| Year |
Citation |
Score |
| 2019 |
Mastracchio A, Lai C, Torrent M, Bromberg K, Buchanan FG, Ferguson D, Bontcheva V, Johnson EF, Lasko L, Maag D, Soni N, Shoemaker AR, Penning TD. Investigation of biaryl heterocycles as inhibitors of Wee1 kinase. Bioorganic & Medicinal Chemistry Letters. PMID 31014911 DOI: 10.1016/J.Bmcl.2019.04.017 |
0.335 |
|
| 2019 |
Hsu MH, Johnson EF. Active site differences between substrate-free and ritonavir-bound cytochrome P450 (CYP) 3A5 reveal plasticity differences between CYP3A5 and CYP3A4. The Journal of Biological Chemistry. PMID 30926609 DOI: 10.1074/Jbc.Ra119.007928 |
0.385 |
|
| 2018 |
Jennings GK, Hsu MH, Shock LS, Johnson EF, Hackett JC. Non-covalent interactions dominate dynamic heme distortion in cytochrome P450 4B1. The Journal of Biological Chemistry. PMID 29858244 DOI: 10.1074/Jbc.Ra118.004044 |
0.344 |
|
| 2017 |
Hsu MH, Savas U, Johnson EF. The X-ray Crystal Structure of the Human Monooxygenase Cytochrome P450 3A5-Ritonavir Complex Reveals Active Site Differences between P450s 3A4 and 3A5. Molecular Pharmacology. PMID 29093019 DOI: 10.1124/Mol.117.109744 |
0.303 |
|
| 2017 |
Liu R, Lyu X, Hsu MH, Vilcheze C, Franzblau SG, Jacobs WR, Besra GS, Johnson EF, Fütterer K, Wang F. Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes. Angewandte Chemie (International Ed. in English). PMID 28815830 DOI: 10.1002/Anie.201707324 |
0.306 |
|
| 2017 |
Albertolle ME, Kim D, Nagy LD, Yun CH, Pozzi A, Savas U, Johnson EF, Guengerich FP. Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition. The Journal of Biological Chemistry. PMID 28533430 DOI: 10.1074/Jbc.M117.792200 |
0.367 |
|
| 2017 |
Hsu MH, Baer BR, Rettie AE, Johnson EF. The Crystal Structure of Cytochrome P450 4B1 (CYP4B1) Monoxygenase Complexed with Octane Discloses Several Structural Adaptations for ω-Hydroxylation. The Journal of Biological Chemistry. PMID 28167536 DOI: 10.1074/Jbc.M117.775494 |
0.402 |
|
| 2016 |
Butler CR, Ogilvie K, Martinez-Alsina L, Barreiro G, Beck EM, Nolan CE, Atchison K, Benvenuti E, Buzon L, Doran S, Gonzales C, Helal CJ, Hou X, Hsu MH, Johnson EF, et al. Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality. Journal of Medicinal Chemistry. PMID 27997172 DOI: 10.1021/Acs.Jmedchem.6B01451 |
0.34 |
|
| 2016 |
Savas U, Wei S, Hsu MH, Falck JR, Guengerich FP, Capdevila JH, Johnson EF. 20-Hydroxyeicosatetraenoic Acid (HETE) Dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: Normalization of Blood Pressure by Sodium Restriction, Hydrochlorothiazide, or Blockade of the Type 1 Angiotensin II Receptor. The Journal of Biological Chemistry. PMID 27298316 DOI: 10.1074/Jbc.M116.732297 |
0.303 |
|
| 2015 |
Brodney MA, Beck EM, Butler CR, Barreiro G, Johnson EF, Riddell D, Parris K, Nolan CE, Fan Y, Atchison K, Gonzales C, Robshaw AE, Doran SD, Bundesmann MW, Buzon L, et al. Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors. Journal of Medicinal Chemistry. 58: 3223-52. PMID 25781223 DOI: 10.1021/Acs.Jmedchem.5B00191 |
0.324 |
|
| 2015 |
Tong Y, Torrent M, Florjancic AS, Bromberg KD, Buchanan FG, Ferguson DC, Johnson EF, Lasko LM, Maag D, Merta PJ, Olson AM, Osterling DJ, Soni N, Shoemaker AR, Penning TD. Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase. Acs Medicinal Chemistry Letters. 6: 58-62. PMID 25589931 DOI: 10.1021/Ml5002745 |
0.338 |
|
| 2015 |
Wang A, Stout CD, Zhang Q, Johnson EF. Contributions of ionic interactions and protein dynamics to cytochrome P450 2D6 (CYP2D6) substrate and inhibitor binding. The Journal of Biological Chemistry. 290: 5092-104. PMID 25555909 DOI: 10.1074/Jbc.M114.627661 |
0.35 |
|
| 2014 |
Johnson EF, Connick JP, Reed JR, Backes WL, Desai MC, Xu L, Estrada DF, Laurence JS, Scott EE. Correlating structure and function of drug-metabolizing enzymes: Progress and ongoing challenges Drug Metabolism and Disposition. 42: 9-22. PMID 24130370 DOI: 10.1124/Dmd.113.054627 |
0.393 |
|
| 2013 |
Tong Y, Stewart KD, Florjancic AS, Harlan JE, Merta PJ, Przytulinska M, Soni N, Swinger KK, Zhu H, Johnson EF, Shoemaker AR, Penning TD. Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195. Acs Medicinal Chemistry Letters. 4: 211-5. PMID 24900653 DOI: 10.1021/Ml300348C |
0.338 |
|
| 2013 |
Johnson EF, Stout CD. Structural diversity of eukaryotic membrane cytochrome p450s. The Journal of Biological Chemistry. 288: 17082-90. PMID 23632020 DOI: 10.1074/Jbc.R113.452805 |
0.367 |
|
| 2012 |
Reynald RL, Sansen S, Stout CD, Johnson EF. Structural characterization of human cytochrome P450 2C19: Active site differences between P450s 2C8, 2C9, and 2C19 Journal of Biological Chemistry. 287: 44581-44591. PMID 23118231 DOI: 10.1074/Jbc.M112.424895 |
0.391 |
|
| 2012 |
Zhang Q, Xia Z, Mitten MJ, Lasko LM, Klinghofer V, Bouska J, Johnson EF, Penning TD, Luo Y, Giranda VL, Shoemaker AR, Stewart KD, Djuric SW, Vasudevan A. Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitors Bioorganic and Medicinal Chemistry Letters. 22: 7615-7622. PMID 23103095 DOI: 10.1016/J.Bmcl.2012.10.009 |
