| Year |
Citation |
Score |
| 2024 |
Dong XD, Lu Q, Li YD, Cai CY, Teng QX, Lei ZN, Wei ZH, Yin F, Zeng L, Chen ZS. RN486, a Bruton's Tyrosine Kinase inhibitor, antagonizes multidrug resistance in ABCG2-overexpressing cancer cells. Journal of Translational Internal Medicine. 12: 288-298. PMID 39081282 DOI: 10.2478/jtim-2024-0011 |
0.513 |
|
| 2024 |
Fan FM, Fleishman JS, Chen J, Chen ZS, Dong HH. New insights into the mechanism of resistance to lenvatinib and strategies for lenvatinib sensitization in hepatocellular carcinoma. Drug Discovery Today. 104069. PMID 38936692 DOI: 10.1016/j.drudis.2024.104069 |
0.368 |
|
| 2024 |
Song W, Yang H, Wang Y, Chen S, Zhong W, Wang Q, Ding W, Xu G, Meng C, Liang Y, Chen ZS, Cao S, Wei L, Li F. Glutathione-Sensitive Photosensitizer-Drug Conjugates Target the Mitochondria to Overcome Multi-Drug Resistance in Cancer. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2307765. PMID 38898730 DOI: 10.1002/advs.202307765 |
0.406 |
|
| 2024 |
Ji N, Li H, Zhang Y, Li Y, Wang P, Chen X, Liu YN, Wang JQ, Yang Y, Chen ZS, Li Y, Wang R, Kong D. Lansoprazole (LPZ) reverses multidrug resistance (MDR) in cancer through impeding ATP-binding cassette (ABC) transporter-mediated chemotherapeutic drug efflux and lysosomal sequestration. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 76: 101100. PMID 38885537 DOI: 10.1016/j.drup.2024.101100 |
0.581 |
|
| 2024 |
Wang Y, Cheng S, Fleishman JS, Chen J, Tang H, Chen ZS, Chen W, Ding M. Targeting anoikis resistance as a strategy for cancer therapy. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 75: 101099. PMID 38850692 DOI: 10.1016/j.drup.2024.101099 |
0.459 |
|
| 2024 |
Chen XY, Wu ZX, Wang JQ, Teng QX, Tang H, Liu Q, Chen ZS, Chen W. Multidrug resistance transporters P-gp and BCRP limit the efficacy of ATR inhibitor ceralasertib in cancer cells. Frontiers in Pharmacology. 15: 1400699. PMID 38756373 DOI: 10.3389/fphar.2024.1400699 |
0.556 |
|
| 2024 |
Sheikh A, Kesharwani P, Almalki WH, Almujri SS, Dai L, Chen ZS, Sahebkar A, Gao F. Understanding the Novel Approach of Nanoferroptosis for Cancer Therapy. Nano-Micro Letters. 16: 188. PMID 38698113 DOI: 10.1007/s40820-024-01399-0 |
0.302 |
|
| 2024 |
Patel H, Li J, Bo L, Mehta R, Ashby CR, Wang S, Cai W, Chen ZS. Nanotechnology-based delivery systems to overcome drug resistance in cancer. Medical Review (2021). 4: 5-30. PMID 38515777 DOI: 10.1515/mr-2023-0058 |
0.4 |
|
| 2024 |
Lei ZN, Albadari N, Teng QX, Rahman H, Wang JQ, Wu Z, Ma D, Ambudkar SV, Wurpel JND, Pan Y, Li W, Chen ZS. ABCB1-dependent collateral sensitivity of multidrug-resistant colorectal cancer cells to the survivin inhibitor MX106-4C. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 73: 101065. PMID 38367548 DOI: 10.1016/j.drup.2024.101065 |
0.466 |
|
| 2023 |
Cao F, Li Y, Ma F, Wu Z, Li Z, Chen ZS, Cheng X, Qin JJ, Dong J. Synthesis and evaluation of WK-X-34 derivatives as P-glycoprotein (P-gp/ABCB1) inhibitors for reversing multidrug resistance. Rsc Medicinal Chemistry. 15: 506-518. PMID 38389882 DOI: 10.1039/d3md00612c |
0.427 |
|
| 2023 |
Teng QX, Lei ZN, Wang JQ, Yang Y, Wu ZX, Acharekar ND, Zhang W, Yoganathan S, Pan Y, Wurpel J, Chen ZS, Fang S. Overexpression of ABCC1 and ABCG2 confers resistance to talazoparib, a poly (ADP-Ribose) polymerase inhibitor. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 73: 101028. PMID 38340425 DOI: 10.1016/j.drup.2023.101028 |
0.548 |
|
| 2023 |
Bin Kanner Y, Teng QX, Ganoth A, Peer D, Wang JQ, Chen ZS, Tsfadia Y. Cytotoxicity and reversal effect of sertraline, fluoxetine, and citalopram on MRP1- and MRP7-mediated MDR. Frontiers in Pharmacology. 14: 1290255. PMID 38026953 DOI: 10.3389/fphar.2023.1290255 |
0.593 |
|
| 2023 |
Gao HL, Cui Q, Wang JQ, Ashby CR, Chen Y, Shen ZX, Chen ZS. The AKT inhibitor, MK-2206, attenuates ABCG2-mediated drug resistance in lung and colon cancer cells. Frontiers in Pharmacology. 14: 1235285. PMID 37521473 DOI: 10.3389/fphar.2023.1235285 |
0.563 |
|
| 2023 |
Wang J, Zeng L, Wu N, Liang Y, Jin J, Fan M, Lai X, Chen ZS, Pan Y, Zeng F, Deng F. Inhibition of phosphoglycerate dehydrogenase induces ferroptosis and overcomes enzalutamide resistance in castration-resistant prostate cancer cells. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 70: 100985. PMID 37423117 DOI: 10.1016/j.drup.2023.100985 |
0.53 |
|
| 2023 |
Lei ZN, Tian Q, Teng QX, Wurpel JND, Zeng L, Pan Y, Chen ZS. Understanding and targeting resistance mechanisms in cancer. Medcomm. 4: e265. PMID 37229486 DOI: 10.1002/mco2.265 |
0.487 |
|
| 2023 |
Xu Y, Wang Z, Zhang L, Gao C, Li F, Li X, Ke Y, Liu HM, Hu Z, Wei L, Chen ZS. Differentiation of imatinib -resistant chronic myeloid leukemia cells with BCR-ABL-T315I mutation induced by Jiyuan Oridonin A. Journal of Cancer. 14: 1182-1194. PMID 37215441 DOI: 10.7150/jca.83219 |
0.385 |
|
| 2023 |
Wen Q, Huang M, Xie J, Liu R, Miao Q, Huang J, Zhang J, Lyu W, Qi M, Wu C, Qi Q, Zhang Z, Deng R, Wang C, Chen ZS, et al. lncRNA SYTL5-OT4 promotes vessel co-option by inhibiting the autophagic degradation of ASCT2. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 69: 100975. PMID 37207473 DOI: 10.1016/j.drup.2023.100975 |
0.397 |
|
| 2023 |
Zhang DM, Shu C, Chen JJ, Sodani K, Wang J, Bhatnagar J, Lan P, Ruan ZX, Xiao ZJ, Ambudkar SV, Chen WM, Chen ZS, Ye WC. Correction to "BBA, a Derivative of 23-Hydroxybetulinic Acid, Potently Reverses ABCB1-Mediated Drug Resistance and ". Molecular Pharmaceutics. 20: 3249. PMID 37183880 DOI: 10.1021/acs.molpharmaceut.3c00215 |
0.781 |
|
| 2023 |
Gao C, Zhang L, Xu Y, Ma X, Chen P, Chen ZS, Wei L. I13 overrides resistance mediated by the T315I mutation in chronic myeloid leukemia by direct BCR-ABL inhibition. Frontiers in Pharmacology. 14: 1183052. PMID 37124196 DOI: 10.3389/fphar.2023.1183052 |
0.348 |
|
| 2023 |
Lin R, Zhang L, Ye B, Wang Y, Li YD, Jason H, Liu W, Hu P, Chen J, Chen ZS, Chen Z. A multi-functional nano-system combining PI3K-110α/β inhibitor overcomes P-glycoprotein mediated MDR and improves anti-cancer efficiency. Cancer Letters. 216181. PMID 37086953 DOI: 10.1016/j.canlet.2023.216181 |
0.422 |
|
| 2023 |
Bo L, Wang Y, Li Y, Wurpel JND, Huang Z, Chen ZS. The Battlefield of Chemotherapy in Pediatric Cancers. Cancers. 15. PMID 37046624 DOI: 10.3390/cancers15071963 |
0.351 |
|
| 2023 |
Ye GJ, Cai CY, Dong XD, Wu ZX, Teng QX, Wang JQ, Chen ZS, Wang B. Design, synthesis, and biological evaluation of phenylurea indole derivatives as ABCG2 inhibitors. Bioorganic Chemistry. 135: 106481. PMID 36966672 DOI: 10.1016/j.bioorg.2023.106481 |
0.382 |
|
| 2023 |
Liu L, Chen C, Liu P, Li J, Pang Z, Zhu J, Lin Z, Zhou H, Xie Y, Lan T, Chen ZS, Zeng Z, Fang W. MYH10 Combines with MYH9 to Recruit USP45 by Deubiquitinating Snail and Promotes Serous Ovarian Cancer Carcinogenesis, Progression, and Cisplatin Resistance. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2203423. PMID 36929633 DOI: 10.1002/advs.202203423 |
0.403 |
|
| 2023 |
Shi ZD, Pang K, Wu ZX, Dong Y, Hao L, Qin JX, Wang W, Chen ZS, Han CH. Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies. Signal Transduction and Targeted Therapy. 8: 113. PMID 36906600 DOI: 10.1038/s41392-023-01383-x |
0.302 |
|
| 2023 |
Xuan J, Feng W, Wang J, Wang R, Zhang B, Bo L, Chen ZS, Yang H, Sun L. Antimicrobial peptides for combating drug-resistant bacterial infections. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 68: 100954. PMID 36905712 DOI: 10.1016/j.drup.2023.100954 |
0.354 |
|
| 2023 |
Cai CY, Teng QX, Murakami M, Ambudkar SV, Chen ZS, Korlipara VL. Design, Synthesis and Biological Evaluation of Quinazolinamine Derivatives as Breast Cancer Resistance Protein and P-Glycoprotein Inhibitors with Improved Metabolic Stability. Biomolecules. 13. PMID 36830622 DOI: 10.3390/biom13020253 |
0.489 |
|
| 2023 |
Chen XY, Li YD, Xie Y, Cao LQ, Ashby CR, Zhao H, Chen ZS. Nivolumab and relatlimab for the treatment of melanoma. Drugs of Today (Barcelona, Spain : 1998). 59: 91-104. PMID 36811409 DOI: 10.1358/dot.2023.59.2.3509756 |
0.327 |
|
| 2023 |
Jin J, Xie Y, Zhang JS, Wang JQ, Dai SJ, He WF, Li SY, Ashby CR, Chen ZS, He Q. Sunitinib resistance in renal cell carcinoma: From molecular mechanisms to predictive biomarkers. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 67: 100929. PMID 36739809 DOI: 10.1016/j.drup.2023.100929 |
0.412 |
|
| 2022 |
Zhang L, Ye B, Chen Z, Chen ZS. Progress in the studies on the molecular mechanisms associated with multidrug resistance in cancers. Acta Pharmaceutica Sinica. B. 13: 982-997. PMID 36970215 DOI: 10.1016/j.apsb.2022.10.002 |
0.457 |
|
| 2022 |
Qin S, Zhang Z, Huang Z, Luo Y, Weng N, Li B, Tang Y, Zhou L, Jiang J, Lu Y, Shao J, Xie N, Nice EC, Chen ZS, Zhang J, et al. CCT251545 enhances drug delivery and potentiates chemotherapy in multidrug-resistant cancers by Rac1-mediated macropinocytosis. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 66: 100906. PMID 36565657 DOI: 10.1016/j.drup.2022.100906 |
0.536 |
|
| 2022 |
Fan J, To KKW, Chen ZS, Fu L. ABC transporters affects tumor immune microenvironment to regulate cancer immunotherapy and multidrug resistance. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 66: 100905. PMID 36463807 DOI: 10.1016/j.drup.2022.100905 |
0.524 |
|
| 2022 |
Yang Q, Xu J, Gu J, Shi H, Zhang J, Zhang J, Chen ZS, Fang X, Zhu T, Zhang X. Extracellular Vesicles in Cancer Drug Resistance: Roles, Mechanisms, and Implications. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2201609. PMID 36253096 DOI: 10.1002/advs.202201609 |
0.482 |
|
| 2022 |
Wang X, Jiang W, Du Y, Zhu D, Zhang J, Fang C, Yan F, Chen ZS. Targeting feedback activation of signaling transduction pathways to overcome drug resistance in cancer. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 65: 100884. PMID 36252360 DOI: 10.1016/j.drup.2022.100884 |
0.355 |
|
| 2022 |
Zhang H, Bian S, Xu Z, Gao M, Wang H, Zhang J, Zhang M, Ke Y, Wang W, Chen ZS, Xu H. The effect and mechanistic study of encequidar on reversing the resistance of SW620/AD300 cells to doxorubicin. Biochemical Pharmacology. 115258. PMID 36179932 DOI: 10.1016/j.bcp.2022.115258 |
0.538 |
|
| 2022 |
Gupta P, Li H, Zhang GN, Barbuti AM, Yang Y, Lin PH, Cai C, Tan T, Ma J, Chen ZS. MG53 inhibits cellular proliferation and tumor progression in colorectal carcinoma. International Journal of Biological Sciences. 18: 5221-5229. PMID 36147477 DOI: 10.7150/ijbs.67869 |
0.48 |
|
| 2022 |
Zhao M, Duan Y, Wang J, Liu Y, Zhao Y, Wang H, Zhang L, Chen ZS, Hu Z, Wei L. Histone Deacetylase Inhibitor I3 Induces the Differentiation of Acute Myeloid Leukemia Cells with (8; 21) or MLL Gene Translocation and Leukemic Stem-Like Cells. Journal of Oncology. 2022: 3345536. PMID 36072977 DOI: 10.1155/2022/3345536 |
0.315 |
|
| 2022 |
Narayanan S, Teng QX, Wu ZX, Nazim U, Karadkhelkar N, Acharekar N, Yoganathan S, Mansoor N, Ping FF, Chen ZS. Anticancer effect of Indanone-based thiazolyl hydrazone derivative on p53 mutant colorectal cancer cell lines: An and study. Frontiers in Oncology. 12: 949868. PMID 35992866 DOI: 10.3389/fonc.2022.949868 |
