Matthew R. Redinbo - Publications

Affiliations: 
Chemistry University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Structural Studies of Dynamic Cellular Processes
Website:
http://www.chem.unc.edu/people/faculty/redinbo/

134 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Sarosh A, Kwong SM, Jensen SO, Northern F, Walton WG, Eakes TC, Redinbo MR, Firth N, McLaughlin KJ. pSK41/pGO1-family conjugative plasmids of Staphylococcus aureus encode a cryptic repressor of replication. Plasmid. 128: 102708. PMID 37967733 DOI: 10.1016/j.plasmid.2023.102708  0.791
2020 Ervin SM, Simpson JB, Gibbs ME, Creekmore BC, Lim L, Walton WG, Gharaibeh RZ, Redinbo MR. Structural Insights into Endobiotic Reactivation by Human Gut Microbiome-Encoded Sulfatases. Biochemistry. PMID 32993284 DOI: 10.1021/acs.biochem.0c00711  0.318
2020 Ervin SM, Redinbo MR. The Gut Microbiota Impacts Cancer Etiology through "Phase IV Metabolism" of Drugs and Endobiotics. Cancer Prevention Research (Philadelphia, Pa.). PMID 32611614 DOI: 10.1158/1940-6207.Capr-20-0155  0.314
2020 Bhatt AP, Pellock SJ, Biernat KA, Walton WG, Wallace BD, Creekmore BC, Letertre MM, Swann JR, Wilson ID, Roques JR, Darr DB, Bailey ST, Montgomery SA, Roach JM, Azcarate-Peril MA, ... ... Redinbo MR, et al. Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy. Proceedings of the National Academy of Sciences of the United States of America. PMID 32170007 DOI: 10.1073/Pnas.1918095117  0.719
2020 Bartolini D, De Franco F, Torquato P, Marinelli R, Cerra B, Ronchetti R, Schön A, Fallarino F, De Luca A, Bellezza G, Ferri I, Sidoni A, Walton WG, Pellock SJ, Redinbo MR, et al. Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. Journal of Medicinal Chemistry. PMID 32160459 DOI: 10.1021/Acs.Jmedchem.0C00012.S001  0.339
2020 Dvořák Z, Kopp F, Costello CM, Kemp JS, Li H, Vrzalová A, Štěpánková M, Bartoňková I, Jiskrová E, Poulíková K, Vyhlídalová B, Nordstroem LU, Karunaratne CV, Ranhotra HS, Mun KS, ... ... Redinbo MR, et al. Targeting the pregnane X receptor using microbial metabolite mimicry. Embo Molecular Medicine. e11621. PMID 32153125 DOI: 10.15252/Emmm.201911621  0.385
2020 Redinbo M. Abstract IA01: Molecular control of the gut microbiome to improve cancer chemotherapy Cancer Research. 80. DOI: 10.1158/1538-7445.Mvc2020-Ia01  0.353
2019 Jariwala PB, Pellock SJ, Goldfarb D, Cloer EW, Artola M, Simpson JB, Bhatt AP, Walton WG, Roberts LR, Major MB, Davies GJ, Overkleeft HS, Redinbo MR. Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling. Acs Chemical Biology. PMID 31774274 DOI: 10.1021/Acschembio.9B00788  0.39
2019 Ervin SM, Hanley RP, Lim L, Walton WG, Pearce KH, Bhatt AP, James LI, Redinbo MR. Targeting regorafenib-induced toxicity through inhibition of gut microbial β-glucuronidases. Acs Chemical Biology. PMID 31663730 DOI: 10.1021/Acschembio.9B00663  0.383
2019 Ervin SM, Li H, Lim L, Roberts LR, Liang X, Mani S, Redinbo MR. Gut microbiome-derived β-glucuronidases are components of the estrobolome that reactivate estrogens. The Journal of Biological Chemistry. PMID 31636122 DOI: 10.1074/Jbc.Ra119.010950  0.378
2019 Pellock SJ, Walton WG, Redinbo MR. Selecting a Single Stereocenter: The Molecular Nuances that Differentiate β-Hexuronidases in the Human Gut Microbiome. Biochemistry. PMID 30729778 DOI: 10.2210/Pdb6Ncw/Pdb  0.42
2019 Biernat KA, Pellock SJ, Bhatt AP, Bivins MM, Walton WG, Tran BNT, Wei L, Snider MC, Cesmat AP, Tripathy A, Erie DA, Redinbo MR. Structure, function, and inhibition of drug reactivating human gut microbial β-glucuronidases. Scientific Reports. 9: 825. PMID 30696850 DOI: 10.1038/s41598-018-36069-w  0.638
2019 Pellock SJ, Walton WG, Ervin SM, Torres-Rivera D, Creekmore BC, Bergan G, Dunn ZD, Li B, Tripathy A, Redinbo MR. Discovery and Characterization of FMN-Binding β-Glucuronidases in the Human Gut Microbiome. Journal of Molecular Biology. PMID 30658055 DOI: 10.1016/J.Jmb.2019.01.013  0.43
2019 Biernat KA, Pellock SJ, Bhatt AP, Bivins MM, Walton WG, Tran BNT, Wei L, Snider MC, Cesmat AP, Tripathy A, Erie DA, Redinbo MR. Structure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Scientific Reports. 9: 825-825. DOI: 10.2210/Pdb6Ed2/Pdb  0.671
2018 Shapiro JA, Varga JJ, Parsonage D, Walton W, Redinbo MR, Ross LJ, White EL, Bostwick R, Wuest WM, Claiborne A, Goldberg JB. Identification of Specific and Non-specific Inhibitors of Bacillus anthracis Type III Pantothenate Kinase (PanK). Chemmedchem. PMID 30376607 DOI: 10.1002/Cmdc.201800652  0.309
