| Year |
Citation |
Score |
| 2020 |
Kaira BG, Slater A, McCrae KR, Dreveny I, Sumya U, Mutch NJ, Searle M, Emsley J. Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery. Blood. PMID 32559765 DOI: 10.1182/Blood.2020004818 |
0.408 |
|
| 2020 |
Ciszewski L, Lu-Nguyen N, Slater A, Brennan A, Williams HEL, Dickson G, Searle MS, Popplewell L. G-quadruplex ligands mediate downregulation of DUX4 expression. Nucleic Acids Research. PMID 32182342 DOI: 10.1093/Nar/Gkaa146 |
0.313 |
|
| 2019 |
Morgan J, Saleem M, Ng R, Armstrong C, Wong SS, Caulton SG, Fickling A, Williams HEL, Munday AD, López JA, Searle MS, Emsley J. Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib. Blood Advances. 3: 1450-1459. PMID 31053572 DOI: 10.1182/Bloodadvances.2018027011 |
0.387 |
|
| 2018 |
Martin E, Williams HEL, Pitoulias M, Stevens D, Winterhalter C, Craggs TD, Murray H, Searle MS, Soultanas P. DNA replication initiation in Bacillus subtilis: structural and functional characterization of the essential DnaA-DnaD interaction. Nucleic Acids Research. PMID 30534966 DOI: 10.1093/Nar/Gky1220 |
0.397 |
|
| 2016 |
Scott D, Strachan J, Krishna VG, Shaw B, Tooth DJ, Searle MS, Oldham NJ, Layfield R. Method for the Purification of Endogenous Unanchored Polyubiquitin Chains. Methods in Molecular Biology (Clifton, N.J.). 1449: 203-13. PMID 27613037 DOI: 10.1007/978-1-4939-3756-1_11 |
0.307 |
|
| 2016 |
Goode A, Rea S, Sultana M, Shaw B, Searle MS, Layfield R. ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling. Molecular and Cellular Neurosciences. PMID 27554286 DOI: 10.1016/J.Mcn.2016.08.004 |
0.321 |
|
| 2016 |
Goode A, Butler K, Long J, Cavey J, Scott D, Shaw B, Sollenberger J, Gell C, Johansen T, Oldham NJ, Searle MS, Layfield R. Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD. Autophagy. 1-11. PMID 27158844 DOI: 10.1080/15548627.2016.1170257 |
0.325 |
|
| 2016 |
Scott D, Garner TP, Long J, Strachan J, Mistry SC, Bottrill AR, Tooth DJ, Searle MS, Oldham NJ, Layfield R. Mass spectrometry insights into a tandem ubiquitin-binding domain hybrid engineered for the selective recognition of unanchored polyubiquitin. Proteomics. PMID 27037516 DOI: 10.1002/Pmic.201600067 |
0.351 |
|
| 2015 |
Kralovicova J, Patel A, Searle M, Vorechovsky I. The role of short RNA loops in recognition of a single-hairpin exon derived from a mammalian-wide interspersed repeat. Rna Biology. 12: 54-69. PMID 25826413 DOI: 10.1080/15476286.2015.1017207 |
0.305 |
|
| 2015 |
Scott D, Oldham NJ, Strachan J, Searle MS, Layfield R. Ubiquitin-binding domains: mechanisms of ubiquitin recognition and use as tools to investigate ubiquitin-modified proteomes. Proteomics. 15: 844-61. PMID 25327553 DOI: 10.1002/Pmic.201400341 |
0.355 |
|
| 2014 |
Cousins AR, Ritson D, Sharma P, Stevens MF, Moses JE, Searle MS. Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences. Chemical Communications (Cambridge, England). 50: 15202-5. PMID 25338751 DOI: 10.1039/C4Cc07487D |
0.356 |
|
| 2014 |
Smith LD, Dickinson RL, Lucas CM, Cousins A, Malygin AA, Weldon C, Perrett AJ, Bottrill AR, Searle MS, Burley GA, Eperon IC. A targeted oligonucleotide enhancer of SMN2 exon 7 splicing forms competing quadruplex and protein complexes in functional conditions. Cell Reports. 9: 193-205. PMID 25263560 DOI: 10.1016/J.Celrep.2014.08.051 |
0.346 |
|
| 2014 |
Kralovicova J, Lages A, Patel A, Dhir A, Buratti E, Searle M, Vorechovsky I. Optimal antisense target reducing INS intron 1 retention is adjacent to a parallel G quadruplex. Nucleic Acids Research. 42: 8161-73. PMID 24944197 DOI: 10.1093/Nar/Gku507 |
0.331 |
|
| 2014 |
Portman KL, Long J, Carr S, Briand L, Winzor DJ, Searle MS, Scott DJ. Enthalpy/entropy compensation effects from cavity desolvation underpin broad ligand binding selectivity for rat odorant binding protein 3. Biochemistry. 53: 2371-9. PMID 24665925 DOI: 10.1021/Bi5002344 |
0.364 |
|
| 2014 |
Goode A, Long JE, Shaw B, Ralston SH, Visconti MR, Gianfrancesco F, Esposito T, Gennari L, Merlotti D, Rendina D, Rea SL, Sultana M, Searle MS, Layfield R. Paget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and function. Biochimica Et Biophysica Acta. 1842: 992-1000. PMID 24642144 DOI: 10.1016/J.Bbadis.2014.03.006 |
0.381 |
|
| 2013 |
Iachettini S, Stevens MF, Frigerio M, Hummersone MG, Hutchinson I, Garner TP, Searle MS, Wilson DW, Munde M, Nanjunda R, D'Angelo C, Zizza P, Rizzo A, Cingolani C, De Cicco F, et al. On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts. Journal of Experimental & Clinical Cancer Research : Cr. 32: 68. PMID 24330541 DOI: 10.1186/1756-9966-32-68 |
0.325 |
|
| 2013 |