0.311 |
|
| 2012 |
Glaser KB, Li J, Marcotte PA, Magoc TJ, Guo J, Reuter DR, Tapang P, Wei RQ, Pease LJ, Bui MH, Chen Z, Frey RR, Johnson EF, Osterling DJ, Olson AM, et al. Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families. The Journal of Pharmacology and Experimental Therapeutics. 343: 617-27. PMID 22935731 DOI: 10.1124/Jpet.112.197087 |
0.329 |
|
| 2012 |
Zhu GD, Gong J, Gandhi VB, Liu X, Shi Y, Johnson EF, Donawho CK, Ellis PA, Bouska JJ, Osterling DJ, Olson AM, Park C, Luo Y, Shoemaker A, Giranda VL, et al. Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer. Bioorganic & Medicinal Chemistry. 20: 4635-45. PMID 22766219 DOI: 10.1016/J.Bmc.2012.06.021 |
0.341 |
|
| 2012 |
Woods KW, Lai C, Miyashiro JM, Tong Y, Florjancic AS, Han EK, Soni N, Shi Y, Lasko L, Leverson JD, Johnson EF, Shoemaker AR, Penning TD. Aminopyrimidinone cdc7 kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 1940-3. PMID 22326396 DOI: 10.1016/J.Bmcl.2012.01.041 |
0.316 |
|
| 2012 |
Wang A, Savas U, Hsu MH, Stout CD, Johnson EF. Crystal structure of human cytochrome P450 2D6 with prinomastat bound. The Journal of Biological Chemistry. 287: 10834-43. PMID 22308038 DOI: 10.1074/Jbc.M111.307918 |
0.362 |
|
| 2012 |
Liu X, Shi Y, Maag DX, Palma JP, Patterson MJ, Ellis PA, Surber BW, Ready DB, Soni NB, Ladror US, Xu AJ, Iyer R, Harlan JE, Solomon LR, Donawho CK, ... ... Johnson EF, et al. Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 510-23. PMID 22128301 DOI: 10.1158/1078-0432.Ccr-11-1973 |
0.333 |
|
| 2011 |
Chen Z, Gopalakrishnan SM, Bui MH, Soni NB, Warrior U, Johnson EF, Donnelly JB, Glaser KB. 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. The Journal of Biological Chemistry. 286: 43951-8. PMID 22020937 DOI: 10.1074/Jbc.M111.301291 |
0.313 |
|
| 2011 |
Bumpus NN, Johnson EF. 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated protein kinase-independent. The Journal of Pharmacology and Experimental Therapeutics. 339: 886-95. PMID 21896918 DOI: 10.1124/Jpet.111.184242 |
0.653 |
|
| 2011 |
Shi Y, Solomon LR, Pereda-Lopez A, Giranda VL, Luo Y, Johnson EF, Shoemaker AR, Leverson J, Liu X. Ubiquitin-specific cysteine protease 2a (USP2a) regulates the stability of Aurora-A. The Journal of Biological Chemistry. 286: 38960-8. PMID 21890637 DOI: 10.1074/Jbc.M111.231498 |
0.318 |
|
| 2011 |
Akritopoulou-Zanze I, Wakefield BD, Gasiecki A, Kalvin D, Johnson EF, Kovar P, Djuric SW. Scaffold oriented synthesis. Part 4: design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing heterocycle forming and multicomponent reactions. Bioorganic & Medicinal Chemistry Letters. 21: 1480-3. PMID 21288717 DOI: 10.1016/J.Bmcl.2011.01.001 |
0.304 |
|
| 2011 |
Akritopoulou-Zanze I, Wakefield BD, Gasiecki A, Kalvin D, Johnson EF, Kovar P, Djuric SW. Scaffold oriented synthesis. Part 3: design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing [2+3] cycloadditions. Bioorganic & Medicinal Chemistry Letters. 21: 1476-9. PMID 21282054 DOI: 10.1016/J.Bmcl.2011.01.007 |
0.306 |
|
| 2011 |
Hsu MH, Savas U, Lasker JM, Johnson EF. Genistein, resveratrol, and 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside induce cytochrome P450 4F2 expression through an AMP-activated protein kinase-dependent pathway. The Journal of Pharmacology and Experimental Therapeutics. 337: 125-36. PMID 21205922 DOI: 10.1124/Jpet.110.175851 |
0.359 |
|
| 2011 |
Wang A, Savas U, Stout CD, Johnson EF. Structural characterization of the complex between alpha-naphthoflavone and human cytochrome P450 1B1. The Journal of Biological Chemistry. 286: 5736-43. PMID 21147782 DOI: 10.1074/Jbc.M110.204420 |
0.411 |
|
| 2011 |
Glaser KB, Li J, Marcotte PA, Magoc TJ, Guo J, Reuter DR, Tapang P, Wei R, Pease LJ, Bui MH, Chen Z, Frey RR, Johnson EF, Osterling DJ, Olson AM, et al. Abstract A239: Preclinical characterization of ABT-348, a kinase inhibitor targeting the Aurora, VEGFR/PDGFR, and SRC kinase families. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-A239 |
0.335 |
|
| 2010 |
Wang GT, Mantei RA, Hubbard RD, Wilsbacher JL, Zhang Q, Tucker L, Hu X, Kovar P, Johnson EF, Osterling DJ, Bouska J, Wang J, Davidsen SK, Bell RL, Sheppard GS. Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases. Bioorganic & Medicinal Chemistry Letters. 20: 6067-71. PMID 20817523 DOI: 10.1016/J.Bmcl.2010.08.052 |
0.31 |
|
| 2010 |
Penning TD, Zhu GD, Gong J, Thomas S, Gandhi VB, Liu X, Shi Y, Klinghofer V, Johnson EF, Park CH, Fry EH, Donawho CK, Frost DJ, Buchanan FG, Bukofzer GT, et al. Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitor. Journal of Medicinal Chemistry. 53: 3142-53. PMID 20337371 DOI: 10.1021/Jm901775Y |
0.34 |
|
| 2010 |
