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Stephen J. Elledge - Publications

Affiliations: 
1989-2003 Baylor College of Medicine, Houston, TX 
 2003- Genetics Harvard Medical School, Boston, MA, United States 
Area:
response to DNA damage and regulation of the cell cycle
Website:
http://genetics.med.harvard.edu/faculty/elledge
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314 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Dezfulian MH, Kula T, Pranzatelli T, Kamitaki N, Meng Q, Khatri B, Perez P, Xu Q, Chang A, Kohlgruber AC, Leng Y, Jupudi AA, Joachims ML, Chiorini JA, Lessard CJ, ... ... Elledge SJ, et al. TScan-II: A genome-scale platform for the de novo identification of CD4 T cell epitopes. Cell. PMID 38016469 DOI: 10.1016/j.cell.2023.10.024  0.68
2023 Zhang Z, Sie B, Chang A, Leng Y, Nardone C, Timms RT, Elledge SJ. Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping. Molecular Cell. 83: 4191-4192. PMID 37977122 DOI: 10.1016/j.molcel.2023.10.021  0.668
2023 Zhang Z, Sie B, Chang A, Leng Y, Nardone C, Timms RT, Elledge SJ. Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping. Molecular Cell. 83: 3377-3392.e6. PMID 37738965 DOI: 10.1016/j.molcel.2023.08.022  0.699
2022 Li S, Qian N, Jiang C, Zu W, Liang A, Li M, Elledge SJ, Tan X. Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation. Nature Communications. 13: 105. PMID 35013224 DOI: 10.1038/s41467-021-27670-1  0.436
2021 Adeyemi RO, Willis NA, Elia AEH, Clairmont C, Li S, Wu X, D'Andrea AD, Scully R, Elledge SJ. The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair. Molecular Cell. PMID 34597596 DOI: 10.1016/j.molcel.2021.09.008  0.324
2020 Morgenlander WR, Henson S, Monaco D, Chen A, Littlefield K, Bloch EM, Fujimura E, Ruczinski I, Crowley AR, Natarajan H, Butler SE, Weiner JA, Li MZ, Bonny TS, Benner SE, ... ... Elledge SJ, et al. Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality. Medrxiv : the Preprint Server For Health Sciences. PMID 33354688 DOI: 10.1101/2020.12.16.20248294  0.637
2020 Shrock E, Fujimura E, Kula T, Timms RT, Lee IH, Leng Y, Robinson ML, Sie BM, Li MZ, Chen Y, Logue J, Zuiani A, McCulloch D, Lelis FJN, Henson S, ... ... Elledge SJ, et al. Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity. Science (New York, N.Y.). PMID 32994364 DOI: 10.1126/science.abd4250  0.64
2020 Guerra SL, Maertens O, Kuzmickas R, De Raedt T, Adeyemi RO, Guild CJ, Guillemette S, Redig AJ, Chambers ES, Xu M, Tiv H, Santagata S, Jänne PA, Elledge SJ, Cichowski K. A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers. Cancer Cell. PMID 32243838 DOI: 10.1016/J.Ccell.2020.03.004  0.389
2020 Bruno PM, Lu M, Dennis KA, Inam H, Moore CJ, Sheehe J, Elledge SJ, Hemann MT, Pritchard JR. The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning. Proceedings of the National Academy of Sciences of the United States of America. PMID 32041867 DOI: 10.1073/Pnas.1921649117  0.336
2019 Heo JM, Harper NJ, Paulo JA, Li M, Xu Q, Coughlin M, Elledge SJ, Harper JW. Integrated proteogenetic analysis reveals the landscape of a mitochondrial-autophagosome synapse during PARK2-dependent mitophagy. Science Advances. 5: eaay4624. PMID 31723608 DOI: 10.1126/Sciadv.Aay4624  0.31
2019 Mina MJ, Kula T, Leng Y, Li M, de Vries RD, Knip M, Siljander H, Rewers M, Choy DF, Wilson MS, Larman HB, Nelson AN, Griffin DE, de Swart RL, Elledge SJ. Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens. Science (New York, N.Y.). 366: 599-606. PMID 31672891 DOI: 10.1126/Science.Aay6485  0.656
2019 Elman JS, Ni TK, Mengwasser KE, Jin D, Wronski A, Elledge SJ, Kuperwasser C. Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing. Cell Reports. 28: 3435-3449.e5. PMID 31553912 DOI: 10.1016/J.Celrep.2019.08.060  0.36
2019 Kong W, Hayashi T, Fiches G, Xu Q, Li M, Que J, Liu S, Zhang W, Qi J, Santoso N, Elledge SJ, Zhu J. Diversified Application of Barcoded PLATO (PLATO-BC) Platform for Identification of Protein Interactions. Genomics, Proteomics & Bioinformatics. PMID 31494268 DOI: 10.1016/J.Gpb.2018.12.010  0.471
2019 Irving AT, Rozario P, Kong PS, Luko K, Gorman JJ, Hastie ML, Chia WN, Mani S, Lee BP, Smith GJD, Mendenhall IH, Larman HB, Elledge SJ, Wang LF. Robust dengue virus infection in bat cells and limited innate immune responses coupled with positive serology from bats in IndoMalaya and Australasia. Cellular and Molecular Life Sciences : Cmls. PMID 31352533 DOI: 10.1007/S00018-019-03242-X  0.674
2019 Zirin J, Ni X, Sack LM, Yang-Zhou D, Hu Y, Brathwaite R, Bulyk ML, Elledge SJ, Perrimon N. Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 31262815 DOI: 10.1073/Pnas.1821863116  0.386
2019 Eshleman SH, Laeyendecker O, Kammers K, Chen A, Sivay MV, Kottapalli S, Sie BM, Yuan T, Monaco DR, Mohan D, Wansley D, Kula T, Morrison C, Elledge SJ, Brookmeyer R, et al. Comprehensive Profiling of HIV Antibody Evolution. Cell Reports. 27: 1422-1433.e4. PMID 31042470 DOI: 10.1016/J.Celrep.2019.03.097  0.757
2019 Barber KW, Elledge SJ. Sequencer Hacking Unlocks Quantitative Protein Studies. Molecular Cell. 73: 863-865. PMID 30849392 DOI: 10.1016/J.Molcel.2019.01.039  0.323
2019 Maertens O, Kuzmickas R, Manchester HE, Emerson CE, Gavin AG, Guild CJ, Wong TC, De Raedt T, Bowman-Colin C, Hatchi E, Garraway LA, Flaherty KT, Pathania S, Elledge SJ, Cichowski K. MAPK pathway suppression unmasks latent DNA repair defects and confers a chemical synthetic vulnerability in BRAF, NRAS, and NF1 mutant melanomas. Cancer Discovery. PMID 30709805 DOI: 10.1158/2159-8290.Cd-18-0879  0.392
2019 Mengwasser KE, Adeyemi RO, Leng Y, Choi MY, Clairmont C, D'Andrea AD, Elledge SJ. Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. Molecular Cell. PMID 30686591 DOI: 10.1016/J.Molcel.2018.12.008  0.416
2019 Maertens O, Kuzmickas R, Manchester H, Emerson C, Gavin A, Guild C, Wong T, Raedt TD, Bowman-Colin C, Hatchi E, Garraway L, Flaherty K, Pathania S, Elledge S, Cichowski K. Abstract LB-113: MAPK pathway suppression unmasks latent DNA repair defects and confers a chemical synthetic vulnerability inBRAF,NRASandNF1-mutant melanomas Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-Lb-113  0.371
2018 Rousseaux MWC, Vázquez-Vélez GE, Al-Ramahi I, Jeong HH, Bajic A, Revelli JP, Ye H, Phan ET, Deger JM, Perez AM, Kim JY, Lavery LA, Xu Q, Li MZ, Kang H, ... ... Elledge SJ, et al. A druggable genome screen identifies modifiers of α-synuclein levels via a tiered cross-species validation approach. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30249792 DOI: 10.1523/Jneurosci.0254-18.2018  0.63
2018 Liao S, Maertens O, Cichowski K, Elledge SJ. Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is. Genes & Development. PMID 30135075 DOI: 10.1101/Gad.315648.118  0.355
2018 Koren I, Timms RT, Kula T, Xu Q, Li MZ, Elledge SJ. The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons. Cell. PMID 29779948 DOI: 10.1016/J.Cell.2018.04.028  0.332
2018 Lin HC, Yeh CW, Chen YF, Lee TT, Hsieh PY, Rusnac DV, Lin SY, Elledge SJ, Zheng N, Yen HS. C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases. Molecular Cell. 70: 602-613.e3. PMID 29775578 DOI: 10.1016/J.Molcel.2018.04.006  0.475
2018 Sack LM, Davoli T, Li MZ, Li Y, Xu Q, Naxerova K, Wooten EC, Bernardi RJ, Martin TD, Chen T, Leng Y, Liang AC, Scorsone KA, Westbrook TF, Wong KK, ... Elledge SJ, et al. Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns. Cell. PMID 29576454 DOI: 10.1016/J.Cell.2018.02.037  0.679
2018 Brumbaugh J, Di Stefano B, Wang X, Borkent M, Forouzmand E, Clowers KJ, Ji F, Schwarz BA, Kalocsay M, Elledge SJ, Chen Y, Sadreyev RI, Gygi SP, Hu G, Shi Y, et al. Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling. Cell. 172: 629-631. PMID 29373832 DOI: 10.1016/j.cell.2017.12.035  0.456
2017 Mazzucco AE, Smogorzewska A, Kang C, Luo J, Schlabach MR, Xu Q, Patel R, Elledge SJ. Corrigendum: Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program. Genes & Development. 31: 2310. PMID 29284711 DOI: 10.1101/gad.309864.117  0.571
2017 Brumbaugh J, Di Stefano B, Wang X, Borkent M, Forouzmand E, Clowers KJ, Ji F, Schwarz BA, Kalocsay M, Elledge SJ, Chen Y, Sadreyev RI, Gygi SP, Hu G, Shi Y, et al. Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling. Cell. PMID 29249356 DOI: 10.1016/J.Cell.2017.11.023  0.564
2017 Mazzucco AE, Smogorzewska A, Kang C, Luo J, Schlabach MR, Xu Q, Patel R, Elledge SJ. Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program. Genes & Development. 31: 1933-1938. PMID 29089421 DOI: 10.1101/Gad.304857.117  0.669
2017 Martin TD, Cook DR, Choi MY, Li MZ, Haigis KM, Elledge SJ. A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. Cell Reports. 20: 427-438. PMID 28700943 DOI: 10.1016/J.Celrep.2017.06.061  0.318
2017 Liao S, Davoli T, Leng Y, Li MZ, Xu Q, Elledge SJ. A genetic interaction analysis identifies cancer drivers that modify EGFR dependency. Genes & Development. PMID 28167502 DOI: 10.1101/Gad.291948.116  0.341
2016 Davoli T, Mengwasser KE, Duan J, Chen T, Christensen C, Wooten EC, Anselmo AN, Li MZ, Wong KK, Kahle KT, Elledge SJ. Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover. Genes & Development. 30: 2684-2695. PMID 28087713 DOI: 10.1101/Gad.290122.116  0.605