Morris ER, Hall G, Li C, Heeb S, Kulkarni RV, Lovelock L, Silistre H, Messina M, Cámara M, Emsley J, Williams P, Searle MS. Structural rearrangement in an RsmA/CsrA ortholog of Pseudomonas aeruginosa creates a dimeric RNA-binding protein, RsmN. Structure (London, England : 1993). 21: 1659-71. PMID 23954502 DOI: 10.1016/J.Str.2013.07.007 |
0.401 |
|
| 2013 |
Edwards JM, Long J, de Moor CH, Emsley J, Searle MS. Structural insights into the targeting of mRNA GU-rich elements by the three RRMs of CELF1. Nucleic Acids Research. 41: 7153-66. PMID 23748565 DOI: 10.1093/Nar/Gkt470 |
0.343 |
|
| 2013 |
Wright T, Rea SL, Goode A, Bennett AJ, Ratajczak T, Long JE, Searle MS, Goldring CE, Park BK, Copple IM, Layfield R. The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone. Bone. 52: 699-706. PMID 23117207 DOI: 10.1016/J.Bone.2012.10.023 |
0.322 |
|
| 2012 |
Morris ER, Searle MS. Overview of protein folding mechanisms: experimental and theoretical approaches to probing energy landscapes. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 28.2.1-22. PMID 22470128 DOI: 10.1002/0471140864.Ps2802S68 |
0.328 |
|
| 2012 |
Searle MS, Garner TP, Strachan J, Long J, Adlington J, Cavey JR, Shaw B, Layfield R. Structural insights into specificity and diversity in mechanisms of ubiquitin recognition by ubiquitin-binding domains. Biochemical Society Transactions. 40: 404-8. PMID 22435820 DOI: 10.1042/Bst20110729 |
0.395 |
|
| 2012 |
Sokratous K, Roach LV, Channing D, Strachan J, Long J, Searle MS, Layfield R, Oldham NJ. Probing affinity and ubiquitin linkage selectivity of ubiquitin-binding domains using mass spectrometry. Journal of the American Chemical Society. 134: 6416-24. PMID 22428841 DOI: 10.1021/Ja300749D |
0.397 |
|
| 2011 |
Garner TP, Strachan J, Shedden EC, Long JE, Cavey JR, Shaw B, Layfield R, Searle MS. Independent interactions of ubiquitin-binding domains in a ubiquitin-mediated ternary complex. Biochemistry. 50: 9076-87. PMID 21923101 DOI: 10.1021/Bi201137E |
0.389 |
|
| 2011 |
Boh BK, Ng MY, Leck YC, Shaw B, Long J, Sun GW, Gan YH, Searle MS, Layfield R, Hagen T. Inhibition of cullin RING ligases by cycle inhibiting factor: evidence for interference with Nedd8-induced conformational control. Journal of Molecular Biology. 413: 430-7. PMID 21903097 DOI: 10.1016/J.Jmb.2011.08.030 |
0.369 |
|
| 2011 |
Edwards J, Malaurie E, Kondrashov A, Long J, de Moor CH, Searle MS, Emsley J. Sequence determinants for the tandem recognition of UGU and CUG rich RNA elements by the two N--terminal RRMs of CELF1. Nucleic Acids Research. 39: 8638-50. PMID 21743084 DOI: 10.1093/Nar/Gkr510 |
0.373 |
|
| 2011 |
Garner TP, Long J, Layfield R, Searle MS. Impact of p62/SQSTM1 UBA domain mutations linked to Paget's disease of bone on ubiquitin recognition. Biochemistry. 50: 4665-74. PMID 21517082 DOI: 10.1021/Bi200079N |
0.399 |
|
| 2011 |
Linder J, Garner TP, Williams HE, Searle MS, Moody CJ. Telomestatin: formal total synthesis and cation-mediated interaction of its seco-derivatives with G-quadruplexes. Journal of the American Chemical Society. 133: 1044-51. PMID 21162526 DOI: 10.1021/Ja109158K |
0.359 |
|
| 2011 |
Chen P, Evans CL, Hirst JD, Searle MS. Structural insights into the two sequential folding transition states of the PB1 domain of NBR1 from Φ value analysis and biased molecular dynamics simulations. Biochemistry. 50: 125-35. PMID 21121670 DOI: 10.1021/Bi1016793 |
0.577 |
|
| 2010 |
Derecka K, Balkwill GD, Garner TP, Hodgman C, Flint AP, Searle MS. Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1). Biochemistry. 49: 7625-33. PMID 20715834 DOI: 10.1021/Bi100804F |
0.33 |
|
| 2010 |
Heinen C, Garner TP, Long J, Böttcher C, Ralston SH, Cavey JR, Searle MS, Layfield R, Dantuma NP. Mutant p62/SQSTM1 UBA domains linked to Paget's disease of bone differ in their abilities to function as stabilization signals. Febs Letters. 584: 1585-90. PMID 20230821 DOI: 10.1016/J.Febslet.2010.03.018 |
0.347 |
|
| 2010 |
Long J, Garner TP, Pandya MJ, Craven CJ, Chen P, Shaw B, Williamson MP, Layfield R, Searle MS. Dimerisation of the UBA domain of p62 inhibits ubiquitin binding and regulates NF-kappaB signalling. Journal of Molecular Biology. 396: 178-94. PMID 19931284 DOI: 10.1016/J.Jmb.2009.11.032 |
0.386 |
|
| 2009 |
Balkwill GD, Derecka K, Garner TP, Hodgman C, Flint AP, Searle MS. Repression of translation of human estrogen receptor alpha by G-quadruplex formation. Biochemistry. 48: 11487-95. PMID 19860473 DOI: 10.1021/Bi901420K |
0.305 |
|
| 2009 |
Garner TP, Williams HE, Gluszyk KI, Roe S, Oldham NJ, Stevens MF, Moses JE, Searle MS. Selectivity of small molecule ligands for parallel and anti-parallel DNA G-quadruplex structures. Organic & Biomolecular Chemistry. 7: 4194-200. PMID 19795057 DOI: 10.1039/B910505K |
0.413 |
|
