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Hang Hubert Yin - Publications

Affiliations: 
1995-1999 Applied Chemistry Peking University, Beijing, Beijing Shi, China 
 1999-2004 Chemistry Yale University, New Haven, CT 
 2004-2007 Biochemistry and Biophysics University of Pennsylvania Medical School, Philadelphia, PA, United States 
 2007-2018 Chemistry and BIochemistry University of Colorado, Boulder, Boulder, CO, United States 
 2018- School of Pharmaceutical Sciences Tsinghua National University, Beijing, Beijing Shi, China 
Area:
Chemical Biology, Drug Discovery
Website:
http://www.yinlab-tsinghua.cn
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Year Citation  Score
2020 Jiang X, Yuan Y, Huang J, Zhang S, Luo S, Wang N, Pu D, Zhao N, Tang Q, Hirata K, Yang X, Jiao Y, Sakata-Kato T, Wu JW, Yan C, ... ... Yin H, et al. Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum. Cell. PMID 32860739 DOI: 10.1016/J.Cell.2020.08.015  0.492
2020 Wang Y, Zhang S, Li H, Wang H, Zhang T, Hutchinson MR, Yin H, Wang X. Small-Molecule Modulators of Toll-like Receptors. Accounts of Chemical Research. PMID 32233400 DOI: 10.1021/Acs.Accounts.9B00631  0.617
2020 Jiang S, Tanji H, Yin K, Zhang S, Sakaniwa K, Huang J, Yang Y, Li J, Ohto U, Shimizu T, Yin HH. Rationally designed small-molecule inhibitors targeting an unconventional pocket on the TLR8 protein-protein interface. Journal of Medicinal Chemistry. PMID 32233366 DOI: 10.1021/Acs.Jmedchem.9B02128  0.689
2019 Russell AE, Sneider A, Witwer KW, Bergese P, Bhattacharyya SN, Cocks A, Cocucci E, Erdbrügger U, Falcon-Perez JM, Freeman DW, Gallagher TM, Hu S, Huang Y, Jay SM, Kano SI, ... ... Yin H, et al. Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop. Journal of Extracellular Vesicles. 8: 1684862. PMID 31762963 DOI: 10.1080/20013078.2019.1684862  0.331
2019 Padilla-Salinas R, Anderson R, Sakaniwa K, Zhang S, Nordeen P, Lu C, Shimizu T, Yin HH. Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-like Receptor 7 and 8. Journal of Medicinal Chemistry. PMID 31687820 DOI: 10.1021/Acs.Jmedchem.9B01201  0.668
2019 Peng Y, Zhang X, Zhang T, Grace PM, Li H, Wang Y, Li H, Chen H, Watkins LR, Hutchinson MR, Yin H, Wang X. Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain. Brain, Behavior, and Immunity. PMID 31542403 DOI: 10.1016/J.Bbi.2019.09.013  0.576
2019 Zhang Y, Jin X, Liang J, Guo Y, Sun G, Zeng X, Yin H. Extracellular vesicles derived from ODN-stimulated macrophages transfer and activate Cdc42 in recipient cells and thereby increase cellular permissiveness to EV uptake. Science Advances. 5: eaav1564. PMID 31355328 DOI: 10.1126/Sciadv.Aav1564  0.322
2019 Tamura R, Balabanova A, Frakes SA, Bargmann A, Grimm J, Koch TH, Yin HH. Photoactivatable Prodrug of Doxazolidine Targeting Exosomes. Journal of Medicinal Chemistry. PMID 30703330 DOI: 10.1021/Acs.Jmedchem.8B01508  0.325
2018 Hu Z, Tanji H, Jiang S, Zhang S, Koo K, Chan J, Sakaniwa K, Ohto U, Candia A, Shimizu T, Yin H. Small-Molecule TLR8 Antagonists via Structure-Based Rational Design. Cell Chemical Biology. PMID 30100350 DOI: 10.1016/J.Chembiol.2018.07.004  0.686
2018 Sammond DW, Kastelowitz N, Donohoe BS, Alahuhta M, Lunin VV, Chung D, Sarai NS, Yin H, Mittal A, Himmel ME, Guss AM, Bomble YJ. An iterative computational design approach to increase the thermal endurance of a mesophilic enzyme. Biotechnology For Biofuels. 11: 189. PMID 30002729 DOI: 10.1186/S13068-018-1178-9  0.695
2018 Bhattacharyya S, Wang W, Qin W, Cheng K, Coulup S, Chavez S, Jiang S, Raparia K, De Almeida LMV, Stehlik C, Tamaki Z, Yin H, Varga J. TLR4-dependent fibroblast activation drives persistent organ fibrosis in skin and lung. Jci Insight. 3. PMID 29997297 DOI: 10.1172/Jci.Insight.98850  0.515
2018 Zhang L, Shi L, Soars S, Kamps J, Yin HH. Discovery of Novel Small-molecule Inhibitors of Nuclear Factor-κB Signaling with Anti-inflammatory and Anti-cancer Properties. Journal of Medicinal Chemistry. PMID 29870245 DOI: 10.1021/Acs.Jmedchem.7B01557  0.338