2016 Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MI, Duan J, Zhang J, Duran D, Alper SL, ... ... Elledge SJ, et al. Functional kinomics establishes a critical node of volume-sensitive cation-Cl(-) cotransporter regulation in the mammalian brain. Scientific Reports. 6: 35986. PMID 27782176 DOI: 10.1038/Srep35986  0.668
2016 Sack LM, Davoli T, Xu Q, Li M, Elledge SJ. Sources of Error in Mammalian Genetic Screens. G3 (Bethesda, Md.). PMID 27402361 DOI: 10.1534/G3.116.030973  0.362
2016 Zhou C, Elia AE, Naylor ML, Dephoure N, Ballif BA, Goel G, Xu Q, Ng A, Chou DM, Xavier RJ, Gygi SP, Elledge SJ. Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks. Proceedings of the National Academy of Sciences of the United States of America. PMID 27298372 DOI: 10.1073/Pnas.1602827113  0.422
2016 Willis NA, Zhou C, Elia AE, Murray JM, Carr AM, Elledge SJ, Rhind N. Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks. Proceedings of the National Academy of Sciences of the United States of America. PMID 27298342 DOI: 10.1073/Pnas.1525620113  0.421
2016 Borkent M, Bennett BD, Lackford B, Bar-Nur O, Brumbaugh J, Wang L, Du Y, Fargo DC, Apostolou E, Cheloufi S, Maherali N, Elledge SJ, Hu G, Hochedlinger K. A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2. Stem Cell Reports. PMID 26947976 DOI: 10.1016/J.Stemcr.2016.02.004  0.555
2016 Wang Y, Xu Q, Sack L, Kang C, Elledge SJ. A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling. Genes & Development. 30: 293-306. PMID 26833729 DOI: 10.1101/Gad.271445.115  0.634
2016 Davoli T, Uno H, Xu A, Mengwasser K, Sack L, Park PJ, Elledge SJ. Abstract SY10-01: How aneuploidy drives cancer Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Sy10-01  0.327
2015 Elia AE, Wang DC, Willis NA, Boardman AP, Hajdu I, Adeyemi RO, Lowry E, Gygi SP, Scully R, Elledge SJ. RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks. Molecular Cell. 60: 280-93. PMID 26474068 DOI: 10.1016/J.Molcel.2015.09.011  0.428
2015 Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ. The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science (New York, N.Y.). 349: aaa5612. PMID 26404840 DOI: 10.1126/Science.Aaa5612  0.37
2015 Huang H, Santoso N, Power D, Simpson S, Dieringer M, Miao H, Gurova K, Giam CZ, Elledge S, Zhu J. FACT Proteins, SUPT16H and SSRP1, are Transcriptional Suppressors of HIV-1 and HTLV-1 that Facilitate Viral Latency. The Journal of Biological Chemistry. PMID 26378236 DOI: 10.1074/Jbc.M115.652339  0.423
2015 Elledge SJ. Accidents and Damage Control. Cell. 162: 1196-200. PMID 26359977 DOI: 10.1016/J.Cell.2015.08.042  0.389
2015 Elledge SJ. The DNA Damage Response--Self-awareness for DNA: The 2015 Albert Lasker Basic Medical Research Award. Jama. 314: 1111-2. PMID 26348099 DOI: 10.1001/Jama.2015.10387  0.328
2015 Elia AE, Boardman AP, Wang DC, Huttlin EL, Everley RA, Dephoure N, Zhou C, Koren I, Gygi SP, Elledge SJ. Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response. Molecular Cell. PMID 26051181 DOI: 10.1016/J.Molcel.2015.05.006  0.397
2015 Xu GJ, Kula T, Xu Q, Li MZ, Vernon SD, Ndung'u T, Ruxrungtham K, Sanchez J, Brander C, Chung RT, O'Connor KC, Walker B, Larman HB, Elledge SJ. Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome. Science (New York, N.Y.). 348: aaa0698. PMID 26045439 DOI: 10.1126/Science.Aaa0698  0.684
2015 Izhar L, Adamson B, Ciccia A, Lewis J, Pontano-Vaites L, Leng Y, Liang AC, Westbrook TF, Harper JW, Elledge SJ. A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors. Cell Reports. 11: 1486-500. PMID 26004182 DOI: 10.1016/J.Celrep.2015.04.053  0.808
2015 Gao J, Kim HM, Elia AE, Elledge SJ, Colaiácovo MP. NatB domain-containing CRA-1 antagonizes hydrolase ACER-1 linking acetyl-CoA metabolism to the initiation of recombination during C. elegans meiosis. Plos Genetics. 11: e1005029. PMID 25768301 DOI: 10.1371/Journal.Pgen.1005029  0.336
2015 Ceccaldi R, Liu JC, Amunugama R, Hajdu I, Primack B, Petalcorin MI, O'Connor KW, Konstantinopoulos PA, Elledge SJ, Boulton SJ, Yusufzai T, D'Andrea AD. Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair. Nature. 518: 258-62. PMID 25642963 DOI: 10.1038/Nature14184  0.447
2015 Westbrook TF, Nair A, Sun T, Karlin KL, Kessler J, Migliaccio I, Nguyen DX, Bernardi RJ, Renwick A, Creighton CJ, Dephoure N, Gygi SP, Shaw CA, Gibbs R, Wheeler D, ... ... Elledge SJ, et al. Abstract P6-11-01: A broad spectrum therapeutic strategy for TNBC revealed by a new pathway that coordinates oncogenic RTKs Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P6-11-01  0.678
2014 Ciccia A, Huang JW, Izhar L, Sowa ME, Harper JW, Elledge SJ. Treacher Collins syndrome TCOF1 protein cooperates with NBS1 in the DNA damage response. Proceedings of the National Academy of Sciences of the United States of America. 111: 18631-6. PMID 25512513 DOI: 10.1073/Pnas.1422488112  0.792
2014 Wang R, Persky NS, Yoo B, Ouerfelli O, Smogorzewska A, Elledge SJ, Pavletich NP. DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1. Science (New York, N.Y.). 346: 1127-30. PMID 25430771 DOI: 10.1126/Science.1258973  0.669
2014 Zhu J, Davoli T, Perriera JM, Chin CR, Gaiha GD, John SP, Sigiollot FD, Gao G, Xu Q, Qu H, Pertel T, Sims JS, Smith JA, Baker RE, Maranda L, ... ... Elledge SJ, et al. Comprehensive identification of host modulators of HIV-1 replication using multiple orthologous RNAi reagents. Cell Reports. 9: 752-66. PMID 25373910 DOI: 10.1016/J.Celrep.2014.09.031  0.43
2014 Seo M, Lee S, Kim JH, Lee WH, Hu G, Elledge SJ, Suk K. RNAi-based functional selection identifies novel cell migration determinants dependent on PI3K and AKT pathways. Nature Communications. 5: 5217. PMID 25347953 DOI: 10.1038/Ncomms6217  0.593
2014 Tan X, Elledge SJ. When noise makes music: HIV reactivation with transcriptional noise enhancers. Genome Medicine. 6: 55. PMID 25276233 DOI: 10.1186/S13073-014-0055-9  0.439
2014 Finton KA, Friend D, Jaffe J, Gewe M, Holmes MA, Larman HB, Stuart A, Larimore K, Greenberg PD, Elledge SJ, Stamatatos L, Strong RK. Ontogeny of recognition specificity and functionality for the broadly neutralizing anti-HIV antibody 4E10. Plos Pathogens. 10: e1004403. PMID 25254371 DOI: 10.1371/Journal.Ppat.1004403  0.67
2014 Olive AJ, Haff MG, Emanuele MJ, Sack LM, Barker JR, Elledge SJ, Starnbach MN. Chlamydia trachomatis-induced alterations in the host cell proteome are required for intracellular growth. Cell Host & Microbe. 15: 113-24. PMID 24439903 DOI: 10.1016/J.Chom.2013.12.009  0.671
2014 Larman HB, Liang AC, Elledge SJ, Zhu J. Discovery of protein interactions using parallel analysis of translated ORFs (PLATO) Nature Protocols. 9: 90-103. PMID 24336473 DOI: 10.1038/Nprot.2013.167  0.725
2014 Kahle KT, Gao G, Zhang J, Latremoliere A, Andrews N, Shang Y, Alessi D, Woolf C, Elledge S, Clapham D. Ronald R. Tasker Young Investigator Award 165 Promoting Endogenous GABAergic Analgesia via Kinase Modulation of Neuronal Ion Plasticity Neurosurgery. 61: 214. DOI: 10.1227/01.Neu.0000452440.75411.82  0.672
2014 Davoli T, Xu W, Park P, Elledge SJ. Abstract SY36-03: How aneuploidy drives tumorigenesis Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Sy36-03  0.326
2014 Davoli T, Xu AW, Mengwasser KE, Sack LM, Yoon JC, Park PJ, Elledge SJ. Abstract 2404: Cumulative dosage effect of TSGs and OGs drives aneuploidy patterns in cancer Cancer Research. 74: 2404-2404. DOI: 10.1158/1538-7445.Am2014-2404  0.326
2014 Wang R, Persky NS, Yoo B, Ouerfelli O, Smogorzewska A, Elledge SJ, Pavletich NP. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1 Science. 346: 1127-1130. DOI: 10.1126/science.1258973  0.612
2013 Davoli T, Xu AW, Mengwasser KE, Sack LM, Yoon JC, Park PJ, Elledge SJ. Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell. 155: 948-62. PMID 24183448 DOI: 10.1016/J.Cell.2013.10.011  0.328
2013 Finton KAK, Larimore K, Larman HB, Friend D, Correnti C, Rupert PB, Elledge SJ, Greenberg PD, Strong RK. Autoreactivity and Exceptional CDR Plasticity (but Not Unusual Polyspecificity) Hinder Elicitation of the Anti-HIV Antibody 4E10 Plos Pathogens. 9. PMID 24086134 DOI: 10.1371/Journal.Ppat.1003639  0.674
2013 Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DA. Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells. Stem Cells (Dayton, Ohio). 31: 2833-41. PMID 23765749 DOI: 10.1002/Stem.1445  0.558
2013 Pavlova NN, Pallasch C, Elia AE, Braun CJ, Westbrook TF, Hemann M, Elledge SJ. A role for PVRL4-driven cell-cell interactions in tumorigenesis. Elife. 2: e00358. PMID 23682311 DOI: 10.7554/Elife.00358  0.795
2013 John SP, Chin CR, Perreira JM, Feeley EM, Aker AM, Savidis G, Smith SE, Elia AE, Everitt AR, Vora M, Pertel T, Elledge SJ, Kellam P, Brass AL. The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication. Journal of Virology. 87: 7837-52. PMID 23658454 DOI: 10.1128/Jvi.00481-13  0.316
2013 Larman HB, Salajegheh M, Nazareno R, Lam T, Sauld J, Steen H, Kong SW, Pinkus JL, Amato AA, Elledge SJ, Greenberg SA. Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis. Annals of Neurology. 73: 408-18. PMID 23596012 DOI: 10.1002/Ana.23840  0.652
2013 Zhu J, Larman HB, Gao G, Somwar R, Zhang Z, Laserson U, Ciccia A, Pavlova N, Church G, Zhang W, Kesari S, Elledge SJ. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). Nature Biotechnology. 31: 331-4. PMID 23503679 DOI: 10.1038/Nbt.2539  0.79