| 2009 |
Rea AM, Thurston V, Searle MS. Mechanism of ligand-induced folding of a natively unfolded helixless variant of rabbit I-BABP. Biochemistry. 48: 7556-64. PMID 19580252 DOI: 10.1021/Bi900805S |
0.422 |
|
| 2009 |
Balkwill GD, Garner TP, Searle MS. Folding of single-stranded DNA quadruplexes containing an autonomously stable mini-hairpin loop. Molecular Biosystems. 5: 542-7. PMID 19381368 DOI: 10.1039/B900540D |
0.311 |
|
| 2009 |
Balkwill GD, Garner TP, Williams HE, Searle MS. Folding topology of a bimolecular DNA quadruplex containing a stable mini-hairpin motif within the diagonal loop. Journal of Molecular Biology. 385: 1600-15. PMID 19070621 DOI: 10.1016/J.Jmb.2008.11.050 |
0.38 |
|
| 2009 |
Najat D, Garner T, Hagen T, Shaw B, Sheppard PW, Falchetti A, Marini F, Brandi ML, Long JE, Cavey JR, Searle MS, Layfield R. Characterization of a non-UBA domain missense mutation of sequestosome 1 (SQSTM1) in Paget's disease of bone. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 24: 632-42. PMID 19049332 DOI: 10.1359/Jbmr.081204 |
0.368 |
|
| 2008 |
Rea AM, Simpson ER, Meldrum JK, Williams HE, Searle MS. Aromatic residues engineered into the beta-turn nucleation site of ubiquitin lead to a complex folding landscape, non-native side-chain interactions, and kinetic traps. Biochemistry. 47: 12910-22. PMID 18991391 DOI: 10.1021/Bi801330R |
0.396 |
|
| 2008 |
Rea AM, Simpson ER, Crespo MD, Searle MS. Helix mutations stabilize a late productive intermediate on the folding pathway of ubiquitin. Biochemistry. 47: 8225-36. PMID 18616284 DOI: 10.1021/Bi800722D |
0.366 |
|
| 2008 |
Layfield R, Searle MS. Disruption of ubiquitin-mediated processes in diseases of the brain and bone. Biochemical Society Transactions. 36: 469-71. PMID 18481983 DOI: 10.1042/Bst0360469 |
0.341 |
|
| 2008 |
Delahay RM, Balkwill GD, Bunting KA, Edwards W, Atherton JC, Searle MS. The highly repetitive region of the Helicobacter pylori CagY protein comprises tandem arrays of an alpha-helical repeat module. Journal of Molecular Biology. 377: 956-71. PMID 18295231 DOI: 10.1016/J.Jmb.2008.01.053 |
0.345 |
|
| 2008 |
Chen P, Long J, Searle MS. Sequential barriers and an obligatory metastable intermediate define the apparent two-state folding pathway of the ubiquitin-like PB1 domain of NBR1. Journal of Molecular Biology. 376: 1463-77. PMID 18234223 DOI: 10.1016/J.Jmb.2007.12.052 |
0.328 |
|
| 2008 |
Long J, Gallagher TR, Cavey JR, Sheppard PW, Ralston SH, Layfield R, Searle MS. Ubiquitin recognition by the ubiquitin-associated domain of p62 involves a novel conformational switch. The Journal of Biological Chemistry. 283: 5427-40. PMID 18083707 DOI: 10.1074/Jbc.M704973200 |
0.424 |
|
| 2008 |
Evans CL, Long JE, Gallagher TR, Hirst JD, Searle MS. Conformation and dynamics of the three-helix bundle UBA domain of p62 from experiment and simulation. Proteins. 71: 227-40. PMID 17932931 DOI: 10.1002/Prot.21692 |
0.596 |
|
| 2007 |
Kouvatsos N, Thurston V, Ball K, Oldham NJ, Thomas NR, Searle MS. Bile acid interactions with rabbit ileal lipid binding protein and an engineered helixless variant reveal novel ligand binding properties of a versatile beta-clam shell protein scaffold. Journal of Molecular Biology. 371: 1365-77. PMID 17618650 DOI: 10.1016/J.Jmb.2007.06.024 |
0.41 |
|
| 2007 |
Balkwill GD, Williams HE, Searle MS. Structure and folding dynamics of a DNA hairpin with a stabilising d(GNA) trinucleotide loop: influence of base pair mis-matches and point mutations on conformational equilibria. Organic & Biomolecular Chemistry. 5: 832-9. PMID 17315071 DOI: 10.1039/B616820E |
0.421 |
|
| 2007 |
Long J, Layfield R, Searle M. NMR structure of the ubiquitin associated (UBA) domain of p62 (SQSTM1). RDC refined Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Jy7/Pdb |
0.335 |
|
| 2007 |
Long J, Layfield R, Searle M. NMR structure of the ubiquitin associated (UBA) domain of p62 (SQSTM1) in complex with ubiquitin. RDC refined Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr15592 |
0.344 |
|
| 2006 |
Kouvatsos N, Meldrum JK, Searle MS, Thomas NR. Coupling ligand recognition to protein folding in an engineered variant of rabbit ileal lipid binding protein. Chemical Communications (Cambridge, England). 4623-5. PMID 17082863 DOI: 10.1039/B610130E |
0.388 |
|
| 2006 |
Layfield R, Cavey JR, Najat D, Long J, Sheppard PW, Ralston SH, Searle MS. p62 mutations, ubiquitin recognition and Paget's disease of bone. Biochemical Society Transactions. 34: 735-7. PMID 17052185 DOI: 10.1042/Bst0340735 |
0.378 |
|
| 2006 |
Crespo MD, Simpson ER, Searle MS. Population of on-pathway intermediates in the folding of ubiquitin. Journal of Molecular Biology. 360: 1053-66. PMID 16815444 DOI: 10.1016/J.Jmb.2006.05.061 |
