharmacology. 351: 377-82. PMID 9721031 DOI: 10.1016/S0014-2999(98)00381-1 | 0.339 | |||
| 1998 | Haskó G, Szabó C, Németh ZH, Lendvai B, Vizi ES. Modulation by dantrolene of endotoxin-induced interleukin-10, tumour necrosis factor-alpha and nitric oxide production in vivo and in vitro. British Journal of Pharmacology. 124: 1099-106. PMID 9720779 DOI: 10.1038/Sj.Bjp.0701934 | 0.302 | |||
| 1998 | Szabó C. Role of poly(ADP-ribose) synthetase in inflammation European Journal of Pharmacology. 350: 1-19. PMID 9683009 DOI: 10.1016/S0014-2999(98)00249-0 | 0.401 | |||
| 1998 | Zingarelli B, Salzman AL, Szabó C. Genetic Disruption of Poly (ADP-Ribose) Synthetase Inhibits the Expression of P-Selectin and Intercellular Adhesion Molecule-1 in Myocardial Ischemia/Reperfusion Injury Circulation Research. 83: 85-94. PMID 9670921 DOI: 10.1161/01.Res.83.1.85 | 0.372 | |||
| 1998 | Szabó C. Regulation of the Expression of the Inducible Isoform of Nitric Oxide Synthase by Glucocorticoidsa Annals of the New York Academy of Sciences. 851: 336-341. PMID 9668624 DOI: 10.1111/J.1749-6632.1998.Tb09007.X | 0.318 | |||
| 1998 | Endres M, Scott G, Namura S, Salzman AL, Huang PL, Moskowitz MA, Szabó C. Role of peroxynitrite and neuronal nitric oxide synthase in the activation of poly(ADP-ribose) synthetase in a murine model of cerebral ischemia-reperfusion Neuroscience Letters. 248: 41-44. PMID 9665659 DOI: 10.1016/S0304-3940(98)00224-9 | 0.355 | |||
| 1998 | Virág L, Haskó G, Salzman AL, Szabó C. NADPH Diaphorase Histochemistry Detects Inducible Nitric Oxide Synthetase Activity in the Thymus of Naive and Staphylococcal Enterotoxin B-stimulated Mice Journal of Histochemistry and Cytochemistry. 46: 787-791. PMID 9632737 DOI: 10.1177/002215549804600701 | 0.333 | |||
| 1998 | Gilad E, Wong HR, Zingarelli B, Virág L, O'Connor M, Salzman AL, Szabó C. Melatonin inhibits expression of the inducible isoform of nitric oxide synthase in murine macrophages: role of inhibition of NFκB activation The Faseb Journal. 12: 685-693. PMID 9619447 DOI: 10.1096/Fasebj.12.9.685 | 0.362 | |||
| 1998 | Szabó C. Potential Role Of The Peroxynitrite-poly(adp-ribose) Synthetase Pathway In A Rat Model Of Severe Hemorrhagic Shock Shock. 9: 341-344. PMID 9617883 DOI: 10.1097/00024382-199805000-00005 | 0.377 | |||
| 1998 | Cuzzocrea S, Zingarelli B, Gilad E, Hake P, Salzman AL, Szabó C. Protective effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthase in a carrageenan-induced model of local inflammation European Journal of Pharmacology. 342: 67-76. PMID 9544794 DOI: 10.1016/S0014-2999(97)01417-9 | 0.391 | |||
| 1998 | Szabó C, Virág L, Cuzzocrea S, Scott GS, Hake P, O’Connor MP, Zingarelli B, Salzman A, Kun E. Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase. Proceedings of the National Academy of Sciences of the United States of America. 95: 3867-3872. PMID 9520459 DOI: 10.1073/Pnas.95.7.3867 | 0.418 | |||
| 1998 | Cuzzocrea S, Zingarelli B, O'Connor M, Salzman AL, Szabó C. Effect of L‐buthionine‐(S,R)‐sulphoximine, an inhibitor of γ‐glutamylcysteine synthetase on peroxynitrite‐ and endotoxic shock‐induced vascular failure British Journal of Pharmacology. 123: 525-537. PMID 9504394 DOI: 10.1038/Sj.Bjp.0701612 | 0.418 | |||