0.342 |
|
| 2022 |
Wang SQ, Teng QX, Wang S, Lei ZN, Hu HH, Lv HF, Chen BB, Wang JZ, Shi XJ, Xu WF, Liu HM, Chen XB, Chen ZS, Yu B. Preclinical studies of the triazolo[1,5-]pyrimidine derivative WS-716 as a highly potent, specific and orally active P-glycoprotein (P-gp) inhibitor. Acta Pharmaceutica Sinica. B. 12: 3263-3280. PMID 35967279 DOI: 10.1016/j.apsb.2022.03.023 |
0.489 |
|
| 2022 |
Zhu H, Tan Y, He C, Liu Y, Duan Y, Zhu W, Zheng T, Li D, Xu J, Yang DH, Chen ZS, Xu S. Discovery of a Novel Vascular Disrupting Agent Inhibiting Tubulin Polymerization and HDACs with Potent Antitumor Effects. Journal of Medicinal Chemistry. PMID 35926141 DOI: 10.1021/acs.jmedchem.2c00681 |
0.317 |
|
| 2022 |
Huang M, Lin Y, Wang C, Deng L, Chen M, Assaraf YG, Chen ZS, Ye W, Zhang D. New insights into antiangiogenic therapy resistance in cancer: Mechanisms and therapeutic aspects. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 64: 100849. PMID 35842983 DOI: 10.1016/j.drup.2022.100849 |
0.333 |
|
| 2022 |
Chong X, Chen J, Zheng N, Zhou Z, Hai Y, Chen S, Zhang Y, Yu Q, Yu S, Chen Z, Bao W, Quan M, Chen ZS, Zhan Y, Gao Y. PIK3CA mutations-mediated downregulation of circLHFPL2 inhibits colorectal cancer progression via upregulating PTEN. Molecular Cancer. 21: 118. PMID 35619132 DOI: 10.1186/s12943-022-01531-x |
0.319 |
|
| 2022 |
Zou Y, Zheng S, Xie X, Ye F, Hu X, Tian Z, Yan SM, Yang L, Kong Y, Tang Y, Tian W, Xie J, Deng X, Zeng Y, Chen ZS, et al. N6-methyladenosine regulated FGFR4 attenuates ferroptotic cell death in recalcitrant HER2-positive breast cancer. Nature Communications. 13: 2672. PMID 35562334 DOI: 10.1038/s41467-022-30217-7 |
0.353 |
|
| 2022 |
Gu J, Huang W, Wang X, Zhang J, Tao T, Zheng Y, Liu S, Yang J, Chen ZS, Cai CY, Li J, Wang H, Fan Y. Hsa-miR-3178/RhoB/PI3K/Akt, a novel signaling pathway regulates ABC transporters to reverse gemcitabine resistance in pancreatic cancer. Molecular Cancer. 21: 112. PMID 35538494 DOI: 10.1186/s12943-022-01587-9 |
0.475 |
|
| 2022 |
Cui Q, Liang XL, Wang JQ, Zhang JY, Chen ZS. Therapeutic implication of carbon monoxide in drug resistant cancers. Biochemical Pharmacology. 201: 115061. PMID 35489394 DOI: 10.1016/j.bcp.2022.115061 |
0.5 |
|
| 2022 |
Zhang L, Li Y, Hu C, Chen Y, Chen Z, Chen ZS, Zhang JY, Fang S. CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells. Molecular Cancer. 21: 103. PMID 35459184 DOI: 10.1186/s12943-022-01524-w |
0.507 |
|
| 2022 |
Zhang L, Ye B, Lin Y, Li YD, Wang JQ, Chen Z, Ping FF, Chen ZS. Ribociclib Inhibits P-gp-Mediated Multidrug Resistance in Human Epidermoid Carcinoma Cells. Frontiers in Pharmacology. 13: 867128. PMID 35450042 DOI: 10.3389/fphar.2022.867128 |
0.451 |
|
| 2022 |
Fu H, Wu ZX, Lei ZN, Teng QX, Yang Y, Ashby CR, Lei Y, Lian Y, Chen ZS. The Resistance of Cancer Cells to Palbociclib, a Cyclin-Dependent Kinase 4/6 Inhibitor, is Mediated by the ABCB1 Transporter. Frontiers in Pharmacology. 13: 861642. PMID 35350768 DOI: 10.3389/fphar.2022.861642 |
0.552 |
|
| 2022 |
Dong XD, Zhang M, Cai CY, Teng QX, Wang JQ, Fu YG, Cui Q, Patel K, Wang DT, Chen ZS. Overexpression of ABCB1 Associated With the Resistance to the KRAS-G12C Specific Inhibitor ARS-1620 in Cancer Cells. Frontiers in Pharmacology. 13: 843829. PMID 35281897 DOI: 10.3389/fphar.2022.843829 |
0.55 |
|
| 2022 |
Ma XY, Zhao M, Li YD, Chen Y, Wei L, Chen ZS. Research progress in overcoming ibrutinib drug resistance. Drugs of Today (Barcelona, Spain : 1998). 58: 85-94. PMID 35188143 DOI: 10.1358/dot.2022.58.2.3360405 |
0.457 |
|
| 2022 |
Song H, Liu D, Wang L, Liu K, Chen C, Wang L, Ren Y, Ju B, Zhong F, Jiang X, Wang G, Chen ZS, Zou C. Methyltransferase like 7B is a potential therapeutic target for reversing EGFR-TKIs resistance in lung adenocarcinoma. Molecular Cancer. 21: 43. PMID 35144642 DOI: 10.1186/s12943-022-01519-7 |
0.32 |
|
| 2022 |
Yang Y, Teng QX, Wu ZX, Wang JQ, Lei ZN, Lusvarghi S, Ambudkar SV, Ji N, Chen ZS. PBK/TOPK inhibitor OTS964 resistance is mediated by ABCB1-dependent transport function in cancer: in vitro and in vivo study. Molecular Cancer. 21: 40. PMID 35135547 DOI: 10.1186/s12943-022-01512-0 |
0.535 |
|
| 2022 |
Shi ZD, Hao L, Han XX, Wu ZX, Pang K, Dong Y, Qin JX, Wang GY, Zhang XM, Xia T, Liang Q, Zhao Y, Li R, Zhang SQ, Zhang JH, ... ... Chen ZS, et al. Targeting HNRNPU to overcome cisplatin resistance in bladder cancer. Molecular Cancer. 21: 37. PMID 35130920 DOI: 10.1186/s12943-022-01517-9 |
0.459 |
|
| 2022 |
Liu K, Chen Y, Shi XB, Xing ZH, He ZJ, Wang ST, Li YC, Liu WJ, Zhang PW, Yu ZZ, Mo XM, Shi XY, Chen ZS, Shi Z. Inhibiting the Activity of ABCG2 by KU55933 in Colorectal Cancer. Recent Patents On Anti-Cancer Drug Discovery. PMID 35023460 DOI: 10.2174/1574892817666220112100036 |
0.412 |
|
| 2021 |
Wu ZX, Teng QX, Yang Y, Acharekar N, Wang JQ, He M, Yoganathan S, Lin J, Wang J, Chen ZS. MET inhibitor tepotinib antagonizes multidrug resistance mediated by ABCG2 transporter: and study. Acta Pharmaceutica Sinica. B. 12: 2609-2618. PMID 35646541 DOI: 10.1016/j.apsb.2021.12.018 |
0.633 |
|
| 2021 |
Patel H, Wu ZX, Chen Y, Bo L, Chen ZS. Drug resistance: from bacteria to cancer. Molecular Biomedicine. 2: 27. PMID 35006446 DOI: 10.1186/s43556-021-00041-4 |
0.53 |
|
| 2021 |
Lei ZN, Teng QX, Wu ZX, Ping FF, Song P, Wurpel JND, Chen ZS. Overcoming multidrug resistance by knockout of ABCB1 gene using CRISPR/Cas9 system in SW620/Ad300 colorectal cancer cells. Medcomm. 2: 765-777. PMID 34977876 DOI: 10.1002/mco2.106 |
0.492 |
|
| 2021 |
Peng X, Zhang S, Jiao W, Zhong Z, Yang Y, Claret FX, Elkabets M, Wang F, Wang R, Zhong Y, Chen ZS, Kong D. Hydroxychloroquine synergizes with the PI3K inhibitor BKM120 to exhibit antitumor efficacy independent of autophagy. Journal of Experimental & Clinical Cancer Research : Cr. 40: 374. PMID 34844627 DOI: 10.1186/s13046-021-02176-2 |
0.33 |
|
| 2021 |
Wang JQ, Cui Q, Lei ZN, Teng QX, Ji N, Lin L, Liu Z, Chen ZS. Insights on the structure-function relationship of human multidrug resistance protein 7 (MRP7/ABCC10) from molecular dynamics simulations and docking studies. Medcomm. 2: 221-235. PMID 34766143 DOI: 10.1002/mco2.65 |
0.472 |
|
| 2021 |
Wang S, Wang SQ, Teng QX, Lei ZN, Chen ZS, Chen XB, Liu HM, Yu B. Discovery of the Triazolo[1,5-]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance. Journal of Medicinal Chemistry. PMID 34723530 DOI: 10.1021/acs.jmedchem.1c01498 |
0.54 |
|
| 2021 |
Wang JQ, Wu ZX, Yang Y, Li JS, Yang DH, Fan YF, Chen ZS. Establishment and Characterization of a Novel Multidrug Resistant Human Ovarian Cancer Cell Line With Heterogenous MRP7 Overexpression. Frontiers in Oncology. 11: 731260. PMID 34631561 DOI: 10.3389/fonc.2021.731260 |
0.57 |
|
| 2021 |
Li J, Zeng L, Wang Z, Chen H, Fang S, Wang J, Cai CY, Xing E, Liao X, Li ZW, Jr CRA, Chen ZS, Chao H, Pan Y. Cycloruthenated Self-Assembly with Metabolic Inhibition to Efficiently Overcome Multidrug Resistance in Cancers. Advanced Materials (Deerfield Beach, Fla.). e2100245. PMID 34613635 DOI: 10.1002/adma.202100245 |
0.5 |
|
| 2021 |
Liu W, Zhang SX, Ai B, Pan HF, Zhang D, Jiang Y, Hu LH, Sun LL, Chen ZS, Lin LZ. Ginsenoside Rg3 Promotes Cell Growth Through Activation of mTORC1. Frontiers in Cell and Developmental Biology. 9: 730309. PMID 34589493 DOI: 10.3389/fcell.2021.730309 |
0.305 |
|
| 2021 |
Narayanan S, Fan YF, Gujarati NA, Teng QX, Wang JQ, Cai CY, Yang Y, Chintalapati AJ, Lei Y, Korlipara VL, Chen ZS. VKNG-1 Antagonizes ABCG2-Mediated Multidrug Resistance via p-AKT and Bcl-2 Pathway in Colon Cancer: In Vitro and In Vivo Study. Cancers. 13. PMID 34572902 DOI: 10.3390/cancers13184675 |
0.609 |
|
| 2021 |
Yuan S, Wang B, Dai QQ, Zhang XN, Zhang JY, Zuo JH, Liu H, Chen ZS, Li GB, Wang S, Liu HM, Yu B. Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors. Journal of Medicinal Chemistry. PMID 34546748 DOI: 10.1021/acs.jmedchem.1c01452 |
0.361 |
|
| 2021 |
Su Z, Dong S, Zhao SC, Liu K, Tan Y, Jiang X, Assaraf YG, Qin B, Chen ZS, Zou C. Novel nanomedicines to overcome cancer multidrug resistance. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 58: 100777. PMID 34481195 DOI: 10.1016/j.drup.2021.100777 |
0.487 |
|
| 2021 |
Wang JQ, Wu ZX, Yang Y, Teng QX, Li YD, Lei ZN, Jani KA, Kaushal N, Chen ZS. ATP-binding cassette (ABC) transporters in cancer: A review of recent updates. Journal of Evidence-Based Medicine. PMID 34388310 DOI: 10.1111/jebm.12434 |
0.472 |
|
| 2021 |
Khare T, Anand U, Dey A, Assaraf YG, Chen ZS, Liu Z, Kumar V. Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens. Frontiers in Pharmacology. 12: 720726. PMID 34366872 DOI: 10.3389/fphar.2021.720726 |
0.438 |
|
| 2021 |
Wu ZX, Yang Y, Wang JQ, Narayanan S, Lei ZN, Teng QX, Zeng L, Chen ZS. Overexpression of ABCG2 Confers Resistance to MLN7243, a Ubiquitin-Activating Enzyme (UAE) Inhibitor. Frontiers in Cell and Developmental Biology. 9: 697927. PMID 34336849 DOI: 10.3389/fcell.2021.697927 |
0.638 |
|
| 2021 |
Narayanan S, Wu ZX, Wang JQ, Ma H, Acharekar N, Koya J, Yoganathan S, Fang S, Chen ZS, Pan Y. The Spleen Tyrosine Kinase Inhibitor, Entospletinib (GS-9973) Restores Chemosensitivity in Lung Cancer Cells by Modulating ABCG2-mediated Multidrug Resistance. International Journal of Biological Sciences. 17: 2652-2665. PMID 34326700 DOI: 10.7150/ijbs.61229 |
0.591 |
|
| 2021 |
Wang JQ, Wang B, Ma LY, Shi Z, Liu HM, Liu Z, Chen ZS. Enhancement of anticancer drug sensitivity in multidrug resistance cells overexpressing ATP-binding cassette (ABC) transporter ABCC10 by CP55, a synthetic derivative of 5-cyano-6-phenylpyrimidin. Experimental Cell Research. 112728. PMID 34246653 DOI: 10.1016/j.yexcr.2021.112728 |
0.622 |
|
| 2021 |
Hussein NA, Malla S, Pasternak MA, Terrero D, Brown NG, Ashby CR, Assaraf YG, Chen ZS, Tiwari AK. The role of endolysosomal trafficking in anticancer drug resistance. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 57: 100769. PMID 34217999 DOI: 10.1016/j.drup.2021.100769 |
0.526 |
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| 2021 |
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Cui Q, Wang JQ, Assaraf YG, Ren L, Gupta P, Wei L, Ashby CR, Yang DH, Chen ZS. Modulating ROS to overcome multidrug resistance in cancer. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 41: 1-25. PMID 30471641 DOI: 10.1016/J.Drup.2018.11.001 |
0.557 |
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| 2018 |
Ji N, Yang Y, Lei ZN, Cai CY, Wang JQ, Gupta P, Xian X, Yang DH, Kong D, Chen ZS. Ulixertinib (BVD-523) antagonizes ABCB1- and ABCG2-mediated chemotherapeutic drug resistance. Biochemical Pharmacology. 158: 274-285. PMID 30431011 DOI: 10.1016/J.Bcp.2018.10.028 |
0.684 |
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| 2018 |
Ji N, Yang Y, Cai CY, Lei ZN, Wang JQ, Gupta P, Teng QX, Chen ZS, Kong D, Yang DH. VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters. Frontiers in Pharmacology. 9: 1236. PMID 30425643 DOI: 10.3389/Fphar.2018.01236 |