2013 Larman HB, Laserson U, Querol L, Verhaeghen K, Solimini NL, Xu GJ, Klarenbeek PL, Church GM, Hafler DA, Plenge RM, Nigrovic PA, De Jager PL, Weets I, Martens GA, O'Connor KC, ... Elledge SJ, et al. PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis. Journal of Autoimmunity. 43: 1-9. PMID 23497938 DOI: 10.1016/J.Jaut.2013.01.013  0.679
2013 Liu Q, Xu C, Kirubakaran S, Zhang X, Hur W, Liu Y, Kwiatkowski NP, Wang J, Westover KD, Gao P, Ercan D, Niepel M, Thoreen CC, Kang SA, Patricelli MP, ... ... Elledge SJ, et al. Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR. Cancer Research. 73: 2574-86. PMID 23436801 DOI: 10.1158/0008-5472.Can-12-1702  0.584
2013 Solimini NL, Liang AC, Xu C, Pavlova NN, Xu Q, Davoli T, Li MZ, Wong KK, Elledge SJ. STOP gene Phactr4 is a tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America. 110: E407-14. PMID 23319639 DOI: 10.1073/Pnas.1221385110  0.75
2013 Wang CI, Alekseyenko AA, LeRoy G, Elia AE, Gorchakov AA, Britton LM, Elledge SJ, Kharchenko PV, Garcia BA, Kuroda MI. Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila. Nature Structural & Molecular Biology. 20: 202-9. PMID 23295261 DOI: 10.1038/Nsmb.2477  0.331
2013 Pavlova NN, Pallasch C, Elia AE, Braun CJ, Westbrook TF, Hemann M, Elledge SJ. Author response: A role for PVRL4-driven cell–cell interactions in tumorigenesis Elife. DOI: 10.7554/Elife.00358.038  0.763
2013 Davoli T, Solimini NL, Pavlova NN, Xu Q, Mengwasser K, Sack LM, Liang AC, Schlabach MR, Luo J, Burrows AE, Anselmo AN, Li MZ, Elledge SJ. Abstract IA28: Haploinsufficiency in cancer Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-Ia28  0.797
2013 Solimini N, Pavlova NN, Mermel C, Xu Q, Burrows AE, Luo J, li M, Beroukhim R, Meyerson M, Elledge SJ. Abstract SY25-03: Haploinsufficiency in cancer: When half simply isn't good enough. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Sy25-03  0.756
2013 Li J, Zhu S, Kozono D, Futulan D, Gonda D, Kushwaha D, Kahle K, Elledge S, Chen CC. Abstract 4366: ShRNA-based cellular proliferation signaling analysis revealed DRD2 as a novel therapeutic target for glioblastoma. Cancer Research. 73: 4366-4366. DOI: 10.1158/1538-7445.Am2013-4366  0.572
2012 Larman HB, Xu GJ, Pavlova NN, Elledge SJ. Construction of a rationally designed antibody platform for sequencing-assisted selection Proceedings of the National Academy of Sciences of the United States of America. 109: 18523-18528. PMID 23064642 DOI: 10.1073/Pnas.1215549109  0.772
2012 Tan X, Hu L, Luquette LJ, Gao G, Liu Y, Qu H, Xi R, Lu ZJ, Park PJ, Elledge SJ. Systematic identification of synergistic drug pairs targeting HIV. Nature Biotechnology. 30: 1125-30. PMID 23064238 DOI: 10.1038/nbt.2391  0.429
2012 Zhu J, Gaiha GD, John SP, Pertel T, Chin CR, Gao G, Qu H, Walker BD, Elledge SJ, Brass AL. Reactivation of latent HIV-1 by inhibition of BRD4. Cell Reports. 2: 807-16. PMID 23041316 DOI: 10.1016/J.Celrep.2012.09.008  0.381
2012 Ciccia A, Nimonkar AV, Hu Y, Hajdu I, Achar YJ, Izhar L, Petit SA, Adamson B, Yoon JC, Kowalczykowski SC, Livingston DM, Haracska L, Elledge SJ. Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. Molecular Cell. 47: 396-409. PMID 22704558 DOI: 10.1016/J.Molcel.2012.05.024  0.777
2012 Solimini NL, Xu Q, Mermel CH, Liang AC, Schlabach MR, Luo J, Burrows AE, Anselmo AN, Bredemeyer AL, Li MZ, Beroukhim R, Meyerson M, Elledge SJ. Recurrent hemizygous deletions in cancers may optimize proliferative potential. Science (New York, N.Y.). 337: 104-9. PMID 22628553 DOI: 10.1126/Science.1219580  0.787
2012 Elia AEH, Elledge SJ. BRCA1 as tumor suppressor: Lord without its RING? Breast Cancer Research. 14. PMID 22494569 DOI: 10.1186/Bcr3118  0.349
2012 Aceto N, Sausgruber N, Brinkhaus H, Gaidatzis D, Martiny-Baron G, Mazzarol G, Confalonieri S, Quarto M, Hu G, Balwierz PJ, Pachkov M, Elledge SJ, Van Nimwegen E, Stadler MB, Bentires-Alj M. Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop Nature Medicine. 18: 529-537. PMID 22388088 DOI: 10.1038/Nm.2645  0.556
2012 Adamson B, Smogorzewska A, Sigoillot FD, King RW, Elledge SJ. A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Nature Cell Biology. 14: 318-28. PMID 22344029 DOI: 10.1038/Ncb2426  0.702
2012 Li MZ, Elledge SJ. SLIC: A method for sequence- and ligation-independent cloning Methods in Molecular Biology. 852: 51-59. PMID 22328425 DOI: 10.1007/978-1-61779-564-0_5  0.335
2012 Tan X, Lu ZJ, Gao G, Xu Q, Hu L, Fellmann C, Li MZ, Qu H, Lowe SW, Hannon GJ, Elledge SJ. Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy Proceedings of the National Academy of Sciences of the United States of America. 109: 869-874. PMID 22219365 DOI: 10.1073/Pnas.1119873109  0.463
2012 Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, ... ... Elledge SJ, et al. A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science (New York, N.Y.). 335: 348-53. PMID 22157079 DOI: 10.1126/Science.1212728  0.746
2012 Solimini NL, Bredemeyer AL, Li MZ, Beroukhim R, Meyerson M, Elledge SJ, Pavlova NN, Xu Q, Mermel CH, Liang AC, Schlabach MR, Luo J, Burrows AE, Anselmo AN. Abstract IA8: Genetic approaches to cancer Cancer Research. 72. DOI: 10.1158/1538-7445.Csb12-Ia8  0.734
2012 Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, ... ... Elledge SJ, et al. Abstract 3091: A sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis Cancer Research. 72: 3091-3091. DOI: 10.1158/1538-7445.Am2012-3091  0.746
2012 Emanuele MJ, Elia AEH, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PWC, Yen HCS, Elledge SJ. Erratum: Global identification of modular cullin-ring ligase substrates (Cell (2011) 147 (459-475)) Cell. 148: 620-622. DOI: 10.1016/J.Cell.2012.01.028  0.767
2011 Emanuele MJ, Elia AEH, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PWC, Yen HCS, Elledge SJ. Global identification of modular cullin-RING ligase substrates Cell. 147: 459-474. PMID 21963094 DOI: 10.1016/J.Cell.2011.09.019  0.803
2011 Hajdu I, Ciccia A, Lewis SM, Elledge SJ. Wolf - Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage Proceedings of the National Academy of Sciences of the United States of America. 108: 13130-13134. PMID 21788515 DOI: 10.1073/Pnas.1110081108  0.4
2011 Joo W, Xu G, Persky NS, Smogorzewska A, Rudge DG, Buzovetsky O, Elledge SJ, Pavletich NP. Structure of the FANCI-FANCD2 complex: Insights into the Fanconi anemia DNA repair pathway Science. 333: 312-316. PMID 21764741 DOI: 10.1126/Science.1205805  0.68
2011 Cotta-Ramusino C, McDonald ER, Hurov K, Sowa ME, Harper JW, Elledge SJ. A DNA damage response screen identifies RHINO, a 9-1-1 and topBP1 interacting protein required for ATR signaling Science. 332: 1313-1317. PMID 21659603 DOI: 10.1126/Science.1203430  0.465
2011 Emanuele MJ, Ciccia A, Elia AEH, Elledge SJ. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate Proceedings of the National Academy of Sciences of the United States of America. 108: 9845-9850. PMID 21628590 DOI: 10.1073/Pnas.1106136108  0.736
2011 Larman HB, Zhao Z, Laserson U, Li MZ, Ciccia A, Gakidis MA, Church GM, Kesari S, Leproust EM, Solimini NL, Elledge SJ. Autoantigen discovery with a synthetic human peptidome. Nature Biotechnology. 29: 535-41. PMID 21602805 DOI: 10.1038/Nbt.1856  0.693
2011 Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, ... ... Elledge SJ, et al. Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell. 144: 703-18. PMID 21376233 DOI: 10.1016/J.Cell.2011.02.003  0.794
2011 Fellmann C, Zuber J, McJunkin K, Chang K, Malone CD, Dickins RA, Xu Q, Hengartner MO, Elledge SJ, Hannon GJ, Lowe SW. Functional identification of optimized RNAi triggers using a massively parallel sensor assay. Molecular Cell. 41: 733-46. PMID 21353615 DOI: 10.1016/J.Molcel.2011.02.008  0.309
2011 Meerbrey KL, Hu G, Kessler JD, Roarty K, Li MZ, Fang JE, Herschkowitz JI, Burrows AE, Ciccia A, Sun T, Schmitt EM, Bernardi RJ, Fu X, Bland CS, Cooper TA, ... ... Elledge SJ, et al. The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 108: 3665-70. PMID 21307310 DOI: 10.1073/Pnas.1019736108  0.789
2011 Huang IC, Bailey CC, Weyer JL, Radoshitzky SR, Becker MM, Chiang JJ, Brass AL, Ahmed AA, Chi X, Dong L, Longobardi LE, Boltz D, Kuhn JH, Elledge SJ, Bavari S, et al. Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. Plos Pathogens. 7: e1001258. PMID 21253575 DOI: 10.1371/Journal.Ppat.1001258  0.31
2011 Pavlova NN, Elledge SJ. Abstract PR2: A genetic screen for novel determinants of anoikis resistance identifies PVRL4 Cancer Research. 71. DOI: 10.1158/1538-7445.Fbcr11-Pr2  0.35
2011 Burrows AE, Smogorzewska A, Elledge SJ. Abstract A33: A whole genome RNAi screen identifies BRD7 and BAF180 as p53 regulators required for senescence Cancer Research. 71. DOI: 10.1158/1538-7445.Fbcr11-A33  0.771
2011 Liu Q, Zhou D, Shiotani B, Gray NS, Elledge SJ, Zou L. Abstract 1358: Discovery and optimization of potent and selective benzonaphthyridinone analogs as dual mTOR/ATR small molecular inhibitors for treatment of cancer Cancer Research. 71: 1358-1358. DOI: 10.1158/1538-7445.Am2011-1358  0.656
2010 O'Connell BC, Adamson B, Lydeard JR, Sowa ME, Ciccia A, Bredemeyer AL, Schlabach M, Gygi SP, Elledge SJ, Harper J. Wade JW. A Genome-wide Camptothecin Sensitivity Screen Identifies a Mammalian MMS22L-NFKBIL2 Complex Required for Genomic Stability Molecular Cell. 40: 645-657. PMID 21055985 DOI: 10.1016/J.Molcel.2010.10.022  0.746