| 1998 | Lohinai Z, Benedek P, Fehér E, Györfi A, Rosivall L, Fazekas A, Salzman AL, Szabó C. Protective effects of mercaptoethylguanidine, a selective inhibitor of inducible nitric oxide synthase, in ligature-induced periodontitis in the rat British Journal of Pharmacology. 123: 353-360. PMID 9504374 DOI: 10.1038/Sj.Bjp.0701604 | 0.336 | |||
| 1998 | Kennedy M, Denenberg AG, Szabó C, Salzman AL. Poly(ADP-ribose) synthetase activation mediates increased permeability induced by peroxynitrite in Caco-2BBe cells Gastroenterology. 114: 510-518. PMID 9496941 DOI: 10.1016/S0016-5085(98)70534-7 | 0.394 | |||
| 1998 | Haskó G, Németh ZH, Szabó C, Zsilla G, Salzman AL, Vizi ES. Isoproterenol inhibits Il-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages. Brain Research Bulletin. 45: 183-7. PMID 9443838 DOI: 10.1016/S0361-9230(97)00337-7 | 0.329 | |||
| 1998 | Cuzzocrea S, Zingarelli B, Hake P, Salzman AL, Szabo C. Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation Free Radical Biology and Medicine. 24: 450-459. PMID 9438558 DOI: 10.1016/S0891-5849(97)00280-3 | 0.405 | |||
| 1998 | Salzman AL, Eaves–Pyles T, Linn SC, Denenberg AG, Szabó C. Bacterial induction of inducible nitric oxide synthase in cultured human intestinal epithelial cells Gastroenterology. 114: 93-102. PMID 9428223 DOI: 10.1016/S0016-5085(98)70637-7 | 0.364 | |||
| 1998 | Szabó C, Virág L, Zingarelli B, Szabó A, Cuzzocrea C, Salzman AL. Peroxyn1Trite-Dependent And Peroxynitrite - Independent Cytotoxic Mechanisms In The Absence Of Inducible Nitric Oxide Synthase.: 202 Shock. 9: 60. DOI: 10.1097/00024382-199806001-00202 | 0.342 | |||
| 1998 | Preiser J-, Szabó C, Salzman AL. Induction Of Nitric Oxide Production In Human Epithelial Cells Involves Tyrosine Phosphorylation.: 199 Shock. 9: 59. DOI: 10.1097/00024382-199806001-00199 | 0.32 | |||
| 1998 | Kennedy MS, Denenberg A, Szabó C, Salzman AL. 5-AMINOSALICYLIC ACID (5-ASA) INHIBITS INDUCIBLE NITRIC OXIDE SYNTHASE (iNOS) EXPRESSION IN HUMAN INTESTINAL EPITHELIAL CELLS.: 195 Shock. 9: 58. DOI: 10.1097/00024382-199806001-00195 | 0.344 | |||
| 1998 | Zingarelli B, Szabó C, Salzman AL. Absence Of Inducible Nitric Oxide Synthase Reduces Lethality In Tnbsinduced Colitis.: 134 Shock. 9: 40. DOI: 10.1097/00024382-199806001-00134 | 0.343 | |||
| 1998 | Salzman AL, Denenberg AG, Linn SC, Szabó C. PROGESTERONE REGULATES INDUCIBLE NITRIC OXIDE SYNTHASE mRNA EXPRESSION IN HUMAN INTESTINAL EPITHELIAL CELLS AT A POST-TRANSCRIPTIONAL LEVEL.: 70 Shock. 9: 21. DOI: 10.1097/00024382-199806001-00070 | 0.318 | |||
| 1998 | Virág L, Salzman AL, Szabó C. Role Of Poly (Adp-Ribose) Synthetase (Pars) Activation In The Alterations In Mitochondrial Function In Peroxynitrite Treated Cells.: 40 Shock. 9: 12. DOI: 10.1097/00024382-199806001-00040 | 0.327 | |||
| 1998 | Szabo C. Inhibition of poly (ADP-nbose) synthetase ameliorates neutrophil recruitment in vivo Critical Care Medicine. 26. DOI: 10.1097/00003246-199801001-00192 | 0.312 | |||