2018 Grace PM, Wang X, Strand KA, Baratta MV, Zhang Y, Galer EL, Yin H, Maier SF, Watkins LR. DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats. Experimental Neurology. PMID 29530713 DOI: 10.1016/J.Expneurol.2018.03.005  0.539
2017 Zhang S, Hu Z, Tanji H, Jiang S, Das N, Li J, Sakaniwa K, Jin J, Bian Y, Ohto U, Shimizu T, Yin H. Small-molecule inhibition of TLR8 through stabilization of its resting state. Nature Chemical Biology. PMID 29155428 DOI: 10.1038/Nchembio.2518  0.75
2017 Bhattacharyya S, Midwood KS, Yin H, Varga J. Toll-Like Receptor-4 Signaling Drives Persistent Fibroblast Activation and Prevents Fibrosis Resolution in Scleroderma. Advances in Wound Care. 6: 356-369. PMID 29062592 DOI: 10.1089/Wound.2017.0732  0.322
2017 Kargas V, Marzinek JK, Holdbrook DA, Yin H, Ford RC, Bond PJ. A Polar SxxS Motif Drives Assembly of the Transmembrane Domains of Toll-Like Receptor 4. Biochimica Et Biophysica Acta. PMID 28739292 DOI: 10.1016/J.Bbamem.2017.07.010  0.403
2017 Kastelowitz N, Tamura R, Onasoga A, Stalker TJ, White OR, Brown PN, Brodsky GL, Brass LF, Branchford BR, Di Paola J, Yin H. Peptides derived from MARCKS block coagulation complex assembly on phosphatidylserine. Scientific Reports. 7: 4275. PMID 28655899 DOI: 10.1038/S41598-017-04494-Y  0.387
2017 Zhang L, Dewan V, Yin HH. Discovery of Small Molecules as Multi-Toll-like Receptor Agonists with Proinflammatory and Anticancer Activities. Journal of Medicinal Chemistry. PMID 28537730 DOI: 10.1021/Acs.Jmedchem.7B00419  0.665
2017 Zeng X, Wu P, Yao C, Liang J, Zhang ST, Yin HH. Small molecule and peptide recognition of protein transmembrane domains. Biochemistry. PMID 28353343 DOI: 10.1021/Acs.Biochem.6B00909  0.614
2017 Tamura R, Yin H. Rationally Designed Peptide Probes for Extracellular Vesicles. Advances in Clinical Chemistry. 79: 25-41. PMID 28212713 DOI: 10.1016/Bs.Acc.2016.09.001  0.408
2017 de Jesus AJ, Yin H. Computational Design of Membrane Curvature-Sensing Peptides. Methods in Molecular Biology (Clifton, N.J.). 1529: 417-437. PMID 27914065 DOI: 10.1007/978-1-4939-6637-0_22  0.8
2016 Das N, Dewan V, Grace PM, Gunn RJ, Tamura R, Tzarum N, Watkins LR, Wilson IA, Yin H. HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia. Cell Reports. 17: 1128-1140. PMID 27760316 DOI: 10.1016/J.Celrep.2016.09.076  0.776
2016 de Jesus AJ, White OR, Flynn AD, Yin H. Determinants of Curvature-Sensing Behavior for MARCKS-Fragment Peptides. Biophysical Journal. 110: 1980-92. PMID 27166806 DOI: 10.1016/J.Bpj.2016.04.007  0.805
2016 Flynn AD, Yin H. Lipid-Targeting Peptide Probes for Extracellular Vesicles. Journal of Cellular Physiology. PMID 26909741 DOI: 10.1002/Jcp.25354  0.394
2016 Yin H, Flynn AD. Drugging Membrane Protein Interactions. Annual Review of Biomedical Engineering. PMID 26863923 DOI: 10.1146/Annurev-Bioeng-092115-025322  0.38
2016 Sammond DW, Kastelowitz N, Himmel ME, Yin H, Crowley MF, Bomble YJ. Comparing Residue Clusters from Thermophilic and Mesophilic Enzymes Reveals Adaptive Mechanisms. Plos One. 11: e0145848. PMID 26741367 DOI: 10.1371/Journal.Pone.0145848  0.709
2016 Yan L, Liang J, Yao C, Wu P, Zeng X, Cheng K, Yin H. Cover Picture: Pyrimidine Triazole Thioether Derivatives as Toll-Like Receptor 5 (TLR5)/Flagellin Complex Inhibitors (ChemMedChem 8/2016) Chemmedchem. 11: 730-730. DOI: 10.1002/Cmdc.201600184  0.514
2015 Wang T, de Jesus AJ, Shi Y, Yin H. Pyridoxamine is a substrate of the energy-coupling factor transporter HmpT. Cell Discovery. 1: 15014. PMID 27462413 DOI: 10.1038/Celldisc.2015.14  0.76
2015 Yan L, Liang J, Yao C, Wu P, Zeng X, Cheng K, Yin H. Pyrimidine Triazole Thioether Derivatives as Toll-Like Receptor 5 (TLR5)/Flagellin Complex Inhibitors. Chemmedchem. PMID 26634412 DOI: 10.1002/Cmdc.201500471  0.573
2015 Wang X, Zhang Y, Peng Y, Hutchinson MR, Rice KC, Yin H, Watkins LR. Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as Toll-like receptor 4 antagonists. British Journal of Pharmacology. PMID 26603732 DOI: 10.1111/Bph.13394  0.534