2018 Pellock SJ, Walton WG, Biernat KA, Torres-Rivera D, Creekmore BC, Xu Y, Liu J, Tripathy A, Stewart LJ, Redinbo MR. . The Journal of Biological Chemistry. PMID 30301767 DOI: 10.1074/Jbc.Ra118.005414  0.446
2018 Little MS, Ervin SM, Walton WG, Tripathy A, Xu Y, Liu J, Redinbo MR. Active Site Flexibility Revealed in Crystal Structures of Parabacteroides merdae β-Glucuronidase from the Human Gut Microbiome. Protein Science : a Publication of the Protein Society. PMID 30230652 DOI: 10.1002/Pro.3507  0.434
2018 Pellock SJ, Creekmore BC, Walton WG, Mehta N, Biernat KA, Cesmat AP, Ariyarathna Y, Dunn ZD, Li B, Jin J, James LI, Redinbo MR. Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception. Acs Central Science. 4: 868-879. PMID 30062115 DOI: 10.1021/Acscentsci.8B00239  0.389
2018 Little MS, Redinbo MR. Crystal structure of the mouse innate immunity factor bacterial permeability-increasing family member A1. Acta Crystallographica. Section F, Structural Biology Communications. 74: 268-276. PMID 29717993 DOI: 10.1107/S2053230X18004600  0.349
2017 Little MS, Pellock SJ, Walton WG, Tripathy A, Redinbo MR. Structural basis for the regulation of β-glucuronidase expression by human gut Enterobacteriaceae. Proceedings of the National Academy of Sciences of the United States of America. PMID 29269393 DOI: 10.1073/Pnas.1716241115  0.479
2017 Pollet RM, D'Agostino EH, Walton WG, Xu Y, Little MS, Biernat KA, Pellock SJ, Patterson LM, Creekmore BC, Isenberg HN, Bahethi RR, Bhatt AP, Liu J, Gharaibeh RZ, Redinbo MR. An Atlas of β-Glucuronidases in the Human Intestinal Microbiome. Structure (London, England : 1993). PMID 28578872 DOI: 10.1016/J.Str.2017.05.003  0.785
2017 Pellock SJ, Redinbo MR. Glucuronides in the Gut: Sugar-Driven Symbioses Between Microbe and Host. The Journal of Biological Chemistry. PMID 28389557 DOI: 10.1074/Jbc.R116.767434  0.33
2017 Yu AM, Ingelman-Sundberg M, Cherrington NJ, Aleksunes LM, Zanger UM, Xie W, Jeong H, Morgan EM, Turnbaugh PJ, Klaassen CD, Bhatt AP, Redinbo MR, Hao P, Waxman DJ, Wang L, et al. Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21(st) International Symposium on Microsomes and Drug Oxidations (MDO). Acta Pharmaceutica Sinica. B. 7: 241-248. PMID 28388695 DOI: 10.1016/J.Apsb.2016.12.006  0.308
2017 Bellendir SP, Rognstad DJ, Morris LP, Zapotoczny G, Walton WG, Redinbo MR, Ramsden DA, Sekelsky J, Erie DA. Substrate preference of Gen endonucleases highlights the importance of branched structures as DNA damage repair intermediates. Nucleic Acids Research. PMID 28369583 DOI: 10.1093/Nar/Gkx214  0.663
2017 Redinbo MR. Microbial Molecules from the Multitudes within Us. Cell Metabolism. 25: 230-232. PMID 28178564 DOI: 10.1016/J.Cmet.2017.01.013  0.34
2016 Walton WG, Ahmad S, Little MR, Kim CS, Tyrrell JS, Lin Q, Di YP, Tarran R, Redinbo MR. Structural Features Essential to the Antimicrobial Functions of Human SPLUNC1. Biochemistry. PMID 27145151 DOI: 10.1021/Acs.Biochem.6B00271  0.388
2016 Ghodge SV, Biernat KA, Bassett SJ, Redinbo MR, Bowers AA. Post-Translational Claisen Condensation and Decarboxylation en Route to the Bicyclic Core of Pantocin A. Journal of the American Chemical Society. PMID 27088303 DOI: 10.1021/Jacs.5B13529  0.33
2016 Pollet RM, Ingle JD, Hymes JP, Eakes TC, Eto KY, Kwong SM, Ramsay JP, Firth N, Redinbo MR. Processing of Non-Conjugative Resistance Plasmids by Conjugation Nicking Enzyme of Staphylococci. Journal of Bacteriology. PMID 26728193 DOI: 10.1128/Jb.00832-15  0.793
2015 Wallace BD, Roberts AB, Pollet RM, Ingle JD, Biernat KA, Pellock SJ, Venkatesh MK, Guthrie L, O'Neal SK, Robinson SJ, Dollinger M, Figueroa E, McShane SR, Cohen RD, Jin J, ... ... Redinbo MR, et al. Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity. Chemistry & Biology. 22: 1238-49. PMID 26364932 DOI: 10.1016/J.Chembiol.2015.08.005  0.787
2015 Pollet R, Wallace B, Robers A, Boelsterli U, Mani S, Redinbo M. Pharmaceutical Control of the Microbiome The Faseb Journal. 29. DOI: 10.1096/Fasebj.29.1_Supplement.575.13  0.771
2014 McLaughlin KJ, Nash RP, Redinbo MR. Unique helicase determinants in the essential conjugative TraI factor from Salmonella enterica serovar Typhimurium plasmid pCU1. Journal of Bacteriology. 196: 3082-90. PMID 24936053 DOI: 10.1128/Jb.01496-14  0.795