0.333 |
|
| 2006 |
Cavey JR, Ralston SH, Sheppard PW, Ciani B, Gallagher TR, Long JE, Searle MS, Layfield R. Loss of ubiquitin binding is a unifying mechanism by which mutations of SQSTM1 cause Paget's disease of bone. Calcified Tissue International. 78: 271-7. PMID 16691492 DOI: 10.1007/S00223-005-1299-6 |
0.358 |
|
| 2006 |
Simpson ER, Meldrum JK, Searle MS. Engineering diverse changes in beta-turn propensities in the N-terminal beta-hairpin of ubiquitin reveals significant effects on stability and kinetics but a robust folding transition state. Biochemistry. 45: 4220-30. PMID 16566596 DOI: 10.1021/Bi052495G |
0.357 |
|
| 2005 |
Bofill R, Searle MS. Engineering stabilising beta-sheet interactions into a conformationally flexible region of the folding transition state of ubiquitin. Journal of Molecular Biology. 353: 373-84. PMID 16169558 DOI: 10.1016/J.Jmb.2005.08.044 |
0.399 |
|
| 2005 |
Bofill R, Simpson ER, Platt GW, Crespo MD, Searle MS. Extending the folding nucleus of ubiquitin with an independently folding beta-hairpin finger: hurdles to rapid folding arising from the stabilisation of local interactions. Journal of Molecular Biology. 349: 205-21. PMID 15876378 DOI: 10.1016/J.Jmb.2005.03.048 |
0.401 |
|
| 2005 |
Cavey JR, Ralston SH, Hocking LJ, Sheppard PW, Ciani B, Searle MS, Layfield R. Loss of ubiquitin-binding associated with Paget's disease of bone p62 (SQSTM1) mutations. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 20: 619-24. PMID 15765181 DOI: 10.1359/Jbmr.041205 |
0.361 |
|
| 2004 |
Crespo MD, Platt GW, Bofill R, Searle MS. Context-dependent effects of proline residues on the stability and folding pathway of ubiquitin. European Journal of Biochemistry / Febs. 271: 4474-84. PMID 15560788 DOI: 10.1111/J.1432-1033.2004.04392.X |
0.416 |
|
| 2004 |
Layfield R, Ciani B, Ralston SH, Hocking LJ, Sheppard PW, Searle MS, Cavey JR. Structural and functional studies of mutations affecting the UBA domain of SQSTM1 (p62) which cause Paget's disease of bone. Biochemical Society Transactions. 32: 728-30. PMID 15493999 DOI: 10.1042/Bst0320728 |
0.372 |
|
| 2004 |
Searle MS, Ciani B. Design of beta-sheet systems for understanding the thermodynamics and kinetics of protein folding. Current Opinion in Structural Biology. 14: 458-64. PMID 15313241 DOI: 10.1016/J.Sbi.2004.06.001 |
0.333 |
|
| 2004 |
Hocking LJ, Lucas GJ, Daroszewska A, Cundy T, Nicholson GC, Donath J, Walsh JP, Finlayson C, Cavey JR, Ciani B, Sheppard PW, Searle MS, Layfield R, Ralston SH. Novel UBA domain mutations of SQSTM1 in Paget's disease of bone: genotype phenotype correlation, functional analysis, and structural consequences. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 19: 1122-7. PMID 15176995 DOI: 10.1359/Jbmr.0403015 |
0.341 |
|
| 2004 |
Searle MS. Insights into stabilizing weak interactions in designed peptide beta-hairpins. Biopolymers. 76: 185-95. PMID 15054898 DOI: 10.1002/Bip.10577 |
0.348 |
|
| 2004 |
Searle MS, Williams HE, Gallagher CT, Grant RJ, Stevens MF. Structure and K+ ion-dependent stability of a parallel-stranded DNA quadruplex containing a core A-tetrad. Organic & Biomolecular Chemistry. 2: 810-2. PMID 15007406 DOI: 10.1039/B314559J |
0.37 |
|
| 2003 |
Ciani B, Jourdan M, Searle MS. Stabilization of beta-hairpin peptides by salt bridges: role of preorganization in the energetic contribution of weak interactions. Journal of the American Chemical Society. 125: 9038-47. PMID 15369359 DOI: 10.1021/Ja030074L |
0.398 |
|
| 2003 |
Platt GW, Simpson SA, Layfield R, Searle MS. Stability and folding kinetics of a ubiquitin mutant with a strong propensity for nonnative beta-hairpin conformation in the unfolded state. Biochemistry. 42: 13762-71. PMID 14622023 DOI: 10.1021/Bi030147D |
0.414 |
|
| 2003 |
Gavathiotis E, Heald RA, Stevens MF, Searle MS. Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat. Journal of Molecular Biology. 334: 25-36. PMID 14596797 DOI: 10.1016/J.Jmb.2003.09.018 |
0.372 |
|
| 2003 |
Gallagher CT, Searle MS. Drug-induced stabilisation of a mismatched C-T base pair in a DNA hairpin. Chemical Communications (Cambridge, England). 1814-5. PMID 12931980 DOI: 10.1039/B305337G |
0.339 |
|
| 2003 |
Searle MS, Maynard AJ, Williams HE. DNA recognition by the anthracycline antibiotic respinomycin D: NMR structure of the intercalation complex with d(AGACGTCT)2. Organic & Biomolecular Chemistry. 1: 60-6. PMID 12929391 DOI: 10.1039/B208622K |
0.382 |
|
| 2003 |
Gavathiotis E, Searle MS. Structure of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat: evidence for A-tetrad formation from NMR and molecular dynamics simulations. Organic & Biomolecular Chemistry. 1: 1650-6. PMID 12926351 DOI: 10.1039/B300845M |