Gandhi VB, Luo Y, Liu X, Shi Y, Klinghofer V, Johnson EF, Park C, Giranda VL, Penning TD, Zhu GD. Discovery and SAR of substituted 3-oxoisoindoline-4-carboxamides as potent inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. Bioorganic & Medicinal Chemistry Letters. 20: 1023-6. PMID 20045315 DOI: 10.1016/J.Bmcl.2009.12.042 |
0.306 |
|
| 2010 |
Annalora AJ, Goodin DB, Hong WX, Zhang Q, Johnson EF, Stout CD. Crystal structure of CYP24A1, a mitochondrial cytochrome P450 involved in vitamin D metabolism. Journal of Molecular Biology. 396: 441-51. PMID 19961857 DOI: 10.1016/J.Jmb.2009.11.057 |
0.357 |
|
| 2010 |
Harris CM, Ericsson AM, Argiriadi MA, Barberis C, Borhani DW, Burchat A, Calderwood DJ, Cunha GA, Dixon RW, Frank KE, Johnson EF, Kamens J, Kwak S, Li B, Mullen KD, et al. 2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization. Bioorganic & Medicinal Chemistry Letters. 20: 334-7. PMID 19926477 DOI: 10.1016/J.Bmcl.2009.10.103 |
0.34 |
|
| 2010 |
Johnson E, Vercollone C, Lee AT, Rees DC. Structure Dynamics and Allosteric Regulation of the E. Coli High-Affinity Methionine Transporter Metni Biophysical Journal. 98: 46a. DOI: 10.1016/J.Bpj.2009.12.267 |
0.304 |
|
| 2009 |
Tong Y, Bouska JJ, Ellis PA, Johnson EF, Leverson J, Liu X, Marcotte PA, Olson AM, Osterling DJ, Przytulinska M, Rodriguez LE, Shi Y, Soni N, Stavropoulos J, Thomas S, et al. Synthesis and evaluation of a new generation of orally efficacious benzimidazole-based poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors as anticancer agents. Journal of Medicinal Chemistry. 52: 6803-13. PMID 19888760 DOI: 10.1021/Jm900697R |
0.313 |
|
| 2009 |
Tao ZF, Hasvold LA, Leverson JD, Han EK, Guan R, Johnson EF, Stoll VS, Stewart KD, Stamper G, Soni N, Bouska JJ, Luo Y, Sowin TJ, Lin NH, Giranda VS, et al. Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases. Journal of Medicinal Chemistry. 52: 6621-36. PMID 19842661 DOI: 10.1021/Jm900943H |
0.357 |
|
| 2009 |
Miyashiro J, Woods KW, Park CH, Liu X, Shi Y, Johnson EF, Bouska JJ, Olson AM, Luo Y, Fry EH, Giranda VL, Penning TD. Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1). Bioorganic & Medicinal Chemistry Letters. 19: 4050-4. PMID 19553114 DOI: 10.1016/J.Bmcl.2009.06.016 |
0.32 |
|
| 2009 |
Penning TD, Zhu GD, Gandhi VB, Gong J, Liu X, Shi Y, Klinghofer V, Johnson EF, Donawho CK, Frost DJ, Bontcheva-Diaz V, Bouska JJ, Osterling DJ, Olson AM, Marsh KC, et al. Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer. Journal of Medicinal Chemistry. 52: 514-23. PMID 19143569 DOI: 10.1021/Jm801171J |
0.337 |
|
| 2008 |
Tong Y, Stewart KD, Thomas S, Przytulinska M, Johnson EF, Klinghofer V, Leverson J, McCall O, Soni NB, Luo Y, Lin NH, Sowin TJ, Giranda VL, Penning TD. Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: chemistry, biological activities, and molecular modeling. Bioorganic & Medicinal Chemistry Letters. 18: 5206-8. PMID 18790640 DOI: 10.1016/J.Bmcl.2008.08.079 |
0.358 |
|
| 2008 |
Kartha JS, Skordos KW, Sun H, Hall C, Easterwood LM, Reilly CA, Johnson EF, Yost GS. Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase. Biochemistry. 47: 9756-70. PMID 18717595 DOI: 10.1021/Bi8005658 |
0.308 |
|
| 2008 |
Mast N, White MA, Bjorkhem I, Johnson EF, Stout CD, Pikuleva IA. Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain. Proceedings of the National Academy of Sciences of the United States of America. 105: 9546-51. PMID 18621681 DOI: 10.1073/Pnas.0803717105 |
0.392 |
|
| 2008 |
Zhu GD, Gandhi VB, Gong J, Thomas S, Luo Y, Liu X, Shi Y, Klinghofer V, Johnson EF, Frost D, Donawho C, Jarvis K, Bouska J, Marsh KC, Rosenberg SH, et al. Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituent. Bioorganic & Medicinal Chemistry Letters. 18: 3955-8. PMID 18586490 DOI: 10.1016/J.Bmcl.2008.06.023 |
0.343 |
|
| 2008 |
Penning TD, Zhu GD, Gandhi VB, Gong J, Thomas S, Lubisch W, Grandel R, Wernet W, Park CH, Fry EH, Liu X, Shi Y, Klinghofer V, Johnson EF, Donawho CK, et al. Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. Bioorganic & Medicinal Chemistry. 16: 6965-75. PMID 18541433 DOI: 10.1016/J.Bmc.2008.05.044 |
0.34 |
|
| 2008 |
White MA, Mast N, Bjorkhem I, Johnson EF, Stout CD, Pikuleva IA. Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1. Acta Crystallographica. Section D, Biological Crystallography. 64: 487-95. PMID 18453684 DOI: 10.1107/S0907444908004046 |
0.3 |
|
| 2008 |
Showalter SA, Bruschweiler-Li L, Johnson E, Zhang F, Brüschweiler R. Quantitative lid dynamics of MDM2 reveals differential ligand binding modes of the p53-binding cleft. Journal of the American Chemical Society. 130: 6472-8. PMID 18435534 DOI: 10.1021/Ja800201J |
0.326 |
|
| 2008 |
Schoch GA, Yano JK, Sansen S, Dansette PM, Stout CD, Johnson EF. Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid. The Journal of Biological Chemistry. 283: 17227-37. PMID 18413310 DOI: 10.1074/Jbc.M802180200 |
0.618 |
|
| 2008 |