2014 Mani S, Boelsterli UA, Redinbo MR. Understanding and modulating mammalian-microbial communication for improved human health. Annual Review of Pharmacology and Toxicology. 54: 559-80. PMID 24160697 DOI: 10.1146/Annurev-Pharmtox-011613-140007  0.332
2014 Saitta KS, Zhang C, Lee KK, Fujimoto K, Redinbo MR, Boelsterli UA. Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 44: 28-35. PMID 23829165 DOI: 10.3109/00498254.2013.811314  0.306
2013 Hobbs CA, Blanchard MG, Alijevic O, Tan CD, Kellenberger S, Bencharit S, Cao R, Kesimer M, Walton WG, Henderson AG, Redinbo MR, Stutts MJ, Tarran R. Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures. American Journal of Physiology. Lung Cellular and Molecular Physiology. 305: L990-L1001. PMID 24124190 DOI: 10.1152/Ajplung.00103.2013  0.618
2013 Garland AL, Walton WG, Coakley RD, Tan CD, Gilmore RC, Hobbs CA, Tripathy A, Clunes LA, Bencharit S, Stutts MJ, Betts L, Redinbo MR, Tarran R. Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways. Proceedings of the National Academy of Sciences of the United States of America. 110: 15973-8. PMID 24043776 DOI: 10.1073/Pnas.1311999110  0.581
2013 Cheng Y, Johnson MD, Burillo-Kirch C, Mocny JC, Anderson JE, Garrett CK, Redinbo MR, Thomas CE. Mutation of the conserved calcium-binding motif in Neisseria gonorrhoeae PilC1 impacts adhesion but not piliation. Infection and Immunity. 81: 4280-9. PMID 24002068 DOI: 10.1128/Iai.00493-13  0.565
2013 Marden JN, Diaz MR, Walton WG, Gode CJ, Betts L, Urbanowski ML, Redinbo MR, Yahr TL, Wolfgang MC. An unusual CsrA family member operates in series with RsmA to amplify posttranscriptional responses in Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences of the United States of America. 110: 15055-60. PMID 23980177 DOI: 10.1073/Pnas.1307217110  0.329
2013 Roberts AB, Wallace BD, Venkatesh MK, Mani S, Redinbo MR. Molecular insights into microbial β-glucuronidase inhibition to abrogate CPT-11 toxicity. Molecular Pharmacology. 84: 208-17. PMID 23690068 DOI: 10.1124/Mol.113.085852  0.744
2013 Wallace BD, Redinbo MR. The human microbiome is a source of therapeutic drug targets. Current Opinion in Chemical Biology. 17: 379-84. PMID 23680493 DOI: 10.1016/J.Cbpa.2013.04.011  0.729
2013 Hobbs CA, Blanchard MG, Kellenberger S, Bencharit S, Cao R, Kesimer M, Walton WG, Redinbo MR, Stutts MJ, Tarran R. Erratum: Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways (FASEB Journal (2012) 26 (4348-4359) doi:10.1096/fj.12-207431) The Faseb Journal. 27. PMID 23632283 DOI: 10.1096/Fj.12-207431Ret  0.58
2013 Wallace BD, Betts L, Talmage G, Pollet RM, Holman NS, Redinbo MR. Structural and functional analysis of the human nuclear xenobiotic receptor PXR in complex with RXRα. Journal of Molecular Biology. 425: 2561-77. PMID 23602807 DOI: 10.1016/J.Jmb.2013.04.012  0.809
2013 Li H, Redinbo MR, Venkatesh M, Ekins S, Chaudhry A, Bloch N, Negassa A, Mukherjee P, Kalpana G, Mani S. Novel yeast-based strategy unveils antagonist binding regions on the nuclear xenobiotic receptor PXR. The Journal of Biological Chemistry. 288: 13655-68. PMID 23525103 DOI: 10.1074/Jbc.M113.455485  0.377
2013 Edwards JS, Betts L, Frazier ML, Pollet RM, Kwong SM, Walton WG, Ballentine WK, Huang JJ, Habibi S, Del Campo M, Meier JL, Dervan PB, Firth N, Redinbo MR. Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America. 110: 2804-9. PMID 23359708 DOI: 10.1073/Pnas.1219701110  0.81
2013 Mani S, Dou W, Redinbo MR. PXR antagonists and implication in drug metabolism. Drug Metabolism Reviews. 45: 60-72. PMID 23330542 DOI: 10.3109/03602532.2012.746363  0.325
2013 Porsch EA, Johnson MD, Broadnax AD, Garrett CK, Redinbo MR, St Geme JW. Calcium binding properties of the Kingella kingae PilC1 and PilC2 proteins have differential effects on type IV pilus-mediated adherence and twitching motility. Journal of Bacteriology. 195: 886-95. PMID 23243304 DOI: 10.1128/Jb.02186-12  0.499
2013 Wallace BD, Redinbo MR. Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective. Drug Metabolism Reviews. 45: 79-100. PMID 23210723 DOI: 10.3109/03602532.2012.740049  0.735
2012 Wallace BD, Edwards JS, Wallen JR, Moolman WJ, van der Westhuyzen R, Strauss E, Redinbo MR, Claiborne A. Turnover-dependent covalent inactivation of Staphylococcus aureus coenzyme A-disulfide reductase by coenzyme A-mimetics: mechanistic and structural insights. Biochemistry. 51: 7699-711. PMID 22954034 DOI: 10.1021/Bi301026C  0.801