0.398 |
|
| 2003 |
Ciani B, Layfield R, Cavey JR, Sheppard PW, Searle MS. Structure of the ubiquitin-associated domain of p62 (SQSTM1) and implications for mutations that cause Paget's disease of bone. The Journal of Biological Chemistry. 278: 37409-12. PMID 12857745 DOI: 10.1074/Jbc.M307416200 |
0.406 |
|
| 2002 |
Colgrave ML, Beck JL, Sheil MM, Searle MS. Electrospray ionisation mass spectrometric detection of weak non-covalent interactions in nogalamycin-DNA complexes. Chemical Communications (Cambridge, England). 556-7. PMID 12120121 DOI: 10.1039/B200235N |
0.328 |
|
| 2002 |
Williams HE, Colgrave ML, Searle MS. Drug recognition of a DNA single strand break: nogalamycin intercalation between coaxially stacked hairpins. European Journal of Biochemistry / Febs. 269: 1726-33. PMID 11895443 DOI: 10.1046/J.1432-1327.2002.02819.X |
0.391 |
|
| 2001 |
Gavathiotis E, Heald RA, Stevens MF, Searle MS. Recognition and Stabilization of Quadruplex DNA by a Potent New Telomerase Inhibitor: NMR Studies of the 2:1 Complex of a Pentacyclic Methylacridinium Cation with d(TTAGGGT)(4) We thank the EPSRC of the UK and AstraZeneca for financial support to E.G. M.F.G.S. and R.A.H. are supported by the Cancer Research Campaign of the UK. Angewandte Chemie (International Ed. in English). 40: 4749-4751. PMID 12404405 DOI: 10.1002/1521-3773(20011217)40:24<4749::Aid-Anie4749>3.0.Co;2-I |
0.359 |
|
| 2001 |
Harris SA, Gavathiotis E, Searle MS, Orozco M, Laughton CA. Cooperativity in drug-DNA recognition: a molecular dynamics study. Journal of the American Chemical Society. 123: 12658-63. PMID 11741431 DOI: 10.1021/Ja016233N |
0.389 |
|
| 2001 |
Jourdan M, Searle MS. Insights into the stability of native and partially folded states of ubiquitin: effects of cosolvents and denaturants on the thermodynamics of protein folding. Biochemistry. 40: 10317-25. PMID 11513610 DOI: 10.1021/Bi010767J |
0.332 |
|
| 2001 |
Bostock-Smith CE, Harris SA, Laughton CA, Searle MS. Induced fit DNA recognition by a minor groove binding analogue of Hoechst 33258: Fluctuations in DNA A tract structure investigated by NMR and molecular dynamics simulations Nucleic Acids Research. 29: 693-702. PMID 11160891 DOI: 10.1093/Nar/29.3.693 |
0.442 |
|
| 2001 |
Platt G, Chung CW, Searle MS. Design of histidine-Zn2+ binding sites within a β-hairpin peptide: Enhancement of β-sheet stability through metal complexation Chemical Communications. 1162-1163. DOI: 10.1039/B100702P |
0.302 |
|
| 2001 |
Colgrave ML, Williams HEL, Searle MS. Binding of anthracycline antibiotic nogalamycin to the site of a DNA single strand break engineered between two co-axially stacked hairpins Chemical Communications. 315-316. DOI: 10.1039/B009904J |
0.388 |
|
| 2001 |
Searle MS. Peptide models of protein β-sheets: Design, folding and insights into stabilising weak interactions Journal of the Chemical Society, Perkin Transactions 2. 1011-1020. DOI: 10.1039/B008074H |
0.301 |
|
| 2000 |
Jourdan M, Searle MS. Cooperative assembly of a nativelike ubiquitin structure through peptide fragment complexation: energetics of peptide association and folding. Biochemistry. 39: 12355-64. PMID 11015215 DOI: 10.1021/Bi000718R |
0.426 |
|
| 2000 |
Jourdan M, Griffiths-Jones SR, Searle MS. Folding of a beta-hairpin peptide derived from the N-terminus of ubiquitin. Conformational preferences of beta-turn residues dictate non-native beta-strand interactions. European Journal of Biochemistry / Febs. 267: 3539-48. PMID 10848970 DOI: 10.1046/J.1432-1327.2000.01381.X |
0.387 |
|
| 2000 |
Searle MS, Jourdan M. Templating peptide folding on the surface of a micelle: nucleating the formation of a beta-hairpin. Bioorganic & Medicinal Chemistry Letters. 10: 1139-42. PMID 10843236 DOI: 10.1016/S0960-894X(00)00192-X |
0.346 |
|
| 2000 |
Gavathiotis E, Sharman GJ, Searle MS. Sequence-dependent variation in DNA minor groove width dictates orientational preference of Hoechst 33258 in A-tract recognition: solution NMR structure of the 2:1 complex with d(CTTTTGCAAAAG)(2). Nucleic Acids Research. 28: 728-35. PMID 10637324 DOI: 10.1093/Nar/28.3.728 |
0.415 |
|
| 2000 |
Colley CS, Clark IP, Griffiths-Jones SR, George MW, Searle MS. Steady state and time-resolved IR spectroscopy of the native and unfolded states of bovine ubiquitin: protein stability and temperature-jump kinetic measurements of protein folding at low pH Chemical Communications. 1493-1494. DOI: 10.1039/B003768K |
0.314 |
|
| 2000 |
Colley CS, Griffiths-Jones SR, George MW, Searle MS. Do interstrand hydrogen bonds contribute to β-hairpin peptide stability in solution? IR analysis of peptide folding in water Chemical Communications. 7: 593-594. DOI: 10.1039/B000426J |