Gracias V, Ji Z, Akritopoulou-Zanze I, Abad-Zapatero C, Huth JR, Song D, Hajduk PJ, Johnson EF, Glaser KB, Marcotte PA, Pease L, Soni NB, Stewart KD, Davidsen SK, Michaelides MR, et al. Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors Bioorganic and Medicinal Chemistry Letters. 18: 2691-2695. PMID 18362070 DOI: 10.1016/J.Bmcl.2008.03.021 |
0.325 |
|
| 2007 |
Tao Z, Chen Z, Bui M, Kovar P, Johnson E, Bouska J, Zhang H, Rosenberg S, Sowin T, Lin N. Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and preliminary pharmacokinetics. Bioorganic & Medicinal Chemistry Letters. 17: 6593-6601. PMID 17935989 DOI: 10.1016/J.Bmcl.2007.09.063 |
0.355 |
|
| 2007 |
Hsu MH, Savas U, Griffin KJ, Johnson EF. Human cytochrome p450 family 4 enzymes: function, genetic variation and regulation. Drug Metabolism Reviews. 39: 515-38. PMID 17786636 DOI: 10.1080/03602530701468573 |
0.353 |
|
| 2007 |
Johnson EF, Stewart KD, Woods KW, Giranda VL, Luo Y. Pharmacological and functional comparison of the polo-like kinase family: Insight into inhibitor and substrate specificity Biochemistry. 46: 9551-9563. PMID 17655330 DOI: 10.1021/Bi7008745 |
0.334 |
|
| 2007 |
Sansen S, Hsu MH, Stout CD, Johnson EF. Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants. Archives of Biochemistry and Biophysics. 464: 197-206. PMID 17540336 DOI: 10.1016/J.Abb.2007.04.028 |
0.41 |
|
| 2007 |
Zhu GD, Gandhi VB, Gong J, Thomas S, Woods KW, Song X, Li T, Diebold RB, Luo Y, Liu X, Guan R, Klinghofer V, Johnson EF, Bouska J, Olson A, et al. Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. Journal of Medicinal Chemistry. 50: 2990-3003. PMID 17523610 DOI: 10.1021/Jm0701019 |
0.349 |
|
| 2007 |
Dinges J, Albert DH, Arnold LD, Ashworth KL, Akritopoulou-Zanze I, Bousquet PF, Bouska JJ, Cunha GA, Davidsen SK, Diaz GJ, Djuric SW, Gasiecki AF, Gintant GA, Gracias VJ, Harris CM, ... ... Johnson EF, et al. 1,4-Dihydroindeno[1,2-c]pyrazoles with acetylenic side chains as novel and potent multitargeted receptor tyrosine kinase inhibitors with low affinity for the hERG ion channel. Journal of Medicinal Chemistry. 50: 2011-29. PMID 17425296 DOI: 10.1021/Jm061223O |
0.339 |
|
| 2007 |
Tao ZF, Wang L, Stewart KD, Chen Z, Gu W, Bui MH, Merta P, Zhang H, Kovar P, Johnson E, Park C, Judge R, Rosenberg S, Sowin T, Lin NH. Structure-based design, synthesis, and biological evaluation of potent and selective macrocyclic checkpoint kinase 1 inhibitors. Journal of Medicinal Chemistry. 50: 1514-27. PMID 17352464 DOI: 10.1021/Jm061247V |
0.362 |
|
| 2007 |
Sansen S, Yano JK, Reynald RL, Schoch GA, Griffin KJ, Stout CD, Johnson EF. Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2. The Journal of Biological Chemistry. 282: 14348-55. PMID 17311915 DOI: 10.1074/Jbc.M611692200 |
0.401 |
|
| 2007 |
Zhu GD, Gong J, Gandhi VB, Woods K, Luo Y, Liu X, Guan R, Klinghofer V, Johnson EF, Stoll VS, Mamo M, Li Q, Rosenberg SH, Giranda VL. Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt. Bioorganic & Medicinal Chemistry. 15: 2441-52. PMID 17258463 DOI: 10.1016/J.Bmc.2007.01.010 |
0.351 |
|
| 2007 |
Hsu MH, Savas U, Griffin KJ, Johnson EF. Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin. The Journal of Biological Chemistry. 282: 5225-36. PMID 17142457 DOI: 10.1074/Jbc.M608176200 |
0.354 |
|
| 2006 |
Yano JK, Denton TT, Cerny MA, Zhang X, Johnson EF, Cashman JR. Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. Journal of Medicinal Chemistry. 49: 6987-7001. PMID 17125252 DOI: 10.1021/Jm060519R |
0.413 |
|
| 2006 |
Zhao H, Serby MD, Xin Z, Szczepankiewicz BG, Liu M, Kosogof C, Liu B, Nelson LT, Johnson EF, Wang S, Pederson T, Gum RJ, Clampit JE, Haasch DL, Abad-Zapatero C, et al. Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors. Journal of Medicinal Chemistry. 49: 4455-8. PMID 16854050 DOI: 10.1021/Jm060465L |
0.344 |
|
| 2006 |
Woods KW, Fischer JP, Claiborne A, Li T, Thomas SA, Zhu GD, Diebold RB, Liu X, Shi Y, Klinghofer V, Han EK, Guan R, Magnone SR, Johnson EF, Bouska JJ, et al. Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors. Bioorganic & Medicinal Chemistry. 14: 6832-46. PMID 16843670 DOI: 10.1016/J.Bmc.2006.06.047 |
0.363 |
|
| 2006 |
Szczepankiewicz BG, Kosogof C, Nelson LT, Liu G, Liu B, Zhao H, Serby MD, Xin Z, Liu M, Gum RJ, Haasch DL, Wang S, Clampit JE, Johnson EF, Lubben TH, et al. Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. Journal of Medicinal Chemistry. 49: 3563-80. PMID 16759099 DOI: 10.1021/Jm060199B |
0.331 |
|
| 2006 |
Thomas SA, Li T, Woods KW, Song X, Packard G, Fischer JP, Diebold RB, Liu X, Shi Y, Klinghofer V, Johnson EF, Bouska JJ, Olson A, Guan R, Magnone SR, et al. Identification of a novel 3,5-disubstituted pyridine as a potent, selective, and orally active inhibitor of Akt1 kinase. Bioorganic & Medicinal Chemistry Letters. 16: 3740-4. PMID 16678413 DOI: 10.1016/J.Bmcl.2006.04.046 |
0.332 |
|
| 2006 |
