Year |
Citation |
Score |
2023 |
Chen J, Garcia EJ, Merritt CR, Zamora JC, Bolinger AA, Pazdrak K, Stafford SJ, Mifflin RC, Wold EA, Wild CT, Chen H, Anastasio NC, Cunningham KA, Zhou J. Discovery of Novel Oleamide Analogues as Brain-Penetrant Positive Allosteric Serotonin 5-HT Receptor and Dual 5-HT/5-HT Receptor Modulators. Journal of Medicinal Chemistry. PMID 37462530 DOI: 10.1021/acs.jmedchem.3c00908 |
0.43 |
|
2022 |
Liu Z, Li Y, Chen H, Lai HT, Wang P, Wu SY, Wold EA, Leonard PG, Joseph S, Hu H, Chiang CM, Brasier AR, Tian B, Zhou J. Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site. Journal of Medicinal Chemistry. PMID 34982556 DOI: 10.1021/acs.jmedchem.1c01851 |
0.45 |
|
2021 |
Liu Z, Wang P, Wold EA, Song Q, Zhao C, Wang C, Zhou J. Small-Molecule Inhibitors Targeting the Canonical WNT Signaling Pathway for the Treatment of Cancer. Journal of Medicinal Chemistry. PMID 33822624 DOI: 10.1021/acs.jmedchem.0c01799 |
0.469 |
|
2021 |
Xu J, Berastegui-Cabrera J, Carretero-Ledesma M, Chen H, Xue Y, Wold EA, Pachón J, Zhou J, Sánchez-Céspedes J. Discovery of a Small Molecule Inhibitor of Human Adenovirus Capable of Preventing Escape from the Endosome. International Journal of Molecular Sciences. 22. PMID 33562748 DOI: 10.3390/ijms22041617 |
0.397 |
|
2020 |
Ye N, Qin W, Tian S, Xu Q, Wold EA, Zhou J, Zhen XC. Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases. Journal of Medicinal Chemistry. PMID 33111525 DOI: 10.1021/acs.jmedchem.0c01192 |
0.477 |
|
2020 |
Wold EA, Garcia EJ, Wild C, Miszkiel JM, Soto CA, Chen J, Pazdrak K, Fox RG, Anastasio NC, Cunningham KA, Zhou J. Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2C Receptor Positive Allosteric Modulators with Enhanced Drug-Like Properties. Journal of Medicinal Chemistry. PMID 32567857 DOI: 10.1021/Acs.Jmedchem.9B01953 |
0.557 |
|
2020 |
Liu Z, Chen H, Wang P, Li Y, Wold EA, Leonard PG, Joseph S, Brasier AR, Tian B, Zhou J. Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffolding Hopping, Optimization and Pharmacological Evaluation. Journal of Medicinal Chemistry. PMID 32255647 DOI: 10.1021/Acs.Jmedchem.0C00035 |
0.538 |
|
2019 |
Wold EA, Wild CT, Cunningham KA, Zhou J. Targeting the 5-HT2C Receptor in Biological Context and the Current State of 5-HT2C Receptor Ligand Development. Current Topics in Medicinal Chemistry. PMID 31288724 DOI: 10.2174/1568026619666190709101449 |
0.514 |
|
2019 |
Liu G, Yin T, Kim H, Ding C, Yu Z, Wang H, Chen H, Yan R, Wold EA, Zou H, Liu X, Ding Y, Shen Q, Zhou J. Structure-activity relationship studies on Bax activator SMBA1 for the treatment of ER-positive and triple-negative breast cancer. European Journal of Medicinal Chemistry. 178: 589-605. PMID 31220676 DOI: 10.1016/J.Ejmech.2019.06.004 |
0.474 |
|
2019 |
Liu G, Wold EA, Zhou J. Applications of Bioorthogonal Chemistry in Tumor-Targeted Drug Discovery. Current Topics in Medicinal Chemistry. PMID 31074366 DOI: 10.2174/1568026619666190510091921 |