2010 Ciccia A, Elledge SJ. The DNA Damage Response: Making It Safe to Play with Knives Molecular Cell. 40: 179-204. PMID 20965415 DOI: 10.1016/J.Molcel.2010.09.019  0.405
2010 Chou DM, Adamson B, Dephoure NE, Tan X, Nottke AC, Hurov KE, Gygi SP, Colaiácovo MP, Elledge SJ. A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage Proceedings of the National Academy of Sciences of the United States of America. 107: 18475-18480. PMID 20937877 DOI: 10.1073/Pnas.1012946107  0.558
2010 Hurov KE, Cotta-Ramusino C, Elledge SJ. A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability Genes and Development. 24: 1939-1950. PMID 20810650 DOI: 10.1101/Gad.1934210  0.456
2010 Burrows AE, Smogorzewska A, Elledge SJ. Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence Proceedings of the National Academy of Sciences of the United States of America. 107: 14280-14285. PMID 20660729 DOI: 10.1073/Pnas.1009559107  0.817
2010 Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJ. Wnt signaling regulates mitochondrial physiology and insulin sensitivity Genes and Development. 24: 1507-1518. PMID 20634317 DOI: 10.1101/Gad.1924910  0.313
2010 Smogorzewska A, Desetty R, Saito TT, Schlabach M, Lach FP, Sowa ME, Clark AB, Kunkel TA, Harper JW, Colaiácovo MP, Elledge SJ. A Genetic Screen Identifies FAN1, a Fanconi Anemia-Associated Nuclease Necessary for DNA Interstrand Crosslink Repair Molecular Cell. 39: 36-47. PMID 20603073 DOI: 10.1016/J.Molcel.2010.06.023  0.677
2010 Song EJ, Werner SL, Neubauer J, Stegmeier F, Aspden J, Rio D, Harper JW, Elledge SJ, Kirschner MW, Rape M. The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. Genes & Development. 24: 1434-47. PMID 20595234 DOI: 10.1101/Gad.1925010  0.304
2010 Swedlow JR, Cotta-Ramusino C, Elledge SJ. Cell biology forum: Genome-wide view of mitosis Nature. 464: 684-685. PMID 20360724 DOI: 10.1038/464684A  0.303
2010 Schlabach MR, Hu JK, Li M, Elledge SJ. Synthetic design of strong promoters Proceedings of the National Academy of Sciences of the United States of America. 107: 2538-2543. PMID 20133776 DOI: 10.1073/Pnas.0914803107  0.33
2010 Sun T, Meerbrey K, Kessler J, Botero M, Migliaccio I, Nguyen D, Pavlova N, Bernardi R, Schmitt E, Hilsenbeck S, Creighton C, Shaw C, Gibbs R, Wheeler D, Osborne C, ... ... Elledge S, et al. Abstract S6-10: Identification of a Novel Tumor Suppressor Network Reveals a Role for Proto-Oncogenic Receptor Tyrosine Kinases in Triple-Negative Breast Cancer Cancer Research. 70. DOI: 10.1158/0008-5472.Sabcs10-S6-10  0.742
2009 Knipscheer P, Räschle M, Smogorzewska A, Enoiu M, Ho TV, Schärer OD, Elledge SJ, Walter JC. The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science (New York, N.Y.). 326: 1698-701. PMID 19965384 DOI: 10.1126/Science.1182372  0.69
2009 Ciccia A, Bredemeyer AL, Sowa ME, Terret ME, Jallepalli PV, Harper JW, Elledge SJ. The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart Genes and Development. 23: 2415-2425. PMID 19793862 DOI: 10.1101/Gad.1832309  0.742
2009 Shen X, Do H, Li Y, Chung WH, Tomasz M, de Winter JP, Xia B, Elledge SJ, Wang W, Li L. Recruitment of Fanconi Anemia and Breast Cancer Proteins to DNA Damage Sites Is Differentially Governed by Replication Molecular Cell. 35: 716-723. PMID 19748364 DOI: 10.1016/J.Molcel.2009.06.034  0.435
2009 Svendsen JM, Smogorzewska A, Sowa ME, O'Connell BC, Gygi SP, Elledge SJ, Harper JW. Mammalian BTBD12/SLX4 Assembles A Holliday Junction Resolvase and Is Required for DNA Repair Cell. 138: 63-77. PMID 19596235 DOI: 10.1016/J.Cell.2009.06.030  0.688
2009 Naylor ML, Li JM, Osborn AJ, Elledge SJ. Mrc1 phosphorylation in response to DNA replication stress is required for Mec1 accumulation at the stalled fork. Proceedings of the National Academy of Sciences of the United States of America. 106: 12765-70. PMID 19515819 DOI: 10.1073/Pnas.0904623106  0.396
2009 Luo J, Emanuele MJ, Li D, Creighton CJ, Schlabach MR, Westbrook TF, Wong KK, Elledge SJ. A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene Cell. 137: 835-848. PMID 19490893 DOI: 10.1016/J.Cell.2009.05.006  0.784
2009 Hu G, Kim J, Xu Q, Leng Y, Orkin SH, Elledge SJ. A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal Genes and Development. 23: 837-848. PMID 19339689 DOI: 10.1101/Gad.1769609  0.574
2009 Luo J, Solimini NL, Elledge SJ. Principles of cancer therapy: oncogene and non-oncogene addiction. Cell. 136: 823-37. PMID 19269363 DOI: 10.1016/J.Cell.2009.02.024  0.301
2009 Wang B, Hurov K, Hofmann K, Elledge SJ. NBA1, a new player in the Brcal A complex, is required for DNA damage resistance and checkpoint control Genes and Development. 23: 729-739. PMID 19261749 DOI: 10.1101/Gad.1770309  0.408
2009 Xiao A, Li H, Shechter D, Ahn SH, Fabrizio LA, Erdjument-Bromage H, Ishibe-Murakami S, Wang B, Tempst P, Hofmann K, Patel DJ, Elledge SJ, Allis CD. WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature. 457: 57-62. PMID 19092802 DOI: 10.1038/Nature07668  0.414
2008 Mulligan P, Westbrook TF, Ottinger M, Pavlova N, Chang B, Macia E, Shi YJ, Barretina J, Liu J, Howley PM, Elledge SJ, Shi Y. CDYL Bridges REST and Histone Methyltransferases for Gene Repression and Suppression of Cellular Transformation Molecular Cell. 32: 718-726. PMID 19061646 DOI: 10.1016/J.Molcel.2008.10.025  0.786
2008 Collis SJ, Ciccia A, Deans AJ, Ho?ejší Z, Martin JS, Maslen SL, Skehel JM, Elledge SJ, West SC, Boulton SJ. FANCM and FAAP24 Function in ATR-Mediated Checkpoint Signaling Independently of the Fanconi Anemia Core Complex Molecular Cell. 32: 313-324. PMID 18995830 DOI: 10.1016/J.Molcel.2008.10.014  0.433
2008 Yen HCS, Elledge SJ. Identification of SCF ubiquitin ligase substrates by global protein stability profiling Science. 322: 923-929. PMID 18988848 DOI: 10.1126/Science.1160462  0.363
2008 Yen HCS, Xu Q, Chou DM, Zhao Z, Elledge SJ. Global protein stability profiling in mammalian cells Science. 322: 918-923. PMID 18988847 DOI: 10.1126/Science.1160489  0.304
2008 Li JM, Tetzlaff MT, Elledge SJ. Identification of MSA1, a cell cycle-regulated, dosage suppressor of drc1/sld2 and dpb11 mutants Cell Cycle. 7: 3388-3398. PMID 18948746 DOI: 10.4161/Cc.7.21.6932  0.43
2008 Ishiai M, Kitao H, Smogorzewska A, Tomida J, Kinomura A, Uchida E, Saberi A, Kinoshita E, Kinoshita-Kikuta E, Koike T, Tashiro S, Elledge SJ, Takata M. FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway Nature Structural and Molecular Biology. 15: 1138-1146. PMID 18931676 DOI: 10.1038/Nsmb.1504  0.688
2008 Lee YD, Wang J, Stubbe J, Elledge SJ. Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase. Molecular Cell. 32: 70-80. PMID 18851834 DOI: 10.1016/J.Molcel.2008.08.018  0.428
2008 Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, Sultana H, Brass AL, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason PW, Koski RA, Elledge SJ, et al. RNA interference screen for human genes associated with West Nile virus infection. Nature. 455: 242-5. PMID 18690214 DOI: 10.1038/Nature07207  0.33
2008 Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP. A quantitative atlas of mitotic phosphorylation Proceedings of the National Academy of Sciences of the United States of America. 105: 10762-10767. PMID 18669648 DOI: 10.1073/Pnas.0805139105  0.378
2008 Luo J, Elledge SJ. Cancer: Deconstructing oncogenesis Nature. 453: 995-996. PMID 18563141 DOI: 10.1038/453995A  0.343
2008 Burrows AE, Elledge SJ. How ATR turns on: TopBP1 goes on ATRIP with ATR Genes and Development. 22: 1416-1421. PMID 18519633 DOI: 10.1101/Gad.1685108  0.805
2008 Westbrook TF, Hu G, Ang XL, Mulligan P, Pavlova NN, Liang A, Leng Y, Maehr R, Shi Y, Harper JW, Elledge SJ. SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation Nature. 452: 370-374. PMID 18354483 DOI: 10.1038/Nature06780  0.775
2008 Schlabach MR, Luo J, Solimini NL, Hu G, Xu Q, Li MZ, Zhao Z, Smogorzewska A, Sowa ME, Ang XL, Westbrook TF, Liang AC, Chang K, Hackett JA, Harper JW, ... ... Elledge SJ, et al. Cancer proliferation gene discovery through functional genomics Science. 319: 620-624. PMID 18239126 DOI: 10.1126/Science.1149200  0.802
2008 Schlabach MR, Luo J, Solimini NL, Hu G, Xu Q, Li MZ, Zhao Z, Smogorzewska A, Sowa ME, Ang XL, Westbrook TF, Liang AC, Chang K, Hackett JA, Harper JW, ... ... Elledge SJ, et al. Cancer proliferation gene discovery through functional genomics Science. 319: 620-624. PMID 18239126 DOI: 10.1126/Science.1149200  0.802
2008 Silva JM, Marran K, Parker JS, Silva J, Golding M, Schlabach MR, Elledge SJ, Hannon GJ, Chang K. Profiling essential genes in human mammary cells by multiplex RNAi screening Science. 319: 617-620. PMID 18239125 DOI: 10.1126/Science.1149185  0.376
2008 Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ, Lieberman J, Elledge SJ. Identification of host proteins required for HIV infection through a functional genomic screen. Science (New York, N.Y.). 319: 921-6. PMID 18187620 DOI: 10.1126/Science.1152725  0.332
2007 Harper JW, Elledge SJ. The DNA Damage Response: Ten Years After Molecular Cell. 28: 739-745. PMID 18082599 DOI: 10.1016/J.Molcel.2007.11.015  0.4
2007 Wang B, Elledge SJ. Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage Proceedings of the National Academy of Sciences of the United States of America. 104: 20759-20763. PMID 18077395 DOI: 10.1073/Pnas.0710061104  0.401
