| Year |
Citation |
Score |
| 2024 |
Shiau C, Cao J, Gong D, Gregory MT, Caldwell NJ, Yin X, Cho JW, Wang PL, Su J, Wang S, Reeves JW, Kim TK, Kim Y, Guo JA, Lester NA, ... ... Jacks T, et al. Spatially resolved analysis of pancreatic cancer identifies therapy-associated remodeling of the tumor microenvironment. Nature Genetics. PMID 39227743 DOI: 10.1038/s41588-024-01890-9 |
0.493 |
|
| 2024 |
Shanahan SL, Kunder N, Inaku C, Hagan NB, Gibbons G, Mathey-Andrews N, Anandappa G, Soares S, Pauken KE, Jacks T, Schenkel JM. Longitudinal Intravascular Antibody Labeling Identified Regulatory T Cell Recruitment as a Therapeutic Target in a Mouse Model of Lung Cancer. Journal of Immunology (Baltimore, Md. : 1950). PMID 39082930 DOI: 10.4049/jimmunol.2400268 |
0.517 |
|
| 2024 |
Mazur PK, Herner A, Mello SS, Wirth M, Hausmann S, Sánchez-Rivera FJ, Lofgren SM, Kuschma T, Hahn SA, Vangala D, Trajkovic-Arsic M, Gupta A, Heid I, Noël PB, Braren R, ... ... Jacks T, et al. Author Correction: Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. Nature Medicine. PMID 38816611 DOI: 10.1038/s41591-024-03054-y |
0.762 |
|
| 2024 |
Boehm JS, Jacks T. Radical Collaboration: Reimagining Cancer Team Science. Cancer Discovery. 14: 563-568. PMID 38571417 DOI: 10.1158/2159-8290.CD-23-1496 |
0.424 |
|
| 2024 |
Sweet-Cordero E, Marini K, Champion E, Lee A, Young I, Leung S, Mathey-Andrews N, Jacks T, Jackson P, Cochran J. The CLCF1-CNTFR axis drives an immunosuppressive tumor microenvironment and blockade enhances the effects of established cancer therapies. Research Square. PMID 38562778 DOI: 10.21203/rs.3.rs-4046823/v1 |
0.546 |
|
| 2024 |
Flores ER, Tsai KY, Crowley D, Sengupta S, Yang A, McKeon F, Jacks T. Editorial Expression of Concern: p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature. PMID 38418890 DOI: 10.1038/s41586-024-07223-4 |
0.442 |
|
| 2024 |
Goto N, Westcott PMK, Goto S, Imada S, Taylor MS, Eng G, Braverman J, Deshpande V, Jacks T, Agudo J, Yilmaz ÖH. SOX17 enables immune evasion of early colorectal adenomas and cancers. Nature. PMID 38418875 DOI: 10.1038/s41586-024-07135-3 |
0.493 |
|
| 2024 |
Weng C, Yu F, Yang D, Poeschla M, Liggett LA, Jones MG, Qiu X, Wahlster L, Caulier A, Hussmann JA, Schnell A, Yost KE, Koblan L, Martin-Rufino JD, Min J, ... ... Jacks T, et al. Deciphering cell states and genealogies of human hematopoiesis. Nature. PMID 38253266 DOI: 10.1038/s41586-024-07066-z |
0.462 |
|
| 2024 |
Zhong Q, Tan EKW, Martin-Alonso C, Parisi T, Hao L, Kirkpatrick JD, Fadel T, Fleming HE, Jacks T, Bhatia SN. Inhalable point-of-care urinary diagnostic platform. Science Advances. 10: eadj9591. PMID 38181080 DOI: 10.1126/sciadv.adj9591 |
0.479 |
|
| 2023 |
Westcott PMK, Muyas F, Hauck H, Smith OC, Sacks NJ, Ely ZA, Jaeger AM, Rideout WM, Zhang D, Bhutkar A, Beytagh MC, Canner DA, Jaramillo GC, Bronson RT, Naranjo S, ... ... Jacks T, et al. Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity. Nature Genetics. PMID 37709863 DOI: 10.1038/s41588-023-01499-4 |
0.533 |
|
| 2023 |
Shiau C, Cao J, Gregory MT, Gong D, Yin X, Cho JW, Wang PL, Su J, Wang S, Reeves JW, Kim TK, Kim Y, Guo JA, Lester NA, Schurman N, ... ... Jacks T, et al. Therapy-associated remodeling of pancreatic cancer revealed by single-cell spatial transcriptomics and optimal transport analysis. Biorxiv : the Preprint Server For Biology. PMID 37425692 DOI: 10.1101/2023.06.28.546848 |
0.483 |
|
| 2023 |
Ely ZA, Mathey-Andrews N, Naranjo S, Gould SI, Mercer KL, Newby GA, Cabana CM, Rideout WM, Jaramillo GC, Khirallah JM, Holland K, Randolph PB, Freed-Pastor WA, Davis JR, Kulstad Z, ... ... Jacks T, et al. A prime editor mouse to model a broad spectrum of somatic mutations in vivo. Nature Biotechnology. PMID 37169967 DOI: 10.1038/s41587-023-01783-y |
0.817 |
|
| 2023 |
Gaglia G, Burger ML, Ritch CC, Rammos D, Dai Y, Crossland GE, Tavana SZ, Warchol S, Jaeger AM, Naranjo S, Coy S, Nirmal AJ, Krueger R, Lin JR, Pfister H, ... ... Jacks T, et al. Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma. Cancer Cell. PMID 37059105 DOI: 10.1016/j.ccell.2023.03.015 |
0.489 |
|
| 2023 |
Hill W, Lim EL, Weeden CE, Lee C, Augustine M, Chen K, Kuan FC, Marongiu F, Evans EJ, Moore DA, Rodrigues FS, Pich O, Bakker B, Cha H, Myers R, ... ... Jacks T, et al. Lung adenocarcinoma promotion by air pollutants. Nature. 616: 159-167. PMID 37020004 DOI: 10.1038/s41586-023-05874-3 |
0.641 |
|
| 2022 |
Amini AP, Kirkpatrick JD, Wang CS, Jaeger AM, Su S, Naranjo S, Zhong Q, Cabana CM, Jacks T, Bhatia SN. Multiscale profiling of protease activity in cancer. Nature Communications. 13: 5745. PMID 36192379 DOI: 10.1038/s41467-022-32988-5 |
0.497 |
|
| 2022 |
Naranjo S, Cabana CM, LaFave LM, Romero R, Shanahan SL, Bhutkar A, Westcott PMK, Schenkel JM, Ghosh A, Liao LZ, Del Priore I, Yang D, Jacks T. Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platform. Genes & Development. PMID 36175034 DOI: 10.1101/gad.349659.122 |
0.82 |
|
| 2022 |
Warchol S, Krueger R, Nirmal AJ, Gaglia G, Jessup J, Ritch CC, Hoffer J, Muhlich J, Burger ML, Jacks T, Santagata S, Sorger PK, Pfister H. Visinity: Visual Spatial Neighborhood Analysis for Multiplexed Tissue Imaging Data. Ieee Transactions On Visualization and Computer Graphics. PMID 36170403 DOI: 10.1109/TVCG.2022.3209378 |
0.457 |
|
| 2022 |
Hwang WL, Jagadeesh KA, Guo JA, Hoffman HI, Yadollahpour P, Reeves JW, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi SL, Schapiro D, Divakar P, Miller E, Zollinger DR, ... ... Jacks T, et al. Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment. Nature Genetics. PMID 35902743 DOI: 10.1038/s41588-022-01134-8 |
0.464 |
|
| 2022 |
Jaeger AM, Stopfer LE, Ahn R, Sanders EA, Sandel DA, Freed-Pastor WA, Rideout WM, Naranjo S, Fessenden T, Nguyen KB, Winter PS, Kohn RE, Westcott PMK, Schenkel JM, Shanahan SL, ... ... Jacks T, et al. Deciphering the immunopeptidome in vivo reveals new tumour antigens. Nature. PMID 35705813 DOI: 10.1038/s41586-022-04839-2 |
0.44 |
|
| 2022 |
Yang D, Jones MG, Naranjo S, Rideout WM, Min KHJ, Ho R, Wu W, Replogle JM, Page JL, Quinn JJ, Horns F, Qiu X, Chen MZ, Freed-Pastor WA, McGinnis CS, ... ... Jacks T, et al. Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution. Cell. PMID 35523183 DOI: 10.1016/j.cell.2022.04.015 |
0.517 |
|
| 2022 |
Romero R, Sánchez-Rivera FJ, Westcott PMK, Mercer KL, Bhutkar A, Muir A, González Robles TJ, Rodríguez SL, Liao LZ, Ng SR, Li L, Colón CI, Naranjo S, Beytagh MC, Lewis CA, ... ... Jacks T, et al. Publisher Correction: Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1. Nature Cancer. 1: 935. PMID 35121957 DOI: 10.1038/s43018-020-00118-z |
0.793 |
|
| 2022 |
Shi DD, Guo JA, Hoffman HI, Su J, Mino-Kenudson M, Barth JL, Schenkel JM, Loeffler JS, Shih HA, Hong TS, Wo JY, Aguirre AJ, Jacks T, Zheng L, Wen PY, et al. Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities. The Lancet. Oncology. 23: e62-e74. PMID 35114133 DOI: 10.1016/S1470-2045(21)00596-9 |
0.435 |
|
| 2022 |
Patel RS, Romero R, Watson EV, Liang AC, Burger M, Westcott PMK, Mercer KL, Bronson RT, Wooten EC, Bhutkar A, Jacks T, Elledge SJ. A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells. Nature Communications. 13: 256. PMID 35017504 DOI: 10.1038/s41467-021-27731-5 |
0.811 |
|
| 2021 |
Zhao T, Chiang ZD, Morriss JW, LaFave LM, Murray EM, Del Priore I, Meli K, Lareau CA, Nadaf NM, Li J, Earl AS, Macosko EZ, Jacks T, Buenrostro JD, Chen F. Spatial genomics enables multi-modal study of clonal heterogeneity in tissues. Nature. PMID 34912115 DOI: 10.1038/s41586-021-04217-4 |
0.455 |
|
| 2021 |
Raghavan S, Winter PS, Navia AW, Williams HL, DenAdel A, Lowder KE, Galvez-Reyes J, Kalekar RL, Mulugeta N, Kapner KS, Raghavan MS, Borah AA, Liu N, Väyrynen SA, Costa AD, ... ... Jacks TE, et al. Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer. Cell. 184: 6119-6137.e26. PMID 34890551 DOI: 10.1016/j.cell.2021.11.017 |
0.587 |
|
| 2021 |
Westcott PMK, Sacks NJ, Schenkel JM, Ely ZA, Smith O, Hauck H, Jaeger AM, Zhang D, Backlund CM, Beytagh MC, Patten JJ, Elbashir R, Eng G, Irvine DJ, Yilmaz OH, ... Jacks T, et al. Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer. Nature Cancer. 2: 1071-1085. PMID 34738089 DOI: 10.1038/s43018-021-00247-z |
0.5 |
|
| 2021 |
Hamza B, Miller AB, Meier L, Stockslager M, Ng SR, King EM, Lin L, DeGouveia KL, Mulugeta N, Calistri NL, Strouf H, Bray C, Rodriguez F, Freed-Pastor WA, Chin CR, ... ... Jacks T, et al. Measuring kinetics and metastatic propensity of CTCs by blood exchange between mice. Nature Communications. 12: 5680. PMID 34584084 DOI: 10.1038/s41467-021-25917-5 |
0.688 |
|
| 2021 |
Concepcion CP, Ma S, LaFave LM, Bhutkar A, Liu M, DeAngelo LP, Kim JY, Del Priore I, Schoenfeld AJ, Miller M, Kartha VK, Westcott PMK, Sanchez-Rivera FJ, Meli K, Gupta M, ... ... Jacks T, et al. SMARCA4 inactivation promotes lineage-specific transformation and early metastatic features in the lung. Cancer Discovery. PMID 34561242 DOI: 10.1158/2159-8290.CD-21-0248 |
0.827 |
|
| 2021 |
Burger ML, Cruz AM, Crossland GE, Gaglia G, Ritch CC, Blatt SE, Bhutkar A, Canner D, Kienka T, Tavana SZ, Barandiaran AL, Garmilla A, Schenkel JM, Hillman M, de Los Rios Kobara I, ... ... Jacks T, et al. Antigen dominance hierarchies shape TCF1 progenitor CD8 T cell phenotypes in tumors. Cell. 184: 4996-5014.e26. PMID 34534464 DOI: 10.1016/j.cell.2021.08.020 |
0.485 |
|
| 2021 |
Schenkel JM, Herbst RH, Canner D, Li A, Hillman M, Shanahan SL, Gibbons G, Smith OC, Kim JY, Westcott P, Hwang WL, Freed-Pastor WA, Eng G, Cuoco MS, Rogers P, ... ... Jacks T, et al. Conventional type I dendric cells maintain a reservoir of proliferative tumor-antigen specific TCF-1 CD8 T cells in tumor-draining lymph nodes. Immunity. PMID 34534439 DOI: 10.1016/j.immuni.2021.08.026 |
0.463 |
|
| 2021 |
Genshaft AS, Ziegler CGK, Tzouanas CN, Mead BE, Jaeger AM, Navia AW, King RP, Mana MD, Huang S, Mitsialis V, Snapper SB, Yilmaz ÖH, Jacks T, Van Humbeck JF, Shalek AK. Publisher Correction: Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes. Nature Communications. 12: 5361. PMID 34480027 DOI: 10.1038/s41467-021-25672-7 |
0.413 |
|
| 2021 |
Genshaft AS, Ziegler CGK, Tzouanas CN, Mead BE, Jaeger AM, Navia AW, King RP, Mana MD, Huang S, Mitsialis V, Snapper SB, Yilmaz ÖH, Jacks T, Van Humbeck JF, Shalek AK. Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes. Nature Communications. 12: 4995. PMID 34404785 DOI: 10.1038/s41467-021-25279-y |
0.484 |
|
| 2021 |
Freed-Pastor WA, Lambert LJ, Ely ZA, Pattada NB, Bhutkar A, Eng G, Mercer KL, Garcia AP, Lin L, Rideout WM, Hwang WL, Schenkel JM, Jaeger AM, Bronson RT, Westcott PMK, ... ... Jacks T, et al. The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer. Cancer Cell. PMID 34358448 DOI: 10.1016/j.ccell.2021.07.007 |
0.426 |
|
| 2021 |
Ciampricotti M, Karakousi T, Richards AL, Quintanal-Villalonga A, Karatza A, Caeser R, Costa EA, Allaj V, Manoj P, Spainhower KB, Kombak FE, Sanchez-Rivera FJ, Jaspers JE, Zavitsanou AM, Maddalo D, ... ... Jacks T, et al. Rlf-Mycl gene fusion drives tumorigenesis and metastasis in a mouse model of small cell lung cancer. Cancer Discovery. PMID 34344693 DOI: 10.1158/2159-8290.CD-21-0441 |
0.833 |
|
| 2021 |
Hajal C, Shin Y, Li L, Serrano JC, Jacks T, Kamm RD. The CCL2-CCR2 astrocyte-cancer cell axis in tumor extravasation at the brain. Science Advances. 7. PMID 34162553 DOI: 10.1126/sciadv.abg8139 |
0.469 |
|
| 2021 |
Del Priore I, Ma S, Strecker J, Jacks T, LaFave LM, Buenrostro JD. Protocol for single-cell ATAC sequencing using combinatorial indexing in mouse lung adenocarcinoma. Star Protocols. 2: 100583. PMID 34142101 DOI: 10.1016/j.xpro.2021.100583 |
0.448 |
|
| 2021 |
Lussier DM, Alspach E, Ward JP, Miceli AP, Runci D, White JM, Mpoy C, Arthur CD, Kohlmiller HN, Jacks T, Artyomov MN, Rogers BE, Schreiber RD. Radiation-induced neoantigens broaden the immunotherapeutic window of cancers with low mutational loads. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34099555 DOI: 10.1073/pnas.2102611118 |
0.534 |
|
| 2021 |
Sánchez-Rivera FJ, Ryan J, Soto-Feliciano YM, Clare Beytagh M, Xuan L, Feldser DM, Hemann MT, Zamudio J, Dimitrova N, Letai A, Jacks T. Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34074758 DOI: 10.1073/pnas.2019740118 |
0.817 |
|
| 2021 |
Guo JA, Hoffman HI, Shroff S, Chen P, Hwang PG, Kim DY, Kim DW, Cheng SW, Zhao D, Mahal BA, Alshalalfa M, Niemierko A, Wo JY, Loeffler JS, Fernandez-Del Castillo C, ... Jacks T, et al. Pan-cancer transcriptomic predictors of perineural invasion improve occult histopathological detection. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 33632928 DOI: 10.1158/1078-0432.CCR-20-4382 |
0.435 |
|
| 2020 |
Romero R, Sánchez-Rivera FJ, Westcott PMK, Mercer KL, Bhutkar A, Muir A, González-Robles TJ, Lamboy-Rodríguez SA, Liao LZ, Ng SR, Li L, Colón CI, Naranjo S, Beytagh MC, Lewis CA, ... ... Jacks T, et al. Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1. Nature Cancer. 1: 589-602. PMID 34414377 DOI: 10.1038/s43018-020-0071-1 |
0.82 |
|
| 2020 |
Damo M, Fitzgerald B, Lu Y, Nader M, William I, Cheung JF, Connolly KA, Foster GG, Akama-Garren E, Lee DY, Chang GP, Gocheva V, Schmidt LM, Boileve A, Wilson JH, ... ... Jacks T, et al. Inducible de novo expression of neoantigens in tumor cells and mice. Nature Biotechnology. PMID 32719479 DOI: 10.1038/S41587-020-0613-1 |
0.557 |
|
| 2020 |
Schoenfeld AJ, Bandlamudi C, Lavery JA, Montecalvo J, Namakydoust A, Rizvi H, Egger JV, Concepcion CP, Paul S, Arcila ME, Daneshbod Y, Chang JC, Sauter JL, Beras A, Ladanyi M, ... Jacks T, et al. The Genomic Landscape of Alterations and Associations with Outcomes in Patients with Lung Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 32709715 DOI: 10.1158/1078-0432.Ccr-20-1825 |
0.529 |
|
| 2020 |
LaFave LM, Kartha VK, Ma S, Meli K, Del Priore I, Lareau C, Naranjo S, Westcott PMK, Duarte FM, Sankar V, Chiang Z, Brack A, Law T, Hauck H, Okimoto A, ... ... Jacks T, et al. Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma. Cancer Cell. PMID 32707078 DOI: 10.1016/J.Ccell.2020.06.006 |
0.56 |
|
| 2020 |
Marjanovic ND, Hofree M, Chan JE, Canner D, Wu K, Trakala M, Hartmann GG, Smith OC, Kim JY, Evans KV, Hudson A, Ashenberg O, Porter CBM, Bejnood A, Subramanian A, ... ... Jacks T, et al. Emergence of a High-Plasticity Cell State during Lung Cancer Evolution. Cancer Cell. PMID 32707077 DOI: 10.1016/J.Ccell.2020.06.012 |