2015 Yu S, Wang S, Yu H, Feng Y, Zhang S, Zhu M, Yin H, Meng X. A ratiometric two-photon fluorescent probe for hydrazine and its applications. Sensors and Actuators. B, Chemical. 220: 1338-1345. PMID 26500394 DOI: 10.1016/J.Snb.2015.07.051  0.488
2015 Li J, Csakai A, Jin J, Zhang F, Yin H. Therapeutic Developments Targeting Toll-like Receptor-4-Mediated Neuroinflammation. Chemmedchem. PMID 26136385 DOI: 10.1002/Cmdc.201500188  0.391
2015 Cheng K, Gao M, Godfroy JI, Brown PN, Kastelowitz N, Yin H. Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists. Science Advances. 1. PMID 26101787 DOI: 10.1126/Sciadv.1400139  0.522
2015 Selfridge BR, Wang X, Zhang Y, Yin H, Grace PM, Watkins LR, Jacobson AE, Rice KC. Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists. Journal of Medicinal Chemistry. 58: 5038-52. PMID 26010811 DOI: 10.1021/Acs.Jmedchem.5B00426  0.555
2015 Daniele SG, Béraud D, Davenport C, Cheng K, Yin H, Maguire-Zeiss KA. Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders. Science Signaling. 8: ra45. PMID 25969543 DOI: 10.1126/Scisignal.2005965  0.506
2015 Yan L, de Jesus AJ, Tamura R, Li V, Cheng K, Yin H. Curvature sensing MARCKS-ED peptides bind to membranes in a stereo-independent manner. Journal of Peptide Science : An Official Publication of the European Peptide Society. 21: 577-85. PMID 25851418 DOI: 10.1002/Psc.2772  0.81
2015 Wang X, Wang X, Feng Y, Zhu M, Yin H, Guo Q, Meng X. A two-photon fluorescent probe for detecting endogenous hypochlorite in living cells. Dalton Transactions (Cambridge, England : 2003). 44: 6613-9. PMID 25757874 DOI: 10.1039/C5Dt00012B  0.378
2015 Gao M, Cheng K, Yin H. Targeting protein-protein interfaces using macrocyclic peptides. Biopolymers. PMID 25664609 DOI: 10.1002/Bip.22625  0.578
2015 Northcutt AL, Hutchinson MR, Wang X, Baratta MV, Hiranita T, Cochran TA, Pomrenze MB, Galer EL, Kopajtic TA, Li CM, Amat J, Larson G, Cooper DC, Huang Y, O'Neill CE, ... Yin H, et al. DAT isn't all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling. Molecular Psychiatry. PMID 25644383 DOI: 10.1038/Mp.2014.177  0.492
2015 D'Atri LP, Etulain J, Rivadeneyra L, Lapponi MJ, Centurion M, Cheng K, Yin H, Schattner M. Expression and functionality of Toll-like receptor 3 in the megakaryocytic lineage. Journal of Thrombosis and Haemostasis : Jth. 13: 839-50. PMID 25594115 DOI: 10.1111/Jth.12842  0.528
2015 Smith C, Wang X, Yin H. Caspases come together over LPS. Trends in Immunology. 36: 59-61. PMID 25573609 DOI: 10.1016/J.It.2014.12.007  0.394
2015 Yang H, Chen YZ, Zhang Y, Wang X, Zhao X, Godfroy JI, Liang Q, Zhang M, Zhang T, Yuan Q, Ann Royal M, Driscoll M, Xia NS, Yin H, Xue D. A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells. Nature Communications. 6: 5717. PMID 25564762 DOI: 10.1038/Ncomms6717  0.447
2015 Kastelowitz N, Jarvis A, White OR, Brown PN, Brodsky G, Tamura R, Paola JAD, Yin H. MARCKS ED Inhibits Fibrin Formation By Blocking Coagulation Protein Complex Assembly on Phosphatidylserine Blood. 126: 2272-2272. DOI: 10.1182/Blood.V126.23.2272.2272  0.399
2015 Grace P, Wang X, Urban D, Baratta M, Galer E, Strand K, Zhang Y, Yin H, Roth B, Maier S, Watkins L. (250) Selective manipulation of spinal microglia by chemogenetics: implications for allodynia and inflammatory signaling The Journal of Pain. 16: S38. DOI: 10.1016/J.Jpain.2015.01.167  0.433
2015 Kargas VE, Holdbrook DA, Godfroy JI, Yin H, Ford RC, Bond PJ. Sending Innate Immune Signals Across the Membrane: A Multiscale Simulation Approach to Toll-Like Receptor Assembly Biophysical Journal. 108: 99. DOI: 10.1016/J.Bpj.2014.11.567  0.395
2015 Berglund NA, Febbraio MA, Ford RC, Godfroy JI, Holdbrook DA, Kargas VE, Khalid S, Lancaster GI, Yin H, Bond PJ. Establishing the Structural Rules for Ligand Recognition, Signaling and Assembly in Innate Immune Receptors Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.562  0.383