2007 Stewart GS, Stankovic T, Byrd PJ, Wechsler T, Miller ES, Huissoon A, Drayson MT, West SC, Elledge SJ, Taylor AM. RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling. Proceedings of the National Academy of Sciences of the United States of America. 104: 16910-5. PMID 17940005 DOI: 10.1073/Pnas.0708408104  0.312
2007 Stewart GS, Stankovic T, Byrd PJ, Wechsler T, Miller ES, Huissoon A, Drayson MT, West SC, Elledge SJ, Taylor AM. RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling. Proceedings of the National Academy of Sciences of the United States of America. 104: 16910-5. PMID 17940005 DOI: 10.1073/Pnas.0708408104  0.312
2007 Popov N, Wanzel M, Madiredjo M, Zhang D, Beijersbergen R, Bernards R, Moll R, Elledge SJ, Eilers M. The ubiquitin-specific protease USP28 is required for MYC stability. Nature Cell Biology. 9: 765-74. PMID 17558397 DOI: 10.1038/Ncb1601  0.35
2007 Popov N, Wanzel M, Madiredjo M, Zhang D, Beijersbergen R, Bernards R, Moll R, Elledge SJ, Eilers M. The ubiquitin-specific protease USP28 is required for MYC stability. Nature Cell Biology. 9: 765-74. PMID 17558397 DOI: 10.1038/Ncb1601  0.35
2007 Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi SP, Elledge SJ. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response Science. 316: 1194-1198. PMID 17525340 DOI: 10.1126/Science.1139476  0.716
2007 Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage Science. 316: 1160-1166. PMID 17525332 DOI: 10.1126/Science.1140321  0.695
2007 Stegmeier F, Sowa ME, Nalepa G, Gygi SP, Harper JW, Elledge SJ. The tumor suppressor CYLD regulates entry into mitosis Proceedings of the National Academy of Sciences of the United States of America. 104: 8869-8874. PMID 17495026 DOI: 10.1073/Pnas.0703268104  0.388
2007 Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature. 446: 876-81. PMID 17443180 DOI: 10.1038/Nature05694  0.366
2007 Draviam VM, Stegmeier F, Nalepa G, Sowa ME, Chen J, Liang A, Hannon GJ, Sorger PK, Harper JW, Elledge SJ. A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. Nature Cell Biology. 9: 556-64. PMID 17417629 DOI: 10.1038/Ncb1569  0.37
2007 Smogorzewska A, Matsuoka S, Vinciguerra P, McDonald ER, Hurov KE, Luo J, Ballif BA, Gygi SP, Hofmann K, D'Andrea AD, Elledge SJ. Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell. 129: 289-301. PMID 17412408 DOI: 10.1016/J.Cell.2007.03.009  0.706
2007 Zaugg K, Su YW, Reilly PT, Moolani Y, Cheung CC, Hakem R, Hirao A, Liu Q, Elledge SJ, Mak TW. Cross-talk between Chk1 and Chk2 in double-mutant thymocytes. Proceedings of the National Academy of Sciences of the United States of America. 104: 3805-10. PMID 17360434 DOI: 10.1073/Pnas.0611584104  0.355
2007 Li MZ, Elledge SJ. Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC Nature Methods. 4: 251-256. PMID 17293868 DOI: 10.1038/Nmeth1010  0.354
2007 Li MZ, Elledge SJ. SLIC sub-cloning using T4 DNA polymerase treated inserts without RecA Nature Protocols. DOI: 10.1038/Nprot.2007.121  0.309
2006 Chou DM, Elledge SJ. Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function Proceedings of the National Academy of Sciences of the United States of America. 103: 18143-18147. PMID 17116885 DOI: 10.1073/Pnas.0609251103  0.433
2006 Chang K, Elledge SJ, Hannon GJ. Lessons from Nature: microRNA-based shRNA libraries Nature Methods. 3: 707-714. PMID 16929316 DOI: 10.1038/Nmeth923  0.309
2006 Zhang D, Zaugg K, Mak TW, Elledge SJ. A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response Cell. 126: 529-542. PMID 16901786 DOI: 10.1016/J.Cell.2006.06.039  0.505
2006 Wang X, Zou L, Lu T, Bao S, Hurov KE, Hittelman WN, Elledge SJ, Li L. Rad17 Phosphorylation Is Required for Claspin Recruitment and Chk1 Activation in Response to Replication Stress Molecular Cell. 23: 331-341. PMID 16885023 DOI: 10.1016/J.Molcel.2006.06.022  0.632
2006 Cao L, Kim S, Xiao C, Wang RH, Coumoul X, Wang X, Li WM, Xu XL, De Soto JA, Takai H, Mai S, Elledge SJ, Motoyama N, Deng CX. ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency. The Embo Journal. 25: 2167-77. PMID 16675955 DOI: 10.1038/Sj.Emboj.7601115  0.323
2006 Lee YD, Elledge SJ. Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1 Genes and Development. 20: 334-344. PMID 16452505 DOI: 10.1101/Gad.1380506  0.385
2005 Westbrook TF, Stegmeier F, Elledge SJ. Dissecting cancer pathways and vulnerabilities with RNAi Cold Spring Harbor Symposia On Quantitative Biology. 70: 435-444. PMID 16869781 DOI: 10.1101/Sqb.2005.70.031  0.673
2005 Turnell AS, Stewart GS, Grand RJA, Rookes SM, Martin A, Yamano H, Elledge SJ, Gallimore PH. The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression Nature. 438: 690-695. PMID 16319895 DOI: 10.1038/Nature04151  0.355
2005 Adams MM, Wang B, Xia Z, Morales JC, Lu X, Donehower LA, Bochar DA, Elledge SJ, Carpenter PB. 53BP1 oligomerization is independent of its methylation by PRMT1. Cell Cycle (Georgetown, Tex.). 4: 1854-61. PMID 16294047 DOI: 10.4161/Cc.4.12.2282  0.38
2005 Lin SY, Rai R, Li K, Xu ZX, Elledge SJ. BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly Proceedings of the National Academy of Sciences of the United States of America. 102: 15105-15109. PMID 16217032 DOI: 10.1073/Pnas.0507722102  0.427
2005 Silva JM, Li MZ, Chang K, Ge W, Golding MC, Rickles RJ, Siolas D, Hu G, Paddison PJ, Schlabach MR, Sheth N, Bradshaw J, Burchard J, Kulkarni A, Cavet G, ... ... Elledge SJ, et al. Second-generation shRNA libraries covering the mouse and human genomes. Nature Genetics. 37: 1281-8. PMID 16200065 DOI: 10.1038/Ng1650  0.522
2005 Perry KL, Elledge SJ, Mitchell BB, Marsh L, Walker GC. umuDC and mucAB operons whose products are required for UV light- and chemical-induced mutagenesis: UmuD, MucA, and LexA proteins share homology. 1985. Dna Repair. 4: 1054-8. PMID 16196126  0.402
2005 Stegmeier F, Hu G, Rickles RJ, Hannon GJ, Elledge SJ. A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 13212-7. PMID 16141338 DOI: 10.1073/Pnas.0506306102  0.549
2005 Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ, Depinho RA, Chin L, Elledge SJ. A genetic screen for candidate tumor suppressors identifies REST. Cell. 121: 837-48. PMID 15960972 DOI: 10.1016/J.Cell.2005.03.033  0.691
2005 Altman S, Bassler BL, Beckwith J, Belfort M, Berg HC, Bloom B, Brenchley JE, Campbell A, Collier RJ, Connell N, Cozzarelli NR, Craig NL, Darst S, Ebright RH, Elledge SJ, et al. An open letter to Elias Zerhouni. Science (New York, N.Y.). 307: 1409-10. PMID 15746409 DOI: 10.1126/Science.307.5714.1409C  0.621
2005 Li MZ, Elledge SJ. MAGIC, an in vivo genetic method for the rapid construction of recombinant DNA molecules Nature Genetics. 37: 311-319. PMID 15731760 DOI: 10.1038/Ng1505  0.365
2005 Li JM, Li Y, Elledge SJ. Genetic analysis of the kinetochore DASH complex reveals an antagonistic relationship with the Ras/protein kinase A pathway and a novel subunit required for Ask1 association Molecular and Cellular Biology. 25: 767-778. PMID 15632076 DOI: 10.1128/Mcb.25.2.767-778.2005  0.361
2004 Ye X, Nalepa G, Welcker M, Kessler BM, Spooner E, Qin J, Elledge SJ, Clurman BE, Harper JW. Recognition of phosphodegron motifs in human cyclin E by the SCF Fbw7 ubiquitin ligase Journal of Biological Chemistry. 279: 50110-50119. PMID 15364936 DOI: 10.1074/Jbc.M409226200  0.319
2004 Lam MH, Liu Q, Elledge SJ, Rosen JM. Chk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell. 6: 45-59. PMID 15261141 DOI: 10.1016/J.Ccr.2004.06.015  0.389
2004 Cortez D, Glick G, Elledge SJ. Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases Proceedings of the National Academy of Sciences of the United States of America. 101: 10078-10083. PMID 15210935 DOI: 10.1073/Pnas.0403410101  0.67
2004 Lin SY, Li K, Stewart GS, Elledge SJ. Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation Proceedings of the National Academy of Sciences of the United States of America. 101: 6484-6489. PMID 15096610 DOI: 10.1073/Pnas.0401847101  0.451
2004 Paddison PJ, Silva JM, Conklin DS, Schlabach M, Li M, Aruleba S, Balija V, O'Shaughnessy A, Gnoj L, Scobie K, Chang K, Westbrook T, Cleary M, Sachidanandam R, McCombie WR, ... Elledge SJ, et al. A resource for large-scale RNA-interference-based screens in mammals. Nature. 428: 427-31. PMID 15042091 DOI: 10.1038/Nature02370  0.659
2004 Tetzlaff MT, Yu W, Li M, Zhang P, Finegold M, Mahon K, Harper JW, Schwartz RJ, Elledge SJ. Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein Proceedings of the National Academy of Sciences of the United States of America. 101: 3338-3345. PMID 14766969 DOI: 10.1073/Pnas.0307875101  0.359
2003 Jin J, Shirogane T, Xu L, Nalepa G, Qin J, Elledge SJ, Harper JW. SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes & Development. 17: 3062-74. PMID 14681206 DOI: 10.1101/Gad.1157503  0.454
2003 Zou L, Liu D, Elledge SJ. Replication protein A-mediated recruitment and activation of Rad17 complexes Proceedings of the National Academy of Sciences of the United States of America. 100: 13827-13832. PMID 14605214 DOI: 10.1073/Pnas.2336100100  0.646
2003 Xu L, Wei Y, Reboul J, Vaglio P, Shin TH, Vidal M, Elledge SJ, Harper JW. BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature. 425: 316-21. PMID 13679922 DOI: 10.1038/Nature01985  0.328