2012 Hobbs CA, Blanchard MG, Kellenberger S, Bencharit S, Cao R, Kesimer M, Walton WG, Redinbo MR, Stutts MJ, Tarran R. Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 4348-59. PMID 22798424 DOI: 10.1096/Fj.12-207431  0.597
2012 Nash RP, McNamara DE, Ballentine WK, Matson SW, Redinbo MR. Investigating the impact of bisphosphonates and structurally related compounds on bacteria containing conjugative plasmids. Biochemical and Biophysical Research Communications. 424: 697-703. PMID 22796221 DOI: 10.1016/J.Bbrc.2012.07.012  0.752
2012 LoGuidice A, Wallace BD, Bendel L, Redinbo MR, Boelsterli UA. Pharmacologic targeting of bacterial β-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice. The Journal of Pharmacology and Experimental Therapeutics. 341: 447-54. PMID 22328575 DOI: 10.1124/Jpet.111.191122  0.718
2012 Navaratnarajah P, Steele BL, Redinbo MR, Thompson NL. Rifampicin-independent interactions between the pregnane X receptor ligand binding domain and peptide fragments of coactivator and corepressor proteins. Biochemistry. 51: 19-31. PMID 22185585 DOI: 10.1016/J.Bpj.2011.11.1055  0.357
2012 Hemmert AC, Otto TC, Chica RA, Wierdl M, Edwards JS, Lewis SM, Edwards CC, Tsurkan L, Cadieux CL, Kasten SA, Cashman JR, Mayo SL, Potter PM, Cerasoli DM, Redinbo MR. Correction: Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme Plos One. 7. DOI: 10.1371/Annotation/C5953F27-95F8-4A1B-A46C-639D90E182Ac  0.552
2011 Johnson MD, Garrett CK, Bond JE, Coggan KA, Wolfgang MC, Redinbo MR. Pseudomonas aeruginosa PilY1 binds integrin in an RGD- and calcium-dependent manner. Plos One. 6: e29629. PMID 22242136 DOI: 10.1371/Journal.Pone.0029629  0.506
2011 Cheng Y, Frazier M, Lu F, Cao X, Redinbo MR. Crystal structure of the plant epigenetic protein arginine methyltransferase 10. Journal of Molecular Biology. 414: 106-22. PMID 21986201 DOI: 10.1016/J.Jmb.2011.09.040  0.686
2011 Cheng Y, Redinbo MR. Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721. Protein Science : a Publication of the Protein Society. 20: 1713-9. PMID 21805522 DOI: 10.1002/Pro.706  0.529
2011 Ahmad S, Hughes MA, Lane KT, Redinbo MR, Yeh LA, Scott JE. A High Throughput Assay for Discovery of Bacterial β-Glucuronidase Inhibitors. Current Chemical Genomics. 5: 13-20. PMID 21643506 DOI: 10.2174/1875397301105010013  0.338
2011 Edwards JS, Kumbhar A, Roberts A, Hemmert AC, Edwards CC, Potter PM, Redinbo MR. Immobilization of active human carboxylesterase 1 in biomimetic silica nanoparticles. Biotechnology Progress. 27: 863-9. PMID 21509954 DOI: 10.1002/Btpr.604  0.573
2011 Hemmert AC, Otto TC, Chica RA, Wierdl M, Edwards JS, Lewis SM, Lewis SL, Edwards CC, Tsurkan L, Cadieux CL, Kasten SA, Cashman JR, Mayo SL, Potter PM, Cerasoli DM, ... Redinbo MR, et al. Nerve agent hydrolysis activity designed into a human drug metabolism enzyme. Plos One. 6: e17441. PMID 21445272 DOI: 10.1371/Journal.Pone.0017441  0.604
2011 Nash RP, Niblock FC, Redinbo MR. Tyrosine partners coordinate DNA nicking by the Salmonella typhimurium plasmid pCU1 relaxase enzyme. Febs Letters. 585: 1216-22. PMID 21439279 DOI: 10.1016/J.Febslet.2011.03.043  0.779
2011 Lomino JV, Tripathy A, Redinbo MR. Triggered Mycobacterium tuberculosis heparin-binding hemagglutinin adhesin folding and dimerization. Journal of Bacteriology. 193: 2089-96. PMID 21398546 DOI: 10.1128/Jb.01231-10  0.786
2011 Cheng Y, McNamara DE, Miley MJ, Nash RP, Redinbo MR. Functional characterization of the multidomain F plasmid TraI relaxase-helicase. The Journal of Biological Chemistry. 286: 12670-82. PMID 21288910 DOI: 10.1074/Jbc.M110.207563  0.796
2011 Navaratnarajah P, Steele BL, Redinbo MR, Thompson NL. Nuclear Receptor (PXR), Ligand and Co-Activator Interactions Measured by Total Internal Reflection Fluorescence Microscopy Biophysical Journal. 100: 618a. DOI: 10.1016/J.Bpj.2010.12.3558  0.347
2010 Wallace BD, Wang H, Lane KT, Scott JE, Orans J, Koo JS, Venkatesh M, Jobin C, Yeh LA, Mani S, Redinbo MR. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science (New York, N.Y.). 330: 831-5. PMID 21051639 DOI: 10.1126/Science.1191175  0.794