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| 2018 |
Chang L, Xiao M, Yang L, Wang S, Wang SQ, Bender A, Hu A, Chen ZS, Yu B, Liu HM. Discovery of a non-toxic [1,2,4]triazolo[1,5-a]pyrimidin-7-one (WS-10) that modulates ABCB1-mediated multidrug resistance (MDR). Bioorganic & Medicinal Chemistry. PMID 30401501 DOI: 10.1016/J.Bmc.2018.10.027 |
0.624 |
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| 2018 |
Zhang YK, Wang YJ, Lei ZN, Zhang GN, Zhang XY, Wang DS, Al Rihani SB, Shukla S, Ambudkar SV, Kaddoumi A, Shi Z, Chen ZS. Regorafenib antagonizes BCRP-mediated multidrug resistance in colon cancer. Cancer Letters. PMID 30392788 DOI: 10.1016/J.Canlet.2018.10.032 |
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| 2018 |
De Vera AA, Gupta P, Lei Z, Liao D, Narayanan S, Teng Q, Reznik SE, Chen ZS. Immuno-oncology agent IPI-549 is a modulator of P-glycoprotein (P-gp, MDR1, ABCB1)-mediated multidrug resistance (MDR) in cancer: In vitro and in vivo. Cancer Letters. PMID 30391357 DOI: 10.1016/J.Canlet.2018.10.020 |
0.506 |
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| 2018 |
Zhang W, Fan YF, Cai CY, Wang JQ, Teng QX, Lei ZN, Zeng L, Gupta P, Chen ZS. Olmutinib (BI1482694/HM61713), a Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Reverses ABCG2-Mediated Multidrug Resistance in Cancer Cells. Frontiers in Pharmacology. 9: 1097. PMID 30356705 DOI: 10.3389/Fphar.2018.01097 |
0.706 |
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| 2018 |
Ji N, Yang Y, Cai CY, Lei ZN, Wang JQ, Gupta P, Shukla S, Ambudkar SV, Kong D, Chen ZS. Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells. Cancer Letters. PMID 30315846 DOI: 10.1016/J.Canlet.2018.10.007 |
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| 2018 |
Xiao M, Xue Y, Wu Z, Lei ZN, Wang J, Chen ZS, Li W. Design, synthesis and biological evaluation of selective survivin inhibitors. Journal of Biomedical Research. PMID 30174320 DOI: 10.7555/JBR.31.20160173 |
0.42 |
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| 2018 |
Chang L, Xiao M, Yang L, Wang S, Wang SQ, Bender A, Hu A, Chen ZS, Yu B, Liu HM. Discovery of a non-toxic [1,2,4]triazolo[1,5-a]pyrimidin-7-one (WS-10) that modulates ABCB1-mediated multidrug resistance (MDR). Bioorganic & Medicinal Chemistry. PMID 30150104 DOI: 10.1016/j.bmc.2018.08.021 |
0.55 |
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| 2018 |
Guan R, Chen Y, Zeng L, Rees TW, Jin C, Huang J, Chen ZS, Ji L, Chao H. Oncosis-inducing cyclometalated iridium(iii) complexes. Chemical Science. 9: 5183-5190. PMID 29997872 DOI: 10.1039/C8Sc01142G |
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| 2018 |
Wang B, Ma LY, Wang JQ, Lei ZN, Gupta P, Zhao YD, Li ZH, Liu Y, Zhang XH, Li YN, Zhao B, Chen ZS, Liu HM. Discovery of 5-cyano-6-phenylpyrimidin derivatives containing an acylurea moiety as orally bioavailable reversal agents against P-glycoprotein-mediated mutidrug resistance. Journal of Medicinal Chemistry. PMID 29975529 DOI: 10.1021/Acs.Jmedchem.8B00335 |
0.6 |
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| 2018 |
Zhang GN, Zhang YK, Wang YJ, Gupta P, Ashby CR, Alqahtani S, Deng T, Bates SE, Kaddoumi A, Wurpel JND, Lei YX, Chen ZS. Epidermal growth factor receptor (EGFR) inhibitor PD153035 reverses ABCG2-mediated multidrug resistance in non-small cell lung cancer: In vitro and in vivo. Cancer Letters. PMID 29518481 DOI: 10.1016/J.Canlet.2018.02.040 |
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| 2018 |
Wang Q, Arnst KE, Xue Y, Lei ZN, Ma D, Chen ZS, Miller DD, Li W. Synthesis and biological evaluation of indole-based UC-112 analogs as potent and selective survivin inhibitors. European Journal of Medicinal Chemistry. 149: 211-224. PMID 29501942 DOI: 10.1016/J.Ejmech.2018.02.045 |
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| 2018 |
Gupta P, Zhang YK, Zhang XY, Wang YJ, Lu KW, Hall T, Peng R, Yang DH, Xie N, Chen ZS. Voruciclib, a Potent CDK4/6 Inhibitor, Antagonizes ABCB1 and ABCG2-Mediated Multi-Drug Resistance in Cancer Cells. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 45: 1515-1528. PMID 29486476 DOI: 10.1159/000487578 |
0.69 |
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| 2018 |
Fan YF, Zhang W, Zeng L, Lei ZN, Cai CY, Gupta P, Yang DH, Cui Q, Qin ZD, Chen ZS, Trombetta LD. Dacomitinib antagonizes multidrug resistance (MDR) in cancer cells by inhibiting the efflux activity of ABCB1 and ABCG2 transporters. Cancer Letters. PMID 29331420 DOI: 10.1016/J.Canlet.2018.01.021 |
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| 2018 |
Gupta P, Barbuti AM, Wang D, Cui Q, Chen Z. Icotinib improves progression free survival in epidermal growth factor receptor positive non-small cell lung cancer patients Translational Cancer Research. 7. DOI: 10.21037/18592 |
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| 2018 |
Barbuti AM, Chen Z. Abstract 4899: Establishment and characterization of SN-38 resistant metastatic colorectal cancer cells (SW620/SN100) reveals an ABCG2 (BCRP) transport mediated resistance Cancer Research. 78: 4899-4899. DOI: 10.1158/1538-7445.Am2018-4899 |
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| 2018 |
Gupta P, Zhang G, Barbuti AM, Ding K, Pan J, Druker BJ, Chen Z. Abstract 1980: S116836 overcomes BCR-ABL T315I mutation mediated imatinib resistance in chronic myeloid leukemia Cancer Research. 78: 1980-1980. DOI: 10.1158/1538-7445.Am2018-1980 |
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| 2018 |
Chang L, Xiao M, Yang L, Wang S, Wang S, Bender A, Hu A, Chen Z, Yu B, Liu H. Erratum to “Discovery of a Non-toxic [1,2,4] Triazolo[1,5-A] Pyrimidin-7-One (WS-10) that Modulates ABCB1-Mediated Multidrug Resistance (MDR)” [Bioorganic & Medicinal Chemistry 26/18 (2018) 5006–5017] Bioorganic & Medicinal Chemistry. 26: 5973. DOI: 10.1016/J.Bmc.2018.10.026 |
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| 2017 |
Patel BA, Abel B, Barbuti AM, Velagapudi UK, Chen ZS, Ambudkar SV, Talele TT. Comprehensive Synthesis of Amino Acid-derived Thiazole Peptidomimetic Analogues to Understand Enigmatic Drug/Substrate-Binding Site of P-glycoprotein. Journal of Medicinal Chemistry. PMID 29251928 DOI: 10.1021/Acs.Jmedchem.7B01340 |
0.42 |
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| 2017 |
Li J, Kumar P, Anreddy N, Zhang YK, Wang YJ, Chen Y, Talele TT, Gupta K, Trombetta LD, Chen ZS. Quizartinib (AC220) reverses ABCG2-mediated multidrug resistance: In vitro and in vivo studies. Oncotarget. 8: 93785-93799. PMID 29212189 DOI: 10.18632/Oncotarget.21078 |
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| 2017 |
Fan HB, Zhai ZY, Li XG, Gao CQ, Yan HC, Chen ZS, Wang XQ. CDX2 Stimulates the Proliferation of Porcine Intestinal Epithelial Cells by Activating the mTORC1 and Wnt/β-Catenin Signaling Pathways. International Journal of Molecular Sciences. 18. PMID 29156556 DOI: 10.3390/Ijms18112447 |
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| 2017 |
Wang B, Zhao B, Chen ZS, Pang LP, Zhao YD, Guo Q, Zhang XH, Liu Y, Liu GY, Hao-Zhang, Zhang XY, Ma LY, Liu HM. Exploration of 1,2,3-triazole-pyrimidine hybrids as potent reversal agents against ABCB1-mediated multidrug resistance. European Journal of Medicinal Chemistry. PMID 29126726 DOI: 10.1016/J.Ejmech.2017.10.041 |
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| 2017 |
Romu AA, Lei Z, Zhou B, Chen ZS, Korlipara V. Design, synthesis and biological evaluation of WZ4002 analogues as EGFR inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 28974338 DOI: 10.1016/J.Bmcl.2017.09.048 |
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| 2017 |
Zhang YK, Dai C, Yuan CG, Wu HC, Xiao Z, Lei ZN, Yang DH, Le XC, Fu L, Chen ZS. Establishment and characterization of arsenic trioxide resistant KB/ATO cells. Acta Pharmaceutica Sinica. B. 7: 564-570. PMID 28924550 DOI: 10.1016/j.apsb.2017.04.001 |
0.55 |
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| 2017 |
Gujarati NA, Zeng L, Gupta P, Chen ZS, Korlipara VL. Design, synthesis and biological evaluation of benzamide and phenyltetrazole derivatives with amide and urea linkers as BCRP inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 28916341 DOI: 10.1016/J.Bmcl.2017.09.009 |
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| 2017 |
Xu S, Yao H, Hu M, Li D, Zhu Z, Xie W, Yao H, Wu L, Chen ZS, Xu J. 6,7-Seco-ent-Kauranoids Derived from Oridonin as Potential Anticancer Agents. Journal of Natural Products. PMID 28901767 DOI: 10.1021/Acs.Jnatprod.7B00057 |
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| 2017 |
Zeng L, Gupta P, Chen Y, Wang E, Ji L, Chao H, Chen ZS. The development of anticancer ruthenium(ii) complexes: from single molecule compounds to nanomaterials. Chemical Society Reviews. PMID 28654103 DOI: 10.1039/C7Cs00195A |
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| 2017 |
Li YJ, Lei YH, Yao N, Wang CR, Hu N, Ye WC, Zhang DM, Chen ZS. Autophagy and multidrug resistance in cancer. Chinese Journal of Cancer. 36: 52. PMID 28646911 DOI: 10.1186/S40880-017-0219-2 |
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| 2017 |
Huang BY, Zeng Y, Li YJ, Huang XJ, Hu N, Yao N, Chen MF, Yang ZG, Chen ZS, Zhang DM, Zeng CQ. Uncaria alkaloids reverse ABCB1-mediated cancer multidrug resistance. International Journal of Oncology. PMID 28534954 DOI: 10.3892/ijo.2017.4005 |
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| 2017 |
Patel A, Li TW, Anreddy N, Wang DS, Sodani K, Gadhia S, Kathawala R, Yang DH, Cheng C, Chen ZS. Suppression of ABCG2 mediated MDR in vitro and in vivo by a novel inhibitor of ABCG2 drug transport. Pharmacological Research. PMID 28455266 DOI: 10.1016/J.Phrs.2017.04.025 |
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| 2017 |
Wen Y, Zhao RQ, Zhang YK, Gupta P, Fu LX, Tang AZ, Liu BM, Chen ZS, Yang DH, Liang G. Effect of Y6, an epigallocatechingallate derivative, on reversing doxorubicin drug resistance in human hepatocellular carcinoma cells. Oncotarget. PMID 28423656 DOI: 10.18632/Oncotarget.15964 |
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| 2017 |
Wang YJ, Zhang YK, Zhang GN, Al Rihani SB, Wei MN, Gupta P, Zhang XY, Shukla S, Ambudkar SV, Kaddoumi A, Shi Z, Chen ZS. Regorafenib overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter in colorectal cancer: In vitro and in vivo study. Cancer Letters. PMID 28302530 DOI: 10.1016/J.Canlet.2017.03.011 |
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| 2017 |
Gupta P, Xie M, Narayanan S, Wang YJ, Wang XQ, Yuan T, Wang Z, Yang DH, Chen ZS. GSK1904529A, a Potent IGF-IR Inhibitor, Reverses MRP1-mediated Multidrug Resistance. Journal of Cellular Biochemistry. PMID 28266043 DOI: 10.1002/Jcb.25975 |
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| 2017 |
Zhang H, Patel AS, Wang YJ, Zhang YK, Kathawala RJ, Qiu LH, Patel BA, Huang LH, Shukla S, Yang DH, Ambudkar SV, Fu L, Chen ZS. The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors. Molecular Cancer Therapeutics. PMID 28265007 DOI: 10.1158/1535-7163.Mct-16-0511 |
