| Year |
Citation |
Score |
| 2021 |
Sun Y, Wang J, Long T, Qi X, Donnelly L, Elghobashi-Meinhardt N, Esparza L, Cohen JC, Xie XS, Hobbs HH, Li X. Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34404721 DOI: 10.1073/pnas.2110483118 |
0.369 |
|
| 2020 |
Adam RC, Mintah IJ, Alexa-Braun CA, Shihanian LM, Lee JS, Banerjee P, Hamon SC, Kim HI, Cohen JC, Hobbs HH, Van Hout C, Gromada J, Murphy AJ, Yancopoulos GD, Sleeman MW, et al. Angiopoietin-like protein 3 (ANGPTL3) governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance. Journal of Lipid Research. PMID 32646941 DOI: 10.1194/jlr.RA120000888 |
0.339 |
|
| 2017 |
Chakrabarti RS, Ingham SA, Kozlitina J, Gay A, Cohen JC, Radhakrishnan A, Hobbs HH. Variability of cholesterol accessibility in human red blood cells measured using a bacterial cholesterol-binding toxin. Elife. 6. PMID 28169829 DOI: 10.7554/Elife.23355 |
0.536 |
|
| 2017 |
Lee J(, Rosenbaum D, Hobbs H. Structural Role of ABCG5/ABCG8 in Sterol Transport Biophysical Journal. 112: 22a. DOI: 10.1016/J.Bpj.2016.11.153 |
0.646 |
|
| 2016 |
Lee JY, Kinch LN, Borek DM, Wang J, Wang J, Urbatsch IL, Xie XS, Grishin NV, Cohen JC, Otwinowski Z, Hobbs HH, Rosenbaum DM. Crystal structure of the human sterol transporter ABCG5/ABCG8. Nature. PMID 27144356 DOI: 10.1038/Nature17666 |
0.647 |
|
| 2016 |
Smagris E, Gilyard S, BasuRay S, Cohen JC, Hobbs HH. Inactivation of Tm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but not Secretion of Very Low Density Lipoproteins. The Journal of Biological Chemistry. PMID 27013658 DOI: 10.1074/jbc.M116.719955 |
0.32 |
|
| 2012 |
Rios JJ, Shastry S, Jasso J, Hauser N, Garg A, Bensadoun A, Cohen JC, Hobbs HH. Deletion of GPIHBP1 causing severe chylomicronemia Journal of Inherited Metabolic Disease. 35: 531-540. PMID 22008945 DOI: 10.1007/S10545-011-9406-5 |
0.318 |
|
| 2011 |
Wang J, Grishin N, Kinch L, Cohen JC, Hobbs HH, Xie XS. Sequences in the nonconsensus nucleotide-binding domain of ABCG5/ABCG8 required for sterol transport. The Journal of Biological Chemistry. 286: 7308-14. PMID 21209088 DOI: 10.1074/Jbc.M110.210880 |
0.345 |
|
| 2010 |
Musunuru K, Pirruccello JP, Do R, Peloso GM, Guiducci C, Sougnez C, Garimella KV, Fisher S, Abreu J, Barry AJ, Fennell T, Banks E, Ambrogio L, Cibulskis K, Kernytsky A, ... ... Hobbs HH, et al. Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia. The New England Journal of Medicine. 363: 2220-7. PMID 20942659 DOI: 10.1056/Nejmoa1002926 |
0.397 |
|
| 2009 |
Romeo S, Yin W, Kozlitina J, Pennacchio LA, Boerwinkle E, Hobbs HH, Cohen JC. Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans. The Journal of Clinical Investigation. 119: 70-9. PMID 19075393 DOI: 10.1172/Jci37118 |
0.307 |
|
| 2009 |
Horton JD, Cohen JC, Hobbs HH. PCSK9: a convertase that coordinates LDL catabolism. Journal of Lipid Research. 50: S172-7. PMID 19020338 DOI: 10.1194/jlr.R800091-JLR200 |
0.361 |
|
| 2008 |
Zhang DW, Garuti R, Tang WJ, Cohen JC, Hobbs HH. Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor Proceedings of the National Academy of Sciences of the United States of America. 105: 13045-13050. PMID 18753623 DOI: 10.1073/pnas.0806312105 |
0.346 |
|
| 2008 |
Fahmi S, Yang C, Esmail S, Hobbs HH, Cohen JC. Functional characterization of genetic variants in NPC1L1 supports the sequencing extremes strategy to identify complex trait genes Human Molecular Genetics. 17: 2101-2107. PMID 18413323 DOI: 10.1093/hmg/ddn108 |
0.3 |
|
| 2007 |
