Jan Grunewald - Publications

Affiliations: 
Genomics Institute of the Novartis Research Foundation 
Area:
Antibody-Drug Conjugates, Protein/Antibody Engineering, Conjugation Strategies, Genetic Code Expansion, Secondary Metabolite Engineering, Enzymology, Peptide Chemistry

17 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Grünewald J, Brock A, Geierstanger BH. Site-Specific Antibody Labeling Using Phosphopantetheinyl Transferase-Catalyzed Ligation. Methods in Molecular Biology (Clifton, N.J.). 2012: 237-278. PMID 31161512 DOI: 10.1007/978-1-4939-9546-2_13  0.542
2017 Grunewald J, Jin Y, Vance J, Read J, Wang X, Wan Y, Zhou H, Ou W, Klock HE, Peters EC, Uno T, Brock A, Geierstanger BH. Optimization of an Enzymatic Antibody Drug Conjugation Approach based on CoA Analogs. Bioconjugate Chemistry. PMID 28590752 DOI: 10.1021/Acs.Bioconjchem.7B00236  0.694
2015 Grunewald J, Klock HE, Cellitti SE, Bursulaya B, McMullan D, Jones DH, Chiu HP, Wang X, Patterson P, Zhou H, Vance J, Nigoghossian E, Tong H, Daniel D, Mallet W, et al. Efficient preparation of site-specific antibody-drug conjugates using phosphopantetheinyl transferases. Bioconjugate Chemistry. PMID 26588668 DOI: 10.1021/Acs.Bioconjchem.5B00558  0.666
2015 Venable JD, Steckler C, Ou W, Grünewald J, Agarwalla S, Brock A. Isotope-Coded Labeling for Accelerated Protein Interaction Profiling Using MS. Analytical Chemistry. 87: 7540-4. PMID 26151661 DOI: 10.1021/Acs.Analchem.5B01410  0.311
2012 Chiu HP, Grünewald J, Hao X, Brock A, Okach L, Uno T, Geierstanger BH. Simultaneous purification and site-specific modification of pyrroline-carboxy-lysine proteins. Chembiochem : a European Journal of Chemical Biology. 13: 364-6. PMID 22223621 DOI: 10.1002/Cbic.201100684  0.77
2011 Gauba V, Grünewald J, Gorney V, Deaton LM, Kang M, Bursulaya B, Ou W, Lerner RA, Schmedt C, Geierstanger BH, Schultz PG, Ramirez-Montagut T. Loss of CD4 T-cell-dependent tolerance to proteins with modified amino acids. Proceedings of the National Academy of Sciences of the United States of America. 108: 12821-6. PMID 21768354 DOI: 10.1073/Pnas.1110042108  0.713
2011 Ou W, Uno T, Chiu HP, Grünewald J, Cellitti SE, Crossgrove T, Hao X, Fan Q, Quinn LL, Patterson P, Okach L, Jones DH, Lesley SA, Brock A, Geierstanger BH. Site-specific protein modifications through pyrroline-carboxy-lysine residues. Proceedings of the National Academy of Sciences of the United States of America. 108: 10437-42. PMID 21670250 DOI: 10.1073/Pnas.1105197108  0.782
2011 Cellitti SE, Ou W, Chiu HP, Grünewald J, Jones DH, Hao X, Fan Q, Quinn LL, Ng K, Anfora AT, Lesley SA, Uno T, Brock A, Geierstanger BH. D-Ornithine coopts pyrrolysine biosynthesis to make and insert pyrroline-carboxy-lysine. Nature Chemical Biology. 7: 528-30. PMID 21525873 DOI: 10.1038/Nchembio.586  0.728
2008 Grünewald J, Tsao ML, Perera R, Dong L, Niessen F, Wen BG, Kubitz DM, Smider VV, Ruf W, Nasoff M, Lerner RA, Schultz PG. Immunochemical termination of self-tolerance. Proceedings of the National Academy of Sciences of the United States of America. 105: 11276-80. PMID 18685087 DOI: 10.1073/Pnas.0804157105  0.762
2006 Kopp F, Mahlert C, Grünewald J, Marahiel MA. Peptide macrocyclization: the reductase of the nostocyclopeptide synthetase triggers the self-assembly of a macrocyclic imine. Journal of the American Chemical Society. 128: 16478-9. PMID 17177378 DOI: 10.1021/Ja0667458  0.385
2006 Kopp F, Grünewald J, Mahlert C, Marahiel MA. Chemoenzymatic design of acidic lipopeptide hybrids: new insights into the structure-activity relationship of daptomycin and A54145. Biochemistry. 45: 10474-81. PMID 16939199 DOI: 10.1021/Bi0609422  0.412
2006 Grünewald J, Marahiel MA. Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides. Microbiology and Molecular Biology Reviews : Mmbr. 70: 121-46. PMID 16524919 DOI: 10.1128/Mmbr.70.1.121-146.2006  0.444
2006 Grunewald J, Mahlert C, Kopp F, Marahiel MA. Chemoenzymatic Pathways towards Novel Peptide Antibiotics Anti-Infective Agents in Medicinal Chemistry. 5: 227-243. DOI: 10.2174/187152106777697835  0.314
2005 Grünewald J, Kopp F, Mahlert C, Linne U, Sieber SA, Marahiel MA. Fluorescence resonance energy transfer as a probe of peptide cyclization catalyzed by nonribosomal thioesterase domains. Chemistry & Biology. 12: 873-81. PMID 16125099 DOI: 10.1016/J.Chembiol.2005.05.019  0.404
2005 Mahlert C, Sieber SA, Grünewald J, Marahiel MA. Chemoenzymatic approach to enantiopure streptogramin B variants: characterization of stereoselective pristinamycin I cyclase from Streptomyces pristinaespiralis. Journal of the American Chemical Society. 127: 9571-80. PMID 15984884 DOI: 10.1021/Ja051254T  0.403
2004 Grünewald J, Sieber SA, Mahlert C, Linne U, Marahiel MA. Synthesis and derivatization of daptomycin: a chemoenzymatic route to acidic lipopeptide antibiotics. Journal of the American Chemical Society. 126: 17025-31. PMID 15612741 DOI: 10.1021/Ja045455T  0.462
2004 Grünewald J, Sieber SA, Marahiel MA. Chemo- and regioselective peptide cyclization triggered by the N-terminal fatty acid chain length: the recombinant cyclase of the calcium-dependent antibiotic from Streptomyces coelicolor. Biochemistry. 43: 2915-25. PMID 15005627 DOI: 10.1021/Bi036140D  0.434
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