0.488 |
|
2018 |
Wold EA, Zhou J. GPCR Allosteric Modulators: Mechanistic Advantages and Therapeutic Applications. Current Topics in Medicinal Chemistry. 18: 2002-2006. PMID 30621563 DOI: 10.2174/1568026619999190101151837 |
0.486 |
|
2018 |
Ye N, Li B, Mao Q, Wold EA, Tian S, Allen JA, Zhou J. Orphan Receptor GPR88 as an Emerging Neurotherapeutic Target. Acs Chemical Neuroscience. PMID 30540906 DOI: 10.1021/Acschemneuro.8B00572 |
0.537 |
|
2018 |
Wold EA, Chen J, Cunningham KA, Zhou J. Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts. Journal of Medicinal Chemistry. PMID 30106578 DOI: 10.1021/Acs.Jmedchem.8B00875 |
0.571 |
|
2018 |
Wild CT, Miszkiel JM, Wold EA, Soto CA, Ding C, Hartley RM, White MA, Anastasio NC, Cunningham KA, Zhou J. Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-Carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT2C Receptor. Journal of Medicinal Chemistry. PMID 29620897 DOI: 10.1021/Acs.Jmedchem.8B00401 |
0.485 |
|
2018 |
Ding Y, Li D, Ding C, Wang P, Liu Z, Wold EA, Ye N, Chen H, White MA, Shen Q, Zhou J. Regio- and Stereospecific Synthesis of Oridonin D-ring Aziridinated Analogues for the Treatment of Triple-Negative Breast Cancer via Mediated Irreversible Covalent Warheads. Journal of Medicinal Chemistry. PMID 29528645 DOI: 10.1021/Acs.Jmedchem.7B01514 |
0.539 |
|
2018 |
Xu J, Wold EA, Ding Y, Shen Q, Zhou J. Therapeutic Potential of Oridonin and Its Analogs: From Anticancer and Antiinflammation to Neuroprotection. Molecules (Basel, Switzerland). 23. PMID 29470395 DOI: 10.3390/Molecules23020474 |
0.534 |
|
2018 |
Ding Y, Li D, Ding C, Liu Z, Wold EA, Ye N, Chen H, White MA, Shen Q, Zhou J. Abstract 2668: Regio- and stereospecific synthesis of oridonin D-ring aziridinated analogues for the treatment of triple-negative breast cancer via mediated irreversible covalent warheads Cancer Research. 78: 2668-2668. DOI: 10.1158/1538-7445.Am2018-2668 |
0.498 |
|
2017 |
Liu Z, Wang P, Chen H, Wold EA, Tian B, Brasier AR, Zhou J. Drug Discovery Targeting Bromodomain-Containing Protein 4 (BRD4). Journal of Medicinal Chemistry. PMID 28195723 DOI: 10.1021/Acs.Jmedchem.6B01761 |
0.533 |
|
2016 |
Ye N, Chen H, Wold EA, Shi PY, Zhou J. Therapeutic Potential of Spirooxindoles as Antiviral Agents. Acs Infectious Diseases. 2: 382-392. PMID 27627626 DOI: 10.1021/Acsinfecdis.6B00041 |
0.515 |
|
2016 |
Ding Y, Ding C, Ye N, Liu Z, Wold EA, Chen H, Wild C, Shen Q, Zhou J. Discovery and development of natural product oridonin-inspired anticancer agents. European Journal of Medicinal Chemistry. 122: 102-117. PMID 27344488 DOI: 10.1016/J.Ejmech.2016.06.015 |
0.566 |
|
2015 |
Liu Z, Wild C, Ding Y, Ye N, Chen H, Wold EA, Zhou J. BH4 domain of Bcl-2 as a novel target for cancer therapy. Drug Discovery Today. PMID 26631752 DOI: 10.1016/J.Drudis.2015.11.008 |
0.483 |
|
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