| 1998 | Gilad E, Cuzzocrea S, Zingarelli B, Woog HR, Salzman AL, Szabo C. Melatonin inhibits the expression of the inducible isoform of nitric oxide synthase and exerts protective effects in a carrageenan-induced model of inflammation Critical Care Medicine. 26. DOI: 10.1097/00003246-199801001-00181 | 0.363 | |||
| 1998 | Hasko G, Nemeth Z, Vizi SE, Salzman AL, Szabo C. THE PHOSPHODIESTERASE III INHIBITOR AMRINONE MODULATES CYTOKINE AND NITRIC OXIDE PRODUCTION IN IMMUNOSTIMULATED MACROPHAGES Critical Care Medicine. 26: 73A. DOI: 10.1097/00003246-199801001-00178 | 0.314 | |||
| 1998 | Lohinai Z, Benedek P, Feher E, Gyorfi A, Rosivall L, Fazekas A, Salzman AL, Szabo C. Corrigendum: Protective effects of mercoptoethylguanidine, a selective inhibitor of inducible nitric oxide synthase, in ligature-induced periodontitis in the rat (Journal of Pharmacology (1998) 123 (353-360)) British Journal of Pharmacology. 123: 1741. DOI: 10.1038/Sj.Bjp.0701816 | 0.341 | |||
| 1998 | Szabo C. Molecular Mechanisms of the Nitric Oxide Induced Vessel Wall Dysfunction in Sepsis Sepsis. 1: 107-114. DOI: 10.1023/A:1009776408427 | 0.32 | |||
| 1997 | Németh ZH, Szabó C, Haskó G, Salzman AL, Vizi ES. Effect of the phosphodiesterase III inhibitor amrinone on cytokine and nitric oxide production in immunostimulated J774.1 macrophages. European Journal of Pharmacology. 339: 215-221. PMID 9473138 DOI: 10.1016/S0014-2999(97)01392-7 | 0.35 | |||
| 1997 | Zingarelli B, Cuzzocrea S, Zsengellér Z, Salzman AL, Szabó C. Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase Cardiovascular Research. 36: 205-215. PMID 9463632 DOI: 10.1016/S0008-6363(97)00137-5 | 0.344 | |||
| 1997 | Zingarelli B, Ischiropoulos H, Salzman AL, Szabó C. Amelioration by mercaptoethylguanidine of the vascular and energetic failure in haemorrhagic shock in the anesthetised rat European Journal of Pharmacology. 338: 55-65. PMID 9408003 DOI: 10.1016/S0014-2999(97)01325-3 | 0.358 | |||
| 1997 | Cuzzocrea S, Zingarelli B, Gilad E, Hake P, Salzman AL, Szabó C. Protective effect of melatonin in carrageenan-induced models of local inflammation: relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity. Journal of Pineal Research. 23: 106-116. PMID 9392449 DOI: 10.1111/J.1600-079X.1997.Tb00342.X | 0.39 | |||
| 1997 | Szabo C. Role of poly(ADP-ribose) synthetase activation in the suppression of cellular energetics in response to nitric oxide and peroxynitrite Biochemical Society Transactions. 25: 919-924. PMID 9388573 DOI: 10.1042/Bst0250919 | 0.334 | |||
| 1997 | Cuzzocrea S, Zingarelli B, O'Connor M, Salzman AL, Caputi AP, Szabó C. Role of peroxynitrite and activation of poly (ADP‐ribose) synthetase in the vascular failure induced by zymosan‐activated plasma British Journal of Pharmacology. 122: 493-503. PMID 9351506 DOI: 10.1038/Sj.Bjp.0701387 | 0.399 | |||
| 1997 | Szabó C, Lim LHK, Cuzzocrea S, Getting SJ, Zingarelli B, Flower RJ, Salzman AL, Perretti M. Inhibition of poly (ADP-ribose) Synthetase Attenuates Neutrophil Recruitment and Exerts Antiinflammatory Effects Journal of Experimental Medicine. 186: 1041-1049. PMID 9314553 DOI: 10.1084/Jem.186.7.1041 | 0.376 | |||