0.617 |
|
| 2020 |
Gupta M, Concepcion CP, Fahey CG, Keshishian H, Bhutkar A, Brainson CF, Sanchez-Rivera FJ, Pessina P, Kim JY, Simoneau A, Paschini M, Beytagh MC, Stanclift CR, Schenone M, Mani DR, ... ... Jacks T, et al. BRG1 loss predisposes lung cancers to replicative stress and ATR dependency. Cancer Research. PMID 32690724 DOI: 10.1158/0008-5472.Can-20-1744 |
0.811 |
|
| 2020 |
Lau AN, Li Z, Danai LV, Westermark AM, Darnell AM, Ferreira R, Gocheva V, Sivanand S, Lien EC, Sapp KM, Mayers JR, Biffi G, Chin CR, Davidson SM, Tuveson DA, ... Jacks T, et al. Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma. Elife. 9. PMID 32648540 DOI: 10.7554/Elife.56782 |
0.809 |
|
| 2020 |
Chung KM, Singh J, Lawres L, Dorans KJ, Garcia C, Burkhardt DB, Robbins R, Bhutkar A, Cardone R, Zhao X, Babic A, Vayrynen SA, Dias Costa A, Nowak JA, Chang DT, ... ... Jacks T, et al. Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma. Cell. PMID 32304665 DOI: 10.1016/J.Cell.2020.03.062 |
0.488 |
|
| 2020 |
Kirkpatrick JD, Warren AD, Soleimany AP, Westcott PMK, Voog JC, Martin-Alonso C, Fleming HE, Tammela T, Jacks T, Bhatia SN. Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling. Science Translational Medicine. 12. PMID 32238573 DOI: 10.1126/Scitranslmed.Aaw0262 |
0.551 |
|
| 2020 |
Lau AN, Li Z, Danai LV, Westermark AM, Darnell AM, Ferreira R, Gocheva V, Sivanand S, Lien EC, Sapp KM, Mayers JR, Biffi G, Chin CR, Davidson SM, Tuveson DA, ... Jacks T, et al. Author response: Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma Elife. DOI: 10.7554/Elife.56782.Sa2 |
0.774 |
|
| 2020 |
Hwang WL, Jagadeesh K, Guo J, Hoffman HI, Ashenberg O, Drokhlyansky E, Van Wittenberghe N, Farhi S, Schapiro D, Rodrigues C, Ciprani D, Zollinger D, Hong TS, Aguirre A, Mino-Kenudson M, ... ... Jacks T, et al. Single-nucleus RNA-seq of frozen archival primary pancreatic ductal adenocarcinoma uncovers multi-compartment intratumoral heterogeneity associated with neoadjuvant treatment. Journal of Clinical Oncology. 38: 4633-4633. DOI: 10.1200/Jco.2020.38.15_Suppl.4633 |
0.527 |
|
| 2020 |
Jin C, Zhao C, Lagoudas G, Bhutkar A, Hu B, Jacks T. Abstract A63: Commensal microbiota promote lung tumorigenesis via γδ T cells Cancer Immunology Research. 8. DOI: 10.1158/2326-6074.Tumimm18-A63 |
0.585 |
|
| 2020 |
LaFave LM, Kartha V, Ma S, Meli K, Priore ID, Lareau C, Sanker V, Naranjo S, Westcott P, Chiang Z, Brack A, Law T, Regev A, Buenrostro JD, Jacks T. Abstract PR08: Leveraging single-cell epigenomics to uncover regulatory programs in lung adenocarcinoma Cancer Research. 80. DOI: 10.1158/1538-7445.Camodels2020-Pr08 |
0.614 |
|
| 2020 |
Chan JE, Marjanovic ND, Hofree M, Canner D, Wu K, Hartmann G, Smith OC, Kim J, Hudson A, Subramanian A, Pitter K, Rekhtman N, Massion PP, Poirier JT, Rudin CM, ... Jacks T, et al. Abstract 1511: A highly plastic cell state emerges during lung adenocarcinoma evolution Tumor Biology. DOI: 10.1158/1538-7445.Am2020-1511 |
0.522 |
|
| 2020 |
Romero R, Sánchez-Rivera FJ, Westcott PMK, Mercer KL, Bhutkar A, Muir A, González Robles TJ, Lamboy Rodríguez S, Liao LZ, Ng SR, Li L, Colón CI, Naranjo S, Beytagh MC, Lewis CA, ... ... Jacks T, et al. Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1 Nature Cancer. 1: 589-602. DOI: 10.1038/s43018-020-0071-1 |
0.798 |
|
| 2019 |
Ng SR, Rideout WM, Akama-Garren EH, Bhutkar A, Mercer KL, Schenkel JM, Bronson RT, Jacks T. CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 31871154 DOI: 10.1073/Pnas.1821893117 |
0.563 |
|
| 2019 |
Li A, Herbst RH, Canner D, Schenkel JM, Smith OC, Kim JY, Hillman M, Bhutkar A, Cuoco MS, Rappazzo CG, Rogers P, Dang C, Jerby-Arnon L, Rozenblatt-Rosen O, Cong L, ... ... Jacks T, et al. IL-33 Signaling Alters Regulatory T Cell Diversity in Support of Tumor Development. Cell Reports. 29: 2998-3008.e8. PMID 31801068 DOI: 10.1016/J.Celrep.2019.10.120 |
0.539 |
|
| 2019 |
Li L, Ng SR, Colón CI, Drapkin BJ, Hsu PP, Li Z, Nabel CS, Lewis CA, Romero R, Mercer KL, Bhutkar A, Phat S, Myers DT, Muzumdar MD, Westcott PMK, ... ... Jacks T, et al. Identification of DHODH as a therapeutic target in small cell lung cancer. Science Translational Medicine. 11. PMID 31694929 DOI: 10.1126/Scitranslmed.Aaw7852 |
0.824 |
|
| 2019 |
Alspach E, Lussier DM, Miceli AP, Kizhvatov I, DuPage M, Luoma AM, Meng W, Lichti CF, Esaulova E, Vomund AN, Runci D, Ward JP, Gubin MM, Medrano RFV, Arthur CD, ... ... Jacks T, et al. MHC-II neoantigens shape tumour immunity and response to immunotherapy. Nature. PMID 31645760 DOI: 10.1038/S41586-019-1671-8 |
0.487 |
|
| 2019 |
Schmidt L, Eskiocak B, Kohn R, Dang C, Joshi NS, DuPage M, Lee DY, Jacks T. Enhanced adaptive immune responses in lung adenocarcinoma through natural killer cell stimulation. Proceedings of the National Academy of Sciences of the United States of America. PMID 31409707 DOI: 10.1073/Pnas.1904253116 |
0.579 |
|
| 2019 |
Boettcher S, Miller PG, Sharma R, McConkey M, Leventhal M, Krivtsov AV, Giacomelli AO, Wong W, Kim J, Chao S, Kurppa KJ, Yang X, Milenkowic K, Piccioni F, Root DE, ... ... Jacks T, et al. A dominant-negative effect drives selection of missense mutations in myeloid malignancies. Science (New York, N.Y.). 365: 599-604. PMID 31395785 DOI: 10.1126/Science.Aax3649 |
0.657 |
|
| 2019 |
Pentinmikko N, Iqbal S, Mana M, Andersson S, Cognetta AB, Suciu RM, Roper J, Luopajärvi K, Markelin E, Gopalakrishnan S, Smolander OP, Naranjo S, Saarinen T, Juuti A, Pietiläinen K, ... ... Jacks T, et al. Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium. Nature. PMID 31292548 DOI: 10.1038/S41586-019-1383-0 |
0.51 |
|
| 2019 |
Jaeger AM, Stopfer L, Lee S, Gaglia G, Sandel D, Santagata S, Lin NU, Trepel JB, White FM, Jacks T, Lindquist S, Whitesell L. Rebalancing protein homeostasis enhances tumor antigen presentation. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31213460 DOI: 10.1158/1078-0432.Ccr-19-0596 |
0.542 |
|
| 2019 |
Jin C, Lagoudas GK, Zhao C, Bullman S, Bhutkar A, Hu B, Ameh S, Sandel D, Liang XS, Mazzilli S, Whary MT, Meyerson M, Germain R, Blainey PC, Fox JG, ... Jacks T, et al. Commensal Microbiota Promote Lung Cancer Development via γδ T Cells. Cell. PMID 30712876 DOI: 10.1016/J.Cell.2018.12.040 |
0.66 |
|
| 2019 |
Hamza B, Ng SR, Prakadan SM, Delgado FF, Chin CR, King EM, Yang LF, Davidson SM, DeGouveia KL, Cermak N, Navia AW, Winter PS, Drake RS, Tammela T, Li CM, ... ... Jacks T, et al. Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 30674677 DOI: 10.1073/Pnas.1814102116 |
0.547 |
|
| 2019 |
Freed-Pastor WA, Lambert L, Garcia AP, Eng G, Yilmaz O, Jacks T. Abstract PR14: Preclinical models to dissect immune escape in pancreatic cancer Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-Pr14 |
0.549 |
|
| 2019 |
Chung KM, Singh J, Lawres L, Dorans KJ, Robbins R, Bhutkar A, Babic A, Vayrynen SA, Costa AD, Nowak JA, Chang DT, Dunne RF, Hezel AF, Koong AC, Wilhelm JJ, ... ... Jacks T, et al. Abstract A35: Microenvironmental adaptations drive obesity-associated pancreatic cancer Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-A35 |
0.494 |
|
| 2019 |
Westcott PMK, Pitkänen T, Blom S, Westerling T, Ropponen T, Sacks N, Wu K, Bronson R, Tammela T, Jacks T. Abstract 4447: Deep neural network for automatic histopathologic analysis of murine lung tumors Cancer Research. 79: 4447-4447. DOI: 10.1158/1538-7445.Am2019-4447 |
0.585 |
|
| 2018 |
Goggins MG, Lippman SM, Constantinou PE, Jacks T, Petersen GM, Syngal S, Maitra A. Intercepting Pancreatic Cancer: Our Dream Team's Resolve to Stop Pancreatic Cancer. Pancreas. 47: 1175-1176. PMID 30325853 DOI: 10.1097/Mpa.0000000000001165 |
0.489 |
|
| 2018 |
Guimaraes PPG, Tan M, Tammela T, Wu K, Chung A, Oberli M, Wang K, Spektor R, Riley RS, Viana CTR, Jacks T, Langer R, Mitchell MJ. Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 30290244 DOI: 10.1016/J.Jconrel.2018.09.025 |
0.531 |
|
| 2018 |
Lo JH, Hao L, Muzumdar MD, Raghavan S, Kwon EJ, Pulver EM, Hsu F, Aguirre AJ, Wolpin BM, Fuchs CS, Hahn WC, Jacks T, Bhatia SN. iRGD-guided tumor-penetrating nanocomplexes for therapeutic siRNA delivery to pancreatic cancer. Molecular Cancer Therapeutics. PMID 30097486 DOI: 10.1158/1535-7163.Mct-17-1090 |
0.644 |
|
| 2018 |
Dayton TL, Gocheva V, Miller KM, Bhutkar A, Lewis CA, Bronson RT, Vander Heiden MG, Jacks T. Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma. Cancer & Metabolism. 6: 6. PMID 29854399 DOI: 10.1186/S40170-018-0179-2 |
0.53 |
|
| 2018 |
Tao Z, Muzumdar MD, Detappe A, Huang X, Xu E, Yu Y, Mouhieddine TH, Song H, Jacks T, Ghoroghchian PP. Differences in Nanoparticle Uptake in Transplanted and Autochthonous Models of Pancreatic Cancer. Nano Letters. PMID 29533667 DOI: 10.1021/Acs.Nanolett.7B04043 |
0.512 |
|
| 2018 |
Roper J, Tammela T, Akkad A, Almeqdadi M, Santos SB, Jacks T, Yilmaz ÖH. Colonoscopy-based colorectal cancer modeling in mice with CRISPR-Cas9 genome editing and organoid transplantation. Nature Protocols. 13: 217-234. PMID 29300388 DOI: 10.1038/Nprot.2017.136 |
0.581 |
|
| 2018 |
Marjanovic N, Hofree M, Canner D, Trakala M, Wu K, Smith O, Kim J, Amon A, Regev A, Jacks T, Tammela T. Abstract IA34: Targeting cellular heterogeneity in lung adenocarcinoma Clinical Cancer Research. 24. DOI: 10.1158/1557-3265.Aacriaslc18-Ia34 |
0.629 |
|
| 2018 |
Marjanovic ND, Ng SR, Regev A, Jacks T. Abstract A24: Using single-cell RNA-seq approaches to decipher heterogeneity in autochthonous mouse models of small cell lung cancer Clinical Cancer Research. 24. DOI: 10.1158/1557-3265.Aacriaslc18-A24 |
0.599 |
|
| 2018 |
Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli M, Sánchez-Rivera F, Park Y, Liang X, Eng G, Taylor MS, Azimi R, ... ... Jacks T, et al. Abstract B38: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis Cancer Research. 78. DOI: 10.1158/1538-7445.Mousemodels17-B38 |
0.583 |
|
| 2018 |
Romero R, Sayin VI, Shawn DM, Bauer M, Singh SX, LeBoeuf S, Karakousi TR, Ellis DC, Bhutkar A, Sanchez-Rivera F, Subbaraj L, Martinez B, Bronson RT, Prigge JR, Schmidt EE, ... ... Jacks T, et al. Abstract A43: Loss of Keap1 promotes KRAS-driven lung cancer and results in genotype-specific vulnerabilities Cancer Research. 78. DOI: 10.1158/1538-7445.Mousemodels17-A43 |
0.829 |
|
| 2018 |
Ng SR, Rideout WM, Wagner BL, Jacks T. Abstract A12: CRISPR-mediated modeling and functional validation of candidate tumor-suppressor genes in small cell lung cancer Cancer Research. 78. DOI: 10.1158/1538-7445.Mousemodels17-A12 |
0.638 |
|
| 2018 |
Muzumdar MD, Dorans KJ, Chung KM, Bhutkar A, Fuchs C, Jacks T. Abstract A05: Investigating mechanisms of obesity-mediated pancreatic cancer progression Cancer Research. 78. DOI: 10.1158/1538-7445.Mousemodels17-A05 |
0.568 |
|
| 2018 |
Jin AY, Westcott P, Smith O, Cruz A, Beytagh MC, Jacks T. Abstract 4091: Knockout of genes in the DNA mismatch repair pathway to model colorectal cancer hypermutation Cancer Research. 78: 4091-4091. DOI: 10.1158/1538-7445.Am2018-4091 |
0.607 |
|
| 2018 |
Wu K, Grbovic-Huezo O, Hartmann G, Jacks T, Tammela T. Abstract 1124: Wnt-producing niche cells support cancer stem-like cells in pancreatic ductal adenocarcinoma Tumor Biology. DOI: 10.1158/1538-7445.Am2018-1124 |
0.531 |
|
| 2017 |
Chen PY, Muzumdar MD, Dorans KJ, Robbins RA, Bhutkar A, Del Rosario AM, Mertins P, Qiao J, Schäfer C, Gertler FB, Carr SA, Jacks T. Adaptive and reversible resistance to Kras inhibition in pancreatic cancer cells. Cancer Research. PMID 29279356 DOI: 10.1158/0008-5472.Can-17-2129 |
0.591 |
|
| 2017 |
Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli MA, Sánchez-Rivera F, Park YK, Liang X, Eng G, Taylor MS, Azimi R, ... ... Jacks T, et al. Corrigendum: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Nature Biotechnology. 35: 1211. PMID 29220013 DOI: 10.1038/Nbt1217-1211A |
0.781 |
|
| 2017 |
Muzumdar MD, Chen PY, Dorans KJ, Chung KM, Bhutkar A, Hong E, Noll EM, Sprick MR, Trumpp A, Jacks T. Survival of pancreatic cancer cells lacking KRAS function. Nature Communications. 8: 1090. PMID 29061961 DOI: 10.1038/S41467-017-00942-5 |
0.593 |
|
| 2017 |
Romero R, Sayin VI, Davidson SM, Bauer MR, Singh SX, LeBoeuf SE, Karakousi TR, Ellis DC, Bhutkar A, Sánchez-Rivera FJ, Subbaraj L, Martinez B, Bronson RT, Prigge JR, Schmidt EE, ... ... Jacks T, et al. Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis. Nature Medicine. PMID 28967920 DOI: 10.1038/Nm.4407 |
0.828 |
|
| 2017 |
Li A, Jacks T. Driving Rel-iant Tregs toward an Identity Crisis. Immunity. 47: 391-393. PMID 28930651 DOI: 10.1016/J.Immuni.2017.08.014 |
0.555 |
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| 2017 |
Lee JH, Tammela T, Hofree M, Choi J, Marjanovic ND, Han S, Canner D, Wu K, Paschini M, Bhang DH, Jacks T, Regev A, Kim CF. Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6. Cell. 170: 1149-1163.e12. PMID 28886383 DOI: 10.1016/J.Cell.2017.07.028 |
0.807 |
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| 2017 |
Gocheva V, Naba A, Bhutkar A, Guardia T, Miller KM, Li CM, Dayton TL, Sanchez-Rivera FJ, Kim-Kiselak C, Jailkhani N, Winslow MM, Del Rosario A, Hynes RO, Jacks T. Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival. Proceedings of the National Academy of Sciences of the United States of America. PMID 28652369 DOI: 10.1073/Pnas.1707054114 |
0.823 |
|
| 2017 |
JnBaptiste CK, Gurtan AM, Thai KK, Lu V, Bhutkar A, Su MJ, Rotem A, Jacks T, Sharp PA. Corrigendum: Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1-3 family. Genes & Development. 31: 1066. PMID 28637695 DOI: 10.1101/gad.302513.117 |
0.404 |
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| 2017 |
Soto-Feliciano YM, Bartlebaugh JME, Liu Y, Sánchez-Rivera FJ, Bhutkar A, Weintraub AS, Buenrostro JD, Cheng CS, Regev A, Jacks TE, Young RA, Hemann MT. PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes. Genes & Development. PMID 28607179 DOI: 10.1101/Gad.295857.117 |
0.812 |
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| 2017 |
Tammela T, Sanchez-Rivera FJ, Cetinbas NM, Wu K, Joshi NS, Helenius K, Park Y, Azimi R, Kerper NR, Wesselhoeft RA, Gu X, Schmidt L, Cornwall-Brady M, Yilmaz ÖH, Xue W, ... ... Jacks T, et al. A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma. Nature. PMID 28489818 DOI: 10.1038/Nature22334 |
0.821 |
|
| 2017 |
Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli MA, Sánchez-Rivera F, Park YK, Liang X, Eng G, Taylor MS, Azimi R, ... ... Jacks T, et al. In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Nature Biotechnology. PMID 28459449 DOI: 10.1038/Nbt.3836 |
0.823 |
|
| 2017 |
JnBaptiste CK, Gurtan AM, Thai KK, Lu V, Bhutkar A, Su MJ, Rotem A, Jacks T, Sharp PA. Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1-3 family. Genes & Development. 31: 674-687. PMID 28446596 DOI: 10.1101/Gad.296301.117 |
0.482 |
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| 2017 |
Joshi N, Jacks T. Abstract A85: Investigating endogenous anti-tumor T cell responses in native tumor microenvironments Cancer Immunology Research. 5. DOI: 10.1158/2326-6074.Tumimm16-A85 |
0.59 |
|
| 2016 |
Dayton TL, Jacks T, Vander Heiden MG. PKM2, cancer metabolism, and the road ahead. Embo Reports. PMID 27856534 DOI: 10.15252/Embr.201643300 |
0.551 |
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| 2016 |
McFadden DG, Politi K, Bhutkar A, Chen FK, Song X, Pirun M, Santiago PM, Kim-Kiselak C, Platt JT, Lee E, Hodges E, Rosebrock AP, Bronson RT, Socci ND, Hannon GJ, ... Jacks T, et al. Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 27702896 DOI: 10.1073/Pnas.1613601113 |
0.8 |
|
| 2016 |
Mayers JR, Torrence ME, Danai LV, Papagiannakopoulos T, Davidson SM, Bauer MR, Lau AN, Ji BW, Dixit PD, Hosios AM, Muir A, Chin CR, Freinkman E, Jacks T, Wolpin BM, et al. Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers. Science (New York, N.Y.). 353: 1161-5. PMID 27609895 DOI: 10.1126/Science.Aaf5171 |
0.589 |
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| 2016 |
Singer DS, Jacks T, Jaffee E. A U.S. "Cancer Moonshot" to accelerate cancer research. Science (New York, N.Y.). 353: 1105-6. PMID 27605537 DOI: 10.1126/Science.Aai7862 |
0.499 |
|
| 2016 |
Muzumdar MD, Dorans KJ, Chung KM, Robbins R, Tammela T, Gocheva V, Li CM, Jacks T. Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers. Nature Communications. 7: 12685. PMID 27585860 DOI: 10.1038/Ncomms12685 |
0.6 |
|
| 2016 |
Papagiannakopoulos T, Bauer MR, Davidson SM, Heimann M, Subbaraj L, Bhutkar A, Bartlebaugh J, Vander Heiden MG, Jacks T. Circadian Rhythm Disruption Promotes Lung Tumorigenesis. Cell Metabolism. PMID 27476975 DOI: 10.1016/J.Cmet.2016.07.001 |
0.59 |
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| 2016 |
Sharp P, Jacks T, Hockfield S. BIOMEDICAL ENGINEERING. Capitalizing on convergence for health care. Science (New York, N.Y.). 352: 1522-3. PMID 27339972 DOI: 10.1126/Science.Aag2350 |
0.426 |
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| 2016 |
Masri S, Papagiannakopoulos T, Kinouchi K, Liu Y, Cervantes M, Baldi P, Jacks T, Sassone-Corsi P. Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis. Cell. 165: 896-909. PMID 27153497 DOI: 10.1016/J.Cell.2016.04.039 |
0.518 |
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| 2016 |
Dayton TL, Gocheva V, Miller KM, Israelsen WJ, Bhutkar A, Clish CB, Davidson SM, Luengo A, Bronson RT, Jacks T, Vander Heiden MG. Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma. Genes & Development. PMID 27125672 DOI: 10.1101/Gad.278549.116 |
0.519 |
|
| 2016 |
Akama-Garren EH, Joshi NS, Tammela T, Chang GP, Wagner BL, Lee DY, Rideout Iii WM, Papagiannakopoulos T, Xue W, Jacks T. A Modular Assembly Platform for Rapid Generation of DNA Constructs. Scientific Reports. 6: 16836. PMID 26887506 DOI: 10.1038/Srep16836 |
0.636 |
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| 2016 |
Davidson SM, Papagiannakopoulos T, Olenchock BA, Heyman JE, Keibler MA, Luengo A, Bauer MR, Jha AK, O'Brien JP, Pierce KA, Gui DY, Sullivan LB, Wasylenko TM, Subbaraj L, Chin CR, ... ... Jacks T, et al. Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer. Cell Metabolism. PMID 26853747 DOI: 10.1016/J.Cmet.2016.01.007 |
0.567 |
|
| 2016 |
Mayers JR, Torrence ME, Davidson SM, Papagiannakopoulos T, Lau AN, Jacks T, Heiden MGV. Abstract PR11: Tissue-of-origin dictates the metabolic fate of branched chain amino acids in mutant Kras-driven cancers Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Metca15-Pr11 |
0.581 |
|
| 2016 |
Bendor J, Zamudio J, Jacks T, Dimitrova N. Abstract PR02: The diverse roles of long noncoding RNAs in the p53 tumor suppressor pathway Cancer Research. 76. DOI: 10.1158/1538-7445.Nonrna15-Pr02 |
0.573 |
|
| 2016 |
Cabeceiras PK, Joshi NS, Jacks T. Abstract 659: Novel refinements for the autochthonous mouse model of cancer Cancer Research. 76: 659-659. DOI: 10.1158/1538-7445.Am2016-659 |
0.524 |
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| 2016 |
Fillmore CM, Xu C, Sánchez-Rivera FJ, Jacks T, Wong K, Kim CF. Using stem cell biology to design precision medicine for non-small cell lung cancer Journal of Thoracic Oncology. 11. DOI: 10.1016/J.Jtho.2015.12.006 |
0.792 |
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| 2015 |
Dimitrova N, Gocheva V, Bhutkar A, Resnick R, Jong RM, Miller KM, Bendor J, Jacks T. Stromal expression of miR-143/145 promotes neoangiogenesis in lung cancer development. Cancer Discovery. PMID 26586766 DOI: 10.1158/2159-8290.Cd-15-0854 |
0.493 |
|
| 2015 |
Robles-Oteiza C, Taylor S, Yates T, Cicchini M, Lauderback B, Cashman CR, Burds AA, Winslow MM, Jacks T, Feldser DM. Recombinase-based conditional and reversible gene regulation via XTR alleles. Nature Communications. 6: 8783. PMID 26537451 DOI: 10.1038/Ncomms9783 |
0.537 |
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| 2015 |
Mazur PK, Herner A, Mello SS, Wirth M, Hausmann S, Sánchez-Rivera FJ, Lofgren SM, Kuschma T, Hahn SA, Vangala D, Trajkovic-Arsic M, Gupta A, Heid I, Noël PB, Braren R, ... ... Jacks T, et al. Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. Nature Medicine. PMID 26390243 DOI: 10.1038/Nm.3952 |
0.797 |
|
| 2015 |
Li CM, Gocheva V, Oudin MJ, Bhutkar A, Wang SY, Date SR, Ng SR, Whittaker CA, Bronson RT, Snyder EL, Gertler FB, Jacks T. Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis. Genes & Development. 29: 1850-62. PMID 26341558 DOI: 10.1101/Gad.267393.115 |
0.59 |
|
| 2015 |
Joshi NS, Akama-Garren EH, Lu Y, Lee DY, Chang GP, Li A, DuPage M, Tammela T, Kerper NR, Farago AF, Robbins R, Crowley DM, Bronson RT, Jacks T. Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses. Immunity. 43: 579-90. PMID 26341400 DOI: 10.1016/J.Immuni.2015.08.006 |
0.584 |
|
| 2015 |
Sánchez-Rivera FJ, Jacks T. Applications of the CRISPR-Cas9 system in cancer biology. Nature Reviews. Cancer. 15: 387-95. PMID 26040603 DOI: 10.1038/Nrc3950 |
0.792 |
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| 2015 |
Li Y, Park AI, Mou H, Colpan C, Bizhanova A, Akama-Garren E, Joshi N, Hendrickson EA, Feldser D, Yin H, Anderson DG, Jacks T, Weng Z, Xue W. A versatile reporter system for CRISPR-mediated chromosomal rearrangements. Genome Biology. 16: 111. PMID 26018130 DOI: 10.1186/S13059-015-0680-7 |
0.582 |
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| 2015 |
Khan OF, Zaia EW, Jhunjhunwala S, Xue W, Cai W, Yun DS, Barnes CM, Dahlman JE, Dong Y, Pelet JM, Webber MJ, Tsosie JK, Jacks TE, Langer R, Anderson DG. Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature. Nano Letters. 15: 3008-16. PMID 25789998 DOI: 10.1021/Nl5048972 |
0.605 |
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| 2015 |
Faber AC, Farago AF, Costa C, Dastur A, Gomez-Caraballo M, Robbins R, Wagner BL, Rideout WM, Jakubik CT, Ham J, Edelman EJ, Ebi H, Yeo AT, Hata AN, Song Y, ... ... Jacks T, et al. Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 112: E1288-96. PMID 25737542 DOI: 10.1073/Pnas.1411848112 |
0.606 |
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| 2015 |
Gazdar AF, Savage TK, Johnson JE, Berns A, Sage J, Linnoila RI, MacPherson D, McFadden DG, Farago A, Jacks T, Travis WD, Brambilla E. The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 10: 553-64. PMID 25675280 DOI: 10.1097/Jto.0000000000000459 |
0.734 |
|
| 2015 |
Jacks T. Engineering the Cancer Genome Blood. 126. DOI: 10.1182/Blood.V126.23.Sci-19.Sci-19 |
0.626 |
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| 2014 |
Sánchez-Rivera FJ, Papagiannakopoulos T, Romero R, Tammela T, Bauer MR, Bhutkar A, Joshi NS, Subbaraj L, Bronson RT, Xue W, Jacks T. Rapid modelling of cooperating genetic events in cancer through somatic genome editing. Nature. 516: 428-31. PMID 25337879 DOI: 10.1038/Nature13906 |
0.814 |
|
| 2014 |
Xue W, Chen S, Yin H, Tammela T, Papagiannakopoulos T, Joshi NS, Cai W, Yang G, Bronson R, Crowley DG, Zhang F, Anderson DG, Sharp PA, Jacks T. CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature. 514: 380-4. PMID 25119044 DOI: 10.1038/Nature13589 |
0.695 |
|
| 2014 |
Xue W, Dahlman JE, Tammela T, Khan OF, Sood S, Dave A, Cai W, Chirino LM, Yang GR, Bronson R, Crowley DG, Sahay G, Schroeder A, Langer R, Anderson DG, ... Jacks T, et al. Small RNA combination therapy for lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 111: E3553-61. PMID 25114235 DOI: 10.1073/Pnas.1412686111 |
0.68 |
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| 2014 |
Shao DD, Xue W, Krall EB, Bhutkar A, Piccioni F, Wang X, Schinzel AC, Sood S, Rosenbluh J, Kim JW, Zwang Y, Roberts TM, Root DE, Jacks T, Hahn WC. KRAS and YAP1 converge to regulate EMT and tumor survival. Cell. 158: 171-84. PMID 24954536 DOI: 10.1016/J.Cell.2014.06.004 |
0.76 |
|
| 2014 |
Chiou SH, Kim-Kiselak C, Risca VI, Heimann MK, Chuang CH, Burds AA, Greenleaf WJ, Jacks TE, Feldser DM, Winslow MM. A conditional system to specifically link disruption of protein-coding function with reporter expression in mice. Cell Reports. 7: 2078-86. PMID 24931605 DOI: 10.1016/J.Celrep.2014.05.031 |
0.451 |
|
| 2014 |
Karsli-Uzunbas G, Guo JY, Price S, Teng X, Laddha SV, Khor S, Kalaany NY, Jacks T, Chan CS, Rabinowitz JD, White E. Autophagy is required for glucose homeostasis and lung tumor maintenance. Cancer Discovery. 4: 914-27. PMID 24875857 DOI: 10.1158/2159-8290.Cd-14-0363 |
0.601 |
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| 2014 |
Dimitrova N, Zamudio JR, Jong RM, Soukup D, Resnick R, Sarma K, Ward AJ, Raj A, Lee JT, Sharp PA, Jacks T. LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint. Molecular Cell. 54: 777-90. PMID 24857549 DOI: 10.1016/J.Molcel.2014.04.025 |
0.549 |
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| 2014 |
McFadden DG, Vernon A, Santiago PM, Martinez-McFaline R, Bhutkar A, Crowley DM, McMahon M, Sadow PM, Jacks T. p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer. Proceedings of the National Academy of Sciences of the United States of America. 111: E1600-9. PMID 24711431 DOI: 10.1073/Pnas.1404357111 |
0.515 |
|
| 2014 |
Gierut JJ, Jacks TE, Haigis KM. Whole-mount X-Gal staining of mouse tissues. Cold Spring Harbor Protocols. 2014: 417-9. PMID 24692489 DOI: 10.1101/Pdb.Prot073452 |
0.746 |
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| 2014 |
Gierut JJ, Jacks TE, Haigis KM. Strategies to achieve conditional gene mutation in mice. Cold Spring Harbor Protocols. 2014: 339-49. PMID 24692485 DOI: 10.1101/Pdb.Top069807 |
0.766 |
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| 2014 |
Yin H, Xue W, Chen S, Bogorad RL, Benedetti E, Grompe M, Koteliansky V, Sharp PA, Jacks T, Anderson DG. Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype. Nature Biotechnology. 32: 551-3. PMID 24681508 DOI: 10.1038/Nbt.2884 |
0.663 |
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| 2014 |
McFadden DG, Papagiannakopoulos T, Taylor-Weiner A, Stewart C, Carter SL, Cibulskis K, Bhutkar A, McKenna A, Dooley A, Vernon A, Sougnez C, Malstrom S, Heimann M, Park J, Chen F, ... ... Jacks T, et al. Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing. Cell. 156: 1298-311. PMID 24630729 DOI: 10.1016/J.Cell.2014.02.031 |
0.587 |
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| 2014 |
Gierut JJ, Jacks TE, Haigis KM. In vivo delivery of lenti-Cre or adeno-Cre into mice using intranasal instillation. Cold Spring Harbor Protocols. 2014: 307-9. PMID 24591689 DOI: 10.1101/Pdb.Prot073445 |
0.777 |
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| 2014 |
Gierut JJ, Jacks TE, Haigis KM. Producing and concentrating lenti-Cre for mouse infections. Cold Spring Harbor Protocols. 2014: 304-6. PMID 24591688 DOI: 10.1101/Pdb.Prot073437 |
0.733 |
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| 2014 |
Vanden Borre P, McFadden DG, Gunda V, Sadow PM, Varmeh S, Bernasconi M, Jacks T, Parangi S. The next generation of orthotopic thyroid cancer models: immunocompetent orthotopic mouse models of BRAF V600E-positive papillary and anaplastic thyroid carcinoma. Thyroid : Official Journal of the American Thyroid Association. 24: 705-14. PMID 24295207 DOI: 10.1089/Thy.2013.0483 |
0.529 |
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| 2014 |
Tammela T, Kerper N, Xue W, Joshi N, Katajisto P, Jacks T. Abstract 99: Wnt signaling promotes tumor propagation in a mouse model of lung adenocarcinoma Cancer Research. 74: 99-99. DOI: 10.1158/1538-7445.Am2014-99 |
0.711 |
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| 2014 |
Carter SL, Brastianos PK, McFadden DG, Papagiannakopoulos T, Taylor-Weiner A, Cibulskis K, Jacks T, Hahn W, Getz G. Abstract 3992: Modes of metastasis evolution in human and murine cancer revealed by whole exome sequencing Cancer Research. 74: 3992-3992. DOI: 10.1158/1538-7445.Am2014-3992 |
0.655 |
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| 2014 |
Sánchez-Rivera FJ, Ryan J, Soto-Feliciano YM, Feldser DM, Hemann MT, Letai A, Jacks T. Abstract 2961: The level of mitochondrial apoptotic priming determines cell fate upon p53 restoration Cancer Research. 74: 2961-2961. DOI: 10.1158/1538-7445.Am2014-2961 |
0.611 |
|
| 2014 |
Yin H, Xue W, Chen S, Bogorad RL, Benedetti E, Grompe M, Koteliansky V, Sharp PA, Jacks T, Anderson DG. Erratum: Corrigendum: Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype Nature Biotechnology. 32: 952-952. DOI: 10.1038/Nbt0914-952D |
0.638 |
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| 2013 |
Morandell S, Reinhardt HC, Cannell IG, Kim JS, Ruf DM, Mitra T, Couvillon AD, Jacks T, Yaffe MB. A Reversible Gene-Targeting Strategy Identifies Synthetic Lethal Interactions between MK2 and p53 in the DNA Damage Response InVivo Cell Reports. 5: 868-877. PMID 24239348 DOI: 10.1016/J.Celrep.2013.10.025 |
0.618 |
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| 2013 |