2010 Parsonage D, Newton GL, Holder RC, Wallace BD, Paige C, Hamilton CJ, Dos Santos PC, Redinbo MR, Reid SD, Claiborne A. Characterization of the N-acetyl-α-D-glucosaminyl l-malate synthase and deacetylase functions for bacillithiol biosynthesis in Bacillus anthracis . Biochemistry. 49: 8398-414. PMID 20799687 DOI: 10.1021/Bi100698N  0.733
2010 Nash RP, Habibi S, Cheng Y, Lujan SA, Redinbo MR. The mechanism and control of DNA transfer by the conjugative relaxase of resistance plasmid pCU1. Nucleic Acids Research. 38: 5929-43. PMID 20448025 DOI: 10.1093/Nar/Gkq303  0.809
2010 Orans J, Johnson MD, Coggan KA, Sperlazza JR, Heiniger RW, Wolfgang MC, Redinbo MR. Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility. Proceedings of the National Academy of Sciences of the United States of America. 107: 1065-70. PMID 20080557 DOI: 10.1073/Pnas.0911616107  0.788
2010 Hemmert AC, Otto TC, Wierdl M, Edwards CC, Fleming CD, MacDonald M, Cashman JR, Potter PM, Cerasoli DM, Redinbo MR. Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin. Molecular Pharmacology. 77: 508-16. PMID 20051531 DOI: 10.1124/Mol.109.062356  0.758
2010 Radominska-Pandya A, Bratton SM, Redinbo MR, Miley MJ. The crystal structure of human UDP-glucuronosyltransferase 2B7 C-terminal end is the first mammalian UGT target to be revealed: the significance for human UGTs from both the 1A and 2B families. Drug Metabolism Reviews. 42: 133-44. PMID 19821783 DOI: 10.3109/03602530903209049  0.425
2010 Hemmert AC, Redinbo MR. A structural examination of agrochemical processing by human carboxylesterase 1 Journal of Pesticide Science. 35: 250-256. DOI: 10.1584/Jpestics.R10-05  0.442
2010 Orans J, Johnson MDL, Coggan KA, Sperlazza JR, Heiniger RW, Wolfgang MC, Redinbo MR. Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 3 (1065-1070) DOI:10.1073/pnas.0911616107) Proceedings of the National Academy of Sciences of the United States of America. 107: 5260. DOI: 10.1073/Pnas.1000441107  0.759
2009 Ekins S, Kortagere S, Iyer M, Reschly EJ, Lill MA, Redinbo MR, Krasowski MD. Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR. Plos Computational Biology. 5: e1000594. PMID 20011107 DOI: 10.1371/Journal.Pcbi.1000594  0.379
2009 Kennedy SA, Frazier ML, Steiniger M, Mast AM, Marzluff WF, Redinbo MR. Crystal structure of the HEAT domain from the Pre-mRNA processing factor Symplekin. Journal of Molecular Biology. 392: 115-28. PMID 19576221 DOI: 10.1016/J.Jmb.2009.06.062  0.722
2009 Biswas A, Mani S, Redinbo MR, Krasowski MD, Li H, Ekins S. Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists. Pharmaceutical Research. 26: 1807-15. PMID 19415465 DOI: 10.1007/S11095-009-9901-7  0.314
2009 Guogas LM, Kennedy SA, Lee JH, Redinbo MR. A novel fold in the TraI relaxase-helicase c-terminal domain is essential for conjugative DNA transfer. Journal of Molecular Biology. 386: 554-68. PMID 19136009 DOI: 10.1016/J.Jmb.2008.12.057  0.667
2008 Teotico DG, Bischof JJ, Peng L, Kliewer SA, Redinbo MR. Structural basis of human pregnane X receptor activation by the hops constituent colupulone. Molecular Pharmacology. 74: 1512-20. PMID 18768384 DOI: 10.1124/Mol.108.050732  0.44
2008 Teotico DG, Frazier ML, Ding F, Dokholyan NV, Temple BR, Redinbo MR. Active nuclear receptors exhibit highly correlated AF-2 domain motions. Plos Computational Biology. 4: e1000111. PMID 18617990 DOI: 10.1371/Journal.Pcbi.1000111  0.601
2008 Potts RG, Lujan SA, Redinbo MR. Winning the asymmetric war: new strategies for combating antibacterial resistance. Future Microbiology. 3: 119-23. PMID 18366330 DOI: 10.2217/17460913.3.2.119  0.667
2008 Schaaf G, Ortlund EA, Tyeryar KR, Mousley CJ, Ile KE, Garrett TA, Ren J, Woolls MJ, Raetz CR, Redinbo MR, Bankaitis VA. Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily. Molecular Cell. 29: 191-206. PMID 18243114 DOI: 10.1016/J.Molcel.2007.11.026  0.608
2008 Wierdl M, Tsurkan L, Hyatt JL, Edwards CC, Hatfield MJ, Morton CL, Houghton PJ, Danks MK, Redinbo MR, Potter PM. An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11. Cancer Gene Therapy. 15: 183-92. PMID 18188187 DOI: 10.1038/Sj.Cgt.7701112  0.349
2008 Wang H, Li H, Moore LB, Johnson MD, Maglich JM, Goodwin B, Ittoop OR, Wisely B, Creech K, Parks DJ, Collins JL, Willson TM, Kalpana GV, Venkatesh M, Xie W, ... ... Redinbo M, et al. The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor. Molecular Endocrinology (Baltimore, Md.). 22: 838-57. PMID 18096694 DOI: 10.1210/Me.2007-0218  0.569