Albert DH, Tapang P, Magoc TJ, Pease LJ, Reuter DR, Wei RQ, Li J, Guo J, Bousquet PF, Ghoreishi-Haack NS, Wang B, Bukofzer GT, Wang YC, Stavropoulos JA, Hartandi K, ... ... Johnson EF, et al. Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor. Molecular Cancer Therapeutics. 5: 995-1006. PMID 16648571 DOI: 10.1158/1535-7163.Mct-05-0410 |
0.313 |
|
| 2006 |
Zhu GD, Gandhi VB, Gong J, Luo Y, Liu X, Shi Y, Guan R, Magnone SR, Klinghofer V, Johnson EF, Bouska J, Shoemaker A, Oleksijew A, Jarvis K, Park C, et al. Discovery and SAR of oxindole-pyridine-based protein kinase B/Akt inhibitors for treating cancers. Bioorganic & Medicinal Chemistry Letters. 16: 3424-9. PMID 16644221 DOI: 10.1016/J.Bmcl.2006.04.005 |
0.33 |
|
| 2006 |
Zhu GD, Gong J, Claiborne A, Woods KW, Gandhi VB, Thomas S, Luo Y, Liu X, Shi Y, Guan R, Magnone SR, Klinghofer V, Johnson EF, Bouska J, Shoemaker A, et al. Isoquinoline-pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity. Bioorganic & Medicinal Chemistry Letters. 16: 3150-5. PMID 16603355 DOI: 10.1016/J.Bmcl.2006.03.041 |
0.347 |
|
| 2006 |
Li Q, Woods KW, Thomas S, Zhu GD, Packard G, Fisher J, Li T, Gong J, Dinges J, Song X, Abrams J, Luo Y, Johnson EF, Shi Y, Liu X, et al. Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer. Bioorganic & Medicinal Chemistry Letters. 16: 2000-7. PMID 16413780 DOI: 10.1016/J.Bmcl.2005.12.065 |
0.349 |
|
| 2006 |
Li Q, Li T, Zhu GD, Gong J, Claibone A, Dalton C, Luo Y, Johnson EF, Shi Y, Liu X, Klinghofer V, Bauch JL, Marsh KC, Bouska JJ, Arries S, et al. Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation. Bioorganic & Medicinal Chemistry Letters. 16: 1679-85. PMID 16403626 DOI: 10.1016/J.Bmcl.2005.12.017 |
0.341 |
|
| 2005 |
Johnson EF, Stout CD. Structural diversity of human xenobiotic-metabolizing cytochrome P450 monooxygenases. Biochemical and Biophysical Research Communications. 338: 331-6. PMID 16157296 DOI: 10.1016/J.Bbrc.2005.08.190 |
0.398 |
|
| 2005 |
Yano JK, Hsu MH, Griffin KJ, Stout CD, Johnson EF. Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen. Nature Structural & Molecular Biology. 12: 822-3. PMID 16086027 DOI: 10.1038/Nsmb971 |
0.364 |
|
| 2004 |
Melet A, Marques-Soares C, Schoch GA, Macherey AC, Jaouen M, Dansette PM, Sari MA, Johnson EF, Mansuy D. Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants Biochemistry. 43: 15379-15392. PMID 15581350 DOI: 10.1021/Bi0489309 |
0.617 |
|
| 2004 |
Yano JK, Wester MR, Schoch GA, Griffin KJ, Stout CD, Johnson EF. The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution. The Journal of Biological Chemistry. 279: 38091-4. PMID 15258162 DOI: 10.1074/Jbc.C400293200 |
0.396 |
|
| 2004 |
Wester MR, Yano JK, Schoch GA, Yang C, Griffin KJ, Stout CD, Johnson EF. The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution. The Journal of Biological Chemistry. 279: 35630-7. PMID 15181000 DOI: 10.1074/Jbc.M405427200 |
0.381 |
|
| 2004 |
Scott EE, White MA, He YA, Johnson EF, Stout CD, Halpert JR. Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding. The Journal of Biological Chemistry. 279: 27294-301. PMID 15100217 DOI: 10.1074/Jbc.M403349200 |
0.392 |
|
| 2004 |
Schoch GA, Yano JK, Wester MR, Griffin KJ, Stout CD, Johnson EF. Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site. The Journal of Biological Chemistry. 279: 9497-503. PMID 14676196 DOI: 10.1074/Jbc.M312516200 |
0.407 |
|
| 2003 |
Scott EE, He YA, Wester MR, White MA, Chin CC, Halpert JR, Johnson EF, Stout CD. An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution. Proceedings of the National Academy of Sciences of the United States of America. 100: 13196-201. PMID 14563924 DOI: 10.1073/Pnas.2133986100 |
0.385 |
|
| 2003 |
Wester MR, Johnson EF, Marques-Soares C, Dijols S, Dansette PM, Mansuy D, Stout CD. Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 Å resolution: Evidence for an induced fit model of substrate binding Biochemistry. 42: 9335-9345. PMID 12899620 DOI: 10.1021/Bi034556L |
0.624 |
|
| 2003 |
Wester MR, Johnson EF, Marques-Soares C, Dansette PM, Mansuy D, Stout CD. Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 Å resolution: Evidence for multiple substrate binding modes Biochemistry. 42: 6370-6379. PMID 12767218 DOI: 10.1021/Bi0273922 |
0.617 |
|
| 2003 |
Marques-Soares C, Dijols S, Macherey AC, Wester MR, Johnson EF, Dansette PM, Mansuy D. Sulfaphenazole derivatives as tools for comparing cytochrome P450 2C5 and human cytochromes P450 2Cs: Identification of a new high affinity substrate common to those enzymes Biochemistry. 42: 6363-6369. PMID 12767217 DOI: 10.1021/Bi027391+ |
0.609 |
|
| 2003 |
Gorokhov A, Negishi M, Johnson EF, Pedersen LC, Perera L, Darden TA, Pedersen LG. Explicit water near the catalytic I helix Thr in the predicted solution structure of CYP2A4. Biophysical Journal. 84: 57-68. PMID 12524265 DOI: 10.1016/S0006-3495(03)74832-2 |
0.379 |
|
| 2003 |
