Year |
Citation |
Score |
2009 |
Moro WB, Yang Z, Kane TA, Zhou Q, Harville S, Brouillette CG, Brouillette WJ. SAR studies for a new class of antibacterial NAD biosynthesis inhibitors. Journal of Combinatorial Chemistry. 11: 617-25. PMID 19408950 DOI: 10.1021/Cc9000357 |
0.381 |
|
2009 |
Moro WB, Yang Z, Kane TA, Brouillette CG, Brouillette WJ. Virtual screening to identify lead inhibitors for bacterial NAD synthetase (NADs). Bioorganic & Medicinal Chemistry Letters. 19: 2001-5. PMID 19249205 DOI: 10.1016/J.Bmcl.2009.02.034 |
0.304 |
|
2007 |
McDonald HM, Pruett PS, Deivanayagam C, Protasevich II, Carson WM, DeLucas LJ, Brouillette WJ, Brouillette CG. Structural adaptation of an interacting non-native C-terminal helical extension revealed in the crystal structure of NAD+ synthetase from Bacillus anthracis. Acta Crystallographica. Section D, Biological Crystallography. 63: 891-905. PMID 17642516 DOI: 10.1107/S0907444907029769 |
0.348 |
|
2007 |
Velu SE, Mou L, Luan CH, Yang ZW, DeLucas LJ, Brouillette CG, Brouillette WJ. Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: amide- and ether-linked tethered dimers with alpha-amino acid end groups. Journal of Medicinal Chemistry. 50: 2612-21. PMID 17489580 DOI: 10.1021/Jm061349L |
0.367 |
|
2005 |
Velu SE, Luan CH, Delucas LJ, Brouillette CG, Brouillette WJ. Tethered dimer inhibitors of NAD synthetase: parallel synthesis of an aryl-substituted SAR library. Journal of Combinatorial Chemistry. 7: 898-904. PMID 16283799 DOI: 10.1021/Cc050063J |
0.344 |
|
2004 |
Protasevich II, Brouillette CG, Snow ME, Dunham S, Rubin JR, Gogliotti R, Siegel K. Role of inhibitor aliphatic chain in the thermodynamics of inhibitor binding to Escherichia coli enoyl-ACP reductase and the Phe203Leu mutant: a proposed mechanism for drug resistance. Biochemistry. 43: 13380-9. PMID 15491144 DOI: 10.1021/bi0492509 |
0.402 |
|
2004 |
Yang ZW, Tendian SW, Carson WM, Brouillette WJ, Delucas LJ, Brouillette CG. Dimethyl sulfoxide at 2.5% (v/v) alters the structural cooperativity and unfolding mechanism of dimeric bacterial NAD+ synthetase. Protein Science : a Publication of the Protein Society. 13: 830-41. PMID 14978314 DOI: 10.1110/Ps.03330104 |
0.302 |
|
2003 |
Chesnokova LS, Slepenkov SV, Protasevich II, Sehorn MG, Brouillette CG, Witt SN. Deletion of DnaK's lid strengthens binding to the nucleotide exchange factor, GrpE: a kinetic and thermodynamic analysis. Biochemistry. 42: 9028-40. PMID 12885236 DOI: 10.1021/Bi0346493 |
0.303 |
|
2003 |
Velu SE, Cristofoli WA, Garcia GJ, Brouillette CG, Pierson MC, Luan CH, DeLucas LJ, Brouillette WJ. Tethered dimers as NAD synthetase inhibitors with antibacterial activity. Journal of Medicinal Chemistry. 46: 3371-81. PMID 12852767 DOI: 10.1021/Jm030003X |
0.34 |
|
2001 |
Devedjiev Y, Symersky J, Singh R, Jedrzejas M, Brouillette C, Brouillette W, Muccio D, Chattopadhyay D, DeLucas L. Stabilization of active-site loops in NH3-dependent NAD+ synthetase from Bacillus subtilis. Acta Crystallographica. Section D, Biological Crystallography. 57: 806-12. PMID 11375500 DOI: 10.1107/S0907444901003523 |
0.365 |
|
1999 |
Parker MH, Lunney EA, Ortwine DF, Pavlovsky AG, Humblet C, Brouillette CG. Analysis of the binding of hydroxamic acid and carboxylic acid inhibitors to the stromelysin-1 (matrix metalloproteinase-3) catalytic domain by isothermal titration calorimetry. Biochemistry. 38: 13592-601. PMID 10521266 DOI: 10.1021/BI991222G |
0.342 |
|
1992 |
Lim WK, Brouillette C, Hardman JK. Thermal stabilities of mutant Escherichia coli tryptophan synthase alpha subunits. Archives of Biochemistry and Biophysics. 292: 34-41. PMID 1727648 DOI: 10.1016/0003-9861(92)90047-Z |
0.327 |
|
1979 |
Brouillette CB, Chang CT, Mertes MP. 5-(alpha-Bromoacetyl)-2'-deoxyuridine 5'-phosphate: an affinity label for thymidylate synthetase. Journal of Medicinal Chemistry. 22: 1541-4. PMID 119854 DOI: 10.1021/Jm00198A022 |
0.472 |
|
1979 |
Brouillette CB, Chang CT, Mertes MP. 5 (alpha-bromoacetyl)-2'=deoxyuridine 5'-phosphate: a mechanism based affinity label for thymidylate synthetase. Biochemical and Biophysical Research Communications. 87: 613-8. PMID 109088 DOI: 10.1016/0006-291X(79)91838-2 |
0.472 |
|
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