| 1997 | Gardner PR, Costantino G, Szabó C, Salzman AL. Nitric oxide sensitivity of the aconitases. The Journal of Biological Chemistry. 272: 25071-6. PMID 9312115 DOI: 10.1074/Jbc.272.40.25071 | 0.32 | |||
| 1997 | Gilad E, Zingarelli B, Salzman AL, Szabó C. Protection by inhibition of poly (ADP-ribose) synthetase against oxidant injury in cardiac myoblasts In vitro. Journal of Molecular and Cellular Cardiology. 29: 2585-2597. PMID 9299380 DOI: 10.1006/Jmcc.1997.0496 | 0.431 | |||
| 1997 | Szabo C. Nitric oxide, perioxynitrite and poly(ADP-ribose) synthetase in anaphylactic shock. Shock. 8: 153-154. PMID 9261909 DOI: 10.1097/00024382-199708000-00017 | 0.305 | |||
| 1997 | Invernizzi P, Salzman AL, Szabó C, Ueta I, O'Connor M, Setchell KDR. Ursodeoxycholate inhibits induction of NOS in human intestinal epithelial cells and in vivo American Journal of Physiology-Gastrointestinal and Liver Physiology. 273. PMID 9252519 DOI: 10.1152/Ajpgi.1997.273.1.G131 | 0.386 | |||
| 1997 | Cuzzocrea S, Zingarelli B, Costantino G, Szabó A, Salzman AL, Caputi AP, Szabó C. Beneficial effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion British Journal of Pharmacology. 121: 1065-1074. PMID 9249240 DOI: 10.1038/Sj.Bjp.0701234 | 0.377 | |||
| 1997 | Szabo C, Cuzzocrea S, Zingarelli B, O'Connor M, Salzman AL. Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite. Journal of Clinical Investigation. 100: 723-735. PMID 9239421 DOI: 10.1172/Jci119585 | 0.4 | |||
| 1997 | Linn SC, Morelli PJ, Edry I, Cottongim SE, Szabó C, Salzman AL. Transcriptional regulation of human inducible nitric oxide synthase gene in an intestinal epithelial cell line American Journal of Physiology - Gastrointestinal and Liver Physiology. 272. PMID 9227487 DOI: 10.1152/Ajpgi.1997.272.6.G1499 | 0.336 | |||
| 1997 | Szabó C, O'Connor M, Salzman AL. Endogenously produced peroxynitrite induces the oxidation of mitochondrial and nuclear proteins in immunostimulated macrophages Febs Letters. 409: 147-150. PMID 9202135 DOI: 10.1016/S0014-5793(97)00466-3 | 0.347 | |||
| 1997 | Hrabák A, Bajor T, Southan GJ, Salzman AL, Szabó C. Comparison of the inhibitory effect of isothiourea and mercapto-alkylguanidine derivatives on the alternative pathways of arginine metabolism in macrophages. Life Sciences. 60. PMID 9199488 DOI: 10.1016/S0024-3205(97)00328-7 | 0.351 | |||
| 1997 | Németh ZH, Haskó G, Szabo C, Vizi ES. Amrinone and theophylline differentially regulate cytokine and nitric oxide production in endotoxemic mice Shock. 7: 371-375. PMID 9165673 DOI: 10.1097/00024382-199705000-00010 | 0.311 | |||
| 1997 | Arkovitz MS, Szabó C, Garcia VF, Wong HR, Wispé JR. Differential effects of hyperoxia on the inducible and constitutive isoforms of nitric oxide synthase in the lung. Shock (Augusta, Ga.). 7: 345-50. PMID 9165669 DOI: 10.1097/00024382-199705000-00006 | 0.353 | |||
| 1997 | Kilbourn RG, Traber DL, Szabo C. Nitric oxide and shock Disease-a-Month. 43: 282-348. PMID 9164422 DOI: 10.1016/S0011-5029(97)90028-6 | 0.32 | |||