Cosme J, Johnson EF. Analyzing binding of N-terminal truncated, microsomal cytochrome P450s to membranes. Methods in Enzymology. 357: 116-20. PMID 12424903 DOI: 10.1016/S0076-6879(02)57671-0 |
0.313 |
|
| 2002 |
Johnson EF, Wester MR, Stout CD. The structure of microsomal cytochrome P450 2C5: a steroid and drug metabolizing enzyme. Endocrine Research. 28: 435-41. PMID 12530646 DOI: 10.1081/Erc-120016820 |
0.403 |
|
| 2002 |
Johnson EF, Hsu MH, Savas U, Griffin KJ. Regulation of P450 4A expression by peroxisome proliferator activated receptors. Toxicology. 181: 203-6. PMID 12505311 DOI: 10.1016/S0300-483X(02)00282-2 |
0.324 |
|
| 2002 |
Cowart LA, Wei S, Hsu MH, Johnson EF, Krishna MU, Falck JR, Capdevila JH. The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands. The Journal of Biological Chemistry. 277: 35105-12. PMID 12124379 DOI: 10.1074/Jbc.M201575200 |
0.345 |
|
| 2001 |
Hsu MH, Savas U, Griffin KJ, Johnson EF. Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells. The Journal of Biological Chemistry. 276: 27950-8. PMID 11371553 DOI: 10.1074/Jbc.M100258200 |
0.304 |
|
| 2001 |
Tsao CC, Wester MR, Ghanayem B, Coulter SJ, Chanas B, Johnson EF, Goldstein JA. Identification of human CYP2C19 residues that confer S-mephenytoin 4'-hydroxylation activity to CYP2C9. Biochemistry. 40: 1937-44. PMID 11329260 DOI: 10.1021/Bi001678U |
0.378 |
|
| 2001 |
Spatzenegger M, Wang Q, He YQ, Wester MR, Johnson EF, Halpert JR. Amino acid residues critical for differential inhibition of CYP2B4, CYP2B5, and CYP2B1 by phenylimidazoles. Molecular Pharmacology. 59: 475-84. PMID 11179442 DOI: 10.1124/Mol.59.3.475 |
0.383 |
|
| 2001 |
Williams PA, Cosme J, Sridhar V, Johnson EF, McRee DE. Microsomal cytochrome P450 2C5: comparison to microbial P450s and unique features. Journal of Inorganic Biochemistry. 81: 183-90. PMID 11051563 DOI: 10.1016/S0162-0134(00)00102-1 |
0.358 |
|
| 2000 |
Mukhopadhyay B, Johnson EF, Wolfe RS. A novel pH2 control on the expression of flagella in the hyperthermophilic strictly hydrogenotrophic methanarchaeaon Methanococcus jannaschii. Proceedings of the National Academy of Sciences of the United States of America. 97: 11522-7. PMID 11027352 DOI: 10.1073/Pnas.97.21.11522 |
0.304 |
|
| 2000 |
Williams PA, Cosme J, Sridhar V, Johnson EF, McRee DE. Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity. Molecular Cell. 5: 121-31. PMID 10678174 DOI: 10.1016/S1097-2765(00)80408-6 |
0.363 |
|
| 2000 |
Cosme J, Johnson EF. Engineering microsomal cytochrome P450 2C5 to be a soluble, monomeric enzyme. Mutations that alter aggregation, phospholipid dependence of catalysis, and membrane binding. The Journal of Biological Chemistry. 275: 2545-53. PMID 10644712 DOI: 10.1074/Jbc.275.4.2545 |
0.379 |
|
| 1999 |
Savas U, Griffin KJ, Johnson EF. Molecular mechanisms of cytochrome P-450 induction by xenobiotics: An expanded role for nuclear hormone receptors. Molecular Pharmacology. 56: 851-7. PMID 10531387 DOI: 10.1124/Mol.56.5.851 |
0.329 |
|
| 1998 |
Jung F, Griffin KJ, Song W, Richardson TH, Yang M, Johnson EF. Identification of amino acid substitutions that confer a high affinity for sulfaphenazole binding and a high catalytic efficiency for warfarin metabolism to P450 2C19 Biochemistry. 37: 16270-16279. PMID 9819219 DOI: 10.1021/Bi981704C |
0.363 |
|
| 1998 |
Dierks EA, Zhang Z, Johnson EF, de Montellano PR. The catalytic site of cytochrome P4504A11 (CYP4A11) and its L131F mutant. The Journal of Biological Chemistry. 273: 23055-61. PMID 9722531 DOI: 10.1074/Jbc.273.36.23055 |
0.371 |
|
| 1998 |
Palmer CNA, Hsu M, Griffin KJ, Raucy JL, Johnson EF. Peroxisome Proliferator Activated Receptor-α Expression in Human Liver Molecular Pharmacology. 53: 14-22. DOI: 10.1124/Mol.53.1.14 |
0.32 |
|
| 1997 |
Von Wachenfeldt C, Richardson TH, Cosme J, Johnson EF. Microsomal P450 2C3 is expressed as a soluble dimer in Escherichia coli following modifications of its N-terminus Archives of Biochemistry and Biophysics. 339: 107-114. PMID 9056240 DOI: 10.1006/Abbi.1996.9859 |
0.335 |
|
| 1997 |
Richardson TH, Griffin KJ, Jung F, Raucy JL, Johnson EF. Targeted antipeptide antibodies to cytochrome P450 2C18 based on epitope mapping of an inhibitory monoclonal antibody to P450 2C5 Archives of Biochemistry and Biophysics. 338: 157-164. PMID 9028867 DOI: 10.1006/Abbi.1996.9817 |
0.342 |
|
| 1996 |
Johnson EF, Palmer CN, Griffin KJ, Hsu MH. Role of the peroxisome proliferator-activated receptor in cytochrome P450 4A gene regulation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 10: 1241-8. PMID 8836037 DOI: 10.1096/Fasebj.10.11.8836037 |
0.329 |
|
| 1995 |
Richardson TH, Jung F, Griffin KJ, Wester M, Raucy JL, Kemper B, Bornheim LM, Hassett C, Omiecinski CJ, Johnson EF. A universal approach to the expression of human and rabbit cytochrome P450s of the 2C subfamily in Escherichia coli Archives of Biochemistry and Biophysics. 323: 87-96. PMID 7487078 DOI: 10.1006/Abbi.1995.0013 |