2003 Osborn AJ, Elledge SJ. Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53 Genes and Development. 17: 1755-1767. PMID 12865299 DOI: 10.1101/Gad.1098303  0.422
2003 Lin SY, Elledge SJ. Multiple tumor suppressor pathways negatively regulate telomerase Cell. 113: 881-889. PMID 12837246 DOI: 10.1016/S0092-8674(03)00430-6  0.355
2003 Zou L, Elledge SJ. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes Science. 300: 1542-1548. PMID 12791985 DOI: 10.1126/Science.1083430  0.663
2003 Li Y, Elledge SJ. The DASH complex component Ask1 is a cell cycle-regulated Cdk substrate in Saccharomyces cerevisiae Cell Cycle (Georgetown, Tex.). 2: 143-148. PMID 12695666 DOI: 10.4161/Cc.2.2.336  0.375
2003 Wang X, Zou L, Zheng H, Wei Q, Elledge SJ, Li L. Genomic instability and endoreduplication triggered by RAD17 deletion Genes and Development. 17: 965-970. PMID 12672690 DOI: 10.1101/Gad.1065103  0.631
2003 Wang Y, Shirogane T, Liu D, Harper JW, Elledge SJ. Exit from exit: Resetting the cell cycle through Amn1 inhibition of G protein signaling Cell. 112: 697-709. PMID 12628189 DOI: 10.1016/S0092-8674(03)00121-1  0.596
2003 Stewart GS, Wang B, Bigneli CR, Taylor AMR, Elledge SJ. MDC1 is a mediator of the mammalian DNA damage checkpoint Nature. 421: 961-966. PMID 12607005 DOI: 10.1038/Nature01446  0.449
2003 Morales JC, Xia Z, Lu T, Aldrich MB, Wang B, Rosales C, Kellems RE, Hittelman WN, Elledge SJ, Carpenter PB. Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability. The Journal of Biological Chemistry. 278: 14971-7. PMID 12578828 DOI: 10.1074/Jbc.M212484200  0.435
2002 Hu F, Elledge SJ. Bub2 is a cell cycle regulated phospho-protein controlled by multiple checkpoints Cell Cycle (Georgetown, Tex.). 1: 351-355. PMID 12461298 DOI: 10.4161/Cc.1.5.154  0.405
2002 Osborn AJ, Elledge SJ, Zou L. Checking on the fork: The DNA-replication stress-response pathway Trends in Cell Biology. 12: 509-516. PMID 12446112 DOI: 10.1016/S0962-8924(02)02380-2  0.643
2002 Wang B, Matsuoka S, Carpenter PB, Elledge SJ. 53BP1, a mediator of the DNA damage checkpoint Science. 298: 1435-1438. PMID 12364621 DOI: 10.1126/Science.1076182  0.432
2002 Wilson JH, Elledge SJ. Cancer: BRCA2 enters the fray Science. 297: 1822-1823. PMID 12228708 DOI: 10.1126/Science.1077171  0.373
2002 Hirao A, Cheung A, Duncan G, Girard PM, Elia AJ, Wakeham A, Okada H, Sarkissian T, Wong JA, Sakai T, De Stanchina E, Bristow RG, Suda T, Lowe SW, Jeggo PA, ... Elledge SJ, et al. Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Molecular and Cellular Biology. 22: 6521-32. PMID 12192050 DOI: 10.1128/Mcb.22.18.6521-6532.2002  0.359
2002 Stewart G, Elledge SJ. The two faces of BRCA2, a FANCtastic discovery Molecular Cell. 10: 2-4. PMID 12150898 DOI: 10.1016/S1097-2765(02)00580-4  0.354
2002 Elledge SJ, Amon A. The BRCA1 suppressor hypothesis: an explanation for the tissue-specific tumor development in BRCA1 patients. Cancer Cell. 1: 129-32. PMID 12086871 DOI: 10.1016/S1535-6108(02)00041-7  0.322
2002 Bachant J, Alcasabas A, Blat Y, Kleckner N, Elledge SJ. The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II. Molecular Cell. 9: 1169-82. PMID 12086615 DOI: 10.1016/S1097-2765(02)00543-9  0.757
2002 Wang H, Elledge SJ. Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway Genetics. 160: 1295-1304. PMID 11973288  0.326
2002 Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, Wang P, Chu C, Koepp DM, Elledge SJ, Pagano M, Conaway RC, Conaway JW, Harper JW, Pavletich NP. Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex Nature. 416: 703-709. PMID 11961546 DOI: 10.1038/416703A  0.781
2002 Zou L, Cortez D, Elledge SJ. Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin Genes and Development. 16: 198-208. PMID 11799063 DOI: 10.1101/Gad.950302  0.759
2002 Li Y, Bachant J, Alcasabas AA, Wang Y, Qin J, Elledge SJ. The mitotic spindle is required for loading of the DASH complex onto the kinetochore Genes and Development. 16: 183-197. PMID 11799062 DOI: 10.1101/Gad.959402  0.799
2002 Weiss RS, Matsuoka S, Elledge SJ, Leder P. Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway. Current Biology : Cb. 12: 73-7. PMID 11790307 DOI: 10.1016/S0960-9822(01)00626-1  0.443
2002 Zhang P, Li MZ, Elledge SJ. Towards genetic genome projects: Genomic library screening and gene-targeting vector construction in a single step Nature Genetics. 30: 31-39. PMID 11753384 DOI: 10.1038/Ng797  0.306
2001 Hu F, Wang Y, Liu D, Li Y, Qin J, Elledge SJ. Regulation of the Bub2/Bfa1 GAP complex by Cdc5 and cell cycle checkpoints Cell. 107: 655-665. PMID 11733064 DOI: 10.1016/S0092-8674(01)00580-3  0.632
2001 Cortez D, Guntuku S, Qin J, Elledge SJ. ATR and ATRIP: Partners in checkpoint signaling Science. 294: 1713-1716. PMID 11721054 DOI: 10.1126/Science.1065521  0.668
2001 Alcasabas AA, Osborn AJ, Bachant J, Hu F, Werler PJ, Bousset K, Furuya K, Diffley JF, Carr AM, Elledge SJ. Mrc1 transduces signals of DNA replication stress to activate Rad53. Nature Cell Biology. 3: 958-65. PMID 11715016 DOI: 10.1038/Ncb1101-958  0.77
2001 Gasch AP, Huang M, Metzner S, Botstein D, Elledge SJ, Brown PO. Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p. Molecular Biology of the Cell. 12: 2987-3003. PMID 11598186 DOI: 10.1091/Mbc.12.10.2987  0.702
2001 Koepp DM, Schaefer LK, Ye X, Keyomarsi K, Chu C, Harper JW, Elledge SJ. Phosphorylation-dependent ubiquitination of cyctin E by the SCFFbw7 ubiquitin ligase Science. 294: 173-177. PMID 11533444 DOI: 10.1126/Science.1065203  0.724
2001 Wang H, Liu D, Wang Y, Qin J, Elledge SJ. Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function Genes and Development. 15: 1361-1372. PMID 11390356 DOI: 10.1101/Gad.893201  0.632
2001 Paull TT, Cortez D, Bowers B, Elledge SJ, Gellert M. Direct DNA binding by Brca1 Proceedings of the National Academy of Sciences of the United States of America. 98: 6086-6091. PMID 11353843 DOI: 10.1073/Pnas.111125998  0.65
2001 Hu F, Alcasabas AA, Elledge SJ. Asf1 links Rad53 to control of chromatin assembly Genes and Development. 15: 1061-1066. PMID 11331602 DOI: 10.1101/Gad.873201  0.419
2001 Cho RJ, Huang M, Campbell MJ, Dong H, Steinmetz L, Sapinoso L, Hampton G, Elledge SJ, Davis RW, Lockhart DJ. Transcriptional regulation and function during the human cell cycle. Nature Genetics. 27: 48-54. PMID 11137997 DOI: 10.1038/83751  0.81
2000 Huang M, Elledge SJ. The FHA domain, a phosphoamino acid binding domain involved in the DNA damage response pathway Cold Spring Harbor Symposia On Quantitative Biology. 65: 413-421. PMID 12760057 DOI: 10.1101/Sqb.2000.65.413  0.644
2000 Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, Elledge SJ, Abraham RT. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress Genes and Development. 14: 2989-3002. PMID 11114888 DOI: 10.1101/Gad.851000  0.66
2000 Zhou BBS, Elledge SJ. The DNA damage response: Putting checkpoints in perspective Nature. 408: 433-439. PMID 11100718 DOI: 10.1038/35044005  0.408
2000 Schulman BA, Carrano AC, Jeffrey PD, Bowen Z, Kinnucan ERE, Finnin MS, Elledge SJ, Harper JW, Pagano M, Pavletich NP. Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex Nature. 408: 381-386. PMID 11099048 DOI: 10.1038/35042620  0.303
2000 Wang Y, Hu F, Elledge SJ. The Bfa1/Bub2 GAP complex comprises a universal checkpoint required to prevent mitotic exit Current Biology. 10: 1379-1382. PMID 11084339 DOI: 10.1016/S0960-9822(00)00779-X  0.619
2000 Liu Q, Li MZ, Liu D, Elledge SJ. Rapid construction of recombinant DNA by the univector plasmid-fusion system Methods in Enzymology. 328: 530-549. PMID 11075365 DOI: 10.1016/S0076-6879(00)28417-6  0.36
2000 Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro Proceedings of the National Academy of Sciences of the United States of America. 97: 10389-10394. PMID 10973490 DOI: 10.1073/Pnas.190030497  0.348
2000 Cortez D, Elledge SJ. Conducting the mitotic symphony Nature. 406: 354-356. PMID 10935617 DOI: 10.1038/35019227  0.562
2000 Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, Donehower LA, Elledge SJ. Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint Genes and Development. 14: 1448-1459. PMID 10859164 DOI: 10.1101/Gad.14.12.1448  0.655
2000 Gripp KW, Wotton D, Edwards MC, Roessler E, Ades L, Meinecke P, Richieri-Costa A, Zackai EH, Massagué J, Muenke M, Elledge SJ. Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination Nature Genetics. 25: 205-208. PMID 10835638 DOI: 10.1038/76074  0.324
2000 Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures Genes and Development. 14: 927-939. PMID 10783165 DOI: 10.1101/Gad.14.8.927  0.74
2000 Lozano G, Elledge SJ. p53 Sends nucleotides to repair DNA Nature. 404: 24-25. PMID 10716425 DOI: 10.1038/35003670  0.39
2000 Hirao A, Kong YY, Matsuoka S, Wakeham A, Ruland J, Yoshida H, Liu D, Elledge SJ, Mak TW. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science (New York, N.Y.). 287: 1824-7. PMID 10710310 DOI: 10.1126/Science.287.5459.1824  0.425
1999 Caspary T, Cleary MA, Perlman EJ, Zhang P, Elledge SJ, Tilghman SM. Oppositely imprinted genes p57(Kip2) and Igf2 interact in a mouse model for Beckwith-Wiedemann syndrome Genes and Development. 13: 3115-3124. PMID 10601037 DOI: 10.1101/Gad.13.23.3115  0.321
1999 Harper JW, Elledge SJ. Skipping into the E2F1-destruction pathway Nature Cell Biology. 1: E5-7. PMID 10559870 DOI: 10.1038/8952  0.329