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| 2017 |
Zhang YK, Zhang XY, Zhang GN, Wang YJ, Xu H, Zhang D, Shukla S, Liu L, Yang DH, Ambudkar SV, Chen ZS. Selective Reversal of BCRP-mediated MDR by VEGFR-2 inhibitor ZM323881. Biochemical Pharmacology. PMID 28242251 DOI: 10.1016/J.Bcp.2017.02.019 |
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| 2017 |
Wang YJ, Patel BA, Anreddy N, Zhang YK, Zhang GN, Alqahtani S, Singh S, Shukla S, Kaddoumi A, Ambudkar SV, Talele TT, Chen ZS. Thiazole-valine peptidomimetic (TTT-28) antagonizes multidrug resistance in vitro and in vivo by selectively inhibiting the efflux activity of ABCB1. Scientific Reports. 7: 42106. PMID 28181548 DOI: 10.1038/Srep42106 |
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| 2017 |
Xu S, Yao H, Luo S, Zhang YK, Yang DH, Li D, Wang G, Hu M, Qiu Y, Wu X, Yao H, Xie W, Chen ZS, Xu J. A novel potent anticancer compound optimized from a natural oridonin scaffold induces apoptosis and cell cycle arrest through the mitochondrial pathway. Journal of Medicinal Chemistry. PMID 28165738 DOI: 10.1021/Acs.Jmedchem.6B01652 |
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| 2017 |
Zhang GN, Zhang YK, Wang YJ, Barbuti AM, Zhu XJ, Yu XY, Wen AW, Wurpel JN, Chen ZS. Modulating the function of ATP-binding cassette subfamily G member 2 (ABCG2) inhibitor cabozantinib. Pharmacological Research. PMID 28131876 DOI: 10.1016/J.Phrs.2017.01.024 |
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| 2017 |
Kathawala RJ, Li T, Yang D, Guo HQ, Yang DH, Chen X, Cheng C, Chen ZS. 2-Trifluoromethyl-2-Hydroxypropionamide Derivatives as Novel Reversal Agents of ABCG2 (BCRP)-Mediated Multidrug Resistance: Synthesis and Biological Evaluations. Journal of Cellular Biochemistry. PMID 28120346 DOI: 10.1002/Jcb.25908 |
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| 2017 |
Zhang X, Lei Z, Zhang Y, Wang Y, Gupta P, Zeng L, Xu M, Wang X, Yang D, Chen Z. Abstract 5876: Osimertinib (AZD9291), a mutant-selective EGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells Cancer Research. 77: 5876-5876. DOI: 10.1158/1538-7445.Am2017-5876 |
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| 2017 |
Gupta P, Kathawala R, Wei L, Wang F, Wang X, Druker BJ, Fu L, Chen Z. Abstract 4158: Targeting the imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia through a novel BCR-ABL inhibitor Cancer Research. 77: 4158-4158. DOI: 10.1158/1538-7445.Am2017-4158 |
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| 2017 |
Cai C, Zhai H, Lei Z, Chen B, Du Z, Zhang Y, Wang Y, Wang B, Chen Z. Abstract 4063: Design and synthesis of indole derivatives as ABCG2 mediated resistance reversal agents Cancer Research. 77: 4063-4063. DOI: 10.1158/1538-7445.Am2017-4063 |
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| 2017 |
Wang X, Qiao D, Chen L, Huang L, Xu M, Chen Z, Wang F, Chen Z, Zeng M, Fu L. Abstract 3180: Chemotherapeutical agent triggers transient resistance of cancer cells by promoting ABCB1 intercellular transfer Cancer Research. 77: 3180-3180. DOI: 10.1158/1538-7445.Am2017-3180 |
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| 2017 |
Zhang Y, Wang Y, Zhang G, Zhang W, Wei M, Shi Z, Chen Z. Abstract 1192: Regorafenib (Stivarga®) reverses BCRP-mediated multidrug resistancein vitroandin vivo Cancer Research. 77: 1192-1192. DOI: 10.1158/1538-7445.Am2017-1192 |
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| 2016 |
Whitt JD, Keeton AB, Gary BD, Sklar LA, Sodani K, Chen ZS, Piazza GA. Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletion. Journal of Biomedical Research. 30: 120-133. PMID 28276667 DOI: 10.7555/Jbr.30.20150108 |
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Zhang WJ, Li Y, Wei MN, Chen Y, Qiu JG, Jiang QW, Yang Y, Zheng DW, Qin WM, Huang JR, Wang K, Zhang WJ, Wang YJ, Yang DH, Chen ZS, et al. Synergistic antitumor activity of regorafenib and lapatinib in preclinical models of human colorectal cancer. Cancer Letters. PMID 27864115 DOI: 10.1016/J.Canlet.2016.11.011 |
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Gupta P, Kathawala RJ, Wei L, Wang F, Wang X, Druker BJ, Fu LW, Chen ZS. PBA2, a novel inhibitor of imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia. Cancer Letters. PMID 27720778 DOI: 10.1016/J.Canlet.2016.09.025 |
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Zhang XY, Zhang YK, Wang YJ, Gupta P, Zeng L, Xu M, Wang XQ, Yang DH, Chen ZS. Osimertinib (AZD9291), a Mutant-Selective EGFR Inhibitor, Reverses ABCB1-Mediated Drug Resistance in Cancer Cells. Molecules (Basel, Switzerland). 21. PMID 27649127 DOI: 10.3390/Molecules21091236 |
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Li W, Zhang H, Assaraf YG, Zhao K, Xu X, Xie J, Yang DH, Chen ZS. Overcoming ABC transporter-mediated multidrug resistance: Molecular mechanisms and novel therapeutic drug strategies. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 27: 14-29. PMID 27449595 DOI: 10.1016/J.Drup.2016.05.001 |
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| 2016 |
Zhang YK, Zhang GN, Wang YJ, Patel BA, Talele TT, Yang DH, Chen ZS. Bafetinib (INNO-406) reverses multidrug resistance by inhibiting the efflux function of ABCB1 and ABCG2 transporters. Scientific Reports. 6: 25694. PMID 27157787 DOI: 10.1038/Srep25694 |
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Zheng YC, Yu B, Chen ZS, Liu Y, Liu HM. TCPs: privileged scaffolds for identifying potent LSD1 inhibitors for cancer therapy. Epigenomics. PMID 27102879 DOI: 10.2217/Epi-2015-0002 |
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Xu S, Luo S, Yao H, Cai H, Miao X, Wu F, Yang DH, Wu X, Xie W, Yao H, Chen ZS, Xu J. Probing the Anticancer Action of Oridonin with Fluorescent Analogues: Visualizing Subcellular Localization to Mitochondria. Journal of Medicinal Chemistry. PMID 27089099 DOI: 10.1021/Acs.Jmedchem.6B00408 |
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Jones VS, Huang RY, Chen LP, Chen ZS, Fu L, Huang RP. Cytokines in cancer drug resistance: Cues to new therapeutic strategies. Biochimica Et Biophysica Acta. PMID 26993403 DOI: 10.1016/j.bbcan.2016.03.005 |
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Gupta P, Jani KA, Yang DH, Sadoqi M, Squillante E, Chen ZS. Revisiting the role of nanoparticles as modulators of drug resistance and metabolism in cancer. Expert Opinion On Drug Metabolism & Toxicology. PMID 26799671 DOI: 10.1517/17425255.2016.1145655 |
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Zheng YC, Wang LZ, Zhao LJ, Zhao LJ, Zhan QN, Ma JL, Zhang B, Wang MM, Wang ZR, Li JF, Liu Y, Chen ZS, Shen DD, Liu XQ, Ren M, et al. 1,2,3-Triazole-Dithiocarbamate Hybrids, a Group of Novel Cell Active SIRT1 Inhibitors. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 38: 185-193. PMID 26784898 DOI: 10.1159/000438620 |
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Whitt JD, Keeton AB, Gary BD, Sklar LA, Sodani K, Chen ZS, Piazza GA. Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletion Journal of Biomedical Research. 30: 120-133. DOI: 10.7555/JBR.30.20150108 |
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Zhang G, Zhang Y, Wang Y, Chen Z. Abstract 4684: Modulating the function of multidrug resistance ABCG2 transporter by tyrosine kinases receptor inhibitor cabozantinib Cancer Research. 76: 4684-4684. DOI: 10.1158/1538-7445.Am2016-4684 |
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| 2016 |
Wang Y, Huang Y, Anreddy N, Zhang G, Zhang Y, Xie M, Lin D, Yang D, Zhang M, Chen Z. Abstract 2201: Tea nanoparticle, a safe and biocompatible nanocarrier, greatly potentiates the anticancer activity of doxorubicin Cancer Research. 76: 2201-2201. DOI: 10.1158/1538-7445.Am2016-2201 |
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Barbuti AM, Patel BA, Talele TT, Chen Z. Abstract 2144: Next generation inhibitors to reverse ABCB1 transport mediated multidrug resistance in cancer Cancer Research. 76: 2144-2144. DOI: 10.1158/1538-7445.Am2016-2144 |
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Wang YJ, Huang Y, Anreddy N, Zhang GN, Zhang YK, Xie M, Lin D, Yang DH, Zhang M, Chen ZS. Tea nanoparticle, a safe and biocompatible nanocarrier, greatly potentiates the anticancer activity of doxorubicin. Oncotarget. PMID 26716507 DOI: 10.18632/Oncotarget.6711 |
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Barbuti AM, Chen ZS. Paclitaxel Through the Ages of Anticancer Therapy: Exploring Its Role in Chemoresistance and Radiation Therapy. Cancers. 7: 2360-2371. PMID 26633515 DOI: 10.3390/Cancers7040897 |
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Sui H, Zhou LH, Zhang YL, Huang JP, Liu X, Ji Q, Fu XL, Wen HT, Chen ZS, Deng WL, Zhu HR, Li Q. Evodiamine Suppresses ABCG2 Mediated Drug Resistance by Inhibiting p50/NF-κB Pathway in Colorectal Cancer. Journal of Cellular Biochemistry. PMID 26590365 DOI: 10.1002/Jcb.25451 |
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Zhuo Z, Hu J, Yang X, Chen M, Lei X, Deng L, Yao N, Peng Q, Chen Z, Ye W, Zhang D. Ailanthone Inhibits Huh7 Cancer Cell Growth via Cell Cycle Arrest and Apoptosis In Vitro and In Vivo. Scientific Reports. 5: 16185. PMID 26525771 DOI: 10.1038/Srep16185 |
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| 2015 |
Anreddy N, Patel A, Zhang YK, Wang YJ, Shukla S, Kathawala RJ, Kumar P, Gupta P, Ambudkar SV, Wurpel JN, Chen ZS, Guo H. A-803467, a tetrodotoxin-resistant sodium channel blocker, modulates ABCG2-mediated MDR in vitro and in vivo. Oncotarget. PMID 26515463 DOI: 10.18632/Oncotarget.5747 |
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| 2015 |
Zhang GN, Ashby CR, Zhang YK, Chen ZS, Guo H. The reversal of antineoplastic drug resistance in cancer cells by β-elemene. Chinese Journal of Cancer. 34: 45. PMID 26370907 DOI: 10.1186/S40880-015-0048-0 |
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Zhang YK, Zhang H, Zhang GN, Wang YJ, Kathawala RJ, Si R, Patel BA, Xu J, Chen ZS. Semi-synthetic ocotillol analogues as selective ABCB1-mediated drug resistance reversal agents. Oncotarget. PMID 26296969 DOI: 10.18632/Oncotarget.4493 |
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| 2015 |
Singha B, Gatla HR, Phyo S, Patel A, Chen ZS, Vancurova I. IKK inhibition increases bortezomib effectiveness in ovarian cancer. Oncotarget. 6: 26347-58. PMID 26267322 DOI: 10.18632/Oncotarget.4713 |
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Huang Y, Wang YJ, Wang Y, Yi S, Fan Z, Sun L, Lin D, Anreddy N, Zhu H, Schmidt M, Chen ZS, Zhang M. Exploring naturally occurring ivy nanoparticles as an alternative biomaterial. Acta Biomaterialia. PMID 26219859 DOI: 10.1016/J.Actbio.2015.07.035 |
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Dai C, Ma S, Wang F, Zhao H, Wu X, Huang Z, Chen Z, To K, Fu L. Lapatinib promotes the incidence of hepatotoxicity by increasing chemotherapeutic agent accumulation in hepatocytes. Oncotarget. PMID 26036634 DOI: 10.18632/ONCOTARGET.3921 |