0.319 |
|
| 2000 |
Bostock-Smith CE, Sharman GJ, Sockett RE, Searle MS. Evidence for β-sheet conformation in vesicle-bound peptides derived from the transmembrane bacterial flagellar motor protein MotB from Rhodobacter sphaeroides Journal of the Chemical Society. Perkin Transactions 2. 479-483. DOI: 10.1039/A908618H |
0.341 |
|
| 2000 |
and SRG, Searle MS. Structure, folding, and energetics of cooperative interactions between the beta-strands of a de novo sesigned three-stranded antiparallel beta-sheet peptide Journal of the American Chemical Society. 122: 8350-8356. DOI: 10.1021/Ja000787T |
0.333 |
|
| 1999 |
Griffiths-Jones SR, Maynard AJ, Searle MS. Dissecting the stability of a beta-hairpin peptide that folds in water: NMR and molecular dynamics analysis of the beta-turn and beta-strand contributions to folding. Journal of Molecular Biology. 292: 1051-69. PMID 10512702 DOI: 10.1006/Jmbi.1999.3119 |
0.388 |
|
| 1999 |
Bostock-Smith CE, Laughton CA, Searle MS. Solution structure and dynamics of the A-T tract DNA decamer duplex d(GGTAATTACC)2: implications for recognition by minor groove binding drugs. The Biochemical Journal. 342: 125-32. PMID 10432309 DOI: 10.1042/Bj3420125 |
0.418 |
|
| 1999 |
Williams HE, Searle MS. Structure, dynamics and hydration of the nogalamycin-d(ATGCAT)2Complex determined by NMR and molecular dynamics simulations in solution. Journal of Molecular Biology. 290: 699-716. PMID 10395824 DOI: 10.1006/Jmbi.1999.2903 |
0.392 |
|
| 1999 |
Bostock-Smith CE, Giménez-Arnau E, Missailidis S, Laughton CA, Stevens MF, Searle MS. Molecular recognition between a new pentacyclic acridinium salt and DNA sequences investigated by optical spectroscopic techniques, proton nuclear magnetic resonance spectroscopy, and molecular modeling. Biochemistry. 38: 6723-31. PMID 10346892 DOI: 10.1021/Bi9825807 |
0.357 |
|
| 1999 |
Bostock-Smith CE, Searle MS. DNA minor groove recognition by bis-benzimidazole analogues of Hoechst 33258: insights into structure-DNA affinity relationships assessed by fluorescence titration measurements. Nucleic Acids Research. 27: 1619-24. PMID 10075992 DOI: 10.1093/Nar/27.7.1619 |
0.407 |
|
| 1999 |
Higgins LD, Searle MS. Site-specificity of bis-benzimidazole Hoechst 33258 in A-tract recognition of the DNA dodecamer duplex d(GCAAAATTTTGC)2 Chemical Communications. 1861-1862. DOI: 10.1039/A905232A |
0.39 |
|
| 1999 |
Searle MS, Griffiths-Jones SR, Skinner-Smith H. Energetics of weak interactions in a β-hairpin peptide: Electrostatic and hydrophobic contributions to stability from lysine salt bridges Journal of the American Chemical Society. 121: 11615-11620. DOI: 10.1021/Ja992029C |
0.387 |
|
| 1998 |
Griffiths-Jones SR, Sharman GJ, Maynard AJ, Searle MS. Modulation of intrinsic phi,psi propensities of amino acids by neighbouring residues in the coil regions of protein structures: NMR analysis and dissection of a beta-hairpin peptide. Journal of Molecular Biology. 284: 1597-609. PMID 9878373 DOI: 10.1006/Jmbi.1998.2264 |
0.388 |
|
| 1998 |
Sharman GJ, Kenward N, Williams HE, Landon M, Mayer RJ, Searle MS. Prion protein fragments spanning helix 1 and both strands of beta sheet (residues 125-170) show evidence for predominantly helical propensity by CD and NMR. Folding & Design. 3: 313-20. PMID 9806936 DOI: 10.1016/S1359-0278(98)00043-1 |
0.402 |
|
| 1998 |
Bostock-Smith CE, Laughton CA, Searle MS. DNA minor groove recognition by a tetrahydropyrimidinium analogue of hoechst 33258: NMR and molecular dynamics studies of the complex with d(GGTAATTACC)2. Nucleic Acids Research. 26: 1660-7. PMID 9512536 DOI: 10.1093/Nar/26.7.1660 |
0.432 |
|
| 1998 |
Williams HE, Searle MS. Structure of the nogalamycin-d(ATGCAT)2 complex in solution: DNA recognition at an isolated TpG site Journal of the Chemical Society - Perkin Transactions 1. 3-5. DOI: 10.1039/A707093D |
0.369 |
|
| 1998 |
Maynard AJ, Sharman GJ, Searle MS. Origin of β-hairpin stability in solution: Structural and thermodynamic analysis of the folding of a model peptide supports hydrophobic stabilization in water Journal of the American Chemical Society. 120: 1996-2007. DOI: 10.1021/Ja9726769 |
0.386 |
|
| 1998 |
Sharman GJ, Searle MS. Cooperative interaction between the three strands of a designed antiparallel β-sheet Journal of the American Chemical Society. 120: 5291-5300. DOI: 10.1021/Ja9705405 |
0.353 |
|
| 1997 |
Maynard AJ, Searle MS. NMR structural analysis of a β-hairpin peptide designed for DNA binding Chemical Communications. 1297-1298. DOI: 10.1039/A702593I |
0.373 |
|
| 1997 |