Michaely P, Zhao Z, Li WP, Garuti R, Huang LJ, Hobbs HH, Cohen JC. Identification of a VLDL-induced, FDNPVY-independent internalization mechanism for the LDLR. The Embo Journal. 26: 3273-82. PMID 17581630 DOI: 10.1038/sj.emboj.7601769 |
0.321 |
|
| 2007 |
Zhang DW, Lagace TA, Garuti R, Zhao Z, McDonald M, Horton JD, Cohen JC, Hobbs HH. Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation. The Journal of Biological Chemistry. 282: 18602-12. PMID 17452316 DOI: 10.1074/Jbc.M702027200 |
0.386 |
|
| 2007 |
Horton JD, Cohen JC, Hobbs HH. Molecular biology of PCSK9: its role in LDL metabolism Trends in Biochemical Sciences. 32: 71-77. PMID 17215125 DOI: 10.1016/j.tibs.2006.12.008 |
0.358 |
|
| 2007 |
Jones C, Garuti R, Michaely P, Li WP, Maeda N, Cohen JC, Herz J, Hobbs HH. Disruption of LDL but not VLDL clearance in autosomal recessive hypercholesterolemia. The Journal of Clinical Investigation. 117: 165-74. PMID 17200716 DOI: 10.1172/Jci29415 |
0.523 |
|
| 2006 |
Zhao Z, Tuakli-Wosornu Y, Lagace TA, Kinch L, Grishin NV, Horton JD, Cohen JC, Hobbs HH. Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote American Journal of Human Genetics. 79: 514-523. PMID 16909389 DOI: 10.1086/507488 |
0.337 |
|
| 2006 |
Yang C, McDonald JG, Patel A, Zhang Y, Umetani M, Xu F, Westover EJ, Covey DF, Mangelsdorf DJ, Cohen JC, Hobbs HH. Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. The Journal of Biological Chemistry. 281: 27816-26. PMID 16857673 DOI: 10.1074/Jbc.M603781200 |
0.37 |
|
| 2006 |
Kotowski IK, Pertsemlidis A, Luke A, Cooper RS, Vega GL, Cohen JC, Hobbs HH. A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol. American Journal of Human Genetics. 78: 410-22. PMID 16465619 DOI: 10.1086/500615 |
0.305 |
|
| 2005 |
Garuti R, Jones C, Li WP, Michaely P, Herz J, Gerard RD, Cohen JC, Hobbs HH. The modular adaptor protein autosomal recessive hypercholesterolemia (ARH) promotes low density lipoprotein receptor clustering into clathrin-coated pits. The Journal of Biological Chemistry. 280: 40996-1004. PMID 16179341 DOI: 10.1074/Jbc.M509394200 |
0.547 |
|
| 2005 |
Cohen J, Pertsemlidis A, Kotowski IK, Graham R, Garcia CK, Hobbs HH. Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nature Genetics. 37: 161-5. PMID 15654334 DOI: 10.1038/ng1509 |
0.401 |
|
| 2005 |
Yu L, Gupta S, Xu F, Liverman AD, Moschetta A, Mangelsdorf DJ, Repa JJ, Hobbs HH, Cohen JC. Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion. The Journal of Biological Chemistry. 280: 8742-7. PMID 15611112 DOI: 10.1074/Jbc.M411080200 |
0.341 |
|
| 2004 |
Yang C, Yu L, Li W, Xu F, Cohen JC, Hobbs HH. Disruption of cholesterol homeostasis by plant sterols. The Journal of Clinical Investigation. 114: 813-22. PMID 15372105 DOI: 10.1172/Jci22186 |
0.318 |
|
| 2004 |
Michaely P, Li WP, Anderson RG, Cohen JC, Hobbs HH. The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits. The Journal of Biological Chemistry. 279: 34023-31. PMID 15166224 DOI: 10.1074/jbc.M405242200 |
0.37 |
|
| 2004 |
Yu L, von Bergmann K, Lutjohann D, Hobbs HH, Cohen JC. Selective sterol accumulation in ABCG5/ABCG8-deficient mice. Journal of Lipid Research. 45: 301-7. PMID 14657202 DOI: 10.1194/Jlr.M300377-Jlr200 |
0.32 |
|
| 2003 |
Rader DJ, Cohen J, Hobbs HH. Monogenic hypercholesterolemia: New insights in pathogenesis and treatment Journal of Clinical Investigation. 111: 1795-1803. PMID 12813012 DOI: 10.1172/Jci18925 |
0.38 |
|
| 2003 |
Jones C, Hammer RE, Li WP, Cohen JC, Hobbs HH, Herz J. Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia. The Journal of Biological Chemistry. 278: 29024-30. PMID 12746448 DOI: 10.1074/Jbc.M304855200 |