Israelsen WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW, Burga LN, Xie J, Jurczak MJ, DePinho RA, Clish CB, ... Jacks T, et al. PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell. 155: 397-409. PMID 24120138 DOI: 10.1016/J.Cell.2013.09.025 |
0.587 |
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| 2013 |
Li CM, Chen G, Dayton TL, Kim-Kiselak C, Hoersch S, Whittaker CA, Bronson RT, Beer DG, Winslow MM, Jacks T. Differential Tks5 isoform expression contributes to metastatic invasion of lung adenocarcinoma. Genes & Development. 27: 1557-67. PMID 23873940 DOI: 10.1101/Gad.222745.113 |
0.531 |
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| 2013 |
Guo JY, Karsli-Uzunbas G, Mathew R, Aisner SC, Kamphorst JJ, Strohecker AM, Chen G, Price S, Lu W, Teng X, Snyder E, Santanam U, Dipaola RS, Jacks T, Rabinowitz JD, et al. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes & Development. 27: 1447-61. PMID 23824538 DOI: 10.1101/Gad.219642.113 |
0.599 |
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| 2013 |
Xu J, Haigis KM, Firestone AJ, McNerney ME, Li Q, Davis E, Chen SC, Nakitandwe J, Downing J, Jacks T, Le Beau MM, Shannon K. Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation. Cancer Discovery. 3: 993-1001. PMID 23733505 DOI: 10.1158/2159-8290.Cd-13-0096 |
0.804 |
|
| 2013 |
Curry NL, Mino-Kenudson M, Oliver TG, Yilmaz OH, Yilmaz VO, Moon JY, Jacks T, Sabatini DM, Kalaany NY. Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction. Cancer Discovery. 3: 908-21. PMID 23719831 DOI: 10.1158/2159-8290.Cd-12-0507 |
0.584 |
|
| 2013 |
Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, ... ... Jacks T, et al. A physical sciences network characterization of non-tumorigenic and metastatic cells. Scientific Reports. 3: 1449. PMID 23618955 DOI: 10.1038/Srep01449 |
0.634 |
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| 2013 |
Byun S, Son S, Amodei D, Cermak N, Shaw J, Kang JH, Hecht VC, Winslow MM, Jacks T, Mallick P, Manalis SR. Characterizing deformability and surface friction of cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 7580-5. PMID 23610435 DOI: 10.1073/Pnas.1218806110 |
0.457 |
|
| 2013 |
Snyder EL, Watanabe H, Magendantz M, Hoersch S, Chen TA, Wang DG, Crowley D, Whittaker CA, Meyerson M, Kimura S, Jacks T. Nkx2-1 represses a latent gastric differentiation program in lung adenocarcinoma. Molecular Cell. 50: 185-99. PMID 23523371 DOI: 10.1016/J.Molcel.2013.02.018 |
0.646 |
|
| 2013 |
Joshi NS, Jacks T. Immunology. Guilty by association. Science (New York, N.Y.). 339: 1160-1. PMID 23471395 DOI: 10.1126/Science.1235528 |
0.53 |
|
| 2013 |
DuPage M, Jacks T. Genetically engineered mouse models of cancer reveal new insights about the antitumor immune response. Current Opinion in Immunology. 25: 192-9. PMID 23465466 DOI: 10.1016/J.Coi.2013.02.005 |
0.563 |
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| 2013 |
Watanabe H, Francis JM, Woo MS, Etemad B, Lin W, Fries DF, Peng S, Snyder EL, Tata PR, Izzo F, Schinzel AC, Cho J, Hammerman PS, Verhaak RG, Hahn WC, ... ... Jacks T, et al. Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target. Genes & Development. 27: 197-210. PMID 23322301 DOI: 10.1101/Gad.203208.112 |
0.676 |
|
| 2013 |
Li CM, Chen G, Dayton T, Kim-Kiselak C, Beer D, Winslow M, Jacks T. Abstract C22: Differential Tks5 isoform expression contributes to metastatic invasion of lung adenocarcinoma Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-C22 |
0.576 |
|
| 2013 |
Curry NL, Mino-Kenudson M, Oliver TG, Yilmaz OH, Yilmaz VO, Moon J, Jacks T, Sabatini DM, Kalaany NY. Abstract 4317: PTEN-null tumors cohabiting the same lung display differential Akt activation and sensitivity to dietary restriction. Cancer Research. 73: 4317-4317. DOI: 10.1158/1538-7445.Am2013-4317 |
0.612 |
|
| 2013 |
Watanabe H, Francis JM, Woo MS, Etemad B, Lin W, Fries DF, Peng S, Snyder EL, Tata PR, Schinzel AC, Cho J, Hammerman PS, Verhaak RG, Hahn WC, Rajagopal J, ... Jacks T, et al. Abstract 3127: Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target. Cancer Research. 73: 3127-3127. DOI: 10.1158/1538-7445.Am2013-3127 |
0.712 |
|
| 2013 |
McFadden DG, Papagiannakopoulos T, Cibulskis K, Stewart C, Carter S, Taylor-Weiner A, Bhutkar A, Sougnez C, Dooley A, Shefler E, Lander E, Gabriel S, Getz G, Jacks T. Abstract 1084: Comprehensive genomic analysis of murine small cell lung carcinoma uncovers recurrent Pten alterations that drive tumor progression and alter tumor genome evolution. Cancer Research. 73: 1084-1084. DOI: 10.1158/1538-7445.Am2013-1084 |
0.593 |
|
| 2012 |
Reticker-Flynn NE, Malta DF, Winslow MM, Lamar JM, Xu MJ, Underhill GH, Hynes RO, Jacks TE, Bhatia SN. A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis. Nature Communications. 3: 1122. PMID 23047680 DOI: 10.1038/Ncomms2128 |
0.433 |
|
| 2012 |
Ravi A, Gurtan AM, Kumar MS, Bhutkar A, Chin C, Lu V, Lees JA, Jacks T, Sharp PA. Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1. Cancer Cell. 21: 848-55. PMID 22698408 DOI: 10.1016/J.Ccr.2012.04.037 |
0.518 |
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| 2012 |
Farago AF, Snyder EL, Jacks T. SnapShot: Lung cancer models. Cell. 149: 246-246.e1. PMID 22464334 DOI: 10.1016/J.Cell.2012.03.015 |
0.55 |
|
| 2012 |
DuPage M, Mazumdar C, Schmidt LM, Cheung AF, Jacks T. Expression of tumour-specific antigens underlies cancer immunoediting. Nature. 482: 405-9. PMID 22318517 DOI: 10.1038/Nature10803 |
0.533 |
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| 2012 |
Itzkovitz S, Blat IC, Jacks T, Clevers H, van Oudenaarden A. Optimality in the development of intestinal crypts. Cell. 148: 608-19. PMID 22304925 DOI: 10.1016/J.Cell.2011.12.025 |
0.431 |
|
| 2012 |
Schroeder A, Heller DA, Winslow MM, Dahlman JE, Pratt GW, Langer R, Jacks T, Anderson DG. Treating metastatic cancer with nanotechnology. Nature Reviews. Cancer. 12: 39-50. PMID 22193407 DOI: 10.1038/Nrc3180 |
0.525 |
|
| 2012 |
Itzkovitz S, Lyubimova A, Blat IC, Maynard M, van Es J, Lees J, Jacks T, Clevers H, van Oudenaarden A. Single-molecule transcript counting of stem-cell markers in the mouse intestine. Nature Cell Biology. 14: 106-14. PMID 22119784 DOI: 10.1038/Ncb2384 |
0.516 |
|
| 2012 |
Dimitrova NM, Jacks T. Abstract PR2: Functional characterization of p53-regulated long intervening non-coding RNAs (lincRNAs Cancer Research. 72. DOI: 10.1158/1538-7445.Nonrna12-Pr2 |
0.577 |
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| 2012 |
Sánchez-Rivera FJ, Feldser DM, Doench J, Bhutkar A, Meacham CE, Root DE, Hemann MT, Jacks T. Abstract 2957: Uncovering tumor-specific components of the p53 pathway using mouse models and RNAi Cancer Research. 72: 2957-2957. DOI: 10.1158/1538-7445.Am2012-2957 |
0.631 |
|
| 2011 |
Xue W, Meylan E, Oliver TG, Feldser DM, Winslow MM, Bronson R, Jacks T. Response and resistance to NF-κB inhibitors in mouse models of lung adenocarcinoma. Cancer Discovery. 1: 236-47. PMID 21874163 DOI: 10.1158/2159-8290.Cd-11-0073 |
0.673 |
|
| 2011 |
Kumar MS, Narla A, Nonami A, Mullally A, Dimitrova N, Ball B, McAuley JR, Poveromo L, Kutok JL, Galili N, Raza A, Attar E, Gilliland DG, Jacks T, Ebert BL. Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q- syndrome. Blood. 118: 4666-73. PMID 21873545 DOI: 10.1182/Blood-2010-12-324715 |
0.476 |
|
| 2011 |
To MD, Quigley DA, Mao JH, Del Rosario R, Hsu J, Hodgson G, Jacks T, Balmain A. Progressive genomic instability in the FVB/Kras(LA2) mouse model of lung cancer. Molecular Cancer Research : McR. 9: 1339-45. PMID 21807965 DOI: 10.1158/1541-7786.Mcr-11-0219 |
0.583 |
|
| 2011 |
Dooley AL, Winslow MM, Chiang DY, Banerji S, Stransky N, Dayton TL, Snyder EL, Senna S, Whittaker CA, Bronson RT, Crowley D, Barretina J, Garraway L, Meyerson M, Jacks T. Nuclear factor I/B is an oncogene in small cell lung cancer. Genes & Development. 25: 1470-5. PMID 21764851 DOI: 10.1101/Gad.2046711 |
0.638 |
|
| 2011 |
Oliver TG, Meylan E, Chang GP, Xue W, Burke JR, Humpton TJ, Hubbard D, Bhutkar A, Jacks T. Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. Molecular Cell. 43: 57-71. PMID 21726810 DOI: 10.1016/J.Molcel.2011.06.012 |
0.658 |
|
| 2011 |
Shaw AT, Winslow MM, Magendantz M, Ouyang C, Dowdle J, Subramanian A, Lewis TA, Maglathin RL, Tolliday N, Jacks T. Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 108: 8773-8. PMID 21555567 DOI: 10.1073/Pnas.1105941108 |
0.502 |
|
| 2011 |
Young NP, Crowley D, Jacks T. Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis. Cancer Research. 71: 4040-7. PMID 21512139 DOI: 10.1158/0008-5472.CAN-10-4563 |
0.587 |
|
| 2011 |
Winslow MM, Dayton TL, Verhaak RG, Kim-Kiselak C, Snyder EL, Feldser DM, Hubbard DD, DuPage MJ, Whittaker CA, Hoersch S, Yoon S, Crowley D, Bronson RT, Chiang DY, Meyerson M, ... Jacks T, et al. Suppression of lung adenocarcinoma progression by Nkx2-1. Nature. 473: 101-4. PMID 21471965 DOI: 10.1038/Nature09881 |
0.686 |
|
| 2011 |
Cellurale C, Sabio G, Kennedy NJ, Das M, Barlow M, Sandy P, Jacks T, Davis RJ. Requirement of c-Jun NH(2)-terminal kinase for Ras-initiated tumor formation. Molecular and Cellular Biology. 31: 1565-76. PMID 21282468 DOI: 10.1128/Mcb.01122-10 |
0.6 |
|
| 2011 |
DuPage M, Cheung AF, Mazumdar C, Winslow MM, Bronson R, Schmidt LM, Crowley D, Chen J, Jacks T. Endogenous T cell responses to antigens expressed in lung adenocarcinomas delay malignant tumor progression. Cancer Cell. 19: 72-85. PMID 21251614 DOI: 10.1016/J.Ccr.2010.11.011 |
0.572 |
|
| 2011 |
Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, Akagi K, Wong JC, Braun BS, Wolff L, Jacks T, Shannon K. Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. Blood. 117: 2022-32. PMID 21163920 DOI: 10.1182/Blood-2010-04-280750 |
0.787 |
|
| 2011 |
Xue W, Meylan E, Oliver T, Jacks T. Abstract 1612: Investigating NF-κB pathway as a novel therapeutic target in preclinical lung cancer mouse models Cancer Research. 71: 1612-1612. DOI: 10.1158/1538-7445.Am2011-1612 |
0.716 |
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| 2010 |
Feldser DM, Kostova KK, Winslow MM, Taylor SE, Cashman C, Whittaker CA, Sanchez-Rivera FJ, Resnick R, Bronson R, Hemann MT, Jacks T. Stage-specific sensitivity to p53 restoration during lung cancer progression. Nature. 468: 572-5. PMID 21107428 DOI: 10.1038/Nature09535 |
0.828 |
|
| 2010 |
Doles J, Oliver TG, Cameron ER, Hsu G, Jacks T, Walker GC, Hemann MT. Suppression of Rev3, the catalytic subunit of Pol{zeta}, sensitizes drug-resistant lung tumors to chemotherapy. Proceedings of the National Academy of Sciences of the United States of America. 107: 20786-91. PMID 21068376 DOI: 10.1073/Pnas.1011409107 |
0.528 |
|
| 2010 |
Jacks T. Targeting cancer: an interview with Tyler Jacks. Interview by Kathy Weston. Disease Models & Mechanisms. 3: 672-5. PMID 20940315 DOI: 10.1242/dmm.006882 |
0.427 |
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| 2010 |
Huarte M, Guttman M, Feldser D, Garber M, Koziol MJ, Kenzelmann-Broz D, Khalil AM, Zuk O, Amit I, Rabani M, Attardi LD, Regev A, Lander ES, Jacks T, Rinn JL. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell. 142: 409-19. PMID 20673990 DOI: 10.1016/J.Cell.2010.06.040 |
0.767 |
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| 2010 |
Mazumdar J, Hickey MM, Pant DK, Durham AC, Sweet-Cordero A, Vachani A, Jacks T, Chodosh LA, Kissil JL, Simon MC, Keith B. HIF-2alpha deletion promotes Kras-driven lung tumor development. Proceedings of the National Academy of Sciences of the United States of America. 107: 14182-7. PMID 20660313 DOI: 10.1073/Pnas.1001296107 |
0.537 |
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| 2010 |
Young NP, Jacks T. Tissue-specific p19Arf regulation dictates the response to oncogenic K-ras. Proceedings of the National Academy of Sciences of the United States of America. 107: 10184-9. PMID 20479239 DOI: 10.1073/Pnas.1004796107 |
0.6 |
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| 2010 |
Lazzara MJ, Lane K, Chan R, Jasper PJ, Yaffe MB, Sorger PK, Jacks T, Neel BG, Lauffenburger DA. Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations. Cancer Research. 70: 3843-50. PMID 20406974 DOI: 10.1158/0008-5472.Can-09-3421 |
0.546 |
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| 2010 |
Oliver TG, Mercer KL, Sayles LC, Burke JR, Mendus D, Lovejoy KS, Cheng MH, Subramanian A, Mu D, Powers S, Crowley D, Bronson RT, Whittaker CA, Bhutkar A, Lippard SJ, ... ... Jacks T, et al. Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. Genes & Development. 24: 837-52. PMID 20395368 DOI: 10.1101/Gad.1897010 |
0.612 |
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| 2010 |
Wong KK, Jacks T, Dranoff G. NF-kappaB fans the flames of lung carcinogenesis. Cancer Prevention Research (Philadelphia, Pa.). 3: 403-5. PMID 20354166 DOI: 10.1158/1940-6207.Capr-10-0042 |
0.562 |
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| 2010 |
Kirsch DG, Grimm J, Guimaraes AR, Wojtkiewicz GR, Perez BA, Santiago PM, Anthony NK, Forbes T, Doppke K, Weissleder R, Jacks T. Imaging primary lung cancers in mice to study radiation biology. International Journal of Radiation Oncology, Biology, Physics. 76: 973-7. PMID 20206017 DOI: 10.1016/J.Ijrobp.2009.11.038 |
0.582 |
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| 2010 |
Zhou Y, Rideout WM, Zi T, Bressel A, Reddypalli S, Rancourt R, Woo JK, Horner JW, Chin L, Chiu MI, Bosenberg M, Jacks T, Clark SC, Depinho RA, Robinson MO, et al. Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas. Nature Biotechnology. 28: 71-8. PMID 20023657 DOI: 10.1038/Nbt.1595 |
0.6 |
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| 2010 |
Kirsch DG, Santiago PM, di Tomaso E, Sullivan JM, Hou WS, Dayton T, Jeffords LB, Sodha P, Mercer KL, Cohen R, Takeuchi O, Korsmeyer SJ, Bronson RT, Kim CF, Haigis KM, ... ... Jacks T, et al. p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science (New York, N.Y.). 327: 593-6. PMID 20019247 DOI: 10.1126/Science.1166202 |
0.799 |
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| 2010 |
Cheung AF, Carter AM, Kostova KK, Woodruff JF, Crowley D, Bronson RT, Haigis KM, Jacks T. Complete deletion of Apc results in severe polyposis in mice. Oncogene. 29: 1857-64. PMID 20010873 DOI: 10.1038/Onc.2009.457 |
0.795 |
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| 2010 |