2015 Grace P, Wang X, Urban D, Baratta M, Galer E, Strand K, Zhang Y, Yin H, Roth B, Maier S, Watkins L. Selective manipulation of spinal microglia by chemogenetics: Implications for allodynia and inflammatory signaling Brain, Behavior, and Immunity. 49: e7. DOI: 10.1016/J.Bbi.2015.06.045  0.545
2014 Gao M, London N, Cheng K, Tamura R, Jin J, Schueler-Furman O, Yin H. Rationally Designed Macrocyclic Peptides as Synergistic Agonists of LPS-Induced Inflammatory Response. Tetrahedron. 70: 7664-7668. PMID 25400297 DOI: 10.1016/J.Tet.2014.07.026  0.58
2014 Beninson LA, Brown PN, Loughridge AB, Saludes JP, Maslanik T, Hills AK, Woodworth T, Craig W, Yin H, Fleshner M. Acute stressor exposure modifies plasma exosome-associated heat shock protein 72 (Hsp72) and microRNA (miR-142-5p and miR-203). Plos One. 9: e108748. PMID 25259839 DOI: 10.1371/Journal.Pone.0108748  0.679
2014 Grace PM, Ramos KM, Rodgers KM, Wang X, Hutchinson MR, Lewis MT, Morgan KN, Kroll JL, Taylor FR, Strand KA, Zhang Y, Berkelhammer D, Huey MG, Greene LI, Cochran TA, ... Yin H, et al. Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae. Neuroscience. 280: 299-317. PMID 25241065 DOI: 10.1016/J.Neuroscience.2014.09.020  0.554
2014 Morton LA, Tamura R, de Jesus AJ, Espinoza A, Yin H. Biophysical investigations with MARCKS-ED: dissecting the molecular mechanism of its curvature sensing behaviors. Biochimica Et Biophysica Acta. 1838: 3137-44. PMID 25195712 DOI: 10.1016/J.Bbamem.2014.08.027  0.798
2014 Li Y, Smith C, Wu H, Teng P, Shi Y, Padhee S, Jones T, Nguyen AM, Cao C, Yin H, Cai J. Short antimicrobial lipo-α/γ-AA hybrid peptides. Chembiochem : a European Journal of Chemical Biology. 15: 2275-80. PMID 25169879 DOI: 10.1002/Cbic.201402264  0.497
2014 Kastelowitz N, Yin H. Exosomes and microvesicles: identification and targeting by particle size and lipid chemical probes. Chembiochem : a European Journal of Chemical Biology. 15: 923-8. PMID 24740901 DOI: 10.1002/Cbic.201400043  0.368
2014 Padhee S, Smith C, Wu H, Li Y, Manoj N, Qiao Q, Khan Z, Cao C, Yin H, Cai J. The development of antimicrobial a-AApeptides that suppress proinflammatory immune responses. Chembiochem : a European Journal of Chemical Biology. 15: 688-94. PMID 24677440 DOI: 10.1002/Cbic.201300709  0.478
2014 Li Y, Smith C, Wu H, Padhee S, Manoj N, Cardiello J, Qiao Q, Cao C, Yin H, Cai J. Lipidated cyclic γ-AApeptides display both antimicrobial and anti-inflammatory activity. Acs Chemical Biology. 9: 211-7. PMID 24144063 DOI: 10.1021/Cb4006613  0.519
2014 Beninson L, Campisi J, Brown P, Loughridge A, Saludes J, Hills A, Woodworth T, Craig W, Yin H, Fleshner M. 12. Exposure to acute stress modifies plasma exosomes capable of improving host defense to bacterial challenge Brain, Behavior, and Immunity. 40: e4. DOI: 10.1016/J.Bbi.2014.06.032  0.685
2013 Lluis MW, Yin H. Engineering and utilization of reporter cell lines for cell-based assays of transmembrane receptors. Methods in Molecular Biology (Clifton, N.J.). 1063: 211-25. PMID 23975780 DOI: 10.1007/978-1-62703-583-5_12  0.354
2013 de Jesus AJ, Kastelowitz N, Yin H. Changes in lipid density induce membrane curvature. Rsc Advances. 3: 13622-13625. PMID 23930220 DOI: 10.1039/C3Ra42332H  0.785
2013 Saludes JP, Morton LA, Coulup SK, Fiorini Z, Cook BM, Beninson L, Chapman ER, Fleshner M, Yin H. Multivalency amplifies the selection and affinity of bradykinin-derived peptides for lipid nanovesicles. Molecular Biosystems. 9: 2005-9. PMID 23715428 DOI: 10.1039/C3Mb70109C  0.802
2013 Wang X, Grace PM, Pham MN, Cheng K, Strand KA, Smith C, Li J, Watkins LR, Yin H. Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 2713-22. PMID 23568774 DOI: 10.1096/Fj.12-222992  0.66
2013 Li J, Wang X, Zhang F, Yin H. Toll-like receptors as therapeutic targets for autoimmune connective tissue diseases. Pharmacology & Therapeutics. 138: 441-51. PMID 23531543 DOI: 10.1016/J.Pharmthera.2013.03.003  0.447