0.54 |
|
| 2003 |
Cohen JC, Kimmel M, Polanski A, Hobbs HH. Molecular mechanisms of autosomal recessive hypercholesterolemia. Current Opinion in Lipidology. 14: 121-7. PMID 12642779 DOI: 10.1097/00041433-200304000-00002 |
0.42 |
|
| 2003 |
Yu L, York J, von Bergmann K, Lutjohann D, Cohen JC, Hobbs HH. Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8. The Journal of Biological Chemistry. 278: 15565-70. PMID 12601003 DOI: 10.1074/Jbc.M301311200 |
0.393 |
|
| 2002 |
Yu L, Hammer RE, Li-Hawkins J, Von Bergmann K, Lutjohann D, Cohen JC, Hobbs HH. Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proceedings of the National Academy of Sciences of the United States of America. 99: 16237-42. PMID 12444248 DOI: 10.1073/Pnas.252582399 |
0.379 |
|
| 2002 |
Wilund KR, Yi M, Campagna F, Arca M, Zuliani G, Fellin R, Ho YK, Garcia JV, Hobbs HH, Cohen JC. Molecular mechanisms of autosomal recessive hypercholesterolemia. Human Molecular Genetics. 11: 3019-30. PMID 12417523 DOI: 10.1093/Hmg/11.24.3019 |
0.418 |
|
| 2002 |
He G, Gupta S, Yi M, Michaely P, Hobbs HH, Cohen JC. ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2. The Journal of Biological Chemistry. 277: 44044-9. PMID 12221107 DOI: 10.1074/jbc.M208539200 |
0.329 |
|
| 2002 |
Yu L, Li-Hawkins J, Hammer RE, Berge KE, Horton JD, Cohen JC, Hobbs HH. Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. The Journal of Clinical Investigation. 110: 671-80. PMID 12208868 DOI: 10.1172/Jci16001 |
0.344 |
|
| 2002 |
Repa JJ, Berge KE, Pomajzl C, Richardson JA, Hobbs H, Mangelsdorf DJ. Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. The Journal of Biological Chemistry. 277: 18793-800. PMID 11901146 DOI: 10.1074/JBC.M109927200 |
0.371 |
|
| 2001 |
Hubacek JA, Berge KE, Cohen JC, Hobbs HH. Mutations in ATP-cassette binding proteins G5 (ABCG5) and G8 (ABCG8) causing sitosterolemia Human Mutation. 18: 359-360. PMID 11668628 DOI: 10.1002/HUMU.1206 |
0.308 |
|
| 2001 |
Garcia CK, Wilund K, Arca M, Zuliani G, Fellin R, Maioli M, Calandra S, Bertolini S, Cossu F, Grishin N, Barnes R, Cohen JC, Hobbs HH. Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein. Science (New York, N.Y.). 292: 1394-8. PMID 11326085 DOI: 10.1126/Science.1060458 |
0.466 |
|
| 2000 |
Berge KE, Tian H, Graf GA, Yu L, Grishin NV, Schultz J, Kwiterovich P, Shan B, Barnes R, Hobbs HH. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters Science. 290: 1771-1775. PMID 11099417 DOI: 10.1126/Science.290.5497.1771 |
0.447 |
|
| 1999 |
Stangl H, Hyatt M, Hobbs HH. Transport of lipids from high and low density lipoproteins via scavenger receptor-BI. The Journal of Biological Chemistry. 274: 32692-8. PMID 10551825 DOI: 10.1074/jbc.274.46.32692 |
0.372 |
|
| 1998 |
Stangl H, Cao G, Wyne KL, Hobbs HH. Scavenger receptor, class B, type I-dependent stimulation of cholesterol esterification by high density lipoproteins, low density lipoproteins, and nonlipoprotein cholesterol. The Journal of Biological Chemistry. 273: 31002-8. PMID 9812997 DOI: 10.1074/jbc.273.47.31002 |
0.363 |
|
| 1997 |
Cao G, Garcia CK, Wyne KL, Schultz RA, Parker KL, Hobbs HH. Structure and localization of the human gene encoding SR-BI/CLA-1. Evidence for transcriptional control by steroidogenic factor 1. The Journal of Biological Chemistry. 272: 33068-76. PMID 9407090 DOI: 10.1074/jbc.272.52.33068 |
0.331 |
|
| 1996 |