DuPage M, Cheung AF, Mazumdar C, Winslow MM, Bronson RT, Crowley D, Jacks T. Abstract LB-330: Endogenous T cell responses to lung adenocarcinoma neoantigens delay malignant tumor progression Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-330 |
0.587 |
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| 2010 |
McFadden DG, Xuan Z, Rosebrock A, Politi K, Santiago P, Hodges E, Winslow M, Hiramatsu N, Pirun M, Crowley D, Bronson R, Socci N, Varmus H, Hannon G, Jacks T. Abstract LB-151: Targeted gene resequencing in a K-ras-dependent mouse model of metastatic lung adenocarcinoma Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-151 |
0.814 |
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| 2010 |
Dooley AL, Winslow MM, Chiang D, Banerji S, Whittaker C, Bronson R, Crowley D, Meyerson M, Jacks T. Abstract LB-146: Identification of copy number alterations in small cell lung cancer Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-146 |
0.688 |
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| 2009 |
Mito JK, Riedel RF, Dodd L, Lahat G, Lazar AJ, Dodd RD, Stangenberg L, Eward WC, Hornicek FJ, Yoon SS, Brigman BE, Jacks T, Lev D, Mukherjee S, Kirsch DG. Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma. Plos One. 4: e8075. PMID 19956606 DOI: 10.1371/Journal.Pone.0008075 |
0.527 |
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| 2009 |
Kumar MS, Pester RE, Chen CY, Lane K, Chin C, Lu J, Kirsch DG, Golub TR, Jacks T. Dicer1 functions as a haploinsufficient tumor suppressor. Genes & Development. 23: 2700-4. PMID 19903759 DOI: 10.1101/Gad.1848209 |
0.565 |
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| 2009 |
Gidekel Friedlander SY, Chu GC, Snyder EL, Girnius N, Dibelius G, Crowley D, Vasile E, DePinho RA, Jacks T. Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras. Cancer Cell. 16: 379-89. PMID 19878870 DOI: 10.1016/J.Ccr.2009.09.027 |
0.565 |
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| 2009 |
Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P, Meylan E, Scholl C, Fröhling S, Chan EM, Sos ML, Michel K, Mermel C, ... ... Jacks T, et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature. 462: 108-12. PMID 19847166 DOI: 10.1038/Nature08460 |
0.729 |
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| 2009 |
Meylan E, Dooley AL, Feldser DM, Shen L, Turk E, Ouyang C, Jacks T. Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Nature. 462: 104-7. PMID 19847165 DOI: 10.1038/Nature08462 |
0.572 |
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| 2009 |
Lin YL, Sengupta S, Gurdziel K, Bell GW, Jacks T, Flores ER. p63 and p73 transcriptionally regulate genes involved in DNA repair. Plos Genetics. 5: e1000680. PMID 19816568 DOI: 10.1371/Journal.Pgen.1000680 |
0.548 |
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| 2009 |
Vasudevan KM, Barbie DA, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, ... ... Jacks T, et al. AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell. 16: 21-32. PMID 19573809 DOI: 10.1016/J.Ccr.2009.04.012 |
0.671 |
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| 2009 |
DuPage M, Dooley AL, Jacks T. Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase. Nature Protocols. 4: 1064-72. PMID 19561589 DOI: 10.1038/Nprot.2009.95 |
0.609 |
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| 2009 |
Yoon SS, Stangenberg L, Lee YJ, Rothrock C, Dreyfuss JM, Baek KH, Waterman PR, Nielsen GP, Weissleder R, Mahmood U, Park PJ, Jacks T, Dodd RD, Fisher CJ, Ryeom S, et al. Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma. International Journal of Radiation Oncology, Biology, Physics. 74: 1207-16. PMID 19545786 DOI: 10.1016/J.Ijrobp.2009.02.052 |
0.465 |
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| 2009 |
Scholl C, Fröhling S, Dunn IF, Schinzel AC, Barbie DA, Kim SY, Silver SJ, Tamayo P, Wadlow RC, Ramaswamy S, Döhner K, Bullinger L, Sandy P, Boehm JS, Root DE, ... Jacks T, et al. Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. Cell. 137: 821-34. PMID 19490892 DOI: 10.1016/J.Cell.2009.03.017 |
0.685 |
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| 2009 |
Ventura A, Jacks T. MicroRNAs and cancer: short RNAs go a long way. Cell. 136: 586-91. PMID 19239879 DOI: 10.1016/J.Cell.2009.02.005 |
0.507 |
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| 2009 |
Guttman M, Amit I, Garber M, French C, Lin MF, Feldser D, Huarte M, Zuk O, Carey BW, Cassady JP, Cabili MN, Jaenisch R, Mikkelsen TS, Jacks T, Hacohen N, et al. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature. 458: 223-7. PMID 19182780 DOI: 10.1038/Nature07672 |
0.517 |
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| 2009 |
Kumar M, Narla A, Nonami A, Ball B, Chin C, Chen C, Kutok JL, Galili N, Raza A, Attar EC, GIlliland DG, Jacks T, Ebert BL. Coordinate Loss of a MicroRNA Mir 145 and a Protein-Coding Gene RPS14 Cooperate in the Pathogenesis of 5q- Syndrome. Blood. 114: 947-947. DOI: 10.1182/Blood.V114.22.947.947 |
0.492 |
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| 2009 |
Jacks T. Abstract IA-4: Studying tumor evolution in mouse models of cancer Cancer Research. 69. DOI: 10.1158/0008-5472.Fbcr09-Ia-4 |
0.601 |
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| 2008 |
Cheung AF, Dupage MJ, Dong HK, Chen J, Jacks T. Regulated expression of a tumor-associated antigen reveals multiple levels of T-cell tolerance in a mouse model of lung cancer. Cancer Research. 68: 9459-68. PMID 19010921 DOI: 10.1158/0008-5472.Can-08-2634 |
0.565 |
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| 2008 |
Godar S, Ince TA, Bell GW, Feldser D, Donaher JL, Bergh J, Liu A, Miu K, Watnick RS, Reinhardt F, McAllister SS, Jacks T, Weinberg RA. Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Cell. 134: 62-73. PMID 18614011 DOI: 10.1016/J.Cell.2008.06.006 |
0.702 |
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| 2008 |
Zhang Q, Menon R, Deutsch EW, Pitteri SJ, Faca VM, Wang H, Newcomb LF, Depinho RA, Bardeesy N, Dinulescu D, Hung KE, Kucherlapati R, Jacks T, Politi K, Aebersold R, et al. A mouse plasma peptide atlas as a resource for disease proteomics. Genome Biology. 9: R93. PMID 18522751 DOI: 10.1186/Gb-2008-9-6-R93 |
0.622 |
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| 2008 |
Coussens LM, Jacks T. Genetic and cellular mechanisms of oncogenesis. Current Opinion in Genetics & Development. 18: 1-2. PMID 18440220 DOI: 10.1016/J.Gde.2008.04.001 |
0.458 |
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| 2008 |
Nolen-Walston RD, Kim CF, Mazan MR, Ingenito EP, Gruntman AM, Tsai L, Boston RC, Woolfenden AE, Jacks T, Hoffman AM. Cellular kinetics and modeling of bronchioalveolar stem cell response during lung regeneration American Journal of Physiology-Lung Cellular and Molecular Physiology. 294. PMID 18375744 DOI: 10.1152/Ajplung.00298.2007 |
0.781 |
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| 2008 |
Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, Niwa-Kawakita M, Sweet-Cordero A, Sebolt-Leopold J, Shannon KM, Settleman J, Giovannini M, Jacks T. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nature Genetics. 40: 600-8. PMID 18372904 DOI: 10.1038/Ng.115 |
0.812 |
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| 2008 |
Ventura A, Young AG, Winslow MM, Lintault L, Meissner A, Erkeland SJ, Newman J, Bronson RT, Crowley D, Stone JR, Jaenisch R, Sharp PA, Jacks T. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell. 132: 875-86. PMID 18329372 DOI: 10.1016/J.Cell.2008.02.019 |
0.456 |
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| 2008 |
Kumar MS, Erkeland SJ, Pester RE, Chen CY, Ebert MS, Sharp PA, Jacks T. Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proceedings of the National Academy of Sciences of the United States of America. 105: 3903-8. PMID 18308936 DOI: 10.1073/Pnas.0712321105 |
0.607 |
|
| 2008 |
Meylan E, Dooley A, Turk E, Jacks T. 195 NF-κB signaling is essential in lung adenocarcinoma Cytokine. 43: 286-286. DOI: 10.1016/J.Cyto.2008.07.258 |
0.499 |
|
| 2007 |
Kissil JL, Walmsley MJ, Hanlon L, Haigis KM, Bender Kim CF, Sweet-Cordero A, Eckman MS, Tuveson DA, Capobianco AJ, Tybulewicz VL, Jacks T. Requirement for Rac1 in a K-ras induced lung cancer in the mouse. Cancer Research. 67: 8089-94. PMID 17804720 DOI: 10.1158/0008-5472.Can-07-2300 |
0.81 |
|
| 2007 |
Pandey J, Umphress SM, Kang Y, Angdisen J, Naumova A, Mercer KL, Jacks T, Jakowlew SB. Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- b1 haploinsufficiency. Carcinogenesis. 28: 2589-96. PMID 17690114 DOI: 10.1093/Carcin/Bgm136 |
0.553 |
|
| 2007 |
Kirsch DG, Dinulescu DM, Miller JB, Grimm J, Santiago PM, Young NP, Nielsen GP, Quade BJ, Chaber CJ, Schultz CP, Takeuchi O, Bronson RT, Crowley D, Korsmeyer SJ, Yoon SS, ... ... Jacks T, et al. A spatially and temporally restricted mouse model of soft tissue sarcoma. Nature Medicine. 13: 992-7. PMID 17676052 DOI: 10.1038/Nm1602 |
0.586 |
|
| 2007 |
Wijnhoven SWP, Speksnijder EN, Liu X, Zwart E, VanOostrom CTM, Beems RB, Hoogervorst EM, Schaap MM, Attardi LD, Jacks T, Van Steeg H, Jonkers J, De Vries A. Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage Cancer Research. 67: 4648-4656. PMID 17510390 DOI: 10.1158/0008-5472.Can-06-4681 |
0.796 |
|
| 2007 |
Kumar MS, Lu J, Mercer KL, Golub TR, Jacks T. Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nature Genetics. 39: 673-7. PMID 17401365 DOI: 10.1038/Ng2003 |
0.508 |
|
| 2007 |
Shaw AT, Meissner A, Dowdle JA, Crowley D, Magendantz M, Ouyang C, Parisi T, Rajagopal J, Blank LJ, Bronson RT, Stone JR, Tuveson DA, Jaenisch R, Jacks T. Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes & Development. 21: 694-707. PMID 17369402 DOI: 10.1101/Gad.1526207 |
0.752 |
|
| 2007 |
McLaughlin ME, Kruger GM, Slocum KL, Crowley D, Michaud NA, Huang J, Magendantz M, Jacks T. The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusion. Proceedings of the National Academy of Sciences of the United States of America. 104: 3261-6. PMID 17360635 DOI: 10.1073/Pnas.0700044104 |
0.529 |
|
| 2007 |
Zhang J, Liu Y, Beard C, Tuveson DA, Jaenisch R, Jacks TE, Lodish HF. Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways. Blood. 109: 5238-41. PMID 17317860 DOI: 10.1182/Blood-2006-09-047050 |
0.679 |
|
| 2007 |
Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R, Jacks T. Restoration of p53 function leads to tumour regression in vivo. Nature. 445: 661-5. PMID 17251932 DOI: 10.1038/Nature05541 |
0.764 |
|
| 2007 |
MacPherson D, Conkrite K, Tam M, Mukai S, Mu D, Jacks T. Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification. The Embo Journal. 26: 784-94. PMID 17235288 DOI: 10.1038/Sj.Emboj.7601515 |
0.589 |
|
| 2007 |
Keller JW, Haigis KM, Franklin JL, Whitehead RH, Jacks T, Coffey RJ. Oncogenic K-RAS subverts the antiapoptotic role of N-RAS and alters modulation of the N-RAS:gelsolin complex. Oncogene. 26: 3051-9. PMID 17130841 DOI: 10.1038/Sj.Onc.1210103 |
0.758 |
|
| 2007 |
Li Q, Haigis K, McDaniel A, Huang B, Miller M, Shieh A, Kogan S, Wolff L, Jacks T, Shannon K. Expressing N-RasG12D from the Endogenous Promoter Induces Myeloproliferative Disease (MPD) and Cooperates with Retroviral Insertional Mutagenesis (RIM) To Generate Acute Myeloid Leukemia (AML). Blood. 110: 1616-1616. DOI: 10.1182/Blood.V110.11.1616.1616 |
0.782 |
|
| 2006 |
Charest A, Wilker EW, McLaughlin ME, Lane K, Gowda R, Coven S, McMahon K, Kovach S, Feng Y, Yaffe MB, Jacks T, Housman D. ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Research. 66: 7473-81. PMID 16885344 DOI: 10.1158/0008-5472.Can-06-1193 |
0.571 |
|
| 2006 |
Kim CF, Jackson EL, Kirsch DG, Grimm J, Shaw AT, Lane K, Kissil J, Olive KP, Sweet-Cordero A, Weissleder R, Jacks T. Mouse models of human non-small-cell lung cancer: raising the bar. Cold Spring Harbor Symposia On Quantitative Biology. 70: 241-50. PMID 16869760 DOI: 10.1101/Sqb.2005.70.037 |
0.578 |
|
| 2006 |
To MD, Perez-Losada J, Mao JH, Hsu J, Jacks T, Balmain A. A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice. Nature Genetics. 38: 926-30. PMID 16823377 DOI: 10.1038/Ng1836 |
0.596 |
|
| 2006 |
Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K. Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo. Blood. 108: 2041-4. PMID 16720837 DOI: 10.1182/Blood-2006-01-013490 |
0.698 |
|
| 2006 |
Daikoku T, Tranguch S, Trofimova IN, Dinulescu DM, Jacks T, Nikitin AY, Connolly DC, Dey SK. Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer. Cancer Research. 66: 2527-31. PMID 16510568 DOI: 10.1158/0008-5472.Can-05-4063 |
0.574 |
|
| 2006 |
Tuveson DA, Zhu L, Gopinathan A, Willis NA, Kachatrian L, Grochow R, Pin CL, Mitin NY, Taparowsky EJ, Gimotty PA, Hruban RH, Jacks T, Konieczny SF. Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma. Cancer Research. 66: 242-7. PMID 16397237 DOI: 10.1158/0008-5472.Can-05-2305 |
0.731 |
|
| 2006 |
Sweet-Cordero A, Tseng GC, You H, Douglass M, Huey B, Albertson D, Jacks T. Comparison of gene expression and DNA copy number changes in a murine model of lung cancer. Genes, Chromosomes & Cancer. 45: 338-48. PMID 16323170 DOI: 10.1002/Gcc.20296 |
0.554 |
|
| 2006 |
Haigis K, Sage J, Glickman J, Shafer S, Jacks T. The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium. The Journal of Biological Chemistry. 281: 638-47. PMID 16258171 DOI: 10.1074/Jbc.M509053200 |
0.821 |
|
| 2006 |
Kirsch D, Santiago P, Haigis K, di Tomaso E, Takeuchi O, Korsmeyer S, Bronson R, Jain R, Jacks T. 2685 International Journal of Radiation Oncology*Biology*Physics. 66: S590. DOI: 10.1016/J.Ijrobp.2006.07.1100 |
0.743 |
|
| 2005 |
Jacks T. Modeling cancer in the mouse. Harvey Lectures. 101: 1-19. PMID 18030972 |
0.456 |
|
| 2005 |
Jacks T. The beginning of the end of frustration. Cold Spring Harbor Symposia On Quantitative Biology. 70: 525-528. PMID 16869791 DOI: 10.1101/Sqb.2005.70.053 |
0.516 |
|
| 2005 |
Jackson EL, Olive KP, Tuveson DA, Bronson R, Crowley D, Brown M, Jacks T. The differential effects of mutant p53 alleles on advanced murine lung cancer. Cancer Research. 65: 10280-8. PMID 16288016 DOI: 10.1158/0008-5472.Can-05-2193 |
0.772 |
|
| 2005 |
Chao RC, Pyzel U, Fridlyand J, Kuo YM, Teel L, Haaga J, Borowsky A, Horvai A, Kogan SC, Bonifas J, Huey B, Jacks TE, Albertson DG, Shannon KM. Therapy-induced malignant neoplasms in Nf1 mutant mice. Cancer Cell. 8: 337-48. PMID 16226708 DOI: 10.1016/J.Ccr.2005.08.011 |
0.524 |
|
| 2005 |
