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Ralph A. Cacho - Publications

Affiliations: 
University of Washington, Seattle, Seattle, WA 
Area:
biochemistry, protein design, enzymology, natural product biosynthesis
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16 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Grandner JM, Cacho RA, Tang Y, Houk KN. Mechanism of the P450-Catalyzed Oxidative Cyclization in the Biosynthesis of Griseofulvin. Acs Catalysis. 6: 4506-4511. PMID 28503354 DOI: 10.1021/acscatal.6b01068  0.383
2016 Zhang J, Liu N, Cacho RA, Gong Z, Liu Z, Qin W, Tang C, Tang Y, Zhou J. Structural basis of nonribosomal peptide macrocyclization in fungi. Nature Chemical Biology. PMID 27748753 DOI: 10.1038/Nchembio.2202  0.334
2016 Cacho RA, Tang Y. Reconstitution of Fungal Nonribosomal Peptide Synthetases in Yeast and In Vitro. Methods in Molecular Biology (Clifton, N.J.). 1401: 103-19. PMID 26831704 DOI: 10.1007/978-1-4939-3375-4_7  0.395
2015 Cacho RA, Thuss J, Xu W, Sanichar R, Gao Z, Nguyen A, Vederas JC, Tang Y. Understanding Programming of Fungal Iterative Polyketide Synthases: the Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin Megasynthase. Journal of the American Chemical Society. PMID 26630357 DOI: 10.1021/Jacs.5B11814  0.337
2015 Tang MC, Lin HC, Li D, Zou Y, Li J, Xu W, Cacho RA, Hillenmeyer ME, Garg NK, Tang Y. Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast. Journal of the American Chemical Society. PMID 26469304 DOI: 10.1021/Jacs.5B06108  0.465
2015 Zou Y, Zhan Z, Li D, Tang M, Cacho RA, Watanabe K, Tang Y. Tandem prenyltransferases catalyze isoprenoid elongation and complexity generation in biosynthesis of quinolone alkaloids. Journal of the American Chemical Society. 137: 4980-3. PMID 25859931 DOI: 10.1021/Jacs.5B03022  0.444
2014 Cacho RA, Tang Y, Chooi YH. Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi. Frontiers in Microbiology. 5: 774. PMID 25642215 DOI: 10.3389/Fmicb.2014.00774  0.631
2013 Chooi YH, Hong YJ, Cacho RA, Tantillo DJ, Tang Y. A cytochrome P450 serves as an unexpected terpene cyclase during fungal meroterpenoid biosynthesis. Journal of the American Chemical Society. 135: 16805-8. PMID 24161266 DOI: 10.1021/Ja408966T  0.654
2013 Cacho RA, Chooi YH, Zhou H, Tang Y. Complexity generation in fungal polyketide biosynthesis: a spirocycle-forming P450 in the concise pathway to the antifungal drug griseofulvin. Acs Chemical Biology. 8: 2322-30. PMID 23978092 DOI: 10.1021/Cb400541Z  0.68
2013 Yin WB, Chooi YH, Smith AR, Cacho RA, Hu Y, White TC, Tang Y. Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in Aspergillus nidulans. Acs Synthetic Biology. 2: 629-34. PMID 23758576 DOI: 10.1021/Sb400048B  0.633
2013 Jiang W, Cacho RA, Chiou G, Garg NK, Tang Y, Walsh CT. EcdGHK are three tailoring iron oxygenases for amino acid building blocks of the echinocandin scaffold. Journal of the American Chemical Society. 135: 4457-66. PMID 23451921 DOI: 10.1021/Ja312572V  0.379
2013 Cacho RA, Tang Y. Bringing protein engineering and natural product biosynthesis together. Chemistry & Biology. 20: 3-5. PMID 23352133 DOI: 10.1016/j.chembiol.2013.01.005  0.451
2012 Cacho RA, Jiang W, Chooi YH, Walsh CT, Tang Y. Identification and characterization of the echinocandin B biosynthetic gene cluster from Emericella rugulosa NRRL 11440. Journal of the American Chemical Society. 134: 16781-90. PMID 22998630 DOI: 10.1021/Ja307220Z  0.641
2012 Zabala AO, Cacho RA, Tang Y. Protein engineering towards natural product synthesis and diversification. Journal of Industrial Microbiology & Biotechnology. 39: 227-41. PMID 22006344 DOI: 10.1007/S10295-011-1044-2  0.563
2010 Chooi YH, Cacho R, Tang Y. Identification of the viridicatumtoxin and griseofulvin gene clusters from Penicillium aethiopicum. Chemistry & Biology. 17: 483-94. PMID 20534346 DOI: 10.1016/J.Chembiol.2010.03.015  0.643
2009 Gao X, Xie X, Pashkov I, Sawaya MR, Laidman J, Zhang W, Cacho R, Yeates TO, Tang Y. Directed evolution and structural characterization of a simvastatin synthase. Chemistry & Biology. 16: 1064-74. PMID 19875080 DOI: 10.1016/J.Chembiol.2009.09.017  0.623
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