2013 Wang X, Smith C, Yin H. Targeting Toll-like receptors with small molecule agents. Chemical Society Reviews. 42: 4859-66. PMID 23503527 DOI: 10.1039/C3Cs60039D  0.449
2013 Lee J, Sammond DW, Fiorini Z, Saludes JP, Resch MG, Hao B, Wang W, Yin H, Liu X. Computationally designed peptide inhibitors of the ubiquitin E3 ligase SCF(Fbx4). Chembiochem : a European Journal of Chemical Biology. 14: 445-51. PMID 23401343 DOI: 10.1002/Cbic.201200777  0.793
2013 Lluis MW, Godfroy JI, Yin H. Protein engineering methods applied to membrane protein targets. Protein Engineering, Design & Selection : Peds. 26: 91-100. PMID 23118339 DOI: 10.1093/Protein/Gzs079  0.365
2013 Morton LA, Yang H, Saludes JP, Fiorini Z, Beninson L, Chapman ER, Fleshner M, Xue D, Yin H. MARCKS-ED peptide as a curvature and lipid sensor. Acs Chemical Biology. 8: 218-25. PMID 23075500 DOI: 10.1021/Cb300429E  0.805
2013 Coulup SK, Morton LA, Yin H. Abstract 2233: MARCKS-ED peptide targets highly curved vesicles: Potential probe for exosome detection. Cancer Research. 73: 2233-2233. DOI: 10.1158/1538-7445.Am2013-2233  0.812
2012 Yin H. Constrained Peptides as Miniature Protein Structures International Scholarly Research Notices. 2012: 692190-692190. PMID 25969758 DOI: 10.5402/2012/692190  0.368
2012 Godfroy JI, Roostan M, Moroz YS, Korendovych IV, Yin H. Isolated Toll-like receptor transmembrane domains are capable of oligomerization. Plos One. 7: e48875. PMID 23155421 DOI: 10.1371/Journal.Pone.0048875  0.664
2012 Wang X, Fiorini Z, Smith C, Zhang Y, Li J, Watkins LR, Yin H. Repositioning antimicrobial agent pentamidine as a disruptor of the lateral interactions of transmembrane domain 5 of EBV latent membrane protein 1. Plos One. 7: e47703. PMID 23094078 DOI: 10.1371/Journal.Pone.0047703  0.599
2012 Zhang S, Cheng K, Wang X, Yin H. Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors. Bioorganic & Medicinal Chemistry. 20: 6073-9. PMID 22985959 DOI: 10.1016/J.Bmc.2012.08.022  0.677
2012 Cheng K, Wang X, Zhang S, Yin H. Discovery of small-molecule inhibitors of the TLR1/TLR2 complex. Angewandte Chemie (International Ed. in English). 51: 12246-9. PMID 22969053 DOI: 10.1002/Anie.201204910  0.687
2012 Due MR, Piekarz AD, Wilson N, Feldman P, Ripsch MS, Chavez S, Yin H, Khanna R, White FA. Neuroexcitatory effects of morphine-3-glucuronide are dependent on Toll-like receptor 4 signaling. Journal of Neuroinflammation. 9: 200. PMID 22898544 DOI: 10.1186/1742-2094-9-200  0.301
2012 Hutchinson MR, Northcutt AL, Hiranita T, Wang X, Lewis SS, Thomas J, van Steeg K, Kopajtic TA, Loram LC, Sfregola C, Galer E, Miles NE, Bland ST, Amat J, Rozeske RR, ... ... Yin H, et al. Opioid activation of toll-like receptor 4 contributes to drug reinforcement. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11187-200. PMID 22895704 DOI: 10.1523/Jneurosci.0684-12.2012  0.535
2012 Miyauchi K, Urano E, Takeda S, Murakami T, Okada Y, Cheng K, Yin H, Kubo M, Komano J. Toll-like receptor (TLR) 3 as a surrogate sensor of retroviral infection in human cells. Biochemical and Biophysical Research Communications. 424: 519-23. PMID 22771581 DOI: 10.1016/J.Bbrc.2012.06.148  0.521
2012 Saludes JP, Morton LA, Ghosh N, Beninson LA, Chapman ER, Fleshner M, Yin H. Detection of highly curved membrane surfaces using a cyclic peptide derived from synaptotagmin-I. Acs Chemical Biology. 7: 1629-35. PMID 22769435 DOI: 10.1021/Cb3002705  0.802
2012 Morton LA, Saludes JP, Yin H. Constant pressure-controlled extrusion method for the preparation of Nano-sized lipid vesicles. Journal of Visualized Experiments : Jove. PMID 22760481 DOI: 10.3791/4151  0.78
2012 Wang X, Saludes JP, Zhao TX, Csakai A, Fiorini Z, Chavez SA, Li J, Lee GI, Varga K, Yin H. Targeting the lateral interactions of transmembrane domain 5 of Epstein-Barr virus latent membrane protein 1. Biochimica Et Biophysica Acta. 1818: 2282-9. PMID 22609737 DOI: 10.1016/J.Bbamem.2012.05.013  0.741