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Kathawala RJ, Wang YJ, Shukla S, Zhang YK, Alqahtani S, Kaddoumi A, Ambudkar SV, Ashby CR, Chen ZS. ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) are not primary resistance factors for cabazitaxel. Chinese Journal of Cancer. 34: 115-20. PMID 25962593 DOI: 10.1186/S40880-015-0003-0 |
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Zhang Y, Zhang YK, Wang YJ, Vispute SG, Jain S, Chen Y, Li J, Youssef DT, Sayed KA, Chen ZS. Esters of the marine-derived triterpene sipholenol A reverse P-GP-mediated drug resistance. Marine Drugs. 13: 2267-86. PMID 25874923 DOI: 10.3390/Md13042267 |
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Zhang YK, Wang YJ, Gupta P, Chen ZS. Multidrug Resistance Proteins (MRPs) and Cancer Therapy. The Aaps Journal. 17: 802-12. PMID 25840885 DOI: 10.1208/S12248-015-9757-1 |
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Liu DL, Li YJ, Yang DH, Wang CR, Xu J, Yao N, Zhang XQ, Chen ZS, Ye WC, Zhang DM. Ganoderma lucidum derived ganoderenic acid B reverses ABCB1-mediated multidrug resistance in HepG2/ADM cells. International Journal of Oncology. 46: 2029-38. PMID 25779097 DOI: 10.3892/Ijo.2015.2925 |
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| 2015 |
Kathawala RJ, Gupta P, Ashby CR, Chen ZS. The modulation of ABC transporter-mediated multidrug resistance in cancer: a review of the past decade. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 18: 1-17. PMID 25554624 DOI: 10.1016/J.Drup.2014.11.002 |
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| 2015 |
Hasinoff BB, Wu X, Yadav AA, Patel D, Zhang H, Wang DS, Chen ZS, Yalowich JC. Cellular mechanisms of the cytotoxicity of the anticancer drug elesclomol and its complex with Cu(II). Biochemical Pharmacology. 93: 266-76. PMID 25550273 DOI: 10.1016/J.Bcp.2014.12.008 |
0.397 |
|
| 2015 |
Wei L, Lu J, Xu H, Patel A, Chen ZS, Chen G. Silver nanoparticles: synthesis, properties, and therapeutic applications. Drug Discovery Today. 20: 595-601. PMID 25543008 DOI: 10.1016/J.Drudis.2014.11.014 |
0.685 |
|
| 2015 |
Kathawala RJ, Wei L, Anreddy N, Chen K, Patel A, Alqahtani S, Zhang YK, Wang YJ, Sodani K, Kaddoumi A, Ashby CR, Chen ZS. The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study. Oncotarget. 6: 510-21. PMID 25402202 DOI: 10.18632/Oncotarget.2638 |
0.876 |
|
| 2015 |
Anreddy N, Kumar P, Patel A, Zhang Y, Wang Y, Kathawala R, Wurpel JD, Chen Z. Abstract A01: A-803467, a sodium channel blocker, reverses ABCG2-mediated MDR in vitro as well as in vivo Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Pms14-A01 |
0.85 |
|
| 2015 |
Anreddy N, Patel A, Zhang Y, Wang Y, Shukla S, Kathawala RJ, Kumar P, Gupta P, Ambudkar SV, Wurpel JN, Chen Z. Abstract 4432: A-803467, a tetrodotoxin-resistant sodium channel blocker, modulates ABCG2-mediated MDR in vitro and in vivo Cancer Research. 75: 4432-4432. DOI: 10.1158/1538-7445.Am2015-4432 |
0.847 |
|
| 2015 |
Wang Y, Anreddy N, Patel BA, Chufan EE, Singh S, Zhang G, Zhang Y, Barbuti AM, Ambudkar SV, Talele TT, Chen Z. Abstract 4422: TTT-28, a newly synthesized thiazole-valine peptide, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1 transporter Cancer Research. 75: 4422-4422. DOI: 10.1158/1538-7445.Am2015-4422 |
0.676 |
|
| 2015 |
Patel AS, Li T, Anreddy N, Zhao Y, Kathawala RJ, Wang Y, Ambudkar SV, Chen Z, Cheng C. Abstract 4419: Design, synthesis and biological evaluation of N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamide analog as a promising inhibitor of the multidrug resistance-linked ABCG2 transporter Cancer Research. 75: 4419-4419. DOI: 10.1158/1538-7445.Am2015-4419 |
0.692 |
|
| 2015 |
Dai C, Ma S, Chen Z, To K, Fu L. Abstract 2627: Lapatinib promotes promoted the incidence of hepatotoxicity by increasing chemotherapeutic agent accumulation in hepatocytes Cancer Research. 75: 2627-2627. DOI: 10.1158/1538-7445.Am2015-2627 |
0.462 |
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| 2014 |
Chen G, Chen R, Zou C, Yang D, Chen ZS. Fragmented polymer nanotubes from sonication-induced scission with a thermo-responsive gating system for anti-cancer drug delivery. Journal of Materials Chemistry. B. 2: 1327-1334. PMID 32261447 DOI: 10.1039/C3Tb21512A |
0.349 |
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| 2014 |
Anreddy N, Patel A, Sodani K, Kathawala RJ, Chen EP, Wurpel JN, Chen ZS. PD173074, a selective FGFR inhibitor, reverses MRP7 (ABCC10)-mediated MDR. Acta Pharmaceutica Sinica. B. 4: 202-207. PMID 26579384 DOI: 10.1016/J.Apsb.2014.02.003 |
0.843 |
|
| 2014 |
Wang J, Wang YJ, Chen ZS, Kwon CH. Synthesis and evaluation of sulfonylethyl-containing phosphotriesters of 3'-azido-3'-deoxythymidine as anticancer prodrugs. Bioorganic & Medicinal Chemistry. 22: 5747-56. PMID 25440502 DOI: 10.1016/J.Bmc.2014.09.046 |
0.349 |
|
| 2014 |
Wang YJ, Zhang YK, Kathawala RJ, Chen ZS. Repositioning of Tyrosine Kinase Inhibitors as Antagonists of ATP-Binding Cassette Transporters in Anticancer Drug Resistance. Cancers. 6: 1925-52. PMID 25268163 DOI: 10.3390/Cancers6041925 |
0.679 |
|
| 2014 |
Sui H, Cai GX, Pan SF, Deng WL, Wang YW, Chen ZS, Cai SJ, Zhu HR, Li Q. miR200c attenuates P-gp-mediated MDR and metastasis by targeting JNK2/c-Jun signaling pathway in colorectal cancer. Molecular Cancer Therapeutics. 13: 3137-51. PMID 25205654 DOI: 10.1158/1535-7163.MCT-14-0167 |
0.391 |
|
| 2014 |
Minami K, Kamijo Y, Nishizawa Y, Tabata S, Horikuchi F, Yamamoto M, Kawahara K, Shinsato Y, Tachiwada T, Chen ZS, Tsujikawa K, Nakagawa M, Seki N, Akiyama S, Arima K, et al. Expression of ABCB6 is related to resistance to 5-FU, SN-38 and vincristine. Anticancer Research. 34: 4767-73. PMID 25202056 |
0.55 |
|
| 2014 |
Anreddy N, Gupta P, Kathawala RJ, Patel A, Wurpel JN, Chen ZS. Tyrosine kinase inhibitors as reversal agents for ABC transporter mediated drug resistance. Molecules (Basel, Switzerland). 19: 13848-77. PMID 25191874 DOI: 10.3390/Molecules190913848 |
0.833 |
|
| 2014 |
Zhang H, Patel A, Ma SL, Li XJ, Zhang YK, Yang PQ, Kathawala RJ, Wang YJ, Anreddy N, Fu LW, Chen ZS. In vitro, in vivo and ex vivo characterization of ibrutinib: a potent inhibitor of the efflux function of the transporter MRP1. British Journal of Pharmacology. 171: 5845-57. PMID 25164592 DOI: 10.1111/Bph.12889 |
0.811 |
|
| 2014 |
Tang SJ, Chen LK, Wang F, Zhang YK, Huang ZC, To KK, Wang XK, Talele TT, Chen ZS, Chen WQ, Fu LW. CEP-33779 antagonizes ATP-binding cassette subfamily B member 1 mediated multidrug resistance by inhibiting its transport function. Biochemical Pharmacology. 91: 144-56. PMID 25058526 DOI: 10.1016/j.bcp.2014.07.008 |
0.655 |
|
| 2014 |
Xu S, Pei L, Wang C, Zhang YK, Li D, Yao H, Wu X, Chen ZS, Sun Y, Xu J. Novel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidates. Acs Medicinal Chemistry Letters. 5: 797-802. PMID 25050168 DOI: 10.1021/Ml500141F |
0.458 |
|
| 2014 |
Wang DS, Patel A, Shukla S, Zhang YK, Wang YJ, Kathawala RJ, Robey RW, Zhang L, Yang DH, Talele TT, Bates SE, Ambudkar SV, Xu RH, Chen ZS. Icotinib antagonizes ABCG2-mediated multidrug resistance, but not the pemetrexed resistance mediated by thymidylate synthase and ABCG2. Oncotarget. 5: 4529-42. PMID 24980828 DOI: 10.18632/Oncotarget.2102 |
0.843 |
|
| 2014 |
Huang XC, Xiao X, Zhang YK, Talele TT, Salim AA, Chen ZS, Capon RJ. Lamellarin O, a pyrrole alkaloid from an Australian marine sponge, Ianthella sp., reverses BCRP mediated drug resistance in cancer cells. Marine Drugs. 12: 3818-37. PMID 24979269 DOI: 10.3390/Md12073818 |
0.638 |
|
| 2014 |
Wang DS, Patel A, Sim HM, Zhang YK, Wang YJ, Kathawala RJ, Zhang H, Talele TT, Ambudkar SV, Xu RH, Chen ZS. ARRY-334543 reverses multidrug resistance by antagonizing the activity of ATP-binding cassette subfamily G member 2. Journal of Cellular Biochemistry. 115: 1381-91. PMID 24939447 DOI: 10.1002/Jcb.24787 |
0.841 |
|
| 2014 |
Wang YJ, Kathawala RJ, Zhang YK, Patel A, Kumar P, Shukla S, Fung KL, Ambudkar SV, Talele TT, Chen ZS. Motesanib (AMG706), a potent multikinase inhibitor, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1. Biochemical Pharmacology. 90: 367-78. PMID 24937702 DOI: 10.1016/J.Bcp.2014.06.006 |
0.863 |
|
| 2014 |
Zhang H, Zhang YK, Wang YJ, Kathawala RJ, Patel A, Zhu H, Sodani K, Talele TT, Ambudkar SV, Chen ZS, Fu LW. WHI-P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2-overexpressing cells. Cancer Science. 105: 1071-8. PMID 24903205 DOI: 10.1111/Cas.12462 |
0.873 |
|
| 2014 |
Singh S, Prasad NR, Chufan EE, Patel BA, Wang YJ, Chen ZS, Ambudkar SV, Talele TT. Design and synthesis of human ABCB1 (P-glycoprotein) inhibitors by peptide coupling of diverse chemical scaffolds on carboxyl and amino termini of (S)-valine-derived thiazole amino acid. Journal of Medicinal Chemistry. 57: 4058-72. PMID 24773054 DOI: 10.1021/Jm401966M |
0.453 |
|
| 2014 |
Zhang H, Wang YJ, Zhang YK, Wang DS, Kathawala RJ, Patel A, Talele TT, Chen ZS, Fu LW. AST1306, a potent EGFR inhibitor, antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance. Cancer Letters. 350: 61-8. PMID 24747122 DOI: 10.1016/J.Canlet.2014.04.008 |
0.806 |
|
| 2014 |
Zhang H, Kathawala RJ, Wang YJ, Zhang YK, Patel A, Shukla S, Robey RW, Talele TT, Ashby CR, Ambudkar SV, Bates SE, Fu LW, Chen ZS. Linsitinib (OSI-906) antagonizes ATP-binding cassette subfamily G member 2 and subfamily C member 10-mediated drug resistance. The International Journal of Biochemistry & Cell Biology. 51: 111-9. PMID 24726739 DOI: 10.1016/J.Biocel.2014.03.026 |
0.835 |
|
| 2014 |
Liu DL, Li YJ, Yao N, Xu J, Chen ZS, Yiu A, Zhang CX, Ye WC, Zhang DM. Acerinol, a cyclolanstane triterpenoid from Cimicifuga acerina, reverses ABCB1-mediated multidrug resistance in HepG2/ADM and MCF-7/ADR cells. European Journal of Pharmacology. 733: 34-44. PMID 24704556 DOI: 10.1016/J.Ejphar.2014.03.043 |
0.71 |
|
| 2014 |
Kathawala RJ, Chen JJ, Zhang YK, Wang YJ, Patel A, Wang DS, Talele TT, Ashby CR, Chen ZS. Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance. International Journal of Oncology. 44: 1634-42. PMID 24626598 DOI: 10.3892/Ijo.2014.2341 |
0.833 |
|
| 2014 |
Sodani K, Patel A, Anreddy N, Singh S, Yang DH, Kathawala RJ, Kumar P, Talele TT, Chen ZS. Telatinib reverses chemotherapeutic multidrug resistance mediated by ABCG2 efflux transporter in vitro and in vivo. Biochemical Pharmacology. 89: 52-61. PMID 24565910 DOI: 10.1016/J.Bcp.2014.02.012 |
0.889 |
|
| 2014 |
Sun YL, Kumar P, Sodani K, Patel A, Pan Y, Baer MR, Chen ZS, Jiang WQ. Ponatinib enhances anticancer drug sensitivity in MRP7-overexpressing cells. Oncology Reports. 31: 1605-12. PMID 24481648 DOI: 10.3892/Or.2014.3002 |
0.898 |
|
| 2014 |
Kathawala RJ, Sodani K, Chen K, Patel A, Abuznait AH, Anreddy N, Sun YL, Kaddoumi A, Ashby CR, Chen ZS. Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated paclitaxel resistance: a preclinical study. Molecular Cancer Therapeutics. 13: 714-23. PMID 24431074 DOI: 10.1158/1535-7163.Mct-13-0743 |
0.879 |
|
| 2014 |