Bostock-Smith CE, Embrey KJ, Searle MS. Enhanced binding of a hexacyclic amidine analogue of Hoechst 33258 to the minor groove of DNA: 1H NMR and UV melting studies with the decamer duplex d(GGTAATTACC)2 Chemical Communications. 121-122. DOI: 10.1039/A606847B |
0.389 |
|
| 1996 |
Searle MS, Zerella R, Williams DH, Packman LC. Native-like beta-hairpin structure in an isolated fragment from ferredoxin: NMR and CD studies of solvent effects on the N-terminal 20 residues. Protein Engineering. 9: 559-65. PMID 8844827 DOI: 10.1093/Protein/9.7.559 |
0.403 |
|
| 1995 |
Searle MS, Williams DH, Packman LC. A short linear peptide derived from the N-terminal sequence of ubiquitin folds into a water-stable non-native beta-hairpin. Nature Structural Biology. 2: 999-1006. PMID 7583674 DOI: 10.1038/Nsb1195-999 |
0.363 |
|
| 1995 |
Searle MS, Westwell MS, Williams DH. Application of a generalised Enthalpy-entropy relationship to binding Co-operativity and weak associations in solution Journal of the Chemical Society, Perkin Transactions 2. 141-151. DOI: 10.1039/P29950000141 |
0.351 |
|
| 1995 |
Groves P, Searle MS, Waltho JP, Williams DH. Asymmetry in the structure of glycopeptide antibiotic dimers: NMR studies of the ristocetin A complex with a bacterial cell wall analogue Journal of the American Chemical Society. 117: 7958-7964. DOI: 10.1021/Ja00135A014 |
0.32 |
|
| 1995 |
Sharman GJ, Searle MS, Benhamu B, Groves P, Williams DH. Burial of Hydrocarbon Causes Cooperative Enhancement of Electrostatic Binding Angewandte Chemie International Edition in English. 34: 1483-1485. DOI: 10.1002/Anie.199514831 |
0.336 |
|
| 1994 |
Groves P, Searle MS, Mackay JP, Williams DH. The structure of an asymmetric dimer relevant to the mode of action of the glycopeptide antibiotics. Structure (London, England : 1993). 2: 747-54. PMID 7994574 DOI: 10.1016/S0969-2126(94)00075-1 |
0.399 |
|
| 1994 |
Searle MS. Binding of quinomycin antibiotic UK-65,662 to DNA: 1H-n.m.r. studies of drug-induced changes in DNA conformation in complexes with d(ACGT)2 and d(GACGTC)2. The Biochemical Journal. 304: 967-79. PMID 7818504 |
0.318 |
|
| 1994 |
Williams DH, Searle MS, Groves P, Mackay JP, Westwell MS, Beauregard DA, Cristofaro MF. Functional roles of natural products: The involvement of extended arrays of weak interactions in cooperative binding phenomena Pure and Applied Chemistry. 66: 1975-1982. DOI: 10.1351/Pac199466101975 |
0.353 |
|
| 1994 |
Groves P, Searle MS, Chicarelli-Robinson I, Williams DH. Recognition of the cell-wall binding site of the vancomycin-group antibiotics by unnatural structural motifs: 1H NMR studies of the effects of ligand binding on antibiotic dimerisation Journal of the Chemical Society, Perkin Transactions 1. 659-665. DOI: 10.1039/P19940000659 |
0.412 |
|
| 1994 |
Groves P, Searle MS, Westwell MS, Williams DH. Expression of electrostatic binding cooperativity in the recognition of cell-wall peptide analogues by vancomycin group antibiotics Journal of the Chemical Society, Chemical Communications. 1519-1520. DOI: 10.1039/C39940001519 |
0.377 |
|
| 1993 |
Williams DH, Searle MS, Mackay JP, Gerhard U, Maplestone RA. Toward an estimation of binding constants in aqueous solution: studies of associations of vancomycin group antibiotics. Proceedings of the National Academy of Sciences of the United States of America. 90: 1172-8. PMID 8433979 DOI: 10.1073/Pnas.90.4.1172 |
0.359 |
|
| 1993 |
Searle MS, Williams DH. On the stability of nucleic acid structures in solution: enthalpy-entropy compensations, internal rotations and reversibility. Nucleic Acids Research. 21: 2051-6. PMID 7684832 DOI: 10.1093/Nar/21.9.2051 |
0.38 |
|
| 1993 |
Embrey KJ, Searle MS, Craik DJ. Interaction of Hoechst 33258 with the minor groove of the A + T-rich DNA duplex d(GGTAATTACC)2 studied in solution by NMR spectroscopy. European Journal of Biochemistry / Febs. 211: 437-47. PMID 7679636 DOI: 10.1111/J.1432-1033.1993.Tb17569.X |
0.322 |
|
| 1993 |
Gerhard U, Searle MS, Williams DH. The free energy change of restricting a bond rotation in the binding of peptide analogues to vancomycin group antibiotics Bioorganic and Medicinal Chemistry Letters. 3: 803-808. DOI: 10.1016/S0960-894X(00)80670-8 |
0.337 |
|
| 1993 |
Holroyd SE, Groves P, Searle MS, Gerhard U, Williams DH. Rational design and binding of modified cell-wall peptides to vancomycin-group antibiotics: Factorising free energy contributions to binding Tetrahedron. 49: 9171-9182. DOI: 10.1016/0040-4020(93)80004-D |
0.367 |
|
| 1992 |
Searle MS, Bicknell W. Interaction of the anthracycline antibiotic nogalamycin with the hexamer duplex d(5'-GACGTC)2. An NMR and molecular modelling study. European Journal of Biochemistry / Febs. 205: 45-58. PMID 1555603 DOI: 10.1111/J.1432-1033.1992.Tb16750.X |
0.427 |
|
| 1992 |