Grimm J, Kirsch DG, Windsor SD, Kim CF, Santiago PM, Ntziachristos V, Jacks T, Weissleder R. Use of gene expression profiling to direct in vivo molecular imaging of lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 102: 14404-9. PMID 16183744 DOI: 10.1073/Pnas.0503920102 |
0.799 |
|
| 2005 |
Wijnhoven SW, Zwart E, Speksnijder EN, Beems RB, Olive KP, Tuveson DA, Jonkers J, Schaap MM, van den Berg J, Jacks T, van Steeg H, de Vries A. Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development. Cancer Research. 65: 8166-73. PMID 16166291 DOI: 10.1158/0008-5472.Can-05-1650 |
0.757 |
|
| 2005 |
Sandy P, Ventura A, Jacks T. Mammalian RNAi: a practical guide. Biotechniques. 39: 215-24. PMID 16116795 DOI: 10.2144/05392Rv01 |
0.505 |
|
| 2005 |
Kuns R, Kissil JL, Newsham IF, Jacks T, Gutmann DH, Sherman LS. Protein 4.1B expression is induced in mammary epithelial cells during pregnancy and regulates their proliferation. Oncogene. 24: 6502-15. PMID 16007173 DOI: 10.1038/Sj.Onc.1208813 |
0.54 |
|
| 2005 |
Shaw AT, Kirsch DG, Jacks T. Future of Early Detection of Lung Cancer: The Role of Mouse Models Clinical Cancer Research. 11. PMID 16000603 DOI: 10.1158/1078-0432.Ccr-05-9005 |
0.55 |
|
| 2005 |
Kim CF, Jackson EL, Woolfenden AE, Lawrence S, Babar I, Vogel S, Crowley D, Bronson RT, Jacks T. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell. 121: 823-35. PMID 15960971 DOI: 10.1016/J.Cell.2005.03.032 |
0.8 |
|
| 2005 |
Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR, Golub TR. MicroRNA expression profiles classify human cancers. Nature. 435: 834-8. PMID 15944708 DOI: 10.1038/Nature03702 |
0.457 |
|
| 2005 |
Bono P, Cordero E, Johnson K, Borowsky M, Ramesh V, Jacks T, Hynes RO. Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin. Experimental Cell Research. 308: 177-87. PMID 15913605 DOI: 10.1016/J.Yexcr.2005.04.017 |
0.472 |
|
| 2005 |
Hoogervorst EM, Bruins W, Zwart E, Oostrom CTMv, Aardweg GJvd, Beems RB, Berg Jvd, Jacks T, Steeg Hv, Vries Ad. Lack of p53 Ser389 Phosphorylation Predisposes Mice to Develop 2-Acetylaminofluorene–Induced Bladder Tumors but not Ionizing Radiation–Induced Lymphomas Cancer Research. 65: 3610-3616. PMID 15867355 DOI: 10.1158/0008-5472.Can-04-4328 |
0.574 |
|
| 2005 |
Flores ER, Sengupta S, Miller JB, Newman JJ, Bronson R, Crowley D, Yang A, McKeon F, Jacks T. Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family. Cancer Cell. 7: 363-73. PMID 15837625 DOI: 10.1016/J.Ccr.2005.02.019 |
0.567 |
|
| 2005 |
Dinulescu DM, Ince TA, Quade BJ, Shafer SA, Crowley D, Jacks T. Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer Nature Medicine. 11: 63-70. PMID 15619626 DOI: 10.1038/Nm1173 |
0.565 |
|
| 2005 |
Sweet-Cordero A, Mukherjee S, Subramanian A, You H, Roix JJ, Ladd-Acosta C, Mesirov J, Golub TR, Jacks T. An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis. Nature Genetics. 37: 48-55. PMID 15608639 DOI: 10.1038/Ng1490 |
0.604 |
|
| 2005 |
Chen J, Gorman JR, Stewart V, Williams B, Jacks T, Alt FW. Generation of normal lymphocyte populations by Rb-deficient embryonic stem cells. Current Biology : Cb. 3: 405-13. PMID 15335707 DOI: 10.1016/0960-9822(93)90347-Q |
0.777 |
|
| 2005 |
Kirsch DG, Dinulescu DM, Santiago PM, Jacks T. A mouse model for soft tissue sarcoma. Journal of Clinical Oncology. 23: 9014-9014. DOI: 10.1200/Jco.2005.23.16_Suppl.9014 |
0.46 |
|
| 2005 |
Zhang J, Liu Y, Beard C, Jaenisch R, Jacks T, Lodish HF. The Role of K-ras Signaling in Erythropoiesis In Vivo. Blood. 106: 3136-3136. DOI: 10.1182/Blood.V106.11.3136.3136 |
0.53 |
|
| 2005 |
Kirsch D, Haigis K, Santiago P, Tukeshia O, Korsmeyer S, Jacks T. Using Mouse Genetics to Dissect the Cellular Target of Radiation in the GI Syndrome International Journal of Radiation Oncology*Biology*Physics. 63: S469. DOI: 10.1016/J.Ijrobp.2005.07.797 |
0.736 |
|
| 2004 |
Olive KP, Tuveson DA, Ruhe ZC, Yin B, Willis NA, Bronson RT, Crowley D, Jacks T. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell. 119: 847-60. PMID 15607980 DOI: 10.1016/J.Cell.2004.11.004 |
0.76 |
|
| 2004 |
Spike BT, Dirlam A, Dibling BC, Marvin J, Williams BO, Jacks T, Macleod KF. The Rb tumor suppressor is required for stress erythropoiesis. The Embo Journal. 23: 4319-29. PMID 15457215 DOI: 10.1038/Sj.Emboj.7600432 |
0.816 |
|
| 2004 |
Bruins W, Zwart E, Attardi LD, Iwakuma T, Hoogervorst EM, Beems RB, Miranda B, Van Oostrom CTM, Van Den Berg J, Van Den Aardweg GJ, Lozano G, Van Steeg H, Jacks T, De Vries A. Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389 Molecular and Cellular Biology. 24: 8884-8894. PMID 15456863 DOI: 10.1128/Mcb.24.20.8884-8894.2004 |
0.78 |
|
| 2004 |
Iwakuma T, Parant JM, Fasulo M, Zwart E, Jacks T, de Vries A, Lozano G. Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice. Oncogene. 23: 7644-50. PMID 15361844 DOI: 10.1038/Sj.Onc.1207793 |
0.577 |
|
| 2004 |
MacPherson D, Kim J, Kim T, Rhee BK, Van Oostrom CT, DiTullio RA, Venere M, Halazonetis TD, Bronson R, De Vries A, Fleming M, Jacks T. Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23. The Embo Journal. 23: 3689-99. PMID 15343266 DOI: 10.1038/Sj.Emboj.7600363 |
0.591 |
|
| 2004 |
Reilly KM, Tuskan RG, Christy E, Loisel DA, Ledger J, Bronson RT, Smith CD, Tsang S, Munroe DJ, Jacks T. Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects. Proceedings of the National Academy of Sciences of the United States of America. 101: 13008-13. PMID 15319471 DOI: 10.1073/Pnas.0401236101 |
0.581 |
|
| 2004 |
Ventura A, Meissner A, Dillon CP, McManus M, Sharp PA, Van Parijs L, Jaenisch R, Jacks T. Cre-lox-regulated conditional RNA interference from transgenes. Proceedings of the National Academy of Sciences of the United States of America. 101: 10380-5. PMID 15240889 DOI: 10.1073/Pnas.0403954101 |
0.501 |
|
| 2004 |
MacPherson D, Sage J, Kim T, Ho D, McLaughlin ME, Jacks T. Cell type-specific effects of Rb deletion in the murine retina. Genes & Development. 18: 1681-94. PMID 15231717 DOI: 10.1101/Gad.1203304 |
0.757 |
|
| 2004 |
Tuveson DA, Shaw AT, Willis NA, Silver DP, Jackson EL, Chang S, Mercer KL, Grochow R, Hock H, Crowley D, Hingorani SR, Zaks T, King C, Jacobetz MA, Wang L, ... ... Jacks T, et al. Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell. 5: 375-87. PMID 15093544 DOI: 10.1016/S1535-6108(04)00085-6 |
0.714 |
|
| 2004 |
Mayhew CN, Perkin LM, Zhang X, Sage J, Jacks T, Knudsen ES. Discrete signaling pathways participate in RB-dependent responses to chemotherapeutic agents. Oncogene. 23: 4107-20. PMID 15064736 DOI: 10.1038/Sj.Onc.1207503 |
0.761 |
|
| 2004 |
Nikitin AY, Alcaraz A, Anver MR, Bronson RT, Cardiff RD, Dixon D, Fraire AE, Gabrielson EW, Gunning WT, Haines DC, Kaufman MH, Linnoila RI, Maronpot RR, Rabson AS, Reddick RL, ... ... Jacks T, et al. Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium. Cancer Research. 64: 2307-16. PMID 15059877 DOI: 10.1158/0008-5472.Can-03-3376 |
0.544 |
|
| 2004 |
Chan IT, Kutok JL, Williams IR, Cohen S, Kelly L, Shigematsu H, Johnson L, Akashi K, Tuveson DA, Jacks T, Gilliland DG. Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease. The Journal of Clinical Investigation. 113: 528-38. PMID 14966562 DOI: 10.1172/Jci20476 |
0.806 |
|
| 2004 |
Attardi LD, De Vries A, Jacks T. Activation of the p53-dependent G1 checkpoint response in mouse embryo fibroblasts depends on the specific DNA damage inducer Oncogene. 23: 973-980. PMID 14749764 DOI: 10.1038/Sj.Onc.1207026 |
0.767 |
|
| 2004 |
Bosco EE, Mayhew CN, Hennigan RF, Sage J, Jacks T, Knudsen ES. RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult Nucleic Acids Research. 32: 25-34. PMID 14704340 DOI: 10.1093/Nar/Gkg919 |
0.732 |
|
| 2004 |
Braun BS, Tuveson DA, Kong N, Le DT, Kogan SC, Rozmus J, Le Beau MM, Jacks TE, Shannon KM. Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder. Proceedings of the National Academy of Sciences of the United States of America. 101: 597-602. PMID 14699048 DOI: 10.1073/Pnas.0307203101 |
0.701 |
|
| 2004 |
Braun BS, Gavin J, Tuveson DA, Jacks TE. In Vitro Analysis of Myeloid Proliferation Caused by Oncogenic Kras. Blood. 104: 795-795. DOI: 10.1182/Blood.V104.11.795.795 |
0.743 |
|
| 2004 |
Braun BS, van Ziffle J, Gavin J, Tuveson DA, Jacks T, Shannon K. Anemia and Ineffective Erythropoiesis Caused by Somatic RAS Mutation. Blood. 104: 3419-3419. DOI: 10.1182/Blood.V104.11.3419.3419 |
0.733 |
|
| 2004 |
Yu NA, Alcaraz A, Anver MR, Bronson RT, Cardiff RD, Dixon D, Fraire AE, Gabrielson E, Gunning WT, Haines DC, Kaufman MH, Linnoila RI, Maronpot RR, Rabson AS, Reddick RL, ... ... Jacks T, et al. Erratum: Classification of proliferative pulmonary lesions of the mouse: Recommendations of the mouse models of human cancers consortium (Cancer Research (April 1, 2004) 64 (2307-2316)) Cancer Research. 64. DOI: 10.1158/0008-5472.Can-64-10-Cor |
0.516 |
|
| 2004 |
Hingorani SR, Petricoin EF, Maitra A, Rajapakse V, King C, Jacobetz MA, Ross S, Conrads TP, Veenstra TD, Hitt BA, Kawaguchi Y, Johann D, Liotta LA, Crawford HC, Putt ME, ... Jacks T, et al. Erratum: Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse (Cancer Cell (4) (437-450)) Cancer Cell. 5. DOI: 10.1016/S1535-6108(03)00335-0 |
0.715 |
|
| 2003 |
Reczek EE, Flores ER, Tsay AS, Attardi LD, Jacks T. Multiple Response Elements and Differential p53 Binding Control Perp Expression during Apoptosis Molecular Cancer Research. 1: 1048-1057. PMID 14707288 |
0.77 |
|
| 2003 |
Hingorani SR, Petricoin EF, Maitra A, Rajapakse V, King C, Jacobetz MA, Ross S, Conrads TP, Veenstra TD, Hitt BA, Kawaguchi Y, Johann D, Liotta LA, Crawford HC, Putt ME, ... Jacks T, et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell. 4: 437-50. PMID 14706336 DOI: 10.1016/S1535-6108(03)00309-X |
0.732 |
|
| 2003 |
Balsitis SJ, Sage J, Duensing S, Münger K, Jacks T, Lambert PF. Recapitulation of the effects of the human papillomavirus type 16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRb-independent effects of E7 in vivo. Molecular and Cellular Biology. 23: 9094-103. PMID 14645521 DOI: 10.1128/Mcb.23.24.9094-9103.2003 |
0.736 |
|
| 2003 |
Ihrie RA, Reczek E, Horner JS, Khachatrian L, Sage J, Jacks T, Attardi LD. Perp Is a Mediator of p53-Dependent Apoptosis in Diverse Cell Types Current Biology. 13: 1985-1990. PMID 14614825 DOI: 10.1016/J.Cub.2003.10.055 |
0.816 |
|
| 2003 |
Kissil JL, Wilker EW, Johnson KC, Eckman MS, Yaffe MB, Jacks T. Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1. Molecular Cell. 12: 841-9. PMID 14580336 DOI: 10.1016/S1097-2765(03)00382-4 |
0.555 |
|
| 2003 |
Minna JD, Kurie JM, Jacks T. A big step in the study of small cell lung cancer. Cancer Cell. 4: 163-6. PMID 14522249 DOI: 10.1016/S1535-6108(03)00221-6 |
0.57 |
|
| 2003 |
Karlseder J, Kachatrian L, Takai H, Mercer K, Hingorani S, Jacks T, de Lange T. Targeted deletion reveals an essential function for the telomere length regulator Trf1. Molecular and Cellular Biology. 23: 6533-41. PMID 12944479 DOI: 10.1128/Mcb.23.18.6533-6541.2003 |
0.665 |
|
| 2003 |
McLaughlin ME, Robson CD, Kieran MW, Jacks T, Pomeroy SL, Cameron S. Marked regression of metastatic pilocytic astrocytoma during treatment with imatinib mesylate (STI-571, Gleevec): a case report and laboratory investigation. Journal of Pediatric Hematology/Oncology. 25: 644-8. PMID 12902920 DOI: 10.1097/00043426-200308000-00012 |
0.535 |
|
| 2003 |
Takahashi C, Bronson RT, Socolovsky M, Contreras B, Lee KY, Jacks T, Noda M, Kucherlapati R, Ewen ME. Rb and N-ras function together to control differentiation in the mouse. Molecular and Cellular Biology. 23: 5256-68. PMID 12861012 DOI: 10.1128/Mcb.23.15.5256-5268.2003 |
0.522 |
|
| 2003 |
Sage J, Miller AL, Pérez-Mancera PA, Wysocki JM, Jacks T. Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature. 424: 223-8. PMID 12853964 DOI: 10.1038/Nature01764 |
0.784 |
|
| 2003 |
McLaughlin ME, Jacks T. Neurofibromatosis type 1. Methods in Molecular Biology (Clifton, N.J.). 222: 223-37. PMID 12710690 DOI: 10.1385/1-59259-328-3:223 |
0.437 |
|
| 2003 |
Cichowski K, Santiago S, Jardim M, Johnson BW, Jacks T. Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor. Genes & Development. 17: 449-54. PMID 12600938 DOI: 10.1101/Gad.1054703 |
0.803 |
|
| 2003 |
McLaughlin ME, Jacks T. Progesterone receptor expression in neurofibromas. Cancer Research. 63: 752-5. PMID 12591720 |
0.457 |
|
| 2003 |
MacPherson D, Sage J, Crowley D, Trumpp A, Bronson RT, Jacks T. Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system Molecular and Cellular Biology. 23: 1044-1053. PMID 12529408 DOI: 10.1128/Mcb.23.3.1044-1053.2003 |
0.748 |
|
| 2002 |
Jacks T, Weinberg RA. Taking the study of cancer cell survival to a new dimension. Cell. 111: 923-5. PMID 12507419 DOI: 10.1016/S0092-8674(02)01229-1 |
0.712 |
|
| 2002 |
Tsai KY, MacPherson D, Rubinson DA, Nikitin AY, Bronson R, Mercer KL, Crowley D, Jacks T. ARF mutation accelerates pituitary tumor development in Rb+/- mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 16865-70. PMID 12486224 DOI: 10.1073/Pnas.262499599 |
0.577 |
|
| 2002 |
Lee HY, Suh YA, Lee JI, Hassan KA, Mao L, Force T, Gilbert BE, Jacks T, Kurie JM. Inhibition of oncogenic K-ras signaling by aerosolized gene delivery in a mouse model of human lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 2970-5. PMID 12231543 |
0.518 |
|
| 2002 |
Johnson KC, Kissil JL, Fry JL, Jacks T. Cellular transformation by a FERM domain mutant of the Nf2 tumor suppressor gene. Oncogene. 21: 5990-7. PMID 12203111 DOI: 10.1038/Sj.Onc.1205693 |
0.585 |
|
| 2002 |
McLaughlin ME, Jacks T. Thinking beyond the tumor cell: Nf1 haploinsufficiency in the tumor environment. Cancer Cell. 1: 408-10. PMID 12124168 DOI: 10.1016/S1535-6108(02)00078-8 |
0.559 |
|
| 2002 |
Klappacher GW, Lunyak VV, Sykes DB, Sawka-Verhelle D, Sage J, Brard G, Ngo SD, Gangadharan D, Jacks T, Kamps MP, Rose DW, Rosenfeld MG, Glass CK. An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. Cell. 109: 169-80. PMID 12007404 DOI: 10.1016/S0092-8674(02)00714-6 |
0.749 |
|
| 2002 |
Yang H, Williams BO, Hinds PW, Shih TS, Jacks T, Bronson RT, Livingston DM. Tumor suppression by a severely truncated species of retinoblastoma protein Molecular and Cellular Biology. 22: 3103-3110. PMID 11940667 DOI: 10.1128/Mcb.22.9.3103-3110.2002 |
0.781 |
|
| 2002 |
Flores ER, Tsai KY, Crowley D, Sengupta S, Yang A, McKeon F, Jacks T. p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature. 416: 560-4. PMID 11932750 DOI: 10.1038/416560A |