Yang D, Kathawala RJ, Chufan EE, Patel A, Ambudkar SV, Chen ZS, Chen X. Tivozanib reverses multidrug resistance mediated by ABCB1 (P-glycoprotein) and ABCG2 (BCRP). Future Oncology (London, England). 10: 1827-41. PMID 24295377 DOI: 10.2217/Fon.13.253 |
0.809 |
|
| 2014 |
Guo HQ, Zhang GN, Wang YJ, Zhang YK, Sodani K, Talele TT, Ashby CR, Chen ZS. β-Elemene, a compound derived from Rhizoma zedoariae, reverses multidrug resistance mediated by the ABCB1 transporter. Oncology Reports. 31: 858-66. PMID 24284783 DOI: 10.3892/Or.2013.2870 |
0.783 |
|
| 2014 |
Kathawala RJ, Wang YJ, Ashby CR, Chen ZS. Recent advances regarding the role of ABC subfamily C member 10 (ABCC10) in the efflux of antitumor drugs. Chinese Journal of Cancer. 33: 223-30. PMID 24103790 DOI: 10.5732/Cjc.013.10122 |
0.664 |
|
| 2014 |
Yan XJ, Gong LH, Zheng FY, Cheng KJ, Chen ZS, Shi Z. Triterpenoids as reversal agents for anticancer drug resistance treatment. Drug Discovery Today. 19: 482-8. PMID 23954181 DOI: 10.1016/J.Drudis.2013.07.018 |
0.631 |
|
| 2014 |
Sodani K, Tiwari AK, Dai C, Abuznait AH, Patel A, Xiao Z, Ashby CR, Kaddoumi A, Fu L, Chen Z. Sildenafil Enhances the Anticancer Activity of Paclitaxel in an ABCB1-Mediated Multidrug Resistance Xenograft Mouse Model Journal of Cancer Research Updates. 3: 169-173. DOI: 10.6000/1929-2279.2014.03.03.7 |
0.876 |
|
| 2014 |
Zhi Shi ZS, Rizwani G, Wang D, Ahmed M, Hassan A, Lai Z, Zahid A, Mansoor N, Sharif H, Chen Z. Anticancer Activity of Five Traditionally Used Medicinal Plants’ Extracts Journal of Cancer Research Updates. 3: 103-107. DOI: 10.6000/1929-2279.2014.03.02.4 |
0.318 |
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| 2014 |
Yao N, Liu D, Li Y, Chen Z, Shi Z, Chen W, Yao Z, Zhang D, Ye W. B5H7, a Morpholine Derivative of 23-Hydroxybetulinic Acid, Reverses Doxorubicin Resistance in HepG2/ADM Journal of Cancer Research Updates. 3: 59-66. DOI: 10.6000/1929-2279.2014.03.01.6 |
0.625 |
|
| 2014 |
Kathawala R, Sodani K, Chen K, Patel A, Abuznait A, Anreddy N, Sun Y, Kaddoumi A, Ashby CR, Chen Z. Abstract 1964: Masitinib antagonizes ATP-binding cassette subfamily c member 10-mediated paclitaxel resistance: a preclinical study Cancer Research. 74: 1964-1964. DOI: 10.1158/1538-7445.Am2014-1964 |
0.885 |
|
| 2013 |
Chen JJ, Patel A, Sodani K, Xiao ZJ, Tiwari AK, Zhang DM, Li YJ, Yang DH, Ye WC, Chen SD, Chen ZS. bba, a synthetic derivative of 23-hydroxybutulinic acid, reverses multidrug resistance by inhibiting the efflux activity of MRP7 (ABCC10). Plos One. 8: e74573. PMID 24069321 DOI: 10.1371/Journal.Pone.0074573 |
0.874 |
|
| 2013 |
Tiwari AK, Chen ZS. Repurposing phosphodiesterase-5 inhibitors as chemoadjuvants. Frontiers in Pharmacology. 4: 82. PMID 23805103 DOI: 10.3389/Fphar.2013.00082 |
0.409 |
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| 2013 |
Patel A, Tiwari AK, Chufan EE, Sodani K, Anreddy N, Singh S, Ambudkar SV, Stephani R, Chen ZS. PD173074, a selective FGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells. Cancer Chemotherapy and Pharmacology. 72: 189-99. PMID 23673445 DOI: 10.1007/S00280-013-2184-Z |
0.863 |
|
| 2013 |
Zhao XQ, Dai CL, Ohnuma S, Liang YJ, Deng W, Chen JJ, Zeng MS, Ambudkar SV, Chen ZS, Fu LW. Tandutinib (MLN518/CT53518) targeted to stem-like cells by inhibiting the function of ATP-binding cassette subfamily G member 2. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 49: 441-50. PMID 23619284 DOI: 10.1016/j.ejps.2013.04.015 |
0.513 |
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| 2013 |
Deng W, Dai CL, Chen JJ, Kathawala RJ, Sun YL, Chen HF, Fu LW, Chen ZS. Tandutinib (MLN518) reverses multidrug resistance by inhibiting the efflux activity of the multidrug resistance protein 7 (ABCC10). Oncology Reports. 29: 2479-85. PMID 23525656 DOI: 10.3892/or.2013.2362 |
0.673 |
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| 2013 |
Zhang DM, Li YJ, Shu C, Ruan ZX, Chen WM, Yiu A, Peng YH, Wang J, Lan P, Yao Z, Fung KP, Fu LW, Chen ZS, Ye WC. Bipiperidinyl derivatives of 23-hydroxybetulinic acid reverse resistance of HepG2/ADM and MCF-7/ADR cells. Anti-Cancer Drugs. 24: 441-54. PMID 23466650 DOI: 10.1097/CAD.0b013e32835fcc77 |
0.542 |
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| 2013 |
Huang XC, Sun YL, Salim AA, Chen ZS, Capon RJ. Parguerenes: Marine red alga bromoditerpenes as inhibitors of P-glycoprotein (ABCB1) in multidrug resistant human cancer cells. Biochemical Pharmacology. 85: 1257-68. PMID 23415901 DOI: 10.1016/J.Bcp.2013.02.005 |
0.609 |
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| 2013 |
Sun YL, Chen JJ, Kumar P, Chen K, Sodani K, Patel A, Chen YL, Chen SD, Jiang WQ, Chen ZS. Reversal of MRP7 (ABCC10)-mediated multidrug resistance by tariquidar. Plos One. 8: e55576. PMID 23393594 DOI: 10.1371/Journal.Pone.0055576 |
0.883 |
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| 2013 |
He D, Zhao XQ, Chen XG, Fang Y, Singh S, Talele TT, Qiu HJ, Liang YJ, Wang XK, Zhang GQ, Chen ZS, Fu LW. BIRB796, the inhibitor of p38 mitogen-activated protein kinase, enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cells. Plos One. 8: e54181. PMID 23349819 DOI: 10.1371/journal.pone.0054181 |
0.557 |
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| 2013 |
Natarajan K, Bhullar J, Shukla S, Burcu M, Chen ZS, Ambudkar SV, Baer MR. The Pim kinase inhibitor SGI-1776 decreases cell surface expression of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and drug transport by Pim-1-dependent and -independent mechanisms. Biochemical Pharmacology. 85: 514-24. PMID 23261525 DOI: 10.1016/J.Bcp.2012.12.006 |
0.647 |
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| 2013 |
Tiwari AK, Sodani K, Dai CL, Abuznait AH, Singh S, Xiao ZJ, Patel A, Talele TT, Fu L, Kaddoumi A, Gallo JM, Chen ZS. Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models. Cancer Letters. 328: 307-17. PMID 23063650 DOI: 10.1016/J.Canlet.2012.10.001 |
0.864 |
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| 2013 |
Liu KJ, He JH, Su XD, Sim HM, Xie JD, Chen XG, Wang F, Liang YJ, Singh S, Sodani K, Talele TT, Ambudkar SV, Chen ZS, Wu HY, Fu LW. Saracatinib (AZD0530) is a potent modulator of ABCB1-mediated multidrug resistance in vitro and in vivo. International Journal of Cancer. Journal International Du Cancer. 132: 224-35. PMID 22623106 DOI: 10.1002/Ijc.27649 |
0.843 |
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| 2013 |
Vispute SG, Chen J, Sun Y, Sodani KS, Singh S, Pan Y, Talele T, Ashby CR, Chen Z. Vemurafenib (PLX4032, Zelboraf®), a BRAF Inhibitor, Modulates ABCB1-, ABCG2-, and ABCC10-Mediated Multidrug Resistance Journal of Cancer Research Updates. 2: 306-317. DOI: 10.6000/1929-2279.2013.02.04.9 |
0.857 |
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| 2013 |
Deng W, Hu B, Dai C, Wang Y, Chen H, Zito SW, Fu L, Chen Z. Anticancer Activity of Oldenlandia Diffusa & Viola Philippica Car Journal of Cancer Research Updates. 2: 87-94. DOI: 10.6000/1929-2279.2013.02.02.1 |
0.504 |
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| 2013 |
Sodani K, Tiwari AK, Dai C, Abuznait AH, Xiao Z, Kaddouni A, Chen Z. Abstract 986: Sildenafil potentiates the anticancer activity of paclitaxel in ABCB1-mediated multidrug resistance xenograft model. Cancer Research. 73: 986-986. DOI: 10.1158/1538-7445.Am2013-986 |
0.849 |
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| 2013 |
Patel AS, Tiwari A, Chufan E, Singh S, Sodani K, Anreddy N, Talele T, Ambudkar S, Stephani R, Chen Z. Abstract 980: PD173074, a selective FGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells. Cancer Research. 73: 980-980. DOI: 10.1158/1538-7445.Am2013-980 |
0.814 |
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| 2013 |
Wang D, Patel A, Kumar P, Xu R, Chen Z. Abstract B112: ARRY-334543 reverses multidrug resistance by antagonizing the activity of ATP-binding cassette subfamily G member 2. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-B112 |
0.844 |
|
| 2012 |
Kumar P, Zhang DM, Degenhardt K, Chen ZS. Autophagy and transporter-based multi-drug resistance. Cells. 1: 558-75. PMID 24710490 DOI: 10.3390/Cells1030558 |
0.509 |
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| 2012 |
Abraham I, El Sayed K, Chen ZS, Guo H. Current status on marine products with reversal effect on cancer multidrug resistance. Marine Drugs. 10: 2312-21. PMID 23170086 DOI: 10.3390/Md10102312 |
0.811 |
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| 2012 |
Li T, Yang Y, Cheng C, Tiwari AK, Sodani K, Zhao Y, Abraham I, Chen ZS. Design, synthesis and biological evaluation of N-arylphenyl-2,2-dichloroacetamide analogues as anti-cancer agents. Bioorganic & Medicinal Chemistry Letters. 22: 7268-71. PMID 23067553 DOI: 10.1016/J.Bmcl.2012.07.057 |
0.792 |
|
| 2012 |
Zhang DM, Shu C, Chen JJ, Sodani K, Wang J, Bhatnagar J, Lan P, Ruan ZX, Xiao ZJ, Ambudkar SV, Chen WM, Chen ZS, Ye WC. BBA, a derivative of 23-hydroxybetulinic acid, potently reverses ABCB1-mediated drug resistance in vitro and in vivo. Molecular Pharmaceutics. 9: 3147-59. PMID 23046348 DOI: 10.1021/Mp300249S |
0.841 |
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| 2012 |
Shi Z, Yang WM, Chen LP, Yang DH, Zhou Q, Zhu J, Chen JJ, Huang RC, Chen ZS, Huang RP. Enhanced chemosensitization in multidrug-resistant human breast cancer cells by inhibition of IL-6 and IL-8 production. Breast Cancer Research and Treatment. 135: 737-47. PMID 22923236 DOI: 10.1007/S10549-012-2196-0 |
0.484 |
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| 2012 |
Sen R, Natarajan K, Bhullar J, Shukla S, Fang HB, Cai L, Chen ZS, Ambudkar SV, Baer MR. The novel BCR-ABL and FLT3 inhibitor ponatinib is a potent inhibitor of the MDR-associated ATP-binding cassette transporter ABCG2. Molecular Cancer Therapeutics. 11: 2033-44. PMID 22778153 DOI: 10.1158/1535-7163.Mct-12-0302 |
0.608 |
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| 2012 |
Kuang YH, Patel JP, Sodani K, Wu CP, Liao LQ, Patel A, Tiwari AK, Dai CL, Chen X, Fu LW, Ambudkar SV, Korlipara VL, Chen ZS. OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance. Biochemical Pharmacology. 84: 766-74. PMID 22750060 DOI: 10.1016/J.Bcp.2012.06.019 |
0.872 |
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| 2012 |
Cheng C, Liu ZG, Zhang H, Xie JD, Chen XG, Zhao XQ, Wang F, Liang YJ, Chen LK, Singh S, Chen JJ, Talele TT, Chen ZS, Zhong FT, Fu LW. Enhancing chemosensitivity in ABCB1- and ABCG2-overexpressing cells and cancer stem-like cells by an Aurora kinase inhibitor CCT129202. Molecular Pharmaceutics. 9: 1971-82. PMID 22632055 DOI: 10.1021/mp2006714 |
0.543 |
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| 2012 |
Sun YL, Kathawala RJ, Singh S, Zheng K, Talele TT, Jiang WQ, Chen ZS. Zafirlukast antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance. Anti-Cancer Drugs. 23: 865-73. PMID 22614107 DOI: 10.1097/CAD.0b013e328354a196 |
0.611 |
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| 2012 |