0.358 |
|
| 1994 |
Straub P, Lloyd M, Johnson EF, Kemper B. Differential effects of mutations in substrate recognition site 1 of cytochrome P450 2C2 on lauric acid and progesterone hydroxylation. Biochemistry. 33: 8029-34. PMID 8025107 DOI: 10.1021/Bi00192A006 |
0.387 |
|
| 1993 |
Richardson TH, Hsu MH, Kronbach T, Barnes HJ, Chan G, Waterman MR, Kemper B, Johnson EF. Purification and characterization of recombinant-expressed cytochrome P450 2C3 from Escherichia coli: 2C3 encodes the 6β-hydroxylase deficient form of P450 3b Archives of Biochemistry and Biophysics. 300: 510-516. PMID 8380971 DOI: 10.1006/Abbi.1993.1069 |
0.352 |
|
| 1993 |
Straub P, Johnson EF, Kemper B. Hydrophobic side chain requirements for lauric acid and progesterone hydroxylation at amino acid 113 in cytochrome P450 2C2, a potential determinant of substrate specificity. Archives of Biochemistry and Biophysics. 306: 521-7. PMID 8215458 DOI: 10.1006/Abbi.1993.1547 |
0.354 |
|
| 1993 |
Palmer CN, Richardson TH, Griffin KJ, Hsu MH, Muerhoff AS, Clark JE, Johnson EF. Characterization of a cDNA encoding a human kidney, cytochrome P-450 4A fatty acid omega-hydroxylase and the cognate enzyme expressed in Escherichia coli. Biochimica Et Biophysica Acta. 1172: 161-6. PMID 7679927 DOI: 10.1016/0167-4781(93)90285-L |
0.352 |
|
| 1992 |
Manns MP, Johnson EF. Identification of human cytochrome P450s as autoantigens. Methods in Enzymology. 206: 210-20. PMID 1784210 DOI: 10.1016/0076-6879(91)06092-H |
0.335 |
|
| 1992 |
Johnson EF. Mapping determinants of the substrate selectivities of P450 enzymes by site-directed mutagenesis. Trends in Pharmacological Sciences. 13: 122-6. PMID 1574808 DOI: 10.1016/0165-6147(92)90042-5 |
0.376 |
|
| 1992 |
Johnson EF, Kronbach T, Hsu MH. Analysis of the catalytic specificity of cytochrome P450 enzymes through site-directed mutagenesis Faseb Journal. 6: 700-705. PMID 1537459 DOI: 10.1096/Fasebj.6.2.1537459 |
0.4 |
|
| 1991 |
Kronbach T, Kemper B, Johnson EF. A hypervariable region of P450IIC5 confers progesterone 21-hydroxylase activity to P450IIC1. Biochemistry. 30: 6097-102. PMID 2059619 DOI: 10.1021/Bi00239A003 |
0.382 |
|
| 1990 |
Manns MP, Griffin KJ, Quattrochi LC, Sacher M, Thaler H, Tukey RH, Johnson EF. Identification of cytochrome P450IA2 as a human autoantigen. Archives of Biochemistry and Biophysics. 280: 229-32. PMID 2353823 DOI: 10.1016/0003-9861(90)90541-6 |
0.34 |
|
| 1990 |
Johnson EF, Walker DL, Griffin KJ, Clark JE, Okita RT, Muerhoff AS, Masters BS. Cloning and expression of three rabbit kidney cDNAs encoding lauric acid omega-hydroxylases. Biochemistry. 29: 873-9. PMID 2340280 DOI: 10.1021/Bi00456A004 |
0.34 |
|
| 1990 |
Trant JM, Lorence MC, Johnson EF, Shackleton CH, Mason JI, Estabrook RW. Characterization of the steroid-metabolizing capacity of the hepatic cytochrome P450IIC5 expressed in COS-1 cells: 3 beta-hydroxysteroid dehydrogenase/delta 5----4 isomerase type activity. Proceedings of the National Academy of Sciences of the United States of America. 87: 9756-60. PMID 2148210 DOI: 10.1073/Pnas.87.24.9756 |
0.326 |
|
| 1989 |
Kronbach T, Larabee TM, Johnson EF. Hybrid cytochromes P-450 identify a substrate binding domain in P-450IIC5 and P-450IIC4. Proceedings of the National Academy of Sciences of the United States of America. 86: 8262-5. PMID 2813390 DOI: 10.1073/Pnas.86.21.8262 |
0.409 |
|
| 1989 |
Halpert JR, Jaw JY, Johnson EF. Design of specific mechanism-based inactivators of hepatic and adrenal microsomal cytochromes P-450 responsible for progesterone 21-hydroxylation. Drug Metabolism Reviews. 20: 645-55. PMID 2680401 DOI: 10.3109/03602538909103567 |
0.314 |
|
| 1988 |
Halpert J, Jaw JY, Balfour C, Mash EA, Johnson EF. Selective inactivation by 21-chlorinated steroids of rabbit liver and adrenal microsomal cytochromes P-450 involved in progesterone hydroxylation. Archives of Biochemistry and Biophysics. 264: 462-71. PMID 3261153 DOI: 10.1016/0003-9861(88)90311-6 |
0.401 |
|
| 1987 |
Finlayson MJ, Kemper B, Browne N, Johnson EF. Evidence that rabbit cytochrome P-450 K is encoded by the plasmid pP-450 PBc2. Biochemical and Biophysical Research Communications. 141: 728-33. PMID 3801023 DOI: 10.1016/S0006-291X(86)80233-9 |
0.323 |
|
| 1987 |
Johnson EF, Finlayson M, Raucy J, Barnes H, Schwab GE, Griffin KJ, Tukey RH. Intraspecies individuality for the metabolism of steroids Xenobiotica. 17: 275-285. PMID 3577205 DOI: 10.3109/00498258709043938 |
0.365 |
|
| 1987 |
Finlayson MJ, Dees JH, Masters BS, Johnson EF. Differential expression of cytochrome P-450 1 and related forms in rabbit liver and kidney. Archives of Biochemistry and Biophysics. 252: 113-20. PMID 3492962 DOI: 10.1016/0003-9861(87)90014-2 |
0.354 |
|
| 1985 |