2012 Wang X, Loram LC, Ramos K, de Jesus AJ, Thomas J, Cheng K, Reddy A, Somogyi AA, Hutchinson MR, Watkins LR, Yin H. Morphine activates neuroinflammation in a manner parallel to endotoxin. Proceedings of the National Academy of Sciences of the United States of America. 109: 6325-30. PMID 22474354 DOI: 10.1073/Pnas.1200130109  0.77
2012 Lee G, Sammond DW, Joce C, Takeshita R, McQuate SE, Ghosh N, Martin JM, Wang X, Zhao TX, Saludes JP, Csakai A, Fiorini Z, Chavez SA, Li J, Varga K, ... Yin H, et al. Investigation of homo-oligomeric interface and binding hotspot of Latent membrane protein-1 (LMP-1) of Epstein-Barr virus (EBV) Rapid Communication in Photoscience. 1: 58-58. DOI: 10.5857/Rcp.2012.1.2.058  0.779
2012 Coulup SK, Saludes JP, Yin H. Abstract 4745: Multivalent dendrimeric peptides as new biomarker probes for the detection of cancer metastasis Cancer Research. 72: 4745-4745. DOI: 10.1158/1538-7445.Am2012-4745  0.735
2012 Saludes J, Morton L, Ghosh N, Beninson L, Chapman E, Fleshner M, Yin H. Abstract 4743: Exosomes in motion: Visualizing cancer metastasis via the Synaptotagmin C2B domain Cancer Research. 72: 4743-4743. DOI: 10.1158/1538-7445.Am2012-4743  0.789
2012 Cheng K, Wang X, Zhang S, Yin H. Inside Back Cover: Discovery of Small‐Molecule Inhibitors of the TLR1/TLR2 Complex (Angew. Chem. Int. Ed. 49/2012) Angewandte Chemie. 51: 12375-12375. DOI: 10.1002/Anie.201208674  0.663
2012 Cheng K, Wang X, Zhang S, Yin H. Innenrücktitelbild: Discovery of Small-Molecule Inhibitors of the TLR1/TLR2 Complex (Angew. Chem. 49/2012) Angewandte Chemie. 124: 12543-12543. DOI: 10.1002/Ange.201208674  0.664
2011 Joce C, Wiener AA, Yin H. Multi-Tox: application of the ToxR-transcriptional reporter assay to the study of multi-pass protein transmembrane domain oligomerization. Biochimica Et Biophysica Acta. 1808: 2948-53. PMID 21791200 DOI: 10.1016/J.Bbamem.2011.07.008  0.366
2011 Liu L, Ghosh N, Slivka PF, Fiorini Z, Hutchinson MR, Watkins LR, Yin H. An MD2 hot-spot-mimicking peptide that suppresses TLR4-mediated inflammatory response in vitro and in vivo. Chembiochem : a European Journal of Chemical Biology. 12: 1827-31. PMID 21678541 DOI: 10.1002/Cbic.201100211  0.681
2011 Joce C, Wiener A, Yin H. Transmembrane domain oligomerization propensity determined by ToxR assay. Journal of Visualized Experiments. PMID 21654625 DOI: 10.3791/2721  0.418
2011 Chavez SA, Martinko AJ, Lau C, Pham MN, Cheng K, Bevan DE, Mollnes TE, Yin H. Development of β-amino alcohol derivatives that inhibit Toll-like receptor 4 mediated inflammatory response as potential antiseptics. Journal of Medicinal Chemistry. 54: 4659-69. PMID 21591694 DOI: 10.1021/Jm2003365  0.533
2011 Sammond DW, Joce C, Takeshita R, McQuate SE, Ghosh N, Martin JM, Yin H. Transmembrane peptides used to investigate the homo-oligomeric interface and binding hotspot of latent membrane protein 1. Biopolymers. 95: 772-84. PMID 21560118 DOI: 10.1002/Bip.21672  0.801
2011 Cheng K, Wang X, Yin H. Small-molecule inhibitors of the TLR3/dsRNA complex. Journal of the American Chemical Society. 133: 3764-7. PMID 21355588 DOI: 10.1021/Ja111312H  0.597
2011 Kazi A, Sun J, Doi K, Sung SS, Takahashi Y, Yin H, Rodriguez JM, Becerril J, Berndt N, Hamilton AD, Wang HG, Sebti SM. The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner. The Journal of Biological Chemistry. 286: 9382-92. PMID 21148306 DOI: 10.1074/Jbc.M110.203638  0.761
2011 Yin H. Abstract LB-242: Dissecting Cell Signaling Mediated by Multi-spanning Transmembrane Domain Association Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-242  0.411
2011 Liu L, Ghosh N, Slivka PF, Fiorini Z, Hutchinson MR, Watkins LR, Yin H. Inside Cover: An MD2 Hot-Spot-Mimicking Peptide that Suppresses TLR4-Mediated Inflammatory Response in vitro and in vivo (ChemBioChem 12/2011) Chembiochem. 12: 1786-1786. DOI: 10.1002/Cbic.201190054  0.659
2010 Bevan DE, Martinko AJ, Loram LC, Stahl JA, Taylor FR, Joshee S, Watkins LR, Yin H. Selection, Preparation, and Evaluation of Small- Molecule Inhibitors of Toll-Like Receptor 4. Acs Medicinal Chemistry Letters. 1: 194-198. PMID 20824192 DOI: 10.1021/Ml100041F  0.546