| 1997 | Murrell GAC, Szabo C, Hannafin JA, Jang D, Dolan MM, Deng X-, Murrell DF, Warren RF. Modulation of tendon healing by nitric oxide. Inflammation Research. 46: 19-27. PMID 9117513 DOI: 10.1007/S000110050027 | 0.316 | |||
| 1997 | Zingarelli B, Day BJ, Crapo JD, Salzman AL, Szabó C. The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock. British Journal of Pharmacology. 120: 259-67. PMID 9117118 DOI: 10.1038/Sj.Bjp.0700872 | 0.416 | |||
| 1997 | Kilbourn RG, Szabó C, Traber DL. Beneficial versus detrimental effects of nitric oxide synthase inhibitors in circulatory shock: Lessons learned from experimental and clinical studies Shock. 7: 235-246. PMID 9110408 DOI: 10.1097/00024382-199704000-00001 | 0.367 | |||
| 1997 | Szabó C, Ferrer-Sueta G, Zingarelli B, Southan GJ, Salzman AL, Radi R. Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage. The Journal of Biological Chemistry. 272: 9030-6. PMID 9083027 DOI: 10.1074/Jbc.272.14.9030 | 0.375 | |||
| 1997 | Gilad E, Cuzzocrea S, Zingarelli B, Salzman AL, Szabó C. Melatonin Is A Scavenger Of Peroxynitrite Life Sciences. 60. PMID 9064472 DOI: 10.1016/S0024-3205(97)00008-8 | 0.358 | |||
| 1997 | Sun X, Wei S, Szabo C, Dusting GJ. Depression of the inotropic action of isoprenaline by nitric oxide synthase induction in rat isolated hearts European Journal of Pharmacology. 320: 29-35. PMID 9049599 DOI: 10.1016/S0014-2999(96)00878-3 | 0.333 | |||
| 1997 | Szabó C, Haskó G, Zingarelli B, Németh ZH, Salzman AL, Kvetan V, Pastores SM, Vizi ES. Isoproterenol regulates tumour necrosis factor, interleukin-10, interleukin-6 and nitric oxide production and protects against the development of vascular hyporeactivity in endotoxaemia. Immunology. 90: 95-100. PMID 9038718 DOI: 10.1046/J.1365-2567.1997.00137.X | 0.351 | |||
| 1997 | Szabo C, Saunders C, O'Connor M, Salzman AL. Peroxynitrite causes energy depletion and increases permeability via activation of poly (ADP-ribose) synthetase in pulmonary epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 16: 105-109. PMID 9032115 DOI: 10.1165/Ajrcmb.16.2.9032115 | 0.362 | |||
| 1997 | Zingarelli B, Southan GJ, Gilad E, O'Connor M, Salzman AL, Szabö C. The inhibitory effects of mercaptoalkylguanidines on cyclo‐oxygenase activity British Journal of Pharmacology. 120: 357-366. PMID 9031736 DOI: 10.1038/Sj.Bjp.0700892 | 0.367 | |||
| 1997 | Morelli PJ, Linn SC, Edry I, Cottingim SE, Szabó C, Salzman AL. Transcriptional Regulation of the Human Inducible Nitric Oxide Synthase Gene in an Intestinal Epithelial Cell Line † 127 Pediatric Research. 41: 24-24. DOI: 10.1203/00006450-199704001-00147 | 0.314 | |||
| 1997 | Zingarelli B, Cuzzocrea S, OʼConnor M, Zsengeller Z, Salzman AL, Szabó C. Poly (Adp-Ribose) Synthetase Activation Induced By Peroxynitrite Mediates Myocardial Ischemia And Reperfusion Injury: 351 Shock. 7: 89. DOI: 10.1097/00024382-199703001-00361 | 0.317 | |||
| 1997 | Németh Z, Haskó G, Szabó C, Vizi SE. Effect Of Amnirone On Cytokine And Nitric Oxide Production In Immunostimulated Macrophages And In Endotoxemic Mice: 277 Shock. 7: 70. DOI: 10.1097/00024382-199703001-00282 | 0.31 | |||