McManus ME, Minchin RF, Sanderson N, Schwartz D, Johnson EF, Thorgeirsson SS. Metabolic processing of 2-acetylaminofluorene by microsomes and six highly purified cytochrome P-450 forms from rabbit liver. Carcinogenesis. 5: 1717-23. PMID 6499123 DOI: 10.1093/Carcin/5.12.1717 |
0.371 |
|
| 1985 |
Schwab GE, Johnson EF. Two catalytically distinct subforms of cytochrome P-450 3b as obtained from inbred rabbits Biochemistry. 24: 7222-7226. PMID 4084577 DOI: 10.1021/Bi00346A030 |
0.336 |
|
| 1985 |
Schwab GE, Johnson EF. Variation in hepatic microsomal cytochrome P-450 1 concentration among untreated rabbits alters the efficiency of estradiol hydroxylation Archives of Biochemistry and Biophysics. 237: 17-26. PMID 3970543 DOI: 10.1016/0003-9861(85)90249-8 |
0.37 |
|
| 1985 |
Johnson EF, Griffin KJ. Variations in hepatic progesterone 21-hydroxylase activity reflect differences in the microsomal concentration of rabbit cytochrome P-450 1 Archives of Biochemistry and Biophysics. 237: 55-64. PMID 3871600 DOI: 10.1016/0003-9861(85)90253-X |
0.367 |
|
| 1985 |
Okino ST, Quattrochi LC, Barnes HJ, Osanto S, Griffin KJ, Johnson EF, Tukey RH. Cloning and characterization of cDNAs encoding 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible rabbit mRNAs for cytochrome P-450 isozymes 4 and 6 Proceedings of the National Academy of Sciences of the United States of America. 82: 5310-5314. PMID 2991917 DOI: 10.1073/Pnas.82.16.5310 |
0.338 |
|
| 1984 |
Johnson EF, Schwab GE. Constitutive forms of rabbit-liver microsomal cytochrome p-450: Enzymatic diversity, polymorphism and allosteric regulation Xenobiotica. 14: 3-18. PMID 6609490 DOI: 10.3109/00498258409151395 |
0.385 |
|
| 1984 |
Reubi I, Griffin KJ, Raucy J, Johnson EF. Use of a monoclonal antibody specific for rabbit microsomal cytochrome P-450 3b to characterize the participation of this cytochrome in the microsomal 6 beta- and 16 alpha-hydroxylation of progesterone. Biochemistry. 23: 4598-603. PMID 6208936 DOI: 10.1021/Bi00315A013 |
0.328 |
|
| 1983 |
Johnson EF, Shiverick KT. Differences in the regiospecific metabolism of testosterone as catalyzed by variant forms of rabbit microsomal cytochrome P-450 3b. Biochemical and Biophysical Research Communications. 109: 786-91. PMID 7159441 DOI: 10.1016/0006-291X(82)92008-3 |
0.341 |
|
| 1983 |
Liem HH, Johnson EF, Muller-Eberhard U. The effect in vivo and in vitro of allylisopropylacetamide on the content of hepatic microsomal cytochrome P-450 2 of phenobarbital treated rabbits. Biochemical and Biophysical Research Communications. 111: 926-32. PMID 6838593 DOI: 10.1016/0006-291X(83)91388-8 |
0.355 |
|
| 1982 |
Dieter HH, Muller-Eberhard U, Johnson EF. Identification of rabbit microsomal cytochrome P-450 isozyme, form 1, as a hepatic progesterone 21-hydroxylase. Biochemical and Biophysical Research Communications. 105: 515-20. PMID 6980002 DOI: 10.1016/0006-291X(82)91465-6 |
0.343 |
|
| 1980 |
Norman RL, Johnson EF, Müller-Eberhard U. Cytochrome P-450 Form 4, A Major Determinant Of 2-Aminoanthracene Mutagenesis Microsomes, Drug Oxidations and Chemical Carcinogenesis. 1161-1164. DOI: 10.1016/B978-0-12-187702-6.50104-3 |
0.358 |
|
| 1980 |
Johnson EF. Contrasting Properties Of Microsomal Cytochrome P-450: Characterization Of A Constitutive Form Of The Cytochrome Microsomes, Drug Oxidations and Chemical Carcinogenesis. 143-146. DOI: 10.1016/B978-0-12-187701-9.50026-7 |
0.354 |
|
| 1979 |
Johnson EF, Zounes MC, Muller-Eberhard U. Characterization of three forms of rabbit microsomal cytochrome P-450 by peptide mapping utilizing limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. Archives of Biochemistry and Biophysics. 192: 282-9. PMID 434823 DOI: 10.1016/0003-9861(79)90093-6 |
0.316 |
|
| 1979 |
Norman RL, Muller-Eberhard U, Johnson EF. The role of cytochrome P-450 forms in 2-aminoanthracene and benz[α]pyrene mutagenesis Biochemical and Biophysical Research Communications. 89: 195-201. PMID 383076 DOI: 10.1016/0006-291X(79)90963-X |
0.352 |
|
| 1977 |
Johnson EF, Muller-Eberhard U. Purification of the major cytochrome P-450 of liver microsomes from rabbits treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Biochemical and Biophysical Research Communications. 76: 652-9. PMID 409393 DOI: 10.1016/0006-291X(77)91550-9 |
0.356 |
|
| 1977 |
Johnson EF, Muller-Eberhard U. Multiple forms of cytochrome P-450: resolution and purification of rabbit liver aryl hydrocarbon hydroxylase. Biochemical and Biophysical Research Communications. 76: 644-51. PMID 409392 DOI: 10.1016/0006-291X(77)91549-2 |
0.376 |
|
| 1973 |
Johnson EF, Drago RS. Reorientational correlation functions obtained from Raman line shapes Journal of the American Chemical Society. 95: 1391-1398. DOI: 10.1021/Ja00786A007 |
0.414 |
|
| 1973 |
JOHNSON EF, DRAGO RS. ChemInform Abstract: AUS RAMAN-LINIENPROFILEN ERHALTENE REORIENTIERUNGS-KORRELATIONSFUNKTIONEN Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/Chin.197319060 |
0.405 |
|
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