2008 Xiong Y, Patana AS, Miley MJ, Zielinska AK, Bratton SM, Miller GP, Goldman A, Finel M, Redinbo MR, Radominska-Pandya A. The first aspartic acid of the DQxD motif for human UDP-glucuronosyltransferase 1A10 interacts with UDP-glucuronic acid during catalysis. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 517-22. PMID 18048489 DOI: 10.1124/Dmd.107.016469  0.371
2007 Ortlund EA, Bridgham JT, Redinbo MR, Thornton JW. Crystal structure of an ancient protein: evolution by conformational epistasis. Science (New York, N.Y.). 317: 1544-8. PMID 17702911 DOI: 10.1126/Science.1142819  0.626
2007 Lujan SA, Guogas LM, Ragonese H, Matson SW, Redinbo MR. Disrupting antibiotic resistance propagation by inhibiting the conjugative DNA relaxase. Proceedings of the National Academy of Sciences of the United States of America. 104: 12282-7. PMID 17630285 DOI: 10.1073/Pnas.0702760104  0.724
2007 Miley MJ, Zielinska AK, Keenan JE, Bratton SM, Radominska-Pandya A, Redinbo MR. Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7. Journal of Molecular Biology. 369: 498-511. PMID 17442341 DOI: 10.1016/J.Jmb.2007.03.066  0.428
2007 Wang H, Huang H, Li H, Teotico DG, Sinz M, Baker SD, Staudinger J, Kalpana G, Redinbo MR, Mani S. Activated pregnenolone X-receptor is a target for ketoconazole and its analogs. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 2488-95. PMID 17438109 DOI: 10.1158/1078-0432.Ccr-06-1592  0.404
2007 Fleming CD, Edwards CC, Kirby SD, Maxwell DM, Potter PM, Cerasoli DM, Redinbo MR. Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun. Biochemistry. 46: 5063-71. PMID 17407327 DOI: 10.1021/Bi700246N  0.785
2007 Xue Y, Moore LB, Orans J, Peng L, Bencharit S, Kliewer SA, Redinbo MR. Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition. Molecular Endocrinology (Baltimore, Md.). 21: 1028-38. PMID 17327420 DOI: 10.1210/Me.2006-0323  0.801
2007 Xue Y, Chao E, Zuercher WJ, Willson TM, Collins JL, Redinbo MR. Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism. Bioorganic & Medicinal Chemistry. 15: 2156-66. PMID 17215127 DOI: 10.1016/J.Bmc.2006.12.026  0.404
2007 Wadkins RM, Hyatt JL, Edwards CC, Tsurkan L, Redinbo MR, Wheelock CE, Jones PD, Hammock BD, Potter PM. Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds. Molecular Pharmacology. 71: 713-23. PMID 17167034 DOI: 10.1124/Mol.105.021683  0.35
2007 Huang H, Wang H, Sinz M, Zoeckler M, Staudinger J, Redinbo MR, Teotico DG, Locker J, Kalpana GV, Mani S. Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole. Oncogene. 26: 258-68. PMID 16819505 DOI: 10.1038/Sj.Onc.1209788  0.357
2007 Xue Y, Moore LB, Orans J, Peng L, Bencharit S, Kliewer SA, Redinbo MR. Erratum: Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition (Molecular Endocrinology (2007) 21, 5, (1028-1038)) Molecular Endocrinology. 21: 1488-1489. DOI: 10.1210/Me.2007-0000  0.784
2006 Bencharit S, Edwards CC, Morton CL, Howard-Williams EL, Kuhn P, Potter PM, Redinbo MR. Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1. Journal of Molecular Biology. 363: 201-14. PMID 16962139 DOI: 10.1016/J.Jmb.2006.08.025  0.674
2006 Noble SM, Carnahan VE, Moore LB, Luntz T, Wang H, Ittoop OR, Stimmel JB, Davis-Searles PR, Watkins RE, Wisely GB, LeCluyse E, Tripathy A, McDonnell DP, Redinbo MR. Human PXR forms a tryptophan zipper-mediated homodimer. Biochemistry. 45: 8579-89. PMID 16834332 DOI: 10.1021/Bi0602821  0.693
2006 Wierdl M, Wadkins R, Redinbo M, Tsurkan L, Potter P. 655. Development of a Human Carboxylesterase That Can Efficiently Metabolize CPT-11 Molecular Therapy. 13: S252. DOI: 10.1016/J.Ymthe.2006.08.731  0.347
2005 Solomon IH, Hager JM, Safi R, McDonnell DP, Redinbo MR, Ortlund EA. Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. Journal of Molecular Biology. 354: 1091-102. PMID 16289203 DOI: 10.1016/J.Jmb.2005.10.009  0.655
2005 Ingraham HA, Redinbo MR. Orphan nuclear receptors adopted by crystallography. Current Opinion in Structural Biology. 15: 708-15. PMID 16263271 DOI: 10.1016/J.Sbi.2005.10.009  0.362
2005 Huang H, Fleming CD, Nishi K, Redinbo MR, Hammock BD. Stereoselective hydrolysis of pyrethroid-like fluorescent substrates by human and other mammalian liver carboxylesterases. Chemical Research in Toxicology. 18: 1371-7. PMID 16167828 DOI: 10.1021/Tx050072+  0.759