Chen JJ, Sun YL, Tiwari AK, Xiao ZJ, Sodani K, Yang DH, Vispute SG, Jiang WQ, Chen SD, Chen ZS. PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter. Cancer Science. 103: 1531-7. PMID 22578167 DOI: 10.1111/J.1349-7006.2012.02328.X |
0.839 |
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| 2012 |
Zhao XQ, Xie JD, Chen XG, Sim HM, Zhang X, Liang YJ, Singh S, Talele TT, Sun Y, Ambudkar SV, Chen ZS, Fu LW. Neratinib reverses ATP-binding cassette B1-mediated chemotherapeutic drug resistance in vitro, in vivo, and ex vivo. Molecular Pharmacology. 82: 47-58. PMID 22491935 DOI: 10.1124/mol.111.076299 |
0.564 |
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| 2012 |
Sodani K, Tiwari AK, Singh S, Patel A, Xiao ZJ, Chen JJ, Sun YL, Talele TT, Chen ZS. GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance. Biochemical Pharmacology. 83: 1613-22. PMID 22414725 DOI: 10.1016/J.Bcp.2012.02.028 |
0.887 |
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| 2012 |
Shukla S, Chen ZS, Ambudkar SV. Tyrosine kinase inhibitors as modulators of ABC transporter-mediated drug resistance. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 15: 70-80. PMID 22325423 DOI: 10.1016/J.Drup.2012.01.005 |
0.614 |
|
| 2012 |
Sun YL, Patel A, Kumar P, Chen ZS. Role of ABC transporters in cancer chemotherapy. Chinese Journal of Cancer. 31: 51-7. PMID 22257384 DOI: 10.5732/Cjc.011.10466 |
0.831 |
|
| 2012 |
Sodani K, Patel A, Kathawala RJ, Chen ZS. Multidrug resistance associated proteins in multidrug resistance. Chinese Journal of Cancer. 31: 58-72. PMID 22098952 DOI: 10.5732/Cjc.011.10329 |
0.871 |
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| 2012 |
Peng XX, Tiwari AK, Wu HC, Chen ZS. Overexpression of P-glycoprotein induces acquired resistance to imatinib in chronic myelogenous leukemia cells. Chinese Journal of Cancer. 31: 110-8. PMID 22098951 DOI: 10.5732/Cjc.011.10327 |
0.827 |
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| 2012 |
Sodani KS, Tiwari AK, Singh S, Patel A, Xiao Z, Chen J, Sun Y, Talele TT, Chen Z. Abstract 777: GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance Cancer Research. 72: 777-777. DOI: 10.1158/1538-7445.Am2012-777 |
0.882 |
|
| 2012 |
Deng W, Dai C, Zhao X, Ohnuma S, Liang Y, Xiao Z, Zeng M, Ambudkar SV, Fu L, Chen Z. Abstract 5614: Tandutinib (MLN518/CT53518) targeted to stem-like cells by inhibiting the function of ATP-binding cassette subfamily G member 2 Cancer Research. 72: 5614-5614. DOI: 10.1158/1538-7445.Am2012-5614 |
0.344 |
|
| 2011 |
Peng XX, Shi Z, Tiwari AK, Damaraju VL, Fu L, Cass CE, Ashby CR, Kruh GD, Chen ZS. Up-regulation of P-glycoprotein confers acquired resistance to 6-mercaptopurine in human chronic myeloid leukemia cells. Oncology Letters. 2: 549-556. PMID 22866119 DOI: 10.3892/ol.2011.288 |
0.795 |
|
| 2011 |
Patel JP, Kuang YH, Chen ZS, Korlipara VL. Inhibition of c-Kit, VEGFR-2 (KDR), and ABCG2 by analogues of OSI-930 Bioorganic and Medicinal Chemistry Letters. 21: 6495-6499. PMID 21920748 DOI: 10.1016/J.Bmcl.2011.08.070 |
0.373 |
|
| 2011 |
Yan YY, Zheng LS, Zhang X, Chen LK, Singh S, Wang F, Zhang JY, Liang YJ, Dai CL, Gu LQ, Zeng MS, Talele TT, Chen ZS, Fu LW. Blockade of Her2/neu binding to Hsp90 by emodin azide methyl anthraquinone derivative induces proteasomal degradation of Her2/neu. Molecular Pharmaceutics. 8: 1687-97. PMID 21812426 DOI: 10.1021/mp2000499 |
0.336 |
|
| 2011 |
Chen ZS, Tiwari AK. Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases. The Febs Journal. 278: 3226-45. PMID 21740521 DOI: 10.1111/J.1742-4658.2011.08235.X |
0.583 |
|
| 2011 |
Shi Z, Tiwari AK, Patel AS, Fu LW, Chen ZS. Roles of sildenafil in enhancing drug sensitivity in cancer. Cancer Research. 71: 3735-8. PMID 21610107 DOI: 10.1158/0008-5472.CAN-11-0375 |
0.828 |
|
| 2011 |
Hopper-Borge EA, Churchill T, Paulose C, Nicolas E, Jacobs JD, Ngo O, Kuang Y, Grinberg A, Westphal H, Chen ZS, Klein-Szanto AJ, Belinsky MG, Kruh GD. Contribution of Abcc10 (Mrp7) to in vivo paclitaxel resistance as assessed in Abcc10(-/-) mice. Cancer Research. 71: 3649-57. PMID 21576088 DOI: 10.1158/0008-5472.Can-10-3623 |
0.563 |
|
| 2011 |
Ding PR, Tiwari AK, Ohnuma S, Lee JW, An X, Dai CL, Lu QS, Singh S, Yang DH, Talele TT, Ambudkar SV, Chen ZS. The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter. Plos One. 6: e19329. PMID 21552528 DOI: 10.1371/journal.pone.0019329 |
0.644 |
|
| 2011 |
Shi Z, Tiwari AK, Shukla S, Robey RW, Singh S, Kim IW, Bates SE, Peng X, Abraham I, Ambudkar SV, Talele TT, Fu LW, Chen ZS. Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance. Cancer Research. 71: 3029-41. PMID 21402712 DOI: 10.1158/0008-5472.Can-10-3820 |
0.868 |
|
| 2011 |
Tiwari AK, Sodani K, Dai CL, Ashby CR, Chen ZS. Revisiting the ABCs of multidrug resistance in cancer chemotherapy. Current Pharmaceutical Biotechnology. 12: 570-94. PMID 21118094 DOI: 10.2174/138920111795164048 |
0.829 |
|
| 2011 |
Patel JP, Kuang Y, Sodani K, Wu C, Liao L, Tiwari AK, Dai C, Chen X, Fu L, Ambudkar SV, Korlipara VL, Chen Z. Abstract 1740: Analogs of OSI-930 as potent ABCG2-mediated multidrug resistance reversal agents Cancer Research. 71: 1740-1740. DOI: 10.1158/1538-7445.Am2011-1740 |
0.838 |
|
| 2011 |
Tiwari AK, Shi Z, Shukla S, Robey RW, Singh S, Kim I, Bates SE, Peng X, Abraham I, Ambudkar SV, Talele TT, Fu L, Chen Z. Abstract 1739: Reversal of ABCB1- and ABCG2-mediated drug resistance by sildenafil Cancer Research. 71: 1739-1739. DOI: 10.1158/1538-7445.Am2011-1739 |
0.849 |
|
| 2010 |
Mi YJ, Liang YJ, Huang HB, Zhao HY, Wu CP, Wang F, Tao LY, Zhang CZ, Dai CL, Tiwari AK, Ma XX, To KK, Ambudkar SV, Chen ZS, Fu LW. Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters. Cancer Research. 70: 7981-91. PMID 20876799 DOI: 10.1158/0008-5472.CAN-10-0111 |
0.635 |
|
| 2010 |
Abraham I, Jain S, Wu CP, Khanfar MA, Kuang Y, Dai CL, Shi Z, Chen X, Fu L, Ambudkar SV, El Sayed K, Chen ZS. Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells. Biochemical Pharmacology. 80: 1497-506. PMID 20696137 DOI: 10.1016/J.Bcp.2010.08.001 |
0.761 |
|
| 2010 |
Tiwari AK, An X, Chen ZS. The role of stem cell markers in multidrug resistance mediated by ABC transporters. Leukemia Research. 34: 696-7. PMID 20061021 DOI: 10.1016/J.Leukres.2009.12.007 |
0.528 |
|
| 2010 |
Kuang YH, Shen T, Chen X, Sodani K, Hopper-Borge E, Tiwari AK, Lee JW, Fu LW, Chen ZS. Lapatinib and erlotinib are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistance. Biochemical Pharmacology. 79: 154-61. PMID 19720054 DOI: 10.1016/J.Bcp.2009.08.021 |
0.85 |
|
| 2010 |
Chun-ling D, Liang Y, Wang Y, Tiwari AK, Yan Y, Wang F, Chen Z, Tong X, Fu L. Abstract 1533: Sunitinib reverses ABCG2/BCRP-mediated multidrug resistance by inhibiting its efflux activity Cancer Research. 70: 1533-1533. DOI: 10.1158/1538-7445.Am10-1533 |
0.651 |
|
| 2010 |
Tiwari AK, Sodani K, Wang S, Kuang Y, Deng W, Chen X, Chen K, Ashby CR, Chen Z. Abstract 1531: BCR-Abl tyrosine kinase inhibitor Nilotinib (Tasigna®) reverses ABCB1/Pgp- and ABCG2/BCRP-mediated multidrug resistance Cancer Research. 70: 1531-1531. DOI: 10.1158/1538-7445.Am10-1531 |
0.861 |
|
| 2010 |
Sodani K, Kuang Y, Shen T, Vispute S, Tiwari AK, Lei Y, Lee J, Chen X, Ashby CR, Chen Z. Abstract 1519: Tyrosine kinase inhibitors are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistance Cancer Research. 70: 1519-1519. DOI: 10.1158/1538-7445.Am10-1519 |
0.855 |
|
| 2010 |
AOKI S, YOSHIOKA Y, MIYAMOTO Y, HIGUCHI K, SETIAWAN A, MURAKAMI N, CHEN Z, SUMIZAWA T, AKIYAMA S, KOBAYASHI M. ChemInform Abstract: Agosterol A, a Novel Polyhydroxylated Sterol Acetate Reversing Multidrug Resistance from a Marine Sponge of Spongia sp. Cheminform. 29: no-no. DOI: 10.1002/CHIN.199846216 |
0.351 |
|
| 2009 |
Shen T, Kuang YH, Ashby CR, Lei Y, Chen A, Zhou Y, Chen X, Tiwari AK, Hopper-Borge E, Ouyang J, Chen ZS. Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 (ABCC10). Plos One. 4: e7520. PMID 19841739 DOI: 10.1371/Journal.Pone.0007520 |
0.707 |
|
| 2009 |
Jain S, Abraham I, Carvalho P, Kuang YH, Shaala LA, Youssef DT, Avery MA, Chen ZS, El Sayed KA. Sipholane triterpenoids: chemistry, reversal of ABCB1/P-glycoprotein-mediated multidrug resistance, and pharmacophore modeling. Journal of Natural Products. 72: 1291-8. PMID 19534474 DOI: 10.1021/Np900091Y |
0.713 |
|
| 2009 |
Tiwari AK, Sodani K, Wang SR, Kuang YH, Ashby CR, Chen X, Chen ZS. Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters. Biochemical Pharmacology. 78: 153-61. PMID 19427995 DOI: 10.1016/J.Bcp.2009.04.002 |
0.863 |
|
| 2009 |
Dai CL, Liang YJ, Chen LM, Zhang X, Deng WJ, Su XD, Shi Z, Wu CP, Ashby CR, Akiyama S, Ambudkar SV, Chen ZS, Fu LW. Sensitization of ABCB1 overexpressing cells to chemotherapeutic agents by FG020326 via binding to ABCB1 and inhibiting its function. Biochemical Pharmacology. 78: 355-64. PMID 19410561 DOI: 10.1016/j.bcp.2009.04.023 |
0.595 |
|
| 2009 |
Guo Y, Köck K, Ritter CA, Chen ZS, Grube M, Jedlitschky G, Illmer T, Ayres M, Beck JF, Siegmund W, Ehninger G, Gandhi V, Kroemer HK, Kruh GD, Schaich M. Expression of ABCC-type nucleotide exporters in blasts of adult acute myeloid leukemia: relation to long-term survival. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 1762-9. PMID 19240178 DOI: 10.1158/1078-0432.CCR-08-0442 |
0.373 |
|
| 2009 |
Dai CL, Liang YJ, Wang YS, Tiwari AK, Yan YY, Wang F, Chen ZS, Tong XZ, Fu LW. Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2. Cancer Letters. 279: 74-83. PMID 19232821 DOI: 10.1016/j.canlet.2009.01.027 |
0.61 |
|
| 2009 |
Zhou Y, Hopper-Borge E, Shen T, Huang XC, Shi Z, Kuang YH, Furukawa T, Akiyama S, Peng XX, Ashby CR, Chen X, Kruh GD, Chen ZS. Cepharanthine is a potent reversal agent for MRP7(ABCC10)-mediated multidrug resistance. Biochemical Pharmacology. 77: 993-1001. PMID 19150344 DOI: 10.1016/J.Bcp.2008.12.005 |
0.861 |
|
| 2009 |
Shi Z, Parmar S, Peng XX, Shen T, Robey RW, Bates SE, Fu LW, Shao Y, Chen YM, Zang F, Chen ZS. The epidermal growth factor tyrosine kinase inhibitor AG1478 and erlotinib reverse ABCG2-mediated drug resistance. Oncology Reports. 21: 483-9. PMID 19148526 |
0.84 |
|
| 2009 |
Hopper-Borge E, Xu X, Shen T, Shi Z, Chen ZS, Kruh GD. Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B. Cancer Research. 69: 178-84. PMID 19118001 DOI: 10.1158/0008-5472.Can-08-1420 |
0.618 |
|
| 2009 |
Kuang YH, Chen X, Su J, Wu LS, Liao LQ, Li D, Chen ZS, Kanekura T. RNA interference targeting the CD147 induces apoptosis of multi-drug resistant cancer cells related to XIAP depletion. Cancer Letters. 276: 189-95. PMID 19097686 DOI: 10.1016/J.Canlet.2008.11.010 |
0.418 |
|
| 2009 |
Shi Z, Tiwari AK, Shukla S, Robey RW, Kim IW, Parmar S, Bates SE, Si QS, Goldblatt CS, Abraham I, Fu LW, Ambudkar SV, Chen ZS. Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochemical Pharmacology. 77: 781-93. PMID 19059384 DOI: 10.1016/J.Bcp.2008.11.007 |
0.739 |
|
| 2009 |
Shen T, Kuang Y, Ashby CR, Lei Y, Chen A, Zhou Y, Chen X, Tiwari AK, Hopper-Borge E, Ouyang J, Chen Z. Correction: Imatinib and Nilotinib Reverse Multidrug Resistance in Cancer Cells by Inhibiting the Efflux Activity of the MRP7 (ABCC10) Plos One. 4. DOI: 10.1371/annotation/e57b4610-9029-48db-9d57-5cc0fa35b8ac |