| 1997 | Szabó C, Zingarelli B, Vromen A, Salzman AL. Effects Of Mercaptoethylguanidine, A Selective Inhibitor Of The Inducible Isoform Of Nitric Oxide Synthase, In Endotoxic Shock, Hemorrhagic Shock And Polymicrobial Sepsis: 268 Shock. 7: 68. DOI: 10.1097/00024382-199703001-00273 | 0.334 | |||
| 1997 | Szabó C. Nitric oxide, peroxynitrite and poly (adpribose) synthetase activation: role in the suppression of cellular energetics Biochemical Society Transactions. 25. DOI: 10.1042/Bst025384Sa | 0.332 | |||
| 1996 | Szabó C, Wong HR, Salzman AL. Pre-exposure to heat shock inhibits peroxynitrite-induced activation of poly(ADP) ribosyltransferase and protects against peroxynitrite cytotoxicity in J774 macrophages European Journal of Pharmacology. 315: 221-226. PMID 8960887 DOI: 10.1016/S0014-2999(96)00628-0 | 0.318 | |||
| 1996 | Salzman A, Denenberg AG, Ueta I, O'Connor M, Linn SC, Szabó C. Induction and activity of nitric oxide synthase in cultured human intestinal epithelial monolayers. The American Journal of Physiology. 270: G565-73. PMID 8928785 DOI: 10.1152/Ajpgi.1996.270.4.G565 | 0.343 | |||
| 1996 | Vromen A, Arkovitz MS, Zingarelli B, Salzman AL, Garcia VF, Szabó C. Low-level expression and limited role for the inducible isoform of nitric oxide synthase in the vascular hyporeactivity and mortality associated with cecal ligation and puncture in the rat. Shock (Augusta, Ga.). 6: 248-53. PMID 8902940 DOI: 10.1097/00024382-199610000-00004 | 0.368 | |||
| 1996 | SzabÓ C. DNA strand breakage and activation of poly-ADP ribosyltransferase: a cytotoxic pathway triggered by peroxynitrite. Free Radical Biology and Medicine. 21: 855-869. PMID 8902531 DOI: 10.1016/0891-5849(96)00170-0 | 0.371 | |||
| 1996 | Jang D, Szabo C, Murrell GAC. S-Substituted isothioureas are potent inhibitors of nitric oxide biosynthesis in cartilage European Journal of Pharmacology. 312: 341-347. PMID 8894617 DOI: 10.1016/0014-2999(96)00369-X | 0.309 | |||
| 1996 | Szabo C. Physiological and pathophysiological roles of nitric oxide in the central nervous system Brain Research Bulletin. 41: 131-141. PMID 8886382 DOI: 10.1016/0361-9230(96)00159-1 | 0.35 | |||
| 1996 | Vromen A, Szabo C, Southan GJ, Salzman AL. Effects of S-isopropyl isothiourea, a potent inhibitor of nitric oxide synthase, in severe hemorrhagic shock Journal of Applied Physiology. 81: 707-715. PMID 8872637 DOI: 10.1152/Jappl.1996.81.2.707 | 0.319 | |||
| 1996 | Arkovitz MS, Wispé JR, Garcia VF, Szabó C. Selective inhibition of the inducible isoform of nitric oxide synthase prevents pulmonary transvascular flux during acute endotoxemia. Journal of Pediatric Surgery. 31: 1009-15. PMID 8863222 DOI: 10.1016/S0022-3468(96)90075-5 | 0.351 | |||
| 1996 | Szabó C. The pathophysiological role of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury Shock. 6: 79-88. PMID 8856840 DOI: 10.1097/00024382-199608000-00001 | 0.34 | |||
| 1996 | Szabó C, Salzman AL. Inhibition of terminal calcium overload protects against peroxynitrite-induced cellular injury in macrophages. Immunology Letters. 51: 163-167. PMID 8832286 DOI: 10.1016/0165-2478(96)02568-0 | 0.368 | |||