1999 Sanchez Y, Bachant J, Wang H, Hu F, Liu D, Tetzlaff M, Elledge SJ. Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms Science. 286: 1166-1171. PMID 10550056 DOI: 10.1126/Science.286.5442.1166  0.822
1999 Cortez D, Wang Y, Qin J, Elledge SJ. Requirement of ATM-dependent phosphorylation of Brca1 in the DNA damage response to double-strand breaks Science. 286: 1162-1166. PMID 10550055 DOI: 10.1126/Science.286.5442.1162  0.739
1999 Winston JT, Koepp DM, Cihui Z, Elledge SJ, Harper JW. A family of mammalian F-box proteins Current Biology. 9: 1180-1182. PMID 10531037 DOI: 10.1016/S0960-9822(00)80021-4  0.721
1999 Ouspenski II, Elledge SJ, Brinkley BR. New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability Nucleic Acids Research. 27: 3001-3008. PMID 10454593 DOI: 10.1093/Nar/27.15.3001  0.358
1999 Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P. SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex Molecular Cell. 4: 21-33. PMID 10445024 DOI: 10.1016/S1097-2765(00)80184-7  0.59
1999 Koepp DM, Harper JW, Elledge SJ. How the cyclin became a cyclin: Regulated proteolysis in the cell cycle Cell. 97: 431-434. PMID 10338207 DOI: 10.1016/S0092-8674(00)80753-9  0.724
1999 Bachant JB, Elledge SJ. Mitotic treasures in the nucleolus Nature. 398: 757-758. PMID 10235256 DOI: 10.1038/19641  0.742
1999 Skowyra D, Koepp DM, Kamura T, Conrad MN, Conaway RC, Conaway JW, Elledge SJ, Harper JW. Reconstitution of G1 cyclin ubiquitination with complexes containing SCF(Grr1) and Rbx1 Science. 284: 662-665. PMID 10213692 DOI: 10.1126/Science.284.5414.662  0.777
1999 Kamura T, Koepp DM, Conrad MN, Skowyra D, Moreland RJ, Iliopoulos O, Lane WS, Kaelin WG, Elledge SJ, Conaway RC, Harper JW, Conaway JW. Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase Science. 284: 657-661. PMID 10213691 DOI: 10.1126/Science.284.5414.657  0.794
1999 Wang H, Elledge SJ. DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 96: 3824-3829. PMID 10097122 DOI: 10.1073/Pnas.96.7.3824  0.464
1999 Zhang P, Wong C, Liu D, Finegold M, Harper JW, Elledge SJ. p21CIP1 and p57KIP2 control muscle differentiation at the myogenin step Genes & Development. 13: 213-224. PMID 9925645 DOI: 10.1101/Gad.13.2.213  0.316
1999 Gómez Lahoz E, Liegeois NJ, Zhang P, Engelman JA, Horner J, Silverman A, Burde R, Roussel MF, Sherr CJ, Elledge SJ, DePinho RA. Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo. Molecular and Cellular Biology. 19: 353-63. PMID 9858559 DOI: 10.1128/Mcb.19.1.353  0.333
1998 Liu Q, Li MZ, Leibham D, Cortez D, Elledge SJ. The univector plasmid-fusion system, a method for rapid construction of recombinant DNA without restriction enzymes Current Biology. 8: 1300-1309. PMID 9843682 DOI: 10.1016/S0960-9822(07)00560-X  0.621
1998 Matsuoka S, Huang M, Elledge SJ. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science (New York, N.Y.). 282: 1893-7. PMID 9836640 DOI: 10.1126/Science.282.5395.1893  0.711
1998 Zhang P, Wong C, DePinho RA, Harper JW, Elledge SJ. Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development. Genes & Development. 12: 3162-7. PMID 9784491 DOI: 10.1101/Gad.12.20.3162  0.356
1998 Desany BA, Alcasabas AA, Bachant JB, Elledge SJ. Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway. Genes & Development. 12: 2956-70. PMID 9744871 DOI: 10.1101/Gad.12.18.2956  0.778
1998 Huang M, Zhou Z, Elledge SJ. The DNA Replication and Damage Checkpoint Pathways Induce Transcription by Inhibition of the Crt1 Repressor Cell. 94: 595-605. PMID 9741624 DOI: 10.1016/S0092-8674(00)81601-3  0.737
1998 Edwards MC, Wong C, Elledge SJ. Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity Molecular and Cellular Biology. 18: 4291-4300. PMID 9632813 DOI: 10.1128/Mcb.18.7.4291  0.349
1998 Elledge SJ, Harper JW. The role of protein stability in the cell cycle and cancer Biochimica Et Biophysica Acta. 1377. PMID 9606978 DOI: 10.1016/S0304-419X(98)00005-5  0.395
1998 Elledge SJ. Mitotic arrest: Mad2 prevents sleepy from waking up the APC. Science. 279: 999-1000. PMID 9490488 DOI: 10.1126/Science.279.5353.999  0.3
1998 Connell-Crowley L, Elledge SJ, Harper JW. G1 cyclin-dependent kinases are sufficient to initiate DNA synthesis in quiescent human fibroblasts Current Biology. 8: 65-68. PMID 9427630 DOI: 10.1016/S0960-9822(98)70021-1  0.352
1997 Skowyra D, Craig KL, Tyers M, Elledge SJ, Harper JW. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell. 91: 209-19. PMID 9346238 DOI: 10.1016/S0092-8674(00)80403-1  0.344
1997 Huang M, Elledge SJ. Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae. Molecular and Cellular Biology. 17: 6105-13. PMID 9315670 DOI: 10.1128/Mcb.17.10.6105  0.708
1997 Sanchez Y, Wong C, Thoma RS, Richman R, Wu Z, Piwnica-Worms H, Elledge SJ. Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25 Science. 277: 1497-1501. PMID 9278511 DOI: 10.1126/Science.277.5331.1497  0.705
1997 Sanchez Y, Zhou Z, Huang M, Kemp BE, Elledge SJ. Analysis of budding yeast kinases controlled by DNA damage Methods in Enzymology. 283: 398-410. PMID 9251037 DOI: 10.1016/S0076-6879(97)83033-9  0.816
1997 Dynlacht BD, Ngwu C, Winston J, Swindell EC, Elledge SJ, Harlow E, Harper JW. Purification and analysis of CIP/KIP proteins. Methods in Enzymology. 283: 230-44. PMID 9251023 DOI: 10.1016/S0076-6879(97)83019-4  0.329
1997 Aronheim A, Zandi E, Hennemann H, Elledge SJ, Karin M. Isolation of an AP-1 repressor by a novel method for detecting protein- protein interactions Molecular and Cellular Biology. 17: 3094-3102. PMID 9154808 DOI: 10.1128/Mcb.17.6.3094  0.343
1996 Elledge SJ, Winston J, Harper JW. A question of balance: the role of cyclin-kinase inhibitors in development and tumorigenesis. Trends in Cell Biology. 6: 388-392. PMID 15157521 DOI: 10.1016/0962-8924(96)10030-1  0.329
1996 Sicinski P, Donaher JL, Geng Y, Parker SB, Gardner H, Park MY, Robker RL, Richards JS, McGinnis LK, Biggers JD, Eppig JJ, Bronson RT, Elledge SJ, Weinberg RA. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature. 384: 470-4. PMID 8945475 DOI: 10.1038/384470A0  0.309
1996 Elledge SJ. Cell Cycle Checkpoints: Preventing an Identity Crisis Science. 274: 1664-1672. PMID 8939848 DOI: 10.1126/Science.274.5293.1664  0.438
1996 Navas TA, Sanchez Y, Elledge SJ. RAD9 and DNA polymerase epsilon form parallel sensory branches for transducing the DNA damage checkpoint signal in Saccharomyces cerevisiae. Genes & Development. 10: 2632-2643. PMID 8895664 DOI: 10.1101/Gad.10.20.2632  0.699
1996 Siede W, Allen JB, Elledge SJ, Friedberg EC. The Saccharomyces cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment Journal of Bacteriology. 178: 5841-5843. PMID 8824640 DOI: 10.1128/Jb.178.19.5841-5843.1996  0.346
1996 Bai C, Elledge SJ. Gene identification using the yeast two-hybrid system☆ Methods in Enzymology. 273: 141-156. PMID 8791622 DOI: 10.1016/S0076-6879(96)73029-X  0.353
1996 Harper JW, Elledge SJ. Cdk inhibitors in development and cancer Current Opinion in Genetics & Development. 6: 56-64. PMID 8791491 DOI: 10.1016/S0959-437X(96)90011-8  0.384
1996 Bai C, Sen P, Hofmann K, Ma L, Goebl M, Harper JW, Elledge SJ. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell. 86: 263-274. PMID 8706131 DOI: 10.1016/S0092-8674(00)80098-7  0.365
1996 Matsuoka S, Thompson JS, Edwards MC, Barletta JM, Grundy P, Kalikin LM, Harper JW, Elledge SJ, Feinberg AP. Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15 Proceedings of the National Academy of Sciences of the United States of America. 93: 3026-3030. PMID 8610162 DOI: 10.1073/Pnas.93.7.3026  0.343
1996 Sanchez Y, Desany BA, Jones WJ, Liu Q, Wang B, Elledge SJ. Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways Science. 271: 357-360. PMID 8553072 DOI: 10.1126/Science.271.5247.357  0.695
1995 Allen JB, Walberg MW, Edwards MC, Elledge SJ. Finding prospective partners in the library: the two-hybrid system and phage display find a match Trends in Biochemical Sciences. 20: 511-516. PMID 8571453 DOI: 10.1016/S0968-0004(00)89119-7  0.343
1995 Helps NR, Barker HM, Elledge SJ, Cohen PT. Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53. Febs Letters. 377: 295-300. PMID 8549741 DOI: 10.1016/0014-5793(95)01347-4  0.312
1995 Parker SB, Eichele G, Zhang P, Rawls A, Sands AT, Bradley A, Olson EN, Harper JW, Elledge SJ. p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science (New York, N.Y.). 267: 1024-7. PMID 7863329 DOI: 10.1126/Science.7863329  0.32
1995 Staudinger J, Zhou J, Burgess R, Elledge SJ, Olson EN. PICK1: A perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system Journal of Cell Biology. 128: 263-271. PMID 7844141 DOI: 10.1083/Jcb.128.3.263  0.38
1995 Ouspenski II, Mueller UW, Matynia A, Sazer S, Elledge SJ, Brinkley BR. Ran-binding protein-1 is an essential component of the Ran/RCC1 molecular switch system in budding yeast. The Journal of Biological Chemistry. 270: 1975-8. PMID 7836422 DOI: 10.1074/Jbc.270.5.1975  0.402
1995 Lee T, Elledge SJ, Butel JS. Hepatitis B virus X protein interacts with a probable cellular DNA repair protein. Journal of Virology. 69: 1107-1114. PMID 7815490 DOI: 10.1128/Jvi.69.2.1107-1114.1995  0.378
1995 Navas TA, Zhou Z, Elledge SJ. DNA polymerase ϵ links the DNA replication machinery to the S phase checkpoint Cell. 80: 29-39. PMID 7813016 DOI: 10.1016/0092-8674(95)90448-4  0.545