0.524 |
|
| 2008 |
Dai CL, Tiwari AK, Wu CP, Su XD, Wang SR, Liu DG, Ashby CR, Huang Y, Robey RW, Liang YJ, Chen LM, Shi CJ, Ambudkar SV, Chen ZS, Fu LW. Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2. Cancer Research. 68: 7905-14. PMID 18829547 DOI: 10.1158/0008-5472.CAN-08-0499 |
0.582 |
|
| 2008 |
Kuang YH, Chen X, Su J, Wu LS, Li J, Chang J, Qiu Y, Chen ZS, Kanekura T. Proteome analysis of multidrug resistance of human oral squamous carcinoma cells using CD147 silencing. Journal of Proteome Research. 7: 4784-91. PMID 18816083 DOI: 10.1021/Pr800355B |
0.436 |
|
| 2008 |
Peng XX, Shi Z, Damaraju VL, Huang XC, Kruh GD, Wu HC, Zhou Y, Tiwari A, Fu L, Cass CE, Chen ZS. Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine. Leukemia Research. 32: 799-809. PMID 17996297 DOI: 10.1016/j.leukres.2007.09.015 |
0.831 |
|
| 2007 |
Shi Z, Peng XX, Kim IW, Shukla S, Si QS, Robey RW, Bates SE, Shen T, Ashby CR, Fu LW, Ambudkar SV, Chen ZS. Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance. Cancer Research. 67: 11012-20. PMID 18006847 DOI: 10.1158/0008-5472.CAN-07-2686 |
0.868 |
|
| 2007 |
Wang L, Sun J, Li YQ, Chen ZS, Akiyama S, Xian LJ. Reversal effect of BM-cyclin 1 on multidrug resistance in C-A120 cells. Anti-Cancer Drugs. 18: 1015-21. PMID 17704651 DOI: 10.1097/Cad.0B013E328223F14D |
0.532 |
|
| 2007 |
Tachiwada T, Chen ZS, Che XF, Matsumoto M, Haraguchi M, Gotanda T, Sumizawa T, Furukawa T, Nishiyama K, Seki N, Yamamoto M, Nakagawa M, Akiyama S. Isolation and characterization of arsenite-resistant human epidermoid carcinoma KB cells. Oncology Reports. 18: 721-7. PMID 17671726 DOI: 10.3892/Or.18.3.721 |
0.605 |
|
| 2007 |
Shi Z, Jain S, Kim IW, Peng XX, Abraham I, Youssef DT, Fu LW, El Sayed K, Ambudkar SV, Chen ZS. Sipholenol A, a marine-derived sipholane triterpene, potently reverses P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells. Cancer Science. 98: 1373-80. PMID 17640301 DOI: 10.1111/J.1349-7006.2007.00554.X |
0.858 |
|
| 2007 |
Jain S, Laphookhieo S, Shi Z, Fu LW, Akiyama S, Chen ZS, Youssef DT, van Soest RW, El Sayed KA. Reversal of P-glycoprotein-mediated multidrug resistance by sipholane triterpenoids. Journal of Natural Products. 70: 928-31. PMID 17488128 DOI: 10.1021/Np0605889 |
0.409 |
|
| 2007 |
Shi Z, Liang YJ, Chen ZS, Wang XH, Ding Y, Chen LM, Fu LW. Overexpression of Survivin and XIAP in MDR cancer cells unrelated to P-glycoprotein. Oncology Reports. 17: 969-76. PMID 17342344 |
0.447 |
|
| 2007 |
Kruh GD, Guo Y, Hopper-Borge E, Belinsky MG, Chen ZS. ABCC10, ABCC11, and ABCC12. PflüGers Archiv : European Journal of Physiology. 453: 675-84. PMID 16868766 DOI: 10.1007/S00424-006-0114-1 |
0.55 |
|
| 2006 |
Shi Z, Liang YJ, Chen ZS, Wang XW, Wang XH, Ding Y, Chen LM, Yang XP, Fu LW. Reversal of MDR1/P-glycoprotein-mediated multidrug resistance by vector-based RNA interference in vitro and in vivo. Cancer Biology & Therapy. 5: 39-47. PMID 16319528 |
0.515 |
|
| 2005 |
Belinsky MG, Dawson PA, Shchaveleva I, Bain LJ, Wang R, Ling V, Chen ZS, Grinberg A, Westphal H, Klein-Szanto A, Lerro A, Kruh GD. Analysis of the in vivo functions of Mrp3. Molecular Pharmacology. 68: 160-8. PMID 15814571 DOI: 10.1124/Mol.104.010587 |
0.404 |
|
| 2005 |
Chen ZS, Guo Y, Belinsky MG, Kotova E, Kruh GD. Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). Molecular Pharmacology. 67: 545-57. PMID 15537867 DOI: 10.1124/Mol.104.007138 |
0.524 |
|
| 2004 |
Hopper-Borge E, Chen ZS, Shchaveleva I, Belinsky MG, Kruh GD. Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel. Cancer Research. 64: 4927-30. PMID 15256465 DOI: 10.1158/0008-5472.Can-03-3111 |
0.602 |
|
| 2003 |
Chen ZS, Robey RW, Belinsky MG, Shchaveleva I, Ren XQ, Sugimoto Y, Ross DD, Bates SE, Kruh GD. Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport. Cancer Research. 63: 4048-54. PMID 12874005 |
0.466 |
|
| 2003 |
Guo Y, Kotova E, Chen ZS, Lee K, Hopper-Borge E, Belinsky MG, Kruh GD. MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine. The Journal of Biological Chemistry. 278: 29509-14. PMID 12764137 DOI: 10.1074/Jbc.M304059200 |
0.63 |
|
| 2003 |
Chen ZS, Hopper-Borge E, Belinsky MG, Shchaveleva I, Kotova E, Kruh GD. Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). Molecular Pharmacology. 63: 351-8. PMID 12527806 DOI: 10.1124/Mol.63.2.351 |
0.511 |
|
| 2002 |
Belinsky MG, Chen ZS, Shchaveleva I, Zeng H, Kruh GD. Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Research. 62: 6172-7. PMID 12414644 |
0.544 |
|
| 2002 |
Mukai M, Kanzaki A, Chen ZS, Miyashita H, Sumizawa T, Furukawa T, Haraguchi M, Takebayashi Y, Takamatsu H, Akiyama S. Enhanced nucleotide excision repair in cisplatin resistant human KB carcinoma cells. Oncology Reports. 9: 839-44. PMID 12066219 DOI: 10.3892/Or.9.4.839 |
0.446 |
|
| 2002 |
Chen ZS, Lee K, Walther S, Raftogianis RB, Kuwano M, Zeng H, Kruh GD. Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Research. 62: 3144-50. PMID 12036927 |
0.419 |
|
| 2001 |
Kruh GD, Zeng H, Rea PA, Liu G, Chen Z, Lee K, Belinsky MG. MRP subfamily transporters and resistance to anticancer agents. Journal of Bioenergetics and Biomembranes. 33: 493-501. PMID 11804191 DOI: 10.1023/A:1012827221844 |
0.608 |
|
| 2001 |
Murakami T, Shibuya I, Ise T, Chen Z, Akiyama S, Nakagawa M, Izumi H, Nakamura T, Matsuo K, Yamada Y, Kohno K. Elevated expression of vacuolar proton pump genes and cellular PH in cisplatin resistance. International Journal of Cancer. 93: 869-874. PMID 11519050 DOI: 10.1002/Ijc.1418 |
0.51 |
|
| 2001 |
Aoki S, Chen ZS, Higasiyama K, Setiawan A, Akiyama SI, Kobayashi M. Reversing effect of agosterol A, a spongean sterol acetate, on multidrug resistance in human carcinoma cells Japanese Journal of Cancer Research. 92: 886-895. PMID 11509122 DOI: 10.1111/J.1349-7006.2001.Tb01177.X |
0.577 |
|
| 2001 |
Chen ZS, Lee K, Kruh GD. Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine. The Journal of Biological Chemistry. 276: 33747-54. PMID 11447229 DOI: 10.1074/Jbc.M104833200 |
0.517 |
|
| 2001 |
Chen ZS, Aoki S, Komatsu M, Ueda K, Sumizawa T, Furukawa T, Okumura H, Ren XQ, Belinsky MG, Lee K, Kruh GD, Kobayashi M, Akiyama SI. Reversal of drug resistance mediated by multidrug resistance protein (MRP) 1 by dual effects of agosterol a on MRP1 function International Journal of Cancer. 93: 107-113. PMID 11391629 DOI: 10.1002/Ijc.1290 |
0.614 |
|
| 2001 |
Ren XQ, Furukawa T, Aoki S, Nakajima T, Sumizawa T, Haraguchi M, Chen ZS, Kobayashi M, Akiyama SI. Glutathione-dependent Binding of a Photoaffinity Analog of Agosterol A to the C-terminal Half of Human Multidrug Resistance Protein Journal of Biological Chemistry. 276: 23197-23206. PMID 11301332 DOI: 10.1074/Jbc.M101554200 |
0.527 |
|
| 2000 |
Okumura H, Chen Z, Sakou M, Sumizawa T, Furukawa T, Komatsu M, Ikeda R, Suzuki H, Hirota K, Aikou T, Akiyama S. Reversal of P-glycoprotein and multidrug-resistance protein-mediated drug resistance in KB cells by 5-O-benzoylated taxinine K. Molecular Pharmacology. 58: 1563-1569. PMID 11093797 DOI: 10.1124/Mol.58.6.1563 |
0.586 |
|
| 2000 |
Kobayashi J, Shigemori H, Hosoyama H, Chen Z, Akiyama S, Naito M, Tsuruo T. Multidrug resistance reversal activity of taxoids from Taxus cuspidata in KB-C2 and 2780AD cells. Japanese Journal of Cancer Research. 91: 638-642. PMID 10874217 DOI: 10.1111/J.1349-7006.2000.Tb00993.X |
0.493 |
|
| 2000 |
Ren X, Furukawa T, Chen Z, Okumura H, Aoki S, Sumizawa T, Tani A, Komatsu M, Mei X, Akiyama S. Functional Comparison between YCF1 and MRP1 Expressed in Sf21 Insect Cells Biochemical and Biophysical Research Communications. 270: 608-615. PMID 10753671 DOI: 10.1006/Bbrc.2000.2483 |
0.588 |
|
| 1999 |
Chen Z, Kawabe T, Ono M, Aoki S, Sumizawa T, Furukawa T, Uchiumi T, Wada M, Kuwano M, Akiyama S. Effect of Multidrug Resistance-Reversing Agents on Transporting Activity of Human Canalicular Multispecific Organic Anion Transporter Molecular Pharmacology. 56: 1219-1228. PMID 10570049 DOI: 10.1124/Mol.56.6.1219 |
0.588 |
|
| 1999 |
Kitazono M, Sumizawa T, Takebayashi Y, Chen ZS, Furukawa T, Nagayama S, Tani A, Takao S, Aikou T, Akiyama S. Multidrug resistance and the lung resistance-related protein in human colon carcinoma SW-620 cells. Journal of the National Cancer Institute. 91: 1647-53. PMID 10511592 DOI: 10.1093/Jnci/91.19.1647 |
0.596 |
|
| 1999 |
Kawabe T, Chen Z, Wada M, Uchiumi T, Ono M, Akiyama S, Kuwano M. Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2). Febs Letters. 456: 327-331. PMID 10456333 DOI: 10.1016/S0014-5793(99)00979-5 |
0.472 |
|
| 1999 |
Chen Z, Sumizawa T, Furukawa T, Ono K, Tani A, Komatsu M, Akiyama S. An enhanced active efflux of CPT-11 and SN-38 in cisplatin-resistant human KB carcinoma cells. Cancer Letters. 138: 13-22. PMID 10378768 DOI: 10.1016/S0304-3835(98)00367-X |
0.567 |
|
| 1999 |
Aoki S, Setiawan A, Yoshioka Y, Higuchi K, Fudetani R, Chen Z, Sumizawa T, Akiyama S, Kobayashi M. Reversal of multidrug resistance in human carcinoma cell line by agosterols, marine spongean sterols Tetrahedron. 55: 13965-13972. DOI: 10.1016/S0040-4020(99)00870-4 |
0.473 |
|
| 1998 |
Nagayama S, Chen ZS, Kitazono M, Takebayashi Y, Niwa K, Yamada K, Tani A, Haraguchi M, Sumizawa T, Furukawa T, Aikou T, Akiyama S. Increased sensitivity to vincristine of MDR cells by the leukotriene D4 receptor antagonist, ONO-1078. Cancer Letters. 130: 175-82. PMID 9751271 DOI: 10.1016/S0304-3835(98)00132-3 |
0.551 |
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| 1998 |
Chuman Y, Chen Z, Seto K, Sumizawa T, Furukawa T, Tani A, Haraguchi M, Niwa K, Yamada K, Aikou T, Akiyama S. Reversal of MRP-mediated vincristine resistance in KB cells by buthionine sulfoximine in combination with PAK-104P Cancer Letters. 129: 69-76. PMID 9714337 DOI: 10.1016/S0304-3835(98)00083-4 |
0.546 |
|
| 1998 |
Chen Z, Mutoh M, Sumizawa T, Furukawa T, Haraguchi M, Tani A, Saijo N, Kondo T, Akiyama S. An active efflux system for heavy metals in cisplatin-resistant human KB carcinoma cells. Experimental Cell Research. 240: 312-320. PMID 9597004 DOI: 10.1006/Excr.1998.3938 |
0.516 |
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| 1998 |
Aoki S, Yoshioka Y, Miyamoto Y, Higuchi K, Setiawan A, Murakami N, Chen Z, Sumizawa T, Akiyama S, Kobayashi M. Agosterol A, a novel polyhydroxylated sterol acetate reversing multidrug resistance from a marine sponge of Spongia sp. Tetrahedron Letters. 39: 6303-6306. DOI: 10.1016/S0040-4039(98)01336-7 |
0.47 |
|
| 1997 |
Chen Z, Mutoh M, Sumizawa T, Furukawa T, Haraguchi M, Tani A, Akiyama S. Reversal of heavy metal resistance in multidrug-resistant human KB carcinoma cells. Biochemical and Biophysical Research Communications. 236: 586-590. PMID 9245693 DOI: 10.1006/Bbrc.1997.7015 |
0.529 |
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| 1996 |
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0.564 |
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| Show low-probability matches. |