| 1996 | Zingarelli B, Salzman AL, Szabo C. Protective effects of nicotinamide against nitric oxide-mediated delayed vascular failure in endotoxic shock: potential involvement of polyADP ribosyl synthetase. Shock. 5: 258-264. PMID 8721385 DOI: 10.1097/00024382-199604000-00005 | 0.358 | |||
| 1996 | Szabo C, Zingarelli B, O'Connor M, Salzman AL. DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite Proceedings of the National Academy of Sciences of the United States of America. 93: 1753-1758. PMID 8700830 DOI: 10.1073/Pnas.93.5.1753 | 0.382 | |||
| 1996 | Southan GJ, Zingarelli B, O'Connor M, Salzman AL, Szabó C. Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform British Journal of Pharmacology. 117: 619-632. PMID 8646406 DOI: 10.1111/J.1476-5381.1996.Tb15236.X | 0.34 | |||
| 1996 | Szabó C, Day BJ, Salzman AL. Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger Febs Letters. 381: 82-86. PMID 8641445 DOI: 10.1016/0014-5793(96)00087-7 | 0.376 | |||
| 1996 | Szabó C, Zingarelli B, Salzman AL. Role of Poly-ADP Ribosyltransferase Activation in the Vascular Contractile and Energetic Failure Elicited by Exogenous and Endogenous Nitric Oxide and Peroxynitrite Circulation Research. 78: 1051-1063. PMID 8635236 DOI: 10.1161/01.Res.78.6.1051 | 0.339 | |||
| 1996 | Southan GJ, Szabó C. Selective pharmacological inhibition of distinct nitric oxide synthase isoforms Biochemical Pharmacology. 51: 383-394. PMID 8619882 DOI: 10.1016/0006-2952(95)02099-3 | 0.34 | |||
| 1996 | Southan GJ, Salzman AL, Szabó C. Potent inhibition of the inducible isoform of nitric oxide synthase by aminoethylisoselenourea and related compounds. Life Sciences. 58: 1139-1148. PMID 8614265 DOI: 10.1016/0024-3205(96)00072-0 | 0.339 | |||
| 1996 | Murrell GAC, Dolan MM, Jang D, Szabo C, Warren RF, Hannafin JA. Nitric oxide: an important articular free radical. Journal of Bone and Joint Surgery, American Volume. 78: 265-274. DOI: 10.2106/00004623-199602000-00014 | 0.361 | |||
| 1996 | Southan GJ, Zingarelli B, Salzman AL, Szabó C. Beneficial Effects Of Guanidino-Ethyl-Disulfide (Ged), A Novel Nitric Oxide Synthase Inhibitor In Rodent Models Of Endotoxin Shock.: 205 Shock. 5: 64. DOI: 10.1097/00024382-199606002-00205 | 0.338 | |||
| 1996 | Salzman AL, Ueta I, Szabó C. Inhibitory Effect Of Estrogen And Progesterone On The Expression And Activity Of The Inducible Nitric Oxide Synthase In Human Intestinal Epithelial Cell Monolayers.: 202 Shock. 5: 63. DOI: 10.1097/00024382-199606002-00202 | 0.35 | |||
| 1996 | Linn SC, Morelli PJ, Szabó C, Salzman AL. Transcriptional Regulation Of The Human Inducible Nitric Oxide Synthase Gene In A Colonic Epithelial Cell Line.: 195 Shock. 5: 61. DOI: 10.1097/00024382-199606002-00195 | 0.314 | |||
| 1996 | Kennedy M, Szabó C, Salzman AL. Activation Of Poly (Adp) Ribosyl Synthetase (Pars) Mediates Cytotoxicity Induced By Peroxynitrite In Human Intestinal Epithelial Cells.: 193 Shock. 5: 60-61. DOI: 10.1097/00024382-199606002-00193 | 0.326 | |||