0.548 |
|
| 2002 |
de Vries A, Flores ER, Miranda B, Hsieh HM, van Oostrom CT, Sage J, Jacks T. Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function. Proceedings of the National Academy of Sciences of the United States of America. 99: 2948-53. PMID 11867759 DOI: 10.1073/Pnas.052713099 |
0.786 |
|
| 2002 |
Kim TJ, Cariappa A, Iacomini J, Tang M, Shih S, Bernards A, Jacks T, Pillai S. Defective proliferative responses in B lymphocytes and thymocytes that lack neurofibromin Molecular Immunology. 38: 701-708. PMID 11858825 DOI: 10.1016/S0161-5890(01)00101-8 |
0.776 |
|
| 2002 |
Van Dyke T, Jacks T. Cancer modeling in the modern era: progress and challenges. Cell. 108: 135-44. PMID 11832204 DOI: 10.1016/S0092-8674(02)00621-9 |
0.526 |
|
| 2002 |
Tsai KY, MacPherson D, Rubinson DA, Crowley D, Jacks T. ARF is not required for apoptosis in Rb mutant mouse embryos. Current Biology : Cb. 12: 159-63. PMID 11818069 DOI: 10.1016/S0960-9822(01)00659-5 |
0.587 |
|
| 2002 |
Costa RM, Federov NB, Kogan JH, Murphy GG, Stern J, Ohno M, Kucherlapati R, Jacks T, Silva AJ. Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature. 415: 526-30. PMID 11793011 DOI: 10.1038/Nature711 |
0.507 |
|
| 2002 |
Tuveson DA, Jacks T. Technologically advanced cancer modeling in mice. Current Opinion in Genetics & Development. 12: 105-10. PMID 11790563 DOI: 10.1016/S0959-437X(01)00272-6 |
0.74 |
|
| 2002 |
Kissil JL, Johnson KC, Eckman MS, Jacks T. Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization. The Journal of Biological Chemistry. 277: 10394-9. PMID 11782491 DOI: 10.1074/Jbc.M200083200 |
0.514 |
|
| 2001 |
Jackson EL, Willis N, Mercer K, Bronson RT, Crowley D, Montoya R, Jacks T, Tuveson DA. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes & Development. 15: 3243-8. PMID 11751630 DOI: 10.1101/Gad.943001 |
0.753 |
|
| 2001 |
Shaw RJ, Paez JG, Curto M, Yaktine A, Pruitt WM, Saotome I, O'Bryan JP, Gupta V, Ratner N, Der CJ, Jacks T, McClatchey AI. The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Developmental Cell. 1: 63-72. PMID 11703924 DOI: 10.1016/S1534-5807(01)00009-0 |
0.792 |
|
| 2001 |
Geng Y, Yu Q, Whoriskey W, Dick F, Tsai KY, Ford HL, Biswas DK, Pardee AB, Amati B, Jacks T, Richardson A, Dyson N, Sicinski P. Expression of cyclins E1 and E2 during mouse development and in neoplasia. Proceedings of the National Academy of Sciences of the United States of America. 98: 13138-43. PMID 11687642 DOI: 10.1073/Pnas.231487798 |
0.507 |
|
| 2001 |
Zhang Z, Wang Y, Vikis HG, Johnson L, Liu G, Li J, Anderson MW, Sills RC, Hong HL, Devereux TR, Jacks T, Guan KL, You M. Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nature Genetics. 29: 25-33. PMID 11528387 DOI: 10.1038/Ng721 |
0.83 |
|
| 2001 |
Tuveson DA, Willis NA, Jacks T, Griffin JD, Singer S, Fletcher CD, Fletcher JA, Demetri GD. STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications. Oncogene. 20: 5054-8. PMID 11526490 DOI: 10.1038/Sj.Onc.1204704 |
0.734 |
|
| 2001 |
Lipinski MM, Macleod KF, Williams BO, Mullaney TL, Crowley D, Jacks T. Cell-autonomous and non-cell-autonomous functions of the Rb tumor suppressor in developing central nervous system Embo Journal. 20: 3402-3413. PMID 11432828 DOI: 10.1093/Emboj/20.13.3402 |
0.819 |
|
| 2001 |
Reilly KM, Jacks T. Genetically engineered mouse models of astrocytoma: GEMs in the rough? Seminars in Cancer Biology. 11: 177-91. PMID 11407943 DOI: 10.1006/Scbi.2000.0375 |
0.549 |
|
| 2001 |
DePinho RA, Jacks T. Introduction. The laboratory mouse in cancer research. Seminars in Cancer Biology. 11: 175-6. PMID 11407942 DOI: 10.1006/Scbi.2000.0369 |
0.5 |
|
| 2001 |
Johnson L, Mercer K, Greenbaum D, Bronson RT, Crowley D, Tuveson DA, Jacks T. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature. 410: 1111-6. PMID 11323676 DOI: 10.1038/35074129 |
0.809 |
|
| 2001 |
Cichowski K, Jacks T. NF1 tumor suppressor gene function: narrowing the GAP. Cell. 104: 593-604. PMID 11239415 DOI: 10.1016/S0092-8674(01)00245-8 |
0.796 |
|
| 2001 |
Zhou C, Guo L, Morriello G, Pasternak A, Pan Y, Rohrer SP, Birzin ET, Huskey SE, Jacks T, Schleim KD, Cheng K, Schaeffer JM, Patchett AA, Yang L. Nipecotic and iso-nipecotic amides as potent and selective somatostatin subtype-2 receptor agonists. Bioorganic & Medicinal Chemistry Letters. 11: 415-7. PMID 11212124 DOI: 10.1016/S0960-894X(00)00687-9 |
0.344 |
|
| 2001 |
Boyd SD, Flores ER, Jacks T. Targets of the p53-related transcription factors Nature Genetics. 27: 45-45. DOI: 10.1038/87018 |
0.485 |
|
| 2000 |
Sage J, Mulligan GJ, Attardi LD, Miller A, Chen S, Williams B, Theodorou E, Jacks T. Targeted disruption of the three Rb-related genes leads to loss of G1 control and immortalization Genes and Development. 14: 3037-3050. PMID 11114892 DOI: 10.1101/Gad.843200 |
0.813 |
|
| 2000 |
Irwin M, Marin MC, Phillips AC, Seelan RS, Smith DI, Liu W, Flores ER, Tsai KY, Jacks T, Vousden KH, Kaelin WG. Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature. 407: 645-8. PMID 11034215 DOI: 10.1038/35036614 |
0.549 |
|
| 2000 |
Lim DJ, Rubenstein AE, Evans DG, Jacks T, Seizinger BG, Baser ME, Beebe D, Brackmann DE, Chiocca EA, Fehon RG, Giovannini M, Glazer R, Gusella JF, Gutmann DH, Korf B, et al. Advances in neurofibromatosis 2 (NF2): a workshop report. Journal of Neurogenetics. 14: 63-106. PMID 10992163 DOI: 10.3109/01677060009083477 |
0.444 |
|
| 2000 |
Boyd SD, Tsai KY, Jacks T. An intact HDM2 RING-finger domain is required for nuclear exclusion of p53. Nature Cell Biology. 2: 563-8. PMID 10980695 DOI: 10.1038/35023500 |
0.524 |
|
| 2000 |
Reilly KM, Loisel DA, Bronson RT, McLaughlin ME, Jacks T. Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nature Genetics. 26: 109-13. PMID 10973261 DOI: 10.1038/79075 |
0.56 |
|
| 2000 |
Zhang Y, Griffith EC, Sage J, Jacks T, Liu JO. Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1. Proceedings of the National Academy of Sciences of the United States of America. 97: 6427-32. PMID 10841547 DOI: 10.1073/Pnas.97.12.6427 |
0.766 |
|
| 2000 |
Attardi LD, Reczek EE, Cosmas C, Demicco EG, McCurrach ME, Lowe SW, Jacks T. PERP, an apoptosis-associated target of p53, in a novel member of the PMP-22/gas3 family Genes and Development. 14: 704-718. PMID 10733530 DOI: 10.1101/Gad.14.6.704 |
0.817 |
|
| 2000 |
Birnbaum RA, O'Marcaigh A, Wardak Z, Zhang YY, Dranoff G, Jacks T, Clapp DW, Shannon KM. Nf1 and Gmcsf interact in myeloid leukemogenesis. Molecular Cell. 5: 189-95. PMID 10678181 DOI: 10.1016/S1097-2765(00)80415-3 |
0.536 |
|
| 2000 |
Lipinski MM, Jacks T. The retinoblastoma gene family in differentiation and development. Oncogene. 18: 7873-82. PMID 10630640 DOI: 10.1038/Sj.Onc.1203244 |
0.582 |
|
| 1999 |
Deshaies RJ, Jacks T. Cell multiplication. Peering in and peering out: regulation of and by the cell cycle. Current Opinion in Cell Biology. 11: 705-7. PMID 10681127 DOI: 10.1016/S0955-0674(99)00040-X |
0.514 |
|
| 1999 |
Cichowski K, Shih TS, Schmitt E, Santiago S, Reilly K, McLaughlin ME, Bronson RT, Jacks T. Mouse models of tumor development in neurofibromatosis type 1. Science (New York, N.Y.). 286: 2172-6. PMID 10591652 DOI: 10.1126/Science.286.5447.2172 |
0.824 |
|
| 1999 |
DePinho RA, Jacks T. A bumper crop of cancer genes. Nature Genetics. 23: 253-4. PMID 10545932 DOI: 10.1038/15423 |
0.518 |
|
| 1999 |
Tuveson DA, Jacks T. Modeling human lung cancer in mice: similarities and shortcomings. Oncogene. 18: 5318-24. PMID 10498884 DOI: 10.1038/Sj.Onc.1203107 |
0.762 |
|
| 1999 |
De Lange T, Jacks T. For better or worse? Telomerase inhibition and cancer Cell. 98: 273-275. PMID 10458601 DOI: 10.1016/S0092-8674(00)81955-8 |
0.716 |
|
| 1999 |
Yang L, Morriello G, Leung K, Jacks T, Cheng K, Schleim KD, Smith R, Patchett AA. Thiazole-derived potent, highly bioavailable short duration growth hormone secretagogues. Bioorganic & Medicinal Chemistry Letters. 9: 1761-6. PMID 10406638 DOI: 10.1016/S0960-894X(99)00286-3 |
0.379 |
|
| 1999 |
Macleod KF, Jacks T. Insights into cancer from transgenic mouse models. The Journal of Pathology. 187: 43-60. PMID 10341706 DOI: 10.1002/(Sici)1096-9896(199901)187:1<43::Aid-Path246>3.0.Co;2-P |
0.809 |
|
| 1999 |
Pasternak A, Pan Y, Marino D, Sanderson PE, Mosley R, Rohrer SP, Birzin ET, Huskey SE, Jacks T, Schleim KD, Cheng K, Schaeffer JM, Patchett AA, Yang L. Potent, orally bioavailable somatostatin agonists: good absorption achieved by urea backbone cyclization. Bioorganic & Medicinal Chemistry Letters. 9: 491-6. PMID 10091708 DOI: 10.1016/S0960-894X(99)00016-5 |
0.339 |
|
| 1999 |
Attardi LD, Jacks T. The role of p53 in tumour suppression: Lessons from mouse models Cellular and Molecular Life Sciences. 55: 48-63. PMID 10065151 DOI: 10.1007/S000180050269 |
0.782 |
|
| 1999 |
Brugarolas J, Moberg K, Boyd SD, Taya Y, Jacks T, Lees JA. Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation. Proceedings of the National Academy of Sciences of the United States of America. 96: 1002-7. PMID 9927683 DOI: 10.1073/Pnas.96.3.1002 |
0.758 |
|
| 1999 |
Jacks T. Tumor Suppressor Gene Mutations in Mice Experimental Animals. 15: 1-2. DOI: 10.1538/Expanim1992.15.1 |
0.57 |
|
| 1999 |
Mahgoub N, Taylor BR, Gratiot M, Kohl NE, Gibbs JB, Jacks T, Shannon KM. In Vitro and In Vivo Effects of a Farnesyltransferase Inhibitor onNf1-Deficient Hematopoietic Cells Blood. 94: 2469-2476. DOI: 10.1182/Blood.V94.7.2469.419A01_2469_2476 |
0.545 |
|
| 1999 |
Mahgoub N, Taylor BR, Beau MML, Gratiot M, Carlson KM, Atwater SK, Jacks T, Shannon KM. Myeloid Malignancies Induced by Alkylating Agents in Nf1 Mice Blood. 93: 3617-3623. DOI: 10.1182/Blood.V93.11.3617 |
0.538 |
|
| 1999 |
DePinho RA, Jacks T. Guest Editors Oncogene. 18: 5247-5247. DOI: 10.1038/sj.onc.1203109 |
0.316 |
|
| 1999 |
DePinho RA, Jacks T. Introductory comments Oncogene. 18: 5248-5248. DOI: 10.1038/sj.onc.1203108 |
0.322 |
|
| 1998 |
Yang L, Morriello G, Prendergast K, Cheng K, Jacks T, Chan WW, Schleim KD, Smith RG, Patchett AA. Potent 3-spiropiperidine growth hormone secretagogues. Bioorganic & Medicinal Chemistry Letters. 8: 107-12. PMID 9925440 DOI: 10.1016/S0960-894X(97)10199-8 |
0.363 |
|
| 1998 |
Tsai KY, Hu Y, Macleod KF, Crowley D, Yamasaki L, Jacks T. Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Molecular Cell. 2: 293-304. PMID 9774968 DOI: 10.1016/S1097-2765(00)80274-9 |
0.811 |
|
| 1998 |
McClatchey AI, Jacks T. Tumor suppressor mutations in mice: the next generation. Current Opinion in Genetics & Development. 8: 304-10. PMID 9690995 DOI: 10.1016/S0959-437X(98)80086-5 |
0.582 |
|
| 1998 |
Yang L, Morriello G, Patchett AA, Leung K, Jacks T, Cheng K, Schleim KD, Feeney W, Chan WW, Chiu SH, Smith RG. 1-[2(R)-(2-amino-2-methylpropionylamino)-3-(1H-indol-3-yl)propionyl]- 3-benzylpiperidine-3(S)-carboxylic acid ethyl ester (L-163,540): a potent, orally bioavailable, and short-duration growth hormone secretagogue. Journal of Medicinal Chemistry. 41: 2439-41. PMID 9651148 DOI: 10.1021/jm9800191 |
0.341 |
|
| 1998 |
Mulligan G, Jacks T. The retinoblastoma gene family: cousins with overlapping interests. Trends in Genetics : Tig. 14: 223-9. PMID 9635405 DOI: 10.1016/S0168-9525(98)01470-X |
0.807 |
|
| 1998 |
Xu Y, Yang EM, Brugarolas J, Jacks T, Baltimore D. Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/- mice. Molecular and Cellular Biology. 18: 4385-90. PMID 9632822 DOI: 10.1128/Mcb.18.7.4385 |
0.757 |
|
| 1998 |
Jacks T, Weinberg RA. The expanding role of cell cycle regulators Science. 280: 1035-1036. PMID 9616080 DOI: 10.1126/Science.280.5366.1035 |
0.683 |
|
| 1998 |
Zhang YY, Vik TA, Ryder JW, Srour EF, Jacks T, Shannon K, Clapp DW. Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines Journal of Experimental Medicine. 187: 1893-1902. PMID 9607929 DOI: 10.1084/Jem.187.11.1893 |
0.548 |
|
| 1998 |
Zamble DB, Jacks T, Lippard SJ. p53-Dependent and -independent responses to cisplatin in mouse testicular teratocarcinoma cells Proceedings of the National Academy of Sciences of the United States of America. 95: 6163-6168. PMID 9600935 DOI: 10.1073/Pnas.95.11.6163 |
0.592 |
|
| 1998 |
McClatchey AI, Saotome I, Mercer K, Crowley D, Gusella JF, Bronson RT, Jacks T. Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. Genes & Development. 12: 1121-33. PMID 9553042 DOI: 10.1101/Gad.12.8.1121 |
0.586 |
|
| 1998 |
Brugarolas J, Bronson RT, Jacks T. p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells Journal of Cell Biology. 141: 503-514. PMID 9548727 DOI: 10.1083/Jcb.141.2.503 |
0.774 |
|
| 1998 |
Yamasaki L, Bronson R, Williams BO, Dyson NJ, Harlow E, Jacks T. Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice. Nature Genetics. 18: 360-4. PMID 9537419 DOI: 10.1038/Ng0498-360 |
0.762 |
|
| 1998 |
Shaw RJ, McClatchey AI, Jacks T. Regulation of the neurofibromatosis type 2 tumor suppressor protein, merlin, by adhesion and growth arrest stimuli. The Journal of Biological Chemistry. 273: 7757-64. PMID 9516485 DOI: 10.1074/Jbc.273.13.7757 |
0.784 |
|
| 1998 |
Shaw RJ, Henry M, Solomon F, Jacks T. RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts. Molecular Biology of the Cell. 9: 403-19. PMID 9450964 DOI: 10.1091/Mbc.9.2.403 |
0.742 |
|
| 1998 |
Lanni JS, Jacks T. Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Molecular and Cellular Biology. 18: 1055-64. PMID 9448003 DOI: 10.1128/Mcb.18.2.1055 |
0.559 |
|
| 1998 |
Mulligan GJ, Wong J, Jacks T. p130 is dispensable in peripheral T lymphocytes: evidence for functional compensation by p107 and pRB. Molecular and Cellular Biology. 18: 206-20. PMID 9418868 DOI: 10.1128/Mcb.18.1.206 |
0.552 |
|
| 1997 |
Johnson L, Greenbaum D, Cichowski K, Mercer K, Murphy E, Schmitt E, Bronson RT, Umanoff H, Edelmann W, Kucherlapati R, Jacks T. K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes & Development. 11: 2468-81. PMID 9334313 DOI: 10.1101/Gad.11.19.2468 |
0.792 |
|
| 1997 |
Lanni JS, Lowe SW, Licitra EJ, Liu JO, Jacks T. p53-independent apoptosis induced by paclitaxel through an indirect mechanism Proceedings of the National Academy of Sciences of the United States of America. 94: 9679-9683. PMID 9275183 DOI: 10.1073/Pnas.94.18.9679 |
0.731 |
|
| 1997 |
Jones JM, Attardi L, Godley LA, Laucirica R, Medina D, Jacks T, Varmus HE, Donehower LA. Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 8: 829-38. PMID 9269892 |
0.821 |
|
| 1997 |