2005 Carnahan VE, Redinbo MR. Structure and function of the human nuclear xenobiotic receptor PXR. Current Drug Metabolism. 6: 357-67. PMID 16101574 DOI: 10.2174/1389200054633844  0.407
2005 Fleming CD, Bencharit S, Edwards CC, Hyatt JL, Tsurkan L, Bai F, Fraga C, Morton CL, Howard-Williams EL, Potter PM, Redinbo MR. Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil. Journal of Molecular Biology. 352: 165-77. PMID 16081098 DOI: 10.1016/J.Jmb.2005.07.016  0.804
2005 Orans J, Teotico DG, Redinbo MR. The nuclear xenobiotic receptor pregnane X receptor: recent insights and new challenges. Molecular Endocrinology (Baltimore, Md.). 19: 2891-900. PMID 15961506 DOI: 10.1210/Me.2005-0156  0.78
2005 Redinbo MR, Potter PM. Mammalian carboxylesterases: from drug targets to protein therapeutics. Drug Discovery Today. 10: 313-25. PMID 15749280 DOI: 10.1016/S1359-6446(05)03383-0  0.373
2005 Ortlund EA, Lee Y, Solomon IH, Hager JM, Safi R, Choi Y, Guan Z, Tripathy A, Raetz CR, McDonnell DP, Moore DD, Redinbo MR. Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nature Structural & Molecular Biology. 12: 357-63. PMID 15723037 DOI: 10.1038/Nsmb910  0.638
2005 Chrencik JE, Orans J, Moore LB, Xue Y, Peng L, Collins JL, Wisely GB, Lambert MH, Kliewer SA, Redinbo MR. Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin. Molecular Endocrinology (Baltimore, Md.). 19: 1125-34. PMID 15705662 DOI: 10.1210/Me.2004-0346  0.803
2004 Antony S, Theruvathu JA, Brooks PJ, Lesher DT, Redinbo M, Pommier Y. Enhancement of camptothecin-induced topoisomerase I cleavage complexes by the acetaldehyde adduct N2-ethyl-2'-deoxyguanosine. Nucleic Acids Research. 32: 5685-92. PMID 15498925 DOI: 10.1093/nar/gkh902  0.785
2004 Chillemi G, Redinbo M, Bruselles A, Desideri A. Role of the linker domain and the 203-214 N-terminal residues in the human topoisomerase I DNA complex dynamics Biophysical Journal. 87: 4087-4097. PMID 15347588 DOI: 10.1529/Biophysj.104.044925  0.391
2004 Thapar R, Marzluff WF, Redinbo MR. Electrostatic contribution of serine phosphorylation to the Drosophila SLBP--histone mRNA complex. Biochemistry. 43: 9401-12. PMID 15260483 DOI: 10.1021/Bi036315J  0.306
2004 Chrencik JE, Staker BL, Burgin AB, Pourquier P, Pommier Y, Stewart L, Redinbo MR. Mechanisms of camptothecin resistance by human topoisomerase I mutations. Journal of Molecular Biology. 339: 773-84. PMID 15165849 DOI: 10.1016/J.Jmb.2004.03.077  0.796
2004 Wierdl M, Morton CL, Nguyen NK, Redinbo MR, Potter PM. Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model. Biochemistry. 43: 1874-82. PMID 14967028 DOI: 10.1021/Bi035586R  0.357
2003 Watkins RE, Davis-Searles PR, Lambert MH, Redinbo MR. Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor. Journal of Molecular Biology. 331: 815-28. PMID 12909012 DOI: 10.1016/S0022-2836(03)00795-2  0.415
2003 Redinbo MR, Bencharit S, Potter PM. Human carboxylesterase 1: from drug metabolism to drug discovery. Biochemical Society Transactions. 31: 620-4. PMID 12773168 DOI: 10.1042/Bst0310620  0.65
2003 Bencharit S, Morton CL, Hyatt JL, Kuhn P, Danks MK, Potter PM, Redinbo MR. Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition. Chemistry & Biology. 10: 341-9. PMID 12725862 DOI: 10.1016/S1074-5521(03)00071-1  0.686
2003 Bencharit S, Morton CL, Xue Y, Potter PM, Redinbo MR. Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme. Nature Structural Biology. 10: 349-56. PMID 12679808 DOI: 10.1038/Nsb919  0.655
2003 Watkins RE, Maglich JM, Moore LB, Wisely GB, Noble SM, Davis-Searles PR, Lambert MH, Kliewer SA, Redinbo MR. 2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin. Biochemistry. 42: 1430-8. PMID 12578355 DOI: 10.1021/Bi0268753  0.704
2003 Chrencik JE, Burgin AB, Pommier Y, Stewart L, Redinbo MR. Structural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complex. The Journal of Biological Chemistry. 278: 12461-6. PMID 12533542 DOI: 10.1074/Jbc.M212930200  0.783
2002 Lesher DT, Pommier Y, Stewart L, Redinbo MR. 8-Oxoguanine rearranges the active site of human topoisomerase I. Proceedings of the National Academy of Sciences of the United States of America. 99: 12102-7. PMID 12209008 DOI: 10.1073/Pnas.192282699  0.807
2002 Bencharit S, Morton CL, Howard-Williams EL, Danks MK, Potter PM, Redinbo MR. Structural insights into CPT-11 activation by mammalian carboxylesterases. Nature Structural Biology. 9: 337-42. PMID 11967565 DOI: 10.1038/Nsb790  0.661