2010 Joce C, Stahl JA, Shridhar M, Hutchinson MR, Watkins LR, Fedichev PO, Yin H. Application of a novel in silico high-throughput screen to identify selective inhibitors for protein-protein interactions. Bioorganic & Medicinal Chemistry Letters. 20: 5411-3. PMID 20709548 DOI: 10.1016/J.Bmcl.2010.07.103  0.493
2010 Yin H, Gao L, Shen B, Chao L, Chao J. Kallistatin inhibits vascular inflammation by antagonizing tumor necrosis factor-alpha-induced nuclear factor kappaB activation. Hypertension. 56: 260-7. PMID 20566960 DOI: 10.1161/Hypertensionaha.110.152330  0.302
2010 Buchanan MM, Hutchinson M, Watkins LR, Yin H. Toll-like receptor 4 in CNS pathologies. Journal of Neurochemistry. 114: 13-27. PMID 20402965 DOI: 10.1111/J.1471-4159.2010.06736.X  0.474
2010 Hutchinson MR, Loram LC, Zhang Y, Shridhar M, Rezvani N, Berkelhammer D, Phipps S, Foster PS, Landgraf K, Falke JJ, Rice KC, Maier SF, Yin H, Watkins LR. Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity. Neuroscience. 168: 551-63. PMID 20381591 DOI: 10.1016/J.Neuroscience.2010.03.067  0.514
2010 Hutchinson MR, Lewis SS, Coats BD, Rezvani N, Zhang Y, Wieseler JL, Somogyi AA, Yin H, Maier SF, Rice KC, Watkins LR. Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences. Neuroscience. 167: 880-93. PMID 20178837 DOI: 10.1016/J.Neuroscience.2010.02.011  0.48
2010 Zhao TX, Martinko AJ, Le VH, Zhao J, Yin H. Development of agents that modulate protein-protein interactions in membranes. Current Pharmaceutical Design. 16: 1055-62. PMID 20030619 DOI: 10.2174/138161210790963878  0.371
2010 Hutchinson MR, Zhang Y, Shridhar M, Evans JH, Buchanan MM, Zhao TX, Slivka PF, Coats BD, Rezvani N, Wieseler J, Hughes TS, Landgraf KE, Chan S, Fong S, Phipps S, ... ... Yin H, et al. Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain, Behavior, and Immunity. 24: 83-95. PMID 19679181 DOI: 10.1016/J.Bbi.2009.08.004  0.465
2009 Tang J, Yin H, Qiu J, Tucker MJ, DeGrado WF, Gai F. Using two fluorescent probes to dissect the binding, insertion, and dimerization kinetics of a model membrane peptide. Journal of the American Chemical Society. 131: 3816-7. PMID 19256494 DOI: 10.1021/Ja809007F  0.558
2009 Slivka PF, Shridhar M, Lee GI, Sammond DW, Hutchinson MR, Martinko AJ, Buchanan MM, Sholar PW, Kearney JJ, Harrison JA, Watkins LR, Yin H. A peptide antagonist of the TLR4-MD2 interaction. Chembiochem : a European Journal of Chemical Biology. 10: 645-9. PMID 19184989 DOI: 10.1002/Cbic.200800769  0.784
2008 Li Y, Chase AR, Slivka PF, Baggett CT, Zhao TX, Yin H. Design, synthesis, and evaluation of biotinylated opioid derivatives as novel probes to study opioid pharmacology. Bioconjugate Chemistry. 19: 2585-9. PMID 19090701 DOI: 10.1021/Bc8003815  0.3
2008 Caputo GA, Litvinov RI, Li W, Bennett JS, Degrado WF, Yin H. Computationally designed peptide inhibitors of protein-protein interactions in membranes. Biochemistry. 47: 8600-6. PMID 18642886 DOI: 10.1021/Bi800687H  0.728
2008 Slivka PF, Wong J, Caputo GA, Yin H. Peptide probes for protein transmembrane domains. Acs Chemical Biology. 3: 402-11. PMID 18533658 DOI: 10.1021/Cb800049W  0.691
2008 Yin H. Exogenous agents that target transmembrane domains of proteins Angewandte Chemie - International Edition. 47: 2744-2752. PMID 18318029 DOI: 10.1002/Anie.200704780  0.362
2007 White TC, Berny MA, Robinson DK, Yin H, DeGrado WF, Hanson SR, McCarty OJ. The leech product saratin is a potent inhibitor of platelet integrin alpha2beta1 and von Willebrand factor binding to collagen. The Febs Journal. 274: 1481-91. PMID 17489103 DOI: 10.1111/J.1742-4658.2007.05689.X  0.457
2007 Yin H, Slusky JS, Berger BW, Walters RS, Vilaire G, Litvinov RI, Lear JD, Caputo GA, Bennett JS, DeGrado WF. Computational design of peptides that target transmembrane helices. Science (New York, N.Y.). 315: 1817-22. PMID 17395823 DOI: 10.1126/Science.1136782  0.795