1995 Matsuoka S, Edwards MC, Bai C, Parker S, Zhang P, Baldini A, Harper JW, Elledge SJ. P57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene Genes and Development. 9: 650-662. PMID 7729684 DOI: 10.1101/Gad.9.6.650  0.367
1995 Deng C, Zhang P, Harper JW, Elledge SJ, Leder P. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell. 82: 675-84. PMID 7664346 DOI: 10.1016/0092-8674(95)90039-X  0.315
1995 Harper JW, Elledge SJ, Keyomarsi K, Dynlacht B, Tsai LH, Zhang P, Dobrowolski S, Bai C, Connell-Crowley L, Swindell E. Inhibition of cyclin-dependent kinases by p21. Molecular Biology of the Cell. 6: 387-400. PMID 7626805 DOI: 10.1091/Mbc.6.4.387  0.319
1995 Sanchez Y, Elledge SJ. Stopped for repairs Bioessays. 17: 545-548. PMID 7575496 DOI: 10.1002/Bies.950170611  0.692
1995 Tian Q, Taupin J-, Elledge S, Robertson M, Anderson P. Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. Journal of Experimental Medicine. 182: 865-874. PMID 7544399 DOI: 10.1084/Jem.182.3.865  0.344
1994 Li L, Elledge SJ, Peterson CA, Bales ES, Legerski RJ. Specific association between the human DNA repair proteins XPA and ERCC1. Proceedings of the National Academy of Sciences of the United States of America. 91: 5012-6. PMID 8197174 DOI: 10.1073/Pnas.91.11.5012  0.41
1994 Dulić V, Kaufmann WK, Wilson SJ, Tlsty TD, Lees E, Harper JW, Elledge SJ, Reed SI. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell. 76: 1013-23. PMID 8137420 DOI: 10.1016/0092-8674(94)90379-4  0.359
1994 Helps NR, Street AJ, Elledge SJ, Cohen PTW. Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli Febs Letters. 340: 93-98. PMID 8119416 DOI: 10.1016/0014-5793(94)80179-7  0.307
1994 Allen JB, Zhou Z, Siede W, Friedberg EC, Elledge SJ. The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast Genes and Development. 8: 2401-2415. PMID 7958905 DOI: 10.1101/Gad.8.20.2401  0.562
1994 Flores-Rozas H, Kelman Z, Dean FB, Pan ZQ, Harper JW, Elledge SJ, O'Donnell M, Hurwitz J. Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase δ holoenzyme Proceedings of the National Academy of Sciences of the United States of America. 91: 8655-8659. PMID 7915843 DOI: 10.1073/Pnas.91.18.8655  0.435
1994 Allen JB, Elledge SJ. A family of vectors that facilitate transposon and insertional mutagenesis of cloned genes in yeast. Yeast. 10: 1267-1272. PMID 7900415 DOI: 10.1002/Yea.320101003  0.31
1994 Durfee T, Mancini MA, Jones D, Elledge SJ, Lee W. The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing. Journal of Cell Biology. 127: 609-622. PMID 7525595 DOI: 10.1083/Jcb.127.3.609  0.343
1993 Durfee T, Becherer K, Chen P, Yeh S, Yang Y, Kilburn AE, Lee W, Elledge SJ. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes & Development. 7: 555-569. PMID 8384581 DOI: 10.1101/Gad.7.4.555  0.349
1993 Elledge SJ, Zhou Z, Allen JB, Navas TA. DNA damage and cell cycle regulation of ribonucleotide reductase. Bioessays. 15: 333-339. PMID 8343143 DOI: 10.1002/Bies.950150507  0.564
1993 Zhou Z, Elledge SJ. DUN1 encodes a protein kinase that controls the DNA damage response in yeast. Cell. 75: 1119-1127. PMID 8261511 DOI: 10.1016/0092-8674(93)90321-G  0.557
1993 Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases Cell. 75: 805-816. PMID 8242751 DOI: 10.1016/0092-8674(93)90499-G  0.357
1993 Elledge SJ, Bai C, Edwards MC. Cloning Mammalian Genes Using cDNA Expression Libraries in Saccharomyces cerevisiae Methods. 5: 96-101. DOI: 10.1006/Meth.1993.1013  0.334
1992 Ramer SW, Elledge SJ, Davis RW. Dominant genetics using a yeast genomic library under the control of a strong inducible promoter. Proceedings of the National Academy of Sciences of the United States of America. 89: 11589-93. PMID 1454852 DOI: 10.1073/Pnas.89.23.11589  0.537
1992 Elledge SJ, Zhou Z, Allen JB. Ribonucleotide reductase: regulation, regulation, regulation Trends in Biochemical Sciences. 17: 119-123. PMID 1412696 DOI: 10.1016/0968-0004(92)90249-9  0.534
1992 Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JM. Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science (New York, N.Y.). 257: 1689-94. PMID 1388288 DOI: 10.1126/Science.1388288  0.359
1992 Elledge SJ, Richman R, Hall FL, Williams RT, Lodgson N, Harper JW. CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle. Proceedings of the National Academy of Sciences of the United States of America. 89: 2907-11. PMID 1372993 DOI: 10.1073/Pnas.89.7.2907  0.388
1991 Elledge SJ, Mulligan JT, Ramer SW, Spottswood M, Davis RW. Lambda YES: a multifunctional cDNA expression vector for the isolation of genes by complementation of yeast and Escherichia coli mutations. Proceedings of the National Academy of Sciences of the United States of America. 88: 1731-5. PMID 1848010 DOI: 10.1073/Pnas.88.5.1731  0.479
1991 Elledge SJ, Spottswood MR. A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1. The Embo Journal. 10: 2653-2659. DOI: 10.1002/J.1460-2075.1991.Tb07808.X  0.369
1990 Elledge SJ, Davis RW. Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase. Genes & Development. 4: 740-51. PMID 2199320 DOI: 10.1101/Gad.4.5.740  0.564
1990 Jasin M, Elledge SJ, Davis RW, Berg P. Gene targeting at the human CD4 locus by epitope addition. Genes & Development. 4: 157-66. PMID 1692556 DOI: 10.1101/Gad.4.2.157  0.488
1989 Elledge SJ, Davis RW. Identification of the DNA damage-responsive element of RNR2 and evidence that four distinct cellular factors bind it. Molecular and Cellular Biology. 9: 5373-86. PMID 2685561 DOI: 10.1128/Mcb.9.12.5373  0.553
1989 Elledge SJ, Sugiono P, Guarente L, Davis RW. Genetic selection for genes encoding sequence-specific DNA-binding proteins. Proceedings of the National Academy of Sciences of the United States of America. 86: 3689-93. PMID 2657725 DOI: 10.1073/Pnas.86.10.3689  0.541
1989 Elledge SJ, Davis RW. Position and density effects on repression by stationary and mobile DNA-binding proteins. Genes & Development. 3: 185-97. PMID 2523839 DOI: 10.1101/Gad.3.2.185  0.526
1989 Elledge SJ, Davis RW. DNA damage induction of ribonucleotide reductase. Molecular and Cellular Biology. 9: 4932-40. PMID 2513480 DOI: 10.1128/Mcb.9.11.4932  0.558
1988 Elledge SJ, Davis RW. A family of versatile centromeric vectors designed for use in the sectoring-shuffle mutagenesis assay in Saccharomyces cerevisiae. Gene. 70: 303-12. PMID 3063604 DOI: 10.1016/0378-1119(88)90202-8  0.472
1987 Elledge SJ, Davis RW. Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability. Molecular and Cellular Biology. 7: 2783-93. PMID 3313004 DOI: 10.1128/Mcb.7.8.2783  0.559
1987 Snyder M, Elledge S, Sweetser D, Young RA, Davis RW. Lambda gt 11: gene isolation with antibody probes and other applications. Methods in Enzymology. 154: 107-28. PMID 2448583 DOI: 10.1016/0076-6879(87)54073-3  0.661
1986 Snyder M, Elledge S, Davis RW. Rapid mapping of antigenic coding regions and constructing insertion mutations in yeast genes by mini-Tn10 "transplason" mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. 83: 730-4. PMID 3003747 DOI: 10.1073/Pnas.83.3.730  0.564
1985 Perry KL, Elledge SJ, Mitchell BB, Marsh L, Walker GC. umuDC and mucAB operons whose products are required for UV light- and chemical-induced mutagenesis: UmuD, MucA, and LexA proteins share homology. Proceedings of the National Academy of Sciences of the United States of America. 82: 4331-5. PMID 2989816 DOI: 10.1073/Pnas.82.13.4331  0.502
1985 Elledge SJ, Walker GC. Phasmid vectors for identification of genes by complementation of Escherichia coli mutants. Journal of Bacteriology. 162: 777-83. PMID 2985547 DOI: 10.1128/Jb.162.2.777-783.1985  0.523
1985 Winans SC, Elledge SJ, Krueger JH, Walker GC. Site-directed insertion and deletion mutagenesis with cloned fragments in Escherichia coli. Journal of Bacteriology. 161: 1219-21. PMID 2982787 DOI: 10.1128/Jb.161.3.1219-1221.1985  0.692
1983 Elledge SJ, Walker GC. The muc genes of pKM101 are induced by DNA damage. Journal of Bacteriology. 155: 1306-15. PMID 6350267 DOI: 10.1128/Jb.155.3.1306-1315.1983  0.552
1983 Walker GC, Elledge SJ, Perry KL, Bagg A, Kenyon CJ. Regulation and function of cellular gene products involved in UV and chemical mutagenesis in E. coli. Basic Life Sciences. 23: 181-202. PMID 6340657 DOI: 10.1007/978-1-4684-4382-0_7  0.558
1983 Elledge SJ, Walker GC. Proteins required for ultraviolet light and chemical mutagenesis. Identification of the products of the umuC locus of Escherichia coli. Journal of Molecular Biology. 164: 175-92. PMID 6302271 DOI: 10.1016/0022-2836(83)90074-8  0.535
1983 Krueger JH, Elledge SJ, Walker GC. Isolation and characterization of Tn5 insertion mutations in the lexA gene of Escherichia coli. Journal of Bacteriology. 153: 1368-78. PMID 6298183 DOI: 10.1128/Jb.153.3.1368-1378.1983  0.521
1982 Walker GC, Elledge SJ, Kenyon CJ, Krueger JH, Perry KL. Mutagenesis and other responses induced by DNA damage in Escherichia coli. Biochimie. 64: 607-10. PMID 6291635 DOI: 10.1016/S0300-9084(82)80097-7  0.539
1982 Walker GC, Kenyon CJ, Bagg A, Elledge SJ, Perry KL, Shanabruch WG. Regulation and functions of Escherichia coli genes induced by DNA damage. Basic Life Sciences. 20: 43-63. PMID 6287997 DOI: 10.1007/978-1-4613-3476-7_2  0.555
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