2002 Watkins RE, Noble SM, Redinbo MR. Structural insights into the promiscuity and function of the human pregnane X receptor. Current Opinion in Drug Discovery & Development. 5: 150-8. PMID 11865669  0.688
2002 Xue Y, Ratcliff GC, Wang H, Davis-Searles PR, Gray MD, Erie DA, Redinbo MR. A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'- 5' exonuclease and 5'-protruding strand endonuclease activities. Biochemistry. 41: 2901-12. PMID 11863428 DOI: 10.1021/Bi0157161  0.648
2002 Goodwin B, Redinbo MR, Kliewer SA. Regulation of cyp3a gene transcription by the pregnane x receptor. Annual Review of Pharmacology and Toxicology. 42: 1-23. PMID 11807162 DOI: 10.1146/Annurev.Pharmtox.42.111901.111051  0.355
2002 Redinbo MR, Watkins RE, Noble SN, Wisely GB, Moore LB, Maglich JM, Kliewer SA. Front-line drug recognition in humans by the nuclear receptor PXR Acta Crystallographica Section a Foundations of Crystallography. 58: c201-c201. DOI: 10.1107/S0108767302093054  0.309
2002 Lesher D, Pommier Y, Stewart L, Redinbo MR. Structural impact of 8-oxoguanine on human topoisomerase I Acta Crystallographica Section a Foundations of Crystallography. 58: c121-c121. DOI: 10.1107/S0108767302089869  0.333
2001 Watkins RE, Wisely GB, Moore LB, Collins JL, Lambert MH, Williams SP, Willson TM, Kliewer SA, Redinbo MR. The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science (New York, N.Y.). 292: 2329-33. PMID 11408620 DOI: 10.1126/Science.1060762  0.422
2000 Redinbo MR, Champoux JJ, Hol WG. Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA. Biochemistry. 39: 6832-40. PMID 10841763 DOI: 10.1021/Bi992690T  0.622
1999 Redinbo MR, Stewart L, Champoux JJ, Hol WG. Structural flexibility in human topoisomerase I revealed in multiple non-isomorphous crystal structures. Journal of Molecular Biology. 292: 685-96. PMID 10497031 DOI: 10.1006/Jmbi.1999.3065  0.61
1999 Diller DJ, Redinbo MR, Pohl E, Hol WG. A database method for automated map interpretation in protein crystallography. Proteins. 36: 526-41. PMID 10450094 DOI: 10.1002/(Sici)1097-0134(19990901)36:4<526::Aid-Prot16>3.0.Co;2-F  0.541
1999 Diller DJ, Pohl E, Redinbo MR, Hovey BT, Hol WG. A rapid method for positioning small flexible molecules, nucleic acids, and large protein fragments in experimental electron density maps. Proteins. 36: 512-25. PMID 10450093 DOI: 10.1002/(Sici)1097-0134(19990901)36:4<512::Aid-Prot15>3.0.Co;2-V  0.759
1999 Redinbo MR, Champoux JJ, Hol WG. Structural insights into the function of type IB topoisomerases. Current Opinion in Structural Biology. 9: 29-36. PMID 10047584 DOI: 10.1016/S0959-440X(99)80005-0  0.625
1998 Stewart L, Redinbo MR, Qiu X, Hol WG, Champoux JJ. A model for the mechanism of human topoisomerase I. Science (New York, N.Y.). 279: 1534-41. PMID 9488652 DOI: 10.1126/Science.279.5356.1534  0.623
1998 Redinbo MR, Stewart L, Kuhn P, Champoux JJ, Hol WG. Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science (New York, N.Y.). 279: 1504-13. PMID 9488644 DOI: 10.1126/Science.279.5356.1504  0.621
1996 Redinbo MR, Eide SM, Stone RL, Dixon JE, Yeates TO. Crystallization and preliminary structural analysis of Bacillus subtilis adenylosuccinate lyase, an enzyme implicated in infantile autism. Protein Science : a Publication of the Protein Society. 5: 786-8. PMID 8845770 DOI: 10.1002/Pro.5560050425  0.581
1996 Redinbo MR, Stewart L, Pohl E, Qiu X, Champoux JJ, Hol WGJ. Progress in the structure determination of a human topoisomerase I–DNA complex Acta Crystallographica Section a Foundations of Crystallography. 52: C159-C159. DOI: 10.1107/S0108767396092896  0.345
1994 Redinbo MR, Yeates TO, Merchant S. Plastocyanin: structural and functional analysis. Journal of Bioenergetics and Biomembranes. 26: 49-66. PMID 8027022 DOI: 10.1007/Bf00763219  0.691
1993 Redinbo MR, Yeates TO. Structure determination of plastocyanin from a specimen with a hemihedral twinning fraction of one-half. Acta Crystallographica. Section D, Biological Crystallography. 49: 375-80. PMID 15299512 DOI: 10.1107/S090744499300294X  0.552
1993 Redinbo MR, Cascio D, Choukair MK, Rice D, Merchant S, Yeates TO. The 1.5-A crystal structure of plastocyanin from the green alga Chlamydomonas reinhardtii. Biochemistry. 32: 10560-7. PMID 8399201 DOI: 10.1021/Bi00091A005  0.673
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