Searle MS, Williams DH, Gerhard U. Partitioning of free energy contributions in the estimation of binding constants: residual motions and consequences for amide-amide hydrogen bond strengths Journal of the American Chemical Society. 114: 10697-10704. DOI: 10.1021/Ja00053A003 |
0.359 |
|
| 1992 |
Searle MS, Williams DH. The cost of conformational order: entropy changes in molecular associations Journal of the American Chemical Society. 114: 10690-10697. DOI: 10.1021/Ja00053A002 |
0.307 |
|
| 1992 |
Searle MS, Williams DH. Consequences for molecular recognition and ligand-receptor complementary of entropy changes in phase transitions Bioorganic and Medicinal Chemistry Letters. 2: 993-996. DOI: 10.1016/S0960-894X(00)80604-6 |
0.321 |
|
| 1991 |
Munro S, Craik D, McConville C, Hall J, Searle M, Bicknell W, Scanlon D, Chandler C. Solution conformation of endothelin, a potent vaso-constricting bicyclic peptide. A combined use of 1H NMR spectroscopy and distance geometry calculations. Febs Letters. 278: 9-13. PMID 1993480 DOI: 10.1016/0014-5793(91)80071-A |
0.37 |
|
| 1991 |
Searle MS, Bicknell W, Wakelin LPG, Denny WA. Anthracycline antibiotic arugomycin binds in both grooves of the DNA helix simultaneously: An NMR and molecular modelling study Nucleic Acids Research. 19: 2897-2906. PMID 1647521 DOI: 10.1093/Nar/19.11.2897 |
0.433 |
|
| 1990 |
Searle MS, Wakelin LPG. Sequence specific conformation of a DNA decamer containing an adenine tract studied in solution by 1H-NMR spectroscopy Bba - Gene Structure and Expression. 1049: 69-77. PMID 2357466 DOI: 10.1016/0167-4781(90)90085-G |
0.386 |
|
| 1989 |
Searle MS, Hall JG, Denny WA, Wakelin LPG. Interaction of the antitumour antibiotic luzopeptin with the hexanucleotide duplex d(5'-GCATGC)2. One-dimensional and two-dimensional n.m.r. studies Biochemical Journal. 259: 433-441. PMID 2719658 DOI: 10.1042/Bj2590433 |
0.393 |
|
| 1989 |
Searle MS, Hall JG, Kyratzis I, Wakelin LPG. Didemnin B. Conformation and dynamics of an antitumour and antiviral depsipertide studied in solution by 1H and 13C. n.m.r. spectroscopy International Journal of Peptide and Protein Research. 34: 445-454. PMID 2561421 DOI: 10.1111/J.1399-3011.1989.Tb01393.X |
0.413 |
|
| 1988 |
Searle MS, Hall JG, Denny WA, Wakelin LPG. NMR studies of the interaction of the antibiotic nogalamycin with the hexadeoxyribonucleotide duplex d(5′-GCATGC)2 1 Biochemistry®. 27: 4340-4349. PMID 3166981 DOI: 10.1021/Bi00412A022 |
0.42 |
|
| 1988 |
Searle MS, Forster MJ, Birdsall B, Roberts GC, Feeney J, Cheung HT, Kompis I, Geddes AJ. Dynamics of trimethoprim bound to dihydrofolate reductase. Proceedings of the National Academy of Sciences of the United States of America. 85: 3787-91. PMID 3131763 DOI: 10.1073/Pnas.85.11.3787 |
0.508 |
|
| 1987 |
Hammond SJ, Birdsall B, Feeney J, Searle MS, Roberts GC, Cheung HT. Structural comparisons of complexes of methotrexate analogues with Lactobacillus casei dihydrofolate reductase by two-dimensional 1H NMR at 500 MHz. Biochemistry. 26: 8585-90. PMID 3126805 DOI: 10.1021/Bi00400A014 |
0.486 |
|
| 1987 |
Birdsall B, De Graw J, Feeney J, Hammond S, Searle MS, Roberts GC, Colwell WT, Crase J. 15N and 1H NMR evidence for multiple conformations of the complex of dihydrofolate reductase with its substrate, folate. Febs Letters. 217: 106-10. PMID 3109940 DOI: 10.1016/0014-5793(87)81252-8 |
0.494 |
|
| 1986 |
Cheung HT, Searle MS, Feeney J, Birdsall B, Roberts GC, Kompis I, Hammond SJ. Trimethoprim binding to Lactobacillus casei dihydrofolate reductase: a 13C NMR study using selectively 13C-enriched trimethoprim. Biochemistry. 25: 1925-31. PMID 3085709 DOI: 10.1021/Bi00356A014 |
0.482 |
|
| 1986 |
Searle MS, Hammond SJ, Birdsall B, Roberts GC, Feeney J, King RW, Griffiths DV. Identification of the 1H resonances of valine and leucine residues in dihydrofolate reductase by using a combination of selective deuteration and two-dimensional correlation spectroscopy. Febs Letters. 194: 165-70. PMID 3079708 DOI: 10.1016/0014-5793(86)80070-9 |
0.465 |
|
| 1986 |
Hammond SJ, Birdsall B, Searle MS, Roberts GC, Feeney J. Dihydrofolate reductase. 1H resonance assignments and coenzyme-induced conformational changes. Journal of Molecular Biology. 188: 81-97. PMID 3012098 DOI: 10.1016/0022-2836(86)90483-3 |
0.51 |
|
| 1984 |
Birdsall B, Feeney J, Griffiths DV, Hammond S, Kimber B, King RW, Roberts GC, Searle M. The combined use of selective deuteration and double resonance experiments in assigning the 1H resonances of valine and tyrosine residues of dihydrofolate reductase. Febs Letters. 175: 364-8. PMID 6434351 DOI: 10.1016/0014-5793(84)80769-3 |
0.434 |
|
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