Cohen J, Gaw A, Barnes RI, Landschulz KT, Hobbs HH. Genetic factors that contribute to interindividual variations in plasma low density lipoprotein-cholesterol levels. Ciba Foundation Symposium. 197: 194-206; discussion . PMID 8827375 DOI: 10.1002/9780470514887.CH11 |
0.332 |
|
| 1996 |
Acton S, Rigotti A, Landschulz KT, Xu S, Hobbs HH, Krieger M. Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science (New York, N.Y.). 271: 518-20. PMID 8560269 DOI: 10.1126/science.271.5248.518 |
0.573 |
|
| 1995 |
Hua X, Wu J, Goldstein JL, Brown MS, Hobbs HH. Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13. Genomics. 25: 667-73. PMID 7759101 DOI: 10.1016/0888-7543(95)80009-B |
0.54 |
|
| 1993 |
Hobbs HH, Brown MS, Goldstein JL. Molecular genetics of the LDL receptor gene in familial hypercholesterolemia. Human Mutation. 1: 445-66. PMID 1301956 DOI: 10.1002/HUMU.1380010602 |
0.635 |
|
| 1991 |
Hobbs HH, Russell DW, Brown MS, Goldstein JL. The LDL receptor locus in familial hypercholesterolemia: mutational analysis of a membrane protein. Annual Review of Genetics. 24: 133-70. PMID 2088165 DOI: 10.1146/Annurev.Ge.24.120190.001025 |
0.575 |
|
| 1991 |
Vega GL, Hobbs HH, Grundy SM. Low density lipoprotein kinetics in a family having defective low density lipoprotein receptors in which hypercholesterolemia is suppressed. Arteriosclerosis and Thrombosis : a Journal of Vascular Biology. 11: 578-85. PMID 2029498 DOI: 10.1161/01.ATV.11.3.578 |
0.366 |
|
| 1990 |
Leitersdorf E, Tobin EJ, Davignon J, Hobbs HH. Common low-density lipoprotein receptor mutations in the French Canadian population Journal of Clinical Investigation. 85: 1014-1023. PMID 2318961 DOI: 10.1172/JCI114531 |
0.369 |
|
| 1989 |
Hobbs HH, Leitersdorf E, Leffert CC, Cryer DR, Brown MS, Goldstein JL. Evidence for a dominant gene that suppresses hypercholesterolemia in a family with defective low density lipoprotein receptors. The Journal of Clinical Investigation. 84: 656-64. PMID 2760205 DOI: 10.1172/JCI114212 |
0.644 |
|
| 1989 |
Leitersdorf E, Van Der Westhuyzen DR, Coetzee GA, Hobbs HH. Two common low density lipoprotein receptor gene mutations cause familial hypercholesterolemia in Afrikaners Journal of Clinical Investigation. 84: 954-961. PMID 2569482 |
0.387 |
|
| 1988 |
Hobbs HH, Leitersdorf E, Goldstein JL, Brown MS, Russell DW. Multiple crm- mutations in familial hypercholesterolemia. Evidence for 13 alleles, including four deletions. The Journal of Clinical Investigation. 81: 909-17. PMID 3343347 DOI: 10.1172/Jci113402 |
0.541 |
|
| 1988 |
Leitersdorf E, Hobbs HH, Fourie AM, Jacobs M, Van der Westhuyzen DR, Coetzee GA. Deletion in the first cysteine-rich repeat of low density lipoprotein receptor impairs its transport but not lipoprotein binding in fibroblasts from a subject with familial hypercholesterolemia Proceedings of the National Academy of Sciences of the United States of America. 85: 7912-7916. PMID 3263645 |
0.409 |
|
| 1987 |
Hobbs HH, Brown MS, Russell DW, Davignon J, Goldstein JL. Deletion in the gene for the low-density-lipoprotein receptor in a majority of French Canadians with familial hypercholesterolemia. The New England Journal of Medicine. 317: 734-7. PMID 3627182 DOI: 10.1056/Nejm198709173171204 |
0.587 |
|
| 1986 |
Russell DW, Lehrman MA, Südhof TC, Yamamoto T, Davis CG, Hobbs HH, Brown MS, Goldstein JL. The LDL receptor in familial hypercholesterolemia: use of human mutations to dissect a membrane protein. Cold Spring Harbor Symposia On Quantitative Biology. 51: 811-9. PMID 3472763 DOI: 10.1101/Sqb.1986.051.01.094 |
0.671 |
|
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