2007 White T, Berny M, Robinson D, Yin H, DeGrado W, Hanson S, McCarty O. THE LEECH PRODUCT SARATIN IS A POTENT INHIBITOR OF PLATELET INTEGRIN ALPHA2BETA1 AND VWF BINDING TO COLLAGEN Journal of Thrombosis and Haemostasis. 5: P-M-347-P-M-347. DOI: 10.1111/J.1538-7836.2007.Tb01268.X  0.445
2006 Yin H, Litvinov RI, Vilaire G, Zhu H, Li W, Caputo GA, Moore DT, Lear JD, Weisel JW, Degrado WF, Bennett JS. Activation of platelet alphaIIbbeta3 by an exogenous peptide corresponding to the transmembrane domain of alphaIIb. The Journal of Biological Chemistry. 281: 36732-41. PMID 17032655 DOI: 10.1074/Jbc.M605877200  0.713
2006 Yin H, Gerlach LO, Miller MW, Moore DT, Liu D, Vilaire G, Bennett JS, DeGrado WF. Arylamide derivatives as allosteric inhibitors of the integrin alpha2beta1/type I collagen interaction. Bioorganic & Medicinal Chemistry Letters. 16: 3380-2. PMID 16678410 DOI: 10.1016/J.Bmcl.2006.04.037  0.628
2006 Yin H, Frederick KK, Liu D, Wand AJ, Degrado WF. Arylamide derivatives as peptidomimetic inhibitors of calmodulin. Organic Letters. 8: 223-5. PMID 16408880 DOI: 10.1021/Ol052478J  0.526
2006 White TC, Robinson DK, Yin H, DeGrado WF, Hanson SR, McCarty OJT. The Leech Product Saratin Is a Potent Inhibitor of Both VWF and Integrin α2β1 Binding to Collagen. Blood. 108: 3928-3928. DOI: 10.1182/Blood.V108.11.3928.3928  0.458
2006 Yin H, Slusky JS, Berger BW, Litvinov RI, Vilaire G, Lear JD, DeGrado WF, Bennett JS. Regulation of the Function of αvβ3 in Platelets by a Designed Peptide Targeting the αv Transmembrane Domain. Blood. 108: 1504-1504. DOI: 10.1182/Blood.V108.11.1504.1504  0.802
2005 Yin H, Lee GI, Sedey KA, Kutzki O, Park HS, Orner BP, Ernst JT, Wang HG, Sebti SM, Hamilton AD. Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL. Journal of the American Chemical Society. 127: 10191-6. PMID 16028929 DOI: 10.1021/Ja050122X  0.782
2005 Chen L, Yin H, Farooqi B, Sebti S, Hamilton AD, Chen J. p53 alpha-Helix mimetics antagonize p53/MDM2 interaction and activate p53. Molecular Cancer Therapeutics. 4: 1019-25. PMID 15956260 DOI: 10.1158/1535-7163.Mct-04-0342  0.478
2005 Yin H, Hamilton AD. Strategies for targeting protein-protein interactions with synthetic agents. Angewandte Chemie (International Ed. in English). 44: 4130-63. PMID 15954154 DOI: 10.1002/Anie.200461786  0.499
2005 Yin H, Lee GI, Sedey KA, Rodriguez JM, Wang HG, Sebti SM, Hamilton AD. Terephthalamide derivatives as mimetics of helical peptides: disruption of the Bcl-x(L)/Bak interaction. Journal of the American Chemical Society. 127: 5463-8. PMID 15826183 DOI: 10.1021/Ja0446404  0.689
2005 Yin H, Lee GI, Park HS, Payne GA, Rodriguez JM, Sebti SM, Hamilton AD. Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction. Angewandte Chemie (International Ed. in English). 44: 2704-7. PMID 15765497 DOI: 10.1002/Anie.200462316  0.646
2005 Yin H, Zhu H, Vilaire G, Li W, Litvinov RI, DeGrado WF, Bennett JS. Activation of Platelet α Iibβ 3 by Exogenous Peptides Corresponding to the Transmembrane Domains of α Iib and β 3. Blood. 106: 384-384. DOI: 10.1182/Blood.V106.11.384.384  0.494
2005 Yin H, Hamilton AD. Strategien zur Modulation von Protein-Protein-Wechselwirkungen mit synthetischen Substanzen Angewandte Chemie. 117: 4200-4235. DOI: 10.1002/Ange.200461786  0.458
2004 Yin H, Hamilton AD. Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein. Bioorganic & Medicinal Chemistry Letters. 14: 1375-9. PMID 15006365 DOI: 10.1016/J.Bmcl.2003.09.096  0.539
2003 Ernst JT, Becerril J, Park HS, Yin H, Hamilton AD. Design and application of an alpha-helix-mimetic scaffold based on an oligoamide-foldamer strategy: antagonism of the Bak BH3/Bcl-xL complex. Angewandte Chemie (International Ed. in English). 42: 535-9. PMID 12569483 DOI: 10.1002/Anie.200390154  0.762
2002 Kutzki O, Park HS, Ernst JT, Orner BP, Yin H, Hamilton AD. Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry. Journal of the American Chemical Society. 124: 11838-9. PMID 12358513 DOI: 10.1021/Ja026861K  0.793
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