| 1996 | Gilad E, Zingarelli B, OʼConnor M, Salzman AL, Bertók L, Szabó C. Development Of Endotoxin Tolerance By Radio-Detoxified Endotoxin Suppresses Nitric Oxide And Prostaglandin Synthesis.: 188 Shock. 5: 59. DOI: 10.1097/00024382-199606002-00188 | 0.302 | |||
| 1996 | Haskó G, Németh Z, Vizi ES, Szabó C. ANTI-INFLAMMATORY PROFILE OF DANTROLENE: INHIBITION OF ENDOTOXIN-INDUCED TUMOR NECROSIS FACTOR AND ENHANCEMENT OF INTERLEUKIN - 10 PRODUCTION, BUT NO EFFECT ON NITRIC OXIDE AND INTERLEUKIN-6 PRODUCTION. Shock. 5: 45-46. DOI: 10.1097/00024382-199606002-00145 | 0.327 | |||
| 1996 | Eaves-Pyles T, Szabó C, Salzman AL. Interferon-Gamma Primes Cultured Human Intestinal Epithelial Cells For Induction Of Nitric Oxide Synthase By Lipopolysaccharide Or Live Bacteria.: 75 Shock. 5: 23-24. DOI: 10.1097/00024382-199606002-00075 | 0.312 | |||
| 1995 | Southan GJ, Szabó C, Connor MP, Salzman AL, Thiemermann C. Amidines are potent inhibitors of nitric oxide synthases: preferential inhibition of the inducible isoform. European Journal of Pharmacology. 291: 311-8. PMID 8719415 DOI: 10.1016/0922-4106(95)90071-3 | 0.324 | |||
| 1995 | Hattori Y, Szabó C, Gross SS, Thiemermann C, Vane JR. Lipid A and the lipid A analogue anti-tumour compound ONO-4007 induce nitric oxide synthese in vitro and in vivo European Journal of Pharmacology: Molecular Pharmacology. 291: 83-90. PMID 8566179 DOI: 10.1016/0922-4106(95)90128-0 | 0.312 | |||
| 1995 | Szabó C, Thiemermann C. Regulation of the expression of the inducible isoform of nitric oxide synthase. Advances in Pharmacology (San Diego). 34: 113-153. PMID 8562430 DOI: 10.1016/S1054-3589(08)61083-2 | 0.323 | |||
| 1995 | Szabó C, Salzman AL, Ischiropoulos H. Peroxynitrite-mediated oxidation of dihydrorhodamine 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemia-reperfusion injury Febs Letters. 372: 229-232. PMID 7556674 DOI: 10.1016/0014-5793(95)00984-H | 0.357 | |||
| 1995 | Szabó C, Salzman AL, Ischiropoulos H. Endotoxin triggers the expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in the rat aorta in vivo Febs Letters. 363: 235-238. PMID 7537701 DOI: 10.1016/0014-5793(95)00322-Z | 0.379 | |||
| 1995 | Southan GJ, Szabó C, Thiemermann C. Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity British Journal of Pharmacology. 114: 510-516. PMID 7533622 DOI: 10.1111/J.1476-5381.1995.Tb13256.X | 0.356 | |||
| 1995 | O'Connor M, Salzman AL, Szabo C. Role of peroxynitrite in the protein oxidation and apoptotic dna fragmentation in vascular smooth muscle cells stimulated with bacterial lipopolysaccharide and interferon-γ Shock. 8: 439-443. DOI: 10.1097/00024382-199512000-00008 | 0.342 | |||
| 1995 | Szabó C, Southan GJ, Thiemermann C. 233 Non-Arginine Based, Selective Inhibitors Of Inducible No Synthase Exert Beneficial Effects In Endotoxic Shock Shock. 3: 72. DOI: 10.1097/00024382-199505000-00233 | 0.309 | |||
| 1994 | Szabó C, Southan GJ, Thiemermann C, Vane JR. The mechanism of the inhibitory effect of polyamines on the induction of nitric oxide synthase: role of aldehyde metabolites. British Journal of Pharmacology. 113: 757-766. PMID 7532082 DOI: 10.1111/J.1476-5381.1994.Tb17058.X | 0.39 | |||
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