Montes de Oca Luna R, Amelse LL, Chavez-Reyes A, Evans SC, Brugarolas J, Jacks T, Lozano G. Deletion of p21 cannot substitute for p53 loss in rescue of mdm2 null lethality. Nature Genetics. 16: 336-7. PMID 9241268 DOI: 10.1038/Ng0897-336 |
0.722 |
|
| 1997 |
Brugarolas J, Jacks T. Double indemnity: p53, BRCA and cancer. p53 mutation partially rescues developmental arrest in Brca1 and Brca2 null mice, suggesting a role for familial breast cancer genes in DNA damage repair. Nature Medicine. 3: 721-2. PMID 9212093 DOI: 10.1038/Nm0797-721 |
0.745 |
|
| 1997 |
McClatchey AI, Saotome I, Ramesh V, Gusella JF, Jacks T. The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation. Genes & Development. 11: 1253-65. PMID 9171370 DOI: 10.1101/Gad.11.10.1253 |
0.569 |
|
| 1997 |
van der Geer P, Henkemeyer M, Jacks T, Pawson T. Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-Gap. Molecular and Cellular Biology. 17: 1840-7. PMID 9121432 DOI: 10.1128/Mcb.17.4.1840 |
0.542 |
|
| 1997 |
Cichowski K, Shih TS, Jacks T. Nf1 gene targeting: toward models and mechanisms. Seminars in Cancer Biology. 7: 291-8. PMID 9110406 DOI: 10.1006/Scbi.1996.0037 |
0.807 |
|
| 1997 |
Collins K, Jacks T, Pavletich NP. The cell cycle and cancer Proceedings of the National Academy of Sciences of the United States of America. 94: 2776-2778. PMID 9096291 DOI: 10.1073/Pnas.94.7.2776 |
0.53 |
|
| 1997 |
Silva AJ, Frankland PW, Marowitz Z, Friedman E, Laszlo GS, Cioffi D, Jacks T, Bourtchuladze R, Lazlo G. A mouse model for the learning and memory deficits associated with neurofibromatosis type I. Nature Genetics. 15: 281-4. PMID 9054942 DOI: 10.1038/Ng0397-281 |
0.473 |
|
| 1997 |
Lowe SW, Jacks T. p53 and treatment of bladder cancer Nature. 385: 124-125. DOI: 10.1038/385124a0 |
0.654 |
|
| 1996 |
Jacks T. Tumor Suppressor Gene Mutations In Mice Annual Review of Genetics. 30: 603-636. PMID 8982467 DOI: 10.1146/Annurev.Genet.30.1.603 |
0.592 |
|
| 1996 |
Novitch BG, Mulligan GJ, Jacks T, Lassar AB. Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle. The Journal of Cell Biology. 135: 441-56. PMID 8896600 DOI: 10.1083/Jcb.135.2.441 |
0.55 |
|
| 1996 |
Williams BO, Jacks T. Mechanisms of carcinogenesis and the mutant mouse Current Opinion in Genetics and Development. 6: 65-70. PMID 8791481 DOI: 10.1016/S0959-437X(96)90012-X |
0.773 |
|
| 1996 |
Nacht M, Strasser A, Chan YR, Harris AW, Schlissel M, Bronson RT, Jacks T. Mutations in the p53 and SCID genes cooperate in tumorigenesis Genes and Development. 10: 2055-2066. PMID 8769648 DOI: 10.1101/Gad.10.16.2055 |
0.813 |
|
| 1996 |
Cobrinik D, Lee MH, Hannon G, Mulligan G, Bronson RT, Dyson N, Harlow E, Beach D, Weinberg RA, Jacks T. Shared role of the pRB-related p130 and p107 proteins in limb development. Genes & Development. 10: 1633-44. PMID 8682294 DOI: 10.1101/Gad.10.13.1633 |
0.809 |
|
| 1996 |
Lee MH, Williams BO, Mulligan G, Mukai S, Bronson RT, Dyson N, Harlow E, Jacks T. Targeted disruption of p107: functional overlap between p107 and Rb. Genes & Development. 10: 1621-32. PMID 8682293 DOI: 10.1101/Gad.10.13.1621 |
0.814 |
|
| 1996 |
Yamasaki L, Jacks T, Bronson R, Goillot E, Harlow E, Dyson NJ. Tumor induction and tissue atrophy in mice lacking E2F-1. Cell. 85: 537-48. PMID 8653789 DOI: 10.1016/S0092-8674(00)81254-4 |
0.597 |
|
| 1996 |
Jacks T, Weinberg RA. Cell-cycle control and its watchman. Nature. 381: 643-4. PMID 8649505 DOI: 10.1038/381643A0 |
0.696 |
|
| 1996 |
Jacks T. Lessons from the p53 mutant mouse Journal of Cancer Research and Clinical Oncology. 122: 319-327. PMID 8642041 DOI: 10.1007/Bf01220798 |
0.569 |
|
| 1996 |
Herrera RE, Sah VP, Williams BO, Mäkelä TP, Weinberg RA, Jacks T. Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts Molecular and Cellular Biology. 16: 2402-2407. PMID 8628308 DOI: 10.1128/Mcb.16.5.2402 |
0.802 |
|
| 1996 |
Bollag G, Clapp DW, Shih S, Adler F, Zhang YY, Thompson P, Lange BJ, Freedman MH, McCormick F, Jacks T, Shannon K. Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells. Nature Genetics. 12: 144-8. PMID 8563751 DOI: 10.1038/Ng0296-144 |
0.787 |
|
| 1996 |
Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW, Giaccia AJ. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature. 379: 88-91. PMID 8538748 DOI: 10.1038/379088A0 |
0.715 |
|
| 1996 |
Bollag G, Clapp DW, Shih S, Adler F, Zhang YY, Thompson P, Lange BJ, Freedman MH, McCormick F, Jacks T, Shannon K. Erratum: Corrigendum: Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells Nature Genetics. 12: 458-458. DOI: 10.1038/Ng0496-458C |
0.773 |
|
| 1996 |
Macleod KF, Hu Y, Jacks T. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. The Embo Journal. 15: 6178-6188. DOI: 10.1002/J.1460-2075.1996.Tb01006.X |
0.814 |
|
| 1996 |
Attardi LD, Lowe SW, Brugarolas J, Jacks T. Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis. The Embo Journal. 15: 3693-3701. DOI: 10.1002/J.1460-2075.1996.Tb00739.X |
0.811 |
|
| 1995 |
Tischler AS, Shih TS, Williams BO, Jacks T. Characterization of Pheochromocytomas in a Mouse Strain with a Targeted Disruptive Mutation of the Neurofibromatosis Gene Nf1. Endocrine Pathology. 6: 323-335. PMID 12114814 DOI: 10.1007/Bf02738732 |
0.787 |
|
| 1995 |
Macleod KF, Sherry N, Hannon G, Beach D, Tokino T, Kinzler K, Vogelstein B, Jacks T. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes & Development. 9: 935-44. PMID 7774811 DOI: 10.1101/Gad.9.8.935 |
0.797 |
|
| 1995 |
Sah VP, Attardi LD, Mulligan GJ, Williams BO, Bronson RT, Jacks T. A subset of p53-deficient embryos exhibit exencephaly Nature Genetics. 10: 175-180. PMID 7663512 DOI: 10.1038/Ng0695-175 |
0.798 |
|
| 1995 |
Mombaerts P, Terhorst C, Jacks T, Tonegawa S, Sancho J. Characterization of immature thymocyte lines derived from T-cell receptor or recombination activating gene 1 and p53 double mutant mice. Proceedings of the National Academy of Sciences of the United States of America. 92: 7420-4. PMID 7638208 DOI: 10.1073/Pnas.92.16.7420 |
0.502 |
|
| 1995 |
Brugarolas J, Chandrasekaran C, Gordon JI, Beach D, Jacks T, Hannon GJ. Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature. 377: 552-7. PMID 7566157 DOI: 10.1038/377552A0 |
0.749 |
|
| 1995 |
Henkemeyer M, Rossi DJ, Holmyard DP, Puri MC, Mbamalu G, Harpal K, Shih TS, Jacks T, Pawson T. Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein. Nature. 377: 695-701. PMID 7477259 DOI: 10.1038/377695A0 |
0.568 |
|
| 1995 |
Tischler AS, Shih TS, Williams BO, Jacks T. Characterization of pheochromocytomas in a mouse strain with a targeted disruptive mutation of the neurofibromatosis gene Nf1 Endocrine Pathology. 6: 323-335. DOI: 10.1007/BF02738732 |
0.776 |
|
| 1994 |
Hickey G, Jacks T, Judith F, Taylor J, Schoen WR, Krupa D, Cunningham P, Clark J, Smith RG. Efficacy and specificity of L-692,429, a novel nonpeptidyl growth hormone secretagogue, in beagles. Endocrinology. 134: 695-701. PMID 8299565 DOI: 10.1210/endo.134.2.8299565 |
0.37 |
|
| 1994 |
Slebos RJC, Lee MH, Plunkett BS, Kessis TD, Williams BO, Jacks T, Hedrick L, Kastan MB, Cho KR. p53-Dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein Proceedings of the National Academy of Sciences of the United States of America. 91: 5320-5324. PMID 8202487 DOI: 10.1073/Pnas.91.12.5320 |
0.745 |
|
| 1994 |
Lowe SW, Jacks T, Housman DE, Ruley HE. Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells. Proceedings of the National Academy of Sciences of the United States of America. 91: 2026-30. PMID 8134344 DOI: 10.1073/Pnas.91.6.2026 |
0.732 |
|
| 1994 |
Morgenbesser SD, Williams BO, Jacks T, Depinho RA. P53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens Nature. 371: 72-74. PMID 8072529 DOI: 10.1038/371072A0 |
0.777 |
|
| 1994 |
Symonds H, Krall L, Remington L, Saenz-Robles M, Lowe S, Jacks T, Dyke TV. p53-Dependent apoptosis suppresses tumor growth and progression in vivo Cell. 78: 703-711. PMID 8069917 DOI: 10.1016/0092-8674(94)90534-7 |
0.724 |
|
| 1994 |
Ziegler A, Jonason AS, Leffellt DJ, Simon JA, Sharma HW, Kimmelman J, Remington L, Jacks T, Brash DE. Sunburn and p53 in the onset of skin cancer Nature. 372: 773-776. PMID 7997263 DOI: 10.1038/372773A0 |
0.571 |
|
| 1994 |
Lowe SW, Bodis S, McClatchey A, Remington L, Ruley HE, Fisher DE, Housman DE, Jacks T. p53 status and the efficacy of cancer therapy in vivo. Science (New York, N.Y.). 266: 807-10. PMID 7973635 DOI: 10.1126/Science.7973635 |
0.732 |
|
| 1994 |
Strasser A, Harris AW, Jacks T, Cory S. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell. 79: 329-39. PMID 7954799 DOI: 10.1016/0092-8674(94)90201-1 |
0.553 |
|
| 1994 |
Williams BO, Remington L, Albert DM, Mukai S, Bronson RT, Jacks T. Cooperative tumorigenic effects of germline mutations in Rb and p53 Nature Genetics. 7: 480-484. PMID 7951317 DOI: 10.1038/Ng0894-480 |
0.78 |
|
| 1994 |
Williams BO, Schmitt EM, Remington L, Bronson RT, Albert DM, Weinberg RA, Jacks T. Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences Embo Journal. 13: 4251-4259. PMID 7925270 DOI: 10.1002/J.1460-2075.1994.Tb06745.X |
0.827 |
|
| 1994 |
Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT, Weinberg RA. Tumor spectrum analysis in p53-mutant mice Current Biology. 4: 1-7. PMID 7922305 DOI: 10.1016/S0960-9822(00)00002-6 |
0.834 |
|
| 1994 |
Jacks T, Shih TS, Schmitt EM, Bronson RT, Bernards A, Weinberg RA. Tumour predisposition in mice heterozygous for a targeted mutation in Nf1 Nature Genetics. 7: 353-361. PMID 7920653 DOI: 10.1038/ng0794-353 |
0.668 |
|
| 1994 |
Williams BO, Morgenbesser SD, DePinho RA, Jacks T. Tumorigenic and developmental effects of combined germ-line mutations in Rb and p53 Cold Spring Harbor Symposia On Quantitative Biology. 59: 449-457. PMID 7587099 DOI: 10.1101/Sqb.1994.059.01.050 |
0.75 |
|
| 1994 |
Lowe SW, Bodis S, Bardeesy N, McClatchey A, Remington L, Ruley HE, Fisher DE, Jacks T, Pelletier J, Housman DE. Apoptosis and the prognostic significance of p53 mutation. Cold Spring Harbor Symposia On Quantitative Biology. 59: 419-26. PMID 7587096 |
0.668 |
|
| 1994 |
Cory S, Strasser A, Jacks T, Corcoran LM, Metz T, Harris AW, Adams JM. Enhanced cell survival and tumorigenesis. Cold Spring Harbor Symposia On Quantitative Biology. 59: 365-75. PMID 7587089 DOI: 10.1101/Sqb.1994.059.01.041 |
0.5 |
|
| 1994 |
Symonds H, Krall L, Remington L, Robles MS, Jacks T, Dyke TV. p53-dependent apoptosis in vivo: impact of p53 inactivation on tumorigenesis. Cold Spring Harbor Symposia On Quantitative Biology. 59: 247-257. PMID 7587076 DOI: 10.1101/Sqb.1994.059.01.029 |
0.523 |
|
| 1994 |
Hatakeyama M, Herrera RA, Makela T, Dowdy SF, Jacks T, Weinberg RA. The cancer cell and the cell cycle clock. Cold Spring Harbor Symposia On Quantitative Biology. 59: 1-10. PMID 7587058 DOI: 10.1101/Sqb.1994.059.01.003 |
0.7 |
|
| 1994 |
Fisher DE, Bodis S, Lowe SW, Earl Ruley H, Housman DE, Jacks T. p53 dependnet sensitivity to radiation in a transplanted tumor model International Journal of Radiation Oncology*Biology*Physics. 30: 225. DOI: 10.1016/0360-3016(94)90749-8 |
0.676 |
|
| 1993 |
Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature. 362: 847-9. PMID 8479522 DOI: 10.1038/362847A0 |
0.719 |
|
| 1993 |
Berges RR, Furuya Y, Remington L, English HF, Jacks T, Isaacs JT. Cell proliferation, DNA repair, and p53 function are not required for programmed death of prostatic glandular cells induced by androgen ablation. Proceedings of the National Academy of Sciences of the United States of America. 90: 8910-4. PMID 8415631 DOI: 10.1073/Pnas.90.19.8910 |
0.507 |
|
| 1993 |
Lowe SW, Ruley HE, Jacks T, Housman DE. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell. 74: 957-67. PMID 8402885 DOI: 10.1016/0092-8674(93)90719-7 |
0.711 |
|
| 1993 |
Gregory PE, Gutmann DH, Mitchell A, Park S, Boguski M, Jacks T, Wood DL, Jove R, Collins FS. Neurofibromatosis type 1 gene product (neurofibromin) associates with microtubules. Somatic Cell and Molecular Genetics. 19: 265-74. PMID 8332934 DOI: 10.1007/Bf01233074 |
0.491 |
|
| 1993 |
Cobrinik D, Whyte P, Peeper DS, Jacks T, Weinberg RA. Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes & Development. 7: 2392-404. PMID 8253385 DOI: 10.1101/Gad.7.12A.2392 |
0.69 |
|
| 1993 |
Corcoran LM, Karvelas M, Nossal GJ, Ye ZS, Jacks T, Baltimore D. Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival. Genes & Development. 7: 570-82. PMID 8096198 DOI: 10.1101/Gad.7.4.570 |
0.527 |
|
| 1992 |
Kastan MB, Zhan Q, el-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B, Fornace AJ. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell. 71: 587-97. PMID 1423616 DOI: 10.1016/0092-8674(92)90593-2 |
0.6 |
|
| 1992 |
Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA. Effects of an Rb mutation in the mouse Nature. 359: 295-300. PMID 1406933 DOI: 10.1038/359295A0 |
0.719 |
|
| 1992 |
Livingstone LR, White A, Sprouse J, Livanos E, Jacks T, Tlsty TD. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell. 70: 923-35. PMID 1356076 DOI: 10.1016/0092-8674(92)90243-6 |
0.582 |
|
| 1990 |
Jacks T. Translational suppression in gene expression in retroviruses and retrotransposons. Current Topics in Microbiology and Immunology. 157: 93-124. PMID 2168307 DOI: 10.1007/978-3-642-75218-6_4 |
0.494 |
|
| 1990 |
SETTLEMAN J, HINDS P, COBRINIK D, JACKS T, MITTNACHT S, TEMPLETON D, PARK S, WEINBERG R. Studies on the mechanism of cell growth suppression by the retinoblastoma gene Cell Biology International Reports. 14: 21. DOI: 10.1016/0309-1651(90)90195-5 |
0.662 |
|
| 1988 |
Jacks T, Madhani HD, Masiarz FR, Varmus HE. Signals for ribosomal frameshifting in the rous sarcoma virus gag-pol region Cell. 55: 447-458. PMID 2846182 DOI: 10.1016/0092-8674(88)90031-1 |
0.67 |
|
| 1988 |
Jacks T, Power MD, Masiarz FR, Luciw PA, Barr PJ, Varmus HE. Characterization of ribosomal frameshifting in HIV-1 gag-pol expression Nature. 331: 280-283. PMID 2447506 DOI: 10.1038/331280A0 |
0.652 |
|
| 1987 |
Jacks T, Townsley K, Varmus HE, Majors J. Two efficient ribosomal frameshifting events are required for synthesis of mouse mammary tumor virus gag-related polyproteins Proceedings of the National Academy of Sciences of the United States of America. 84: 4298-4302. PMID 3035577 DOI: 10.1073/Pnas.84.12.4298 |
0.677 |
|
| 1985 |
Jacks T, Varmus HE. Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting Science. 230: 1237-1242. PMID 2416054 DOI: 10.1126/Science.2416054 |
0.668 |
|
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